HPV Summit: Wisconsin
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1 HPV Summit: Wisconsin Raj Naik, MD Department of Pediatrics Childhood Immunization Champion Gundersen Health System
2 Objectives Learn how to counsel vaccine-hesitant families using the CASE-based approach Demonstrate the ability to use the CASE-based approach to dispel the ten most common HPV vaccine concerns
3 Communication Style Matters Multiple studies have demonstrated that health care provider recommendation and attitude regarding childhood vaccines matters Discuss the vaccines as part of the routine not as an a optional activity Focus on cancer prevention Present the discussion with a positive attitude If there is hesitancy, try to set the table for a discussion
4 CASE *A new model for talking to parents *A mnemonic to organize a rapid, useful response *Draws from Aristotelian teaching on rhetoric *Created by Alison Singer, MD -President, Autism Science Foundation -As taught by Dr. Robert Jacobson, MD Mayo Clinic
5 The CASE Acronym Corroborate About Me Science Explain/Advise
6 Corroborate: Acknowledge the parents concern and find some point on which you can agree; set the tone for a respectful, successful talk About Me: Describe what you have done to build your knowledge base and expertise Science: Relate what the science says Explain/Advise: The CASE Approach Explain your advice to patient, based on the science
7 Corroborate Acknowledge the parents concern and find some point on which you can agree; set the tone for a respectful, successful talk What is your main concern? Then: Don t permit a vague refusal Make the parent get specific That's a valid concern When I heard that, I sought out answers myself We both want your child to be free of illness and injury We both want to avoid unnecessary medications and their side effects
8 About Me: Describe what you have done to build your knowledge base and expertise I m committed to your child s health, and I ve dedicated my career to that work I ve been studying medicine and pediatrics now for X years One of the areas where I read a great deal is about infections, immunity, and vaccination Vaccinations represent a major part of my professional effort as your child s pediatrician
9 Science Science: Relate what the science says Vaccines are better studied than any other medicine I prescribe or test I order Each vaccine is safer than any medicine I prescribe Vaccines are not fool proof but they are the most effective means to prevent certain injuries and illnesses The decision what to give when is based on the vaccine s effectiveness, safety, and specific need for the child at that particular age
10 Explain/Advise Explain/Advise: Explain your advice to patient, based on the science That s why I am recommending this vaccine If this were my child, I would be vaccinating her today I got this vaccine I made sure my children got these vaccines That s why if I were you, I would be getting these vaccines for your child
11 C-A-S-E Practice Scenarios
12 Example #1 Parental Concern: HPV Vaccine is too new
13 HPV Vaccine Myth HPV is too new Licensed in 2006 Pre-licensure studies for several years prior >20,000 study participants 33 countries >187 million doses in >130 countries Post-licensure surveillance (passive and active)
14 Example #2 Parental Concern: We are giving too many shots
15 Immune Overload Theory Addressing Parents Concerns: Do Multiple Vaccines Overwhelm or Weaken the Infant s Immune System? Offit PA, Quarles J et al. PEDIATRICS Vol. 109 No. 1 January 2002, pp Studies on diversity of antigen receptors in the immune system reveal the ability to respond to extremely large numbers of antigens Theoretically 10 9 to different antibody specificities Limited by the number of circulating B cells How many vaccines could a child respond to at one time considering circulating B-cells, antibody production, receptors, and antigenic load of vaccines? 10,000 + vaccines
16 Immune Overload Theory: (Offit et al)
17 Example #3 Parental concern: The aluminum in HPV vaccine is toxic
18 Vaccine Preservatives and Adjuvants Preservatives used in multi-dose vaccine vials to prevent bacterial contamination or to help present the antigens to the immune system (adjuvants) Aluminum is used as an adjuvant in a number of vaccines Source for information on aluminum:
19 Vaccine Preservatives and Adjuvants Aluminum is the third most abundant element making up almost 9 percent of the earth's crust. Aluminum is found in plants, soil, water and air. Aluminum is used extensively and ingested: Aluminum is found in numerous foods and beverages including fruits and vegetables, beer and wine, seasonings, flour, cereals, nuts, dairy products, baby formulas, and honey. Aluminum is found in health products including antacids, buffered aspirin, antiperspirants and some vaccines. Typically, adults ingest 7 to 9 milligrams of aluminum per day.
20 Vaccine Preservatives and Adjuvants Vaccines containing adjuvants are tested extensively in clinical trials before being licensed. Aluminum salts and a detoxified bacterial component called monophosphoryl lipid A are the only materials that can be used as adjuvants in the United States. While infants receive about 4.4 milligrams of aluminum in the first six months of life from vaccines, they receive more than that in their diet.
21 Example #4 Parental Concern: It s too early to give HPV vaccine
22 HPV Vaccine Myth Immune response is more robust earlier in adolescence The vaccine is preventative only and will not work to treat those who are already infected Protection has been long-lasting (>10 years) We will learn about the need for a booster from active surveillance and post-licensure studies
23 Example #5 Parental Concern: Giving HPV vaccine to preteens at age years will result in teens having more sex
24 HPV Vaccine Myth Giving HPV vaccine at an early age will lead to more promiscuous behavior. False!!!
25 Example #6 Parental Concern: HPV vaccine causes Infertility MS or other neurological disease Cancer Death miscellaneous
26 HPV Vaccine Safety Pre-licensure studies >20,000 Passive surveillance (VAERS) Active surveillance (VSD) 60,000
27 HPV Vaccine Safety Fainting and local injection site pain Fainting preventable with lying down for 15 min after injection No significant difference in death, 200 categories of illness, ER visits or hospitalizations after receipt of HPV vaccine compared to baseline population
28 Example #7 Parental Concern: HPV vaccine can cause HPV or make pre-existing disease worse
29 Example #8 Parental Concern: Boys/men do not get cervical cancer so they should not get the vaccine
30 New Cancers Caused by HPV per Year Vagina n=600 3% Oropharynx n=1,800 10% United States Vulva n=2,200 13% Anus n=2,600 15% Cervix n=10,400 59% Penis n=700 8% Anus n=1,400 15% Oropharynx n=7,200 77% Women (n = 17,600) Men (n = 9,300) CDC, United States Cancer Statistics (USCS),
31 Example #9 Parental concern: Isn t it better to get immunity naturally?
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33 HPV Infection Most females and males will be infected with at least one type of mucosal HPV at some point in their lives Most people will never know that they have been infected A majority clear infection, but there is a significant percentage of people who don t clear infection and end up with clinical disease Jemal A et al. J Natl Cancer Inst 2013;105:
34 Without vaccination, annual burden of genital HPV-related disease in U.S. females: 4,000 cervical cancer deaths 10,846 new cases of cervical cancer 330,000 new cases of HSIL: CIN2/3 (high grade cervical dysplasia) 1 million new cases of genital warts 1.4 million new cases of LSIL: CIN1 (low grade cervical dysplasia) 3 million cases and $7 billion American Cancer Society. 2008; Schiffman Arch Pathol Lab Med. 2003; Koshiol Sex Transm Dis. 2004; Insinga, Pharmacoeconomics, 2005
35 Example #10 Parental Concern: I heard HPV vaccine is not that effective
36 HPV Vaccine Efficacy Immunogenicity - over 99% of girls studied developed antibodies after vaccination 4vHPV Efficacy - Clinical trials showed close to 100% protection against pre-cancers and genital warts Since 2006, >60% reduction in HPV infections among teen girls in the US
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39 HPV Vaccine Counseling: How to get to Yes What you do and say as a HCP matters! The more you know about HPV disease, HPV vaccine, and HPV vaccine myths, the easier it will be for you to effectively counsel your patients. Use the CASE-based approach as a tool to help you counsel vaccine-hesitant families.
40 HPV VACCINE IS CANCER PREVENTION And YOU are the key! #WeCanStopHPV
41 Reserve Slides
42 Another Approach to Counseling The Vaccine-Hesitant Parent ScEd3M
43 Billing & Coding H:\2016 CME\Vaccine Counseling Coding.pdf
44 2016 HPV Projects Centralized Electronic Alerts and Reminders >1 year since initiation
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50 *HPV 9 (now the standard) is made using the same VLP technology
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52 Efficacy of 9vHPV Vaccine 96% efficacy against infection with the 5 new HPV types 96.7% efficacy for prevention of female cancers or precancers Antibody titers were non-inferior for the 4 original types >99% sero-converted to all nine HPV types Antibody titers were significantly higher in adolescents age 9 to 15 than for females age 16 to 26
53 Updated ACIP Recommendations Age Routine vaccination at age 11 or 12 years* Vaccination recommended through age 26 for females and males not previously vaccinated Formulation by gender (assuming availability) 9vHPV 4vHPV 2vHPV Females Males *vaccination series can be started at 9 years of age MMWR 2015;64:
54 Updated ACIP Recommendations: Interchangeability If vaccination providers do not know, or do not have available the HPV vaccine product previously administered, or are in settings transitioning to 9vHPV: For protection against HPV 16 and 18, Females: Any HPV vaccine product may be used to continue or complete the series Males: 4vHPV or 9vHPV may be used to continue or complete the series MMWR 2015;64:
55 ACIP Recommendations: Timing of the Series 2vHPV, 4vHPV and 9vHPV are each administered in a 3-dose schedule Interval between doses 1 2: ~6 weeks (1-2 months) Interval between doses 1 3: 6 months Routine dosing intervals are recommended If the vaccine schedule is interrupted, the series does not need to be restarted MMWR 2015;64:
56 GHS HPV Vaccine Data How are we doing at GHS?
57 Gundersen Health System: HPV Rates and NIS Benchmark Data GHS Data Patient Data Extraction Grand Total Female Patients dose doses doses Male Patients dose doses doses Grand Total NIS Benchmark Data Females 1 dose 51.1 (±4.1) 56.6 (±3.9) 61.0 (±4.3) 64.4 (±4.1) 66.5 (±4.4) 60.0 (±1.9) 2 doses 40.1 (±4.0) 46.4 (±4.0) 51.6 (±4.3) 55.7 (±4.2) 57.6 (±4.7) 50.3 (±1.9) 3 doses 26.2 (±3.6) 35.9 (±3.9) 41.2 (±4.2) 43.8 (±4.1) 51.0 (±4.7) 39.7 (±1.9) Males 1 dose 38.9 (±4.2) 42.6 (±4.0) 45.7 (±4.1) 40.0 (±4.0) 41.8 (±4.1) 41.7 (±1.8) 2 doses 27.1 (±3.9) 30.9 (±3.8) 35.8 (±4.1) 31.2 (±3.8) 32.6 (±4.0) 31.4 (±1.7) 3 doses 16.2 (±3.3) 20.9 (±3.5) 24.9 (±4.0) 22.9 (±3.5) 23.3 (±3.7) 21.6 (±1.6)
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59 How To Improve HPV Vaccination Rates Health Care Provider education and training Public education Centralized alerts and reminders Scheduling of subsequent doses with 1 st dose administration Elimination of missed opportunities Using less traditional sites for delivery of vaccine (non-clinic based)
60 How To Improve HPV Vaccination Rates Health Care Provider education and training Public education Centralized alerts and reminders Scheduling of subsequent doses with 1 st dose administration Elimination of missed opportunities Using less traditional sites for delivery of vaccine (non-clinic based)
61 How To Improve HPV Vaccination Rates Health Care Provider education and training Public education Centralized alerts and reminders Scheduling of subsequent doses with 1 st dose administration Elimination of missed opportunities Check Health Maintenance at every visit Use acute care visits as an opportunity to immunize Using less traditional sites for delivery of vaccine (non-clinic based)
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