Genetic Testing for Lynch Syndrome

Size: px
Start display at page:

Download "Genetic Testing for Lynch Syndrome"

Transcription

1 Genetic Testing for Lynch Syndrome MP9487 Covered Service: Prior Authorization Required: Additional Information: Yes when meets criteria below Yes-as shown below Pre and post-test genetic counseling is required for any individual undergoing genetic testing for hereditary breast and ovarian cancer syndromes. Allowed once per lifetime in adults 18 years of age or older. A first-degree relative is defined as an individual s parents, full siblings, and children. A second-degree relative is defined as an individual s grandparents, grandchildren, aunts, uncles, nephews, nieces and half-siblings. A third-degree relative is defined as first cousins, great-aunts, great-uncles, great-grandchildren, or great-grandparents. Prevea360 Health Plan Medical Policy: 1.0 Genetic testing for Lynch Syndrome (EPCAM, MLH1, MSH2, MSH6 and PMS2) requires prior authorization through the Quality and Care and is considered medically necessary when one (1) of the following (1.1 to 1.6) are met: 1.1 First degree, second degree or third degree relative of person with known EPCAM, MLH1, MSH2, MSH6 or PMS2 gene mutation by DNA sequence testing, when testing is targeted to the known familial mutation; OR. 1.2 Personal history of colorectal cancer or endometrial cancer with high microsatellite instability or pathologic immunohistochemistry on cancer tissue testing, when testing is targeted to the gene(s) of suspicion based on the results of the tumor testing; OR. 1.3 Personal history in which the revised Bethesda guidelines are met and one of the following are met: Colorectal cancer diagnosed under age 50; OR Presence of synchronous (simultaneous), metachronous (diagnosed at different times) colorectal, or other Lynch syndrome related cancer**, regardless of age; OR Colorectal cancer with the MSI-H histology diagnosed in an individual who Genetic Testing for Lynch Syndrome 1 of 5 Underwritten by Dean Health Plan, Inc.

2 is under age 60; OR Colorectal cancer diagnosed in a patient with one or more first-degree relatives with a Lynch syndrome related cancer**, with one of the cancers diagnosed under age 50; OR Colorectal cancer diagnosed in a patient with two or more first- or seconddegree relatives with a Lynch syndrome related cancer**, regardless of age. 1.4 Individual with endometrial cancer diagnosed before age Individual with 5% risk of Lynch syndrome on a mutation prediction model (i. e. MMRpro, PREMM(1,2,6) or MMRpredict). 1.6 An individual without a personal history of cancer who has family history of ANY of the following, and none of the affected relatives are available for genetic testing: At least one first degree relative with colorectal or endometrial cancer diagnosed before age 50; OR At least one first-degree relative with colorectal or endometrial cancer and another synchromous or metachronous Lynch sysndrome related cancer**; OR At least two first or second degree relatives with Lynch syndromerelated cancers, with one that was diagnosed prior to age 50; OR At least three first or second degree relatives with Lynch syndrome related cancers** at any age. 2.0 When testing for Lynch syndrome is considered medically necessary, Dean Health Plan will cover the following Lynch syndrome genes with associated CPT codes: EPCAM (81479,81403), MLH1 (81292,81294), MSH2 (81295,81297 ), MSH6 (81298,81300), PMS2 ( 81317,81319 ). 3.0 Prevea360 Health Plan considers multigene hereditary cancer panels that accompany Lynch syndrome genes experimental and investigational and therefore are not medically necessary. There is insufficient published evidence to support their clinical utility and validity. The only Lynch syndrome panels that are considered medically necessary are the five genes noted above exclusively. NOTE: ** Lynch-related cancers: colorectal, endometrial, keratocanthoma, stomach, ovarian, small bowel, ureter or renal pelvis, sebaceous adenoma or carcinoma, hepatobiliary, pancreas, brain cancer. CPT/HCPCS Codes Related to MP9487 * The list of codes (and their descriptors, if any) is provided for informational purposes only and may not be all inclusive or current. Listing of a code in this medical policy does not imply that the service described by the code is a covered or non-covered service. Benefit coverage for any service is determined by the member s policy of health coverage with Genetic Testing for Lynch Syndrome 2 of 5 Underwritten by Dean Health Plan, Inc.

3 Prevea360 Health Plan. Inclusion of a code above does not imply any right to reimbursement or guarantee claim payment. Other medical policies may also apply BRCA1, BRCA2 (breast cancer 1 and 2) (eg, hereditary breast and ovarian cancer) gene analysis; full and full duplication/deletion analysis APC (adenomatous polyposis coli) (eg, familial adenomatosis polyposis [FAP], attenuated FAP) gene analysis; full gene sequence APC (adenomatous polyposis coli) (eg, familial adenomatosis polyposis [FAP], attenuated FAP) gene analysis; MLH1 (mutl homolog 1, colon cancer, nonpolyposis type 2) (eg, hereditary promoter methylation analysis MLH1 (mutl homolog 1, colon cancer, nonpolyposis type 2) (eg, hereditary full MLH1 (mutl homolog 1, colon cancer, nonpolyposis type 2) (eg, hereditary MLH1 (mutl homolog 1, colon cancer, nonpolyposis type 2) (eg, hereditary MSH2 (muts homolog 2, colon cancer, nonpolyposis type 1) (eg, hereditary full MSH2 (muts homolog 2, colon cancer, nonpolyposis type 1) (eg, hereditary MSH2 (muts homolog 2, colon cancer, nonpolyposis type 1) (eg, hereditary MSH6 (muts homolog 6 [E. coli]) (eg, hereditary non-polyposis colorectal cancer, Lynch syndrome) gene analysis; full Genetic Testing for Lynch Syndrome 3 of 5 Underwritten by Dean Health Plan, Inc.

4 81299 MSH6 (muts homolog 6 [E. coli]) (eg, hereditary non-polyposis colorectal cancer, Lynch syndrome) gene analysis; known MSH6 (muts homolog 6 [E. coli]) (eg, hereditary non-polyposis colorectal cancer, Lynch syndrome) gene analysis; Microsatellite instability analysis (eg, hereditary non-polyposis colorectal cancer, Lynch syndrome) of markers for mismatch repair deficiency (eg, BAT25, BAT26), includes comparison of neoplastic and normal tissue, if performed PMS2 (postmeiotic segregation increased 2 [S. cerevisiae]) (eg, hereditary full PMS2 (postmeiotic segregation increased 2 [S. cerevisiae]) (eg, hereditary PMS2 (postmeiotic segregation increased 2 [S. cerevisiae]) (eg, hereditary Molecular Pathology Procedure Level Hereditary colon cancer disorders (eg, Lynch syndrome, PTEN hamartoma syndrome, Cowden syndrome, familial adenomatosis polyposis); genomic panel, must include sequencing of at least 10 genes, including APC, BMPR1A, CDH1, MLH1, MSH2, MSH6, MUTYH, PTEN, SMAD4, and STK Hereditary colon cancer disorders (eg, Lynch syndrome, PTEN hamartoma syndrome, Cowden syndrome, familial adenomatosis polyposis); duplication/deletion analysis panel, must include analysis of at least 5 genes, including MLH1, MSH2, EPCAM, SMAD4, and STK Unlisted molecular pathology procedure Genetic Testing for Lynch Syndrome 4 of 5 Underwritten by Dean Health Plan, Inc.

5 Originated: Revised: Reviewed: Committee/Source Date(s) April 3, 2017 December 20, 2017 June 20, 2018 December 20, 2017 June 20, 2018 Published/Effective: 07/01/2018 Genetic Testing for Lynch Syndrome 5 of 5 Underwritten by Dean Health Plan, Inc.

Prior Authorization. Additional Information:

Prior Authorization. Additional Information: Genetic Testing for Lynch Syndrome MP9487 Covered Service: Prior Authorization Required: Additional Information: Yes when meets criteria below Yes-as shown below Pre and post test genetic counseling is

More information

Yes when meets criteria below. Dean Health Plan covers when Medicare also covers the benefit.

Yes when meets criteria below. Dean Health Plan covers when Medicare also covers the benefit. Genetic Testing for Lynch Syndrome MP9487 Covered Service: Prior Authorization Required: Additional Information: Yes when meets criteria below Yes-as shown below Pre and post test genetic counseling is

More information

Genetic Testing for BRCA1 and BRCA2 Genes

Genetic Testing for BRCA1 and BRCA2 Genes Genetic Testing for BRCA1 and BRCA2 Genes MP9478 Covered Service: Prior Authorization Required: Additional Information: Yes when meets criteria below Yes as shown below Pre and post-test genetic counseling

More information

Prior Authorization. Additional Information:

Prior Authorization. Additional Information: Genetic Testing for Cowden Syndrome - PTEN Gene MP9488 Covered Service: Prior Authorization Required: Additional Information: Yes when meets criteria below Yes as shown below Pre and post-test genetic

More information

Policy Specific Section: Medical Necessity and Investigational / Experimental. October 14, 1998 March 28, 2014

Policy Specific Section: Medical Necessity and Investigational / Experimental. October 14, 1998 March 28, 2014 Medical Policy Genetic Testing for Colorectal Cancer Type: Medical Necessity and Investigational / Experimental Policy Specific Section: Laboratory/Pathology Original Policy Date: Effective Date: October

More information

Subject: Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes

Subject: Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes 05-82000-31 Original Effective Date: 10/15/01 Reviewed: 10/25/18 Revised: 11/15/18 Subject: Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes THIS MEDICAL COVERAGE GUIDELINE

More information

Genetic Testing for BRCA1 and BRCA2 Genes

Genetic Testing for BRCA1 and BRCA2 Genes Genetic Testing f BRCA1 and BRCA2 Genes MP9478 Covered Service: Pri Authization Required: Additional Infmation: Yes when meets criteria below Yes--as shown below Pre and post-test genetic counseling is

More information

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Policy Number: Original Effective Date: MM.02.007 09/01/2011 Line(s) of Business: Current Effective Date: HMO; PPO; QUEST Integration

More information

CLINICAL MEDICAL POLICY

CLINICAL MEDICAL POLICY Policy Name: Policy Number: Approved By: CLINICAL MEDICAL POLICY Genetic Testing for Colorectal Cancer Susceptibility MP-018-MD-DE Provider Notice Date: 11/1/2016 Original Effective Date: 12/1/2016 Annual

More information

Hereditary Non Polyposis Colorectal Cancer(HNPCC) From clinic to genetics

Hereditary Non Polyposis Colorectal Cancer(HNPCC) From clinic to genetics From clinic to genetics Question 1) Clinical pattern of inheritance of the HNPCC-Syndrome? Question 1) Clinical pattern of inheritance of the HNPCC-Syndrome? Autosomal dominant Question 2) Incidence of

More information

MEDICAL POLICY SUBJECT: GENETIC TESTING FOR INHERITED SUSCEPTIBILITY TO COLORECTAL CANCER. POLICY NUMBER: CATEGORY: Laboratory Test

MEDICAL POLICY SUBJECT: GENETIC TESTING FOR INHERITED SUSCEPTIBILITY TO COLORECTAL CANCER. POLICY NUMBER: CATEGORY: Laboratory Test MEDICAL POLICY SUBJECT: GENETIC TESTING FOR INHERITED SUSCEPTIBILITY TO COLORECTAL CANCER POLICY NUMBER: 2.02.11 CATEGORY: Laboratory Test EFFECTIVE DATE: 09/16/99 REVISED DATE: 04/19/01, 05/16/02, 06/19/03,

More information

CLINICAL MEDICAL POLICY

CLINICAL MEDICAL POLICY Policy Name: Policy Number: Responsible Department(s): CLINICAL MEDICAL POLICY Genetic Testing for Colorectal Cancer Susceptibility MP-018-MD-DE Medical Management Provider Notice Date: 10/01/2017 Original

More information

Content. Diagnostic approach and clinical management of Lynch Syndrome: guidelines. Terminology. Identification of Lynch Syndrome

Content. Diagnostic approach and clinical management of Lynch Syndrome: guidelines. Terminology. Identification of Lynch Syndrome of Lynch Syndrome: guidelines 17/03/2009 Content Terminology Lynch Syndrome Presumed Lynch Syndrome Familial Colorectal Cancer Identification of Lynch Syndrome Amsterdam II criteria Revised Bethesda Guidelines

More information

CLINICAL MEDICAL POLICY

CLINICAL MEDICAL POLICY CLINICAL MEDICAL POLICY Policy Name: Genetic Testing for Colorectal Cancer Susceptibility Policy Number: MP-018-MD-WV Responsible Department(s): Medical Management Provider Notice Date: 10/01/2017; 11/01/2016

More information

Lynch Syndrome. Angie Strang, PGY2

Lynch Syndrome. Angie Strang, PGY2 Lynch Syndrome Angie Strang, PGY2 Background Previously hereditary nonpolyposis colorectal cancer Autosomal dominant inherited cancer susceptibility syndrome Caused by defects in the mismatch repair system

More information

Medical Policy An Independent Licensee of the Blue Cross and Blue Shield Association

Medical Policy An Independent Licensee of the Blue Cross and Blue Shield Association Genetic Testing for Inherited Susceptibility to Colon Cancer Page 1 of 24 Medical Policy An Independent Licensee of the Blue Cross and Blue Shield Association Title: Genetic Testing for Inherited Susceptibility

More information

COLON CANCER & GENETICS VERMONT COLORECTAL CANCER SUMMIT NOVEMBER 15, 2014

COLON CANCER & GENETICS VERMONT COLORECTAL CANCER SUMMIT NOVEMBER 15, 2014 COLON CANCER & GENETICS VERMONT COLORECTAL CANCER SUMMIT NOVEMBER 15, 2014 WENDY MCKINNON, MS, CGC CERTIFIED GENETIC COUNSELOR FAMILIAL CANCER PROGRAM UNIVERSIT Y OF VERMONT MEDICAL CENTER 1 CHARACTERISTICS

More information

PROVIDER POLICIES & PROCEDURES

PROVIDER POLICIES & PROCEDURES PROVIDER POLICIES & PROCEDURES GENETIC CANCER SUSCEPTIBILITY PANELS USING NEXT GENERATION SEQUENCING The purpose of this document is to assist providers enrolled in the Connecticut Medical Assistance Program

More information

Genetic testing all you need to know

Genetic testing all you need to know Genetic testing all you need to know Sue Clark Consultant Colorectal Surgeon, St Mark s Hospital, London, UK. Colorectal cancer Familial 33% Polyposis syndromes

More information

Colonic polyps and colon cancer. Andrew Macpherson Director of Gastroentology University of Bern

Colonic polyps and colon cancer. Andrew Macpherson Director of Gastroentology University of Bern Colonic polyps and colon cancer Andrew Macpherson Director of Gastroentology University of Bern Improtance of the problem of colon cancers - Epidemiology Lifetime risk 5% Incidence/10 5 /annum (US Detroit

More information

Risk of Colorectal Cancer (CRC) Hereditary Syndromes in GI Cancer GENETIC MALPRACTICE

Risk of Colorectal Cancer (CRC) Hereditary Syndromes in GI Cancer GENETIC MALPRACTICE Identifying the Patient at Risk for an Inherited Syndrome Sapna Syngal, MD, MPH, FACG Director, Gastroenterology Director, Familial GI Program Dana-Farber/Brigham and Women s Cancer Center Associate Professor

More information

National Medical Policy

National Medical Policy National Medical Policy Subject: Policy Number: Genetic Testing for Hereditary Nonpolyposis Colorectal Cancer (HNPCC) (Lynch Syndrome) NMP137 Effective Date*: April 2004 Updated: March 2017 This National

More information

The benefit of. knowing. Genetic testing for hereditary cancer. A patient support guide

The benefit of. knowing. Genetic testing for hereditary cancer. A patient support guide The benefit of knowing Genetic testing for hereditary cancer A patient support guide Does cancer run in your family? Cancer is more common in some families. Sometimes cancer is caused by a change in a

More information

FACT SHEET 49. What is meant by a family history of bowel cancer? What is bowel cancer? What causes bowel cancer?

FACT SHEET 49. What is meant by a family history of bowel cancer? What is bowel cancer? What causes bowel cancer? Important points The most important factors that can influence an individual s chance of developing bowel cancer are getting older and having a family history of bowel cancer A family history of bowel

More information

Medical Policy An independent licensee of the Blue Cross Blue Shield Association

Medical Policy An independent licensee of the Blue Cross Blue Shield Association Genetic Testing for Lynch Syndrome and Other Inherited Page 1 of 34 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Genetic Testing for Lynch Syndrome and Other

More information

COLON CANCER GENETICS (FOR SURGEONS) Mark W. Arnold MD Chief, Division of Colon and Rectal Surgery Professor of Surgery The Ohio State University

COLON CANCER GENETICS (FOR SURGEONS) Mark W. Arnold MD Chief, Division of Colon and Rectal Surgery Professor of Surgery The Ohio State University COLON CANCER GENETICS (FOR SURGEONS) Mark W. Arnold MD Chief, Division of Colon and Rectal Surgery Professor of Surgery The Ohio State University 1. I am a surgeon; of course I have nothing to disclose.

More information

Familial and Hereditary Colon Cancer

Familial and Hereditary Colon Cancer Familial and Hereditary Colon Cancer Aasma Shaukat, MD, MPH, FACG, FASGE, FACP GI Section Chief, Minneapolis VAMC Associate Professor, Division of Gastroenterology, Department of Medicine, University of

More information

CentoCancer STRIVE FOR THE MOST COMPLETE INFORMATION

CentoCancer STRIVE FOR THE MOST COMPLETE INFORMATION CentoCancer STRIVE FOR THE MOST COMPLETE INFORMATION CentoCancer our most comprehensive oncogenetics panel for hereditary mutations Hereditary pathogenic variants confer an increased risk of developing

More information

Familial and Hereditary Colon Cancer

Familial and Hereditary Colon Cancer Familial and Hereditary Colon Cancer Aasma Shaukat, MD, MPH, FACG, FASGE, FACP GI Section Chief, Minneapolis VAMC Associate Professor, Division of Gastroenterology, Department of Medicine, University of

More information

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Policy Number: 2.04.08 Last Review: 1/2019 Origination: 1/2004 Next Review: 1/2020 Policy Blue Cross and Blue Shield of Kansas

More information

GYNplus. genetic testing for hereditary ovarian and/or uterine cancer

GYNplus. genetic testing for hereditary ovarian and/or uterine cancer GYNplus genetic testing for hereditary ovarian and/or uterine cancer What Are the Causes of Hereditary Ovarian and Uterine Cancer? uterine cancer ovarian cancer sporadic 70-80% hereditary 5% Lynch syndrome

More information

WHAT IS A GENE? CHROMOSOME DNA PROTEIN. A gene is made up of DNA. It carries instructions to make proteins.

WHAT IS A GENE? CHROMOSOME DNA PROTEIN. A gene is made up of DNA. It carries instructions to make proteins. WHAT IS A GENE? CHROMOSOME E GEN DNA A gene is made up of DNA. It carries instructions to make proteins. The proteins have specific jobs that help your body work normally. PROTEIN 1 WHAT HAPPENS WHEN THERE

More information

GYNplus: A Genetic Test for Hereditary Ovarian and/or Uterine Cancer

GYNplus: A Genetic Test for Hereditary Ovarian and/or Uterine Cancer GYNplus: A Genetic Test for Hereditary Ovarian and/or Uterine Cancer Causes of Hereditary Ovarian and Uterine Cancer uterine cancer ovarian cancer Sporadic 75-90% Sporadic 70-80% Hereditary, 5% Lynch syndrome

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: genetic_testing_for_colon_cancer 5/2004 8/2017 8/2018 8/2017 Description of Procedure or Service Genetic

More information

A Patient s Guide to Hereditary Cancer. Is Hereditary Cancer Testing Right for You?

A Patient s Guide to Hereditary Cancer. Is Hereditary Cancer Testing Right for You? A Patient s Guide to Hereditary Cancer Is Hereditary Cancer Testing Right for You? What is Hereditary Cancer? Most cancers occur in people who do not have a strong family history of that cancer. This is

More information

The Next Generation of Hereditary Cancer Testing

The Next Generation of Hereditary Cancer Testing The Next Generation of Hereditary Cancer Testing Why Genetic Testing? Cancers can appear to run in families. Often this is due to shared environmental or lifestyle patterns, such as tobacco use. However,

More information

Expert Interview: Inherited Susceptibility to Cancer with Dr. Nicoleta Voian

Expert Interview: Inherited Susceptibility to Cancer with Dr. Nicoleta Voian Expert Interview: Inherited Susceptibility to Cancer with Dr. Nicoleta Voian ANNOUNCER OPEN: Welcome to CME on ReachMD. This segment, entitled Inherited Susceptibility to Cancer: What Do Primary Care Providers

More information

TumorNext-Lynch. genetic testing for hereditary colorectal or uterine cancer

TumorNext-Lynch. genetic testing for hereditary colorectal or uterine cancer TumorNet-Lynch genetic testing for hereditary colorectal or uterine cancer What Are the Causes of Hereditary Colorectal Cancer? sporadic 70% familial 20% hereditary 10% Lynch syndrome, up to 4% Familial

More information

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Applies to all products administered or underwritten by Blue Cross and Blue Shield of Louisiana and its subsidiary, HMO Louisiana,

More information

Inherited colon cancer and other inherited cancer predispositions. Dr Anne De Leener Centre de Génétique Humaine

Inherited colon cancer and other inherited cancer predispositions. Dr Anne De Leener Centre de Génétique Humaine 14.20-15.00 Inherited colon cancer and other inherited cancer predispositions Dr Anne De Leener Centre de Génétique Humaine INHERITED COLORECTAL CANCER (CRC) Colorectal cancer 5% 1% 10% 84% Sporadic Familial

More information

B Base excision repair, in MUTYH-associated polyposis and colorectal cancer, BRAF testing, for hereditary colorectal cancer, 696

B Base excision repair, in MUTYH-associated polyposis and colorectal cancer, BRAF testing, for hereditary colorectal cancer, 696 Index Note: Page numbers of article titles are in boldface type. A Adenomatous polyposis, familial. See Familial adenomatous polyposis. Anal anastomosis, ileal-pouch, proctocolectomy with, in FAP, 591

More information

Genetic Testing of Inherited Cancer Predisposition Genetic Testing - Oncology

Genetic Testing of Inherited Cancer Predisposition Genetic Testing - Oncology Genetic Testing of Inherited Cancer Predisposition Genetic Testing - Oncology Policy Number: Original Effective Date: MM.02.010 05/01/2010 Line(s) of Business: Current Effective Date: HMO; PPO; QUEST Integration

More information

Eligibility criteria for prophylactic treatment allowance

Eligibility criteria for prophylactic treatment allowance Eligibility criteria for prophylactic treatment allowance Southern Cross will only pay the prophylactic treatment allowance for the following healthcare services when the applicable eligibility criteria

More information

Management of higher risk of colorectal cancer. Huw Thomas

Management of higher risk of colorectal cancer. Huw Thomas Management of higher risk of colorectal cancer Huw Thomas Colorectal Cancer 41,000 new cases pa in UK 16,000 deaths pa 60% 5 year survival Adenoma-carcinoma sequence (Morson) Survival vs stage (Dukes)

More information

Re: NC Medicaid and NC Health Choice Program coverage of genetic testing for susceptibility to breast and ovarian cancer

Re: NC Medicaid and NC Health Choice Program coverage of genetic testing for susceptibility to breast and ovarian cancer March 23, 2018 North Carolina (NC) Division of Medical Assistance (DMA), Clinical Policy Section C/O Pam Greeson, BSN, RN-C, pam.greeson@dhhs.nc.gov Nurse Consultant, Division of Medical Assistance Practitioners,

More information

WHAT IS A GENE? CHROMOSOME DNA PROTEIN. A gene is made up of DNA. It carries instructions to make proteins.

WHAT IS A GENE? CHROMOSOME DNA PROTEIN. A gene is made up of DNA. It carries instructions to make proteins. WHAT IS A GENE? CHROMOSOME GENE DNA A gene is made up of DNA. It carries instructions to make proteins. The proteins have specific jobs that help your body work normally. PROTEIN 1 WHAT HAPPENS WHEN THERE

More information

Hereditary Cancer Products

Hereditary Cancer Products Hereditary Products Integrated BRACAnalysis (BRCA1 and BRCA2 sequencing and large rearrangement testing (BART)), covered when: PERSONAL HISTORY of Breast (must meet at least 1) Diagnosed

More information

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Policy Number: 2.04.08 Last Review: 1/2018 Origination: 1/2004 Next Review: 1/2019 Policy Blue Cross and Blue Shield of Kansas

More information

Page 1 of 8 TABLE OF CONTENTS

Page 1 of 8 TABLE OF CONTENTS Page 1 of 8 TABLE OF CONTENTS Patient Evaluation and Recommendation..Page 2 Testing and Follow-up..Page 3 Genetic Counseling Referral Criteria.....Page 4-5 Patient Education..Page 6 Suggested Readings...Page

More information

Be Ready Pack Learn more about how Myriad myrisk is revolutionizing hereditary cancer testing.

Be Ready Pack Learn more about how Myriad myrisk is revolutionizing hereditary cancer testing. Be Ready Pack Learn more about how Myriad myrisk is revolutionizing hereditary cancer testing. Hereditary cancer and you Approximately 5% to 10% of all cancers develop because a person inherited a genetic

More information

Learn your genetic risk for the most common hereditary cancers.

Learn your genetic risk for the most common hereditary cancers. Learn your genetic risk for the most common hereditary cancers. color.com Color analyzes 30 genes including BRCA1 and BRCA2 to help women and men understand their risk for the most common hereditary cancers,

More information

LYNCH SYNDROME: IN YOUR FACE BUT LOST IN SPACE (MOUNTAIN)!

LYNCH SYNDROME: IN YOUR FACE BUT LOST IN SPACE (MOUNTAIN)! LYNCH SYNDROME: IN YOUR FACE BUT LOST IN SPACE (MOUNTAIN)! Kathryn Singh, MPH, MS, LCGC Associate Clinical Professor Assistant Director, Graduate Program in Genetic Counseling Division of Genetic and Genomic

More information

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Section 2.0 Medicine Subsection 2.04 Pathology/Laboratory

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Section 2.0 Medicine Subsection 2.04 Pathology/Laboratory 2.04.08 Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Section 2.0 Medicine Subsection 2.04 Pathology/Laboratory Effective Date January 30, 2015 Original Policy Date October

More information

Case Presentation Diana Lim, MBBS, FRCPA, FRCPath Senior Consultant Department of Pathology, National University Health System, Singapore Assistant Pr

Case Presentation Diana Lim, MBBS, FRCPA, FRCPath Senior Consultant Department of Pathology, National University Health System, Singapore Assistant Pr Case Presentation Diana Lim, MBBS, FRCPA, FRCPath Senior Consultant Department of Pathology, National University Health System, Singapore Assistant Professor Yong Loo Lin School of Medicine, National University

More information

Hereditary Cancer Update: What do GPOs need to know?

Hereditary Cancer Update: What do GPOs need to know? Hereditary Cancer Update: What do GPOs need to know? Mary McCullum, RN, MSN, CON(C) Nurse Educator, Hereditary Cancer Program BC Cancer Agency October 1, 2016 Conflict of Interest Disclosure Nothing to

More information

Hereditary Gastric Cancer

Hereditary Gastric Cancer Hereditary Gastric Cancer Dr Bastiaan de Boer Consultant Pathologist Department of Anatomical Pathology PathWest Laboratory Medicine, QE II Medical Centre Clinical Associate Professor School of Pathology

More information

GENETIC TESTING FOR HEREDITARY CANCER

GENETIC TESTING FOR HEREDITARY CANCER UnitedHealthcare Oxford Clinical Policy GENETIC TESTING FOR HEREDITARY CANCER Policy Number: DIAGNOSTIC 004.27 T2 Effective Date: November 1, 2017 Table of Contents Page INSTRUCTIONS FOR USE... 1 CONDITIONS

More information

Lynch Syndrome (HNPCC) and MYH-Associated Polyposis (MAP)

Lynch Syndrome (HNPCC) and MYH-Associated Polyposis (MAP) Lynch Syndrome (HNPCC) and MYH-Associated Polyposis (MAP) A Patient s Guide to risk assessment Hereditary Cancer Testing: Is it Right for You? This workbook is designed to help you decide if hereditary

More information

Colorectal Cancer - Working in Partnership. David Baty Genetics, Ninewells Hospital

Colorectal Cancer - Working in Partnership. David Baty Genetics, Ninewells Hospital Colorectal Cancer - Working in Partnership David Baty Genetics, Ninewells Hospital Genetics and Pathology National initiatives Colorectal cancer Inherited CRC Sporadic CRC The Liquid Biopsy The future?

More information

Code CPT Descriptor Test Purpose and Method Crosswalk Recommendation SEPT9 (Septin9) (e.g., colorectal cancer) methylation analysis

Code CPT Descriptor Test Purpose and Method Crosswalk Recommendation SEPT9 (Septin9) (e.g., colorectal cancer) methylation analysis ASSOCIATION FOR MOLECULAR PATHOLOGY Education. Innovation & Improved Patient Care. Advocacy. 9650 Rockville Pike. Bethesda, Maryland 20814 Tel: 301-634-7939 Fax: 301-634-7995 amp@amp.org www.amp.org August

More information

Myriad Financial Assistance Program (MFAP)

Myriad Financial Assistance Program (MFAP) Myriad Financial Assistance Program (MFAP) MEDICAL CRITERIA Hereditary Cancer Products The Myriad Financial Assistance Program offers aid to patients who meet specific financial and medical requirements.

More information

Genetic Testing for Hereditary Cancer Susceptibility Syndromes

Genetic Testing for Hereditary Cancer Susceptibility Syndromes Medical Coverage Policy Genetic Testing for Hereditary Cancer Susceptibility Syndromes Table of Contents Effective Date... 1/15/2018 Next Review Date... 7/15/2018 Coverage Policy Number... 0518 Related

More information

CANCER GENETICS PROVIDER SURVEY

CANCER GENETICS PROVIDER SURVEY Dear Participant, Previously you agreed to participate in an evaluation of an education program we developed for primary care providers on the topic of cancer genetics. This is an IRB-approved, CDCfunded

More information

Information for You and Your Family

Information for You and Your Family Information for You and Your Family What is Prevention? Cancer prevention is action taken to lower the chance of getting cancer. In 2017, more than 1.6 million people will be diagnosed with cancer in the

More information

Hereditary Colorectal Cancer Syndromes Miguel A. Rodriguez-Bigas, MD

Hereditary Colorectal Cancer Syndromes Miguel A. Rodriguez-Bigas, MD Hereditary Colorectal Cancer Syndromes Miguel A. Rodriguez-Bigas, MD Living Beyond Cancer A-Z January 12,2019 Hereditary CRC Syndromes Objectives are to discuss the : Most common Hereditary CRC syndromes

More information

Update from the 2011 symposium: MOH testing criteria

Update from the 2011 symposium: MOH testing criteria Update from the 2011 symposium: MOH testing criteria Melyssa Aronson, MS, (C)CGC Zane Cohen Centre for Digestive Disease May 26, 2017 Criteria Working Group 2011 Symposium Concerns expressed: Last revised

More information

Lynch Syndrome (HNPCC) and MYH-Associated Polyposis (MAP)

Lynch Syndrome (HNPCC) and MYH-Associated Polyposis (MAP) Lynch Syndrome (HNPCC) and MYH-Associated Polyposis (MAP) A Patient s Guide to risk assessment Hereditary Cancer Testing: Is it Right for You? This workbook is designed to help you decide if hereditary

More information

FAMILIAL COLORECTAL CANCER. Lyn Schofield Manager Familial Cancer Registry

FAMILIAL COLORECTAL CANCER. Lyn Schofield Manager Familial Cancer Registry FAMILIAL COLORECTAL CANCER Lyn Schofield Manager Familial Cancer Registry Cancer in WA 2004 4000 3500 ASPR, rate per 100,000 3000 2500 2000 1500 1000 Male incidence Female incidence Male mortality Female

More information

Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer

Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer s on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer Francis M. Giardiello, MD, 1 John I. Allen, 2 Jennifer E. Axilbund,

More information

Genetic Testing for Lynch Syndrome And Other Inherited Colon Cancer Syndromes

Genetic Testing for Lynch Syndrome And Other Inherited Colon Cancer Syndromes Genetic Testing for Lynch Syndrome And Other Inherited Colon Cancer Syndromes Policy Number: Original Effective Date: MM.02.007 09/01/2011 Line(s) of Business: Current Effective Date: HMO; PPO; QUEST Integration

More information

Clinical Policy Title: Genetic testing for hereditary cancer susceptibility

Clinical Policy Title: Genetic testing for hereditary cancer susceptibility Clinical Policy Title: Genetic testing for hereditary cancer susceptibility Clinical Policy Number: 02.01.19 Effective Date: July 1, 2016 Initial Review Date: May 18, 2016 Most Recent Review Date: May

More information

Serrated Polyps and a Classification of Colorectal Cancer

Serrated Polyps and a Classification of Colorectal Cancer Serrated Polyps and a Classification of Colorectal Cancer Ian Chandler June 2011 Structure Serrated polyps and cancer Molecular biology The Jass classification The familiar but oversimplified Vogelsteingram

More information

Primary Care Approach to Genetic Cancer Syndromes

Primary Care Approach to Genetic Cancer Syndromes Primary Care Approach to Genetic Cancer Syndromes Jason M. Goldman, MD, FACP FAU School of Medicine Syndromes Hereditary Breast and Ovarian Cancer (HBOC) Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

More information

Chapter 18 Section 13

Chapter 18 Section 13 Demonstrations Chapter 18 Section 13 TRICARE Evaluation Of Centers For Medicare And Medicaid Services (CMS) Approved Laboratory Developed Tests (LDTs) Demonstration Project 1.0 PURPOSE The purpose of the

More information

Genetic Risk Assessment for Cancer

Genetic Risk Assessment for Cancer Genetic Risk Assessment for Cancer Jennifer Siettmann, MS CGC Certified Genetic Counselor Banner MD Anderson Cancer Center Objectives Describe the role of genetic counseling and genetic testing in patient

More information

BowelGene. How do I know if I am at risk? Families with hereditary bowel cancer generally show one or more of the following clues:

BowelGene. How do I know if I am at risk? Families with hereditary bowel cancer generally show one or more of the following clues: BowelGene BowelGene What is hereditary bowel cancer? Bowel cancer (also known as colorectal cancer) is the fourth most common cancer in the UK. Unfortunately 1 in 19 women and 1 in 14 men will develop

More information

Genetic Testing for Familial Gastrointestinal Cancer Syndromes. C. Richard Boland, MD La Jolla, CA January 21, 2017

Genetic Testing for Familial Gastrointestinal Cancer Syndromes. C. Richard Boland, MD La Jolla, CA January 21, 2017 Genetic Testing for Familial Gastrointestinal Cancer Syndromes C. Richard Boland, MD La Jolla, CA January 21, 2017 Disclosure Information C. Richard Boland, MD I have no financial relationships to disclose.

More information

Proactive Patient Paves the Way for Genetic Testing of Eight Family Members

Proactive Patient Paves the Way for Genetic Testing of Eight Family Members CASE STUDY Proactive Patient Paves the Way for Genetic Testing of Eight Family Members Quick Summary Samar Mohite * was diagnosed with colon adenocarcinoma at the age of 49 years. Genetic counselling was

More information

NGS for Cancer Predisposition

NGS for Cancer Predisposition NGS for Cancer Predisposition Colin Pritchard MD, PhD University of Washington Dept. of Lab Medicine AMP Companion Society Meeting USCAP Boston March 22, 2015 Disclosures I am an employee of the University

More information

GHUK BowelGene_2017.qxp_Layout 1 22/02/ :22 Page 3 BowelGene

GHUK BowelGene_2017.qxp_Layout 1 22/02/ :22 Page 3 BowelGene GHUK BowelGene_2017.qxp_Layout 1 22/02/2017 10:22 Page 3 BowelGene BowelGene What is hereditary bowel cancer? Bowel cancer (also known as colorectal cancer) is the fourth most common cancer in the UK.

More information

A guide to genetic testing for hereditary cancers

A guide to genetic testing for hereditary cancers Cancer Testing Solutions A guide to genetic testing for hereditary cancers The benefit of knowing TM Hereditary cancer genetic testing can play a critical role in managing health Cancer touches millions

More information

A Patient s Guide to risk assessment. Hereditary Colorectal Cancer

A Patient s Guide to risk assessment. Hereditary Colorectal Cancer A Patient s Guide to risk assessment Hereditary Colorectal Cancer Hereditary Cancer Testing: Is it Right for You? Overview of Syndromes This workbook is designed to help you decide if hereditary cancer

More information

August 7, Dear Ms. Verma: RE: 2018 Preliminary Gapfill Payment Determinations for CY2019. Dear Ms. Verma:

August 7, Dear Ms. Verma: RE: 2018 Preliminary Gapfill Payment Determinations for CY2019. Dear Ms. Verma: ASSOCIATION FOR MOLECULAR PATHOLOGY Education. Innovation & Improved Patient Care. Advocacy. 9650 Rockville Pike. Bethesda, Maryland 20814 Tel: 301-634-7939 Fax: 301-634-7995 amp@amp.org www.amp.org August

More information

Genetic Testing for Inherited Susceptibility to Colon Cancer

Genetic Testing for Inherited Susceptibility to Colon Cancer Medical Policy Manual Genetic Testing, Policy No. 06 Genetic Testing for Inherited Susceptibility to Colon Cancer Next Review: November 2018 Last Review: November 2017 Effective: January 1, 2018 IMPORTANT

More information

Medical Policy Update

Medical Policy Update Medical Policy Update Summer 2017 Highlights of recent medical policy revisions as well as any new medical policies approved by Prevea360 Health Plan s Medical Policy Committee are shown below. The Medical

More information

Guidelines for the assessment of mismatch repair (MMR) status in Colorectal Cancer

Guidelines for the assessment of mismatch repair (MMR) status in Colorectal Cancer Guidelines for the assessment of mismatch repair (MMR) status in Colorectal Cancer Start date: May 2015 Review date: April 2018 1 Background Mismatch repair (MMR) deficiency is seen in approximately 15%

More information

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes MEDICAL POLICY 12.04.506 Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes BCBSA Ref. Policy: 2.04.08 Effective Date: Dec. 1, 2017 Last Revised: Nov. 9, 2017 Replaces: N/A RELATED

More information

Objectives. Genetics in Cancer Treatment and Prevention. Genes

Objectives. Genetics in Cancer Treatment and Prevention. Genes Objectives Genetics in Cancer Treatment and Prevention Cheryl LaFlore, ARNP, MSN, BC Understand how to integrate genetic and genomic information into oncology nursing practice Define the role of an oncology

More information

Genetic Testing for Lynch Syndrome and Inherited Intestinal Polyposis Syndromes

Genetic Testing for Lynch Syndrome and Inherited Intestinal Polyposis Syndromes Genetic Testing for Lynch Syndrome and Inherited Intestinal Polyposis Syndromes Policy Number: 2.04.08 Last Review: 1/2014 Origination: 1/2004 Next Review: 1/2015 Policy Blue Cross and Blue Shield of Kansas

More information

COLORECTAL PATHWAY GROUP, MANCHESTER CANCER. Guidelines for the assessment of mismatch. Colorectal Cancer

COLORECTAL PATHWAY GROUP, MANCHESTER CANCER. Guidelines for the assessment of mismatch. Colorectal Cancer COLORECTAL PATHWAY GROUP, MANCHESTER CANCER Guidelines for the assessment of mismatch repair (MMR) status in Colorectal Cancer March 2017 1 Background Mismatch repair (MMR) deficiency is seen in approximately

More information

Genetic Testing for Inherited Conditions

Genetic Testing for Inherited Conditions Genetic Testing for Inherited Conditions Policy Number: 2018-101 Effective Date: January 26, 2018 Review Date: January 26, 2018 Next Review Date: January 26, 2019 Important Information - Please Read Before

More information

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes

Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Genetic Testing for Lynch Syndrome and Other Inherited Colon Cancer Syndromes Applies to all products administered or underwritten by Blue Cross and Blue Shield of Louisiana and its subsidiary, HMO Louisiana,

More information

Genetic Testing for Inherited Susceptibility to Colon Cancer; Including Microsatellite Instability Testing. Original Policy Date

Genetic Testing for Inherited Susceptibility to Colon Cancer; Including Microsatellite Instability Testing. Original Policy Date MP 2.04.06 Genetic Testing for Inherited Susceptibility to Colon Cancer; Including Microsatellite Instability Testing Medical Policy Section Medicine Issue 12:2013 Original Policy Date 12:2013 Last Review

More information

Understanding Your Positive Result. A guide to understanding your risk and taking action

Understanding Your Positive Result. A guide to understanding your risk and taking action Understanding Your Positive Result A guide to understanding your risk and taking action 2017 Myriad Genetics, Inc. 320 Wakara Way, Salt Lake City, Utah 84108 PH: 1-800-469-7423 FX: 801-584-3615 1 PART

More information

Carol Christianson, MS, CGC Genetic Counselor West Michigan Cancer Center

Carol Christianson, MS, CGC Genetic Counselor West Michigan Cancer Center Carol Christianson, MS, CGC Genetic Counselor West Michigan Cancer Center Following this presentation you will be able to: Identify cancer survivors in your practice who might benefit from genetic counseling

More information

Calendar Year (CY) 2017 Clinical Laboratory Fee Schedule (CLFS) Final Determinations

Calendar Year (CY) 2017 Clinical Laboratory Fee Schedule (CLFS) Final Determinations Calendar Year (CY) 2017 Clinical Laboratory Fee Schedule (CLFS) Final Determinations A. Reconsidered Tests For 2016, CMS implemented four new HCPCS G codes for definitive drug testing: G0480 (Drug test(s),

More information

Germline Testing for Hereditary Cancer with Multigene Panel

Germline Testing for Hereditary Cancer with Multigene Panel Germline Testing for Hereditary Cancer with Multigene Panel Po-Han Lin, MD Department of Medical Genetics National Taiwan University Hospital 2017-04-20 Disclosure No relevant financial relationships with

More information

Hereditary GI tumor syndromes ACG guidelines of genetic testing and management. Dr. med. Henrik Csaba Horváth PhD

Hereditary GI tumor syndromes ACG guidelines of genetic testing and management. Dr. med. Henrik Csaba Horváth PhD Hereditary GI tumor syndromes ACG guidelines of genetic testing and management Dr. med. Henrik Csaba Horváth PhD Genetic testing and management of hereditary GI tumor syndromes June 29, 2016 2 Clinical

More information

Genetic Testing for Heredity Cancer Susceptibility

Genetic Testing for Heredity Cancer Susceptibility Clinical Appropriateness Guidelines Genetic Testing for Heredity Cancer Susceptibility EFFECTIVE OCTOBER 14, 2017 Appropriate.Safe.Affordable 2017 AIM Specialty Health 2064-1017 Table of Contents Scope...

More information