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1 A A rezavafa@iums.ac.ir A IU A)

2 A E ROS ROS DNA TNFTNF- ROS E A A TNF Reacive roein Eryhrocye Sedimenaion Rae Rheumaoid Arhriis () Reacive Oxygen Species (ROS) Malondialdehyde () Tumor Necroizing Facor

3 DAI DAI AR BMI Kg/ m2 mm/ h ENISON c IU A n F H TTZ III SSS Rheumaoid Arhriis Disease Aciviy Index Toal Anioxidaion apaciy Ferric Reducing Abiliy of lasma II Food rocessor II(F) The American Rheumaism Associaion

4 A Kg 2 Kg/m BMI SD E,

5 A m Kcal/d E value value** DAI value* value* a nmol/ ml a µml/ L b b c DAI c d mm/ h d - mg/ L NS NS NS Suden's aired p< a) b)= c) = d)= Jaswal

6 A A BMI Uprichard E A mg/ L E

7 mg/ L Gladys A Uprichard Gladys 1- KamanliA, NazirogluM, AydilekN, e al. lasma lipid peroxidaion and anioxidan levels in paiens wih rheumaoid arhriis. ell Biochem Func 2004; 22: Harris.ED. Eiology and pahogenesis of rheumaoid arhriis. In: Kelly WN, Harris ED, Ruddy S, ediors. Texbook of rheumaology.philadelphia: saunders; KraneSM, SimonL. Rheumaoid arhriis: clinical feaures and pahogenic mechanism. Med li N Am 1986;30: Bauerova.K, Bezek.A. Role of reacive oxygen and nirogen species in eiopahogenesis of rheumaoid arhriis. Gen hysiol Biophy 1999; 18: Biemond, SwaakAJ, KoserJF. roecve facors agains oxygen free radicals and hydrogen peroxide in rheumaoid arhriis synovial fluid. Arhriis Rheum 1984;27: imenmyb, imenob, KacmazB, e al. Oxidan/anioxidan saus of he eryhrocyes from paiens wih rheumaoid arhriis. lin Rheumaol 2000;19: GambhirJK, Lali, JainAK. orrelaion beween blood anioxidan levels and lipid peroxidaion in rheumaoid arhriis. lin Biochem 1997;30: OzurkHS, imenmy, imenob,e al. Oxidan/anioxidan saus of plasma samples from paiens wih rheumaoid arhriis. Rheumaol In 1999;19: Romero FJ, MorellB, Romero MJ, e al. Lipid peroxidaion producs and anioxidans in human disease. Environ Healh erspec 1998;106: KiziluncA, ogalgils, errahoglul. arniine and anioxidans levels in paiens wih rheumaoid arhriis.scand J Rheumaol 1998;27: Taraza, MohoraM, VargoliciB,e al. Imporance of reacive oxygen species in rheumaoid arhriis. Rom J Inern Med 1997;35: SarbanS, KocyigiA, YazarM, EIsikanU. lasma oal anioxidan capaciy, lipid peroxidaion and eryhrocye anioxidan enzyme aciviies in paiens wih rheumaoid arhriis and oseoarhriis. linical Biochemisry 2005;38: SevenA, GuzelS, AslanM, HamuryudanV. Lipid, proein, DNA oxidaion and anioxidan saus in rheumaoid arhriis. linical Biochemisry 2008;41: AkyolO, IsciN, TemelI, OzgocmenS, UZE, MuranM, e al. The relaionship beween plasma and eryhrocye anioxidan enzymes and lipid peroxidaion in paiens wih rheumaoid arhriis. Join bone spine 2001;68: HalliwellB, HoulJR, BlakeDR. Oxidan, inflammaion and aniinflammaory drugs. FASEB J 1998;2: SaoM, MiyazakiT, NagayaT, e al. Anioxidans inhibi umor necrosis facor-alpha mediae simulaion of inerleukin-8,

8 A monocye chemoaracan proein-1 and collogenase expression in culured human synovial cells. J Rheumaol 1996;23: BaeS, KimS, SungM. Inadequae anioxidan nurien inake and alered plasma anioxidan saus of rheumaoid arhriis paiens. Journal of he American college of Nuriion 2003;22: AdamO, Beringer, KlessT,e al. Ani-inflammaory effecs of a low arachidonic acid die and fish oil in paiens wih rheumaoid arhriis.rheumaol In 2003; 23: MyllykangasR, VososujarviR, AhoK,e al. ardiovascular moraliy in women wih rheumaoid arhriis. J Rheumaol 1995; 22: LibbyO. Inflammaion in aherosclerosis. Naure 2002; 420: YildirimK, KarayS, MelikogluMA, e al. Associaion beween acue phase reacan levels and disease aciviy score(das28) in paiens wih rheumaoid arhriis. Ann lin Labsci 2004; 34: ArneF. The American Rheumaism Associaion 1987 revised rieria for he classificaion of rheumaoid arhriis. Arhriis Rheum 1988;31:315. Ghafarpour M, Houshyarrad A, Kianfar H. The manual for household measures, cooking yield facors and edible porion of foods. Naional Nuriion and Food Technology Insiue ublicaion, Tehran, Fransen J, Langenegger T, Michel BA, e al. Feasibiliy and validiy of he DAI, a self-adminisered rheumaoid arhriis aciviy index. Rheumaology 2000;39: SaohK. Serum lipid peroxide in cerebrovascular disorders deermined by a new colorimeric mehod. linical hemical Aca 1978;90: IrisFFB, SrainJJ. The ferric reducing abiliy of plasma (F) as a measure of anioxidan power: he F assay. Analyical Biochemisry 1996; 239: JaswalS, handerh, SoodAK, KaurJ. Anioxidan saus in rheumaoid arhriis and role of anioxidan heraphy. linica Aca 2003; 338: BaskolG, DemirH, BaskolM, KilicE, AesF, KocerD, e al. Assessmen of paraoxonase1 aciviy and malondialdehyde levels in paiens wih rheumaoid arhriis. linical Biochemisry 2005; 38: OzgunesH, GurerH, TuncerS. orrelaion beween plasma malondialdehyde and ceruloplasmin aciviy values in rheumaoid arhriis. lin Biochem 1995;28: HalliwellB. Free radicals, anioxidans and human disease: curiosiy, cause or consequence. Lance 1994; 344: UprichandJE, SurherlandWH, MannJI. Effec of supplemenaion wih omao juice, viamin E and viamin on LDL oxidaion and producs of inflammaory aciviy in ype 2 diabeed. Diabees are 2000; 23: GladysB, hrisopherj, mariond, e al. lasma -reacive proein concenraions in acive and passive smokers: Influence of anioxidan supplemenaion. Journal of he Americanollege of Nuriion 2004; 23: BrinckerhoffE, RodgerRM. Inhibiion by reinoic acid of collagenase producion in rheumaoid synovial cell. N Engl J Med 1997; 296:

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