Melanoma: From Chemotherapy to Targeted Therapy and Immunotherapy. What every patient needs to know. James Larkin

Size: px
Start display at page:

Download "Melanoma: From Chemotherapy to Targeted Therapy and Immunotherapy. What every patient needs to know. James Larkin"

Transcription

1 Melanoma: From Chemotherapy to Targeted Therapy and Immunotherapy What every patient needs to know James Larkin

2 Melanoma Therapy Surgery 1846 Cytotoxic Chemotherapy 1946 Checkpoint Inhibitors Ipilimumab 2011 Nivolumab 2014 Pembrolizumab 2014 Radiation Therapy 1901 Cytokines Interferon-α 1995 Interleukin Targeted Therapies Vemurafenib 2011 Trametinib 2013 Dabrafenib 2013 Cobimetinib 2015

3 Melanoma Therapy Surgery 1846 Cytotoxic Chemotherapy 1946 Checkpoint Inhibitors Ipilimumab 2011 Nivolumab 2014 Pembrolizumab 2014 Radiation Therapy 1901 Cytokines Interferon-α 1995 Interleukin Targeted Therapies Vemurafenib 2011 Trametinib 2013 Dabrafenib 2013 Cobimetinib 2015

4 Historical survival of stage 4 melanoma: median 6-9 months 5- year survival Skin, LNs 25% Lung 15% Liver 10% 5- year survival LDH 25 vs 10% normal vs high Balch JCO 2009

5 Targeted Therapies

6 NRAS RTK e.g. KIT RAF BRAF V600E MEK ERK Abnormal Cellular Cellular Proliferation KIT ~ 2% BRAF ~ 40% NRAS ~ 20% GNAQ ~ 2% Curtin NEJM 2005; Curtin JCO 2006

7 The story starts here

8 The story starts here Davies Nature 2002

9 and continues here Chapman NEJM 2011

10 BRIM-3: Tumour shrinkage Chapman NEJM 2011

11 More about chemotherapy: CM 037 Larkin JCO in press

12 More about chemotherapy: CM 037 Larkin JCO in press

13 BRIM-3: Progression free survival Median PFS 5.3 vs 1.6 months Chapman NEJM 2011

14 BRAFi + MEKi vs BRAFi vemurafenib + cobimetinib vs vemurafenib Larkin NEJM 2014

15 BRAFi + MEKi vs BRAFi: 3 RCTs Trial Dabrafenib + trametinib vs vemurafenib 1 Dabrafenib + trametinib vs dabrafenib 2 Vemurafenib + cobimetinib vs vemurafenib 3 Progression Free Survival medians 11.4 vs 7.3 mos HR 0.56, p< vs 8.8 mos HR 0.75, p= vs 6.2 mos HR 0.51, p< Robert NEJM 2015 Long NEJM 2014 Larkin NEJM 2014

16 17 year old with advanced melanoma

17 17 year old with advanced melanoma

18 Day 9 BRAF inhibitor therapy

19 Day 9 BRAF inhibitor therapy

20 NRAS RTK e.g. KIT RAF BRAF V600E MEK ERK Abnormal Cellular Cellular Proliferation KIT ~ 2% BRAF ~ 40% NRAS ~ 20% GNAQ ~ 2% Curtin NEJM 2005; Curtin JCO 2006

21 Challenges for Targeted Therapy

22 Challenges for Targeted Therapy RESISTANCE TO TREATMENT

23 Checkpoint Inhibitors

24 Interferon Immune stimulation +++ Interleukin 2

25 Interferon Immune stimulation +++ Interleukin 2 CTLA Immune checkpoint inhibitors PD1

26 Mellman Nature 2012

27 Proportion Alive 5-year OS analysis DTIC +/- ipilimumab DTIC + 10 mg/kg Ipi Censored DTIC + Placebo Censored Months Treatment group Median OS, months Overall survival rate, % 1-year 2-year 3-year 4-year 5-year Ipi + DTIC % 28.9% 21.3% 19.1% 18.2% Plac + DTIC % 17.8% 12.1% 9.7% 8.8% PLATEAU

28 The Guardian February 2016: The closest thing yet to a cure for terminal cancer?

29 CA : Study Design CA : Study Design Randomized, double-blind, phase III study to compare NIVO+IPI or NIVO alone to IPI alone* Stratify by: N=314 NIVO 1 mg/kg + IPI 3 mg/kg Q3W for 4 doses then NIVO 3 mg/kg Q2W Unresectable or Metatastic Melanoma Previously untreated 945 patients Randomize 1:1:1 BRAF mutation status AJCC M stage Tumor PD-L1 expression <5% vs 5%* N=316 NIVO 3 mg/kg Q2W + IPI-matched placebo Treat until progression or unacceptable toxicity Co- Primary endpoints: PFS and OS vs IPI Secondary endpoints: ORR, NIVO vs NIVO+IPI (OS and PFS)*, Safety N=315 IPI 3 mg/kg Q3W for 4 doses + NIVO-matched placebo Database lock: Sept 13, 2016 (median follow-up ~30 months in both NIVO-containing arms) *The study was not powered for a comparison between NIVO and NIVO+IPI Larkin AACR 2017

30 Progression-free Percentage Survival of PFS (%) Updated Progression-Free Survival 100 NIVO+IPI (N=314) NIVO (N=316) IPI (N=315) 90 Median PFS, months (95% CI) 11.7 ( ) 6.9 ( ) 2.9 ( ) 80 HR (95% CI) vs. IPI 0.42 ( ) 0.54 ( ) HR (95% CI) vs. NIVO 0.76 ( ) % 43% 43% 30 37% 20 NIVO+IPI 10 NIVO 18% IPI 12% Months Number of patients at risk: NIVO+ IPI NIVO IPI Database lock: Sept 13, 2016

31 Updated Response To Treatment NIVO+IPI (N=314) NIVO (N=316) IPI (N=315) ORR, % (95% CI)* 58.9 ( ) 44.6 ( ) 19.0 ( ) Best overall response % Complete response Partial response Stable disease Progressive disease Unknown Median duration of response, months (95% CI) NR (NR NR) 31.1 (31.1 NR) 18.2 (8.3 NR)

32 Overall Percentage Survival of PFS (%) Overall Survival NIVO+IPI (N=314) NIVO (N=316) IPI (N=315) Median OS, months (95% CI) NR NR (29.1 NR) 20.0 ( ) % HR (98% CI) vs. IPI 0.55 ( ) 0.63 ( ) -- HR (95% CI) vs. NIVO 0.88 ( ) % 67% 64% 59% 45% NIVO+IPI NIVO IPI Months Number of patients at risk: NIVO+IPI NIVO IPI Database lock: Sept 13, 2016

33 Subsequent Therapies: All Randomized Patients NIVO+IPI (N=314) NIVO (N=316) IPI (N=315) Any subsequent therapy, n (%)* 129 (41) 169 (54) 225 (71) Systemic therapy 100 (32) 140 (44) 196 (62) Anti-PD-1 agents 30 (10) 32 (10) 132 (42) Anti-CTLA-4 19 (6) 83 (26) 12 (4) BRAF inhibitors 40 (13) 57 (18) 68 (22) MEK/NRAS Inhibitors 30 (10) 38 (12) 39 (12) Investigational agents** 8 (3) 6 (2) 15 (5) Median time to subsequent systemic therapy, mo (95% CI) 2 year % of pts free of subsequent therapies NR (NR NR) 26.8 (18.0 NR) 8.5 ( )

34 PFS and OS Subgroup Analyses (All Randomized Patients) Descriptive comparison between NIVO+IPI and NIVO Patients Unstratified Hazard Ratio Unstratified Hazard Ratio (95% CI) Subgroup NIVO+IPI NIVO PFS OS PFS OS Overall <65 years years BRAF Mutant BRAF Wild-type ECOG PS = ECOG PS = M0/M1a/M1b M1c LDH ULN LDH > ULN LDH > 2 x ULN PD-L1 5% PD-L1 <5% NIVO+IPI NIVO NIVO+IPI NIVO 2

35 OS (%) OS (%) OS in Patients with Wild-type BRAF and BRAF Mutations BRAF Wild-type BRAF Mutant NIVO+IPI NIVO IPI NIVO+IPI NIVO IPI 100 Median, mo (95% CI) NR (27.6 NA) NR (25.8 NR) 18.5 ( ) 100 Median, mo (95% CI) NR NR (26.4 NR) 24.6 ( ) HR (95% CI) vs NIVO 0.97 ( ) 61% 57% HR (95% CI) vs NIVO 0.71 ( ) 71% 62% 51% % NIVO+IPI NIVO IPI Months Number of patients at risk: NIVO+IPI NIVO+IPI NIVO IPI Months Number of patients at risk: NIVO+IPI NIVO NIVO IPI IPI

36 OS (%) OS (%) OS by Tumor PD-L1 Expression, 5% Cutoff Tumor PD-L1 Expression Level <5% Tumor PD-L1 Expression Level 5% Median OS, mo (95% CI) HR (95% CI) vs NIVO NIVO+IPI NIVO IPI NR (31.8 NR) 0.84 ( ) NR (23.1 NR) 18.5 ( ) Median OS, mo (95% CI) HR (95% CI) vs NIVO NIVO+IPI NIVO IPI NR 1.05 ( ) NR 28.9 (18.1 NR) % % 55% % 54% 30 41% NIVO+IPI NIVO IPI Months Number of patients at risk: NIVO+IPI NIVO IPI Months Number of patients at risk: NIVO+IPI NIVO IPI

37 Response to Treatment by Tumor PD-L1 Expression NIVO+IPI NIVO IPI PD-L1 ( 5%) PD-L1 (<5%) ORR, % (95% CI) Median Duration of Response (months) ORR, % (95% CI) Median Duration of Response (months) 73.5 ( ) 58.8 ( ) 21.3 ( ) NR NR NR 56.2 ( ) 42.3 ( ) 17.8 ( ) NR NR 18.2

38 Safety Summary Updated safety information, with an additional 19 months of follow-up, was consistent with the initial report (Larkin et al. NEJM 2015;373:23 34) NIVO+IPI (N=313) NIVO (N=313) IPI (N=311) Patients reporting event, % Any Grade Grade 3-4 Any Grade Grade 3-4 Any Grade Grade 3-4 Treatment-related adverse event (AE) Treatment-related AE leading to discontinuation Treatment-related death, n (%) 2 (0.6) a 1 (0.3) b 1 (0.3) b ORR was 70.7% for pts who discontinued NIVO+IPI due to AEs, with median OS not reached a Cardiomyopathy (NIVO+IPI, N=1); Liver necrosis (NIVO+IPI, N=1). Both deaths occurred >100 days after the last treatment. b Neutropenia (NIVO, N=1); colon perforation (IPI, N=1). Most select AEs were managed and resolved within 3-4 weeks (85 100% across organ categories)

39 What information do we need to select patients for targeted and immunotherapies? Therapy schedule Disease tempo Chance of success Patient preference Disease distribution Performance status Need for rapid response Adverse events

40

41 Adjuvant Ipilimumab in Melanoma

42 Summary Advanced melanoma historically regarded as generally untreatable with drugs Targeted therapy a major innovation in cancer therapeutics based on understanding biology Resistance generally inevitable in advanced disease though after less than a year on average Immune checkpoint inhibitors generally well tolerated and active in multiple tumour types Anti-CTLA4 therapy probably curative in a small number of patients with advanced melanoma Lots of work still to do; I hope the last 5 years are just the beginning

43 Acknowledgements Our patients and their families Melanoma Clinical Trials Team, Royal Marsden, led by Sister Kim Edmonds Samra Turajlic and Martin Gore Collaborators in the UK and internationally in industry, academia and advocacy groups

44 Thank you

New paradigms for treating metastatic melanoma

New paradigms for treating metastatic melanoma New paradigms for treating metastatic melanoma Paul B. Chapman, MD Melanoma Clinical Director Melanoma and Immunotherapeutics Service Memorial Sloan Kettering Cancer Center, New York 20 th Century Overall

More information

Medical Treatment for Melanoma Sanjiv S. Agarwala, MD

Medical Treatment for Melanoma Sanjiv S. Agarwala, MD Medical Treatment for Melanoma Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer Center, Bethlehem, PA Disclosures None Overview

More information

Immunotherapy in Unresectable or Metastatic Melanoma: Where Do We Stand? Sanjiv S. Agarwala, MD St. Luke s Cancer Center Bethlehem, Pennsylvania

Immunotherapy in Unresectable or Metastatic Melanoma: Where Do We Stand? Sanjiv S. Agarwala, MD St. Luke s Cancer Center Bethlehem, Pennsylvania Immunotherapy in Unresectable or Metastatic Melanoma: Where Do We Stand? Sanjiv S. Agarwala, MD St. Luke s Cancer Center Bethlehem, Pennsylvania Overview Background Immunotherapy clinical decision questions

More information

III Sessione I risultati clinici

III Sessione I risultati clinici 10,30-13,15 III Sessione I risultati clinici Moderatori: Michele Maio - Valter Torri 10,30-10,45 Melanoma: anti CTLA-4 Vanna Chiarion Sileni Vanna Chiarion Sileni IOV-IRCCS,Padova Vanna.chiarion@ioveneto.it

More information

Update on Targeted Therapy in Melanoma

Update on Targeted Therapy in Melanoma Update on Targeted Therapy in Melanoma Seville June 2013 James Larkin FRCP PhD London UK Overview What are the targets in melanoma? BRAF / KIT / NRAS / GNAQ / MEK DNA / microtubules CTLA4 / PD1 / PDL1

More information

Immunotherapy of Melanoma Sanjiv S. Agarwala, MD

Immunotherapy of Melanoma Sanjiv S. Agarwala, MD Immunotherapy of Melanoma Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer Center, Bethlehem, PA Overview Metastatic Melanoma

More information

Immunotherapy for Renal Cell Carcinoma. James Larkin

Immunotherapy for Renal Cell Carcinoma. James Larkin Immunotherapy for Renal Cell Carcinoma James Larkin Disclosures Institutional research support: BMS, MSD, Novartis, Pfizer Consultancy (all non-remunerated): Eisai, BMS, MSD, GSK, Pfizer, Novartis, Roche/Genentech

More information

Immunotherapies in melanoma: regulatory perspective. Jorge Camarero (AEMPS)

Immunotherapies in melanoma: regulatory perspective. Jorge Camarero (AEMPS) Immunotherapies in melanoma: regulatory perspective Jorge Camarero (AEMPS) Challenges for the approval of anti-cancer immunotherapeutic drugs EMA-CDDF joint meeting, London 4-5 February 2016 disclaimers

More information

Update on Immunotherapy in Advanced Melanoma. Ragini Kudchadkar, MD Assistant Professor Winship Cancer Institute Emory University Sea Island 2017

Update on Immunotherapy in Advanced Melanoma. Ragini Kudchadkar, MD Assistant Professor Winship Cancer Institute Emory University Sea Island 2017 Update on Immunotherapy in Advanced Melanoma Ragini Kudchadkar, MD Assistant Professor Winship Cancer Institute Emory University Sea Island 2017 1 Outline Adjuvant Therapy Combination Immunotherapy Single

More information

Immunotherapy for the Treatment of Melanoma. Marlana Orloff, MD Thomas Jefferson University Hospital

Immunotherapy for the Treatment of Melanoma. Marlana Orloff, MD Thomas Jefferson University Hospital Immunotherapy for the Treatment of Melanoma Marlana Orloff, MD Thomas Jefferson University Hospital Disclosures Immunocore and Castle Biosciences, Consulting Fees I will be discussing non-fda approved

More information

Innovations in Immunotherapy - Melanoma. Systemic Therapies October 27, 2018 Charles L. Bane, MD

Innovations in Immunotherapy - Melanoma. Systemic Therapies October 27, 2018 Charles L. Bane, MD Innovations in Immunotherapy - Melanoma Systemic Therapies October 27, 2018 Charles L. Bane, MD Melanoma Prognosis Survival at 10 years Stage I: 90% Stage II: 60% Stage III: 40% Stage IV: 10% 2 Indications

More information

6/7/16. Melanoma. Updates on immune checkpoint therapies. Molecularly targeted therapies. FDA approval for talimogene laherparepvec (T- VEC)

6/7/16. Melanoma. Updates on immune checkpoint therapies. Molecularly targeted therapies. FDA approval for talimogene laherparepvec (T- VEC) Melanoma John A Thompson MD July 17, 2016 Featuring: Updates on immune checkpoint therapies Molecularly targeted therapies FDA approval for talimogene laherparepvec (T- VEC) 1 Mechanism of ac-on of Ipilimumab

More information

New Therapeutic Approaches to Malignant Melanoma

New Therapeutic Approaches to Malignant Melanoma 2018 Master Class for Oncologists New Therapeutic Approaches to Malignant Melanoma F. Stephen Hodi, M.D. Dana-Farber Cancer Institute, Boston, MA Disclosure I have nothing to disclose. Off Label/Investigational

More information

Immunotherapy for Melanoma. Michael Postow, MD Melanoma and Immunotherapeutics Service Memorial Sloan Kettering Cancer Center

Immunotherapy for Melanoma. Michael Postow, MD Melanoma and Immunotherapeutics Service Memorial Sloan Kettering Cancer Center Immunotherapy for Melanoma Michael Postow, MD Melanoma and Immunotherapeutics Service Memorial Sloan Kettering Cancer Center Conflicts of Interest Bristol-Myers Squibb: -Research support -Participated

More information

Melanoma Clinical Trials and Real World Experience

Melanoma Clinical Trials and Real World Experience Melanoma Clinical Trials and Real World Experience Paul Lorigan University of Manchester Manchester, UK www.christie.nhs.uk/melanoma Melanoma Bridge, Naples 214 New Benchmarks for Phase II Trials OS at

More information

New Systemic Therapies in Advanced Melanoma

New Systemic Therapies in Advanced Melanoma New Systemic Therapies in Advanced Melanoma Sanjay Rao, MD FRCPC Medical Oncologist (BCCA-CSI) Clinical Assistant Professor, UBC Faculty of Medicine SON Fall Update October 22, 2016 Disclosures Equity

More information

Current Trends in Melanoma Theresa Medina, MD UCD Cutaneous Oncology

Current Trends in Melanoma Theresa Medina, MD UCD Cutaneous Oncology Current Trends in Melanoma Theresa Medina, MD UCD Cutaneous Oncology Overview Melanoma incidence and prevention Approach to surgical management of early melanoma Landscape of Advanced Melanoma Therapy

More information

The Current Status of Immune Checkpoint Inhibitors: Arvin Yang, MD PhD Oncology Global Clinical Research Bristol-Myers Squibb

The Current Status of Immune Checkpoint Inhibitors: Arvin Yang, MD PhD Oncology Global Clinical Research Bristol-Myers Squibb The Current Status of Immune Checkpoint Inhibitors: A Global Overview of the Field Arvin Yang, MD PhD Oncology Global Clinical Research Bristol-Myers Squibb Immune Checkpoint Inhibitors Conference, March

More information

Targeted Therapies in Melanoma

Targeted Therapies in Melanoma Mutations and Targets Targeted Therapies in Melanoma ckit NRAS

More information

Best Practices in the Treatment and Management of Metastatic Melanoma. Melanoma

Best Practices in the Treatment and Management of Metastatic Melanoma. Melanoma Best Practices in the Treatment and Management of Metastatic Melanoma Philip Friedlander MD PhD Director of Melanoma Medical Oncology Program Assistant Professor Division of Hematology Oncology Assistant

More information

ASCO 2014: The Future is Here. What I Will Talk About. George W. Sledge MD Stanford University School of Medicine

ASCO 2014: The Future is Here. What I Will Talk About. George W. Sledge MD Stanford University School of Medicine ASCO 214: The Future is Here George W. Sledge MD Stanford University School of Medicine What I Will Talk About Two paths to a Cure Slicing the pie MelMng the snowflake The Past Isn t Dead Improving PaMent

More information

Melanoma: Therapeutic Progress and the Improvements Continue

Melanoma: Therapeutic Progress and the Improvements Continue Melanoma: Therapeutic Progress and the Improvements Continue David W. Ollila, MD Professor of Surgery Jesse and James Millis Professor of Melanoma Research May 20, 2016 Disclosures: NONE Outline 2016 Therapeutic

More information

Melanoma: Immune checkpoints

Melanoma: Immune checkpoints ESMO Preceptorship Programme Immuno-Oncology Siena, July 04-05, 2016 Melanoma: Immune checkpoints Michele Maio Medical Oncology and Immunotherapy-Department of Oncology University Hospital of Siena, Istituto

More information

Unmet Need Mucosal and Uveal Melanoma

Unmet Need Mucosal and Uveal Melanoma Unmet Need Mucosal and Uveal Melanoma Matteo Carlino Crown Princess Mary Cancer Centre Westmead and Blacktown Hospitals Melanoma Institute Australia The University of Sydney. Cutaneous Overall Survival

More information

Terapia Immunomodulante e Target Therapies nel Trattamento del Melanoma Metastatico

Terapia Immunomodulante e Target Therapies nel Trattamento del Melanoma Metastatico Terapia Immunomodulante e Target Therapies nel Trattamento del Melanoma Metastatico Pier Francesco Ferrucci Direttore, Unità di Oncologia Medica del Melanoma Istituto Europeo di Oncologia - Milano Pisa,

More information

Melanoma. Il parere dell esperto. V. Ferraresi. Divisione di Oncologia Medica 1

Melanoma. Il parere dell esperto. V. Ferraresi. Divisione di Oncologia Medica 1 Melanoma Il parere dell esperto V. Ferraresi Divisione di Oncologia Medica 1 MELANOMA and ESMO 2017.what happens? New data and updates ADJUVANT THERAPY with CHECKPOINT INHIBITORS (CA209-238 trial) AND

More information

Black is the New Black or How I learned to stop worrying and love melanoma (with apologies to Dr. Strangelove)

Black is the New Black or How I learned to stop worrying and love melanoma (with apologies to Dr. Strangelove) Black is the New Black or How I learned to stop worrying and love melanoma (with apologies to Dr. Strangelove) Provincial Cancer Care Conference 2018 Ralph P.W. Wong MD FRCPC St Boniface Site Director

More information

Approaches To Treating Advanced Melanoma

Approaches To Treating Advanced Melanoma Approaches To Treating Advanced Melanoma Suraj Venna, MD Medical Director, Melanoma and Cutaneous Oncology Inova Schar Cancer Institute Associate Professor, VCU Fairfax VA Disclosures No relevant disclosures

More information

What we learned from immunotherapy in the past years

What we learned from immunotherapy in the past years What we learned from immunotherapy in the past years Paolo A. Ascierto, MD Unit Melanoma, Cancer Immunotherapy and Innovative Therapies Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Italy Disclosure

More information

Combination Approaches in Melanoma: A Balancing Act

Combination Approaches in Melanoma: A Balancing Act Combination Approaches in Melanoma: A Balancing Act Antoni Ribas, MD, PhD Jonsson Comprehensive Cancer Center University of California Los Angeles Los Angeles, California Advances in the Treatment of Metastatic

More information

Treatment and management of advanced melanoma: Paul B. Chapman, MD Melanoma Clinical Director, Melanoma and Immunotherapeutics Service MSKCC

Treatment and management of advanced melanoma: Paul B. Chapman, MD Melanoma Clinical Director, Melanoma and Immunotherapeutics Service MSKCC Treatment and management of advanced melanoma: 2018 Paul B. Chapman, MD Melanoma Clinical Director, Melanoma and Immunotherapeutics Service MSKCC Disclosure Paul B. Chapman, MD Nothing to disclose. Off

More information

MELANOMA METASTASICO: NUEVAS COMBINACIONES. Dr Ana Arance MD PhD Oncología Médica Hospital Clínic Barcelona

MELANOMA METASTASICO: NUEVAS COMBINACIONES. Dr Ana Arance MD PhD Oncología Médica Hospital Clínic Barcelona MELANOMA METASTASICO: NUEVAS COMBINACIONES Dr Ana Arance MD PhD Oncología Médica Hospital Clínic Barcelona Summary of OS accross clinical trials in patients with metastatic melanoma Ugurel et al. Eur J

More information

CheckMate 012: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer

CheckMate 012: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer CheckMate 12: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer Abstract 31 Hellmann MD, Gettinger SN, Goldman J, Brahmer J, Borghaei H, Chow LQ, Ready NE,

More information

Immunoterapia e melanoma maligno metastatico: siamo partiti da li. Vanna Chiarion Sileni Istituto Oncologico Veneto

Immunoterapia e melanoma maligno metastatico: siamo partiti da li. Vanna Chiarion Sileni Istituto Oncologico Veneto Immunoterapia e melanoma maligno metastatico: siamo partiti da li Vanna Chiarion Sileni Istituto Oncologico Veneto Vanna.chiarion@iov.veneto.it Metastatic Melanoma Available Treatment: 197 217 Zelboraf

More information

PTAC meeting held on 5 & 6 May (minutes for web publishing)

PTAC meeting held on 5 & 6 May (minutes for web publishing) PTAC meeting held on 5 & 6 May 2016 (minutes for web publishing) PTAC minutes are published in accordance with the Terms of Reference for the Pharmacology and Therapeutics Advisory Committee (PTAC) and

More information

Summary... 2 MELANOMA AND OTHER SKIN TUMOURS... 3

Summary... 2 MELANOMA AND OTHER SKIN TUMOURS... 3 ESMO 2016 Congress 7-11 October, 2016 Copenhagen, Denmark Table of Contents Summary... 2 MELANOMA AND OTHER SKIN TUMOURS... 3 Long-term results show adjuvant therapy with ipilimumab improves OS in high

More information

Overall Survival in COLUMBUS: A Phase 3 Trial of Encorafenib (ENCO) Plus Binimetinib (BINI) vs Vemurafenib (VEM) or ENCO in BRAF-Mutant Melanoma

Overall Survival in COLUMBUS: A Phase 3 Trial of Encorafenib (ENCO) Plus Binimetinib (BINI) vs Vemurafenib (VEM) or ENCO in BRAF-Mutant Melanoma Overall Survival in COLUMBUS: A Phase 3 Trial of Encorafenib (ENCO) Plus Binimetinib (BINI) vs Vemurafenib () or ENCO in BRAF-Mutant Melanoma, Paolo A. Ascierto, Helen J. Gogas, Ana Arance, Mario Mandala,

More information

NSCLC: immunotherapy as a first-line treatment. Paolo Bironzo Oncologia Polmonare AOU S. Luigi Gonzaga Orbassano (To)

NSCLC: immunotherapy as a first-line treatment. Paolo Bironzo Oncologia Polmonare AOU S. Luigi Gonzaga Orbassano (To) NSCLC: immunotherapy as a first-line treatment Paolo Bironzo Oncologia Polmonare AOU S. Luigi Gonzaga Orbassano (To) The 800-pound gorilla Platinum-based chemotherapy is the SOC for 1st-line therapy in

More information

ASCO / COLUMBUS ENCORE PRESENTATION June 4, 2018

ASCO / COLUMBUS ENCORE PRESENTATION June 4, 2018 ASCO / COLUMBUS ENCORE PRESENTATION June 4, 2018 SAFE HARBOR STATEMENT Forward-looking statements made in the course of this presentation are made pursuant to the safe harbor provisions of the Private

More information

Immunotherapy for Metastatic Malignant Melanoma. Dr Daniel A Vorobiof Sandton Oncology Centre Johannesburg

Immunotherapy for Metastatic Malignant Melanoma. Dr Daniel A Vorobiof Sandton Oncology Centre Johannesburg Immunotherapy for Metastatic Malignant Melanoma Dr Daniel A Vorobiof Sandton Oncology Centre Johannesburg Survival in Melanoma by Stage Proportion Surviving 1.0 0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 Stage

More information

for patients with ECOG PS 0-1 as indicated in the CheckMate-067 trial. Upon reconsideration of the Initial Recommendation, perc noted PAG s feedback requesting guidance on extrapolating eligibility to

More information

MELANOMA: THE BEST OF THE YEAR Dott.ssa Silvia Quadrini UOC Oncologia ASL Frosinone

MELANOMA: THE BEST OF THE YEAR Dott.ssa Silvia Quadrini UOC Oncologia ASL Frosinone MELANOMA: THE BEST OF THE YEAR 2018 Dott.ssa Silvia Quadrini UOC Oncologia ASL Frosinone The Best of the Year 2018: MELANOMA CHIRURGIA TERAPIA ADIUVANTE TERAPIA PER MALATTIA AVANZATA The Best of the Year

More information

Update on Melanoma Treatment. Tara C Mitchell, MD

Update on Melanoma Treatment. Tara C Mitchell, MD Update on Melanoma Treatment Tara C Mitchell, MD Overview Immune therapy update Targeted therapy update New concepts in treating melanoma What is the immune system? A complex network of protective cells

More information

Immunotherapy Experience in Melanoma Integrating IO into Clinical Practice Sanjiv S. Agarwala, MD

Immunotherapy Experience in Melanoma Integrating IO into Clinical Practice Sanjiv S. Agarwala, MD Immunotherapy Experience in Melanoma Integrating IO into Clinical Practice Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer

More information

BRAF Inhibitors in Metastatic disease. Grant McArthur MB BS PhD Peter MacCallum Cancer Centre Melbourne, Australia

BRAF Inhibitors in Metastatic disease. Grant McArthur MB BS PhD Peter MacCallum Cancer Centre Melbourne, Australia Inhibitors in Metastatic disease Grant McArthur MB BS PhD Peter MacCallum Cancer Centre Melbourne, Australia Disclosures Research Support Pfizer & Cellgene Consultant Provectus Mortality from Melanoma

More information

Immunotherapy in the Adjuvant Setting for Melanoma: What You Need to Know

Immunotherapy in the Adjuvant Setting for Melanoma: What You Need to Know Immunotherapy in the Adjuvant Setting for Melanoma: What You Need to Know Jeffrey Weber, MD, PhD Laura and Isaac Perlmutter Cancer Center NYU Langone Medical Center New York, New York What Is the Current

More information

Overall Survival (OS) Analysis From an Expanded Access Program (EAP) of Nivolumab (NIVO) in Combination with Ipilimumab (IPI) in Patients with Advanced Melanoma (MEL) David Hogg, Paul B. Chapman, 2 Mario

More information

Conversations in Oncology. November Kerry Hotel Pudong, Shanghai China

Conversations in Oncology. November Kerry Hotel Pudong, Shanghai China Conversations in Oncology November 12-13 Kerry Hotel Pudong, Shanghai China Immunotherapy of Lung Cancer Professor Caicun Zhou All materials are for scientific exchanges. Afatinib and nintedanib are not

More information

New Frontiers in Metastatic Melanoma: A Closer Look at the Role of Immunotherapy

New Frontiers in Metastatic Melanoma: A Closer Look at the Role of Immunotherapy New Frontiers in Metastatic Melanoma: A Closer Look at the Role of Immunotherapy Philip Friedlander MD PhD Director of Melanoma Medical Oncology Program Assistant Professor Division of Hematology Oncology

More information

Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr.

Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr. Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr. Diretor de Onco-Hematologia Hospital BP, A Beneficência Portuguesa Non-Small Cell Lung Cancer PD-1/PD-L1 Inhibitors in second-line therapy

More information

Melanoma- Fighting the Dark Side

Melanoma- Fighting the Dark Side Melanoma- Fighting the Dark Side Anna C. Pavlick, BSN, MSc, DO, MBA Professor of Medicine and Dermatology Director, NYU Melanoma Program Director, NYU Clinical Trials Office NYU Perlmutter Cancer Center

More information

Management of Brain Metastases Sanjiv S. Agarwala, MD

Management of Brain Metastases Sanjiv S. Agarwala, MD Management of Brain Metastases Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer Center, Bethlehem, PA, USA Incidence (US):

More information

Immune checkpoint inhibition in melanoma. John Haanen

Immune checkpoint inhibition in melanoma. John Haanen Immune checkpoint inhibition in melanoma John Haanen ESMO Preceptorship Singapore 217 Immune Checkpoint inhibitors Immune checkpoints play an important role in immune tolerance Cancer hijacks many of these

More information

Immunotherapy, an exciting era!!

Immunotherapy, an exciting era!! Immunotherapy, an exciting era!! Yousef Zakharia MD University of Iowa and Holden Comprehensive Cancer Center Alliance Meeting, Chicago November 2016 Presentation Objectives l General approach to immunotherapy

More information

AACR 2018 Investor Meeting

AACR 2018 Investor Meeting AACR 218 Investor Meeting April 16, 218 1 Forward-Looking Information This presentation contains statements about the Company s future plans and prospects that constitute forward-looking statements for

More information

Out of 129 patients with NSCLC treated with Nivolumab in a phase I trial, the OS rate at 5-y was about 16 %, clearly higher than historical rates.

Out of 129 patients with NSCLC treated with Nivolumab in a phase I trial, the OS rate at 5-y was about 16 %, clearly higher than historical rates. 6th Meeting on external quality assessment in molecular pathology, Naples, May 12-13, 2017 Overview of clinical development of checkpoint inhibitors in solid tumors Pr Jaafar BENNOUNA University of Nantes

More information

Il ruolo di PD-L1 (42%) tra la prima e la seconda linea di trattamento

Il ruolo di PD-L1 (42%) tra la prima e la seconda linea di trattamento Il ruolo di PD-L1 (42%) tra la prima e la seconda linea di trattamento Alessia Pochesci Divisione di Oncologia Toracica Istituto Europeo di Oncologia, Milano Tutor: Prof.ssa Silvia Novello Dott.ssa Chiara

More information

presentation session & clinical Keith T. Flaherty, M.D. Abramson Cancer Center of the University of Pennsylvania

presentation session & clinical Keith T. Flaherty, M.D. Abramson Cancer Center of the University of Pennsylvania Melanoma: highlights from the oral presentation session & clinical science symposium at ASCO 2009 Keith T. Flaherty, M.D. Abramson Cancer Center of the University of Pennsylvania Abstracts to be discussed

More information

Histology independent indications in oncology. The BRAF Story. Yibing Yan PhD Roche / Genentech

Histology independent indications in oncology. The BRAF Story. Yibing Yan PhD Roche / Genentech Histology independent indications in oncology The BRAF Story Yibing Yan PhD Roche / Genentech 1 Introduction the discovery Case study in BRAF mutant melanoma heterogeneity within the tumour variability

More information

Biomarkers for immunotherapy. John Haanen MD PhD

Biomarkers for immunotherapy. John Haanen MD PhD Biomarkers for immunotherapy John Haanen MD PhD Clear value of mobilizing endogenous tumor-specific T cell responses 1. TIL therapy J. Haanen, NKI-AVL 1. Checkpoint blockade C. Robert, NEJM 2015 Where

More information

Checkpoint regulators a new class of cancer immunotherapeutics. Dr Oliver Klein Medical Oncologist ONJCC Austin Health

Checkpoint regulators a new class of cancer immunotherapeutics. Dr Oliver Klein Medical Oncologist ONJCC Austin Health Checkpoint regulators a new class of cancer immunotherapeutics Dr Oliver Klein Medical Oncologist ONJCC Austin Health Cancer...Immunology matters Anti-tumour immune response The participants Dendritc cells

More information

Optimizing Immunotherapy New Approaches, Biomarkers, Sequences and Combinations Immunotherapy in the clinic Melanoma

Optimizing Immunotherapy New Approaches, Biomarkers, Sequences and Combinations Immunotherapy in the clinic Melanoma Optimizing Immunotherapy New Approaches, Biomarkers, Sequences and Combinations Immunotherapy in the clinic Melanoma Dr. J.L.Manzano S. Oncología Médica H. Germans Trias i Pujol, ICO-Badalona PRBB Auditorium,

More information

Renal Cell Carcinoma: Systemic Therapy Progress and Promise

Renal Cell Carcinoma: Systemic Therapy Progress and Promise Renal Cell Carcinoma: Systemic Therapy Progress and Promise Michael B. Atkins, M.D. Deputy Director, Lombardi Comprehensive Cancer Ctr Georgetown University Medical Center Everolimus Rini, Campbell, Escudier.

More information

Immunotherapy Treatment Developments in Medical Oncology

Immunotherapy Treatment Developments in Medical Oncology Immunotherapy Treatment Developments in Medical Oncology A/Prof Phillip Parente Director Cancer Services Eastern Health Executive MOGA ATC Medical Oncology RACP www.racpcongress.com.au Summary of The Desired

More information

New treatments in melanoma

New treatments in melanoma New treatments in melanoma Paolo A. Ascierto, MD Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy Meta-analysis of Phase II cooperative group trials in metastatic stage IV melanoma to determine

More information

Array BioPharma Jefferies 2016 Global Healthcare Conference. June 9, 2016

Array BioPharma Jefferies 2016 Global Healthcare Conference. June 9, 2016 Array BioPharma Jefferies 216 Global Healthcare Conference June 9, 216 Safe Harbor Statement 2 Forward-looking statements made in the course of this presentation are made pursuant to the safe harbor provisions

More information

Presentation Number: LBA18_PR. Lecture Time: 09:15-09:27. Speakers: Heinz-Josef J. Lenz (Los Angeles, US) Background

Presentation Number: LBA18_PR. Lecture Time: 09:15-09:27. Speakers: Heinz-Josef J. Lenz (Los Angeles, US) Background LBA18_PR - Durable Clinical Benefit With Nivolumab (NIVO) Plus Low-Dose Ipilimumab (IPI) as First-Line Therapy in Microsatellite Instability-High/Mismatch Repair Deficient (MSI-H/dMMR) Metastatic Colorectal

More information

Melanoma brain mets management

Melanoma brain mets management Melanoma brain mets management Reinhard Dummer, Phil Cheng, Simone Goldinger, Katrin Kerl, Lars French, Joanna Mangana, Lukas Sommer, Ralph Braun, Mitch Levesque Substantially worse survival in patients

More information

LESSONS LEARNT Melanoma Academic Perspective

LESSONS LEARNT Melanoma Academic Perspective LESSONS LEARNT Melanoma Academic Perspective Paolo A. Ascierto, MD Unit Melanoma, Cancer Immunotherapy and Innovative Therapies Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Italy Disclosures

More information

BRAF Gene Variant Testing To Select Melanoma or Glioma Patients for Targeted Therapy

BRAF Gene Variant Testing To Select Melanoma or Glioma Patients for Targeted Therapy BRAF Gene Variant Testing To Select Melanoma or Glioma Patients for Targeted Therapy Policy Number: 2.04.77 Last Review: 12/2018 Origination: 4/2013 Next Review: 12/2019 Policy Blue Cross and Blue Shield

More information

pcodr EXPERT REVIEW COMMITTEE (perc) INITIAL RECOMMENDATION

pcodr EXPERT REVIEW COMMITTEE (perc) INITIAL RECOMMENDATION pcodr EXPERT REVIEW COMMITTEE (perc) INITIAL RECOMMENDATION The CADTH pan-canadian Oncology Drug Review (pcodr) was established by Canada s provincial and territorial M inistries of Health (with the exception

More information

Evolving Treatment Strategies in the Management of Metastatic Melanoma: Novel Therapies for Improved Patient Outcomes. Disclosures

Evolving Treatment Strategies in the Management of Metastatic Melanoma: Novel Therapies for Improved Patient Outcomes. Disclosures Evolving Treatment Strategies in the Management of Metastatic Melanoma: Novel Therapies for Improved Patient Outcomes Fall Managed Care Forum November 11, 2016 Matthew Taylor, M.D. Disclosures Consulting/Advisory

More information

Overview: Immunotherapy in CNS Metastases

Overview: Immunotherapy in CNS Metastases Overview: Immunotherapy in CNS Metastases Manmeet Ahluwalia, MD, FACP Miller Family Endowed Chair in Neuro-Oncology Director Brain Metastasis Research Program Cleveland Clinic Disclosures Consultant- Monteris

More information

Immunoterapia di 1 linea Evidenze e Prospettive Future

Immunoterapia di 1 linea Evidenze e Prospettive Future Immunoterapia di 1 linea Evidenze e Prospettive Future Sara Pilotto Oncologia Medica, Dipart. di Medicina, Università di Verona, A.O.U.I. Verona sara.pilotto@univr.it Negrar, 30 ottobre 2018 Disclosures

More information

NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Single Technology Appraisal (STA) Dabrafenib for treating unresectable, advanced or metastatic

NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Single Technology Appraisal (STA) Dabrafenib for treating unresectable, advanced or metastatic NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Single Technology Appraisal (STA) Dabrafenib for treating unresectable, advanced or metastatic BRAF V600 mutation-positive melanoma mutation-positive melanoma

More information

Kombination von Checkpointinhibitoren beim malignen Melanom

Kombination von Checkpointinhibitoren beim malignen Melanom Kombination von Checkpointinhibitoren beim malignen Melanom Dirk Jäger Medizinische Onkologie Nationales Centrum für Tumorerkrankungen Universitätsklinikum Heidelberg Ipilimumab beim metastasierten Melanom

More information

Normal RAS-RAF (MAPK) pathway signaling

Normal RAS-RAF (MAPK) pathway signaling BRAF-Mutations in Melanomas L. Mazzucchelli Istituto Cantonale di Patologia, Locarno 77. Annual Meeting Swiss Society of Pathology, Lucerne 2011 Sponsored by Roche Pharma Switzerland Melanoma has increased

More information

Immunotherapy for Melanoma. Caroline Robert, MD, PhD Gustave Roussy and Université Paris Sud Villejuif, France

Immunotherapy for Melanoma. Caroline Robert, MD, PhD Gustave Roussy and Université Paris Sud Villejuif, France Immunotherapy for Melanoma Caroline Robert, MD, PhD Gustave Roussy and Université Paris Sud Villejuif, France Overall Survival for Metastatic Melanoma Proportion Alive 1.0 0.8 0.6 0.4 0.2 Survival data

More information

The Really Important Questions Current Immunotherapy Trials are Not Answering

The Really Important Questions Current Immunotherapy Trials are Not Answering The Really Important Questions Current Immunotherapy Trials are Not Answering David McDermott, MD Beth Israel Deaconess Medical Center Dana Farber/Harvard Cancer Center Harvard Medical School PD-1 Pathway

More information

Review of immunotherapy in melanoma

Review of immunotherapy in melanoma Review of immunotherapy in melanoma Surein Arulananda, 1,2,3 Elizabeth Blackley, 1 Jonathan Cebon 1,2,3 1. Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia. 2. Cancer Immunobiology

More information

ADVANCED COLORECTAL CANCER: UNRESECTABLE OR BORDERLINE RESECTABLE (GROUP 1) CHEMOTHERAPY +/- TARGETED AGENTS. Andrés Cervantes. Professor of Medicine

ADVANCED COLORECTAL CANCER: UNRESECTABLE OR BORDERLINE RESECTABLE (GROUP 1) CHEMOTHERAPY +/- TARGETED AGENTS. Andrés Cervantes. Professor of Medicine ADVANCED COLORECTAL CANCER: UNRESECTABLE OR BORDERLINE RESECTABLE (GROUP 1) CHEMOTHERAPY +/- TARGETED AGENTS Andrés Cervantes Professor of Medicine 1995 One option Advances in the treatment of mcrc 2000

More information

Índice. Melanoma Cáncer de Pulmón Otros tumores

Índice. Melanoma Cáncer de Pulmón Otros tumores Índice Melanoma Cáncer de Pulmón Otros tumores Carcinoma de Vejiga Carcinoma de Células Renales Carcinoma de Cabeza y Cuello Carcinomas del tubo digestivo Cáncer de Mama MELANOMA CIRUGÍA CIRUGÍA + INFa

More information

Beyond BRAFi/MEKi: Combination and Sequencing Approaches for in Patients with Metastatic BRAF V600 Mutant Melanoma:

Beyond BRAFi/MEKi: Combination and Sequencing Approaches for in Patients with Metastatic BRAF V600 Mutant Melanoma: Beyond BRAFi/MEKi: Combination and Sequencing Approaches for in Patients with Metastatic BRAF V600 Mutant Melanoma: Michael B. Atkins, M.D. Deputy Director Georgetown-Lombardi Comprehensive Cancer Center

More information

Appendices. Appendix A Search terms

Appendices. Appendix A Search terms Appendices Appendix A Search terms Database Search terms Medline 1. Ipilimumab; 2. MDX-010; 3. MDX-101; 4. Yervoy; 5. BMS-734016; 6. Nivolumab; 7. ONO-4538; 8. BMS-936558; 9. MDX-1106; 10. Opdivo; 11.

More information

MEETING SUMMARY ESMO 2018, Munich, Germany. Dr. Jenny Seligmann University of Leeds, UK HIGHLIGHTS ON COLORECTAL CANCER

MEETING SUMMARY ESMO 2018, Munich, Germany. Dr. Jenny Seligmann University of Leeds, UK HIGHLIGHTS ON COLORECTAL CANCER MEETING SUMMARY ESMO 2018, Munich, Germany Dr. Jenny Seligmann University of Leeds, UK HIGHLIGHTS ON COLORECTAL CANCER DISCLAIMER Please note: The views expressed within this presentation are the personal

More information

Debate 1 Are treatments for small cell lung cancer getting better? No:

Debate 1 Are treatments for small cell lung cancer getting better? No: Debate 1 Are treatments for small cell lung cancer getting better? No: Taofeek Owonikoko, MD, PhD Associate Professor Department of Hematology & Medical Oncology Winship Cancer Institute of Emory University

More information

Breakthrough and Landscape of Acral and Mucosal Melanomas. Jun Guo. M.D., Ph.D Peking University Cancer Hospital & Institute

Breakthrough and Landscape of Acral and Mucosal Melanomas. Jun Guo. M.D., Ph.D Peking University Cancer Hospital & Institute Breakthrough and Landscape of Acral and Mucosal Melanomas Jun Guo. M.D., Ph.D Peking University Cancer Hospital & Institute Current status of advanced melanoma Current status of advanced MM Targeted therapy

More information

Malignant Melanoma, what s new? Dr Daniel A Vorobiof Sandton Oncology Centre Johannesburg

Malignant Melanoma, what s new? Dr Daniel A Vorobiof Sandton Oncology Centre Johannesburg Malignant Melanoma, what s new? Dr Daniel A Vorobiof Sandton Oncology Centre Johannesburg Melanoma Epidemiology: Incidence and Mortality Estimated 2012 Global Incidence and Mortality by WHO Region (all

More information

Melanoma Update Lynn Schuchter, MD Abramson Cancer Center University of Pennsylvania

Melanoma Update Lynn Schuchter, MD Abramson Cancer Center University of Pennsylvania Melanoma Update 2016 Lynn Schuchter, MD Abramson Cancer Center University of Pennsylvania ASCO 2016 ABSTRACT # STUDY ID AGENT OUTCOME PRESENTER 9503 KEYNOTE 001 PEMBRO 3 YR OS, PFS, ORR 9504 KEYNOTE 006

More information

BRAF Genetic Testing to Select Melanoma or Glioma Patients for Targeted Therapy

BRAF Genetic Testing to Select Melanoma or Glioma Patients for Targeted Therapy Medical Policy Manual Genetic Testing, Policy No. 41 BRAF Genetic Testing to Select Melanoma or Glioma Patients for Targeted Therapy Next Review: August 2019 Last Review: July 2018 Effective: August 1,

More information

Melanoma maligno. Aggiornamenti in oncologia tra ricerca e clinica

Melanoma maligno. Aggiornamenti in oncologia tra ricerca e clinica Aggiornamenti in oncologia tra ricerca e clinica Melanoma maligno M. Del Vecchio Responsabile Gruppo Melanoma Dipartimento di Oncologia Medica Fondazione IRCCS Istituto Nazionale dei Tumori Milano Metastatic

More information

Melanoma: Early Detection and Therapeutic Progress

Melanoma: Early Detection and Therapeutic Progress Melanoma: Early Detection and Therapeutic Progress David W. Ollila, MD Professor of Surgery Jesse and James Millis Professor of Surgery Thanks to my collaborators, mentors and patients May 19, 2017 Disclosures:

More information

Latest Advances in the Systemic Treatment of Melanoma

Latest Advances in the Systemic Treatment of Melanoma Latest Advances in the Systemic Treatment of Melanoma Luis de la Cruz Merino Hospital Universitario Virgen Macarena OUTLINE GENERAL OVERVIEW OF MELANOMA SYSTEMIC TREATMENT IMMUNOTHERAPY * ANTI-CTLA4 *

More information

Colon cancer: Highlights. Filippo Pietrantonio Istituto Nazionale dei Tumori di Milano

Colon cancer: Highlights. Filippo Pietrantonio Istituto Nazionale dei Tumori di Milano Colon cancer: Highlights Filippo Pietrantonio Istituto Nazionale dei Tumori di Milano Agenda 1) Metastatic colorectal cancer First-line treatment molecularly unselected: FOLFOXIRI-bev (CHARTA trial) Later-line

More information

Melanoma in Focus: Update on Novel Therapy, Emerging Agents, and Optimizing Patient Care Presentation 1

Melanoma in Focus: Update on Novel Therapy, Emerging Agents, and Optimizing Patient Care Presentation 1 Presentation 1 The following is a transcript from a web-based CME -certified multimedia activity. Interactivity applies only when viewing the activity online. This activity is supported by educational

More information

National Institute for Health and Care Excellence. Single Technology Appraisal (STA)

National Institute for Health and Care Excellence. Single Technology Appraisal (STA) National Institute for Health and Care Excellence Single Technology Appraisal (STA) Nivolumab for treating advanced (unresectable or metastatic) melanoma At the scoping consultation stage, the scopes for

More information

Metastatic NSCLC: Expanding Role of Immunotherapy. Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian

Metastatic NSCLC: Expanding Role of Immunotherapy. Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian Metastatic NSCLC: Expanding Role of Immunotherapy Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian Disclosures: No relevant disclosures Please note that some of the studies reported in

More information

Metastasectomy for Melanoma What s the Evidence and When Do We Stop?

Metastasectomy for Melanoma What s the Evidence and When Do We Stop? Metastasectomy for Melanoma What s the Evidence and When Do We Stop? Vernon K. Sondak, M D Chair, Moffitt Cancer Center Tampa, Florida Focus on Melanoma London, UK October 15, 2013 Disclosures Dr. Sondak

More information

vemurafenib 240mg film-coated tablet (Zelboraf ) SMC No. (792/12) Roche Products Ltd.

vemurafenib 240mg film-coated tablet (Zelboraf ) SMC No. (792/12) Roche Products Ltd. Resubmission vemurafenib 240mg film-coated tablet (Zelboraf ) SMC No. (792/12) Roche Products Ltd. 08 November 2013 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product

More information

Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care

Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care Targeted/Immunotherapy & Molecular Profiling State-of-the-art in Cancer Care Manmeet Ahluwalia, MD, FACP Miller Family Endowed Chair in Neuro-Oncology Director Brain Metastasis Research Program Cleveland

More information