Memorial and Scientific Program

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2 Memorial and Scientific Program Wednesday, September 13 18:00 Registration & Get together Institute of Pharmaceutical Sciences Humboldtstrasse 46, 8010 Graz Thursday, September 14 9:00 Esterbauer Memorial Session Neven Zarkovic (Zagreb), Valery Bochkov (Graz) Introduction Valery Bochkov (Graz) Welcome Christa Neuper (Rector, University of Graz) Sepp Kohlwein (Graz) Hermann Esterbauer and the University of Graz Giuseppe Poli (Turin) Hermann Esterbauer a pioneer of lipid peroxidation research Neven Zarkovic (Zagreb) The Hermann Esterbauer Life-long Award Koji Uchida (Nagoya) Protein carbonyls as an innate epitope: An insight into the beneficial effects of antioxidants 10:30 Coffee Break 11:00 Session HNE-mediated cell signaling and detoxification of HNE Henry Jay Forman (Los Angeles) HNE-mediated cell signaling Giancarlo Aldini (Milano) Novel molecular approaches for improving enzymatic and nonenzymatic detoxification of 4-hydroxynonenal: toward the discovery of a novel class of bioactive compounds 11:50 Lunch break 13:15 Session

3 HNE and oxidized lipids in atherosclerosis and other age-related diseases (I) Gabriella Marisa Leonarduzzi (Turin) Oxidized lipids in age-related diseases Giovanni E. Mann (London) Enhanced sensitivity to 4-hydroxynonenal induced damage and impaired redox signaling in human endothelium in gestational diabetes Anne Nègre-Salvayre (Toulouse) Pro-atherogenic effects of 4-hydroxynonenal Dennis Petersen (Aurora) Interactions of electrophilic products of lipid peroxidation with hepatic proteins: Targets and consequences 14:55 Coffee Break 15:25 Session HNE and oxidized lipids in atherosclerosis and other age-related diseases (II) Françoise Guéraud (Toulouse) Dietary HNE and other lipid oxidation products in the development of colorectal carcinogenesis Ana Čipak Gašparović (Zagreb) Role of HNE in communication between cancer stem cells and microenvironment Luigi Iuliano (Rome) Translational implications of cholesterol autoxidation 16:40 Coffee Break 17:00 Poster Session 20:00 Conference Dinner Hotel WIESLER Salon Frühling Grieskai 4-8, 8010 Graz Friday, September 15 9:00 Session Analytical strategies to uncover the diversity of lipid peroxidation products and their biological effects Franz Tatzber (Graz)

4 Maria Fedorova (Leipzig) Analytical strategies to uncover the diversity of lipid peroxidation products and their biological effects Corinne Spickett (Birmingham) Chemistry and analysis of prominent lipid oxidation compounds Willibald Wonisch (Graz) High-throughput screening of oxidative stress biomarkers significance, precision and cost-effectiveness 10:15 Coffee Break 10:45 Session Lipid peroxidation and pharmalogical interventions Werner Siems (Bad Harzburg) Lipid peroxidation and pharmaceutical drugs Huveyda Basaga (Istanbul) Cross talk between Bcl-2 and I B kinase (IKK)-mediated apoptosis upon exposure to 4-hydroxynonenal (HNE) Huiyong Yin (Shanghai) The role of lipid peroxidation during the progression of human hepatocellular carcinoma Norbert Leitinger (Charlottesville) Oxidized phospholipids and phenotypic polarization of macrophages 12:25 Lunch Break 14:00 Session Oxidative stress & antioxidants: Distress or eustress? Randy Jirtle (Raleigh), Peter Eckl (Graz) Etsuo Niki (Kyoto) Oxidative stress and antioxidants: Distress or eustress? Randy Jirtle (Raleigh) Radiation-induced oxidative stress alters disease susceptibility by modifying the epigenome

5 Nikolaus Bresgen (Salzburg) Oxidative stress and cell death The role of iron Tilman Grune (Nuthetal) Redox regulation in aging: role of protein aggregates Elżbieta Skrzydlewska (Białystok) Antioxidants and HNE in the regulation of redox homeostasis 16:15 Coffee Break 16:45 Public Panel Discussion The Janus-face of oxidative stress Moderation: Sonja Saurugger (Kleine Zeitung, Graz) Etsuo Niki (Kyoto) What means oxidative stress Randy Jirtle (Raleigh) Irradiation-induced oxidative stress Neven Zarkovic (Zagreb) Pro- and antiproliferative effects of lipid peroxidation products on cancer cells 17:45 Closing remarks Neven Zarkovic Social Programme (optional, booking required) Saturday, September 16 Excursion to the Fortress of Deutschlandsberg and the Western Styrian Wine Road 10:00 Departure from the University Main Building 11:00 Archeological Museum Deuschlandsberg 12:30 Lunch at the Castle Deutschlandsberg 14:30 Ride along the Schilcher Weinstrasse 15:30 Brettljause at Restaurant Jagawirt 19:00 Arrival in Graz Contact and Information University of Graz Institute of Pharmaceutical Sciences Humboldtstrasse 46/III 8010 Graz, Austria +43 (0) 316/