THE IMPORTANCE OF KNOWING YOUR OMEGA-3 INDEX: RECENT FINDINGS AND IMPLICATIONS FOR PUBLIC HEALTH PEOPLE MATTER PLANET MATTERS PROFIT MATTERS

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1 THE IMPORTANCE OF KNOWING YOUR OMEGA-3 INDEX: RECENT FINDINGS AND IMPLICATIONS FOR PUBLIC HEALTH PEOPLE MATTER PLANET MATTERS PROFIT MATTERS Andreas Berg Storsve PhD, Director R&D

2 9.7 Billion people 2x Number of people >60 years of age 42% 22.2 Obesity rate in US population USD trillion healthcare cost lifestyle diseases UN DESA report: World Population Prospects: The 2015 Revision The Global Footprint Network: World Footprint 2015 SINTEF: Marine ressurser et kjempepotensial for Norge 14.april 2015

3 The Ocean is part of the solution 70% of the planet is covered by oceans 2% of food consumption from oceans 0.5% FDA approved pharmaceuticals from oceans United Nations World Ocean Assessment UiT: E.Elvevoll, Food from the Oceans nutritious and safe food, April 16

4 OMEGA-3 PREVENTS LIFESTYLE DISEASES (NCD S) 9000 PUBLISHED PAPERS ON PREVENTIVE EFFECTS Spent Saved* *Frost & Sullivan, 2016

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6 The Omega-3 Index Harris WS and von Schacky C. Prev Med 2004;39:

7 Meta-Analysis: Omega-3 Index as a Predictor of Risk for Fatal Coronary Heart Disease (10 studies worldwide - over 27,000 subjects) Risk for fatal CHD was 35% lower in persons with an Omega-3 Index of 8% compared with those with an Index of 4% Omega-3 Index Harris WS, et al. Atherosclerosis 2017;262:51-54

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9 Krill oil contains Phospholipid-bound DHA and EPA and is a good source of Choline Structural form Triglyceride (fish oils) Glycerol Phospholipids (krill oil) Choline Phosphate Glycerol Fatty acids Fatty acids Characteristics Non-polar Hydrophobic does NOT mix with water Polar Hydrophilic - mixes with water Function Energy storage Fat cell Main structural component in all cell membranes Membrane

10 Change in Omega-3 Index (% points) Omega-3 Index (%) Human studies indicate a significantly higher increase in Omega-3 Index with phospholipids (krill oil) than with triglycerides (fish oil) Study overview Single center, doubleblinded, placebo-controlled, randomized two-way crossover study Subjects 24 Healthy male and female subjects (12m, 12f) Treatment 4-weeks of daily intake 8-weeks wash-out between treatments 3g krill oil or fish oil, but EPA+DHA was 17% higher in krill oil than in fish oil 3g corn oil as placebo Absolute values (Mean±SD) Increased uptake in red blood cells Krill oil Fish oil Corn oil Baseline End-point Mean change, corrected for EPA+DHA dose p< Ramprasath et al., Lipids Health Dis. 2013, 12;178 10

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12 Normal Alzheimers 12

13 Measuring the human brain 13

14 Longitudinal cortical decline with advancing age Storsve et al. (2014), J Neurosci 14

15 The Temporal Cortex is especially vulnerable to ageing. However, there is huge individual variability in rate of decline. Temporal cortex Frontal cortex Storsve et al. (2014), J Neurosci 15

16 Walhovd, Storsve et al. (2014), Neurobiol Aging 16

17 Hippocampus volume is related to Omega-3 Index Pottala et al., 2014, Neuron 17

18 Higher brain incorporation of PUFAs1 in phospholipid than triglyceride form DHA uptake in rat brain 1 DHA uptake in piglet brain 2 Study on DHA incorporation into rat brain after administration of radiolabelled DHA in the form of PL or TG [kbq/g tissue] Incorporation of labeled DHA x 2,2 2,6 Study on DHA incorporation into piglet brain after administration of radiolabelled DHA in the form of PL or TG x 1,9 [kbq/g tissue] Incorporation of labeled DHA 0,40 Single oral dose 1,2 Single oral dose 0,21 10 weeks of age 16 days of age TG PL TG PL 1. Graf B.A., et al Prostaglandins Leukot Essent Fatty Acids, 83: Liu L., et al J Lipid Res, E-pub Jan 27 18

19 The Rangers trial will investigate effects of high dose Superba Boost TM on resiliency (resistance to stress) and performance improve overall and individual performance during IBOLC? reduce rate of failure rate during Ranger? reduce incidence of adverse emotional and psychological events during IBOLIC, Ranger and 1 month post -Ranger? improve neuropsychological functioning under stressed conditions? 19

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21 Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, affecting 75m Americans 21

22 Untreated NAFLD can progress into NASH, and subsequently permanent liver damage, cirrhosis and liver cancer Development of liver disease in metabolic syndrome. Choline deficiency a central factor. Steatosis Steatohepatitis Reversible through lifestyle changes Superba may maintain/restore healthy liver Disease, permanent damage and progression Superba may reduce inflammation and severity 22

23 Dysregulated cholesterol homeostasis is a hallmark of NAFLD, and can be restored by krill oil supplementation in NHP Total cholesterol LDL HDL Data presented are control-adjusted mean values Hals et al., Lipids Health Dis. 2017, 16; 11

24 Superba Boost TM qualifies for three EU-authorized Choline claims. Continuing work on NAFLD with TNO Netherlands. Choline contributes to the maintenance of normal liver function Choline contributes to normal lipid metabolism Choline contributes to normal homocysteine metabolism

25 Omega-3 Index Omega-3 Index following administration of Krill oil (PL98) to NHPs 25% Control no. 1 Control no. 2 Control no. 3 Treated no. 1 Treated no. 2 Treated no. 3 20% 15% 10% 5% 0% 50 mg/kg/d 150 mg/kg/d 450 mg/kg/d Wash-out Time (weeks) Hals et al., Lipids Health Dis. 2017, 16; 16

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27 Get your Omega-3 Index measured at our stand! Hall 11.1, StandD62