PI3K-Akt-mTOR Pathway, Flyer

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1 PI3K-Akt-mTOR Pathway, Flyer Interest in any of the products, request or order them at Bio-Connect. Bio-Connect B.V. T NL +31 (0) T BE +32 (0) Begonialaan 3a F NL +31 (0) F BE +32 (0) TE issen E info@bio-connect.nl The Netherlands W

2 四叫血也.樹 GeneTex Your Expertise, Our Antibodies, Accelerated Discovery. PI3K-Akt-mTOR 之 J Pathway lnk Signaling G 刮Uw' 個muPAW asse FEm--2' NFKB Signaling,l Cardiovascular Homeostasis 圖 在 '~ 可 ~ Kinase Synaptic Signaling Phosphatase Neuroprotection Neurodegeneration Transcription Factor cascade Cytosolic Sequestration \ij ;53 1 I Oegradation Apoptosis / 申 ~ Death Gene Repression cellco._. ~"';"al Survival Gene Expression -'^' 恥, 有 N P >>'" / d P ~ 旬 F S R- Q Akt, also known as protein kinase B (PKB), is a serine/threonine kinase that plays an important role in oncogenesis and the cellular processes of metabolism, apoptosis and autophagy. After being recruited to the plasma membrane by P1P3, Akt is activated through phosphorylation of either T308 or 8473 by an activating kinase. The availability of P1P3 at the plasma membrane is tightly regulated by the opposing actions of PI 3-Kinase (PI3K), which phosphorylates P1P2 to P1P3, and PTEN, which dephosphorylates P1P3 and abrogates Akt recruitment. The constitutive activation of PI3K and the loss of PTEN function are both associated with oncogenic progression. The mammalian target of rapamycin (mtor) has been identified as the critical downstream mediator of Akt's oncogenic properties. The mtorc1 complex, composed of mtor, GßL, Raptor and PRA840 induces cell growth by stimulating protein synthesis, driving cell cycle progression and inhibiting autophagy. mtor can also associate with different proteins to form the functionally distinct complex, rapamycin-insensitive mtorc2. It has recentiy been discovered that mtorc2 directiy phosphorylates and activates Akt, indicating that mtor plays key roles both upstream and downstream of Akt. GeneTex is proud to 0 仟 ér a complete line of antibodies for studying the various components of the PI3K-Akt-mTOR signaling pathway.

3 PI3K & PTEN 區軍區 r:m. E 區函 ~ 加 UUï I:r: I~ fiji1fiilillliiíj GTX61312 PI3Kp110 口 antibody [EP383Y[ ICC/IF, IP, PI3K p110 口 GTX25453 PI3K p100 口 antibody ELl SA, IHC-F, IHC-P, GTX89196 PI3K p11 Oa antibody GtpAb, Ms, Cow, Oog, Rat ELl SA, IHC PI3K p110 日 GTX61226 PI3K p110ß antibody [Y384] FACS, IP, GTX59597 PI3K p11 Oß antibody ELl SA, IHC, PI3K p110y GTX61238 PI3K p11 Oy antibody [Y388] FACS, IP, GTX89900 PI3K p11 Oy antibody GtpAb, Ms, Oog ELl SA, PI3K p1100 GTX61208 PI3K p11 00 antibody [Y387] ICC/IF, IP, GTX21678 PI3K p11 00 antibody ELl SA, ICC/l F, GTX61304 PI3K p85 口 antibody [EP380Y], Rat FACS, ICC/l F, IHC-P, IP, PI3K p85 口 GTX81224 PI3K p85a antibody IHC, GTX39409 PI3K p85 口 antibody [U5] Ms mab, Ms, Cow, Mk, Rat IHC-Fr, IP, PI3K p85ß GTX PI3K p85ß antibody PI3K p85 GTX50873 PI3K p85 口 1 yl ß antibody. Ms. Rat IHC-P 口 + 自 +y GTX50858 PI3K p85 (phospho Tyr467) antibody. Ms. Rat GTX PI3K p150 antibody PI3K p150 GTX63620 PI3K p150 antibody [EPR5303(2)]. Ms. Rat FACS, ICC/l F, IHC, GTX25459 PI3K p150 antibody ELl SA, IHC-F, IHC-P, PI3K p101 GTX PI3K p101 antibody IHC-P PI3K C2 口 GTX PI3K C2 口 antibody ICC/IF, GTX89716 PI3K C2 口 antibody GtpAb, Ms, Oog ELl SA, IHC Vps34 GTX PI3K class 31 Vps34 antibody GTX25451 PI3K class 31 Vps34 antibody ELl SA, IHC-F, IHC-P, GTX PTEN antibody. Ms ICC/IF, GTX50411 PTEN antibody. Ms. Rat IHC, PTEN GTX83304 PTEN antibody [1 B8] Ms mab. Ms ELl SA, FACS, ICC/l F, GTX61780 PTEN (phospho Thr366/Ser370) [EP229] antibody ICC/IF, IHC, IP, GTX38637 PTEN (phospho Ser380/Thr382/Thr383) antibody. Ms. Rat ICC/IF, IHC-P, GTX13590 PTEN phospho S385 antibody. Ms. Rat nu-71 < 4u 43 82: (; ) A鬥a-nunu PI3K p85ß antibody (GTXI 1l689): PI3K piol antibody (GTXI078I3): analysis of (A) Jurkat and IHC-P analysis of normal human (B) Raji cell Iysates. esophagus tissue calyculina PTEN PTEN (phospho Ser380 /Thr382/ Thr383) antibody (GTX38637): analysis of extract from HT29 cells untreated or treated with calyculin A Selecetd Application Reference PTEN antibody (GTX101025) ang, A. M. et al. (2011) Biochem Pharmacol. Akt I PKB cm~ 回回昂揖訪問由 iilii1 咽囡囡囡圓, Il 軍 m 喧 fj.'.uj'l 1..!fiJi1fIilillliIíJ Akt GTX Akt1 1 Akt2 1 Akt3 antibody. Ms. Rat. IHC GTX28805 Akt antibody. Ms. Rat CC, ELlSA, ICC/IF, IHC-P, IP, GTX Akt1 antibody ICC/IF, IHC-P, Akt1 GTX50648 Akt1 antibody. Ms. Rat ICC/IF, IHC, GTX62493 Akt1 antibody [M 1843] Ms mab GTX Ak 位 antibody Akt2 GTX50494 Ak 位 Antibody. Ms. Rat IHC, GTX83257 Ak 位 antibody [1 B6] Ms mab, Mk, Rat ELl SA, ICC/l F, GTX84908 Ak 位 antibody [4H7] Ms mab FACS, ICC/l F, IHC, Akt3 GTX Akt3 antibody. Ms. Rat ICC/IF, GTX84905 Akt3 antibody [9H8] Ms mab. Ms ICC/IF, IHC, GTX50869 Akt1 1 Akt2 1 Akt3 (phospho Tyr315/316/312) antibody. Ms. Rat ICC/IF, IHC, Phospho-Akt GTX28933 Akt (phospho Thr308) antibody. Ms ELl SA, GTX79150 Akt (phospho Thr308) antibody ICC/IF, IHC, GTX50339 Akt1 (phospho Th 叫 50) Antibody. Ms. Rat ICC/IF, IHC, Your Expertise Our Antibodies Accelerated Discovery

4 Akt I PKB Akt (phospho Ser473) antibody Akt1 (phospho Ser473) antibody [104A28 月 AK 位 (phospho Ser474) antibody Ms mab, Ms, Ms, Rat ICC/l F, IP, IHC-P, A B 250 一 AKT1 ot450 GTX62621 MW KD 一 K ua 一 一 的一 Phospho-AKT Selecetd Application Reference Akt (phospho Thr308) antibody (GTX28933) Akt1 (phospho 5er473) antibody [104A282] (GTX11901) Matsuda, N. et al. (2007) Ca rd 的 vasc Res 76: (; Ms) Akt1 (phospho Thr308) antibody Akt1 (phospho Thr450) antibody Akt1 (phospho Ser473) antibody IEP2107YI (GTX61798): IEPR41571 (GTX62621): [104A 到 821 (GTX1l901): analysis of (A) untreated and analysis of (A) untreated and analysis of (1) untreated and (B) PDGF-treated NIH3T3 celllysates. (B) ^ phosphatase-treated NIH3T3 (2) PDGF-treated NIH3T3 celllysates celllysates Substrates of Akt Cell Survival via Gene Regulation 廬山區恥, 向 z 耐幽幽 r:l!li 咽.ur. 1:r:1! GTX38667 AR (phospho Ser213) antibody GTX50126 CREB (phospho Ser133) antibody GTX50179 Fox01 (phospho Ser256) antibody. Ms. Rat GTX50196 Fox01 (phospho Ser319) antibody. Ms GTX79072 Fox03A (phospho Ser253) antibody. Ms. Rat GTX50197 Fox04 (phospho Ser197) antibody. Ms. Rat GTX50357 MDM2 (phospho Ser166) antibody GTX21094 MDM2 (phospho Ser185) antibody. Ms GTX50136 Bad (phospho Ser136) antibody Ms Cell Survival GTX38680 Bad (phospho Ser136) antibody. Ms. Rat via Apoptosis GTX85616 PDCD4 (phospho Ser457) antibody. Ms. Rat Repression GTX48645 PDCD4 (phospho Ser457) antibody [2E10.C12] Ms mab. Ms. Ral. XI Proliferation GTX18032 PEA 15 (phospho Ser116) antibody. Ms. Rat GTX50140 ERa (phospho Ser167) antibody. Ms GTX38649 GATA1 (phospho Ser310) antibody. Ms. Rat GTX62233 p21cip1 (phospho Ser145) antibody [EP1138]. Ms. Rat GTX50247 p21cip1 (phospho Thr145) antibody GTX50343 elf4b (phospho Ser422) antibody. Ms GTX50258 mtor (phospho Ser2448) antibody GTX79009 mtor (phospho Ser2448) antibody. Ms. Rat Protein GTX63745 PRAS40 (phospho Thr246) antibody [EPR6262]. Ms Synthesis GTX50267 S6 Ribosomal Protein (phospho Se 信 35) antibody. Ms. Rat Glucose Metabolism GTX61434 TSC2 (phospho Se 的 39) antibody [EP1062Y]. Ms. Rat GTX78927 TSC2 (phospho Ser1254) antibody GTX62919 TSC2 (phospho Thr1462) antibody [EPR1060(2)]. Ms GTX76675 AS 160 (phospho Th 的 42) antibody. Ms. Rb. Rat GTX50095 GSK3a (phospho Ser21) antibody. Ms. Rat GTX29765 GSK3a (phospho Ser21) antibody Rabbit GTX50090 GSK3ß (phospho Se 的 ) antibody. Ms. Rat GTX86837 GSK3ß (phospho Se 的 ) antibody. Ms. Rat Cross-Talk GTX50228 ASK1 (phospho Ser83) antibody between GTX50190 IKKa (phospho Thr23) antibody. Ms. Rat Signaling GTX78955 Raf1 (phospho Ser259) antibody. Ms. Rat Pathways GTX50227 SEK1 /MKK4 (phospho Ser80) antibody. Ms. Rat C 叭 skeletal GTX50244 Ezrin (phospho Thr567) antibody. Ms. Rat Organization GTX50245 Rac1 (phospho Ser71) antibody. Ms. Rat Other GTX50200 Chk 1 (phospho Ser280) antibody GTX50212 enos (phospho Ser1177) antibody. Ms. Rat GTX42866 enos (phospho Ser1177) antibody [BDI250] Ms mab GTX61764 PTP1 B (phospho Ser50) antibody [EP1838Y] f:.rm :".. ICC/IF, IHC, ICC/IF, IHC, ICC/IF, IHC, ELl SA, IHC, ICC/IF, IHC, ICC/IF, IHC, ELl SA, IHC-P, IP, IHC, IHC-P ELl SA, IHC-P, ELl SA, IHC, ICC/IF, IHC, ICC/IF, ICC/IF, IHC-P, IHC-P IHC, ICC/IF, IHC, IHC, IP, ICC/IF, ICC/IF, ELl SA, IHC, ICC/IF, IHC, IHC-M, ICC/IF, IHC, ICC/IF, IHC, ELl SA, IHC, IP, IHC, IHC, IHC, ICC/IF, IHC, ICC/IF. IHC-P ELl SA,

5 mtor complex & regulator mtor & GßL Complex 1 components Complex 2 components Regulators 1ilrAlH1l. GTX GTX50541 GTX22732 GTX50258 GTX79009 GTX GTX82202 GTX82789 GTX89552 GTX GTX GTX45033 GTX48547 GTX25454 GTX61370 GTX89366 GTX81899 GTX61434 GTX62919 GTX GTX GTX87391 GTX63745 聞單世祖 EE mtor (phospho Ser2448) antibody mtor (phospho Ser2448) antibody GßL antibody GßL antibody Rictor antibody [7B3] Rictor antibody OEPTOR antibody Protor antibody Protor antibody SI N 1 antibody Raptor antibody TSC1 antibody [EP318Y] TSC1 antibody TSC2 antibody TSC2 (phospho Ser939) antibody [EP1062Y] TSC2 (phospho Thr1462) antibody [EPR 1060(2)] Rheb antibody PRAS40 antibody PRAS40 antibody PRAS40 (phospho Thr246) antibody [EPR6262] l:lfl:!æ.1if: Ch pab Ms mab GtpAb GtpAb -r.. Ms. Rat. Ms. Rat. Rat. Ms. Rat. Ms. Rat, Ms, Mk, Ms, Oog, Ms, Rat, Ms, Oog, Rat, Ms, Rat, Ms, Ms, Ms, Rat, Ms I~ JiJi -;IIU IHC-P, ICC/ 悴, IHC, ICC/IF, IP, ICC/ 悴, IHC, IHC, ELl SA, ICC/IF, IHC ELl SA, IHC IHC-P, ELl SA, ELl SA, IHC, ICC/IF, ICC/IF, IHC-M, IHC-P, IHC-P, ELl SA, IHC, IP, 250 一 130 一一 ;;- A B C 130 一 一 34 一 一 一 區司 - 34 一 26 一 10 一 一 (GTX I01557): Protor antibody (GTXI24197): Rheb antibody (GTX I08597): PRAS40 antibody (GTXI18391): analysis of 293T whole cell Iysate. analysis of (A) Jurkat, (B) Raji and (C) K562 cell Iysates analysis of A431 whole celllysate analysis of (A) 293T and (B) HeLa cell Iysates Antibody sampler kits for PI3K.Akt-mTOR pathway - Akt-mTOR pathway sampler kit mtor inhibitor sampler kit Akt1+2+3, Akt1 (phosphor Ser473), PTEN, PTEN (phospho Thr366/Ser370), PI3K p110 α, POK1 (phospho Ser241) Akt1+2+3, Akt1 (phosphor Ser473), mtor, mtor (phospho Ser2448) LKB1, AMPKβ1, AMPKβ1 (phospho Se 川 81), PTEN, PTEN (phospho Thr366/Ser370) 丸 L 會 Ggnil- 在 Tel : Fax: Address: 6F-2, No.89, Dongmei Rd., East Dist., Hsinchu City 300, Taiwan (R.O.C.) info@genetex.com USA 大代 Toll-free : GeneTex( ) Fax : Address : 2456 Alton Parkway, Irvine, CA info@genetex.com

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