Novel treatment for castration-resistant prostate cancer
|
|
- Arthur Townsend
- 5 years ago
- Views:
Transcription
1 Novel treatment for castration-resistant prostate cancer Cora N. Sternberg, MD, FACP Chair, Department of Medical Oncology San Camillo and Forlanini Hospitals Rome, Italy
2 Treatment options for patients with CRPC Zoledronic Acid 1 Sipuleucel-T 3 Docetaxel 2 Cabazitaxel 4 Denosumab 5 Abiraterone The near future MDV31 7 Alpharadin 8 1 Saad et al. J Natl Cancer Inst 22; 94: Tannock et al. N Engl J Med 24;351(15): Kantoff et al. N Engl J Med 21; 363(5): de Bono et al. Lancet. 21; 376(9747): Fizazi et al. Lancet 211; 377(9768): de Bono et al. N Engl J Med 211; 346(21): Scher et al. GU ASCO 212 (abst) 8 Parker et al. ESMO 211 (abst)
3 Challenges to Developing New Drugs for Advanced Prostate Cancer
4 Bone Metastases Are Difficult to Evaluate Pathologic Fracture Radiotherapy to Bone Surgery to Bone Spinal Cord Compression Skeletal-Related Events (SREs)
5 Bone Flare With PSA Decline Ryan CJ, et al. Clin Cancer Res. 211;17:
6 Challenges to Developing New Drugs for Advanced Prostate Cancer OS only accepted outcome measure PSA Circulating tumor cells (CTC) Disseminated tumor cells (DTC) Cancer stem cells (CSC) Inter-patient molecular heterogeneity ETS gene rearrangements (4%-7%) PTEN loss cancers (>5%) RAF rearrangements (~5%) BRCA carrier cancers (<1%) PCWG2* (Prostate Working Group Guidelines 2) Lack of surrogate markers * 1 Scher HI et al. J Clin Oncol. 28;26:
7 Fall in Circutating Tumor Cells (CTC) Count (>5 to <5) Associated With Improved OS Median OS in Probability of Survival (%) Group 1 Group 2 Group 3 Group 4 Curve Log-rank Comparison P-Value* 1 vs vs 3 <.1 1 vs 4 <.1 2 vs 3 <.1 2 vs 4 <.1 3 vs Time from Baseline Blood Draw (Months) *P-values not adjusted for multiple hypothesis tests Group Description N (%) Months (95% CI) 1 <5 CTC at all draws 88 (38) >26 (21.4 to ) 2 > 5 CTC at BL & <5 CTC at last draw 45 (2) 21.3 (18.4 to ) 3 <5 CTC at early draw & > 5 CTC at last draw 26 (11) 9.3 (8.2 to 11.3) 4 > 5 CTC at all draws 71 (31) 6.8 (5.8 to 1.3) Cox HR (95% CI) = 2.2 ( ) chi-square = 11.9 (P-value <.1) No. of Patients Still at Risk m 6.8m de Bono JS et al. Clin Cancer Res. 28;14:
8 Targeting the Androgen Receptor (AR)
9 Direct Measurement of Tissue Androgens Confirm the Presence of Sufficient Levels to Activate the Receptor
10 The New Antiandrogens Abiraterone Acetate (Phase 3 studies post- and pre-docetaxel) - Potent and selective inhibitor of CYP17-α-hydroxylase and C17,2-lyase MDV31 (Phase 3 studies post- and pre-docetaxel) - AR antagonist, inhibits nuclear translocation and blocks DNA binding of the receptor and activation TAK-7 (Phase 3 studies post- and pre-docetaxel) - Selective, nonsteroidal, small-molecule inhibitor of 17,2-lyase TOK-1 (Phase 1/2 ARMOR1) - AR antagonist, and AR degrader, and a CYP17 lyase inhibitor SARDS - Selective androgen receptor degraders (destroy the AR receptor) ARN-59 (Phase 1/2) - AR antagonist, inhibits nuclear translocation and DNA binding of the receptor Co-factor antagonists -Target coactivator interaction surfaces AR antagonists
11 Abiraterone Inhibits Androgen Biosynthesis Through CYP17 Androgens produced at 3 critical sites Testes Adrenal gland Prostate tumor cells Abiraterone inhibits biosynthesis of androgens that stimulate tumor cell growth PSA and radiographic responses in Phase 2 studies of CRPC Chemo-naïve and post-chemo patients Attard G et al. J Clin Oncol. 28;26: ; 2. Attard G et al. J Clin Oncol. 29;27: ; 3. Reid AH et al. J Clin Oncol. 21;28: ; 4. Ryan CJ et al. J Clin Oncol. 21;28: ; 5. Danila DC et al. J Clin Oncol. 21;28: ; 6. de Bono JS et al. Ann Oncol. 21;21(suppl 8): Abstract LBA5.
12 CRPC: Suppression of androgen levels LHRH agonists LH ACTH Abiraterone Testosterone Androstenedione Ligand-dependent Receptor tyrosine kinase Ligand-independent 4 Ligand-independent activation of AR Abiraterone 1 2 Alternate ligands Nuclear localisation Transcription Nucleus Coactivators Corepressors AR splice variants Cytoplasm
13 Abiraterone Acetate Phase 3 Post-Chemo Study Design Efficacy endpoints (ITT) 1195 patients with progressive mcrpc Failed 1 or 2 chemotherapy regimens, 1 with docetaxel R A N D O M I Z E D 2:1 Abiraterone 1 mg daily Prednisone 5 mg bid n = 797 Placebo daily Prednisone 5 mg bid n = endpoint: OS (25% improvement; HR.8) 2 nd endpoints: TTPP rpfs PSA response Phase 3 multicenter, randomized, double-blind, placebo-controlled study (147 sites in 13 countries; USA, Europe, Australia, Canada) Stratification by: ECOG performance status -1 vs 2 Worst pain over previous 24 hours Prior chemotherapy 1 vs 2 BPI short form; -3 (absent) vs 4-1 (present) Type of progression PSA only vs radiographic with or without PSA de Bono JS et al. N Engl J Med. 211;364:
14 Baseline demographics (N=1195) AA (n=797) Placebo (n=398) Median age, years (range) 69. (42-95) 69. (39-9) Caucasian 93% 92.7% ECOG-PS 2 1% 11% Significant pain present 45% 45% 2 prior chemotherapies 3% 31% Radiographic progression 7% 69% de Bono et al. N Engl J Med 211; 346(21):
15 Disease sites and baseline laboratory parameters Extent of disease AA (n=797) Placebo (n=398) Bone 89% 9% Node 45% 41% Liver 11% 8% Lung 13% 11% PSA (median, ng/ml) Hemoglobin (median, g/dl) Alkaline phos (median, IU/L) LDH (median, IU/L) de Bono et al. N Engl J Med 211; 346(21):
16 Overall survival: Interim analysis Survival (%) HR (95% CI):.65 ( ) p<.1 Placebo: 1.9 months (95% CI, ) AA Placebo Abiraterone acetate: 14.8 months (95% CI, ) Median follow-up 12.8 months Time to Death (Months) AA Placebo de Bono et al. N Engl J Med 211; 346(21):
17 Overall survival: second pre-planned analysis (775 Events) 1 Median OS benefit of AA from 3.9 to 4.6 months Survival (%) Placebo median OS (95% CI): 11.2 months ( ) HR (95% CI):.74 ( ) p<.1 AA median OS (95% CI): 15.8 months ( ) Placebo AA Median follow-up 2.2 months Time to Death (Months) AA Placebo Scher et al. J Clin Oncol 211; 29 (suppl): Abstract LBA4517
18 Survival Benefit Consistently Observed Across Patient Subgroups Variable Subgroup N HR 95% CI All subjects All Baseline ECOG Baseline BPI < No of prior chemotherapy regimens Type of progression PSA only Radiographic Age, years < Visceral disease at entry Yes Baseline PSA above median Yes Baseline LDH above median Yes Baseline ALK-P above median Yes Region N America Other Favors AA Favors placebo de Bono et al. N Engl J Med 211; 346(21):
19 Survival By Baseline Stratification Factors: Prior Chemotherapy 1 prior line of chemotherapy 2 prior lines of chemotherapy 1 1 Survival (%) Abiraterone acetate: 15.4 months Survival (%) Abiraterone acetate: 14. months 2 AA Placebo Placebo: 11.5 months Time to Death (Months) 2 AA Placebo Placebo: 1.3 months Time to Death (Months) Median overall survival - Abiraterone acetate (AA) vs placebo 1 prior line of chemotherapy: 15.4 vs 11.5 months 2 prior lines of chemotherapy: 14. vs 1.3 months se Bono JS, et al. ESMO 21; Abstract P135. Scher HI, et al. ASCO GU 211; Abstract 4.
20 Survival By Baseline Stratification Factors: ECOG Status Survival (%) Placebo: 7 months AA, ECOG -1 Placebo, ECOG -1 AA, ECOG 2 Placebo, ECOG 2 Eastern Cooperative Oncology Group (ECOG) status (-1 vs 2) AA: 7.3 months Placebo: 11.7 months Abiraterone acetate: 15.3 months Time to Death (Months) Median overall survival - Abiraterone acetate (AA) vs placebo ECOG -1: 15.3 vs 11.7 months ECOG 2: 7.3 vs 7 months Scher HI, et al. ASCO GU 211; Abstract 4.
21 Survival By Baseline Stratification Factors: Pain 1 Pain (-3 [absent]) 1 Pain (4-1 [present]) Survival (%) Placebo: 2 13 months AA Placebo Time to Death (Months) Abiraterone acetate: 16.2 months Survival (%) Placebo: 8.9 months Abiraterone acetate: 12.6 months AA Placebo Time to Death (Months) Median overall survival - Abiraterone acetate (AA) vs placebo Without pain: 16.2 months vs 13 months With pain: 12.6 months vs 8.9 months Scher HI, et al. ASCO GU 211; Abstract 4.
22 All Secondary End Points Achieved Statistical Significance AA (n = 797) Placebo (n = 398) HR (95% CI) P Value TTPP (months) (.46,.73) rpfs (months) (.59,.78) <.1 <.1 ORR (%) a 14. (n=55/392) 2.8 (n=5/181) 5.1 b ( ) <.1 PSA response rate Total 38.% 1.1% <.1 Confirmed 29.1% 5.5% <.1 a RECIST in subjects with measureable disease t baseline; b relative risk; AA, abiraterone acetate; CI, confidence interval; HR, hazard ratio; PSA, ORR, objective response rate; prostate-specific antigen; TTPP, time to PSA progression; rpfs, radiographic progression-free survival.
23 Survival benefit in patients with favorable and unfavorable CTC counts at baseline Proportion Survival Baseline CTC <5 Sample Size: AA CTC <5 314 Placebo CTC <5 141 AA Median (95% CI): 22.1 Months ( ) Placebo Median (95% CI): 19.7 Months (16.7-not estimable) Overall Survival (Months) Placebo AA N=972 a Proportion Survival Baseline CTC 5 AA Median (95% CI): 1.9 Months ( ) Placebo Median (95% CI): 8.2 Months ( ) Overall Survival (Months) Placebo Sample Size: AA CTC Placebo CTC AA N=972 a a Missing baseline CTC patients excluded a Missing baseline CTC patients excluded Scher et al. J Clin Oncol 211; 29 (suppl): Abstract LBA4517
24 Higher conversion rates from unfavorable ( 5 CTC) to favorable (<5 CTC) Week 4 Week 8 Week 12 No. of patients with baseline CTC 5 and a postbaseline CTC value Conversion status AA (n=272) Placebo (n=15) AA (n=245) Placebo (n=129) AA (n=217) Placebo (n=113) Conversion 42% 14% 5% 17% 48% 17% (n) (113) (21) (123) (22) (15) (19) p value <.1 <.1 <.1 p value from chi-square statistic Scher et al. J Clin Oncol 211; 29 (suppl): Abstract LBA4517)
25 Adverse Events of Special Interest AA (n = 791) All Grades Grades 3/4 Placebo (n = 394) All Grades Grades 3/4 Fluid retention 3.5% 2.3% 22.3% 1.% Hypokalemia 17.1% 3.8% 8.4%.8% LFT abnormalities 1.4% 3.5% 8.1% 3.% Hypertension 9.7% 1.3% 7.9%.3% Cardiac 13.3% 4.1% 1.4% 2.3% disorders a A Most frequently reported cardiac terms were tachycardia and atrial fibrillation. The rate of grade 5 lethal cardiac events was identical in the 2 study arms: 1.3% (1 pts) in AA and 1.3% (5 pts) in placebo.
26 Symptomatic Improvement: Pain Intensity Palliation (BPI) Brief Pain Inventory Questionnaire Patients Experiencing Palliation 7% 6% 5% 4% 3% 2% 1% % P =.2 155/349 (44.4%) 44/163 (27.%) Abiraterone Acetate Placebo Logothetis C, et al. ASCO 211; Abstract 452.
27 Pain Alteration and Improvement Study Regimen Pain scale Response definition with Caveats N Pain response Duration Tannock, JCO, 1996 Mito/pred vs. pred PPI 2 point reduction for 3 weeks % vs. 12% p=.1 43 weeks vs. 18 weeks p<.1 TAX 327, Tannock NEJM Doce/pred vs. Mito/pred PPI 2 point reduction for 3 weeks 16 (45% with pain) 35% vs. 22% p=.1 (q 3 week arm) 3.5 vs. 4.8 mos (no difference) TROPIC, Sartor Lancet 21 CBZ/pred vs. mito/pred PPI 2 point reduction for 3 weeks 755 (45% with pain) 9.2% vs. 7.7% p=.63 Median time to pain progression not reached Cougar 31, Logothetis, ASCO 211 Abi/pred vs. placebo/pred BPI 3% reduction from baseline over 4 weeks 1195 (44% with pain) 44.4% vs. 27% p=.2 25 th percentile: 8 mos vs. 5 mos p=.56
28 Pain Alteration and Improvement Study Regimen Pain scale Response definition with Caveats N Pain response Duration Tannock, JCO, 1996 Mito/pred vs. pred PPI 2 point reduction for 3 weeks % vs. 12% p=.1 43 weeks vs. 18 weeks p<.1 TAX 327, Tannock NEJM Doce/pred vs. Mito/pred PPI 2 point reduction for 3 weeks 16 (45% with pain) 35% vs. 22% p=.1 (q 3 week arm) 3.5 vs. 4.8 mos (no difference) TROPIC, Sartor Lancet 21 CBZ/pred vs. mito/pred PPI 2 point reduction for 3 weeks 755 (45% with pain) 9.2% vs. 7.7% p=.63 Median time to pain progression not reached Cougar 31, Logothetis, ASCO 211 Abi/pred vs. placebo/pred BPI 3% reduction from baseline over 4 weeks 1195 (44% with pain) 44.4% vs. 27% p=.2 25 th percentile: 8 mos vs. 5 mos p=.56
29 Pain Alteration and Improvement Clinical benefit with AA over placebo for treatment of bone metastases: Improved pain palliation Delayed pain progression Delayed time to SRE Effect sustained over treatment cycles. Logothetis C, et al. ASCO 211; Abstract 452.
30 Fatigue Analysis: Abiraterone Significantly Improved Fatigue Outcomes AA + prednisone (n = 797) Placebo + prednisone (n = 398) P =.1 P = /384 75/186 13/189 35/92 Baseline Brief Fatigue Inventory (BFI) scores for all items on the questionnaire were not different between groups: Fatigue intensity a : 3.78 vs 3.62 for AA + prednisone vs P + prednisone (P =.278) Fatigue interference b : 3.5 vs 2.9 for AA + prednisone vs P + prednisone (P =.444) AA + prednisone - significantly better fatigue outcomes (fatigue intensity and fatigue interference) more rapidly than placebo and prednisone a Item 3 on the BFI questionnaire. b Average of items 4A-4F on the BFI questionnaire. Sternberg CN, et al. ESMO, 211, September 23-27, 211. Abstract 7.15
31 Fatigue Analysis: Progression of Both Fatigue Intensity and Interference Were Significantly Delayed AA + prednisone (n = 797) Placebo + prednisone (n = 398) A B Proportion without fatigue progression (intensity) th Percentile: 139 days 25 th Percentile: 232 days P <.1 HR:.67 ( ) Proportion without fatigue progression (interference) th Percentile: 139 days 25 th Percentile: 281 days P <.1 HR:.67 ( ) Time (Days) Time (Days) Abiraterone significantly delayed progression of both fatigue intensity and interference Sternberg CN, et al. ESMO, 211, September 23-27, 211. Abstract 7.15
32 Abiraterone Delayed Time to Deterioration of Quality of Life AA + prednisone (n = 797) Placebo + prednisone (n = 398) Median Time to Decline (Days) * * P =.325 * * * * * WB, well-being; FACT-P, Functional Assessment of Cancer Therapy-general quality of life; PCS, Prostate Cancer Subscale; TOI, Trial Outcome Index. *P <.1 Harland S, et al. ESMO, 211, September 23-27, 211, Stockholm, Sweden. Abstract 7.1
33 Clinical Need in CRPC An intervention with little or no toxicity compared to chemotherapy for asymptomatic or mildly symptomatic CRPC Aim to prevent or delay the onset of pain related to metastatic disease and disease progression Prolong survival
34 Abiraterone in pre-chemotherapy setting Anti-tumor activity in phase 1/2: Prechemotherapy (n = 42) 5% PSA decline 67% Radiological findings Partial response 37.5% Stable disease 66% Favorable CTC conversion Phase 1/2 59% Median TTPP (days) 225 n = 1 Asymptomatic or mildly symptomatic patients with CRPC Phase 3 COU-AA-32 is a phase 3 randomised, double-blind, placebocontrolled trial in CRPC patients pre-chemotherapy Co-primary endpoints: OS and PFS R 1:1 Abiraterone 1 mg qd + prednisone 5 mg bid Placebo qd + prednisone 5 mg bid CTC, circulating tumor cell TTPP, median time to PSA progression Accrual completed 4/29 NCT
35 Phase 3 Trial of Abiraterone Acetate in Asymptomatic or Mildly Symptomatic mcrpc Pre-Chemotherapy (n = 1) mcrpc ECOG PS or 1 bone mets or lymph nodes R A N D O M I Z E 1:1 Abiraterone acetate, 1 mg/day + prednisone/prednisolone 5 mg PO bid Prednisone/prednisolone 5 mg PO bid + placebo Primary endpoint: OS and PFS Secondary: clinical improvement, safety profile, PK Accrual completed 4/29 NCT
36 How will new hormonal treatments be integrated into the treatment schema? Abiraterone (COU-AA-32) MDV31 (PREVAIL) TAK-7 (NCT ) Tasquinimod (NCT ) Ipilimumab (NCT15781) Radium-223 (ALSYMPCA) Not approved Approved Custirsen (SYNERGY) Cabazitaxel (FIRSTANA) Dasatinib (NCT744497) Aflibercept (VENICE) Docetaxel (TAX 327) Mitoxantrone (TAX 327) MDV31 (AFFIRM interim) Ipilimumab (NCT861614) TAK-7 (NCT ) Radium-223 (ALSYMPCA) Cabazitaxel (TROPIC) Abiraterone (COU-AA-32) No metastases Metastases Pre-docetaxel Docetaxel Post-docetaxel Death
37 Conclusions in mcrpc Unequivocal evidence of continued involvement of the AR signaling axis Abiraterone prolongs OS in mcrpc - who have progressed after docetaxel-based chemotherapy - 26% risk reduction of death (HR =.74) Abiraterone significantly improves TTPP, rpfs, and PSA response rate Prostate cancer is not yet a chronic disease, but we are making progress! Stermnberg CN, ESMO Presidential symposium October 21
Androgens and prostate cancer: insights from abiraterone acetate and other novel agents
Androgens and prostate cancer: insights from abiraterone acetate and other novel agents Ian Davis Ludwig Institute for Cancer Research Austin Health, Melbourne, Australia Supported in part by an Australian
More informationUntil 2004, CRPC was consistently a rapidly lethal disease.
Until 2004, CRPC was consistently a rapidly lethal disease. the entry in systemic disease is declared on a an isolated PSA recurrence after local treatment so!!! The management of CRPC and MCRPC is different
More informationEvolution or revolution in the treatment of prostate cancer
Evolution or revolution in the treatment of prostate cancer de Johann Sebastian de Bono, MB, ChB, FRCP, MSc, PhD Professor of Experimental Cancer Medicine Department of Medicine/ Drug Development Unit
More informationHormonal Manipulations in CRPC. NW Clarke Professor of Urological Oncology Manchester UK
Hormonal Manipulations in CRPC NW Clarke Professor of Urological Oncology Manchester UK Standard Treatment of CRPC Pre 2004 (and in 2013?) PSA progression 99m Tc BS negative CT scan large lymph node component
More informationProstate Cancer 2009 MDV Anti-Angiogenesis. Anti-androgen Radiotherapy Surgery Androgen Deprivation Therapy. Docetaxel/Epothilone
Prostate Cancer 2009 Anti-Angiogenesis MDV 3100 Anti-androgen Radiotherapy Surgery Androgen Deprivation Therapy Docetaxel/Epothilone Abiraterone DC therapy Bisphosphonates Denosumab Secondary Hormonal
More informationSESSIONE PLATINUM SERIES (Best Papers Poster o Abstract on Prostate Cancer) In Oncologia
SESSIONE PLATINUM SERIES (Best Papers Poster o Abstract on Prostate Cancer) In Oncologia Divisione di Oncologia Medica Unità Tumori Genitourinari SESSIONE PLATINUM SERIES (Best Papers Poster o Abstract
More informationManagement of castrate resistant disease; after first line hormone therapy fails
Management of castrate resistant disease; after first line hormone therapy fails Dr. Syed A Hussain Clinical Senior Lecturer and Consultant in Medical Oncology University of Liverpool and Clatterbridge
More informationwww.drpaulmainwaring.com Figure 1 Androgen action Harris W P et al. (2009) Nat Clin Pract Urol doi:10.1038/ncpuro1296 Figure 2 Mechanisms of castration resistance in prostate cancer Harris W P et al. (2009)
More informationManagement of castrate resistant disease: after first line hormone therapy fails
Management of castrate resistant disease: after first line hormone therapy fails Rob Jones Consultant in Medical Oncology Beatson Cancer Centre Glasgow Relevant Disclosure I have received research support
More informationSequencing Strategies in Metastatic Castration Resistant Prostate Cancer (MCRPC)
Sequencing Strategies in Metastatic Castration Resistant Prostate Cancer (MCRPC) Amit Bahl Consultant Oncologist Bristol Cancer Institute Clinical Director Spire Specialist Care Centre UK Disclosures Advisory
More informationSecond line hormone therapies. Dr Lisa Pickering Consultant Medical Oncologist ESMO Preceptorship Singapore 2017
Second line hormone therapies Dr Lisa Pickering Consultant Medical Oncologist ESMO Preceptorship Singapore 2017 Disclosures Institutional Research Support/P.I. Employee Consultant Major Stockholder Speakers
More informationPerspective on endocrine and chemotherapy agents. Cora N. Sternberg Department of Medical Oncology San Camillo & Forlanini Hospitals Rome, Italy
Perspective on endocrine and chemotherapy agents Cora N. Sternberg Department of Medical Oncology San Camillo & Forlanini Hospitals Rome, Italy Disclosures Dr. Sternberg has received research funding for
More informationLONDON CANCER NEW DRUGS GROUP RAPID REVIEW
LONDON CANCER NEW DRUGS GROUP RAPID REVIEW Abiraterone for the treatment of metastatic castration-resistant prostate cancer that has progressed on or after a docetaxel-based chemotherapy regimen Disease
More informationStrategic decisions for systemic treatment. metastatic castration resistant prostate cancer (mcrpc)
Strategic decisions for systemic treatment metastatic castration resistant prostate cancer (mcrpc) SAMO Luzern 14.09.2012 Richard Cathomas Onkologie Kantonsspital Graubünden richard.cathomas@ksgr.ch mcrpc
More informationAdvanced Prostate Cancer
Advanced Prostate Cancer SAMO Masterclass 4 th March 2016 Aurelius Omlin Conflicts of interest Advisory Rolle: Astra Zeneca, Astellas, Bayer, Janssen, Pfizer, Sanofi Aventis Research support: TEVA, Janssen
More informationManagement of Incurable Prostate Cancer in 2014
Management of Incurable Prostate Cancer in 2014 Julie N. Graff, MD, MCR Portland VA Medical Center Assistant Professor of Medicine Knight Cancer Institute, OHSU 2014: Cancer Estimates Stage at Diagnosis
More informationSOGUG meeting New drugs after docetaxel chemotherapy in patient with mcrpc
SOGUG meeting New drugs after docetaxel chemotherapy in patient with mcrpc Stéphane OUDARD, MD, PhD Head of the Oncology department Georges Pompidou Hospital, Paris France University Rene Descartes, Paris
More information2014 Treatment Paradigms in mcrpc Docetaxel in hormone sensitive PC
Ronald de Wit Erasmus MC Cancer Institute The Netherlands 2014 Treatment Paradigms in mcrpc Docetaxel in hormone sensitive PC Disclosures Sanofi ; research grant support, consultancy and speaker fees Astellas;
More informationWhat will change for men with advanced prostate cancer in the next 24 months? ESO Observatory: Perspective on endocrine and chemotherapy agents
Perspective on endocrine and chemotherapy agents Cora N. Sternberg Department of Medical Oncology San Camillo & Forlanini Hospitals Rome, Italy Disclosures Dr.Sternberg has received research funding for
More informationIndex Patients 3& 4. Guideline Statements 10/11/2014. Enzalutamide Reduced the Risk of Death
//4 Prolonged Radiographic Progression-Free Survival Reduced the Risk of Death Overall ITT Population Estimated median rpfs, months (9% CI): : NYR (.8 NYR); placebo:.9 (.7.4) rpfs (%) ( Enza 9 8 7 4 8
More informationMapping the Complexity of Androgen Signaling In Prostate Cancer Progression Eleni Efstathiou MD PhD
Mapping the Complexity of Androgen Signaling In Prostate Cancer Progression Eleni Efstathiou MD PhD The University of Athens Medical School Dept of Clinical Therapeutics Prostate Cancer Evolution Chemotherapy
More informationCirculating tumor cells as biomarker for hormonal treatment in breast and prostate cancer. Michal Mego
National Cancer Institute, Slovakia Translational Research Unit Circulating tumor cells as biomarker for hormonal treatment in breast and prostate cancer Michal Mego 2 nd Department of Oncology, Faculty
More information8/31/ ) Intermittent androgen deprivation in androgen-sensitive PCa. 1) Alpharadin (Ra223) in CRPC with bone metastases
Bruce J. Roth, M.D. Clinical Trials: Medivation, Oncogenix 1) Alpharadin (Ra223) in CRPC with bone metastases 2) Enzalutamide (MDV-31) in CRPC and prior docetaxel 3) Abiraterone in chemo-naïve CRPC 4)
More informationManagement of castration resistant prostate cancer after first line hormonal therapy fails
Management of castration resistant prostate cancer after first line hormonal therapy fails Simon Crabb Senior Lecturer in Medical Oncology University of Southampton WHAT ARE THE AIMS OF TREATMENT? Cure?
More informationGroup Sequential Design: Uses and Abuses
Group Sequential Design: Uses and Abuses Susan Halabi Department of Biostatistics and Bioinformatics, Duke University October 23, 2015 susan.halabi@duke.edu What Does Interim Data Say? 2 Group Sequential
More informationWhen exogenous testosterone therapy is. adverse responses can be induced.
Theoretical tips It has been reasoned that discontinuation of ADT in nonorchiectomized patients may have detrimental effect on patients with CRPC as discontinuation of ADT can result in renewed release
More informationSYSTEMIC THERAPIES FOR CRPC: Chemotherapy and Radium-223
SYSTEMIC THERAPIES FOR CRPC: Chemotherapy and Radium-223 ELENA CASTRO Spanish National Cancer Research Centre Prostate Preceptorship. Lugano 4-5 October 2018 Disclosures Participation in advisory boards:
More informationAdvanced Prostate Cancer. November Jose W. Avitia, M.D
Advanced Prostate Cancer November 4 2017 Jose W. Avitia, M.D In 2017 161,000 new cases of prostate cancer diagnosed in US, mostly with elevated PSA 5-10% will present with metastatic disease In 2017: 26,000
More informationPublished on The YODA Project (
Principal Investigator First Name: David Last Name: Lorente Degree: MD Primary Affiliation: Medical Oncology Service, Hospital Provincial de Castellón E-mail: lorente.davest@gmail.com Phone number: +34
More informationASCO 2012 Genitourinary tumors
ASCO 2012 Genitourinary tumors Post ASCO Bern 14-06-2012 Dr. med. Richard Cathomas leitender Arzt Onkologie, KSGR, Chur Renal cell cancer Changes in first line treatment? Prostate cancer 3 positive phase
More informationHave we optimized the use of Androgen Receptor pathway targeted drugs in Castrate-Resistant Prostate Cancer?
Have we optimized the use of Androgen Receptor pathway targeted drugs in Castrate-Resistant Prostate Cancer? Karim Fizazi, MD, PhD Institut Gustave Roussy Villejuif, France Disclosure Participation to
More informationSecondary Hormonal therapies in mcrpc
Secondary Hormonal therapies in mcrpc Ravindran Kanesvaran Consultant,Division of Medical Oncology National Cancer Centre Singapore 1 Disclosures Research Support/P.I. Sanofi Consultant Major Stockholder
More informationSUMMARY. 3. Emerging understanding of mechanisms of resistance to current treatments
SUMMARY 1. Discuss the active agents in prostate cancer currently available in Australia 2. Celebrate the growing role for Prostate Medical Oncologists in Multi Disc Teams active treaments overall survival
More informationIncorporating New Agents into the Treatment Paradigm for Prostate Cancer
Incorporating New Agents into the Treatment Paradigm for Prostate Cancer Dr. Celestia S. Higano FACP, Professor, Medicine and Urology, Uni. of Washington Member, Fred Hutchinson Cancer Research Center
More informationNavigating Prostate Cancer Therapy. Nevin Murray MD Clinical Professor of Medicine, UBC Medical Oncologist, BCCA
Navigating Prostate Cancer Therapy Nevin Murray MD Clinical Professor of Medicine, UBC Medical Oncologist, BCCA Disclosures In compliance with accreditation, we require the following disclosures to the
More informationSummary of Phase 3 IMPACT Trial Results Presented at AUA Meeting Webcast Conference Call April 28, Nasdaq: DNDN
Summary of Phase 3 IMPACT Trial Results Presented at AUA Meeting Webcast Conference Call April 28, 2009 Nasdaq: DNDN PROVENGE sipuleucel-t is an autologous active cellular immunotherapy that activates
More informationPLAATS VAN DE CHEMOTHERAPIE IN DE BEHANDELING VAN EEN PROSTAATCARCINOOM: EEN UPDATE. Daan De Maeseneer, Medisch Oncoloog
PLAATS VAN DE CHEMOTHERAPIE IN DE BEHANDELING VAN EEN PROSTAATCARCINOOM: EEN UPDATE Daan De Maeseneer, Medisch Oncoloog 1 Overview DEAT PSA/Tumor Burden METASTASES INITIAL DIAGNOSIS & THERAPY ADT CRP SREs/
More informationAdvanced Prostate Cancer
Advanced Prostate Cancer January 13, 2017 Sindu Kanjeekal MD FRCPC Medical Oncology and Hematology Regional Systemic Quality Lead Erie St Clair Adjunct Professor Schulich School of Medicine and University
More informationPROSTATE CANCER HORMONE THERAPY AND BEYOND. Przemyslaw Twardowski MD Professor of Oncology Department of Urologic Oncology John Wayne Cancer Institute
PROSTATE CANCER HORMONE THERAPY AND BEYOND Przemyslaw Twardowski MD Professor of Oncology Department of Urologic Oncology John Wayne Cancer Institute Disclosures I am a Consultant for Bayer and Sanofi-Aventis
More informationJoelle Hamilton, M.D.
Joelle Hamilton, M.D. www.urologycentersalabama.com Case Presentation: CRPC, Rising PSA 70 yo healthy, fit, active man post RALP 8 years prior with rising PSA Rising PSA from 0.02 nadir to 3.4 thus ADT
More informationNew Treatment Modalities and Clinical Trials for HRPC 계명의대 김천일
New Treatment Modalities and Clinical Trials for HRPC 계명의대 김천일 Castrate-Resistant Prostate Cancer (CRPC) Current standard therapy Androgen receptor (AR) in CRPC New systemic therapies Hormonal therapy
More informationProstate cancer update: Dr Robert Huddart Cancer Clinic London
Prostate cancer update: 2013 Dr Robert Huddart Cancer Clinic London Recent developments Improved imaging New radiotherapy technologies Radiotherapy for advanced disease Intermittent hormone therapy New
More information- La Terapia Farmacologica -
XXV Congresso Nazionale AIRO Simposio AIRO-AIMN: Trattamento delle Metastasi Ossee nel Paziente con Tumore della Prostata "Ormonorefrattario": - La Terapia Farmacologica - Sergio Bracarda, Medical Oncology
More informationAdvanced Prostate Cancer. SAMO Masterclass 17 th of March 2017 PD Dr. med. Aurelius Omlin
Advanced Prostate Cancer SAMO Masterclass 17 th of March 2017 PD Dr. med. Aurelius Omlin aurelius.omlin@kssg.ch Conflicts of Interest Research Support: TEVA, Janssen Advisory Rolle: Astra Zeneca, Astellas,
More informationASCO 2011 Genitourinary Cancer
ASCO 2011 Genitourinary Cancer Expanding Options for Chronic Diseases? Walter Stadler, MD, FACP University of Chicago Disclosures (All Non-University &/or Financial Dealings with Potential, Real, or Perceived
More informationManagement Options in Advanced Prostate Cancer: What is the Role for Sipuleucel-T?
Clinical Medicine Insights: Oncology Consise Review Open Access Full open access to this and thousands of other papers at http://www.la-press.com. Management Options in Advanced Prostate Cancer: What is
More informationSUPPLEMENTARY APPENDIX. COU-AA-301 enrolled men with pathologically confirmed mcrpc who had received previous
SUPPLEMENTARY APPENDIX Methods Subjects COUAA30 enrolled men with pathologically confirmed mcrpc who had received previous treatment with docetaxel chemotherapy and had documented PSA progression according
More informationManagement of castrate resistant disease: after first line hormone therapy fails
Management of castrate resistant disease: after first line hormone therapy fails Rob Jones Consultant in Medical Oncology Beatson Cancer Centre Glasgow Rhona McMenemin Consultant in Clinical Oncology The
More informationNew Treatment Options for Prostate Cancer
New Treatment Options for Prostate Cancer Moderator: Jeremy P. Goldberg, President, JPG Healthcare LLC Panelists: Philip Kantoff, MD, Director, Lank Center for Genitourinary Oncology, Dana- Farber Cancer
More informationPatients Living Longer: The Promise of Newer Therapies
Patients Living Longer: The Promise of Newer Therapies David M. Nanus, MD! Chief, Division of Hematology and Medical Oncology! Weill Cornell Medicine! New York Presbyterian Hospital!! Demographics 180,890
More informationWhen exogenous testosterone therapy is. adverse responses can be induced.
Theoretical tips It has been reasoned that discontinuation of ADT in non orchiectomized patients may have detrimental effect on patients with CRPC as discontinuation of ADT can result in renewed release
More informationSession 4 Chemotherapy for castration refractory prostate cancer First and second- line chemotherapy
Session 4 Chemotherapy for castration refractory prostate cancer First and second- line chemotherapy October- 2015 ESMO 2004 October- 2015 Fyraftensmøde 2 2010 October- 2015 Fyraftensmøde 3 SWOG 9916 OS
More informationAnti-Androgen Therapies for Prostate Cancer: A Focused Review
Anti-Androgen Therapies for Prostate Cancer: A Focused Review Nischala Ammannagari, MD, and Saby George, MD, FACP Abstract Among men in the United States, prostate cancer is the most common malignancy
More informationManagement of Prostate Cancer
Management of Prostate Cancer An ESMO Perspective Alan Horwich Conflicts of Interest Disclosure Alan Horwich I have no personal conflicts of interest relating to prostate cancer. European Incidence and
More informationLower Baseline PSA Predicts Greater Benefit From Sipuleucel-T
Lower Baseline PSA Predicts Greater Benefit From Sipuleucel-T Schelhammer PF, Chodak G, Whitmore JB, Sims R, Frohlich MW, Kantoff PW. Lower baseline prostate-specific antigen is associated with a greater
More informationProstate Cancer Management: From Early Chemical Recurrence to HRPC (excluding Immunotherapy).
Thanks to: The Medical Educator Consortium Luis Raez, MD, Florida International University 15th ed. Prostate Cancer Management: From Early Chemical Recurrence to HRPC (excluding Immunotherapy). Mayer Fishman,
More informationX, Y and Z of Prostate Cancer
X, Y and Z of Prostate Cancer Dr Tony Michele Medical Oncologist Prostate cancer Epidemiology Current EUA (et al) guidelines on Advanced Prostate Cancer Current clinical management in specific scenarios
More informationAdvanced Prostate Cancer. Searching for Optimal Therapy Sequence and Assessing Emerging Treatment Options
Advanced Prostate Cancer Searching for Optimal Therapy Sequence and Assessing Emerging Treatment Options Disclaimer This slide deck in its original and unaltered format is for educational purposes and
More informationManagement of mcrpc: Hormonal therapy and treatment sequence for CRPC
Management of mcrpc: Hormonal therapy and treatment sequence for CRPC Professor Bertrand Tombal, MD, PhD Cliniques universitaires Saint-Luc Université catholique de Louvain Brussels, Belgium Credentials
More informationPhilip Kantoff, MD Dana-Farber Cancer Institute
CHEMOTHERAPY FOR MCRPC Philip Kantoff, MD Dana-Farber Cancer Institute Harvard Medical School 1 Disclosure of Financial Relationships With Any Commercial Interest Name Nature of Financial Commercial Interests
More informationUrological Science xxx (2015) 1e5. Contents lists available at ScienceDirect. Urological Science. journal homepage:
Urological Science xxx (2015) 1e5 Contents lists available at ScienceDirect Urological Science journal homepage: www.urol-sci.com Original article The efficacy of abiraterone acetate in treating Taiwanese
More informationRoberto Sabbatini Azienda Ospedaliero Universitaria Policlinico di Modena
Il Trattamento della Malattia CRPC metastatica Terapie Radiometaboliche Roberto Sabbatini Azienda Ospedaliero Universitaria Policlinico di Modena AIOM: Gestione ottimale del Paziente con Carcinoma della
More informationHormone sensitive prostate cancer To add abiraterone or docetaxel? Dr Lisa Pickering
> Hormone sensitive prostate cancer To add abiraterone or docetaxel? Dr Lisa Pickering Disclosures Institutional Research Support/P.I. Employee Consultant Major Stockholder Speakers Bureau Honoraria Scientific
More informationBone-targeted therapies for prostate cancer in Institut Gustave Roussy Villejuif, France
Bone-targeted therapies for prostate cancer in 2012 Pr Karim Fizazi, MD, PhD Institut Gustave Roussy Villejuif, France Disclosure Participation to advisory boards or speaker for: Amgen, Astellas-Medivation,
More informationDr. Tia Higano University of Washington Seattle, USA
AN UPDATE ON THE TREATMENT OF PATIENTS WITH mcrpc WITH RA-223 PLUS AAP Dr. Tia Higano University of Washington Seattle, USA AAP, Abiraterone Acetate and Prednisone/Prednisolone; mcrpc, metastatic Castration-Resistant
More informationInitial Hormone Therapy
Initial Hormone Therapy Alan Horwich Institute of Cancer Research and Royal Marsden Hospital, London, UK Alan.Horwich@icr.ac.uk MANAGEMENT OF PROSTATE CANCER Treatment windows Subclinical Localised PSA
More informationPlease consider the following information on ZYTIGA (abiraterone acetate). ZYTIGA - Compendia Communication - NCCN LATITUDE and STAMPEDE June 2017
Page 1 of 2 Janssen Scientific Affairs, LLC 1125 Trenton-Harbourton Road PO Box 200 Titusville, NJ 08560 800.526.7736 tel 609.730.3138 fax June 08, 2017 Joan McClure 275 Commerce Drive #300 Fort Washington,
More informationThe Role of the Medical Oncologist in the Treatment of Prostate Cancer. Alireza saadat hematologist and oncologist
The Role of the Medical Oncologist in the Treatment of Prostate Cancer Alireza saadat hematologist and oncologist When should you see an oncologist? High risk localized disease Rising PSA after local therapy
More informationCurrent role of chemotherapy in hormone-naïve patients Elena Castro
Current role of chemotherapy in hormone-naïve patients Elena Castro Spanish National Cancer Research Centre Lugano, 17 October 2017 Siegel, Ca Cancer J Clin,2017 Buzzoni, Eur Urol, 2015 -Aprox 15-20% of
More informationPaul F. Schellhammer, MD, FACS Professor Eastern Virginia Medical School Norfolk, Virginia
Paul F. Schellhammer, MD, FACS Professor Eastern Virginia Medical School Norfolk, Virginia 5-year prostate cancer specific survival rates have improved from 67% to 99% between 1974 and 2000 Excellent survival
More informationAmerican Urological Association (AUA) Guideline
1 Approved by the AUA Board of Directors May 2018 Authors disclosure of potential conflicts of interest and author/staff contributions appear at the end of the article. 2018 by the American Urological
More informationOptimizing Outcomes in Advanced Prostate Cancer
Optimizing Outcomes in Advanced Prostate Cancer Module 3: Focus on Recent CRPC Guidelines and Advanced Hormone-Sensitive Disease Sébastien J. Hotte, MD, MSc (HRM), FRCPC Medical Oncologist and Head, Phase
More informationJanuary Abiraterone pre-docetaxel for patients with asymptomatic or minimally symptomatic metastatic castration resistant prostate cancer
LONDON CANCER NEW DRUGS GROUP RAPID REVIEW Abiraterone pre-docetaxel for asymptomatic/minimally symptomatic metastatic castration resistant prostate cancer Abiraterone pre-docetaxel for patients with asymptomatic
More informationA SPECIAL MEETING REVIEW EDITION. Special Reporting on: PLUS Meeting Abstract Summaries. With Expert Commentary by:
August 2013 Volume 11, Issue 8, Supplement 11 A SPECIAL MEETING REVIEW EDITION Highlights in Advanced Prostate Cancer From the 2013 American Urological Association Annual Meeting and the 2013 American
More informationProstate Cancer: Vision of the Future By: H.R.Jalalian
1 H. R. Jalalian Hematologist&Oncologist Baqiyatallah University of Medical Sciences 2 State of the art: vision on the future Diagnosis Surgery Radiotherapy Medical Oncology 3 Early Detection PSA sensitivity
More informationModern Screening and Treatment of Advanced Prostate Cancer John Tuckey
Modern Screening and Treatment of Advanced Prostate Cancer John Tuckey Commonest male cancer - 2939 per year Third male cancer death 670 per year More die with it than of it but More people die of prostate
More informationmcrpc in 2016 How to decide the optimal treatment? N. Mottet
mcrpc in 2016 How to decide the optimal treatment? N. Mottet Disclosures Conflict of interest Chairman EAU PCa guidelines..... Therefore I'm 100% biased Castrate-resistant prostate cancer (CRPC) Definition
More informationEarly Chemotherapy for Metastatic Prostate Cancer
Early Chemotherapy for Metastatic Prostate Cancer Daniel P. Petrylak, MD Professor of Medicine and Urology Smilow Cancer Center Yale University Medical Center Disclosure Consultant: Sanofi Aventis, Celgene,
More informationHave we optimized the use of Androgen Receptor pathway targeted drugs in Castrate-Resistant Prostate Cancer?
Have we optimized the use of Androgen Receptor pathway targeted drugs in Castrate-Resistant Prostate Cancer? Karim Fizazi, MD, PhD Institut Gustave Roussy Villejuif, France Disclosure Participation to
More informationInitial Hormone Therapy
Initial Hormone Therapy Alan Horwich Institute of Cancer Research and Royal Marsden Hospital, London, UK Alan.Horwich@icr.ac.uk MANAGEMENT OF PROSTATE CANCER Treatment windows Subclinical Localised PSA
More informationEvolution of Chemotherapy for. Cancer
Evolution of Chemotherapy for Hormone Refractory Prostate t Cancer Ian F Tannock MD, PhD Daniel E Bergsagel Professor of Medical Oncology Princess Margaret Hospital and University of Toronto In 1985, two
More informationConvegno Nazionale AIOM Giovani 2016: News in Oncology. Daniele Alesini. Istituto Nazionale dei Tumori Regina Elena
Convegno Nazionale AIOM Giovani 2016: News in Oncology Daniele Alesini Istituto Nazionale dei Tumori Regina Elena Something Old Something New Something Borrowed Something Blue DOCETAXEL: BACK AND FORTH
More informationSequencing treatment for metastatic prostate cancer
11 Sequencing treatment for metastatic prostate cancer SOPHIE MERRICK, STYLIANI GERMANOU, ROGER KIRBY AND SIMON CHOWDHURY In the past 10 years there have been significant advances in the understanding
More informationIsotopes and Palliative Radiotherapy for bone metastases
Isotopes and Palliative Radiotherapy for bone metastases Rationale for Bone-seeking Isotope Therapies in Prostate Cancer > 90% of patients with advanced prostate cancer have bone metastases which can be
More informationChemohormonal Therapy For Prostate Cancer. What is old, is new again!
Chemohormonal Therapy For Prostate Cancer What is old, is new again! Mount Tremblant January 20, 2017 Kala S. Sridhar MD, MSc, FRCPC Medical Oncologist, Princess Margaret Hospital Head, GU Medical Oncology
More informationACTUALIZACIONES EN TRATAMIENTOS DIRIGIDOS AL HUESO. COMBINACIÓN CON OTRAS ESTRATEGIAS TERAPÉUTICAS.
ACTUALIZACIONES EN TRATAMIENTOS DIRIGIDOS AL HUESO. COMBINACIÓN CON OTRAS ESTRATEGIAS TERAPÉUTICAS. ÁLVARO PINTO Servicio de Oncología Médica Hospital Universitario La Paz IdiPAZ, Madrid INTRODUCTION High
More informationUpdates in Prostate Cancer Treatment 2018
Updates in Prostate Cancer Treatment 2018 Mountain States Cancer Conference Elaine T. Lam, MD November 3, 2018 Learning Objectives Understand the difference between hormone sensitive and castration resistant
More informationCancer de la prostate métastatique: prise en charge précoce
Cancer de la prostate métastatique: prise en charge précoce Stéphane Oudard, MD, PhD Georges Pompidou Hospital, Oncology Department, Paris, France stephane.oudard@egp.aphp.fr SAGB.CAB.14.08.0382c 3/02/2016
More informationA Forward Look at Options for. In Prostate Cancer
A Forward Look at Options for Prostate Cancer Charles J Ryan, MD Associate Professor of Medicine Helen Diller Family Comprehensive Cancer Center University of California, San Francisco UC 1 SF UC SF Castration
More informationIsotopes and Palliative Radiotherapy for bone metastases
Isotopes and Palliative Radiotherapy for bone metastases Rationale for Bone-seeking Isotope Therapies in Prostate Cancer > 90% of patients with advanced prostate cancer have bone metastases which can be
More informationPresent and Future Perspectives in Treatment of mcrpc Patients
Present and Future Perspectives in Treatment of mcrpc Patients Pr Alexandre de la Taille CHU Mondor, Créteil INSERMU955Eq07 adelataille@hotmail.com Disclosures Astellas, Takeda, Janssen, Bouchara Recordati,
More informationMichiel H.F. Poorthuis*, Robin W.M. Vernooij*, R. Jeroen A. van Moorselaar and Theo M. de Reijke
First-line non-cytotoxic therapy in chemotherapynaive patients with metastatic castration-resistant prostate cancer: a systematic review of 10 randomised clinical trials Michiel H.F. Poorthuis*, Robin
More informationPrincipal Investigator. General Information. Conflict of Interest Published on The YODA Project (http://yoda.yale.edu)
Principal Investigator First Name: Antonio Last Name: Finelli Degree: MD, MSc, FRCSC Primary Affiliation: Princess Margaret Cancer Centre E-mail: antonio.finelli@uhn.ca Phone number: 416-946-4501 x2851
More informationChallenging Cases. With Q&A Panel
Challenging Cases With Q&A Panel Case Studies Index Patient #1 Jeffrey Wieder, MD Case # 1 72 year old healthy male with mild HTN Early 2011: Preop bone scan and pelvic CT = no mets Radical prostatectomy
More informationPrognostic Model Predicting Metastatic Castration-Resistant Prostate Cancer Survival in Men Treated With Second-Line Chemotherapy
DOI:10.1093/jnci/djt280 Advance Access publication October 17, 2013 The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
More informationAdvances in Chemotherapy for Castration Resistant Prostate Cancer
Advances in Chemotherapy for Castration Resistant Prostate Cancer Daniel P. Petrylak, MD Director, Genitourinary Oncology Co Director, Signal Transduction Program Yale Comprehensive Cancer Center Sequencing
More informationMÉTASTASES OSSEUSES ET RADIUM 223
MÉTASTASES OSSEUSES ET RADIUM 223 Marie-Laure Amram Service d oncologie Hôpitaux Universitaires de Genève Forome du 21.05.2015 Radium-22:3:mécanisme d action Mécanisme d action Mécanisme d action Radium-223
More informationmcrpc 2014 TRA EVOLUZIONE E RIVOLUZIONE: COME ORIENTARSI NEL LABIRINTO DELLE TERAPIE
mcrpc 2014 TRA EVOLUZIONE E RIVOLUZIONE: COME ORIENTARSI NEL LABIRINTO DELLE TERAPIE IL CARCINOMA PROSTATICO, UNA MALATTIA ETEROGENEA? RAZIONALE E RISULTATI DEL TRATTAMENTO CHEMIOTERAPICO ASSOCIATO ALL
More informationPOSITIVE CHMP OPINION FOR XTANDI (ENZALUTAMIDE) IN ADVANCED PROSTATE CANCER 1
POSITIVE CHMP OPINION FOR XTANDI (ENZALUTAMIDE) IN ADVANCED PROSTATE CANCER 1 Enzalutamide recommended for approval in the European Union (EU) for the treatment of adult men with metastatic castration-resistant
More informationNuevas perspectivas en el cáncer de próstata hormono-sensible metastásico Tratamiento actual del cáncer de próstata. Situación de Enzalutamida
Nuevas perspectivas en el cáncer de próstata hormono-sensible metastásico Tratamiento actual del cáncer de próstata. Situación de Enzalutamida Dr Pablo Maroto Hospital Sant Pau Dr Pablo Maroto Hospital
More information