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1 Chapter 8 Outline: Haloalakanes, Halogenation, & Radical reactions Cover on your own 1. Halogenation of Alkanes A. Mechanism of Halogenation B. Regioselectivity & Stereoselectivity of Halogenation 2. Radical Autoxidation, Antioxidants & Free Radical Inhibitors 3. Radical Addition of HBr to Alkenes Suggested homework problems: 8.8, 8.13, , We will learn to halogenate alkanes in a regioselective and stereoselective manner. Once you know how to halogenate alkanes you will use alkyl halides to make other functional groups in substitution and elimination reactions in chapter 9. Page 1 of 15
2 1. Halogenation of Alkanes to Prepare RX Halogenation of alkanes with Br 2 and Cl 2 is very common. (Reaction with F 2 is too violent, and reaction with I 2 is too slow to be extremely useful.) Example Halogenation reaction: NBS, h Br OR CCl 4,RT This is a substitution reaction, where a halogen substitutes a hydrogen. Conditions for Halogenation: 1. X 2 and hν (or high heat), OR 2. NBS (N-bromosuccinimide) in CCl 4 at RT (NCS also exists) for allyl halides O N Br (243 kj/mol) N Cl (200 kj/mol) NBS = N Br Br Br (193 kj/mol) Cl Cl (239 kj/mol) O Page 2 of 15
3 A. Mechanism of Radical Halogenation Radical chain mechanism = intermediates are formed by homolytic cleavage of bonds to form radical species. Radical halogenation occurs in three steps: 1. Initiation reactions that produce radicals 2. Propagation reactions where radical form more radicals 3. Termination reactions that terminate radicals 1. Initiation: Cl Cl hν Cl Cl A radical X, once formed, rapidly reacts a σ-bond. Some compounds cleave rather easily by homolytic cleavage: CH 3 CH 2 O OCH 2 CH 3 80 o C CH 3 CH 2 O OCH 2 CH 3 o Energy for bond cleavage can be supplied by light or heat o λ = nm provides 585 kj to 167 kj/mol o peroxides have BDE = kj/mol, hence peroxides are often used as radical initiators o benzoyl peroxide is another common initiator: Page 3 of 15
4 2. Propagation: (CH 3 ) 3 C H Cl (CH 3 ) 3 C HCl (CH 3 ) 3 C Cl Cl (CH 3 ) 3 C Cl Cl 3. Termination: Cl Cl Cl Cl (CH 3 ) 3 C C(CH 3 ) 3 (CH 3 ) 3 C C(CH 3 ) 3 (CH 3 ) 3 C Cl (CH 3 ) 3 C Cl In reality, if more than one hydrogen is present, the starting material will keep reacting with more X. Page 4 of 15
5 B. Regioselectivity & Stereoselectivity in Halogenation The following reaction is regioselective. Regioselectivity is 3 > 2 > 1. for bromination, approximately 1600:80:1 for chlorination, approximately 5:4:1 How do you explain the following outcome of the reaction in 2-methylbutane? 1 st compare possible intermediates: Why does the following reaction occur as it does? Br Br 2,h Which free radical is more stable? What dictates the major product? Page 5 of 15
6 Allylic = Benzylic = Based on BDE and resonance, one can conclude that an allylic radical is even more stable than a 3 o carbon radical. Most times the most stable radical leads to the major product! The trick is finding the hydrogen that has the weakest BDE to yield the most stable intermediate. Page 6 of 15
7 Practice questions: Homolytic bond cleavage. For the steroid below, place the following protons in order of HOMOLYTIC bond dissociation energy AND provide descriptions for the TYPES of each proton (e.g. 1 o alkyl or 1 o allyl, etc.). Ha = O Hb Hc Hd He Hb= Hc = Hd = Ha He = Highest in bond energy > > > > Using the appropriate type of arrows, show both homolytic and heterolytic bond cleavage below and provide the products below. Homolytic bond cleavage: H 3C H Heterolytic bond cleavage: H 3C H Page 7 of 15
8 Chlorination vs. bromination Although alkanes undergo radical substitutions with both Cl 2 and Br 2, chlorination and bromination exhibit two important differences. 1. Chlorination is faster than bromination. 2. Chlorination is unselective compared to bromination. Page 8 of 15
9 What about stereoselectivity of radicals? Compare: C C Radical halogenation reactions give racemic mixtures of products if chiral products are possible. For example, butane itself is not chiral, but reaction at the secondary carbon provides a chiral product, 2-bromobutane. Page 9 of 15
10 Draw the monobromination product(s) for the following reactions. Page 10 of 15
11 2. Radical Autoxidation Oxidation of lipids occurs through radical reactions, called auto-oxidation. Oils are susceptible to allylic free radical oxidation by O 2. Auto-oxidation of fatty acids occur at the allylic sites: Page 11 of 15
12 Antioxidants inhibiting unwanted free radical reactions Free radicals arise normally during human metabolism. o Sometimes the body s immune system s cells purposefully create them to neutralize viruses and bacteria. o Environmental factors such as pollution, radiation, cigarette smoke and herbicides can also breed free radicals. o The body has inherent mechanisms to handle free radicals. o BUT if antioxidants are unavailable, or if the free-radical production becomes excessive, damage can occur. o As you may know, free radical damage accumulates with age. Free Radical Inhibitors are added to many consumer products to stop products from degrading via radical mechanisms. o Vitamin E and BHT (butylated hydroxytoluene) re most common food additives. They act as a sacrificial reactant. What intermediate is formed? Page 12 of 15
13 Natural Antioxidants e.g. Vitamin E & Vitamin C water and fat soluble antioxidants They both act as scavengers, helping to prevent cell and tissue damage that could lead to cellular damage and disease. Bioflavonoids - Naturally Occurring Phenols: Over 5000 naturally occurring flavonoids have been characterized from various plants and classified according to their chemical structure. B A The skeleton above can be represented as the C 6 - C 3 - C 6 system. Flavonoids are: o Plant pigments that lend flowers and herbs their yellow, orange and red color. o Found in fruits, vegetables and processed plant derived foods like tea, wine, chocolate (esp. dark chocolate). o Lend the beneficial effects of fruits and vegetables o These benefits include: o Anti-inflammatory, anti-allergic, anti-cancer activity, improved blood flow and cardiovascular diseases, antioxidant properties Page 13 of 15
14 Bioflavanoids Quercetin is a flavonoid (flavonol), found in citrus fruit, buckwheat and onions. Quercetin is thought to help to prevent some types of cancer, Quercetin Epicatechin improves blood flow and helps improve cardiac health. Cocoa, the major ingredient of dark chocolate, contains relatively high amounts of epicatechin and has been found to have nearly twice the antioxidant content of red wine and up to three times that of green tea. Epicatechin Page 14 of 15
15 3. Radical Addition of HBr to Alkenes Addition of HBr to alkenes gives either Markovnikov addition or non- Markovnikov addition depending on reaction conditions. Markovnikov addition occurs when radicals are absent. non-markovnikov addition occurs when peroxides or other sources of radicals are present. Page 15 of 15
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