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2 Course Title Form Hours subject Types, and structure of chromosomes L 1 Histology Karyotyping and staining of human chromosomes L 2 Histology Chromosomal anomalies L 2 Histology Sex chromosomes L 1 Histology Mitosis L 1 Histology Meiosis L 1 Histology Nucleotide chemistry L 1 Biochemistry nucleotide function L 1 Biochemistry Degradation of Purine Nucleotides. L 1 Biochemistry Degradation of Pyrimidine Nucleotides. L 1 Biochemistry Diseases related to purine and pyrimidine degradation L 1 Biochemistry Structure of DNA L 1 Biochemistry Steps in Prokaryotic DNA Synthesis L 1 Biochemistry Organization of Eukaryotic DNA L 1 Biochemistry DNA mutation L 1 Biochemistry DNA Repair L 1 Biochemistry Structure of RNA L 1 Biochemistry Transcription of Prokaryotic Genes. L 1 Biochemistry Transcription of Eukaryotic Genes. L 1 Biochemistry Post-Transcriptional Modification of RNA. L 1 Biochemistry The Genetic Code. L 1 Biochemistry Components Required for Translation. L 1 Biochemistry Steps in protein synthesis L 1 Biochemistry Post- translation modifications L 1 Biochemistry Restriction endo-nucleases L 1 Biochemistry DNA probes L 1 Biochemistry Nucleic acid extraction and Polymorphism L 1 Biochemistry Southern blot analysis L 1 Biochemistry Polymerase chain reaction L 1 Biochemistry DNA cloning L 1 Biochemistry

3 Course Title Form Hours subject Bacterial genetics : 1. Mutation L 1 Microbiology Transfer of DNA between bacterial cells L 1 Microbiology Recombination L 1 Microbiology Bacteriophage L 1 Microbiology Bacterial plasmids L 1 Microbiology Types, causes, and mechanism of Chromosomal abnormalities L 1 Anatomy Genetic investigations,cytogenetics L 1 Anatomy Dermatoglyphics, Pedgree chart L 1 Anatomy Oncogenes, tumor suppressor genes L 1 Pathology Regulation of cell cycles L 1 Pathology Molecular basis of carcinogenesis L 1 Pathology Mutation of mismatch repair genes L 1 Pathology Mode of inheritance of different familial tumors L 1 Pathology Hereditary predisposition of cancer in families L 1 Pathology Classification of common types of familial cancers L 1 Pathology Molecular techniques used in diagnosis of parasitic infections L 1 Parasitology Molecular basis of drug resistance in Malaria L 1 Parasitology Genes encoding Malarial and Trypanosomal variant antigens. L 1 Parasitology Strain differentiation in Leishmania L 1 Parasitology Drugs prepared by DNA recombinant technology L 1 pharmacology Gene therapy L 1 pharmacology

4 Objectives of Module of Molecular Biology At the end of this course the student should be able to: Recognize the types, and the structure of chromosomes Practice karyotyping and staining of chromosomes Identify chromosomal anomalies Describe sex chromosomes Discuss mitotic, meiotic division of the cell Memorize nucleotide chemistry Identify degradation of pyrimidine and purine nucleotides Explain disease related to purine, and pyrimidine degradation Describe DNA structure Discuss steps of prokaryotic and eukaryotic replication and organization of DNA Explain DNA mutation and repair Describe Structure of RNA Discuss Transcription of euokaryotic and prokaryotic genes Explain posttranscriptional modification of RNA Define the genetic code Memorize the components required for translation Report steps in protein synthesis Describe posttranslational modification Identify restriction endonucleases, DNA probes Recognize nucleic acid extraction, southern blot analysis Explain nucleic endonuclease fragment polymorphism Discuss polymerase chain reaction Describe DNA cloning

5 Identify bacterial genetics, including mutation, transfer of DNA between bacterial cells and recombination Recognize bacteriophage and bacterial plasmids Describe types, causes, and mechanism of chromosomal abnormalities Discuss genetic investigations and cytogenetics Report dermatographics and pedigree chart Define and classify oncogenes and tumor suppressor gene Describe the regulation of cell cycle Discuss the molecular basis of carcinogenesis Explain mutation of mismatch repair Identify mode of inheritance of different familiar tumors Recognize hereditary predisposition of cancer in families Classify common types of familial carcinomas Explain molecular techniques used in diagnosis of (Malaria- Toxoplasma Filaria). Discuss the molecular basis of drug resistance to Malaria plasmodia. PCR used in strain differentiation of Leishmania. Describe drugs prepared by DNA recombinant technology Review gene therapy Identify the molecular basis of drug action