GENETIC TESTING WHAT I SHOULD KNOW. COMPREHENSIVEDx CLEAR. BRCADx/BREASTDx CLEAR. COLODx CLEAR. LYNCHDx CLEAR SPECIALTY MEDICAL LAB

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1 GENETIC TESTING WAT I SOULD KNOW COMPREENSIVEDx CLEAR BRDx/BREASTDx CLEAR COLODx CLEAR LYNCDx CLEAR SPECIALTY MEDIL LAB

2 BENEFITS OF GENETIC TESTING Genetic testing provides physicians with the ability to detect potentially life-changing health risks ahead of standard testing procedures and diagnosis. There are benefits whether the results are positive or negative for a gene mutation. aving a gene mutation may increase your risk to develop cancer by up to 80%. Test results can provide a sense of relief from uncertainty or help people make informed decisions about managing their health care. ereditary Cancers account for 5-0% of all cancers Initiate the process of detection and prevention Identifies increased risk for a multiple cancer diagnosis Customize a personal plan for optimal lifestyle, medical and nutritional changes Improves diagnosis and treatment plans for a more personalized approach to medicine Can influence reproductive decisions for family planning A gene mutation is a permanent alteration in the DNA sequence that makes up a gene. Speak with your physician to find out if you are eligibile for DNA testing. Understand what your test results mean to you.

3 COMPREENSIVEDx CLEAR COMPREENSIVEDx CLEAR analyzes 36 genes in one of the most comprehensive tests offered in the industry. Chart of Genes Tested vs. Cancer Types Cancers AP C AT M BA P BA R BM D PR BR A BR BR 2 IP CD CD CD K4 KN C 2A E DI K2 CE EP R FA M NC ML C MR E MS A MS 2 MU 6 TY NB N PA LB PM 2 S PO 2 LD PO LE PT E RA N D5 RA 0 D5 RA C D5 SD D A SD B SD SD C D SM AD ST 4 K TP 53 Genes BREAST OVARIAN COLORECTAL ENDOMETRIAL MELANOMA PANCREATIC STOMAC PROSTATE OTER WO MAY QUALIFY FOR TIS TEST MUTATION POSITIVE MANAGEMENT Multiple personal cancers at an early onset 50 Multiple early cancers in first or second degree relatives with early onset 50 Recurrence of personal cancers at any age after first diagnosis 50 Two or more relatives with associated cancers, with one diagnosed 50 yrs Seek genetic counseling to help understand your results and develop treatment plans in conjunction with your primary care physician Increased and screenings targeted cancer Chemopreventive medicines Clinical trials are encouraged for patients with a cancer diagnosis Test Title: COMPREENSIVEDx Clear Order Choice (Lab Test ID): 248 Any information contained herein should not be substituted and relied upon in the absence of actual consultation and testing by a licensed and qualified physician.

4 BRDx/BREASTDx CLEAR BRDx / BREASTDx CLEAR is a hereditary cancer panel designed for individuals suspected to be at-risk for hereditary breast and ovarian cancer. Chart of Genes Tested vs. Cancer Types Cancers AT M BA RD BR BR BR 2 IP CD C EK FA 2 N MR CC E NB A N PA LB PT 2 E RA N D RA 5C D5 ST D K TP 53 Genes BREAST OVARIAN COLORECTAL ENDOMETRIAL MELANOMA PANCREATIC STOMAC PROSTATE OTER WO MAY QUALIFY FOR TIS TEST Personal diagnosis of ovarian cancer A known mutation of the BR /2 gene in the Family Early age personal breast cancer <45 Breast cancer at any age with multiple early breast or ovarian cancers in first or second degree relatives Individuals of Ashkenazi Jewish descent with breast, ovarian or pancreatic cancer at any age Test Title: BREASTDx Clear Order Choice (Lab Test ID): 250 MUTATION POSITIVE MANAGEMENT Seek genetic counseling to help understand your results and develop treatment plans in conjunction with your primary care physician Clinical breast exams every 6-2 months starting at age 25 Ages 30-75, annual mammogram and breast MRI screening with contrast Clinical trials are encouraged for patients with a cancer diagnosis Test Title: BRDx Clear Order Choice (Lab Test ID): 249 Any information contained herein should not be substituted and relied upon in the absence of actual consultation and testing by a licensed and qualified physician.

5 LYNCDx CLEAR LYNCDx CLEAR is a hereditary cancer panel designed for individuals suspected to be at-risk for Lynch syndrome. Chart of Genes Tested vs. Cancer Types Cancers EP ML M MS MS 2 PM 6 S2 Genes BREAST OVARIAN COLORECTAL ENDOMETRIAL MELANOMA PANCREATIC STOMAC PROSTATE OTER WO MAY QUALIFY FOR TIS TEST Personal diagnosis of colorectal cancer (CRC) at an early onset 50 igh MSI histology and/or abnormal IC results Endometrial cancer 50 3 close relatives with a CRC related cancer First degree family member with a known mutation MUTATION POSITIVE MANAGEMENT Seek genetic counseling to help understand your results and develop treatment plans in conjunction with your primary care physician Colonoscopy beginning at age Consider annual urinalysis starting at Clinical trials are encouraged for patients with a cancer diagnosis Test Title: LYNCDx Clear Order Choice (Lab Test ID): 252 Any information contained herein should not be substituted and relied upon in the absence of actual consultation and testing by a licensed and qualified physician.

6 COLODx CLEAR COLODx CLEAR is a hereditary cancer panel designed for individuals suspected to be at-risk for colorectal cancer. Chart of Genes Tested vs. Cancer Types Cancers AP C BM P EP R ML M MS MS 2 6 MU TY PM S PO 2 LD PO LE PT E SM N AD ST 4 K TP 53 Genes BREAST OVARIAN COLORECTAL ENDOMETRIAL MELANOMA PANCREATIC STOMAC PROSTATE OTER WO MAY QUALIFY FOR TIS TEST Personal diagnosis of colorectal cancer (CRC) at an early onset 50 igh MSI histology and/or abnormal IC results Endometrial cancer 50 3 close relatives with a CRC related cancer First degree family member with a known mutation MUTATION POSITIVE MANAGEMENT Seek genetic counseling to help understand your results and develop treatment plans in conjunction with your primary care physician Colonoscopy beginning at age Consider annual urinalysis starting at Clinical trials are encouraged for patients with a cancer diagnosis Test Title: COLODx Clear Order Choice (Lab Test ID): 25 Any information contained herein should not be substituted and relied upon in the absence of actual consultation and testing by a licensed and qualified physician.

7 WAT TO EXPECT Determine if you are eligible for DNA testing using our electronic software. No filling out paperwork, or taking it home with you. Takes a couple of minutes to complete. 2 Collect a saliva or blood sample in the physicians office. This only takes a few minutes to complete. 3 Laboratory testing takes on average 4-2 days to complete a full DNA sequencing test. 4 Your test results are analyzed, converted into a comprehensive report, and then delivered your physicians office. Your physician 5 will schedule a follow-up appointment with you to discuss the results of your DNA test. If a mutation is discovered, you will be able to discuss proactive treatment with your doctor.

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