Treatment Modalities in Lung Cancer

Transcription

1 Workshop on Combined Radiotherapy and Chemotherapy Modalities in Lung Cancer, organised by the International Association for the Study of Lung Cancer (IASLC), Le Havre, June 9-13, 1987 Treatment Modalities in Lung Cancer Volume Editors R. Arriagada, Villejuif T. Le Chevalier, Villejuif Associate Editors J.R. Bertino, New York, N.Y.; N.M. Bleehen, Cambridge; J.H. Goldie, Vancouver; H.H. Hansen, Copenhagen; D.C. Ihde, Bethesda, Md. 40 figures and 50 tables, 1988 Basel Miinchen Paris London New York NewDelhi Singapore Tokyo Sydney

2 List of Participants XI Inaugural Conference Tubiana, M. (Villejuif): The Combination of Radiotherapy and Chemotherapy.. 1 Mathematical Models Goldie, J.H.; Coldman, A.J.; Ng, V. (Vancouver, B.C.); Hopkins, H.A.; Looney, W.B. (Charlottesville, Va.): A Mathematical and Computer-Based Model of Alternating Chemotherapy and Radiation Therapy in Experimental Neoplasms 11 Souhami, R.L.; Gregory, W.M.; Birkhead, B.G. (London): Mathematical Models in High-Dose Chemotherapy 21 Biological Bases and Mechanisms of Cell Resistance to Therapy Bertino, J.R. (New York, N. Y.): Review of Mechanisms of Cell Resistance to Therapy in Lung Cancer 29 Looney, W.B.; Hopkins, H.A. (Charlottesville, Va.): The Relationship of Experimental, Theoretical and Clinical Studies of Alternating Chemotherapy and Radiotherapy in the Management of Lung Cancer 35 Milas, L. (Houston, Tex.): Effects of Radiotherapy and Chemotherapy on Tumor Bed Stroma.." 48

3 VIII Treatment Response Evaluation and Statistical Analysis Sorensen, J.B.; Hansen, H.H. (Copenhagen): Review of Methodological Problems in the Interpretation of Phase II Trials in Nonsmall-Cell Lung Cancer 57 Ihde, D.C. (Bethesda, Md.): How Should We Report Results of Clinical Trials of Combined Chemotherapy and Chest Irradiation in Limited Stage Small Cell Lung Cancer? 65 Choi, N.C.; Carey, R.W. (Boston, Mass.): Reassessment of Loco-Regional Failure Rate in Relation with Radiation Dose in Combined Modality Approach of Multidrug Chemotherapy and Radiotherapy for Limited Stage Small-Cell Lung Carcinoma 70 Souhami, R.L.; Earl, H.M.; Ash, CM.; Spiro, S.G.; Geddes, D.; Harper, P.G.; Tobias, J.S. (London): Prognostic Factors in Patients with Small-Cell Lung Cancer: Preliminary Results from a Large Randomised Study 77 B6nichou, J.; Chastang, C. (Paris): Use of the Triangular Test in the Analysis of Randomized Clinical Trials when the Response Criterion is Censored: Application to Two Trials in Lung Cancer 83 Concurrent Combinations Ihde, D.C; Seifter, E.J.; Johnson, B.E.; Glatstein, E. (Bethesda, Md.): Review of Concurrent Chemotherapy/Radiotherapy Combinations in Small Cell Lung Cancer 92 Payne, D.G.; Feld, R. (Toronto, Ont.): Concurrent Radiotherapy and Chemotherapy in Lung Cancer at the Princess Margaret Hospital 96 Lange, O.F. (Bonn): Concurrent Chemo-Radiotherapy in Small Cell Lung Cancer. 102 Turrisi, A.T.; Glover, D.J.; Mason, B.A. (Philadelphia, Pa.): Concurrent Twice- Daily Radiotherapy Plus Platinum-Etoposide Chemotherapy for the Treatment of Limited Small Cell Lung Cancer: A Preliminary Report 109 Sequential Combinations Bleehen, N.M. (Cambridge): Review of Sequential Radio-Chemotherapy Schedules in the Treatment of Lung Cancer 115 Trovo, M.G.; Veronesi, A.; Bortolus, R.; Roncadin, M.; De Paoli, A.; Franchin, G.; Grigoletto, E.; Minatel, E. (Aviano): Is Chemotherapy Necessary in the Management of Unresectable Nonmetastatic Nonsmall-Cell Lung Cancer? Van Houtte, P.; Klastersky, J. (Brussels); Renaud, A.; Michel, J. (La Louvriere); Vandermoten, G.; Nguyen, H.; Sculier, J.P.; Devriendt, J.; Mommen, P. (Brussels): Induction Chemotherapy with Cisplatin, Etoposide and Vindesine before Radiiiiation Therapy for Nonsmall-Cell Lung Cancer. A Randomized Study. 131 Thomas, F.; Le Chevalier, T.; Arriagada, R.; Ruffie\ P.; Baldeyrou, P. (Villejuif): Should Chemotherapy Response Be Evaluated Separately in Sequential Chemotherapy-Radiotherapy Schedules in Locally Advanced Nonsmall-Cell Lung Carcinoma? 138 Aisner, J. (Baltimore, Md.): Combined Modalities in the Treatment of Small Cell Carcinoma of the Lung. A Review of Current Standings 142

4 IX Unconventional Combinations Arriagada, R. (Villejuif): Review of Unconventional Combinations of Radiotherapy and Chemotherapy in Lung Cancer 150 Souhami, R.L.; Ash, CM.; Earl, H.M.; Harper, P.G.; Geddes, D.; Tobias, J.S.; Spiro, S.G. (London): Intensive Chemotherapy and Thoracic Irradiation as Induction Treatment in Limited-Stage Small-Cell Lung Cancer 155 Dionet, C; Verrelle, P.; Roux, D.; Fraysse, P.; Achard, J.-L.; Beaupain, R.; Rozan, R. (Clermont-Ferrand): Role of Small Doses of Radiotherapy Combined with Chemotherapy in Non-Small Cell Lung Cancer 163 Hurman, D.C; Urtasun, R.C; Belch, A.R.; Kinney, B.; Amy, R.; Hanson, J. (Alberta, Ed.); Feldstein, M. (Boston, Mass.): Sequential Wide Field Irradiation and Systemic Chemotherapy as Part of the Induction Treatment of Small Cell Lung Cancer 168 Looney, W.B.; Hopkins, H.A. (Charlottesville, Va.): The Integration of Multifractionated Radiotherapy into Combined Chemotherapeutic-Radiotherapeutic s Approaches to Lung Cancer Treatment 176 Scher, H.; Gralla, R.; Linares, L.; Kris, M.; Heelan, R.; Shank, B. (New York, N.Y.): Preliminary Results of Combination Chemotherapy and Sequential Accelerated Fractionation Radiation Therapy in Limited-Stage Small Cell Carcinoma of the Lung. Evaluation of Measures for Reduction of Toxicity and Effect on Complete Response Rate 184 Le Chevalier, T.; Arriagada, R.; Thomas, F.; Baldeyrou, P.; Ruffle, P. (Villejuif); Cremoux, H. de; Martin, M. (Creteil); Cerrina, M.L. (Clamart); De The\ H.; Tarayre, M.; Sancho-Garnier, H.; GROP (Villejuif): Experience of the Institut Gustave-Roussy in Alternating Radiotherapy and Chemotherapy Schedules as Induction Treatment in Limited Small-Cell Lung Cancer 190 Arriagada, R.; De Th6, H.; Thomas, F. (Villejuif); Cremoux, H. de (Cr&eil); Dewar, J.; Sancho-Garnier, H.; Le Chevalier, T.; GROP (Villejuif): Prognostic Value of Initial Chemotherapy Doses in Limited Small Cell Lung Cancer 194 Treatment Toxicity and Long-Term Sequelae Le Chevalier, T. (Villejuif): Review of Toxicity and Long-Term Sequelae in Lung Cancer 199 Feld, R.; Payne, D.; Hodson, I.; Coy, P. for the NCI Clinical Trials Group (Toronto, Ont.): Complications of Treatment of Small Cell Carcinoma of the Lung Johnson, B.E.; Glatstein, E.; Ihde, D.C. (Bethesda, Md.): The National Cancer Institute Experience with Early and Late Effects of Combined Modality Therapy in Small Cell Lung Cancer 210 Choi, N.C; Kanarek, D.J.; Kazemi, H. (Boston, Mass.): Prospective Study of Pulmonary Tolerance to Radiotherapy or Radiotherapy plus Multidrug Chemotherapy for Loco-Regional Lung Carcinoma 213 Souhami, R.L.; Morittu, L.; Ash, CM.; Earl, H.; Geddes, D.; Harper, P.G.; Tobias, J.S.; Spiro, S.G. (London): Identification of Patients at High Risk of Chemotherapy-Induced Toxicity in Small-Cell Lung Cancer 220

5 X Kaasa, S.; Olsnes, B.T.; Thorud, E.; Hast, H. (Oslo): Reduced Short-Term Neuropsychological Performance in Patients with Nonsmall-Cell Lung Cancer Treated with Cisplatin and Etoposide 226 Consensus Report Arriagada, R.; Bertino, J.R.; Bleehen, N.M.; Brodin, O.; Feld, R.; Goldie, J.H.; Hansen, H.H.; Ihde, D.C; Le Chevalier, T.; Souhami, R.L. and the Workshop Participants: Consensus Report on Combined Radiotherapy and Chemotherapy Modalities in Lung Cancer 232 Subject Index 242