Targeted Chemoprevention of Progressive Marrow Failure in Patients with Fanconi Anemia using Quercetin, a Pilot study

Size: px
Start display at page:

Download "Targeted Chemoprevention of Progressive Marrow Failure in Patients with Fanconi Anemia using Quercetin, a Pilot study"

Transcription

1 Targeted Chemoprevention of Progressive Marrow Failure in Patients with Fanconi Anemia using Quercetin, a Pilot study Parinda Mehta, M.D. Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children s Hospital Medical Center

2 Treatment options for Fanconi Anemia Diagnosis Early marrow failure Moderate marrow failure End-stage Marrow failure Comprehensive Care Clinic Complementation Watchful waiting Newer Androgens Radiation-free Hematopoietic Transplantation Need for an effective novel therapy with a better toxicity profile

3

4 Reactive Oxygen Species (ROS) in FA Studies in both animals and human subjects indicate that high levels of and increased sensitivity to ROS plays an important role in pathogenesis of bone marrow failure in patients with FA

5 ROS

6 Reactive oxygen species (ROS) Reactive oxygen species (ROS) refer to a variety of molecules and free radicals derived from molecular oxygen The biologically relevant ROS, such as hydrogen peroxide (H2O2), superoxide (O2), and the hydroxyl radical (HO), are generated from the precursor superoxide anion

7

8 Consequences of increased oxidative stress/ros Oxidative stress is detrimental to cells due to oxidative damage to lipids, proteins, and DNA This leads to a cascade of events that leads to apoptosis (cell death) or uncontrolled proliferation

9 Consequences of increased oxidative stress/ros Marrow Failure MDS/Leukemia/ other cancers

10 What can we do about this?

11 Quercetin (antioxidant) reduces TNFgenerated ROS Normal Control FA-A

12 Quercetin prevents marrow failure and leukemia in Fanconi mice Quercetin improves stem cell compartment increases cells that make blood cells in mice with FA Cells from Fanconi mice do not turn into leukemia after treatment with Quercetin

13 Mice with Fanconi anemia have prediabetes (similar to children with FA) quercetin also makes this better

14 So, what happens in patients? Patients with FA produce increased ROS levels compared to normal controls ROS levels decrease to baseline with addition of Quercetin in in-vitro studies, using both BM and peripheral blood samples from patients with FA

15 Reversal of ROS with Quercetin in patients with FA

16 Quercetin in FA patients These data suggest a possible benefit in supporting hematopoiesis and preventing progressive marrow failure with Quercetin

17 What is Quercetin? Quercetin (3, 30, 40, 5, 7- pentahydroxyflavone) is a naturally occurring flavonoid Richest dietary sources include onions, apples, berries, tea and red wine Common ingredient in dietary supplements and multivitamin preparations

18 Quercetin Has a wide range of biological activities - free radical scavenging - iron chelating - anti-inflammation - antioxidant - antineoplastic properties

19 ROS suppression and marrow failure/mds/aml in FA

20 Clinical Implications Reversal of marrow failure will obviate or delay the need for stem cell transplantation If found to be effective, treatment with Quercetin can be included in standard clinical care of this patient population for many years

21 Clinical trial of Quercetin in patients with FA In adult studies oral Quercetin has been well tolerated without any side effects Our study of Quercetin in patients with FA is now open and enrolling!

22 Clinical trial of Quercetin in Three goals: patients with FA 1. Establish safety 2. Establish feasibility of long term administration 3. Obtain pharmacokinetic data/drug level meaning how the drug is handled by patients with FA

23 Quercetin in FA This study will enroll 12 patients in different stages of marrow failure Inclusion Criteria - Diagnosis of FA proven by DEB test - Able to take enteral medication Major Exclusion Criteria - Patients with morphological evidence of MDS or leukemia

24 Quercetin Administration Quercetin will be supplied as a liquid suspension, to be taken twice a day Patients will be treated with Quercetin twice a day for 4 months

25 Monitoring for safety and feasibility of Quercetin in FA patients Patients will be monitored closely for any side effects Weekly phone calls from study co-ordinator Pre-treatment testing, regular blood tests Follow up visit with bone marrow testing at 4 months and again at 1 year

26 Monitoring for Quercetin effects We will measure levels of Quercetin in the blood to see if we can get optimal levels We will measure ROS levels in blood and bone marrow to see if it is in fact decreasing after Quercetin We will also follow blood counts, growth and blood sugars closely to see the effects of the supplement

27 Progress on the study First three patients (>12 years of age) are enrolled! Tolerating Quercetin very well No major side effects We are seeing improvement in the colony count of baby blood cells.

28 AUC is better, the peak glucose is not as high, and there is no hypoglycemia at the end of the test

29 Quercetin suppresses tumor growth in mice ** *

30 What do we expect? Our pilot study will show that long term oral Quercetin therapy is feasible, safe and can achieve biologically relevant blood levels in patients with FA These results will form the basis of our next efficacy study, which will demonstrate that Quercetin therapy delays or prevents progressive marrow failure in children with FA Assess safety, feasibility and pharmacokinetics (PK) of oral Quercetin therapy in pediatric patients with FA Role of Quercetin therapy in patients with Fanconi Anemia Prevention of progressive marrow failure in FA Efficacy in improving hematopoiesis To assess efficacy of Quercetin in improving hematopoiesis (i.e. peripheral counts) and insulin sensitivity/glucose tolerance Measure the impact of Quercetin on reduction of ROS, and maintenance or improvement of hematopoietic stem cell (HSC) reserve

31 Thank You

Lay Summaries ASH 2017

Lay Summaries ASH 2017 Lay Summaries ASH 2017 Purpose of Document: This document contains a collection of lay summaries of accepted ASH 2017 abstracts from the following investigators: MDS CRC Members/Affiliates, Fellows (past

More information

Reactive Oxygen species ROS + Anti-oxidants. Dr. Naif Karadsheh

Reactive Oxygen species ROS + Anti-oxidants. Dr. Naif Karadsheh Reactive Oxygen species ROS + Anti-oxidants Dr. Naif Karadsheh Oxygen Toxicity & Free Radicals Biradical O 2 Radical O 2 Non-Radical Radical H 2 O 2 OH ROS O 2 Metabolism and Toxicity O 2 Consumption >90%

More information

Metabolism of xenobiotics FM CHE 5-6

Metabolism of xenobiotics FM CHE 5-6 Metabolism of xenobiotics FM 3.5-10 CHE 5-6 Metabolism of xenobiotics Also called:! Biotransformation, or detoxification Primary metabolism secondary metabolism Goal: To make use of a compound or to facilitate

More information

number Done by Corrected by Doctor

number Done by Corrected by Doctor number 19 Done by حسام ابو عوض Corrected by وسيم ابو عبيدة Doctor د.نايف 1 P a g e GAGs and Glycoproteins: GAGs: long, unbranched heteropolysaccharides, made from زunits repeating disaccharide [Acidic

More information

OSAS oxidative stress and atherosclerosis Who is the culprit: AHI or ODI

OSAS oxidative stress and atherosclerosis Who is the culprit: AHI or ODI OSAS oxidative stress and atherosclerosis Who is the culprit: AHI or ODI Arie Wollner MD, FCCP Department of Respiratory Care and Rehabilitation Sheba Medical Center OSA as a major public health problem

More information

Lujain Hamdan. Faisal Nimri

Lujain Hamdan. Faisal Nimri 20 Lujain Hamdan Faisal Nimri...... Sources of NADPH [ The pentose phosphate pathway is the primary source of the NADPH and is the only source in RBC.] Cytosolic conversion of oxaloacetate to pyruvate

More information

Blood 101 Introduction Blood and Marrow & Overview of Bone Marrow Failure Diseases. Dr. M. Sabloff October 16 th 2010

Blood 101 Introduction Blood and Marrow & Overview of Bone Marrow Failure Diseases. Dr. M. Sabloff October 16 th 2010 Blood 101 Introduction Blood and Marrow & Overview of Bone Marrow Failure Diseases Dr. M. Sabloff October 16 th 2010 Normal Marrow knee joint white is articular cartilage Adjacent to this is the red marrow

More information

NFκB What is it and What s the deal with radicals?

NFκB What is it and What s the deal with radicals? The Virtual Free Radical School NFκB What is it and What s the deal with radicals? Emily Ho, Ph.D Linus Pauling Institute Scientist Department of Nutrition and Food Management Oregon State University 117

More information

Subject Index. rationale for supplementation in cancer patients 260, 273 surgical cancer patient supplementation

Subject Index. rationale for supplementation in cancer patients 260, 273 surgical cancer patient supplementation Acute-phase response, cytokine mediation in cachexia 157, 158 ß 2 -Adrenergic agonist, effects on rat tumor models 264 Alcohol breast cancer studies 107, 108, 111, 112, 116 ß-carotene interactions 53 lung

More information

Inhaled Formaldehyde Induces Bone Marrow Toxicity via Oxidative Stress in Exposed Mice

Inhaled Formaldehyde Induces Bone Marrow Toxicity via Oxidative Stress in Exposed Mice DOI:http://dx.doi.org/1.731/APJCP.1.1.13.3 RESEARCH ARTICLE Inhaled Formaldehyde Induces Bone Marrow Toxicity via Oxidative Stress in Exposed Mice Guang-Yan Yu 1, Xiang-Fu Song 1, Ying Liu 1, Zhi-Wei Sun

More information

State of the art ingredients fast friendly service

State of the art ingredients fast friendly service ALPHA-LIPOIC ACID An Efficient Antioxidant α-lipoic acid also known as thioctic acid, plays an important role in metabolic processes. It functions as a co-factor for a number of key enzymes that help in

More information

Prepared for: Cancer Patients Created by: Guru Mann Label: T- Series Plan: Nutrition Videos & PDF

Prepared for: Cancer Patients Created by: Guru Mann Label: T- Series Plan: Nutrition Videos & PDF F I G H T C A N C E R Prepared for: Cancer Patients Created by: Guru Mann Label: T- Series Plan: Nutrition Videos & PDF ` Guru Mann Fitness Inc. United States . What is Cancer? Cancer is the uncontrolled

More information

TEST REPORT & SPECIFIC INFORMATION

TEST REPORT & SPECIFIC INFORMATION Page 1 (5) Dartsch Scientific GmbHAuf der Voßhardt 25 D-49419 Wagenfeld Firma LuKo Pharm GmbH Mayrwiesstrasse 25-27 A-5300 Hallwang Auf der Voßhardt 25 D-49419 Wagenfeld, Germany Fon: +49 5444 980 1322

More information

Protein Cleavage Due to Pro-oxidative Activity in Some Spices

Protein Cleavage Due to Pro-oxidative Activity in Some Spices Protein Cleavage Due to Pro-oxidative Activity in Some Spices Sittiwat Lertsiri Department of Biotechnology Faculty of Science, Mahidol University Phayathai, Bangkok 10400 Thailand Kanchana Dumri Department

More information

Functional Properties of Cocoa Products: Health Aspects. Puspo Edi Giriwono SEAFAST Center - IPB

Functional Properties of Cocoa Products: Health Aspects. Puspo Edi Giriwono SEAFAST Center - IPB Functional Properties of Cocoa Products: Health Aspects Puspo Edi Giriwono SEAFAST Center - IPB Theobroma cacao Nutrient content of various cocoa products Colombo et al., Chocolate and Health., 2012 Cocoa

More information

- Spontaneous hemorrhaging increase

- Spontaneous hemorrhaging increase MEDCHEM 562-2014 Fat Soluble Vitamins Problem Set 1. Fill out the blanks in the table below. Vitamin Physiological Function Deficiency symptoms Toxicity A -Vision -Cell Differentiation -Inhibition of Cell

More information

Suggested homework problems: 8.8, 8.13, ,

Suggested homework problems: 8.8, 8.13, , Chapter 8 Outline: Haloalakanes, Halogenation, & Radical reactions Cover 8.1-8.3 on your own 1. Halogenation of Alkanes A. Mechanism of Halogenation B. Regioselectivity & Stereoselectivity of Halogenation

More information

SKINFLAMM-AGING. pollution UVB/UVA. free radicals. immune cells. damage signals. antioxidants

SKINFLAMM-AGING. pollution UVB/UVA. free radicals. immune cells. damage signals. antioxidants RESTORE YOUTHFUL SKIN Inflammation is becoming a mainstream concept for consumers Aging skin is inflamed skin and the easiest way to reverse the aging process is through controlling inflammation with anti-oxidants

More information

CONTRACTING ORGANIZATION: Oregon Health & Science University Portland OR 97239

CONTRACTING ORGANIZATION: Oregon Health & Science University Portland OR 97239 AWARD NUMBER: W81XWH-16-1-0300 TITLE: Metformin Therapy for Fanconis Anemia PRINCIPAL INVESTIGATOR: Markus Grompe CONTRACTING ORGANIZATION: Oregon Health & Science University Portland OR 97239 REPORT DATE:

More information

Aging and nutrition 03/11/2012. Why do people age? Oxidative stress and damage

Aging and nutrition 03/11/2012. Why do people age? Oxidative stress and damage Aging and nutrition % of elderly people in Canadian population is increasing more than for other age groups within the elderly age group there is great variability in terms health, metabolism, physical

More information

Summary of the publication cycle entitled: I.-III III

Summary of the publication cycle entitled: I.-III III Summary of the publication cycle entitled: Interactions of bioactive ingredients of coffee and selected functional supplements as factor modifying their potential biological activity" Consumption of foods

More information

Summary & conclusion

Summary & conclusion Summary & conclusion Cancer is the prime cause of death in developed countries and the second major cause of death in developing world. The early diagnosis is very crucial for the effective treatment of

More information

Recently Researched Effects of Individual Nutrients

Recently Researched Effects of Individual Nutrients Recently Researched Effects of Individual Nutrients Alpha Lineoleic Acid (Omega 3) 1 ensures the optimal cerebral and cognitive development of the infant the presence of large quantities of EPA and DHA

More information

Speaker: Paul De Smet. Thursday June 4th 2015

Speaker: Paul De Smet. Thursday June 4th 2015 Speaker: Paul De Smet Thursday June 4th 2015 Your logo Stress Support: the nutritional answer to stress, infection and disease Thursday June 4th 2015 Table of content Stress Support: the nutritional answer

More information

By Soha Mohamed Hamdy (1),Abdelkarim Mohamed Abdellatif (2) and Rania Mortada Mahmuod (1)

By Soha Mohamed Hamdy (1),Abdelkarim Mohamed Abdellatif (2) and Rania Mortada Mahmuod (1) BIOCHEMICAL STUDIES ON THE EFFECT OF TURMERIC ON BREAST CANCER OF RATS By Soha Mohamed Hamdy (1),Abdelkarim Mohamed Abdellatif (2) and Rania Mortada Mahmuod (1) 1) Biochemistry Div. Chemistry Dep. Faculty

More information

number Done by Corrected by Doctor Nayef Karadsheh

number Done by Corrected by Doctor Nayef Karadsheh number 17 Done by Abdulrahman Alhanbali Corrected by Lara Abdallat Doctor Nayef Karadsheh 1 P a g e Pentose Phosphate Pathway (PPP) Or Hexose Monophosphate Shunt In this lecture We will talk about the

More information

Gastroenterology and Feeding Issues in Fanconi Anemia

Gastroenterology and Feeding Issues in Fanconi Anemia Gastroenterology and Feeding Issues in Fanconi Anemia Sarah Jane Schwarzenberg, MD Pediatric Gastroenterology, Hepatology and Nutrition August 12, 2012 GI problems in FA 5% have gastrointestinal tract

More information

Vitamin C and Joint Disease. Eva Star FCS 308

Vitamin C and Joint Disease. Eva Star FCS 308 Vitamin C and Joint Disease Eva Star FCS 308 Fall, 2009 Vitamin C and Joint Disease Joint disease affects numerous people around the world. Osteoarthritis is one type of join disease which affects joints

More information

Instructor s Manual for Unit 2 The Inside Story about Nutrition and Health

Instructor s Manual for Unit 2 The Inside Story about Nutrition and Health Instructor s Manual for Unit 2 The Inside Story about Nutrition and Health Class Preparation Materials in the Instructor s Manual for Unit 2 Learning Objectives Brief Chapter Outline Answers to Global

More information

Hematopoiesis. - Process of generation of mature blood cells. - Daily turnover of blood cells (70 kg human)

Hematopoiesis. - Process of generation of mature blood cells. - Daily turnover of blood cells (70 kg human) Hematopoiesis - Process of generation of mature blood cells - Daily turnover of blood cells (70 kg human) 1,000,000,000,000 total cells 200,000,000,000 red blood cells 70,000,000,000 neutrophils Hematopoiesis

More information

Table 1: Synthesis of clinical trials with resveratrol and cancer presented in the site of (accessed in April 2017).

Table 1: Synthesis of clinical trials with resveratrol and cancer presented in the site of  (accessed in April 2017). Table 1: Synthesis of clinical trials with resveratrol and cancer presented in the site of www.clinicaltrials.gov (accessed in April 2017). Clinical Trials.gov identifier Number/ Year of inclusion Status

More information

Faculty of Medicine Dr. Tariq Aladily

Faculty of Medicine Dr. Tariq Aladily Iron deficiency anemia The most common anemia worldwide Only 10% of ingested iron is absorbed Most dietary iron occurs in meat products Absorbed in duodenum Hepcidin By inhibiting ferroportin, hepcidin

More information

Chemical and Biochemical Mechanism Of Cell Injury.

Chemical and Biochemical Mechanism Of Cell Injury. Chemical and Biochemical Mechanism Of Cell Injury. Professor Dr. M. Tariq Javed Dept. of Pathology Faculty of Vet. Science The University Of Agriculture Faisalabad Cell Injury When the cell is exposed

More information

Dietary supplementation in treating non-alcoholic fatty liver disease Dr. Ahmad Saedi Associate Professor School of Nutritional Sciences and

Dietary supplementation in treating non-alcoholic fatty liver disease Dr. Ahmad Saedi Associate Professor School of Nutritional Sciences and Dietary supplementation in treating non-alcoholic fatty liver disease Dr. Ahmad Saedi Associate Professor School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Honorary Academic

More information

Research Papers Title Conference, Collaborators Year

Research Papers Title Conference, Collaborators Year Research Papers - Title Conference, Collaborators Year Redox regulation by model for electrolyzed-reduced functional Ayumi Hosokawa et.al. Analysis of nano particle on biological availability and toxicity

More information

Lecture 19 Summary Gestational Diabetes and Complications of Diabetes. Gestational diabetes;

Lecture 19 Summary Gestational Diabetes and Complications of Diabetes. Gestational diabetes; Lecture 19 Summary Gestational Diabetes and Complications of Diabetes Gestational diabetes; - Type of diabetes that only develops during pregnancy Usually diagnosed in late pregnancy Causes high blood

More information

EM-X Herbal Tea Inhibits Interleukin-8 Release in Alvelor Epithelial cells

EM-X Herbal Tea Inhibits Interleukin-8 Release in Alvelor Epithelial cells EM-X Herbal Tea Inhibits Interleukin-8 Release in Alvelor Epithelial cells Okezie I. Arouma a) and Irfan Rahman b) a) Department of Neuroinflammation, Division of Neuroscience & Psychological Medicine,

More information

Mechanistic Toxicology

Mechanistic Toxicology SECOND EDITION Mechanistic Toxicology The Molecular Basis of How Chemicals Disrupt Biological Targets URS A. BOELSTERLI CRC Press Tavlor & France Croup CRC Press is an imp^t o* :H Taylor H Francn C'r,,jpi

More information

SUMMARY AND CONCLUSION

SUMMARY AND CONCLUSION SUMMARY AND CONCLUSION 7. SUMMARY AND CONCLUSION Oxidative stress has been repetitively hallmarks of many diseases linked with metabolic or vascular disorders. Diabetes mellitus is the most rapidly growing

More information

Lipid Oxidation and its Implications to Food Quality and Human Health. Dong Uk Ahn Animal Science Department Iowa State University

Lipid Oxidation and its Implications to Food Quality and Human Health. Dong Uk Ahn Animal Science Department Iowa State University Lipid Oxidation and its Implications to Food Quality and Human Health Dong Uk Ahn Animal Science Department Iowa State University Introduction Process of Lipid Oxidation Free Radicals and Reactive Oxygen

More information

Lipid Oxidation in Muscle Foods

Lipid Oxidation in Muscle Foods Lipid Oxidation in Muscle Foods Unique Challenges with Oxidation in Muscle Foods Rancidity is a major shelf-life limiting factor in frozen muscle foods NaCl generally accelerates oxidation Oxidation accelerates

More information

About Fermented Guava

About Fermented Guava About Fermented Guava The Fermented Guava was developed through the joint studies by the following research institutes, including Okinawa Industrial Technology Center, as part of the Okinawa R&D coordinating

More information

Hormones and Homeostasis

Hormones and Homeostasis Hormones and Homeostasis The endocrine system is a system of organs that releases chemical message molecules, called hormones, into the blood. Unlike the nervous system whose action helps the body react

More information

Assoc. Prof. Dr. Aslı Korkmaz* and Prof. Dr. Dürdane Kolankaya**

Assoc. Prof. Dr. Aslı Korkmaz* and Prof. Dr. Dürdane Kolankaya** The possible protective effects of some flavonoids that found honey by experimental ischemia/reperfusion (I/R) induced nitrosative damage in kidney of male rats Assoc. Prof. Dr. Aslı Korkmaz* and Prof.

More information

Myelodysplastic Syndrome: Let s build a definition

Myelodysplastic Syndrome: Let s build a definition 1 MDS: Diagnosis and Treatment Update Gail J. Roboz, M.D. Director, Leukemia Program Associate Professor of Medicine Weill Medical College of Cornell University The New York Presbyterian Hospital Myelodysplastic

More information

Arthritis is a very common medical condition estimated to affect around. seven million people in the UK. However, it is not a single disease but comes

Arthritis is a very common medical condition estimated to affect around. seven million people in the UK. However, it is not a single disease but comes Chapter 6: Antiarthritic activity of cultured mycelium of Volvariella volvacea 6.1. Introduction Arthritis is a very common medical condition estimated to affect around seven million people in the UK.

More information

LifePak Health Benefits. LifePak is optimum supplementation for:

LifePak Health Benefits. LifePak is optimum supplementation for: LifePak What is LifePak? Our comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being. LifePak Health

More information

Mid Term Test- Template Questions

Mid Term Test- Template Questions Mid Term Test- Template Questions Name : ID : Time: Date: Total points: 100 Instructions: 1. Only 20 questions from Section I and II, 10 questions from Section III will be counted for grading. 2. Try to

More information

Hematopoiesis. Hematopoiesis. Hematopoiesis

Hematopoiesis. Hematopoiesis. Hematopoiesis Chapter. Cells and Organs of the Immune System Hematopoiesis Hematopoiesis- formation and development of WBC and RBC bone marrow. Hematopoietic stem cell- give rise to any blood cells (constant number,

More information

Nothing Compares to Fiji Achievers 2012

Nothing Compares to Fiji Achievers 2012 Nothing Compares to Fiji Achievers 2012 HEALTH & WELLNESS Nature Organic farms Natural ingredients Best of Nature. Best of Science Science NHI Seed to supplement Research Affiliations Nutrilite Experience

More information

Supplements That Best Support Your Exercise Routine

Supplements That Best Support Your Exercise Routine Supplements That Best Support Your Exercise Routine We are closing in on a new year, a time when many people embark on resolutions which include changes to lifestyle such as diet and exercise. If you want

More information

Supplementary Figure 1

Supplementary Figure 1 Supplementary Figure 1 Expression of apoptosis-related genes in tumor T reg cells. (a) Identification of FOXP3 T reg cells by FACS. CD45 + cells were gated as enriched lymphoid cell populations with low-granularity.

More information

Real-time PK Measurement of the Chemotherapeutic Drug Melphalan in Whole Blood by a Novel PaperSpray Mass Spectrometry

Real-time PK Measurement of the Chemotherapeutic Drug Melphalan in Whole Blood by a Novel PaperSpray Mass Spectrometry Palm Springs, California February 21-25 Real-time PK Measurement of the Chemotherapeutic Drug Melphalan in Whole Blood by a Novel PaperSpray Mass Spectrometry Junfang Zhao, Chandra Sharat, Parinda A. Mehta,

More information

TDM. Measurement techniques used to determine cyclosporine level include:

TDM. Measurement techniques used to determine cyclosporine level include: TDM Lecture 15: Cyclosporine. Cyclosporine is a cyclic polypeptide medication with immunosuppressant effect. It has the ability to block the production of interleukin-2 and other cytokines by T-lymphocytes.

More information

Production of the Formed Elements (Chapter 11) *

Production of the Formed Elements (Chapter 11) * OpenStax-CNX module: m62120 1 Production of the Formed Elements (Chapter 11) * Ildar Yakhin Based on Production of the Formed Elements by OpenStax This work is produced by OpenStax-CNX and licensed under

More information

Clean Label Solutions to Controlling Lipid Oxidation

Clean Label Solutions to Controlling Lipid Oxidation Clean Label Solutions to Controlling Lipid Oxidation Eric A Decker Department of Food Science University of Massachusetts, Amherst, USA March 27-28, 2018 Itasca, Illinois, USA Why is Oxidation Important?

More information

?Pairing peanuts with other healthy foods can actually help you. Nutrient Density. Peanuts Improve Nutrient Intake %RDA %RDA

?Pairing peanuts with other healthy foods can actually help you. Nutrient Density. Peanuts Improve Nutrient Intake %RDA %RDA Peanuts Improve Nutrient Intake snacking on peanuts improves intake of healthy nutrients. One serving of peanuts provides many of the essential nutrients we need each day. These include vitamin E, magnesium,

More information

AN ACTIVE SHELTER AGAINST POLLUTION V.16

AN ACTIVE SHELTER AGAINST POLLUTION V.16 AN ACTIVE SHELTER AGAINST POLLUTION V.16 THE SKIN IS CONSTANTLY EXPOSED The skin is an interface and thus is constantly exposed to environmental agents: Sun radiation Smoke Air pollution Free radicals

More information

Nutraceuticals & Lifestyle Changes That Can Halt The Progression Of Alzheimer s. by Dr. Gregory Smith

Nutraceuticals & Lifestyle Changes That Can Halt The Progression Of Alzheimer s. by Dr. Gregory Smith Nutraceuticals & Lifestyle Changes That Can Halt The Progression Of Alzheimer s by Dr. Gregory Smith DIET: Studies of dietary influences on Alzheimer's disease do not yet provide clear evidence. Also the

More information

Done By : WESSEN ADNAN BUTHAINAH AL-MASAEED

Done By : WESSEN ADNAN BUTHAINAH AL-MASAEED Done By : WESSEN ADNAN BUTHAINAH AL-MASAEED Acute Myeloid Leukemia Firstly we ll start with this introduction then enter the title of the lecture, so be ready and let s begin by the name of Allah : We

More information

Important reactions of lipids

Important reactions of lipids Taif University College of Medicine Preparatory Year Students Medical chemistry (2) Part II (Lipids) week 4 lectures 1435-36 Important reactions of lipids Lectures outlines Definition and importance of

More information

Sensitivity of mammalian cells to higher concentrations of reactive oxygen species induced by radiation or chemical treatment

Sensitivity of mammalian cells to higher concentrations of reactive oxygen species induced by radiation or chemical treatment Sensitivity of mammalian cells to higher concentrations of reactive oxygen species induced by radiation or chemical treatment The reactive oxygen species (ROS) are group of very unstable compounds that

More information

Aplastic Anemia. is a bone marrow failure disease 9/19/2017. What you need to know about. The 4 major components of blood

Aplastic Anemia. is a bone marrow failure disease 9/19/2017. What you need to know about. The 4 major components of blood What you need to know about Aplastic Anemia Stuart Goldberg MD Aplastic Anemia is a bone marrow failure disease The bone marrow is the factory that makes blood The 4 major components of blood Red Blood

More information

Antioxidant Products

Antioxidant Products Antioxidant Products Introduction Introduction Antioxidant Total Antioxidant Status (TAS) Ransel Ransod Glutathione Reductase Antioxidants help defend living organisms against free radical attack. Many

More information

MDS 101. What is bone marrow? Myelodysplastic Syndrome: Let s build a definition. Dysplastic? Syndrome? 5/22/2014. What does bone marrow do?

MDS 101. What is bone marrow? Myelodysplastic Syndrome: Let s build a definition. Dysplastic? Syndrome? 5/22/2014. What does bone marrow do? 101 May 17, 2014 Myelodysplastic Syndrome: Let s build a definition Myelo bone marrow Gail J. Roboz, M.D. Director, Leukemia Program Associate Professor of Medicine What is bone marrow? What does bone

More information

Aplastic Anemia: Current Thinking

Aplastic Anemia: Current Thinking Aplastic Anemia: Current Thinking ANDREW C. DIETZ, MD, MSCR PEDIATRIC BLOOD AND MARROW TRANSPLANTATION CHILDREN S HOSPITAL LOS ANGELES, UNIVERSITY OF SOUTHERN CALIFORNIA Outline Ø What is Aplastic Anemia?

More information

Overview of Aplastic Anemia. Overview of Aplastic Anemia. Epidemiology of aplastic anemia. Normal hematopoiesis 10/6/2017

Overview of Aplastic Anemia. Overview of Aplastic Anemia. Epidemiology of aplastic anemia. Normal hematopoiesis 10/6/2017 Overview of Aplastic Anemia Overview of Aplastic Anemia Peter Westervelt, MD, PhD Professor of Medicine Chief, BMT/Leukemia Section Washington University School of Medicine Epidemiology Normal hematopoiesis

More information

1Why lipids cannot be transported in blood alone? 2How we transport Fatty acids and steroid hormones?

1Why lipids cannot be transported in blood alone? 2How we transport Fatty acids and steroid hormones? 1Why lipids cannot be transported in blood alone? 2How we transport Fatty acids and steroid hormones? 3How are dietary lipids transported? 4How lipids synthesized in the liver are transported? 5 Lipoprotien

More information

Michael Grimley 1, Vinod Prasad 2, Joanne Kurtzberg 2, Roy Chemaly 3, Thomas Brundage 4, Chad Wilson 4, Herve Mommeja-Marin 4

Michael Grimley 1, Vinod Prasad 2, Joanne Kurtzberg 2, Roy Chemaly 3, Thomas Brundage 4, Chad Wilson 4, Herve Mommeja-Marin 4 Twice-weekly Brincidofovir (BCV, CMX1) Shows Promising Antiviral Activity in Immunocompromised Transplant Patients with Asymptomatic Adenovirus Viremia Michael Grimley 1, Vinod Prasad, Joanne Kurtzberg,

More information

Hematopoietic Stem Cell Transplantation for Fanconi Anemia

Hematopoietic Stem Cell Transplantation for Fanconi Anemia Hematopoietic Stem Cell Transplantation for Fanconi Anemia John E. Wagner, M.D. Blood and Marrow Transplant Program University of Minnesota Cell Therapy for Pediatric Diseases NHLBI PACT Workshop 14 15

More information

Antioxidant Activity of the plant Andrographis paniculata (Invitro)

Antioxidant Activity of the plant Andrographis paniculata (Invitro) Chapter 4 Antioxidant Activity of the plant Andrographis paniculata (Invitro) 4.1 INTRODUCTION Antioxidants prevents or repairs the cells against reactive oxygen species, reduces damage caused by free

More information

The World Health Organization (WHO) has described diabetes mellitus as Metabolic

The World Health Organization (WHO) has described diabetes mellitus as Metabolic 1.1. Background The World Health Organization (WHO) has described diabetes mellitus as Metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate,

More information

NEURO-DEGENERATION CONCEPT

NEURO-DEGENERATION CONCEPT Brain guard. NEURO-DEGENERATION CONCEPT Unique Brain Protection Therapy. New therapy potentials new confidence. Neurodegenerative diseases are defined as a series of diseases that primarily affect the

More information

LONG TERM FOLLOW-UP OF PATIENTS WITH FANCONI ANEMIA AFTER ALLOGENEIC T-CELL DEPLETED HEMATOPOITEIC STEM CELL TRANSPLANTATION FROM ALTERNATIVE DONORS

LONG TERM FOLLOW-UP OF PATIENTS WITH FANCONI ANEMIA AFTER ALLOGENEIC T-CELL DEPLETED HEMATOPOITEIC STEM CELL TRANSPLANTATION FROM ALTERNATIVE DONORS LONG TERM FOLLOW-UP OF PATIENTS WITH FANCONI ANEMIA AFTER ALLOGENEIC T-CELL DEPLETED HEMATOPOITEIC STEM CELL TRANSPLANTATION FROM ALTERNATIVE DONORS Farid Boulad, Susan E Prockop, Praveen Anur, Danielle

More information

Cytokines, adhesion molecules and apoptosis markers. A comprehensive product line for human and veterinary ELISAs

Cytokines, adhesion molecules and apoptosis markers. A comprehensive product line for human and veterinary ELISAs Cytokines, adhesion molecules and apoptosis markers A comprehensive product line for human and veterinary ELISAs IBL International s cytokine product line... is extremely comprehensive. The assays are

More information

ANATOMY OF THE IMMUNE SYSTEM

ANATOMY OF THE IMMUNE SYSTEM Immunity Learning objectives Explain what triggers an immune response and where in the body the immune response occurs. Understand how the immune system handles exogenous and endogenous antigen differently.

More information

CHEMISTRY AND BIOCHEMISTRY OF FOOD

CHEMISTRY AND BIOCHEMISTRY OF FOOD Syllabus CHEMISTRY AND BIOCHEMISTRY OF FOOD - 71430 Last update 26-03-2017 HU Credits: 3 Degree/Cycle: 1st degree (Bachelor) Responsible Department: biochemistry & food sciences Academic year: 0 Semester:

More information

ANTIOXIDANT ACTIVITY OF THE 1,7-DIARYLHEPTANOIDS AND THEIR METAL COMPLEXES

ANTIOXIDANT ACTIVITY OF THE 1,7-DIARYLHEPTANOIDS AND THEIR METAL COMPLEXES ANTIOXIDANT ACTIVITY OF THE 1,7-DIARYLHEPTANOIDS AND THEIR METAL COMPLEXES Malini.P.T Lanthanide complexes of curcuminoids Thesis. Department of Chemistry, University of Calicut, 2004 CHAPTER IV ANTIOXIDANT

More information

CAPROS CHOICE PRODUCT TO HELP IMPROVE CARDIOVASCULAR HEALTH PRODUCT OVERVIEW: CHEMISTRY:

CAPROS CHOICE PRODUCT TO HELP IMPROVE CARDIOVASCULAR HEALTH PRODUCT OVERVIEW: CHEMISTRY: APRS HIE PRDUT T HELP IMPRVE ARDIVASULAR HEALTH PRDUT VERVIEW: apros is a single ingredient derived from edible fruits having properties to support cardiovascular health by improving endothelial function

More information

Pharmacologyonline 2: (2009)

Pharmacologyonline 2: (2009) A TIOXIDA T ACTIVITY OF SOME B COMPLEX VITAMI ES; A PRELIMI ARY STUDY Nabavi S.F., Nabavi S.M., Eslami Sh. and Ebrahimzadeh M.A.* Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran

More information

What Is Oxidative Stress?

What Is Oxidative Stress? Oxidative Stress What Is Oxidative Stress? JMAJ 45(7): 271 276, 2002 Toshikazu YOSHIKAWA* and Yuji NAITO** Professor* and Associate Professor**, First Department of Medicine, Kyoto Prefectural University

More information

2. List routes of exposure in the order of most rapid response.

2. List routes of exposure in the order of most rapid response. Practice Test questions: 1. What are the two areas of toxicology that a regulatory toxicologist must integrate in order to determine the "safety" of any chemical? 2. List routes of exposure in the order

More information

One Day BMT Course by Thai Society of Hematology. Management of Graft Failure and Relapsed Diseases

One Day BMT Course by Thai Society of Hematology. Management of Graft Failure and Relapsed Diseases One Day BMT Course by Thai Society of Hematology Management of Graft Failure and Relapsed Diseases Piya Rujkijyanont, MD Division of Hematology-Oncology Department of Pediatrics Phramongkutklao Hospital

More information

Acute Myeloid Leukemia: A Patient s Perspective

Acute Myeloid Leukemia: A Patient s Perspective Acute Myeloid Leukemia: A Patient s Perspective Patrick A Hagen, MD, MPH Cardinal Bernardin Cancer Center Loyola University Medical Center Maywood, IL Overview 1. What is AML? 2. Who gets AML? Epidemiology

More information

PRELIMINARY PHYTOCHEMICAL SCREENING AND IN-VITRO FREE RADICAL SCAVENGING ACTIVITY OF MELOCHIA CORCHORIFOLIA PLANT EXTRACTS

PRELIMINARY PHYTOCHEMICAL SCREENING AND IN-VITRO FREE RADICAL SCAVENGING ACTIVITY OF MELOCHIA CORCHORIFOLIA PLANT EXTRACTS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article PRELIMINARY PHYTOCHEMICAL SCREENING AND IN-VITRO FREE RADICAL SCAVENGING ACTIVITY OF MELOCHIA

More information

Chapter 11 Nutrition: Food for Thought

Chapter 11 Nutrition: Food for Thought Chapter 11 Nutrition: Food for Thought Do you think about the food that goes into your body and how it affects you? How can you interpret the various nutrition information found in the press? What are

More information

PURE ASTAXANTHIN. Characteristic. Origin. Concept. Function. Product

PURE ASTAXANTHIN. Characteristic. Origin. Concept. Function. Product ASTAXANTHIN 1 2 3 4 5 Characteristic Origin Concept Function Product Characteristic Astaxanthin is a carotenoid. It belongs to a larger class of phytochemicals known as terpenes, which are built from five

More information

A Review of Potential Health Benefits of Flavonoids

A Review of Potential Health Benefits of Flavonoids University of Lethbridge Research Repository OPUS Undergraduate http://opus.uleth.ca Lethbridge Undergraduate Research Journal (LURJ) 2008-06 Patel, Jay M. Lethbridge Undergraduate Research Journal http://hdl.handle.net/10133/1220

More information

This student paper was written as an assignment in the graduate course

This student paper was written as an assignment in the graduate course 77:222 Spring 2005 Free Radicals in Biology and Medicine Page 0 This student paper was written as an assignment in the graduate course Free Radicals in Biology and Medicine (77:222, Spring 2005) offered

More information

Chapter 18. Diet and Health

Chapter 18. Diet and Health Chapter 18 Diet and Health Risk Factors and Chronic Diseases Interrelationships among Chronic Diseases Chronic Disease Heart Disease and Stroke Hypertension Cancer Diabetes The Formation of Plaques in

More information

~PENTOSE PHOSPHATE PATHWAY~ DR. A. TARAB DEPT. OF BIOCHEMISTRY HKMU

~PENTOSE PHOSPHATE PATHWAY~ DR. A. TARAB DEPT. OF BIOCHEMISTRY HKMU ~PENTOSE PHOSPHATE PATHWAY~ DR. A. TARAB DEPT. OF BIOCHEMISTRY HKMU OVERVIEW The pentose phosphate pathway (also called the hexose monophosphate shunt, or 6- phosphogluconate pathway) occurs in the cytosol

More information

September 20, Submitted electronically to: Cc: To Whom It May Concern:

September 20, Submitted electronically to: Cc: To Whom It May Concern: History Study (NOT-HL-12-147), p. 1 September 20, 2012 Re: Request for Information (RFI): Building a National Resource to Study Myelodysplastic Syndromes (MDS) The MDS Cohort Natural History Study (NOT-HL-12-147).

More information

Investigations on its antioxidative and anti-inflammatory potential

Investigations on its antioxidative and anti-inflammatory potential - 1 - CITROZINE Investigations on its antioxidative and CITROFRESH SUPERCONCENTRATE anti-inflammatory potential Investigator and responsible for the correctness of the test protocol, results, conclusions

More information

BIOASTIN Bioastin is product that contains 4 mg astaxantin and 50 i.e. vitamin E (α-tocopherol) per tabl.. Carotenoids are family of around 700 substa

BIOASTIN Bioastin is product that contains 4 mg astaxantin and 50 i.e. vitamin E (α-tocopherol) per tabl.. Carotenoids are family of around 700 substa INTRODUCTION In 1956 Rebecca Gerchman and Daniel Gilbert detected toxic effect of superoxid on aerobs. Till today there are identificated many free radicals. Their toxic effect is registrated in more than

More information

Hematopoietic Stem Cells, Stem Cell Processing, and Transplantation

Hematopoietic Stem Cells, Stem Cell Processing, and Transplantation Hematopoietic Stem Cells, Stem Cell Processing, and Joseph (Yossi) Schwartz, M irector, Hemotherapy and Stem Cell Processing Facility Bone Marrow Can Cure: Leukemia Lymphoma Multiple Myeloma Genetic iseases:

More information

Theory Photochem. Anna Horszwald (Michalska)

Theory Photochem. Anna Horszwald (Michalska) Theory Photochem Anna Horszwald (Michalska) Free radicals Free radicals inflamation mitochondrial disfuntion Lachance P. A. et al. (2001) Antioxidants an intergarative approach, Nutrition, 17,835-838.

More information

Linus Pauling Institute

Linus Pauling Institute The S P R I N G / S U M M E R 2 0 0 9 Oregon State University Linus Pauling Institute R E S E A R C H N E W S L E T T E R A From the Director Balz Frei, Ph.D. LPI Director and Endowed Chair Professor of

More information

Haematopoietic stem cells

Haematopoietic stem cells Haematopoietic stem cells Neil P. Rodrigues, DPhil NIH Centre for Biomedical Research Excellence in Stem Cell Biology Boston University School of Medicine neil.rodrigues@imm.ox.ac.uk Haematopoiesis: An

More information

The Immune System. A macrophage. ! Functions of the Immune System. ! Types of Immune Responses. ! Organization of the Immune System

The Immune System. A macrophage. ! Functions of the Immune System. ! Types of Immune Responses. ! Organization of the Immune System The Immune System! Functions of the Immune System! Types of Immune Responses! Organization of the Immune System! Innate Defense Mechanisms! Acquired Defense Mechanisms! Applied Immunology A macrophage

More information

New Anticancer Agents Targeting the Tumor-Specific Microenvironment (OTT ID 1277)

New Anticancer Agents Targeting the Tumor-Specific Microenvironment (OTT ID 1277) New Anticancer Agents Targeting the Tumor-Specific Microenvironment (OTT ID 1277) Inventor: Xiaohua Peng, Associate Professor, Department of Chemistry and Biochemistry UW-Milwaukee For further information

More information