Granulation Aggregation
|
|
- Osborn Ryan
- 5 years ago
- Views:
Transcription
1 Granulation Aggregation
2 Wet granulation Solvent granulation (crust granules) Binder granulation (sticked granules) Granulation liquid Water Water + alcohol mixture Macromolecular colloidal solution i.e.: starch, gelatine, polividon, cellulose ethers (MC, HEC, HPMC, etc.)
3 Wet granulation Drug(s) + excipient(s) Grinding Blending Agglomeration Granule/Pellet Aggregation Drying Press through sieves (particle size adjustment) Dispersion
4 Wet granulation
5 Melt granulation
6 Melt granulation
7 Melt granulation
8 Melt granulation Advantages Neither solvent nor water used in this process. Good alternative for water sensitive drugs. Fewer processing steps needed since wetting & drying phases eliminated, thus less time consuming There are no requirements on compressibility of active ingredients, entire procedure simple, continuous and efficient. Uniform dispersion of fine particle occurs. Good stability at varying ph and moisture levels. Safe application in humans due to their non-swellable and water insoluble nature. Clinically advantaged dosage forms, such as drug abuse and dose dumping deterrent technology. Sustained, modified and targeted release capabilities. Better content uniformity was obtained from HME process among granules of different size ranges. Reduced number of unit operations. Production of a wide range of performance dosage forms
9 Melt granulation Disadvantages Thermal process (drug/polymer stability). Requires high energy input. The melt technique is such that the process cannot be applied to heat-sensitive materials owing to the elevated temperatures involved. Lower-melting-point binder risks situations where melting or softening of the binder occurs during handling and storage of the agglomerates Higher-melting-point binders require high melting temperatures and can contribute to instability problems especially for heat-labile materials. Flow properties of the polymer are essential to processing. Limited number of available polymer
10 Melt granulation Hydrophylic binders Binder Typical melting range ( C) Gelucire 50/ Poloxamer PEG PEG PEG PEG PEG PEG
11 Binder Melt granulation Hydrophobic binders Typical melting range ( C) Beeswax Carnauba wax Cetyl palmitate Glycerin monostearate Paraffin wax Stearic acid Glyceryl behenate Glyceryl palmitostearate Glyceryl stearate Hydrogenated castor oil Microcrystalline wax Stearyl alcohol 56-60
12 Melt granulation Plasticizers Type Examples Citrate esters Fatty acid esters Sebacate esters Phatalate esters Glycol derivatives Others Triethyl citrate, tributyl citrate, acetyl triethyl citrate, acetyl tributyl citrate Butyl stearate, glycerol monostearate, stearyl alcohol Dibutyl sebacate Dietyl phtalate, dibutyl phtalate, dioctyl phosphate Polyethylene glycol, propylene glycol Triacetin, mineral oil, castor oil
13 Melt extrusion
14 Dry granulation
15 Dry granulation
16 Tasks & Preparations 1. Granule preparation o Pro-C-epT (high shear granulator) o Z-shaped kneader 2. Moisture content determination (analysis of drying process of granules) 3. Grinding, sieve analysis (ball grinder & vibrating sieve) 4. Mixing (rotating cube mixer)
17 Wet granulation Tasks & Preparations Granulatum piracetami (a., b., c.): Piracetam 42.0 g PVP 3.0 g Microcrystalline cellulose 50.0 g a. Aqua purificata 15.0 g b. Aqua purificata 20.0 g c. Aqua purificata 25.0 g Preparation parameters: Impeller (rpm): 1000 RPM Chopper (rpm): 1100 RPM Liquid addition: 10ml/min Pre-mixing: 3 min Pro-C-epT High shear granulator
18 Wet granulation Tasks & Preparations Pellet preparation (a., b.): Avicel PH g Ethylcellulose 4.00 g Lactose g Preparation parameters: Pre-mixing: 3 min Impeller (rpm): 1000 RPM Chopper (rpm): 1100 RPM Liquid addition: 10ml/min Pro-C-epT High shear granulator Total liquid (Aqua purificata): a. 52 ml b. 70 ml
19 Wet granulation Tasks & Preparations Granule preparation I. Solani amylum g Lactose g II. Aqua purificata Solani amylum g 30.0 g Z-shaped kneader Make a suspension with a cold water from the starch. Heat the liquid with water-bath while the starch becomes gelatinous (10-15 min). Cool down the granulating liquid to 40 C and refill the evaporated water. Homogenise the sieved powders, and knead it with small details of granulating liquid in Z-shaped kneader. Break the wet stuff through the granulating sieve IV (1.2 mm). Use oscillating granulator.
FROM SOLVENT TO AQUEOUS COATINGS. (Out of the Frying Pan...) Ralph E. Pondell. Coating Place, Inc. P.O. Box
84-1 FROM SOLVENT TO AQUEOUS COATINGS (Out of the Frying Pan...) Ralph E. Pondell Coating Place, Inc. P.O. Box 930310 Verona, WI 53593 A number of reasons exist for the current high level of interest in
More informationPh. D Synopsis. Mr. Mehul Pravinchandra Patel Page 1
1. INTRODUCTION 1.1. Sustained Drug delivey: 1-6 It is defined as any drug or dosage form modification that prolongs the therapeutic activity of the drug. The amount of drug in the body decrease slowly
More information(12) Patent Application Publication (10) Pub. No.: US 2003/ A1
US 2003.01.18647A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2003/0118647 A1 Seth (43) Pub. Date: (54) EXTENDED RELEASE TABLET OF Publication Classification METFORMIN (51)
More informationContinuous Granulation Using a Twin-Screw Extruder. Lin Zhu, Ph.D. Manufacture Science and Technology AbbVie June, 2016
Continuous Granulation Using a Twin-Screw Extruder Lin Zhu, Ph.D. Manufacture Science and Technology AbbVie June, 2016 What is a twin screw extruder and how to use it for continuous granulation? Dry feed:
More informationComparison - Aqueous vs. Solvent based Ethylcellulose Films. H.S. Hall, K.D. Lillie & R.E. Pondell
Comparison - Aqueous vs. Solvent based Ethylcellulose Films 80-2 by H.S. Hall, K.D. Lillie & R.E. Pondell Ethylcellulose has a long history of use in the pharmaceutical for coating pharmaceuticals in various
More informationANNEXURE -2. Excipients profiles of Compritol ATO 888, Gelucire 43/01, HPMC and PVP and have been described in the following section.
2. EXCIPIENTS PROFILES ANNEXURE -2 Excipients profiles of Compritol ATO 888, Gelucire 43/01, HPMC and PVP and have been described in the following section. 2.1. COMPRITOL 888 Non proprietary names BP:
More informationEP A1 (19) (11) EP A1 (12) EUROPEAN PATENT APPLICATION. (43) Date of publication: Bulletin 2010/39
(19) (12) EUROPEAN PATENT APPLICATION (11) EP 2 233 131 A1 (43) Date of publication: 29.09. Bulletin /39 (1) Int Cl.: A61K 9/ (06.01) A61K 31/00 (06.01) (21) Application number: 09908.8 (22) Date of filing:
More informationLubriTose Mannitol Michael Crowley, Director of R&D, Excipients
LubriTose Mannitol Michael Crowley, Director of R&D, Excipients Introduction Michael Crowley Director of R&D Excipients 158 St. Highway 320 Norwich, NY 13815 PH 315-802-5970 Michael.Crowley@Kerry.com 2
More informationEP B1 (19) (11) EP B1 (12) EUROPEAN PATENT SPECIFICATION
(19) (11) EP 1 864 677 B1 (12) EUROPEAN PATENT SPECIFICATION (4) Date of publication and mention of the grant of the patent: 02.01.08 Bulletin 08/01 (1) Int Cl.: A61K 38/ (06.01) A61K 9/ (06.01) A61K 31/39
More informationMETOLOSE: CONTENTS PAGE
METOLOSE: CONTENTS PAGE 2 Preface What is Metolose Substitution types Specifications 1) Available grades & viscosity 2) Nomenclature 3) Packaging Characteristics of Metolose Properties of Metolose 1) Powder
More information(51) Int Cl.: A61K 9/20 ( ) A61K 31/41 ( )
(19) TEPZZ 94677_A_T (11) (12) EUROPEAN PATENT APPLICATION (43) Date of publication: 2.11.1 Bulletin 1/48 (1) Int Cl.: A61K 9/ (06.01) A61K 31/41 (06.01) (21) Application number: 116790.3 (22) Date of
More informationSTARCH Application Data
STARCH 1500 Application Data Partially Pregelatinized Maize Starch Starch 1500, Partially Pregelatinized Maize Starch, Used as a Binder Disintegrant in High Shear Wet Granulation Comparison to Povidone
More informationEasy, fast and reliable!
Product Overview Easy, fast and reliable! Special easy-to-use preparations for film coating, sugar-coating, colouring and tabletting. Tailormade formulated. s film coating products are one-step coating
More informationPharma & Food Solutions. POLYOX TM Water Soluble Resins Combining Flexibility with Consistency
Pharma & Food Solutions POLYOX TM Water Soluble Resins Combining Flexibility with Consistency POLYOX 9-13 POLYOX 9-13 POLYOX * are nonionic poly (ethylene oxide) polymers that meet all the specifications
More informationEasy, fast and reliable!
Product Overview Easy, fast and reliable! Special easy-to-use preparations for film coating, sugar-coating, colouring and tabletting. s film coating products are one-step coating systems for pharmaceutical
More informationDr.N.Damodharan Professor and head Department of pharmaceutics SRM college of pharmacy
Dr.N.Damodharan Professor and head Department of pharmaceutics SRM college of pharmacy Suppositories are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve
More informationCoatings and Specialty Applications
Coatings and Specialty Applications INTRODUCTION AdvancedChemicalConcepts,Inc.isthepremiersourcefordistributingCoatingsandSpecialty Chemicals,offeringinsightandacomprehensiverangeofmaterialstomeetyourneeds.We
More informationFunctional Excipients for Suppository Applications
Functional Excipients for Suppository Applications Skin Delivery Platform 2016 1 The Skin Delivery Platform Major areas of activity are in 4 pillars PLATFORM : SKIN DELIVERY Dermal Drug Delivery Mildness
More information(51) Int Cl.: A61K 9/20 ( ) A61K 31/5377 ( ) (56) References cited:
(19) TEPZZ 44 799B_T (11) EP 2 442 799 B1 (12) EUROPEAN PATENT SPECIFICATION (4) Date of publication and mention of the grant of the patent: 07.09.16 Bulletin 16/36 (21) Application number: 72746.1 (22)
More informationEmulsions. Purpose of emulsions and of emulsification:
Pharmacist Ghada Hamid Emulsions Emulsion is a dispersion in which the dispersed phase is composed of small globules of a liquid distributed throughout a vehicle in which it is immiscible. The dispersed
More informationBiopharmaceutics Dosage form factors influencing bioavailability Lec:5
Biopharmaceutics Dosage form factors influencing bioavailability Lec:5 Ali Y Ali BSc Pharmacy MSc Industrial Pharmaceutical Sciences Dept. of Pharmaceutics School of Pharmacy University of Sulaimani 09/01/2019
More informationREVISION OF MONOGRAPH ON TABLETS. Tablets
March 2011 REVISION OF MONOGRAPH ON TABLETS Final text for addition to The International Pharmacopoeia This monograph was adopted by the Forty-fourth WHO Expert Committee on Specifications for Pharmaceutical
More informationDRY SYRUPS SWAPNA.M. Ist semester DEPARTMENT OF PHARMACEUTICS UNIVERSITY COLLEGE OF PHARMACEUTICAL SCIENCES KAKATIYA UNIVERSITY, WARANGAL SEMINAR BY
DRY SYRUPS SEMINAR BY SWAPNA.M M.PHARMACY Ist semester DEPARTMENT OF PHARMACEUTICS UNIVERSITY COLLEGE OF PHARMACEUTICAL SCIENCES KAKATIYA UNIVERSITY, WARANGAL CONTENTS DEFINITION CHARACTERISTICS OF SUSPENSIONS
More informationSUSTAINED RELEASE TABLETS USING A PVA DC FORMULATION RESISTANT TO ALCOHOL INDUCED DOSE DUMPING
SUSTAINED RELEASE TABLETS USING A PVA DC FORMULATION RESISTANT TO ALCOHOL INDUCED DOSE DUMPING Dr. Dieter Lubda MilliporeSigma is a business of Merck KGaA, Darmstadt, Germany Agenda: Sustained release
More informationCHAPTER 5: FORMULATION OF SOLID DOSAGE FORM (TABLET & CAPSULES) INTRODUCTION
CHAPTER 5: FORMULATION OF SOLID DOSAGE FORM (TABLET & CAPSULES) INTRODUCTION LEARNING OBJECTIVES The objectives of this unit are to: Understand the formulation of solid dosage form. Understand the characteristic
More informationSK-influx A skin-identical lipid concentrate for enhanced skin moisturization and protection
SK-influx A skin-identical lipid concentrate for enhanced skin moisturization and protection Restores the protective barrier function of the skin Ideal for ageing skin, dry skin and sensitive skin Enhanced
More information13. SUPPOSITORY Suppository Bases. The active substance is prepared in a suitable bases. An ideal suppository bases should carry:
13. SUPPOSITORY They are solid single-dose preparations whose shapes, volumes and consistencies are suitable for rectal administration. There are also such vaginal preparations in the treatment of local
More informationSENTRY TM POLYOX Water Soluble Resins
SENTRY TM POLYOX Water Soluble Resins Technical Information on Stability Introduction Key Points Antioxidants SENTRY POLYOX WSR resins consist of a family of high molecular weight polyethers with nominal
More informationContent Uniformity of Direct Compression tablets
Content Uniformity of Direct Compression tablets Contents 1 Summary 4 2 Introduction 4 3 The role of drug particle size 4 4 The role of mixing strategy 5 5 The role of excipients 5 6 Laboratory data 6
More informationCAPMUL + CAPTEX + ACCONON = SEDDS
OUR SOLUTIONS PORTFOLIO ABITEC products are specifically designed for meeting the solubility challenges of the pharmaceutical industry. Our products can be used alone or in conjunction with one another
More informationPHARMACEUTICAL AID PREPARED BY B.KIRUTHIGA LECTURER DEPT OF PHARMACEUTICAL CHEMISTRY
PHARMACEUTICAL AID PREPARED BY B.KIRUTHIGA LECTURER DEPT OF PHARMACEUTICAL CHEMISTRY Excipients are inactive ingredients used as carriers for the active ingredients in a pharmaceutical product. These may
More informationAAPS Annual Meeting, San Diego, CA November 12, 2017 Short Course. Pharmaceutical Excipients: Biopharmaceutical, QC and Regulatory Considerations
AAPS Annual Meeting, San Diego, CA November 12, 2017 Short Course Pharmaceutical Excipients: Biopharmaceutical, QC and Regulatory Considerations Updating USP-NF Excipient Monographs: Challenges and Opportunities
More informationA Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac
Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*
More informationEmulsions. BY Dr. Jarupa Viyoch. Dept. of Pharmaceutical Technology (2106)
Emulsions BY Dr. Jarupa Viyoch Dept. of Pharmaceutical Technology (2106) Definition Composition Type of emulsions Determination Test Scope Selection of ingredients Emulsion consistency Emulsion theory
More informationFeed ingredients
www.mosselman.eu Feed ingredients Trading & Production of Oleochemicals and related products Tradition in customer relation. Innovation in chemistry and customer service. An extra touch with the use of
More informationTEGO Carbomer 341 ER Emulsion stabilizer, viscosity enhancer for aqueous solutions with high electrolyte tolerance
Emulsion stabilizer, viscosity enhancer for aqueous solutions with high electrolyte tolerance Thickener for mild (low active) personal cleansing formulations Stabilizer for cosmetic emulsions and gels
More informationTABLET DESIGN AND FORMULATION
TABLET DESIGN AND FORMULATION PART 5 Industrial pharmacy 5th class 1st semester TABLET DESIGN AND FORMULATION Conventional oral tablets for ingestion usually contain the same classes of components in addition
More informationIngredients adapted to a fit for use model. APIs allowed the fit for use strategy to work. There has been a shift to designed for purpose
1 Pharmaceutical industry borrowed ingredients from other industries Food Cosmetic Industrial Ingredients adapted to a fit for use model. APIs allowed the fit for use strategy to work that has all changed
More informationLuwax LG Flakes. Technical Information. Montanic Ester Wax
Technical Information TI/EVD 1128 e November 2005 Page 1 of 8 Supersedes edition dated September 1992 = Registered trademark of BASF Aktiengesellschaft Luwax LG Flakes Montanic Ester Wax Hard montanic
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Review Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com ADVANCED GRANULATION TECHNIQUES FOR PHARMACEUTICAL FORMULATIONS
More informationSuppositories. Suppositories: 08/10/2016
Suppositories Suppositories: Suppositories are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve and exert localized or systemic effects. A suppositories
More informationPharma Ingredients & Services. Ibuprofen. Technical Information. = Registered trademark of BASF group USP, Ph. Eur., JP
Technical Information Ibuprofen April 2010 Supersedes issue dated January 2010 03_030720e-10/Page 1 of 14 = Registered trademark of BASF group USP, Ph. Eur., JP Pharma Ingredients & Services 03_030720e-10
More informationRESEARCH ARTICLE. Khemchand Gupta, S.B. Roy, Indrajeet Singhvi
RESEARCH ARTICLE ISSN: 2348-8948 Vol: 3; Issue: 6 PREFORMULATION STUDY IN THE DEVELOPMENT OF A TABLET FORMULATION FOR THE TREATMENT OF ULCERATIVE COLITIS Khemchand Gupta, S.B. Roy, Indrajeet Singhvi Pacific
More informationTEGOSOFT APM Very high polar cosmetic oil with excellent thickening properties for surfactant formulas
TEGOSOFT APM Very high polar cosmetic oil with excellent thickening properties for surfactant formulas Emollient ether with low pour point Effective solubilizer Excellent thickening properties in shampoos
More informationEtat des travaux du GDP
Etat des travaux du GDP (Avril 2018) Item General methods relevant to Q6A Dissolution (rev. 3) 4 Disintegration (rev. 1) 4 Uniformity of content/mass (rev. 2, corr. 1) 4 Tests for specified microorganisms
More informationThe Function of Emollients in Skin Care
The Function of Emollients in Skin Care Benjamin Schwartz Ontario SCC Education Day September 18, 2018 Lipid knowledge for the personal care industry Emollient - definition Wikipedia: complex mixtures
More informationKolliwax HCO. Technical Information. Hydrogenated castor oil powder for pharmaceutical use. = Registered trademark in many countries.
Technical Information Kolliwax HCO September 2015 03_150617e_00/Page 1 of 8 WF-No. 129938 = Registered trademark in many countries Hydrogenated castor oil powder for pharmaceutical use 03_150617e_00 September
More informationBaerlocher Additives for PVC. Lubricants
Baerlocher Additives for PVC Lubricants we add character to plastics The Baerlocher Group of Companies is one of the world s leading suppliers of additives for the plastics industry with a strong focus
More informationEdible Films, Coatings & Processing Aids
Edible Films, Coatings & Processing Aids Mikal E. Saltveit Mann Laboratory, Department of Plant Sciences, University of California, Davis, CA 95616-8631 Use of Edible Films and Coatings Reduce water loss
More informationExcipient Quality & Trouble Shooting. By Seema Trivedi GM, Technical
Excipient Quality & Trouble Shooting By Seema Trivedi GM, Technical Back Ground The Society for Pharmaceutical Dissolution Science (SPDS) had held its 6th Annual International Convention Disso India -
More informationVolker Bühler. Pharmaceutical Technology of BASF Excipients. Pharma Ingredients &Services. Welcome to more opportunities.
Volker Bühler Pharmaceutical Technology of BASF Excipients Pharma Ingredients &Services. Welcome to more opportunities. Volker Bühler Pharmaceutical Technology of BASF Excipients 3 rd revised edition June
More informationLIQUID PREPARATIONS FOR ORAL USE. Final text for addition to The International Pharmacopoeia (November 2007)
November 2007 LIQUID PREPARATIONS FOR ORAL USE Final text for addition to The International Pharmacopoeia (November 2007) This monograph was adopted at the Forty-second WHO Expert Committee on Specifications
More informationThe binding performance of DFE Pharma Starch
The binding performance of DFE Pharma Starch MCC Starch Lactose Inhalation Superdisintegrants We are DFE Pharma We are the global leader in excipient solutions. We develop, produce and market excipients
More informationChallenges and solutions for moisture sensitive API formulation
Challenges and solutions for moisture sensitive API formulation Introduction Today, formulators are looking for alternative processes to reformulate existing products or to formulate New Chemical Entities
More informationBaerlocher Additives for PVC. Lubricants. we add character to plastics
Baerlocher Additives for PVC Lubricants we add character to plastics we add character to plastics The Baerlocher Group of Companies is one of the world s leading suppliers of additives for the plastics
More information02/09/2016. Roles of Excipients in Pharmaceuticals:
Definition: Any substance other than the active drug or prodrug that is included in the manufacturing process or is contained in a finished pharmaceutical dosage form. Excipients are not inactive and have
More informationB. semisolid materials consisting of hydrophilic and hydrophobic portions
CHEM 470 Understanding Emulsions I. Definitions A. Any heterogeneous system which has at least one immiscible or barely miscible liquid dispersed in another liquid in the form of tiny droplets. A. Becher,
More informationTEGOSOFT DEC Emollient for formulations with a light skin feel
TEGOSOFT DEC Emollient for formulations with a light skin feel Low viscosity with a high spreadability Easy to emulsify both in O/W and W/O emulsions Emollient for sprays, foams, creams, and lotions Emollient
More informationEP A1 (19) (11) EP A1 (12) EUROPEAN PATENT APPLICATION. (43) Date of publication: Bulletin 2009/36
(19) (12) EUROPEAN PATENT APPLICATION (11) EP 2 09 81 A1 (43) Date of publication: 02.09.09 Bulletin 09/36 (1) Int Cl.: A61K 9/ (06.01) A61K 31/436 (06.01) (21) Application number: 0838007.3 (22) Date
More informationEmulsion stabilizer, viscosity enhancer for aqueous solutions with high electrolyte tolerance
Technical Information TEGO Carbomer 341 ER Emulsion stabilizer, viscosity enhancer for aqueous solutions with high electrolyte tolerance Intended use Rheological additive Stabilizer Benefits at a glance
More information(51) Int Cl.: A61K 9/20 ( ) A61K 31/4985 ( )
(19) TEPZZ 96 684A_T (11) EP 2 962 684 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: 06.01.16 Bulletin 16/01 (1) Int Cl.: A61K 9/ (06.01) A61K 31/498 (06.01) (21) Application number: 11742.8
More informationAlkyl Benzoate. Applications The multifunctional properties of Finsolv TPP allow it to be used for many applications in personal care areas:
Alkyl Benzoate Finsolv TPP INCI Name: C 12-15 Alkyl Benzoate (and) Dipropylene Glycol Dibenzoate (and) PPG-15 Stearyl Ether Benzoate CAS Nos.: 68477-27-8, 27138-31-4, 108347-90-6 EINECS Nos.: 270-112-4,
More informationPharmaceutics I. Unit 7 EMULSIONS
Pharmaceutics I اينالديصيدلينيات 1 Unit 7 EMULSIONS 1 An emulsion is a dispersion in which the dispersed phase is composed of small globules of a liquid distributed throughout a vehicle in which it is
More informationDevelopment of Up-to-Date Methods for USP/NF Excipient Standards
Development of Up-to-Date Methods for USP/NF Excipient Standards 2018 ExcipientFest Americas San Juan, Puerto Rico 01-May-2018 Hong Wang, Ph.D. Sr. Manager, Science Excipients United States Pharmacopeia
More informationPALMSURF GMS Glyceryl Monostearate: The Versatile Food Emulsifier.
1 P a g e PALMSURF GMS Glyceryl Monostearate: The Versatile Food Emulsifier. PALMSURF Glyceryl Monostearate or GMSs are commercially manufactured via esterification between palm derived palmitic (C 16)/stearic
More informationEXCIPIENTS. EXCELLENCE IN OLEOCHEMICAL EXCIPIENTS AND APIs PHARMA. IOI Oleo GmbH
EXCIPIENTS EXCELLENCE IN OLEOCHEMICAL EXCIPIENTS AND APIs IOI Oleo GmbH PHARMA Contents EXCIPIENTS... 5 Liquid lipids... 6 Solid triglycerides... 8 Partial glycerides... 12 Emulsifiers... 14 Specialties...
More informationPersonal Care. Cremophor A Grades. Technical Information
Technical Information November 2010 Supersedes issue dated March 2008 Cremophor A Grades 04_050402e-03/Page 1 of 8 = Registered trademark of BASF group Nonionic emulsifiers for the manufacture of cosmetic
More informationPHARMACEUTICAL TECHNOLOGY REPORT. Introduction. Experimental Methods
PHARMACEUTICAL TECHNOLOGY REPORT Consumer Specialties ashland.com PTR-8 Page 1 of 6 Are Cellulosic Controlled Release Technologies Vulnerable to Dose Dumping in Ethanolic Dissolution Media? Elanor Pinto,
More informationCONTENTS PAGE. Please note: Preface Matrix system Selection of METOLOSE grades Specifications
Hypromellose CONTENTS PAGE 2 Preface Matrix system Selection of METOLOSE grades Specifications Properties Powder Solution Application Related Patents 3 4-5 6 8 10 13 14 17 Please note: The information
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF MODIFIED REALEASE CAPSULES OF BUDESONIDE 1 K.Veera Kumari*, 2 Dr. Appa Rao, 3 Dr.Shaik.Harun
More informationAttention is drawn to the following places, which may be of interest for search:
A23D EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS (animal feeding-stuffs A23K 10/00-A23K 20/30, A23K 30/00-A23K 50/90; foods or foodstuffs containing edible oils or fats A21D, A23C,
More informationLarge scale production
Large scale production Rotary capsule machine: This machine has two, side-by-side cylinders in each of which half-moulds are cut. These cylinders, like the rollers of a mangle, rotate in contrary direction
More informationABIL Care XL 80 Excellence in Stability, Flexibility and Sensory Properties
ABIL Care XL 80 Excellence in Stability, Flexibility and Sensory Properties Silicone O/W emulsifier providing an outstanding combination of stabilization, flexibility and sensory benefits Formulations
More informationEP A1 (19) (11) EP A1 (12) EUROPEAN PATENT APPLICATION. (43) Date of publication: Bulletin 2009/42
(19) (12) EUROPEAN PATENT APPLICATION (11) EP 2 8 36 A1 (43) Date of publication: 14..09 Bulletin 09/42 (21) Application number: 084239.1 (1) Int Cl.: A61K 9/16 (06.01) A61K 9/ (06.01) A61K 31/4178 (06.01)
More informationRe-compaction properties of lactose and microcrystalline cellulose
Re-compaction properties of lactose and microcrystalline cellulose Individual excipients MCC Starch Lactose Inhalation Superdisintegrants SuperTab 21AN (anhydrous lactose) is the preferred form of lactose
More informationDESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN
Int. J. Chem. Sci.: 10(4), 2012, 2199-2208 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN K. V. R. N. S. RAMESH *, B. HEMA KIRNAMAYI
More informationFormulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch
Abstract K.P.R. Chowdary et al. / International Journal of Pharma Sciences and Research (IJPSR) Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch K.P.R. Chowdary*,
More informationAugust 1, 2008 Supplemental Edition
August 1, 2008 Supplemental Edition Editor s note: In its quest to provide the most up to date information on new silicone technology, the Silicone Spectator endeavours to provide the latest information
More informationPurposes of suppositories
Suppositories Definition Are conical or ovoid, solid prep. For insertion into the body cavity where they melt,dissolve or disperse and exert a local or a systemic effect. Their basis is fat,a wax or glycerol-gelatin
More informationSTABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS
Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN
More informationFolic Acid in Human Nutrition
Folic Acid in Human Nutrition Folic acid is a water soluble B vitamin widely distributed in foods. Deficiencies lead to impaired cell division and altered protein synthesis. Newborn children of women receiving
More informationKolliphor P Grades. Technical Information. Poloxamers for Pharmaceutical Use. = Registered trademark of BASF Poloxamers Ph. Eur.
Technical Information Kolliphor P Grades June 2013 Supersedes issue dated February 2013 03_111136e-03/Page 1 of 8 WF-No. 122937 = Registered trademark of BASF Poloxamers Ph. Eur., Poloxamer USP/NF Poloxamers
More informationPharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs
Mansoura University Faculty of Pharmacy Department of Pharmaceutics Pharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs Thesis presented by Ali Saeed
More informationSTARCH Proven and Trusted Excipient for Performance and Versatility EXCIPIENTS. Effective and economical disintegrant
EXCIPIENTS STARCH 1500 Proven and Trusted Excipient for Performance and Versatility Effective and economical disintegrant Excellent stability for moisture sensitive drugs Manufactured exclusively for the
More informationTEPZZ _5 7B_T EP B1 (19) (11) EP B1 (12) EUROPEAN PATENT SPECIFICATION
(19) TEPZZ _ 7B_T (11) EP 2 2 237 B1 (12) EUROPEAN PATENT SPECIFICATION (4) Date of publication and mention of the grant of the patent:.12. Bulletin /3 (21) Application number: 078632.9 (22) Date of filing:
More information(12) Patent Application Publication (10) Pub. No.: US 2008/ A1
(19) United States US 20080 107731A1 (12) Patent Application Publication (10) Pub. No.: US 2008/0107731 A1 Kohlrausch et al. (43) Pub. Date: (54) DPP IV INHIBITOR FORMULATIONS (30) Foreign Application
More informationDissolution control of direct compression tablets in different test media using novel pregelatinized starch, Swelstar TM MX-1
Dissolution control of direct compression tablets in different test media using novel pregelatinized starch, Swelstar TM MX-1 ASAHI KASEI CHEMICALS CORPORATION CEOLUS R&D DEPARTMENT 1 CONTENTS General
More informationA Legacy of Integrity and Service. Product Portfolio. Acme-Hardesty Sentry Parkway, Blue Bell, PA (800)
Product Portfolio Who We Are A t, our word is our bond. We prioritize sustainability in the bio-based chemical sourcing industry and provide renewable, sustainable alternatives for manufacturers. With
More informationABIL Care 85 Emulsifier for O/W emulsions with a velvety-silky skin feel
ABIL Care 85 Emulsifier for O/W emulsions with a velvety-silky skin feel For sprayable emulsions, creams and lotions Cold processable emulsions are possible Long-lasting skin smoothing perception Low usage
More informationApplication of Starches, Modified Starches and Starch Derivatives in Pharmaceutical Products
57. Starch Convention, Detmold, April 26-28, 2006 K.-J. Steffens Application of Starches, Modified Starches and Starch Derivatives in Pharmaceutical Products Starches, Pharmaceutical Applications _ Starches
More information(51) Int Cl.: A61K 9/00 ( ) A61K 9/20 ( ) A61K 31/00 ( )
(19) TEPZZ _ 7 6A_T (11) EP 3 127 36 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: 08.02.17 Bulletin 17/06 (21) Application number: 1618280.8 (1) Int Cl.: A61K 9/00 (06.01) A61K 9/ (06.01)
More informationFORMULATION CHOICE. How and why they are chosen. Dr Andy Fowles On behalf of ECPA Specification Expert Group
FORMULATION CHOICE How and why they are chosen Dr Andy Fowles On behalf of ECPA Specification Expert Group Topics Why formulate? How to identify formulation options Drivers Principle formulation type overview
More informationFORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS
International Journal of PharmTech Research CODEN( USA): IJPRIF ISSN : 0974-4304 Vol.1, No.3, pp 634-638, July-Sept 2009 FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS K. Reeta Vijaya
More informationOffice europeen des brevets. Publication number: Applicant: Chugai Seiyaku Kabushiki Kaisha 5-1, 5-chome, Ukima Kita-ku Tokyo(JP)
J Europaisches Patentamt European Patent Office Publication number: 0 2 932 Office europeen des brevets A2 EUROPEAN PATENT APPLICATION Application number: 87100549.2 Date of filing: 16.01.87 int. Ci.
More informationZHONGBAO CHEMICALS CO.,LTD
ZHONGBAO CHEMICALS CO.,LTD HANGZHOU ZHONGBAO IMP & EXP CORP.,LTD SINCE 1963 An ISO9001:2000 company Zhongbao Chemicals Co.,LTD is one of the world s specialty chemical companies-including manufacturing
More informationMechanical Processing of Feeds. Anuraga Jayanegara
Mechanical Processing of Feeds Anuraga Jayanegara 1. Chopping (pencacahan) - Forage is chopped/cut mechanically into a smaller length (not less than 5 cm) - Compared to unchopped forage: (1) easier to
More information(12) Patent Application Publication (10) Pub. No.: US 2007/ A1
US 20070202 187A1 (19) United States (12) Patent Application Publication (10) Pub. o.: US 2007/0202 187 A1 Chang et al. (43) Pub. Date: (54) DSAGE FRS (22) Filed: Feb. 20, 2007 (75) Inventors: Chin-ing
More informationTEPZZ Z697_5A_T EP A1 (19) (11) EP A1 (12) EUROPEAN PATENT APPLICATION. (51) Int Cl.: A61K 9/20 ( ) A61K 31/135 (2006.
(19) TEPZZ Z697_A_T (11) EP 3 069 7 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: 21.09.16 Bulletin 16/38 (1) Int Cl.: A61K 9/ (06.01) A61K 31/13 (06.01) (21) Application number: 160172.1
More informationENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.
More informationLAB.2. Tablet Production Methods
LAB.2 Tablet Production Methods Dry methods Direct compression Dry granulation Wet methods Wet granulation Regardless whether tablets are made by direct compression or granulation, the first step, milling
More information