Molecular Mechanisms of Intestinal Lipid Transport and Metabolism. July 6-11, 2014 Base Village Conference Center Snowmass, CO

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Molecular Mechanisms of Intestinal Lipid Transport and Metabolism July 6-11, 2014 Base Village Conference Center Snowmass, CO Co-Organizers: Dennis Black, MD (Chair) University of Tennessee Health

1 Molecular Mechanisms of Intestinal Lipid Transport and Metabolism July 6-11, 2014 Base Village Conference Center Snowmass, CO Co-Organizers: Dennis Black, MD (Chair) University of Tennessee Health Science Center Memphis, TN Judith Storch, PhD Rutgers University New Brunswick, NJ Patrick Tso, PhD University of Cincinnati Cincinnati, OH Charles Mansbach, II, MD University of Tennessee Health Science Center Memphis, TN Sunday, July 6, :00PM 9:00PM 6:00PM 7:00 PM 7:00PM 8:30 PM 8:45PM 10:00PM Conference Registration FASEB Opening Reception Keynote Speaker: Lawrence Chan, MD Betty Rutherford Chair in Diabetes Research Director, Diabetes Research Center Chief, Division of Diabetes, Endocrinology and Metabolism

2 Professor of Medicine, Molecular & Cellular Biology Biochemistry & Molecular Biology, and Molecular & Human Genetics Baylor College of Medicine, Houston, TX Title: Lipid Droplets: From a Leap of Faith to a LEAP Forward Monday, July 7, 2014 Session 1: 9:00AM 9:15AM 9:15AM - 9:45AM 9:45AM 10:15AM 10:15AM 10:30 AM 10:30AM 11:00AM 11:00AM 11:30AM 11:30AM 12:00PM 12:00PM 12:15PM 12:15PM 1:15PM Physiologic Impact of Fat Absorption on Incretin and Insulin Secretion Session Chair: Patrick Tso, PhD, University of Cincinnati Welcome from FASEB Khosrow Adeli, PhD, Hospital for Sick Children, Toronto CNS Regulation of Intestinal Lipoprotein Production: Evidence that Glucagon-Like Peptide-1 Reduces Intestinal Lipid Availability and Lipoprotein Production Via a Gut-Brain Axis Gary Lewis, MD, University of Toronto Regulation of Intestinal Lipid Particle Production in Humans Group Photo & FASEB Sponsored Coffee Patrick Tso, PhD, University of Cincinnati Effect of High-Fat Diet on GI Incretins Alison Kohan, PhD, University of Cincinnati Role of Dietary Lipid in Incretin and Insulin Secretion 4:00PM 6:00PM Poster Session 1 Session 2: 7:00PM - 7:30PM Neonatal Lipid Absorption Session Chair: Dennis Black, MD, University of Tennessee Health Science Center Mark Lowe, MD, PhD, University of Pittsburgh Pancreatic Lipases In the Newborn

3 7:30PM 8:00PM 8:00PM 8:15PM 8:15PM 8:30PM 8:30PM 8:45PM 8:45PM 9:15PM 9:15PM 9:45PM Kelly Tappenden, PhD, RD, University of Illinois Short-Chain Fatty Acids and Intestinal Adaptation In the Neonate TBN Emma Tillman, PharmD, PhD, University of Tennessee Health Science Center Use of Enteral Fish Oil in Intestinal Failure in Infants Tuesday, July 8, 2014 Session 3 9:00AM - 9:30AM 9:30AM 10:00AM 10:00AM 10:15AM 10:15AM 10:45AM 10:45AM 11:15AM 11:15AM 12:00PM 12:00PM 12:15PM 12:15PM 1:15PM 1:15PM 2:15PM Impact of the Microbiome on Intestinal Lipid Absorption Session Chair: Eugene Chang, MD, University of Chicago Balfour Sartor, MD, UNC Chapel Hill The Intestinal Microbiome, Inflammation and Gut function Eugene Chang, MD, University of Chicago The Impact of the Gut Microbiota on Host Lipid Metabolism FASEB Sponsored Coffee TBN Gut Microbiome, Obesity and Metabolic Dysfunction John Rawls, PhD, Duke University Medical Center Microbial Regulation of Fatty Acid Absorption in Zebrafish Meet the Expert Session 4:00PM 6:00PM Poster Session 2 Session 4: Intestinal Lipid Transporters Session Chair: Judith Storch, PhD, Rutgers University

4 7:00PM - 7:30PM 7:30PM 8:00PM 8:00PM 8:15PM 8:15PM 8:30PM 8:30PM 8:45PM 8:45PM 9:15PM 9:15PM 9:45PM Nada Abumrad, PhD, Washington University School of Medicine Enteroendocrine Cell CD36 Mediates Intestinal Peptide Release Judith Storch, PhD, Rutgers University Enterocyte Fatty Acid Uptake and Trafficking David Hui, PhD, University of Cincinnati Mouse Models for the Study of Intestinal Lipid Transporters Paul Black, PhD, University of Nebraska Molecular Dissection of the Mechanistic Basis of Fatty Acid Transport Protein 2 Function Using Small Molecule Inhibitors Wednesday, July 9, 2014 Session 5 9:00AM - 9:30AM 9:30AM 10:00AM 10:00AM 10:15AM 10:15AM 10:45AM 10:45AM 11:15AM 11:15AM 12:00PM 12:00PM 12:15PM 12:15PM 1:15PM Role of Cytoplasmic Lipid Droplets in Intestinal Lipid Absorption Session Chair: Kimberly Buhman, PhD, Purdue University Kimberly Buhman, PhD, Purdue University DGAT 1 and 2 in Intestinal Triacylglycerol Storage Versus Secretion Christine Coméra, PhD, INRA, Toulouse, France Characterization of Cytoplasmic Lipid Droplets and Their Trafficking in Mouse Intestine and Caco-2 Cells FASEB Sponsored Coffee Ho Yi Mak, PhD, Stowers Institute for Medical Research Lipid Droplet Formation in Intestine in C. elegans Steven Farber, PhD, Carnegie Institute Intestinal Lipid Absorption, Transport and Droplet Formation in Live Zebrafish Larvae

5 4:00PM 6:00PM Poster Session 3 Session 6: 7:00PM - 7:25PM 7:25PM 7:50PM 7:50PM 8:05PM 8:05PM 8:20PM 8:20PM 8:35PM 8:35PM 9:00PM 9:00PM 9:25PM 9:25PM 9:35PM Thursday, July 10, 2014 Session 7 9:00AM - 9:30AM 9:30AM 10:00AM 10:00AM 10:15AM 10:15AM 10:45AM 10:45AM 11:15AM 11:15AM 12:00PM Intestinal Bile Acid Metabolism Session Chair: Benjamin Shneider, MD, University of Pittsburgh Alan Hofmann, MD, University of California, San Diego Research in Bile Acid Metabolism: A Historical Perspective Paul Dawson, PhD, Emory University School of Medicine Intestinal Bile Acid Transporter Biology Benjamin Shneider, MD, University of Pittsburgh Regulation of the Ileal Bile Acid Transporter Melissa Halpern, PhD, University of Arizona Bile Acid Transporters in Necrotizing Enterocolitis Benjamin Shneider, MD, University of Pittsburgh Bile Acid Transport Inhibitors-Evolving Clinical Trials Intestinal Chylomicron Assembly Session Chair: Charles Mansbach, II, MD, University of Tennessee Health Science Center Scot Stone, PhD, University of Saskatchewan DGAT2 and MGAT2 Interact to Promote Triacylglycerol Synthesis Charles Mansbach, II, MD, University of Tennessee Health Science Center Control of Chylomicron Export By the Intestine FASEB Sponsored Coffee Mahmood Hussain, PhD, SUNY Downstate Medical Center Molecular Mechanisms and Regulation of Intestinal Lipid Absorption James McKnight, PhD, Boston University Early Events in Apolipoprotein B-Containing Lipoprotein Assembly

6 12:00PM 12:15PM 12:15PM 12:45PM 12:45PM 1:45PM Business Meeting 1:00PM 6:00PM Organized Group Activity 4:00PM 6:00PM Poster Session 4 Session 8: 7:00PM - 7:30PM 7:30PM 8:00PM 8:00PM 8:15PM 8:15PM 8:30PM 8:30PM 8:45PM 8:45PM 9:15PM 9:15PM 9:45PM Friday, July 11, :30AM 8:30AM Session 9 8:30AM 10:30AM Roles of Apo B and Apo A-IV in Chylomicron Formation Session Chair: Mahmood Hussain, PhD, SUNY Downstate Medical Center Gregory Shelness, PhD, Wake Forest University Apolipoprotein A-IV Expression in Mouse Liver Enhances Triglyceride Secretion and Reduces Hepatic Lipid Content by Promoting VLDL Particle Expansion Richard Weinberg, MD, Wake Forest University Modulation of Lipid Transport by Apolipoprotein A-IV Dennis Black, MD, University of Tennessee Health Science Center Regulation of Chylomicron Size and Secretion by Apo A-IV Xiaoyue Pan, PhD, SUNY Downstate Medical Center Circadian Regulation of Dietary Lipid Absorption Meet the Experts Session Chair: Patrick Tso, PhD, University of Cincinnati Panelists: Dennis Black, MD; Eugene Chang, MD; Judith Storch, PhD; Kimberly Buhman, PhD; Benjamin Shneider, MD ;Charles Mansbach, II, MD; Mahmood Hussain, PhD 10:30AM 10:45AM 10:45AM Closing Comments Departures

7 Boxed es Available END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD

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