Intermediates for the life science industry
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1 Intermediates for the life science industry Chemical intermediates for pharmaceutical industry Achiral building blocks Chiral building blocks Protecting groups Reagents Solvents
2 Achiral building blocks C3 spacers 3-Amino-1-propanol min Dimethylamino-1-propanol min Chloro-3-methoxy-propane* min < Methoxypropylamine min < -70 C2 spacers N-(2-Aminoethyl) ethanolamine (AEEA) min < -18 Diethylethanolamine min < -70 Diisopropylaminoethylamine min Ethylenediamine min N-Ethylethanolamine min N-(2-Hydroxyethyl) morpholine min Methoxyethylamine min < -70 *Developmental product. Production on request. Samples are available. Explanation of symbols M = Mol. Weight [] = boiling point = melting point 2
3 Tetrahydropyran derivatives min Formyltetrahydropyran* min Aminomethyltetrahydropyran* 4-Hydroxymethyltetrahydropyran* min Tetrahydropyran-4-carboxylic acid methyl ester* min Heterocycles 2,5-Dimethoxytetrahydrofuran min Imidazole min Methylimidazole min Methylimidazole min N-Methylpyrrolidine min < -80 Morpholine min Piperazine Chips min
4 Piperidine min Pyrrolidine, pure min < Pyrrolidone min Aromatic and aliphatic amines Aniline min Butylamine min tert.-butylamine min Dicyclohexylamine min Diethylamine min Monomethylamine Phenylethylamine min < -60 2,6-Xylidine min *Developmental product. Production on request. Samples are available. Explanation of symbols M = Mol. Weight [] = boiling point = melting point 4
5 Other building blocks 3-Amino-2,2- dimethylpropanamide ( Cyclopentanone min Diethylketone min Ethylhexanoic acid min n-hexylchloroformate min (9 < -70 Hydroxyacetone min Methoxybenzaldehyde min to -3 2-Methylpentanal min Propargyl alcohol min
6 Chiral building blocks Amines Phenylethylamines (R)-1-Phenylethylamine min (S)-1-Phenylethylamine min (R)-1-(4-Methylphenyl)ethylamine* min (15 (S)-1-(4-Methylphenyl)ethylamine* min (15 (R)-1-(2-Methoxyphenyl)ethylamine* min (23 (S)-1-(3-Methoxyphenyl)ethylamine* min (0.5 (R)-1-(4-Methoxyphenyl)ethylamine* min (0.5 (S)-1-(4-Methoxyphenyl)ethylamine min (0.5 (R)-1-(4-Chlorphenyl)ethylamine* min *Developmental product. Production on request. Samples are available. Explanation of symbols M = Mol. Weight [] = boiling point = melting point 6
7 (S)-1-(4-Chlorphenyl)ethylamine* min (R)-1-(4-Fluorphenyl)ethylamine* min (29-30 (S)-1-(4-Fluorphenyl)ethylamine* min (29-30 Bicyclinc amines (R)-1-(1-Naphthyl)ethylamine* min (0.4 (S)-1-(1-Naphthyl)ethylamine* min (0.4 (R)-1-Aminotetraline* min (714 (S)-1-Aminotetraline* min (714 (R)-1-Aminoindane* min (11 1 (S)-1-Aminoindane* min (11 1 (R)-1-(2-Naphthyl)ethylamine* min ( (S)-1-(2-Naphthyl)ethylamine* min (
8 Aliphatic amines (R)-3-Methyl-2-butylamine* min (S)-3-Methyl-2-butylamine* min (R)-2-Hexylamine* min < -20 (S)-2-Hexylamine* min <-20 (S)-3,3-Dimethyl-2- aminobutane* min Cycloaliphatic amines (R)-1-Cyclopropylethylamine* min (S)-1-Cyclopropylethylamine* min (R)-1-Cyclohexylethylamine min (16 (S)-1-Cyclohexylethylamine* min (16 Aryl alkyl amines (R)-1-Phenylpropylamine* min *Developmental product. Production on request. Samples are available. Explanation of symbols M = Mol. Weight [] = boiling point = melting point 8
9 (S)-1-Phenylpropylamine* min Others (S)-1-Methoxy-2- aminopropane* min ( (1R, 2R)-trans-2-Benzyloxycyclohexylamine* min (10 (1S, 2S)-trans-2-Benzyloxycyclohexylamine* min (10 (R)-N-Benzyl-1- phenylethylamine* min (75 (S)-N-Benzyl-1- phenylethylamine* min (75 Alcohols (R)-1-(3,5-Bis-trifluoromethylphenyl)ethanol* min (S)-1-(3,5-Bis-trifluoromethylphenyl)ethanol* (S)-2-Butanol*
10 (S)-2-Pentanol* Acids (R)-Mandelic acid min (R)-ortho-Chloromandelic acid min Protecting groups Benzophenone imine min ( Benzylamine min Benzylchloroformate min. 97 < -18 Butane-2,3-diole min Dihydropyran min Ethylchloroformate min iso-butylvinylether min *Developmental product. Production on request. Samples are available. Explanation of symbols M = Mol. Weight [] = boiling point = melting point 10
11 Ethylvinylether min Methylchloroformate min Pivaloyl chloride min Reagents tert.-amyl alcohol min Diazabicycloundecene P (DBU) min DMF-DMA min Ethyldiisopropylamine (Hünig Base) min Formic acid 99 Formic acid 94 Formic acid Methane sulfonic acid (10 20 N-Methylmorpholine min Propionic acid min
12 Tributylamine plus min < -70 Triethylamine min Tripropylamine min Triphenylphosphine (TPP) min ( Solvents N,N-Dimethylacetamide (DMAC) min Dimethylformamide (DMF) N,N -Dimethylpropylene urea (DMPU) ,4-Dioxane Formamide min N-Methylpyrrolidone (NMP) min *Developmental product. Production on request. Samples are available. Explanation of symbols M = Mol. Weight [] = boiling point = melting point 12
13 2-Methyl-tetrahydrofuran (stabilized) Tetrahydrofuran pharma stab. (THF stabilized) min Tetrahydrofuran pharma unstab. (THF non-stabilized) min Contact us Europe, NAFTA, Asia The data contained in this publication is based on our current knowledge and experience. In view of the many factors that may affect processing and application of our product, the data does not relieve processors from carrying out their own investigations and tests; neither does the data imply any guarantee of certain properties, nor the suitability of the product for a specific purpose. Any descriptions, drawings, photographs, data, proportions, weights etc. given herein may change without prior information and do not constitute the agreed contractual quality of the product. It is the responsibility of the recipient of our products to ensure that any proprietary rights and existing laws and legislation are observed. The safety data given in this publication is for information purposes only and does not constitute a legally binding Material Safety Data Sheet (MSDS). The relevant MSDS can be obtained upon request from your supplier or you may contact BASF directly at info.intermediates@basf.com edition
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