Formulation Guidelines for Synastol TC

Transcription

1 Formulation Guidelines for Synastol TC Synastol TC is a standardized fruit extract of Terminalia Chebula with high content of hydrolysable tannins, typically 50-60%. Synastol TC is 100% natural and it can be easily formulated into stable emulsions, hydrolipid dispersions and serums. Stability testing carried out with 0.5% Synastol TC nonionic lotion at 45 0 C showed minimal color shift after three months. Synastol TC is highly water soluble; therefore it should be dissolved in water prior to adding to the formulation.. Synastol TC should be used at a level of % (w/w) of finished formulation. Synastol TC should be pre-solubilized in water and added to the emulsion below 45 C with continuous mixing. For preparation of cold process serums we recommend natural gelling agents, such as Cellulose derivatives, Xanthan Gum & Carrageenan Gum. The finished product must be acidic, preferably having ph below 6. A ph below 5.5 is recommended when potassium sorbate or sodium benzoate is used as preservatives. Synastol TC is highly recommended for skincare, sun care, and body care and anti-aging lotions for improving conditions condition of skin and preventing future skin damage. Should you need any additional information on this subject, please contact Dr. Ratan Chaudhuri, either by calling at or ing at ratan@sythonltd.com January,

2 Anti-Aging Lotion with 0.5% Synastol TC Formulation RC#01-26 INCI name Trade Name/Supplier Glycerin Glycerin 99%/Ruger 3.00 Butylene Glycol Butylene Glycol 2.00 Acrylates/C10-30 Alkyl Acrylate Copolymer Carbopol Ultrez 21/Lubrizol 0.25 Caprylic/Capric Triglycerides Myritol 318/BASF 5.00 Butyrospermum Parkii (Shea Butter) Shebu Refined /Rita 2.00 Glyceryl Stearate, PEG-100 Stearate Arlacel 165/Croda 2.50 Cetearyl Alcohol,Ceteareth 20 Promulgen D/Lubrizol 1.50 Dimethicone DC, 200/100CST/Dow Corning 2.00 Isosorbide Dicaprylate Synovea DOI/Sytheon 2.00 Behenyl Alcohol Lanette 22/BASF 0.75 Triethanolamine 99% Trolamine 99 (to ph 5.5) 0.20 Polyacrylamide, C13-14 Isoparaffin, Laureth-4 Sepigel 305/Seppic 0.75 Water Water 2.00 Terminalia Chebula Extract Synastol TC/Sytheon 0.50 Phenoxyethanol, Ethylhexyglycerine Euxyl PE 9010/Schuelke 1.00 Procedure: Combine A-1; disperse A2 in A1 while stirring and heat A to 75 0.C Combine phase B ingredients then heat to 40 0 C and slowly add pre-mixed phase E; stir gently until mixture is homogeneous and then add phase F. Viscosity: 35,000-50,000 cps (Brookfield RVT, spindle C, Helipath) at 25 0 C The information given and the recommendations made herein are based on our research and are believed to be accurate but no guarantee of their accuracy is made. This information is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use of the formulation, procedure or products suggested herein. Neither is any permission or recommendation to practice any invention covered by patent either expressed or implied 2

3 Even Toning Skin Lotion- 0.5% Synovea HR & 0.5% Synastol TC Formulation RC#01-25 INCI name Trade Name/Supplier % w/w Glycerin Glycerin 99%/Ruger 3.00 Acrylates/C10-30 Alkyl Acrylate Copolymer Carbopol Ultrez 21/Lubrizol 0.25 Caprylic/Capric Triglycerides Myritol 318/BASF 5.00 Butyrospermum Parkii (Shea Butter) Shebu Refined /Rita 2.00 Glyceryl Stearate, PEG-100 Stearate Arlacel 165/Croda 2.00 Potassium Cetyl Phosphate Amphisol K/DSM 1.00 Dimethicone DC, 200/100CST/Dow Corning 2.00 Isosorbide Dicaprylate Synovea DOI/Sytheon 2.00 Bisabolol Natural Alpha Bisabolol 0.15 Cetyl Alcohol Crodacol-C70/Croda 1.00 Triethanolamine 99% Trolamine 99 (to ph 5.5) 0.20 Hydroxylethyl acrylate/sodium Acryloyldimethyl taurate Copolymer, Squalane,Polysorbate 60 Simulgel NS/Seppic 1.00 Butylene Glycol Butylene Glycol/Ruger 2.00 Hexylresorcinol Synovea HR/Sytheon 0.50 Water(demineralized) 2.00 Terminalia Chebula Extract Synastol TC/Sytheon 0.50 Phase G Phenoxyethanol, Ethylhexyglycerine Euxyl PE 9010/Schulke 1.00 Procedure: Combine A-1; disperse A2 in A1 while stirring and heat A to 75 0 C. Combine phase B ingredients then heat to 40 0 C and slowly add pre-mixed phase E and F; stir gently until mixture is homogeneous and then add phase G. Viscosity: 20,000-40,000 cps (Brookfield RVT, spindle C, Helipath) at 25 0 C The information given and the recommendations made herein are based on our research and are believed to be accurate but no guarantee of their accuracy is made. This information is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use of the formulation, procedure or products suggested herein. Neither is any permission or recommendation to practice any invention covered by patent either expressed or implied 3

4 Anti-Aging lotion with 1% Synastol TC- clinically tested Formulation RC#01-35 INCI name Trade Name/Supplier Glycerin Glycerine 99%/Ruger 2.50 Butylene Glycol Butylene Glycol 1.50 Acrylates/C10-30 Alkyl Acrylate Copolymer Carbopol Ultrez 21/Lubrizol 0.30 Ethylhexyl Palmitate Rita OP/Rita Corp 4.00 Butyrospermum Parkii (Shea Butter) Shebu Refined /Rita 1.50 Glyceryl Stearate, PEG-100 Stearate Arlacel 165/Croda 1.00 Cetearyl alcohol, Ceteareth-20 Promulgen D/Lubrizol 2.00 Dimethicone DC, 200/50CST/Dow Corning 2.00 Isosorbide Dicaprylate Synovea DOI /Sytheon 2.00 Cyclopentasiloxane, Polysilicone-11 Gransil GCM-5/Grant Industries 3.00 Cetyl Alcohol Crodacol C-70/Croda 1.00 Triethanolamine Triethanolamine 0.10 Polyacrylamide,C13-14 Isoparaffin, Laureth-7 Sepigel 305/Sepic 0.75 Water Water 2.00 Terminalia Chebula Fruit Extract Synastol TC/Sytheon 1.00 Caprylyl Glycol, Phenoxyethanol, Hexylene Glycol Lexard HPO/Inolex 1.00 Procedure: Combine A-1; disperse A2 in A1 while stirring and heat A to 75. Combine phase B ingredients then heat to 40C and slowly add pre-mixed phase E. Add phase C; stir gently until mixture is homogeneous and then add phase F. Viscosity: 30,000-50,000 cps (Brookefield RVT, spindle C, Helipath) at 25 C The information given and the recommendations made herein are based on our research and are believed to be accurate but no guarantee of their accuracy is made. This information is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use of the formulation, procedure or products suggested herein. Neither is any permission or recommendation to practice any invention covered by patent either expressed or implied. 4

5 Eye Balm with 0.5% SyNastol TC Formulation#RC INCI name Trade Name/Supplier % w/w Phase A1 Water Water(demineralized) Qs Disodium EDTA Versene Na/Dow 0.10 Glycerin Emery 916/CBASF 2.00 Butylene Glycol Butylene Glycol/Ruger 2.00 D Panthenol Panthenol/BASF 0.10 Phase A2 Xanthan Gum Keltrol CG-T/CP Kelko 0.10 Carbomer Carbopol Ultrez 10/Lubrizol 0.30 Sucrose Stearate Crodesta F160-PW/Croda 1.50 Caprylic/Capric Triglycerides Ritamollient CTG/Rita 5.00 Shea Butter Shebu Refined / Rita 2.50 Cetyl Alcohol Crodacol C-70/Croda 1.25 Cetearyl Alcohol, Ceteareth-20 Promulgen D/BASF 2.50 Glyceryl Stearate, PEG-100 Stearate Arlacel 165/Croda 1.50 Dimethicone Dow Corning 200,100 cst/dow Corning 1.00 Isosorbide Dicaprylate Synovea DOI/Sytheon 2.00 Alpha Tocopherol Vitamin E/Basf 0.20 Isononyl Isononanoate Ritamollient ININ/Rita 3.00 C10-30 Cholesterol/Lanosterols Esters Super sterol Liquid-LQ/Croda 1.00 Triethanolamine TEA 99% 0.20 Hydroxylethyl acrylate/sodium Acryloyldimethyl taurate Copolymer, Squalane,Polysorbate 60 Simulgel NS/Seppic 0.80 Water(demineralized) 2.00 Terminalia Chebula Fruit Extract Synastol TC/Sytheon 0.50 Phenoxyethanol, Ethylhexyglycerine Euxyl PE 9010/Schulke 1.00 Procedure: Combine A-1; disperse A2 one by one in A1 while stirring and heat A to 75 C. Combine ingredients of phase B and heat to 75 0 C. Add phase B to A with good mixing. Homogenize mixture at moderate speed for 3-5 min while adding phase C (adjust ph to 5.5) followed by phase D. Cool batch to 45 0 C with propeller agitation until mixture is homogeneous. Add pre-mixed phase E ingredients followed by phase F while continue mixing. The information given and the recommendations made herein are based on our research and are believed to be accurate but no guarantee of their accuracy is made. This information is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use of the formulation, procedure or products suggested herein. Neither is any permission or recommendation to practice any invention covered by patent either expressed or implied. 5