Lipase and Pancreatic Amylase Activities in Tissues and in Patients with Hyperamylasemia

Size: px
Start display at page:

Download "Lipase and Pancreatic Amylase Activities in Tissues and in Patients with Hyperamylasemia"

Transcription

1 CLINICAL CHEMISTRY Originl Article Lipse nd Pncretic Amylse Activities in Tissues nd in Ptients with Hypermylsemi FRED APPLE, PH.D, PETER BENSON, M.D., LYNNE PREESE, MT, M.B.A., STEVEN EASTEP, M.D., LAURA BILODEAU, M.D., AND GREG HEILER, M.D. Lipse, pncretic mylse, nd totl mylse ctivities were mesured in nondisesed nd disesed humn pncretic tissues nd in six different loctions of the humn digestive system. In ddition, it ws determined whether serum lipse nd pncretic mylse tests could replce the totl mylse test to improved dignostic efficiency in the evlution of cute pncretitis in hypermylsemic ptients. Nondisesed pncretic tissue contined 4.5 times more lipse ctivity thn totl mylse ctivity. Disesed pncretic tissue contined less ctivity for both lipse nd totl mylse compred to norml tissue. The totl mylse ctivity of the pncres ws comprised solely of pncretic mylse. Tissue obtined from six different ntomic loctions in the digestive system contined 35 to 45 times less lipse nd totl mylse ctivity compred to the pncres. Totl mylse ctivity of the digestive system tissues were comprised of 25% pncretic nd 75% slivry isomylses. Lipse, pncretic mylse, nd totl mylse levels lso were determined in seril serum smples from 17 consecutive hypermylsemi ptients dmitted with possible cute pncretitis. The serum lipse level remined higher thn norml longer thn either the totl mylse nd pncretic mylse levels. In ptients with hypermylsemi of pncretic origin, poor correltion ws observed t dmission between serum pncretic mylse nd serum lipse. Not ll ptients with elevted lipse hd n elevted pncretic mylse level nd vice vers. However, in every ptient pncretic disese would hve been detected by the elevtion of either lipse or pncretic mylse levels. Dignostic efficiency for pncretic disese using serum pncretic mylse, lipse, nd totl mylse tests ws 94.1%, 76.5%, nd 64.7%, respectively. These dt suggest tht lipse nd pncretic mylse tests re specific for the pncres nd might be considered replcements for totl mylse s the stt or routine lbortory test for the dignosis of pncretic tissue injury. (Key words: Pncretic injury; Lipse; Pncretic mylse; Serum enzyme ssys) Am J Clin Pthol 1991; 96: Severl orgns contribute to mylse ctivities in serum, nd vriety of extrpncretic disorders contribute to n increse in totl serum mylse ctivity. 3 In norml individuls, totl serum mylse ctivity results from mixture of pncretic isomylse (found lmost exclusively in the pncres) nd slivry isomylse (found in vrious orgns). Overll pncretic isomylse constitutes bout 40% of the totl mylse ctivity. 4 The cinr cells of the pncres lso re the primry source of serum lipse. Thus, serum lipse ctivity should increse the specificity for the dignosis of cute pncretitis. The dignosis of cute pncretitis is not uncommonly From the Deprtment of Lbortory Medicine nd Pthology, mde Hennepin County Medicl Center, Minnepolis, in the presence of normomylsemi. In recent Minnesot. The dignosis of cute pncretitis hs lwys been chllenge to clinicins. During the pst 10 yers, techniques such s ultrsonogrphy, lprotomy, endoscopic retrogrde cholngiopncretogrphy, nd computed xil tomogrphy, s well s clinicl findings hve ided in the evlution of pncretitis.' However, the dignosis often hs relied on lbortory mesurement of serum totl mylse ctivity. 2 With the incresing incidence of pncretitis during the pst severl yers, efforts hve been concentrted on improving the specificity nd simplicity of enzyme ssys for the dignosis of cute pncretitis. Received November 5, 1990; received revised mnuscript nd ccepted for publiction My 17, Supported in prt by Boehringer Mnnheim Dignostics nd Robert Gnz, M.D., for the collection of tissue specimens. Address reprint requests to Dr. Apple: Clinicl Lbortories #812, Hennepin County Medicl Center, 701 Prk Avenue South, Minnepolis, Minnesot study by Clvien nd ssocites, 5 68% of 65 normomylsemic ptients with cute pncretitis were found to hve elevted lipse levels. Until recently, the clinicl efficcy of pncretic mylse nd lipse ssys hve been limited by the lck of specific nd sensitive utomted ssys. 2,6 Improvements in technology for both the lipse nd pncretic isomylse ssys now fford lbortory workers 610

2 APPLE ET AL. 611 Lipse nd Pncretic Amylse Activity in Hypermylsemi the bility to provide clinicins with improved dignostic enzymology testing for the evlution of ptients with cute or chronic bdominl distress with possible pncretitis, replcing the nonspecific serum totl mylse 7-9 ssy. The present study hd two primry gols. First, we quntitted the ctivity of lipse, pncretic mylse, nd totl mylse in nondisesed nd disesed humn pncreses nd in humn digestive system tissues to determine tissue specificity for ech enzyme. Second, we determined the clinicl dignostic efficiency of pncretic mylse nd lipse ssys in serum from ptients dmitted through the emergency deprtment with the possible dignosis of cute pncretitis. Tissues METHODS Pncreses were hrvested within 9 hours fter deth from two mle subjects (A nd B) who died s result of hed trum in motor vehicle ccidents. Neither hd clinicl or gross indiction of pncretitis. Pncreses lso were hrvested within 7 hours fter deth from femle subject (C) nd mle subject (D) who died s result of trum in motorcycle ccident nd from drug overdose, respectively. Both of the ltter subjects hd known histories of lcoholism nd chronic pncretitis. Ech of the ltter intct pncreses t hrvest hd gross indictions of ptchy ft necrosis nd hemorrhge. Pncres frgments ( mg) were obtined from six ntomic loctions from the hed (loction 6) to til (loction 1) of the pncres (Tble 1). Visible res of necrosis were voided during tissue smpling. In ddition, tissue specimens (5 mg) lso were obtined t biopsy from six different n- Antomic Loction TABLE 1. LIPASE AND AMYLASE ACTIVITIES IN NORMAL AND DISEASED PANCREATIC TISSUE FROM FOUR SUBJECTS Nondisesed Lipse, U/g Disesed A B C D Nondisesed Amylse, U/g Disesed A B C D Men SD Loction I denotes the til nd loction 6 denotes the hed of the pncres; results re expressed s U/g wet weight of tissue; mylse ctivity is 100% pncretic mylse. SD stndrd devition. tomic loctions of the digestive system, s well s from six different pncreses. Tissues were trimmed to remove excess connective tissue nd immeditely frozen t 70 C nd thwed overnight t 4 C before the nlyses. All tissues were homogenized in 1- to 5-mL ice-cold phosphte buffer (0.2 mol/ L potssium phosphte, ph 7.0) nd centrifuged to remove cellulr debris. The superntnts were nlyzed for totl mylse, pncretic mylse, nd lipse ctivities, s described below (in the Ptients section). Results re expressed s U/g wet weight tissue or s U/mg totl protein. Agrose gel electrophoresis ws used to determine qulittively the distribution of tissue isomylses. 10 Ptients Serum ws obtined t dmission s well s pproximtely 12, 24, nd 48 hours fter dmission in 17 consecutive hypermylsemic ptients dmitted through the emergency deprtment with the possible clinicl dignosis of cute pncretitis. Serum ws frozen t - 20 C until time of ssy. For enzyme clernces, men enzyme vlues were clculted t ech time point (Fig. 2). The dignosis of pncretitis nd dmission to the hospitl initilly ws bsed on history of bdominl pin tht ws consistent with cute pncretitis. The enzyme vlues obtined in the emergency deprtment were not used to estblish the dignosis but were used for clinicl confidence. The etiology of the pncretitis in most cses (9 of 14) ws lcohol buse. The etiologies of the remining five cses were unknown. The finl dignoses in 35% of cses were confirmed by lprotomy, computed tomogrphy, ultrsonogrphy, or t utopsy. Serum totl mylse nd lipse (with colipse cofctor) ctivity were determined on the utomted Kodk Ektchem 400 nlyzer (Estmn Kodk, Rochester, NY) ccording to the mnufcturer's protocols. Reference rnges were U/L nd U/L, respectively. Pncretic isomylse ws determined on Cobs-Bio (Roche Dignostic Systems, Montclir, NJ) using the Boehringer Mnnheim (Indinpolis, IN) enzymtic colorimetric test, pncretic lph mylse p-nitrophenylmlthoheptoside. 9 In this ssy, the ctivity of humn slivry isomylse is inhibited by monoclonl ntibody tht does not ffect pncretic isomylse. The ctivity of pncretic isomylse is then mesured t 37 C using p-nitrophenyl-d-mltopeptoside substrte. The reference rnge ws U/L. (It should be noted tht under the current ssy conditions, totl mylse nd pncretic mylse levels re mesured by different ssys; therefore, 1 U/L of totl mylse does not equl 1 U/L of pncretic isomylse.) Dignostic efficiency, sensitivity nd predictive vlues of positive test were clculted. Vol. 96 No. 5

3 612 CLINICAL CHEMISTRY Originl Article U/G LIPASE, LU < Q D A, NORMAL 1 i AMYLASE, U/G B, DISEASED D D G i AMYLASE, U/G FIG. 1. Reltionship between mylse nd lipse ctivity (U/g) in tissues obtined from nondisesed (norml) nd disesed pncreses. RESULTS Tble 1 shows the lipse nd mylse ctivities from six distinct ntomic loctions in nondisesed nd disesed pncretic tissue from four subjects. From til to hed in nondisesed tissue (subjects A nd B), lipse ctivity (1819 U/g) ws 4.5 times greter thn mylse ctivity (418 U/g) per grm of wet weight tissue. In tissue obtined from subjects (C nd D) with history of chronic pncretitis, there ws substntilly less ctivity for both lipse (1340 U/g) nd mylse (246 U/g), representing 26% nd 41% depletions. Fourfold differences in mylse nd lipse ctivities existed within ech disesed pncres. Figure 1 shows tht lthough there ws n excellent correltion (r = 0.90) between tissue lipse nd mylse in nondisesed pncreses, there ws very poor correltion (r = 0.17) in enzyme ctivity in the disesed tissue. Tble 2 shows the totl mylse, pncretic mylse, nd lipse ctivities is six different loctions in the digestive system compred to the pncres. The pncres contined 35 to 45 times more ctivity per milligrm of totl protein for totl mylse, lipse, nd pncretic mylse thn ny of the six different digestive system loctions. The totl mylse ctivity of the pncres consisted solely of pncretic mylse, nd the digestive system totl mylse ctivity ws comprised of less thn 50% pncretic mylse t ll six sites. The serum enzyme clernce profiles for totl mylse, pncretic isomylse, nd lipse from the 17 consecutive emergency deprtment dmissions with possible dignosis of cute pncretitis re shown in Figure 2. Although there ws good correltion of totl mylse with pncretic isomylse for ll smples (r = 0.81), the correltion improved (r = 0.95) when smples with norml lipse were excluded. A poor correltion existed in dmission specimens between serum pncretic isomylse nd lipse ctivities, s shown in Figure 3. Tble 3 shows the sensitivity, dignostic efficiency, nd predictive vlue of positive test for ll three ssys bsed on the dmission serum specimen. The dignostic sensitivity nd efficiency with this smll group of ptients for cute pncretitis ws best using serum pncretic mylse, followed by lipse nd totl mylse. DISCUSSION The dignosis of pncretitis often is difficult to mke becuse this condition must be differentited from other bdominl disorders with similr clinicl fetures.' Until TABLE 2. TOTAL AMYLASE, PANCREATIC AMYLASE, AND LIPASE ACTrVITY IN THE PANCREAS AND IN SIX DIFFERENT ANATOMIC LOCATIONS OF THE HUMAN DIGESTIVE SYSTEM Loction Totl Amylse Pncretic Amylse Lipse Pncres (n = 6) Duodenl bulb (n = 4) Pyloric ntrum (n = 11) Angulr notch (n = 1) Corpus (n = 15) Gstroesophgel junction (n = 1) Esophgus(n = 3) 100% pncretic 0.60 (0.73) 0.07(0.13) (0.15) 0.94(1.5) 9.0 (7.0) 0.28 (0.45) 0.02 (0.03) 0.01 (0.02) 0.02 (0.3) 7.8 (3.2) 0.13(0.22) 0.03 (0.04) (0.36) 0.01 (0.01) ' Results re expressed s men (stndrd devition) of ctivities, U/mg totl protein. AJ.C.P. November 1991

4 APPLE ET AL. 613 Lipse nd Pncretic Amylse Activity in Hypermylsemi Dy After Admission to Hospitl o o LIPASE U/L FlG. 2. Enzyme clernces fter the onset of bdominl pin in ptients dmitted for pncretitis for serum lipse, pncretic mylse, nd totl mylse ctivities; ULN = upper limit of norml reference rnge. Ech time point represents the men vlue of ech enzyme for ll 17 ptients. FlG. 3. Reltionship between dmission serum pncretic mylse nd lipse ctivities in ll ptients dmitted with possible dignosis of cute pncretitis (r = 0.16). vilble, improved serum lipse ssy (with colipse cofctor) nd pncretic mylse ssy (which uses inhibiting monoclonl ntibodies ginst slivry mylse) hve been shown cliniclly to be interchngeble tests for the dignosis of pncretitis. 5 ' 7 ' Although it is not thoroughly representtive popultion for studying dignostic efficiency, the current study demonstrted tht serum pncretic mylse nd serum lipse were the most cliniclly sensitive nd dignosticlly efficient ssys in ptients treted in the emergency deprtment for possible cute pncretitis. This correlted with severl other lrger popultion studies. Lott nd co-workers 7 showed tht the clinicl sensitivity nd specificity of lipse ssy (100% nd 62%, respectively) ws much better thn totl mylse ssy (96% nd 34%, respectively) in 175 ptients dmitted for cute pncretitis. Clvien nd co-workers 5 showed tht cute pncretitis nd normmylsemi were not n uncommon combintion; however, the serum lipse level ws elevted in 68% of 65 normmylsemic cses. For the emergency dignosis of cute pncretitis in more thn 250 cses of vried clinicl findings, lipse nd pncretic mylse were considerbly more sensitive nd specific, with few to no flse-positive results when compred to totl mylse. 14 Finlly, Vn Lente nd ssocites 15 hve shown tht lipse nd pncretic mylse re interchngeble serum mrkers, with high clinicl sensitivity nd specificity for cute pncretitis. These findings demonstrte tht the mesurement of totl mylse is not sefficient s the new nd improved serum lipse- nd pncretic-specific mylse ssys. Multiple fctors contribute to the bsence of hypermylsemi in the presence of hyperlipsemi. These include n erlier return to norml for serum mylse during hospitliztion (Fig. 2) nd the inbility of disesed pncreses to relese mylse (Tble 1). In the present investigtion, we describe two dditionl mechnisms. First, lipse ctivity ws four times greter thn mylse ctivity in the pncres (Tble 1). Second, pncretic tissue obtined from chronic pncretitis subjects demonstrted substntil decline in both mylse nd lipse ctivity, with mylse ctivity showing greter decrese compred to lipse (41 % versus 26%; Tble 1, Fig. 1). These findings recently, the serum totl mylse test hs been the dignostic lbortory test of choice in this setting. However, severl studies (s well s the tissue nd serum results described in the current study) show tht serum lipse nd serum pncretic (specific) mylse ssys re more sensitive nd specific for the dignosis of pncretic injury 2,4,5,7,11-15 The rpid, simple-to-perform, nd redily TABLE 3. SENSITIVITY, EFFICIENCY, AND PREDICATIVE VALUES OF SERUM PANCREATIC ENZYME ASSAYS Sensitivity (%) Efficiency (%) Positive predictive vlue (%) Totl Amylse Lipse Pncretic Amylse Vol. 96 No. 5

5 614 CLINICAL CHEMISTRY Article would explin why cute pncretitis, normomylsemi, nd hyperiipsemi re not n uncommon finding in clinicl prctice. Regrding the specificity of elevted serum lipse nd pncretic mylse, ourfindingsshowed tht only the pncres contined substntil ctivities of either enzyme when compred to severl other ntomic loctions in the digestive system (Tble 2). To our knowledge, this is the first report to mesure tissue lipse ctivities in the pncres nd digestive system. Our finding of smll quntity nd mixture of pncretic nd slivry isomylses in nonpncretic tissue correlted with the findings of Whitten nd ssocites. 3 From chrt review in the current study, it ppers tht elevtions of either pncretic mylse or lipse represent direct pncretic injury or secondry relese from the pncres due to other pthologic conditions. Combined mesurement of pncretic mylse with lipse or totl mylse with lipse did not increse the sensitivity or dignostic efficiency (89%, 85%, nd 86%, respectively). Specificity clcultions were not performed in the current study becuse of the high prevlence of disese (pncretitis, 14 of 17 ptients) in the smll ptient popultion studied. From ourfindingswe conclude tht (1) lipse nd pncretic mylse levels re specific for the pncres; (2) for the dignosis of cute pncretitis, clinicl sensitivity nd specificity re improved by mesuring lipse nd pncretic mylse levels; nd (3) ourfindings,together with those of others, provide sufficient informtion to consider replcement of the mesurement of totl serum mylse ctivity s n indictor of cute pncretitis. However, the elimintion of the mesurement of serum totl mylse in clinicl lbortories will depend on the generl vilbility of instrumenttion for the mesurement of serum lipse (colipse) nd serum pncretic mylse levels. When serum lipse nd pncretic mylse ctivities re found to be elevted, it should suggest some form of pncretic tissue injury. REFERENCES 1. Mooss AR. Dignostic tests nd procedures in cute pncretitis. N Engl J Med 1984; 311: Kolrs JC, Ellis CJ, Levitt MD. Comprison of serum mylse pncretic isomylse nd lipse in ptients with hypermylsemi. DigDisSci 1984;29: Whitten RO, Chndler WL, Thoms MG, et l. Survey of mylse ctivity nd isomylses in utopsy tissue. Clin Chem 1988; 34: Pnteghini M, Pgni F. Dignostic vlue of mesuring pncretic lipse nd the P 3 isoform of the pncretic mylse isoenzyme in serum of hospitlized hypermylsemic ptients. Clin Chem 1989;35: Clvien PA, Robert J, Meyer P, et l. Acute pncretitis nd normomylsemi. Ann Surg 1989; 210: Koehler DF, Eckfeldt JH, Levitt MD. Dignostic vlue of routine isomylse ssy of hypermylsemic serum. Gstroenterology 1982; 82: Lott JA, Ptel ST, Swhney AK, et l. Assys of serum lipse: Anlyticl nd clinicl considertions. Clin Chem 1986; 32: Rosenblum JL. Direct, rpid ssy of pncretic isomylse ctivity by use of monoclonl ntibodies with low ffinity for mcromylsemic complexes. Clin Chem 1988; 34: Tietz NW, Burling A, Gerhrdt W, et l. Multicenter evlution of specific pncretic isomylse ssy bsed on double monoclonl-ntibody technique. Clin Chem 1988; 34: Gillrd BK. Quntittive gel-electrophoretic determintion of serum mylse isoenzyme distributions. Clin Chem 1979; 25: Werner M, Steinberg WM, Puley C. Strtegic use of individul nd combined enzyme indictors for cute pncretitis nlyzed by receiver-opertor chrcteristics. Clin Chem 1989; 35: Kzmierczk SC, VnLente F. Incidence nd source of hypermylsemi fter crdic surgery. Clin Chem 1988; 34: Hfkenscheid JC, Hessels M, Wetzels JF. Clernce of pncretic nd slivry mylse in norml subjects. Clin Chem 1985; 31: d'eril GM, Bosoni T, Lesi C. Pncretic mylse in serum for differentil dignosis of cute pncretitis nd cute bdominl diseses. Clin Chem 1989; 35: VnLente F, Kzmierczk SC. Immunologiclly-derived pncretic mylse, pncretic lipse, nd totl mylse compred s predictors of pncretic inflmmtion. Clin Chem 1989; 35:1542.

Diabetes mellitus secondary to pancreatic diseases (type 3c): The effect of smoking on the exocrine endocrine interactions of the pancreas

Diabetes mellitus secondary to pancreatic diseases (type 3c): The effect of smoking on the exocrine endocrine interactions of the pancreas 764062DVR0010.1177/1479164118764062Dibetes & Vsculr Disese ReserchŚliwińsk-Mossoń et l. reserch-rticle2018 Originl Article Dibetes mellitus secondry to pncretic diseses (type 3c): The effect of smoking

More information

C reactive protein: an aid to assessment and

C reactive protein: an aid to assessment and C rective protein: n id to ssessment nd monitoring of cute pncretitis J Clin Pthol 1984;37:27-211 AD MAYR,* MJ McMAHON,* MARGART BOWN,t H COOPRt From the *University Deprtment ofsurgery, Generl Infrmry,

More information

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number

Clinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess

More information

phosphatase isoenzyme activity: estimation of

phosphatase isoenzyme activity: estimation of J Clin Pthol 1988;41:202-206 Quntittive method for determining serum lkline phosphtse isoenzyme ctivity: estimtion of intestinl component M J PEAKE, M PEJAKOVIC, G H WHITE From the Deprtment ofbiochemistry

More information

Hepatitis A virus (HAV) infection contributes approximately

Hepatitis A virus (HAV) infection contributes approximately Multiple Fctors Contribute to Positive Results for Heptitis A Virus Immunoglobulin M Antibody Adnn Altoom, MD, PhD; M. Qsim Ansri, MD; Jennifer Cuthbert, MD Context. In the United Sttes, successful vccintion

More information

BENIGN ulceration along the greater curvature of the pars media of the

BENIGN ulceration along the greater curvature of the pars media of the BENIGN ULCERS OF THE GREATER CURVATURE OF THE STOMACH Report of Two Cses CHARLES H. BROWN, M.D. Deprtment of Gstroenterology nd ANTHONY D. INTRIERE, M.D.* BENIGN ulcertion long the greter curvture of the

More information

Comparison of three simple methods for the

Comparison of three simple methods for the J. clin. Pth. (1967), 2, 5 Comprison of three simple methods for the ssessment of 'free' thyroid hormone T. M. D. GIMLETTE1 From the Rdio-Isotope Lbortory, St. Thoms's Hospitl, London SYNOPSIS A dilysis

More information

Assessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II

Assessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II Assessment of Depression in Multiple Sclerosis Vlidity of Including Somtic Items on the Beck Depression Inventory II Peggy Crwford, PhD; Noh J. Webster, MA Signs nd symptoms of multiple sclerosis (MS)

More information

Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification

Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification Hshimoto et l. BMC Phrmcology nd Toxicology (2017) 18:74 DOI 10.1186/s40360-017-0180-3 RESEARCH ARTICLE Open Access Dose-dependent effect of dptomycin on the rtificil prolongtion of prothrombin time in

More information

METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY

METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY METHOD 4010 SCREENING FOR PENTACHLOROPHENOL BY IMMUNOASSAY 1.0 SCOPE AND APPLICATION 1.1 Method 4010 is procedure for screening solids such s soils, sludges, nd queous medi such s wste wter nd lechtes

More information

Comparative effectiveness of the tumour diagnostics,

Comparative effectiveness of the tumour diagnostics, Gut, 1987, 28, 323-329 Comprtive effectiveness of the tumour dignostics, C 19-9, C 125 nd crcinoembryonic ntigen in ptients with diseses of the digestive system K SKMOTO, Y HG, R YOSHIMR, H GMI, Y YOKOYM,

More information

Community. Profile Big Horn County. Public Health and Safety Division

Community. Profile Big Horn County. Public Health and Safety Division Community Helth Profile 2015 Big Horn County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl

More information

Paper-based skin patch for the diagnostic screening of cystic fibrosis

Paper-based skin patch for the diagnostic screening of cystic fibrosis Electronic Supplementry Mteril (ESI) for ChemComm. This journl is The Royl Society of Chemistry 2015 Supplementry informtion Pper-bsed skin ptch for the dignostic screening of cystic fibrosis Xun Mu,*

More information

ORIGINAL ARTICLE. Diagnostic Signs of Accommodative Insufficiency. PILAR CACHO, OD, ÁNGEL GARCÍA, OD, FRANCISCO LARA, OD, and M A MAR SEGUÍ, OD

ORIGINAL ARTICLE. Diagnostic Signs of Accommodative Insufficiency. PILAR CACHO, OD, ÁNGEL GARCÍA, OD, FRANCISCO LARA, OD, and M A MAR SEGUÍ, OD 1040-5488/02/7909-0614/0 VOL. 79, NO. 9, PP. 614 620 OPTOMETRY AND VISION SCIENCE Copyright 2002 Americn Acdemy of Optometry ORIGINAL ARTICLE Dignostic Signs of Accommodtive Insufficiency PILAR CACHO,

More information

Safety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA

Safety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,

More information

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1

EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 Swine Dy 2001 Contents EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 C. W. Hstd, S. S. Dritz 2, J. L. Nelssen, M. D. Tokch, nd R. D. Goodbnd Summry Two trils were

More information

Community. Profile Powell County. Public Health and Safety Division

Community. Profile Powell County. Public Health and Safety Division Community Helth Profile 2015 Powell County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk

More information

Community. Profile Yellowstone County. Public Health and Safety Division

Community. Profile Yellowstone County. Public Health and Safety Division Community Helth Profile 2015 Yellowstone County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl

More information

Community. Profile Anaconda- Deer Lodge County. Public Health and Safety Division

Community. Profile Anaconda- Deer Lodge County. Public Health and Safety Division Community Helth Profile 2015 Ancond- Deer Lodge County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12

More information

Supplementary Online Content

Supplementary Online Content Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern

More information

Community. Profile Lewis & Clark County. Public Health and Safety Division

Community. Profile Lewis & Clark County. Public Health and Safety Division Community Helth Profile 2015 Lewis & Clrk County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl

More information

Community. Profile Missoula County. Public Health and Safety Division

Community. Profile Missoula County. Public Health and Safety Division Community Helth Profile 2015 Missoul County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk

More information

Geographical influence on digit ratio (2D:4D): a case study of Andoni and Ikwerre ethnic groups in Niger delta, Nigeria.

Geographical influence on digit ratio (2D:4D): a case study of Andoni and Ikwerre ethnic groups in Niger delta, Nigeria. Journl of Applied Biosciences 27: 1736-1741 ISSN 1997 5902 Geogrphicl influence on digit rtio (2D:4D): cse study of Andoni nd Ikwerre ethnic groups in Niger delt, Nigeri. Gwunirem, Isrel U 1 nd Ihemelndu,

More information

EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE

EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE Swine Dy 21 EFFECTS OF INGREDIENT AND WHOLE DIET IRRADIATION ON NURSERY PIG PERFORMANCE J. M. DeRouchey, M. D. Tokch, J. L. Nelssen, R. D. Goodbnd, S. S. Dritz 1, J. C. Woodworth, M. J. Webster, B. W.

More information

ENERGY CONTENT OF BARLEY

ENERGY CONTENT OF BARLEY ENERGY CONTENT OF BARLEY VARIATION IN THE DIETARY ENERGY CONTENT OF BARLEY Shwn Firbirn, John Ptience, Hnk Clssen nd Ruurd Zijlstr SUMMARY Formultion of commercil pig diets requires n incresing degree

More information

Bioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM

Bioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM Bioctive milk components to secure growth nd gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM STSM Pigutnet FA1401 STSM 03/Septemer 30/Novemer/2017 (3 months) Host: Home: Thoms

More information

Community. Profile Carter County. Public Health and Safety Division

Community. Profile Carter County. Public Health and Safety Division Community Helth Profile 2015 Crter County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk

More information

Emerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data

Emerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data Emerging Options for Thromboprophylxis After Orthopedic Surgery: A Review of Clinicl Dt Bob L. Lobo, Phrm.D. In four rndomized, controlled studies of ptients undergoing orthopedic surgery, the ntithrombotic

More information

Supplementary Online Content

Supplementary Online Content Supplementry Online Content Rieckmnn N, Kronish IM, Shpiro PA, Whng W, Dvidson KW. Serotonin reuptke inhibitor use, depression, nd long-term outcomes fter n cute coronry : prospective cohort study. JAMA

More information

Invasive Pneumococcal Disease Quarterly Report. July September 2017

Invasive Pneumococcal Disease Quarterly Report. July September 2017 Invsive Pneumococcl Disese Qurterly Report July September 2017 Prepred s prt of Ministry of Helth contrct for scientific services by Rebekh Roos Helen Heffernn October 2017 Acknowledgements This report

More information

Precipitins and specific IgG antibody to

Precipitins and specific IgG antibody to 48 Thorx 1992;47:48-52 Precipitins nd specific IgG ntibody to Aspergillus fumigtus in chest unit popultion Deprtment of Immunology nd Osler Chest Unit, Churchill Hospitl, Oxford OX3 7LJ J A Fux D J Shle

More information

Opioid Use and Survival at the End of Life: A Survey of a Hospice Population

Opioid Use and Survival at the End of Life: A Survey of a Hospice Population 532 Journl of Pin nd Symptom Mngement Vol. 32 No. 6 December 2006 NHPCO Originl Article Opioid Use nd Survivl t the End of Life: A Survey of Hospice Popultion Russell K. Portenoy, MD, Un Sibircev, BA,

More information

HEMOGLOBIN STANDARDS*

HEMOGLOBIN STANDARDS* HEMOGLOBIN STANDARDS* RUSSELL L. HADEN Clevelnd Clinic, Clevelnd, Ohio Estimtions of hemoglobin often re unstisfctory to the lbortory worker nd the reports my be confusing to the clinicin. Unfortuntely,

More information

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :

PNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 : PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged

More information

Reports of cases of AIDS, HIV infection, and HIV/AIDS 1

Reports of cases of AIDS, HIV infection, and HIV/AIDS 1 Reports of cses of AIDS, HIV infection, nd HIV/AIDS 1 The HIV/AIDS Surveillnce Report is published nnully by the Division of HIV/AIDS Prevention Surveillnce nd Epidemiology, Ntionl Center for HIV, STD,

More information

pancreatic function Faecal chymotrypsin: a reliable index of exocrine

pancreatic function Faecal chymotrypsin: a reliable index of exocrine Archives of Disese in Childhood, 1988, 63, 785-789 Fecl chymotrypsin: relible index of exocrine pncretic function G A BROWN, D SULE, J WILLIAMS, J W L PUNTIS, I W BOOTH, AND A S McNEISH Institute of Child

More information

Estimating the impact of the 2009 influenza A(H1N1) pandemic on mortality in the elderly in Navarre, Spain

Estimating the impact of the 2009 influenza A(H1N1) pandemic on mortality in the elderly in Navarre, Spain Rpid communictions Estimting the impct of the influenz pndemic on mortlity in the elderly in Nvrre, Spin J Cstill (jcstilc@nvrr.es) 1, J Etxeberri 1, E Ardnz 1, Y Floristán 1, R López Escudero 1, M Guevr

More information

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer

CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn

More information

Measurement of Enzymatic Activity and by Radioimmunoassay

Measurement of Enzymatic Activity and by Radioimmunoassay CLIN. CHEM. 23/1, 95-99 (1977) Comprison of Humn Prosttic Acid Phosphtse by Mesurement of Enzymtic Activity nd by Rdioimmunossy Andrs G. Foti,1 Hrvey Herschmn,2 nd J. Fenimore Cooper3 We compred results

More information

Recall Bias in Childhood Atopic Diseases Among Adults in The Odense Adolescence Cohort Study

Recall Bias in Childhood Atopic Diseases Among Adults in The Odense Adolescence Cohort Study Syddnsk Universitet Recll Bis in Childhood Atopic Diseses Among Adults in The Odense Adolescence Cohort Study Mørtz, Chrlotte G; Andersen, Klus Ejner; Bindslev-Jensen, Crsten Published in: Act Dermto-Venereologic

More information

Hypertension, hyperinsulinaemia and obesity in middle-aged Finns with impaired glucose tolerance

Hypertension, hyperinsulinaemia and obesity in middle-aged Finns with impaired glucose tolerance Journl of Humn Hypertension (1998) 12, 265 269 1998 Stockton Press. All rights reserved 0950-9240/98 $12.00 ORIGINAL ARTICLE Hypertension, hyperinsulinemi nd obesity in middle-ged Finns with impired glucose

More information

Body mass index, waist-to-hip ratio, and metabolic syndrome as predictors of middle-aged men's health

Body mass index, waist-to-hip ratio, and metabolic syndrome as predictors of middle-aged men's health Originl Article - Sexul Dysfunction/Infertility pissn 2005-6737 eissn 2005-6745 Body mss index, wist-to-hip rtio, nd metbolic syndrome s predictors of middle-ged men's helth Jung Hyun Prk *, In-Chng Cho

More information

Fat intake in patients newly diagnosed with type 2 diabetes: a 4-year follow-up study in general practice

Fat intake in patients newly diagnosed with type 2 diabetes: a 4-year follow-up study in general practice Originl ppers Ft intke in ptients newly dignosed with type 2 dibetes: 4-yer follow-up study in generl prctice Floris A vn de Lr, Eloy H vn de Lisdonk, Peter L B J Lucssen, J M H Tigchelr, Sski Meyboom,

More information

The RUTHERFORD-2 trial in heterozygous FH: Results and implications

The RUTHERFORD-2 trial in heterozygous FH: Results and implications The RUTHERFORD-2 tril in heterozygous FH: Results nd implictions Slide deck kindly supplied s n eductionl resource by Professor Derick Rl MD PhD Crbohydrte & Lipid Metbolism Reserch Unit University of

More information

Feeding state and age dependent changes in melaninconcentrating hormone expression in the hypothalamus of broiler chickens

Feeding state and age dependent changes in melaninconcentrating hormone expression in the hypothalamus of broiler chickens Supplementry Mterils Epub: No 2017_23 Vol. 65, 2018 https://doi.org/10.183/bp.2017_23 Regulr pper Feeding stte nd ge dependent chnges in melninconcentrting hormone expression in the hypothlmus of broiler

More information

Metabolic Syndrome and Health-related Quality of Life in Obese Individuals Seeking Weight Reduction

Metabolic Syndrome and Health-related Quality of Life in Obese Individuals Seeking Weight Reduction Metbolic Syndrome nd Helth-relted Qulity of Life in Obese Individuls Seeking Weight Reduction Adm Gilden Tsi 1, Thoms A. Wdden 1, Dvid B. Srwer 1, Robert I. Berkowitz 1, Leslie G. Womble 1, Louise A. Hesson

More information

in human duodenal aspirate'

in human duodenal aspirate' Gut, 197, 11, 859-866 The interreltionships of pncretic enymes in humn duodenl spirte' D M GOLDBERG ND K G WORMSLEY From the Royl Hospitl nd Royl Infirmry, Sheffield SMMRY The interreltionships of proteolytic

More information

Prognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic

Prognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic Crcinogenesis, 2015, Vol. 36, No. 2, 243 248 doi:10.1093/crcin/bgu247 Advnce Access publiction December 18, 2014 Originl Mnuscript originl mnuscript Prognostic significnce of pretretment serum levels of

More information

Trends in antihypertensive and lipidlowering therapy in subjects with type II diabetes: clinical effectiveness or clinical discretion?

Trends in antihypertensive and lipidlowering therapy in subjects with type II diabetes: clinical effectiveness or clinical discretion? ORIGINAL ARTICLE Trends in ntihypertensive nd lipidlowering therpy in subjects with type II dibetes: clinicl effectiveness or clinicl discretion? MC Gulliford, J Chrlton nd R Ltinovic Deprtment of Public

More information

BODY OF REPORT. SEAT0 Medic Study No. 4. Serologic Response to Tha.i Hemorrha.gic Fever Virus Infection. Project No.

BODY OF REPORT. SEAT0 Medic Study No. 4. Serologic Response to Tha.i Hemorrha.gic Fever Virus Infection. Project No. BODY OF REPORT SEAT Medic Study No. 4 Project No. 3A 2561 A 811 Tsk 1: Serologic Response to Th.i Hemorrh.gic Fever Virus Infection Mi1it.q Medicl Reserch Prgr.m S. E. Asi. Mi1it.r~ Medic.1 Rese.rch Prgr.m

More information

The Effects of Diet Particle Size on Animal Performance

The Effects of Diet Particle Size on Animal Performance MF-2050 Feed Mnufcturing Feed Mnufcturing Cerel grins re the primry energy source in swine nd poultry diets. Therefore, not only must producers be concerned bout the composition of the grin, but lso how

More information

msmr MEDICAL SURVEILLANCE MONTHLY REPORT INSIDE THIS ISSUE: A publication of the Armed Forces Health Surveillance Center Summary tables and figures

msmr MEDICAL SURVEILLANCE MONTHLY REPORT INSIDE THIS ISSUE: A publication of the Armed Forces Health Surveillance Center Summary tables and figures VOL. 17 NO. 09 SEPTEMBER 2010 msmr A publiction of the Armed Forces Helth Surveillnce Center MEDICAL SURVEILLANCE MONTHLY REPORT Source: CDC INSIDE THIS ISSUE: Contct trnsfer of vccini virus from U.S.

More information

The Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes

The Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes Originl Article doi: 10.4093/kdj.2010.34.3.166 pissn 1976-9180 eissn 2093-2650 The Effects of Smll Sized Rice Bowl on Crbohydrte Intke nd Dietry Ptterns in Women with Type 2 Dibetes Hee-Jung Ahn 1, *,

More information

One of the most important biological mechanisms of

One of the most important biological mechanisms of Brief Report Serum Thymidine Kinse 1 Activity in the Prognosis nd Monitoring of Chemotherpy in Lung Cncer Ptients: A Brief Report Benjmin Nismn, PhD,* Hovv Nechushtn, MD, PhD,* Him Birn, MD, Hds Gntz-Sorotsky,

More information

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE

EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.

More information

A community-based comparison of trauma patient outcomes between D- and L-lactate fluids,

A community-based comparison of trauma patient outcomes between D- and L-lactate fluids, Americn Journl of Emergency Medicine (2013) 31, 206 214 www.elsevier.com/locte/jem Originl Contribution A community-bsed comprison of trum ptient outcomes between D- nd L-lctte fluids, Kzuki Kuwbr PhD,,

More information

Evaluation of the TEST 1 erythrocyte sedimentation rate system and intra- and inter-laboratory quality control using new latex control materials

Evaluation of the TEST 1 erythrocyte sedimentation rate system and intra- and inter-laboratory quality control using new latex control materials Clin Chem Lb Med 2010;48(7):1043 1048 2010 by Wlter de Gruyter Berlin New York. DOI 10.1515/CCLM.2010.162 Evlution of the TEST 1 erythrocyte sedimenttion rte system nd intr- nd inter-lbortory qulity control

More information

URINARY incontinence is an important and common

URINARY incontinence is an important and common Urinry incontinence in older people in the community: neglected problem? Helen Stoddrt, Jenny Donovn, Elise Whitley, Deborh Shrp nd In Hrvey SUMMARY Bckground: The prevlence nd impct of urinry incontinence

More information

THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS

THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS John F. Ptience nd Doug Gillis SUMMARY

More information

brane teichoic acids are believed to be present in many

brane teichoic acids are believed to be present in many JOURNL OF CLINICL MICROBIOLOGY, June 1989, p. 1286-1291 95-1137/89/61286-6$2./ Copyright 1989, mericn Society for Microbiology Vol. 27, No. 6 ntibodies to Stphylococcl Peptidoglycn nd Its Peptide Epitopes,

More information

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:

Original Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract: Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute

More information

The accuracy of creatinine clearance with and without

The accuracy of creatinine clearance with and without Postgrd Med J (1991) 67, 42-46 ) The Fellowship of Postgrdute Medicine, 1991 The ccurcy of cretinine clernce with nd without urine collection s mesure of glomerulr filtrtion rte D.G. Wller,' J.S. Fleming,2

More information

Original Article Serum tumor markers used for predicting esophagogastric junction adenocarcinoma in esophageal malignancy

Original Article Serum tumor markers used for predicting esophagogastric junction adenocarcinoma in esophageal malignancy Int J Clin Exp Med 2016;9(6):11859-11864 www.ijcem.com /ISSN:1940-5901/IJCEM0025330 Originl Article Serum tumor mrkers used for predicting esophgogstric junction denocrcinom in esophgel mlignncy Yongkng

More information

A Comparison of Serum Magnesium Level in Pregnant Women with and without Gestational Diabetes Mellitus (GDM)

A Comparison of Serum Magnesium Level in Pregnant Women with and without Gestational Diabetes Mellitus (GDM) Brief Report J Bbol Univ Med Sci Vol 18, Issu 12; Dec 2016. P:71-75 A Comprison of Serum Mgnesium Level in Pregnnt Women with nd without Gesttionl Dibetes Mellitus (GDM) Z. Bouzri (MD) 1, F. Elmi(MD) 2,

More information

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients

Effects of physical exercise on working memory and prefrontal cortex function in post-stroke patients Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei

More information

Analysis of Risk Factors for the Development of Incisional and Parastomal Hernias in Patients after Colorectal Surgery

Analysis of Risk Factors for the Development of Incisional and Parastomal Hernias in Patients after Colorectal Surgery Originl Article Journl of the Koren Society of J Koren Soc Coloproctol 2012;28(6):299-303 http://dx.doi.org/10.3393/jksc.2012.28.6.299 pissn 2093-7822 eissn 2093-7830 Anlysis of Risk Fctors for the Development

More information

Extraction and Some Functional Properties of Protein Extract from Rice Bran

Extraction and Some Functional Properties of Protein Extract from Rice Bran Ksetsrt J. (Nt. Sci.) 40 : 209-214 (2006) Extrction nd Some Functionl Properties of Protein Extrct from Rice Brn Chockchi Theerkulkit*, Siree Chiseri nd Siriwt Mongkolknchnsiri ABSTRACT Rice brn protein

More information

A survey of atrial fibrillation in general practice: the West Birmingham Atrial Fibrillation Project

A survey of atrial fibrillation in general practice: the West Birmingham Atrial Fibrillation Project Originl ppers A survey of tril fibrilltion in generl prctice: the West Birminghm Atril Fibrilltion Project GREGORY Y H LIP DANIEL J GOLDING MASOOD NAZIR D GARETH BEEVERS DAVID L CHILD R IAN FLETCHER SUMMARY

More information

BMI and Mortality: Results From a National Longitudinal Study of Canadian Adults

BMI and Mortality: Results From a National Longitudinal Study of Canadian Adults nture publishing group BMI nd Mortlity: Results From Ntionl Longitudinl Study of Cndin Adults Hether M. Orpn 1, Jen-Mrie Berthelot 2,3, Mrk S. Kpln 4, Dvid H. Feeny 5,6, Bentson McFrlnd 7 nd Nncy A. Ross

More information

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV

XII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies

More information

(Received for publication February 17, 1944) Since, as has been demonstrated by Enders (3),

(Received for publication February 17, 1944) Since, as has been demonstrated by Enders (3), CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XII. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PREVENTION

More information

A Two-Stage Sampling Method for Clinical Surveillance of Individuals in Care for HIV Infection in the United States

A Two-Stage Sampling Method for Clinical Surveillance of Individuals in Care for HIV Infection in the United States Reserch Articles A Two-Stge Smpling Method for Clinicl Surveillnce of Individuls in Cre for HIV Infection in the United Sttes Ptrick S. Sullivn, DVM, PhD John M. Kron, PhD Fye E. Mlitz, MPH b Stephnie

More information

Mycobacterial Ribonucleic Acid Preparations

Mycobacterial Ribonucleic Acid Preparations INFEcriON AND IMMUNITY, JUlY 1973, p. 42-47 Vol. 8, No. 1 Copyright 0 1973 Americn Society for Microbiology Printed in U.S.A. Reltionship Between Tuberculin Hypersensitivity nd Cellulr Immunity to Infection

More information

Urinary Tract Infection in Men

Urinary Tract Infection in Men C H A P T E R 1 9 Urinry Trct Infection in Men Toms L. Griebling, MD Associte Professor & Vice Chir of Urology University of Knss Knss City, Knss Contents INTRODUCTION........................................623

More information

CME/SAM. Study on Hyperuricemia in HBV-Associated Glomerulonephritis

CME/SAM. Study on Hyperuricemia in HBV-Associated Glomerulonephritis AJCP / Originl Article Study on Hyperuricemi in HBV-Associted Glomerulonephritis Yongze Zhung, MD, PhD, 1 Yingho Yu, MD, PhD, 2 Yingfng Hung, MD, 3 nd Xiorong Zhong, MD 1 From the 1 Deprtment of Nephrology,

More information

Global Intellectual Deficits in Cystinosis

Global Intellectual Deficits in Cystinosis Americn Journl of Medicl Genetics 49:83-87 (1994) Globl Intellectul Deficits in Cystinosis Brbr L.H. Willims, Jerry A. Schneider, nd Doris A. Truner Deprtments of Neurosciences (B.L.H.W.. D.A.T.) nd Peditrics

More information

Lipase Activity in Albino Rats Treated with an Antimalarial Drug

Lipase Activity in Albino Rats Treated with an Antimalarial Drug ISSN: 2347-3215 Volume 3 Number 11 (November-2015) pp.73-78 www.ijcrr.com Lipse Activity in Albino Rts Treted with n Antimlril Drug K. N. Agbfor* Deprtment of Biochemistry, Ebonyi Stte University, Abkliki,

More information

EXPERIMENTAL AND THERAPEUTIC MEDICINE 5: 89-94, 2013

EXPERIMENTAL AND THERAPEUTIC MEDICINE 5: 89-94, 2013 EXPERIMENTAL AND THERAPEUTIC MEDICINE 5: 89-94, 2013 Combined nlysis of serum γ-glutmyl trnsferse isoenzyme II, α-l-fucosidse nd α-fetoprotein detected using commercil kit in the dignosis of heptocellulr

More information

Risk of Colorectal Cancer by Subsite in a Swedish Prostate Cancer Cohort

Risk of Colorectal Cancer by Subsite in a Swedish Prostate Cancer Cohort Specil Report Risk of Colorectl Cncer by Subsite in Swedish Prostte Cncer Cohort Yunxi Lu, MD, PhD, Rickrd Ljung, MD, PhD, Ann Mrtling, MD, PhD, nd Mts Lindbld, MD, PhD Bckground: The reltionship between

More information

THE EXPERIMENTAL USE OF LIPOCAIC IN THE TREATMENT OF PSORIASIS A PRELIMINARY REPORT1,2

THE EXPERIMENTAL USE OF LIPOCAIC IN THE TREATMENT OF PSORIASIS A PRELIMINARY REPORT1,2 THE EXPERIMENTAL USE OF LIPOCAIC IN THE TREATMENT OF PSORIASIS A PRELIMINARY REPORT1,2 C. DUNCAN STEWART, M.D., D. E. CLARK, M.S., M.D., L. R. DRAGSTEDT, PH.D., M.D. AND S. WILLIAM BECKER, M.S., M.D. (Received

More information

WSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265;

WSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265; FINAL REPORT WTFRC Project # AH-1-5 WSU Project # 13C-355-3 Project title: PI: Orgniztion: Coopertors: of Sunburn in Apples with RAYNOX Lrry Schrder, Horticulturist WSU Tree Fruit Reserch nd Extension

More information

General Microscopic Changes

General Microscopic Changes Generl Microscopic Chnges 2 This chpter covers collection of microscopic chnges tht lck dignostic specificity ut occur in different specific diseses, s will ecome pprent in susequent chpters. Almost ll

More information

Authors: Ms. Joanne Cassar, Ms. Natasha Sindicich and Dr. Lucy Burns, National Drug and Alcohol Research Centre, University of New South Wales.

Authors: Ms. Joanne Cassar, Ms. Natasha Sindicich and Dr. Lucy Burns, National Drug and Alcohol Research Centre, University of New South Wales. ecstsy nd relted drug trends july bulletin Authors: Ms. Jonne Cssr, Ms. Ntsh Sindicich nd Dr. Lucy Burns, Ntionl Drug nd Alcohol Reserch Centre, University of New South Wles. Suggested Cittion: Cssr, J.,

More information

Identification and Quantitation of the

Identification and Quantitation of the APPLIED MICROBIOLOGY, My 1972, p. 946-950 Copyright i 1972 Americn Society for Microbiology Vol. 23, No. 5 Printed in USA. Identifiction nd Quntittion of the Components of Polyvlent Inctivted Influenz

More information

University of Texas Health Science Center, San Antonio, San Antonio, Texas, USA

University of Texas Health Science Center, San Antonio, San Antonio, Texas, USA Lung Cncer Chemotherpy Given Ner the End of Life by Community Oncologists for Advnced Non-Smll Cell Lung Cncer Jose R. Murillo, Jr., Jim Koeller b,c Methodist Hospitl, Houston, Texs, USA; b University

More information

Effects of age, density, and seasonality on molt pattern in the mammal genus (Peromyscus)

Effects of age, density, and seasonality on molt pattern in the mammal genus (Peromyscus) University of New Hmpshire University of New Hmpshire Scholrs' Repository Honors Theses nd Cpstones Student Scholrship Spring 2015 Effects of ge, density, nd sesonlity on molt pttern in the mmml genus

More information

Plasma histamine and catecholamines in stable asthmatic subjects

Plasma histamine and catecholamines in stable asthmatic subjects Clinicl Science (1982) 62,661-665 66 1 Plsm histmine nd ctecholmines in stble sthmtic subjects P. J. BARNES, P. W. IND AND M. J. BROWN Deprtments of Medicine nd Clinicl Phrmcology, Royl Postgrdute Medicl

More information

Journal of Hainan Medical University 2017; 23(2): Journal of Hainan Medical University.

Journal of Hainan Medical University 2017; 23(2): Journal of Hainan Medical University. Journl of Hinn Medicl University 2017; 23(2): 151-155 151 Journl of Hinn Medicl University http://www.hnykdxxb.com Reltionship between DEXA bone minerl density mesurement results nd serum cytokines s well

More information

Single-Molecule Studies of Unlabelled Full-Length p53 Protein Binding to DNA

Single-Molecule Studies of Unlabelled Full-Length p53 Protein Binding to DNA Single-Molecule Studies of Unlbelled Full-Length p53 Protein Binding to DNA Philipp Nuttll, 1 Kidn Lee, 2 Pietro Ciccrell, 3 Mrco Crminti, 3 Giorgio Ferrri, 3 Ki- Bum Kim, 2 Tim Albrecht 1* 1 Imperil College

More information

Significance of Expression of TGF- in Pulmonary Metastasis in Non-small Cell Lung Cancer Tissues

Significance of Expression of TGF- in Pulmonary Metastasis in Non-small Cell Lung Cancer Tissues Originl Article Significnce of Expression of in Pulmonry Metstsis in Non-smll Cell Lung Cncer Tissues Hisshi Sji, Hruhiko Nkmur, Idiris Awut, Norihito Kwski, Msru Hgiwr, Akihiko Ogt, Mkoto Hosk, Tkmoto

More information

BIOSTATISTICS. Lecture 1 Data Presentation and Descriptive Statistics. dr. Petr Nazarov

BIOSTATISTICS. Lecture 1 Data Presentation and Descriptive Statistics. dr. Petr Nazarov Microrry Center BIOSTATISTICS Lecture 1 Dt Presenttion Descriptive Sttistics dr. Petr Nzrov 25-02-2011 petr.nzrov@crp-snte.lu Lecture 1. Dt presenttion descriptive sttistics COURSE OVERVIEW Orgniztion

More information

Abnormalities of total serum magnesium concentration

Abnormalities of total serum magnesium concentration J Vet Intern Med 2002;16:217 221 Prevlence nd Incidence of Serum Mgnesium Anormlities in Hospitlized Cts Jeffrey Toll, Hollis Er, Nichole Birnum, nd Thoms Schermerhorn Totl serum mgnesium concentrtion

More information

Clinical manifestations in patients with alpha-fetoprotein producing gastric cancer

Clinical manifestations in patients with alpha-fetoprotein producing gastric cancer Curr Oncol, Vol. 21, pp. e394-399; doi: http://dx.doi.org/10.3747/co.21.1768 CLINICAL MANIFESTATIONS IN AFP PRODUCING GASTRIC CANCER ORIGINAL ARTICLE Clinicl mnifesttions in ptients with lph-fetoprotein

More information

Using proliferative markers and Oncotype DX in therapeutic decision-making for breast cancer: the B.C. experience

Using proliferative markers and Oncotype DX in therapeutic decision-making for breast cancer: the B.C. experience ORIGINAL ARTICLE Using prolifertive mrkers nd Oncotype DX in therpeutic decision-mking for brest cncer: the B.C. experience E. Bxter bsc,* L. Gondr btech pdc, C. Lohrisch md, S. Chi md, K. Gelmon md, M.

More information

Analysis of Regulatory of Interrelated Activity of Hepatocyte and Hepatitis B Viruses

Analysis of Regulatory of Interrelated Activity of Hepatocyte and Hepatitis B Viruses Interntionl Journl of Biomedicl Mterils Reserch 8 6(): -7 http://www.sciencepublishinggroup.com/j/ijbmr doi:.648/j.ijbmr.86. ISSN: 33-756 (Print) ISSN: 33-7579 (Online) Anlysis of Regultory of Interrelted

More information

Evaluation of New Urinary Tract Infection Screening Devices

Evaluation of New Urinary Tract Infection Screening Devices APPLIED MICROBIOLOGY, Aug. 1973, p. 196-201 Copyright 0 1973 Americn Society for Microbiology Vol. 26, No. 2 Printed in U.S.A. Evlution of New Urinry Trct Infection Screening Devices WILLIAM A. CRAIG,

More information

Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population

Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population Originl Article Clinicl sttistics nlysis on the chrcteristics of pneumoconiosis of Chinese miner popultion Mei-Fng Wng 1 *, Run-Ze Li 2 *, Ying Li 2, Xue-Qin Cheng 1, Jun Yng 1, Wen Chen 3, Xing-Xing Fn

More information

STATISTICAL DATA ANALYSIS IN EXCEL

STATISTICAL DATA ANALYSIS IN EXCEL Microrry Center STATISTICAL DATA ANALYSIS IN EXCEL Prt 1 Introduction to Sttistics Dr. Petr Nzrov 14-06-2010 petr.nzrov@crp-snte.lu Sttisticl dt nlysis in Excel COURSE OVERVIEW Objectives The course: Reminds

More information