3 Normal-Phase Columns. Reversed-Phase C18 Columns (ODS) Reversed-Phase Columns (Other than ODS) Columns for HTS and LC/MS Analysis.

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1 We are pleased to present the 11th YMC General Catalog. Since its formation in 1980, YMC Co., Ltd. has been working in the rapidly changing field of chemistry. Over this time, the rate of discovery of new materials and technologies for improving the quality of life have been occurring at rates never dreamed of by past generations. Additionally, chemistry disciplines are becoming increasingly cross-linked with each other as well as with related technologies, and these discoveries generate an even greater impact on the expansion of all chemical and biological fields. YMC Co., Ltd. believes that progress in chemistry is infinite and has focused its resources in the field of High Performance Liquid Chromatography, a key technology that contributes to the discovery, analysis, and purification of important chemical substances. Substances that are discovered, analyzed, and/or purified using YMC products frequently contribute to the improved health and well being of human and animal populations. For example, YMC is extremely proud of the important contribution that our company makes in the area of diabetes care. Compounds used in the treatment of diabetes are often analyzed and/or purified using YMC products developed and manufactured by our company. YMC s intellectual assets and the know-how cultivated by many years of experience with High Performance Liquid Chromatography have been combined with complementing technology platforms so that we can continue our challenge of pushing limits in precision, detection, discovery, and production. The following pages in this catalogue represent the fruits of our company s effort towards helping YMC fulfill its mission of helping our customers succeed in sustaining and improving the quality of life for the present and future generations. Ryuji Yamamura CEO. 第 0 章 _ indd :30:01 AM

2 11th C O N T E N T S Introduction 1 Contents 2,3 What s New 4,5 Please read this section before ordering 6 Purchasing products 7 YMC columns 8,9 Column selection guide 10,11 1 Reversed-Phase C18 Columns (ODS) Types and characteristics of C18 packing materials 14 Guides for selecting C18 packing materials YMC-UltraHT series YMC-UltraHT series 24,25 YMC-UltraHT Pro C18 26 YMC-UltraHT 27 Pro series Features of Pro series ODS columns YMC-Pack Pro C18 YMC-Pack Pro C18 RS YMC-Pack ODS series YMC-Pack ODS-A 44,45 YMC-Pack ODS-AM 46,47 YMC-Pack ODS-AQ 48,49 YMC-Pack ODS-AL 50,51 J sphere ODS series ODS-H80 M80 L80 52,53 YMC-Pack PolymerC18 54,55 2 Reversed-Phase Columns (Other than ODS) Types and characteristics of reversedphase columns (other than ODS) 58,59 YMC-Pack Pro C8 C YMC-Pack C8 64,65 YMC-Pack C4 66,67 YMC-Pack TMS 68,69 YMC-Pack Ph 70,71 YMC-Pack CN 72,73 YMC-Pack PROTEIN-RP 74,75 YMCbasic 76 YMC Carotenoid 77 3 Normal-Phase Columns Types and characteristics of normal-phase columns 80,81 YMC-Pack SIL SIL-06 82,83 YMC-Pack CN 84,85 YMC-Pack Diol-NP 86,87 YMC-Pack Polyamine Ⅱ 88,89 YMC-Pack NH2 90 YMC-Pack PA-G 90 YMC-Pack PVA-Sil 91 YMC columns for SFC separation 92 4 Columns for HTS and LC/MS Analysis Semi-micro columns for LC/MS 9496 YMC-UltraHT series 97 YMC CombiChrom 98,99 第 0 章 _ indd :30:02 AM

3 5 Columns and bulk packings for BIO-MACRO Molecular Separations Types and characteristics of columns and bulk packing for BIO-MACRO molecular separations YMC-BioPro Ion Exchange columns 106 YMC-BioPro QA-F/YMC-BioPro SP-F 107 YMC-BioPro QA/YMC-BioPro SP 108,109 YMC-BioPro Ion Exchange media 110,111 YMC-Pack Diol 112,113 Reversed-phase columns for bio molecules YMC-Pack PROTEIN-RP 122,123 YMC-Pack Diol-NP 124 YMC-Pack Polyamine Ⅱ Optical Isomer Separation Columns YMC CHIRAL CD BR series 128,129 YMC CHIRAL NEA 130,131 YMC CHIRAL PREP CD ST/PM 132,133 7 Preparative Columns Overview of optimization methods for isolation/purification 136,137 YMC-Actus series YMC-Pack Pro C18 142,143 YMC-Pack R&D series 144 YMC-Pack preparative columns ODS series C8 C4 148,149 TMS Ph 150 CN 151 SIL SIL Polyamine Ⅱ NH2 153 Diol 153 YMC-DispoPack Packing Materials YMC-Exphere C18 156,157 YMC*GEL HG series 156,157 Types and characteristics of packing materials 158,159 Spherical packing materials for preparative isolation Irregular packing materials for preparative isolation 164 Sample Pretreatment, 9 Accessories Sample pretreatment 166 Column protection 167,168 Tubing parts Empty columns and other parts Pressure resistant empty glass columns 177,178 Preparative Systems 10 Microreactor Preparative Systems Preparative HPLC systems Dynamic axial compression system 183 Self-packing system for preparative column 184,185 Bioprocess chromatography systems Microreactor Flow-micro Reaction systems Reactors (Micro mixers) 196 Pumps 196 Accessories, Parts Contract Services Overview of contract services 200,201 YMC Co., Ltd. s synthesis and purification technology 202 The state-of-the-art facilities and large scale factory Sumitomo Chemical Co., Ltd. SUMICHIRAL Handling Products Information Column handling 212 Mobile phases for ODS columns 213 HPLC column performance 214 Inspection reports 215 FAQ 216,217 Troubleshooting 218,219 Basic Data Index Index Reversed-Phase C18 Columns(ODS) 2Reversed-Phase Columns (Other than ODS) 3Normal-Phase Columns 4Columns for HTS and LC/MS Analysis 5Columns and bulk packing for BIO-MACRO Molecular Separations 6Optical Isomer Separation Columns 7Preparative Columns 8Packing Materials 9Sample Pretreatment, Accessories 10 Preparative Systems Microreactor 11 Contract Services 12 Handling Products 13 Information 14 Index 第 0 章 _ indd :30:03 AM

4 What s New Versatile hybrid silica based HPLC columns Hybrid silica base Great chemical durability Lower back pressure Excellent resolution YMC-BioPro series YMC-BioPro QA-F / SP-F columns Ion exchange chromatography for peptides and proteins Hydrophilic polymer beads Non-porous type for ultra fast analysis Excellent resolution 106, 107 YMC-BioPro QA / SP columns Ion exchange chromatography for peptides and proteins Hydrophilic polymer beads Porous type for analysis with high recovery Excellent resolution 108, 109 YMC-BioPro QA / SP bulk media Ion exchange chromatography for peptides and proteins Hydrophilic polymer beads High recovery for biomolecules Two particle sizes (30, 75 µm) available 110, 111 第 0 章 _ indd :30:03 AM

5 YMC-Actus series Excellent efficiency and durability preparative HPLC column Improved durability by applying axial compression technology Prepacked column for milligram scale preparative Excellent separation YMC-DispoPack Disposable columns for preparative chromatography Disposable type prepacked column for preparative Various preparative systems are connectable by using Luer-lock connections 154 YMC-Exphere C18, YMC*GEL HG series High mechanical stability packing materials with high chemical stability for preparative separation High density and high strength silica gel Narrow particle distribution and pore size Excellent separation 156, 157 Flow-micro reaction systems Systems are complete to start flow-micro reaction. Versatile flow chemistry systems covering from laboratory use to production scale. Customized system are available to fit user s reactions Selectable system depending on price and reactions user s need 第 0 章 _ indd :30:03 AM

6 Checking a catalog item Ordering informationcheck your desired product in the ordering information section on each page. Analytical columns Particle size (µm) Pore size (Å) Column size inner diameter length(mm) Product number S AS12S03-H501WT AS12S WT AS12S WT AS12S03-H5P5WT AS12S03-05P5WT Packing material type Pore size Column size Product number S: Spherical packing material I: Irregular packing material Inner diameter length is expressed in mm. Checking the product label Check these items on the label of your product before re-ordering. Product name Column size Particle size, pore size Product No. Serial No. 第 0 章 _ indd :30:06 AM

7 YMC Co., Ltd. products are available all over the world. YMC America, Inc. in North and South America, YMC Europe GmbH in Europe, the Middle East and Africa, YMC India Pvt. Ltd. in India, and YMC Co., Ltd. in South East Asia and Australia conduct sales activities as local business bases. Our products are available through local distributors. For distributors all over the world, visit our web site: URL ö URLhttp://ymcamerica.com URLhttp:// URLhttp:// 第 0 章 _ indd :30:07 AM

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10 Pharmaceutical products Agricultural chemicals Antibiotics Antimicrobial agents Metabolites Steroids Food additives Natural products Others Neutral compounds Acidic compounds Pro series ODS Pro series C8, C4 YMC-Pack ODS series YMC-Pack C8, C4 J'sphere ODS series YMC-Pack Ph YMC-Pack CN YMC-Pack TMS YMC-Pack PolymerC18 High performance ODS column processed with advanced endcapping technology High performance reversed-phase column processed with advanced endcapping technology Conventional ODS column Useful for cases in which retention is too strong using ODS Three kinds of ODS with different carbon contents Reversed-phase column utilizing - interaction Can be used in both normal-phase and reversed-phase modes Reversed-phase column with the lowest hydrophobicity Polymer type reversed-phase column without effect from silanol P.28~43 P.60~63 P.44~51 P.64~67 P.52,53 P.70,71 P.72,73 P.68,69 P.54,55 Basic compounds Pro series ODS Pro series C8, C4 Provides good peak shapes for basic compounds Useful for cases where retention is too strong using ODS P.28~43 P.60~63 Hydrophilic compounds YMC-Pack ODS-AQ YMC-Pack CN YMC-Pack TMS Stronger retention of hydrophilic compounds than conventional ODS Can be used in both normal-phase and reversed-phase modes Reversed-phase column with the lowest hydrophobicity P.48,49 P.72,73 P.68,69 Normalphase YMC-Pack SIL, SIL-06 YMC-Pack CN YMC-Pack Diol-NP YMC-Pack Polyamine YMC-Pack NH2 Standard normal-phase column Can be equilibrated faster than bare silica gel Normal-phase column providing separation characteristics different from bare silica gel Amino column with improved durability Normal-phase column utilizing the polarity of amino groups P.82,83 P.84,85 P.86,87 P.88,89 P.90 Vitamins Water-soluble vitamins YMC-Pack Pro C18 Provides good peak shapes due to advanced endcapping technology P.32~35 Fat-soluble vitamins YMC-Pack Pro C18 YMC-Pack ODS-A YMC-Pack ODS-AM Provides good peak shapes due to advanced endcapping technology Conventional ODS column ODS column with outstanding lot-to-lot reproducibility P.32~35 P.44,45 P.46,47 Normalphase Water-soluble vitamins YMC-Pack Polyamine YMC-Pack NH2 Amino column with improved durability Normal-phase column utilizing the polarity of amino groups P.88,89 P.90 Fat-soluble vitamins YMC-Pack SIL,SIL-06 YMC-Pack Polyamine Standard normal-phase column Amino column with improved durability P.82,83 P.88,89 Sugars Size exclusion YMC-Pack Diol Useful for molecular weight determination of sugars P.112~113 Oligosaccharides YMC-Pack ODS-AQ Stronger retention of hydrophilic compounds than conventional ODS P.48,49 Normalphase Monosaccharides Oligosaccharides YMC-Pack Polyamine YMC-Pack NH2 YMC-Pack PA-G Amino column with improved durability Normal-phase column utilizing the polarity of amino groups Column chemically bonded with polyamine P.88,89 P.90 P 第 0 章 _ indd :30:12 AM

11 Organic acids Fatty acids Organic acids YMC-Pack ODS-AQ Stronger retention of hydrophilic compounds than conventional ODS P.48,49 Normalphase YMC-Pack SIL,SIL-06 Standard normal-phase column P.82,83 Amino acids Free amino acids Labeled amino acids YMC-Pack ODS-AM YMC-Pack Pro C18 ODS column with outstanding lot-to-lot reproducibility Provides good peak shapes due to advanced endcapping technology P.46,47 P.32~35 Proteins Peptides Ion exchange YMC-BioPro Ion exchange column Suitable for peptide and protein separation P.106~109 Size exclusion YMC-Pack Diol Useful for analysis of proteins or peptides P.112,113 Molecular weight 10,000 or less Proseries ODS YMC-Pack ODSseries YMC-Pack PROTEIN-RP YMCbasic Provides good peak shapes due to advanced endcapping technology Conventional ODS column Specialized column with excellent acid resistance for separation of proteins or peptides Useful for separation of peptide due to minimized secondary interaction P.28~43 P.44~51 P.74,75 P.76 Molecular weight 10,000 or more Wide-Pore Columns YMC-Pack PROTEIN-RP Column with wide pore size useful for analysis of macromolecules Specialized column with excellent acid resistance for separation of proteins or peptides P.118~121 P.74,75 Nucleic acids Ion exchange YMC-BioPro Ion exchange column Suitable for oligonucleotide and nucleic acid separation P.106~109 Size exclusion YMC-Pack Diol Useful for separation of oligonucleotides and nucleic acids P.112,113 Nucleic acid bases Nucleosides Nucleotides YMC-Pack ODS-AQ Stronger retention of hydrophilic compounds than conventional ODS P.48,49 Oligonucleotides YMC-Pack ODS-AQ Stronger retention of hydrophilic compounds than conventional ODS YMC-Pack ODS-A Wide-PoreWide-Pore ODS column useful for separation of macromolecules P.48,49 P.118 Structural isomers YMC-Pack Pro C18 RS J'sphere ODS-H80 YMC Carotenoid Highly endcapped polymeric type ODS column with excellent ability to recognize planar structure Polymeric type ODS column with excellent ability to recognize planar structure Useful for carotenoids separation P.40~43 P.52,53 P.77 Normalphase YMC-Pack SIL,SIL-06 Standard normal-phase column P.82,83 Optical isomers YMC CHIRAL CD-BR series YMC CHIRAL NEA Cyclodextrin type optical isomer separation column Synthesized macromolecule-type optical isomer separation column P.128,129 P.106,107 Normalphase YMC CHIRAL NEA Normal-phase column for separation of optical isomers P.130, 第 0 章 _ indd :30:12 AM

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