DAILY CARE FOR DRY, IRRITATED AND REACTIVE SKIN. Physiogel A.I. Help your patients restore skin balance and well-being

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1 DAILY CARE FOR DRY, IRRITATED AND REACTIVE SKIN Help your patients restore skin balance and well-being

2 Dry, irritated and reactive skin a question of balance Changes in the lipid barrier (1) Neurological origin (1) Immunological origin (1) Changes in the effectiveness of the cutaneous lipid barrier Increased permeability of the stratum corneum Moisture loss 1 Abnormal penetration of potentially irritating substances 2 Central nervous system dysfunction Release of neurotransmitters and inflammatory cytokines Accentuated nervous response Suggested link between atopy and sensitive skin (1) Atopy higher in subjects with sensitive skin (1) Contact allergy and skin sensitivity share similar cytokine inductions (1) Intact Lipid Barrier versus Disrupted Lipid Barrier (2) 2 1 Dry and sensitive skin Cutaneous tolerance threshold decreased (1,2) Dry, irritated and reactive skin Abnormalities or disruptions in the lipid barrier can lead to greater transepidermal water loss (3). How to restore skin balance and well-being? (1) Farage MA & Maibach HI. Contact Dermatitis. Sensitive skin: closing in on a physiological cause. 2010;62(3): (2) Estrade MN (2006). Conseils en cosmétologie [Cosmetology recommendations], 2 nd Ed. Rueil-Malmaison: Groupe Liaisons SA, 341 pp. (3) Baumann L. Cosmetics and Skin Care in Dermatology. In: Wolff K, Goldsmith LA, Katz SI, et al, eds. Fitzpatrick's Dermatology in General Medicine. 7 th Ed. New York, NY: The McGraw-Hill Companies, Inc; 2008:1-19.

3 Helping restore skin balance and well-being Unique combination of ingredients (1,2)... to protect and soothe dry, irritated and reactive skin (1,2) DMS * Innovative moisturizing base Renews the skin s layered structure Restores the protective function of the cutaneous barrier Reduced cutaneous reactivity Optimizes hydration PEA ** A naturally occuring molecule with anti-inflammatory properties Reduces itch, tightness and prickling sensations Soothing and comfortable sensation * DMS: Derma Membrane Structure ** PEA: Palmitoyl Ethanol Amide (1) Patravale VB, Mandawgade SD. Novel cosmetic delivery systems: an application update. Int J Cosmet Sci. 2008;30(1): (2) Lambert DM, et al. The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr Med Chem Mar;9(6):

4 Physiogel DMS * innovative technology suitable for sensitive skin Unique formulation Clinically tested Lipid film** Structured in layers QNo penetration into deeper skin layers (2) Mimic the stratum corneum Physiogel Physiogel + emulsifier Penetration into the stratum corneum only Penetration into the deeper skin layers Microscopy view (1) Gentle on the epidermis Helps repair the lipid barrier Helps maintain hydration of the skin Structure of the stratum corneum of the skin Physiogel Conventional vesicular structure of an emulsifier Hypoallergenic and non-comedogenic * DMS : Derma Membrane Structure ** Vegetable-based lipids: ceramides, hydrogenated lecithin (phospholipid), squalane, triglyceride, sterol Integration and penetration of the cutaneous barrier by Physiogel with and without an emulsifier evaluated by microscopy after a 300 min incubation phase. Human skin samples were used for this study (2). (1) Llorca MA, et al. Evaluation of the activity of a moisturizing and restoring-action preparation, with lamellar structure, as adjuvant in the treatment of atopic dermatitis and xerotic skin. Rev Intern Dermatol Dermocosm. 2003;6: (2) Wohlrab J, et al. Influence of Hydrogenated Phpspahtidylecholine (HPC)-Cream vs. Emulsifier-Cream on the structure of the lipid Skin-Lipid Barrier. Abstract.

5 PEA*, natural skin molecule with anti-inflammatory properties Naturally occurring agent in cutaneous cells with anti-inflammatory properties (1) Significant improvements in quality of life** (2) QProperties (1) : Anti-inflammatory Soothing In a DMS base QIntensity of pruritus reduced by 60% Result 5 p < vs begining of the study p < vs day ,89 2,66 2 1,97 2,5 2,0 1,5 Clinically tested on irritated and reactive skin **(2) Mean Symptom Scores (Physicians' Assessments)** 1 0 Start After 6 days n = 2126 patients Variation in intensity of pruritus according to a visual analogue scale QLoss of sleep reduced by 60% Result 3 2,58 End p < vs begining of the study p < vs day 6 1,0 0, ,36 1,03 0 Dryness n = 2269 Excoriation n = 2251 Lichenification n = 2241 Evaluation by doctors on 4-point scale where 0 = absence of symptoms and 3 = severe symptoms. p < vs start. Desquamation n = 2261 Erythema n = 2263 Pruritus n = 2265 Start End 0 Start After 6 days End n = 2088 patients Variation in sleeping disorders according to a visual analogue scale * PEA: Palmitoy Ethanol Amide ** Multicenter, observational, non-controlled, prospective cohort study conducted to yield data from physicians and patients with patients 2 to 70 years of age with mild-to-moderate atopic eczema on the efficacy, safety, and acceptance of the study cream (Physiogel AI Cream) under daily life conditions for 4 to 6 weeks of use (3) (1) Lambert DM, et al. The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr Med Chem Mar;9(6): (2) Eberlein B, et al. Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). J Eur Acad Dermatol Venereol. 2008;22(1):73-82.

6 A large range of products for face and body Soothing effects* QSignificant soothing effect of Cream and Body Lotion at 8 hours and at 24 hours in experimentally induced erythema. (1) Cream QContains PEA to protect against irritation, redness and discomfort due to reactive skin (2,3) QReduces itch of dry skin QHypoallergenic, non-comedogenic Lotion QAll the advantages of Cream for the body Balm QA rich and soothing lotion: suitable for very dry skin QSpreads easily on the body: suitable for large areas QContains DMS and PEA: reduces skin itch, irritation and reactivity Latest addition to the range *A single blind, controlled cosmetic study was conducted. The aim of the study was to evaluate, by single application, the activity of 6 topical, cosmetic products on experimentally induced erythema on the backs of 20 healthy volunteers (1) Data on File.Stiefel. Cosmetic Product Dossier. Product Information Pack (PIP). Physiogel AI Lotion (2) Lambert, DM, et al. The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr Med Chem Mar;9(6): (3) Eberlein B, et al. Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). J Eur Acad Dermatol Venereol. 2008;22(1):73-82

7 Redness & Irritation Dry, irritated and reactive skin Cream Very dry, irritated and reactive skin Dry Dry and sensitive skin Physiogel Body Lotion Lotion Balm Latest addition to the range Very dry and sensitive skin Very Dry Physiogel Cream Sensitivity Physiogel Intensive Gentle skin care QHypoallergenic and non-comedogenic No fragrances, preservatives, dyes or potentially irritating agents QMoisturizing base that is skin-compatible Hydrogenated lecithin + DMS Other formulations for daily cleansing care Physiogel Shower-Cream Physiogel Dermo-Cleanser* Physiogel Shampoo-Plus Local contact details * Contains parabens Date of preparation: April 2011 SEU/PSG/0002a/11

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