Adenium Biotech. Management: - Peter Nordkild, MD, CEO, ex Novo Nordisk, Ferring, Egalet - Søren Neve, PhD, project director, ex Lundbeck, Novozymes
|
|
- Blake Boone
- 5 years ago
- Views:
Transcription
1
2 Adenium Biotech Management: - Peter Nordkild, MD, CEO, ex Novo Nordisk, Ferring, Egalet - Søren Neve, PhD, project director, ex Lundbeck, Novozymes Board of Directors: - Stephan Christgau, PhD, chairman, Novo A/S - Anker Lundemose, MD, ex Novo Nordisk, ex OSI Pharmaceuticals - Khalid Islam, PhD, ex Arpida - Ejner Bech Jensen, MSc, VP R&D Novozymes A/S Current Investor: - Novo A/S
3 Bad Bugs need new drugs The total US market of hospital acquired infections was in 2006 estimated at USD 7.9 billion. 65% of hospital acquired infections are caused by Gram-negative bacteria (Clin Infect Dis 2005;41: ) Resistance
4 Resistance is inevitable and requires novel antibiotics Antibiotic Year deployed Resistance observed Sulfonamides 1930s 1940s Penicillin Streptomycin Chloramphenicol Tetracycline Erythromycin Vancomycin Methicillin Ampicillin Cephalosporins 1960s Late 1960s
5 Key antibacterial needs 2011 Source: Datamonitor 02/2011.
6 Arenicin A new Gram-negative antibiotic
7 Arenicin program highlights Spin out from Novozymes AMP group Novel mode of action, no cross resistance to existing antibiotics Bactericidal on broad range of multidrug resistant Gram-negative bacteria Development plan includes orphan drug opportunity Few competing bactericidal products in development Strong lead/back up product candidates Stable IV formulations Strong IP ( ) Addresses significant unmet Gram-negative clinical need Large, growing and non-generic hospital market of USD 8 billion Hospital and primarily ICU based specialist target group requiring small sales force
8 Healthcare associated infections in the US 2010 Source: Datamonitor 02/2011
9 Nosocomial indications - volume/value Source : Datamonitor 03/2007
10 ESKAPE Pathogens Enterococcus faecium Staphylococcus aureus Klebsiella species Acinetobacter baumannii Pseudomonas aeruginosa Enterobacter E.coli E. aerogenes E. cloacae
11 Generation of new variants
12 Arenicin-3 NZ17000 Isolated from lugworm (Arenicola marina) 21 amino acids Very stable beta-hairpin structure MW kda pi ~ 11.27
13 Variant generation through consecutive screening of yeast libraries variants Evaluation of variants Output 1. screen S. cerevisiae ( ) - plate screen vs. E. coli in the presence of 5% blood - retest vs. other Gram- bacteria 2. screen purified peptide (250) - MICs vs. 11 bacteria +/- serum - killing kinetic - protein binding 3. screen chemical synthesis (10) - a range of in vitro & in vivo parameters - MTD, peritonitis, cystitis etc NZ17143 and NZ17211 with distinct features Improved protein binding properties Improved toxicological properties 2 new Arenicin variants
14 Antimicrobial spectrum and protein binding of NZ17000, NZ17143 and NZ17211 Arenicin variant E. coli (μg/ml) K. pneumoniae (μg/ml) E. cloacae (μg/ml) P. aeruginosa (μg/ml) S. maltophilia (μg/ml) A. baumanii (μg/ml) M. catarrhalis (μg/ml) NZ NZ NZ Protein Binding
15 Antimicrobial activity against selected resistant Gram-negative strains Bacteria No NZ17000 NZ17143 NZ17211 Carbapenem resistant Klebsiella pneumoniae (KPC2) Carbapenem resistant Pseudomonas aeruginosa Carbapenem resistant Klebsiella pneumoniae (NDM-1) MIC (µg/ml) MIC (µg/ml) MIC (µg/ml) Tigecycline resistant Salmonella Hadar
16 MoA - localization of Arenicin 15 min 30 min 45 min Control Fosfomycin Polymycin B Arenicin-3 A. E. coli exposed for 30 min to NZ17000 and stained with TRITC. Treatment with NZ17000 results in influx of TRITC into the E. coli B. E. coli exposed for 30 min with TRITC labelled NZ Clusters of NZ17000 were localized in the bacterial membrane At OD600 =0.4 E.coli cells were exposed to 32ug/ml Arenicin, 64ug/ml Fosfomycin and 16ug/ml Polymycin B. Even at very high concentration of Arenicin-3, no dramatic morphological changes of the cells were observed.
17 Fold change MoA - ATP efflux after treatment with Arenicin Extracellular ATP after 10 min 25 Arenicin: Ar col pip Perturbs the membrane potential increasing the permeability of the bacterial membrane x MIC Inhibits the protein synthesis Arenicin-3 (Ar), colistin (col), and piperacillin (pip) induced release of ATP from E. coli. Exponential cells were incubated with drug for 10 minutes and ATP measured. y-axis is fold change relative to untreated (0xmic) and x-axis is fold MIC applied.
18 CFU/ml CFU/ ml of Pseudomonas Time kill of NZ17000 vs E.coli and Pseudomonas Time kill kinetics for Escherichia coli ATCC25922 NZ17000 in ca-müller Hinton broth Time (minutes) Growth control 10 x MIC Arenicin-3 (5µg/ml) 10 x MIC Gentamicin (5µg/ml) NZ17000 Time killing kinetics for Pseudomonas aeruginosa ATCC Time (minutes) Growth Control 0.25 x MIC NZ17000 ( 0.125µg/ml) 2 x MIC NZ17000 (1µg/ml) 10 x MIC NZ17000 (5µg/ml)
19 Dose response of NZ17000 in the UTI mouse model ED 50 ~1.5 mg/kg in urine and ~ 1.8 mg/kg in the bladder
20 Dose response of NZ17143 in the UTI mouse model ED 50 < 0.8 mg/kg in urine, bladder and in the kidneys
21 Dose response of NZ17211 in the UTI mouse model ED 50 < 0.8 mg/kg in urine, bladder and in the kidneys
22 NZ17143 NZ17211 NZ17000 Dose response in neutropenic mouse peritonitis model against a multi-resistant E. coli at 5 hours after treatment Blood Peritoneal fluid
23 Log 10 CFU/ml Log 10 CFU/ml Log 10 CFU/ml Efficacy of NZ17143/NZ17211 against multi-resistant E. coli in the murine Urinary Tract Infection model (UTI) 8 7 Urine 2 day post infection Urine day 2 post infection 8 7 Bladder 3 days post infection Bladder day 3 post infection 4 Kidney 3 days post infection Kidneys day 3 post infection vehicle NZ mg/kg NZ mg/kg Meropenem 40 mg/kg vehicle NZ mg/kg NZ mg/kg Meropenem 40 mg/kg vehicle NZ mg/kg NZ mg/kg Meropenem 40 mg/kg
24 Pharmacokinetic properties after IV administration Arenicin-3 variant Protein binding (%) T ½ (min) AUC (min*ug/ml) C max (ug/ml) Bioavailability (%, SC vs IV) NZ17000 > NZ NZ
25 Toxicological overview of NZ17000, NZ17143 and NZ17211 Variant NZ17000 (mg/kg) NZ17143 (mg/kg) NZ17211 (mg/kg) MTD (IV) NOAEL (IV) 7,
26 Arenicin summary New mode of action Spontaneous mutational frequency for E. coli is 3X10-9 and P. aeruginosa >10-8 Potent in vitro activity against a wide spectrum of Gramnegative bacteria Rapidly bactericidal MBCs ~ MICs No cross resistance to known antibiotics No or little inoculum effect Favorable efficacy in experimental animal models of infection Septicemia against E. coli and P. aeruginosa UTI against E. coli Thigh infections against E. coli.
Received 30 March 2005; returned 16 June 2005; revised 8 September 2005; accepted 12 September 2005
Journal of Antimicrobial Chemotherapy (2005) 56, 1047 1052 doi:10.1093/jac/dki362 Advance Access publication 20 October 2005 Evaluation of PPI-0903M (T91825), a novel cephalosporin: bactericidal activity,
More informationAffinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and ACCEPTED
AAC Accepts, published online ahead of print on February 00 Antimicrob. Agents Chemother. doi:./aac.01-0 Copyright 00, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights
More informationTP Larry Tsai, MD Chief Medical Officer Tetraphase Pharmaceuticals
TP-676 Larry Tsai, MD Chief Medical Officer Tetraphase Pharmaceuticals Tetraphase Pharmaceuticals Overview Tetraphase is developing novel antibiotics for serious and life-threatening Gram-negative MDR
More informationINNOVATION FOR UNMET MEDICAL NEEDS
INNOVATION FOR UNMET MEDICAL NEEDS About Qurient Co. Ltd. Founded in 2008 Headquarter in Seongnam, Gyeonggi-do, Korea Listed on KOSDAQ market with ticker: 115180 Network R&D company: Virtual R&D with a
More informationSep Oct Nov Dec Total
LB PAGE 2 LB PAGE 3 Sep Oct Nov Dec 2007 2007 2007 2007 Total Repeat Information Total Repeats 35 15 17 9 76 Repeat Rate 6.01% 0.17% 1.12% 0.39% 2.07% Repeat Chemistry 25 0 2 0 27 Repeat Extraction 1 0
More informationLaboratory CLSI M100-S18 update. Paul D. Fey, Ph.D. Associate Professor/Associate Director Josh Rowland, M.T. (ASCP) State Training Coordinator
Nebraska Public Health Laboratory 2008 CLSI M100-S18 update Paul D. Fey, Ph.D. Associate Professor/Associate Director Josh Rowland, M.T. (ASCP) State Training Coordinator Agenda Discuss 2008 M100- S18
More informationAntibiotic Resistance Pattern of Blood and CSF Culture Isolates At NHLS Academic Laboratories (2005)
Antibiotic Resistance Pattern of Blood and CSF Culture Isolates At NHLS Academic Laboratories (2005) Streptococcus pneumoniae (SP) Blood Culture Isolates Penicillin intermediate Penicillin Cefotaxime 336
More informationEvaluation of Antibacterial Effect of Odor Eliminating Compounds
Evaluation of Antibacterial Effect of Odor Eliminating Compounds Yuan Zeng, Bingyu Li, Anwar Kalalah, Sang-Jin Suh, and S.S. Ditchkoff Summary Antibiotic activity of ten commercially available odor eliminating
More informationCefotaxime Rationale for the EUCAST clinical breakpoints, version th September 2010
Cefotaxime Rationale for the EUCAST clinical breakpoints, version 1.0 26 th September 2010 Foreword EUCAST The European Committee on Antimicrobial Susceptibility Testing (EUCAST) is organised by the European
More informationCHAPTER 8 ANTIBACTERIAL ACTIVITY OF THE CRUDE ETHANOLIC EXTRACT AND THE ISOLATED COMPOUNDS FROM THE STEM OF COSTUS IGNEUS
CHAPTER 8 ANTIBACTERIAL ACTIVITY OF THE CRUDE ETHANOLIC EXTRACT AND THE ISOLATED COMPOUNDS FROM THE STEM OF COSTUS IGNEUS 8.1 INTRODUCTION Medicinal plants are the backbone of traditional medicine and
More informationThe CLSI Approach to Setting Breakpoints
The CLSI Approach to Setting Breakpoints Jean B. Patel, PhD, D(ABMM) Deputy Director, Office of Antimicrobial Resistance Division of Healthcare Quality Promotion National Center for Emerging and Zoonotic
More informationOther β-lactam. A. Carbapenems:
A. Carbapenems: Other β-lactam Carbapenems are synthetic β-lactam antibiotics Differ in structure from the penicillins in that the sulfur atom of the thiazolidine ring. Imipenem, meropenem, doripenem,
More informationDetermination of MIC & MBC
1 Determination of MIC & MBC Minimum inhibitory concentrations (MICs) are defined as the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight
More informationTranslocation Studies Mid-Term Review (MTR) Meeting Marseille, France
Marie Curie Actions Research Training Networks (RTN) Translocation Studies Mid-Term Review (MTR) Meeting Marseille, France F. Vidal-Aroca, M.G.P. Page and J. Dreier Background Deteriorating situation regarding
More informationHealthcare-associated infections acquired in intensive care units
SURVEILLANCE REPORT Annual Epidemiological Report for 2015 Healthcare-associated infections acquired in intensive care units Key facts In 2015, 11 788 (8.3%) of patients staying in an intensive care unit
More informationBelow is an overview of the oral and poster presentations featuring cefiderocol and S at IDWeek 2017:
SHIONOGI TO HIGHLIGHT RESEARCH ON CEFIDEROCOL (S-649266), A SIDEROPHORE CEPHALOSPORIN, AND S-033188, A CAP-DEPENDENT ENDONUCLEASE INHIBITOR FOR TREATMENT OF INFLUENZA, AT IDWEEK 2017 OSAKA, Japan and FLORHAM
More informationALERT. Clinical microbiology considerations related to the emergence of. New Delhi metallo beta lactamases (NDM 1) and Klebsiella
ALERT Clinical microbiology considerations related to the emergence of New Delhi metallo beta lactamases (NDM 1) and Klebsiella pneumoniae carbapenemases (KPC) amongst hospitalized patients in South Africa
More informationUniversity of Alberta Hospital Antibiogram for 2007 and 2008 Division of Medical Microbiology Department of Laboratory Medicine and Pathology
University of Alberta Hospital Antibiogram for 2007 and 2008 Division of Medical Microbiology Department of Laboratory Medicine and Pathology This material is supported in part by unrestricted educational
More informationAntibiotics to treat multi-drug-resistant bacterial infections
Antibiotics to treat multi-drug-resistant bacterial infections July 2013 JUNE 2013 Copyright 2013 Tetraphase Pharmaceuticals, Inc. 1 Forward Looking Statements and Other Important Cautions Any statements
More informationSuccessful treatment of pan - resistant pseudomonas Aerugınosa menıngıtıs wıth ıntrathecal polymyxın b therapy
ISPUB.COM The Internet Journal of Infectious Diseases Volume 7 Number 2 Successful treatment of pan - resistant pseudomonas Aerugınosa menıngıtıs wıth ıntrathecal polymyxın b F Simsek, T Yildirmak, G Cetmeli,
More informationExpert rules. for Gram-negatives
Academic Perspective in Expert rules Emerging Issues of Resistance in Gram-ve Bacteria for Gram-negatives Trevor Winstanley Sheffield Teaching Hospitals Presented on behalf of David Livermore University
More informationShirin Abadi, B.Sc.(Pharm.), ACPR, Pharm.D. Clinical Pharmacy Specialist & Pharmacy Education Coordinator, BC Cancer Agency Clinical Associate
Shirin Abadi, B.Sc.(Pharm.), ACPR, Pharm.D. Clinical Pharmacy Specialist & Pharmacy Education Coordinator, BC Cancer Agency Clinical Associate Professor of Pharmacy & Associate Member of Medicine, UBC
More informationAXITAB-CV TAB. COMPOSITION :
AXITAB-CV TAB. COMPOSITION : Each film coated tablet contains: Cefuroxime Axetil I.P. Eq. to Anhydrous 500mg. Potassium Clavulanate Diluted I.P. Eq. to Clavulanic Acid 125mg DESCRIPTION : Cefuroxime Axetil
More information(multidrug-resistant Pseudomonas aeruginosa; MDRP)
220 2009 (multidrug-resistant Pseudomonas aeruginosa; MDRP) 21 4 1 21 10 4 amikacin (AMK), imipenem/cilastatin (IPM), ciprofloxacin (CPFX) multidrug-resistant Pseudomonas aeruginosa (MDRP) CHROMagar TM
More informationEfficacy of Ceftaroline Fosamil against Escherichia coli and Klebsiella pneumoniae Strains in a rabbit meningitis model.
AAC Accepts, published online ahead of print on 3 September 2013 Antimicrob. Agents Chemother. doi:10.1128/aac.00285-13 Copyright 2013, American Society for Microbiology. All Rights Reserved. 1 1 2 Efficacy
More informationOptimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria
Infect Dis Ther (2015) 4:391 415 DOI 10.1007/s40121-015-0093-7 REVIEW Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria Phillip J. Bergen Zackery P. Bulman Cornelia B. Landersdorfer
More informationCefuroxime iv Rationale for the EUCAST clinical breakpoints, version th September 2010
Cefuroxime iv Rationale for the EUCAST clinical breakpoints, version 1.0 26 th September 2010 Foreword EUCAST The European Committee on Antimicrobial Susceptibility Testing (EUCAST) is organised by the
More informationby author ESCMID Online Lecture Library
The Karyatides at the Erechtheion Temple Devoted to the Women in the Audience At the top of the Museum the Karyatides, watching you through the years to come FOSFOMYCIN IN THE TREATMENT OF INFECTIONS
More informationDevelopment of C sporins. Beta-lactam antibiotics - Cephalosporins. Second generation C sporins. Targets - PBP s
Beta-lactam antibiotics - Cephalosporins Development of C sporins Targets - PBP s Activity - Cidal - growing organisms (like the penicillins) Principles of action - Affinity for PBP s Permeability properties
More informationNo Need to Agonize! Tips for the Diagnosis and Treatment of Complicated UTIs
ASCENSION TEXAS No Need to Agonize! Tips for the Diagnosis and Treatment of Complicated UTIs Austin Area Society of Health-System Pharmacists April 26, 2018 Amy Carr, PharmD PGY-2 Infectious Diseases Pharmacy
More informationIn Vitro Susceptibility Pattern of Cephalosporin- Resistant Gram-Negative Bacteria
In Vitro Susceptibility Pattern of Cephalosporin- Resistant Gram-Negative Bacteria Warunee Punpanich MD*, Worraporn Tantichattanon MD**, Siriporn Wongwatcharapaiboon MD**, Vipa Treeratweeraphong BSc, MSc***
More informationChapter 4. Anti-bacterial studies of PUFA extracts from Sardinella longiceps and Sardinella fimbriata. 4.1 Introduction
Anti-bacterial studies of PUFA extracts from Sardinella longiceps and Sardinella fimbriata C o n t e n t s 4.1 Introduction 4.2 Materials and Methods 4.2.1 Extract Preparation and Determination of PUFA
More informationTopical antimicrobial agents in wound care. Professor Val Edwards-Jones Manchester Metropolitan University UK
Topical antimicrobial agents in wound care Professor Val Edwards-Jones Manchester Metropolitan University UK Antimicrobial agents Antibacterial agents Antifungal agents Antiviral agents Antiparasitic agents?others
More informationPREVENTIVE MEDICINE - LABORATORY
Rev. Med. Chir. Soc. Med. Nat., Iaşi 2014 vol. 118, no. 3 PREVENTIVE MEDICINE - LABORATORY ORIGINAL PAPERS CLINICAL EPIDEMIOLOGICAL STUDY ON THE INCIDENCE OF ESCHERICHIA COLI INFECTIONS IN THE CANCER PATIENTS
More informationTreatment of febrile neutropenia in patients with neoplasia
Treatment of febrile neutropenia in patients with neoplasia George Samonis MD, PhD Medical Oncologist Infectious Diseases Specialist Professor of Medicine The University of Crete, Heraklion,, Crete, Greece
More informationReport on the Japanese Veterinary Antimicrobial Resistance Monitoring System
Report on the Japanese Veterinary Antimicrobial Resistance Monitoring System 2014 2015 National Veterinary Assay Laboratory Ministry of Agriculture, Forestry and Fisheries 2018 Contents Introduction...
More informationAgainst Aerobic Gram-Negative Bacilli
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Dec. 1979, p. 6-6 0066-0/79/1-06/05$0.00/0 Vol., No. 6 In Vitro Activity of LY17935, a New 1-Oxa Cephalosporin, Against Aerobic Gram-Negative Bacilli DENNIS G. DELGADO,
More informationImmunobiotics: Cloudbreak Antibody Drug Conjugates (ADC) Les Tari, PhD VP Discovery
Immunobiotics: Cloudbreak Antibody Drug Conjugates (ADC) Les Tari, PhD VP Discovery Cidara s pipeline addresses multiple unmet needs Program Indication Discovery IND- enable Ph 1 Ph 2 Ph 3 REZAFUNGIN IV
More informationNDA Briefing Document Anti-Infective Drugs Advisory Committee 05 December 2014
CEFTAZIDIME-AVIBACTAM FOR INJECTION for Treatment of Complicated Intra-abdominal Infection (used in combination with metronidazole), Complicated Urinary Tract Infection including Acute Pyelonephritis,
More informationSt. Joseph's Journal of Humanities and Science ISSN:
M. Parimala Celia et al. / St. Joseph s Journal of Humanities and Science (Volume 4 Issue 1 January 2017) 23-28 33 St. Joseph s Journal of Humanities and Science (Volume 4 Issue 2 August 2015) 33-38 St.
More informationNewark, NJ
Award Number: W81XWH-12-2-0076 TITLE: Evaluation of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad-Spectrum Antimicrobial for Drug- Resistant Wound Infections PRINCIPAL INVESTIGATOR: David
More informationKENNEL KARE SC DISINFECTANT / CLEANER / DEODORIZER Efficacy Data EPA Reg. #
Inc. Efficacy: Hospital Disinfection (at ½ ounce per gallon) Kennel Kare SC is bactericidal according to the AOAC Use Dilution Test method on hard inanimate surfaces modified in the presence of 5% organic
More informationTWIN POWER #17 #4017
Test Method: AOAC Use Dilution TWIN POWER #17 DISINFECTION DATA: Test Conditions: 2 oz/gal dilution, 5% organic soil load, 10 minute contact time, stainless steel carrier substrates, 20 C exposure temperature
More informationPlazomicin for complicated urinary tract infection
October 2016 Horizon Scanning Research & Intelligence Centre Plazomicin for complicated urinary tract infection NIHR HSRIC ID: 9787 Lay summary Serious infections caused by Gram-negative bacteria are becoming
More informationKENNEL KARE SC DISINFECTANT / CLEANER / DEODORIZER Efficacy Data EPA Reg. #
Inc. Efficacy: Disinfection (at ½ ounce per gallon) Kennel Kare SC is bactericidal according to the AOAC Use Dilution Test method on hard inanimate surfaces modified in the presence of 5% organic serum
More informationURINARY TRACT INFECTIONS 3 rd Y Med Students. Prof. Dr. Asem Shehabi Faculty of Medicine, University of Jordan
URINARY TRACT INFECTIONS 3 rd Y Med Students Prof. Dr. Asem Shehabi Faculty of Medicine, University of Jordan Urinary Tract Infections-1 Normal urine is sterile.. It contains fluids, salts, and waste products,
More information320 MBIO Microbial Diagnosis. Aljawharah F. Alabbad Noorah A. Alkubaisi 2017
320 MBIO Microbial Diagnosis Aljawharah F. Alabbad Noorah A. Alkubaisi 2017 Pathogens of the Urinary tract The urinary system is composed of organs that regulate the chemical composition and volume of
More informationProposals for E.coli surveillance Informatics- proposal for the Infection. VRE molecular epidemiology AMR alerts HPA repatriation Rotavirus
HPS Update Proposals for E.coli surveillance Informatics- proposal for the Infection Intelligence Platform (IIP) VRE molecular epidemiology AMR alerts HPA repatriation Rotavirus IIP Strategic intent.to
More informationRoula M. Abdel-Massih Dept. of Biology, University of Balamand, Lebanon
http://skinnywithfiber.org Roula M. Abdel-Massih Dept. of Biology, University of Balamand, Lebanon Ilex paraguariensis Classification and characteristics Family Aquifoliaceae Found mainly in South America
More informationSupporting Information
Supporting Information Discovery of linear low-cationic peptides to target methicillin-resistant Staphylococcus aureus in vivo Yuan Liu, Meirong Song, Shuangyang Ding,, Kui Zhu*,,, Beijing Advanced Innovation
More informationFrequency of Occurrence and Antimicrobial Susceptibility of Bacteria from ICU Patients with Pneumonia
Frequency of Occurrence and Antimicrobial Susceptibility of Bacteria from ICU Patients with Pneumonia Helio S. Sader, M.D.* Mariana Castanheira, Ph.D. Rodrigo E. Mendes, Ph.D. Robert K. Flamm, Ph.D. JMI
More informationlife-threatening infections
Vancomycin Vancomycin has become increasingly important in the treatment of life-threatening infections. MRSA infections. Methicillin-resistant Staphylococcus epidermidis (MRSE) infections Enterococcal
More informationMHSAL Guidelines for the Prevention and Control of Antimicrobial Resistant Organisms (AROs) - Response to Questions
MHSAL Guidelines for the Prevention and Control of Antimicrobial Resistant Organisms (AROs) - Response to Questions Dr. Andrew Walkty Medical Microbiologist, Diagnostic Services Manitoba (DSM) June. 17,
More informationCAVIWIPES1. Technical Bulletin
CAVIWIPES1 Technical Bulletin CaviWipes1 Disinfecting Towelettes are non-woven disposable towelettes pre-saturated with CaviCide1. CaviWipes 1 are intended for use in health care settings such as hospitals,
More informationQuestions and Answers about
Questions and Answers about What is PRO TEX TM Alcohol-Free, Foam Hand & Skin Sanitizer? PRO TEX TM Alcohol-Free, Foam Hand & Skin Sanitizer, based on the active ingredient Benzalkonium chloride, is a
More informationMacrolides, Clindamycin & Ketolides Polymyxins
Macrolides, Clindamycin & Ketolides Polymyxins Kwan Soo Ko Macrolides - Erythromycin - Azithromycin - Clarithromycin Lincosamides - Lincomycin - Clindamycin Unrelated chemically But, many similar biological
More informationPublic Health Surveillance for Multi Drug Resistant Organisms in Orange County
Public Health Surveillance for Multi Drug Resistant Organisms in Orange County Matt Zahn, MD Medical Director Epidemiology and Assessment Orange County Public Health Antimicrobial Mechanisms of Action
More informationA Snapshot of Colistin Use in South-East Europe and Particularly in Greece
A Snapshot of Colistin Use in South-East Europe and Particularly in Greece Helen Giamarellou 02.05.2013 When Greek Physicians Prescribe Colistin? It is mainly prescribed in the ICU for VAP, bacteremia
More informationEfficacy Data. Disinfectant Cleaner & Odor Counteractant EPA REG. #
SENTS-ALE Hospital Disinfection (at 2 ounces per gallon)) Scents-Able is bactericidal according to the AOA Use Dilution Test method on hard inanimate surfaces modified in the presence of 5% organic serum
More informationDiscussion points CLSI M100 S19 Update. #1 format of tables has changed. #2 non susceptible category
Discussion points 2009 CLSI M100 S19 Update Nebraska Public Health Laboratory Changes most important to routine antimicrobial susceptibility testing. Documents available Janet Hindler discussion slide
More informationReport on susceptibility of Salmonella serotypes in Belgium Vicky Jasson
CODA-CERVA Report on susceptibility of Salmonella serotypes in Belgium 2014. Vicky Jasson Veterinary and Agrochemical Research Centre 1 Introduction Salmonella is one of the most important bacterial zoonotic
More informationAuthor: Souha Kanj Andrew Whitelaw Michael J. Dowzicky. To appear in: International Journal of Antimicrobial Agents
t Title: In vitro activity of tigecycline and comparators against Gram-positive and Gram-negative isolates collected from the Middle East and Africa between 2004 and 2011 Author: Souha Kanj Andrew Whitelaw
More informationAntibacterial activity of nitric oxide (NO) releasing silver nanoparticles (AgNPs)
Antibacterial activity of nitric oxide (NO) releasing silver nanoparticles (AgNPs) Dr Amedea B. Seabra amedea.seabra@ufabc.edu.br Universidade Federal do ABC, Brazil 1 Silver nanoparticles (AgNPs) 2 Silver
More informationABIMMUNE Repurposing disused antibiotics with immune modulators as antimicrobial strategy for respiratory tract infections
ABIMMUNE Repurposing disused antibiotics with immune modulators as antimicrobial strategy for respiratory tract infections Jean-Claude Sirard Christophe Carnoy Fiordiligie Casilag Delphine Cayet The partners
More informationUrinary tract infection. Mohamed Ahmed Fouad Lecturer of pediatrics Jazan faculty of medicine
Urinary tract infection Mohamed Ahmed Fouad Lecturer of pediatrics Jazan faculty of medicine Objectives To differentiate between types of urinary tract infections To recognize the epidemiology of UTI in
More information10/4/16. mcr-1. Emerging Resistance Updates. Objectives. National Center for Emerging and Zoonotic Infectious Diseases. Alex Kallen, MD, MPH, FACP
National Center for Emerging and Zoonotic Infectious Diseases Emerging Resistance Updates Alex Kallen, MD, MPH, FACP Lead Antimicrobial Resistance and Emerging Pathogens Team Prevention and Response Branch
More informationPrevalence of Extended Spectrum -Lactamases In E.coli and Klebsiella spp. in a Tertiary Care Hospital
ISSN: 2319-7706 Volume 3 Number 10 (2014) pp. 474-478 http://www.ijcmas.com Original Research Article Prevalence of Extended Spectrum -Lactamases In E.coli and Klebsiella spp. in a Tertiary Care Hospital
More informationAntioxidant and Antimicrobial Activities of the Extracts of Sophora flavescens
Antioxidant and Antimicrobial Activities of the Extracts of Sophora flavescens Cheng-Hong Yang, Chi-Chun Wu, and Li-Yeh Chuang * Abstract The main goal of this study was to determine the antibacterial
More informationAntibacterial activity and mechanism of ZnO nanoparticles on C. jejuni
Antibacterial activity and mechanism of ZnO nanoparticles on C. jejuni Yiping He Yanping Xie Molecular Characterization of Foodborne Pathogens Research Unit, USDA-ARS ZnO It is stable under high temperatures
More informationDIVISION OF ANTIINFECTIVE DRUG PRODUCTS (HFD-520) CLINICAL MICROBIOLOGY REVIEW NDA Date review completed: 15 Jun 05
Date company submitted: 15 Dec 04 Date received by CDER: 15 Dec 04 Reviewer: Fred Marsik, Ph.D. Date assigned: 15 Dec 04 NAME AND ADDRESS OF APPLICANT Wyeth Pharmaceuticals Inc. P.O. Box 8299 Philadelphia,
More informationMICROBIOLOGICAL PROFILE
Evans Vanodine International plc G L O B A L H Y G I E N E S O L U T I O N S HANDSAN MICROBIOLOGICAL PROFILE 2 INTRODUCTION HANDSAN is a ready to use, quick acting and highly effective, alcohol based hygienic
More informationEffect of efflux pump inhibitors on antimicrobial resistance and in vivo colonization of Campylobacter jejuni
Effect of efflux pump inhibitors on antimicrobial resistance and in vivo colonization of Campylobacter jejuni J. Lin & M. Ensminger Department of Animal Science, The University of Tennessee, Knoxville,
More informationProfessor of Chemotherapy Department of Preclinical and Clinical Pharmacology University of Florence
Professor of Chemotherapy Department of Preclinical and Clinical Pharmacology University of Florence Researching field Pharmacokinetics, Pharmacodynamics of antimicrobial, antifungal and antitumoral drugs
More informationResistance to Polymyxins in France
Resistance to Polymyxins in France Paris Prof. Patrice Nordmann NDM producers in Enterobacteriaceae The polymyxins; colistin and polymyxin B Colistin - Synthesis by Bacillus polymyxa spp colistinus -
More informationBiofilms: Álvaro Pascual MD, PhD Department of Microbiology
Biofilms: Role on Pathogenesis and Treatment of UTIs. Álvaro Pascual MD, PhD Department of Microbiology University of Seville. Spain. Medical devices-related infections 1. 35 millions/year in USA 2. Most
More informationMesporin TM. Ceftriaxone sodium. Rapid onset, sustained action, for a broad spectrum of infections
Ceftriaxone sodium Rapid onset, sustained action, for a broad spectrum of infections 1, 2, 3 Antibiotic with a broad spectrum of activity Broad spectrum of activity against gram-positive* and gram-negative
More informationTRANSPARENCY COMMITTEE. Opinion. 07 January 2009
The legally binding text is the original French version TRANSPARENCY COMMITTEE Opinion 07 January 2009 500 mg, powder for solution for perfusion B/10 bottles (CIP: 387 355-6) Applicant: JANSSEN-CILAG doripenem
More informationSensitivity of Surveillance Testing for Multidrug-Resistant Gram-Negative Bacteria in the
JCM Accepts, published online ahead of print on 20 August 2014 J. Clin. Microbiol. doi:10.1128/jcm.02369-14 Copyright 2014, American Society for Microbiology. All Rights Reserved. 1 2 Sensitivity of Surveillance
More informationDisclosures. Efficacy of the drug. Optimizing Dosing Based on PKPD- An overview. Dose Finding - The Past
Disclosures Optimizing Dosing Based on PKPD- An overview Johan W. Mouton MD PhD FIDSA FAAM Professor pharmacokinetics and pharmacodynamics Research grants advisory boards speaker This Patient Needs Antibiotics.
More informationPHARMACOKINETIC & PHARMACODYNAMIC OF ANTIBIOTICS
PHARMACOKINETIC & PHARMACODYNAMIC OF ANTIBIOTICS SITI HIR HURAIZAH MD TAHIR Bpharm (UKM), MSc (Clinical Microbiology) (UoN) CLINICAL PHARMACIST HOSPITAL MELAKA WHY STUDY PHARMACOKINETICS (PK) AND PHARMACODYNAMICS
More informationAntimicrobial activity of Terminalia chebula
, ISSN 2249 4340 Vol. 1, No. 2, pp. 175-179, September 2011 RESEARCH ARTICLE Antimicrobial activity of Terminalia chebula M. Golam MOSTAFA, Mahdia RAHMAN, M. Manjurul KARIM* Department of Microbiology,
More informationExperimental Endocarditis Caused by Streptococcus sanguis:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, July 1981, p. 1-14 66-484/81/71-5$2./ Vol. 2, No. 1 Experimental Endocarditis Caused by Streptococcus sanguis: Single and Combined Antibiotic Therapy MARIA V. VICENTE,
More informationFERTISAFE PLUS US PL AFE TIS FER
FERTISAFE PLUS FERTISAFE PLUS FERTISAFE PLUS Broad Spectrum Antimicrobial Disinfectant Fertisafe Plus is a long lasting, CE marked, ready to use broad spectrum antimicrobial disinfectant. Quaternary Ammonium
More informationUse of imipenem. with the support of Wallonie-Bruxelles International. Magali Dodémont Microbiology Hospital Erasme Université Libre de Bruxelles
with the support of Wallonie-Bruxelles International Use of imipenem Magali Dodémont Microbiology Hospital Erasme Université Libre de Bruxelles 1 Β-lactams classification 2 Β-lactams: mode of action Inhibition
More informationActivity of tigecycline alone and in combination with colistin and meropenem against carbapenemase
Activity of tigecycline alone and in combination with colistin and meropenem against carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay Spyros Pournaras, Georgia Vrioni, Evangelia
More informationSynergism of Fosfomycin-Ampicillin and Fosfomycin-
ANTIMICROBiAL AGENTS AND CHEMoTHERAPY, May 1978, p. 75-79 66-484/78/13-75$2./ Copyright 1978 American Society for Microbiology Vol. 13, No. 5 Printed in U.S.A. Synergism of Fosfomycin-Ampicillin and Fosfomycin-
More informationCustomary urine test is the dip stick and the mid-stream culture of voided urine. Up to 77% of cystitis cases are cultured
9 million visits/year! Customary urine test is the dip stick and the mid-stream culture of voided urine. Up to 77% of cystitis cases are cultured Interpretation of the culture result has been controversial-
More informationUpdate on CLSI and EUCAST
Update on CLSI and EUCAST 1 Completed work» Cephalosporin breakpoints for Enterobacteriaceae ESBL screens MIC versus resistance mechanism» Carbapenem breakpoints for Enterobacteriaceae Modified Hodge Test»
More informationBasic Concepts of PK/PD -pharmacodynamic indices- Johan W. Mouton MD PhD FIDSA Professor pharmacokinetics and pharmacodymamics
Basic Concepts of PK/PD -pharmacodynamic indices- Johan W. Mouton MD PhD FIDSA Professor pharmacokinetics and pharmacodymamics This patient needs antibiotics. But which ones? Intensive care patient Ceftazidime,
More informationTOUCAN DATA & SCIENCE INFORMATION
TOUCAN DATA & SCIENCE INFORMATION RESEARCH Centrego s Toucan ElectroChemical Activation (ECA) devices generate a powerful sanitizing and disinfecting solution containing hypochlorous acid, the same natural
More informationInfectious Disease Testing. UriSelect 4 Medium. Direct Identification Visibly Reliable
Infectious Disease Testing Urielect 4 Medium Direct Identification Visibly Reliable Urielect 4 Non selective chromogenic medium for the isolation, differentiation and enumeration of urinary tract infections
More informationGuillain-Barré Syndrome
Guillain-Barré Syndrome A Laboratory Perspective Laura Dunn Biomedical Scientist (Trainee Healthcare Scientist) Diagnosis of GBS GBS is generally diagnosed on clinical grounds Basic laboratory studies
More informationThis material is supported in part by unrestricted educational grants from: Abbott, Bayer HealthCare, Merck Frosst, Roche Diagnostics, and Wyeth Inc.
Division of Medical Microbiology Department of Laboratory Medicine and Pathology University of Alberta Hospital and Stollery Children's Hospital Antibiogram 2006 This material is supported in part by unrestricted
More informationAminoglycosides. Not orally absorbed. Interact with negatively charged lipopolysaccharide on Gram- cell wall. Aminoglycoside properties
Aminoglycosides Tobramycin Kanamycin H2N Gentamicin Amikacin NHCOCHCH2CH2NH2 OH Aminoglycosides made of linked sugars. Decorated with many OH and NH2 groups, which render these compounds positively charged
More informationConsultation on the Revision of Carbapenem Breakpoints
Consultation on the Revision of Carbapenem Breakpoints July 2018 Please send comments to the EUCAST Scientific Secretary at jturnidge@gmail.com by September 15. EUCAST revision of carbapenem breakpoints
More informationMicrosan rx Anti-Microbial Healthcare Professional Soap. Organism Positives ATCC #
: Contact Time: 30 seconds 17,500 ppm. PCMX active Organism Positives ATCC # Acinetobacter calcoaceticus var. anitratus 0 s Acinetobacter calcoaceticus var. woffii 0 s Actinobacillus pleuropneumonia 0
More informationUTI : A NEW APPROACH TO ITS DIAGNOSIS
Abstract UTI : A NEW APPROACH TO ITS DIAGNOSIS Pages with reference to book, From 126 To 129 S. Hafiz, N. Lyall ( Department of Microbiology, The Aga Khan University Hospital, Karachi. ) The incidence
More informationActivity of Ceftolozane/Tazobactam Against a Broad Spectrum of Recent Clinical Anaerobic Isolates
AAC Accepts, published online ahead of print on 25 November 2013 Antimicrob. Agents Chemother. doi:10.1128/aac.02253-13 Copyright 2013, American Society for Microbiology. All Rights Reserved. Activity
More informationSMT19969: A Selective Therapy for C. difficile Infection
SMT19969: A Selective Therapy for C. difficile Infection One Bug, One Drug 25 th September 2012 SMT19969: A Selective Therapy for CDI SMT19969 is a novel antibiotic for the specific treatment of Clostridium
More informationINFECTIOUS DISEASE. Page 2
Infectious disease Advantages OF TESTING INFECTIOUS DISEASE We are in the middle of a paradigm shift in infectious disease diagnostic testing. As we move from targeted infectious disease testing to a syndromic
More information