CCSS Investigator Meeting Plenary Session June 12, 2013 Memphis, TN. The Childhood Cancer Survivor Study
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1 CCSS Investigator Meeting Plenary Session June 12, 2013 Memphis, TN
2 Schedule Wednesday 2:00 3:40pm Update Reports 4:00 7:00pm Career Development Awardee and Research Presentations 7:00 8:00pm Reception Thursday 7:00 8:00am Continental Breakfast 8:00 9:30am Ancillary Intervention Studies 9:30 - noon Working Group Reports 12:00 1:00pm Working Group Breakout Sessions
3 Presentations CCSS Career Development Awardee: Dr. Sogol Mostoufi-Moab Children s Hospital of Philadelphia University of Pennsylvania Risk of Chronic Endocrine Disorders in Adult Survivors of Childhood Cancer
4 Research Presentations PRESENTER Paul Nathan (Stefan Essig) Lisa Diller (Sara Barton) Lennie Wong Yutaka Yasui Monica Gramatages Lindsay Morton TOPIC Standard Risk ALL Outcomes Infertility Treatment and Pregnancy Efficacy of COG Guidelines for Heart Failure Calculating Cumulative Total Incidence Telemore Length and Second Malignancy Update on Genome-wide Association Study of Second Neoplasms
5 Research Presentations Ancillary Intervention Studies PRESENTER Alan Geller Kevin Oeffinger Melissa Hudson Cheryl Cox TOPIC Reducing Skin Cancer Risk EMPOWER Breast Screening ECHOS Cardiac Screening
6 CCSS Career Development Award Fall 2012 Review Committee (P. Nathan Chair) 14 Applications Received High quality and diverse topics Awardee: Dr. Sogol Mostoufi-Moab Children s Hospital of Philadelphia University of Pennsylvania Risk of Chronic Endocrine Disorders in Adult Survivors of Childhood Cancer
7 CCSS Career Development Award Travel Awardees: Dr. Rebecca Howell UT MD Anderson Cancer Center Radiation Dose Reconstruction Methods for Intensity Modulated Radiation Therapy Dr. Philip Lupo Texas Children s Hospital Baylor College of Medicine Epigenomic Profiling of Metabolic Outcomes in Childhood Leukemia Survivors
8 CCSS as a Resource 204 Publications (13 submitted papers) 36 Funded ancillary studies (over $25,000,000) Over 250 investigators involved in CCSS research projects 45 individuals have utilized CCSS as part of their training
9 CCSS Publications Abstracts Manuscripts
10 CCSS Publications Abstracts Manuscripts
11 Funding U24-CA55727 (Years 18-22) Current Grant Year 19 (12/1/2012 to 11/30/2013) Award provided in two 6-month blocks 12/1/2012 to 5/31/2013 Full Funding 6/1/2013 to 11/30/ % cut ($252K) Reduced stipend to attend 2013 Investigator Meeting Maintain modest institutional funding No Exec. Committee/Working Group Chairs for 2 nd 6-mos St. Jude Institutional Cost-sharing of Coordinating Center Maintain support for Radiation Dosimetry Center Maintain support for Biostatistics and Data Center
12 Institutional Participation in Research Create an institutionally-based roster of individuals interested in participating in CCSSbased research: Faculty, Staff, Trainees Current CV Topics of research interest Availability and desired role Request following the Memphis meeting
13 Minority Participation in CCSS Cohort Provisional Institutions to increase the number of ethnically and racially diverse participants in the expanded cohort Institution/PI Survivor Pool % Minority Children s Hospital Orange Country/ L. Sender % Cook Children s Hospital Dallas/ P. Bowman % Northwestern University/ K. Dilley University of Chicago/ T. Henderson % % Minority Population Hispanic : Asian : Black (25:5:1) Hispanic : Black (3:1) Hispanic : Black (2.3:1) Black : Hispanic (4:1)
14 Minority Task Force G. Armstrong (Chair) Previous Grant Review: Weakness related to the number of minority participant and the potential underrepresentation of minorities. Collaboration with researchers in the Department of Preventive Medicine, University of Southern California Recommendations on minority recruitment and retention.
15 Transition of Leadership Consideration of Leadership with Respect to: Maintaining Current Momentum The Next Competitive Renewal Grant The Long term Future of the Project
16 Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Les Robison 1994-Present Co-Principal Investigator Melissa Hudson 2012-Present Project Director Greg Armstrong 2005-Present Cancer Control Working Group Kevin Oeffinger 2008-Present Chronic Disease Working Group Chuck Sklar 1994-Present Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
17 Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Les Robison 1994-Present Co-Principal Investigator Melissa Hudson 2012-Present Project Director Greg Armstrong 2005-Present Cancer Control Working Group Kevin Oeffinger 2008-Present Chronic Disease Working Group 2013 Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
18 Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Les Robison 1994-Present Co-Principal Investigator Melissa Hudson 2012-Present Project Director Greg Armstrong 2005-Present Cancer Control Working Group Chronic Disease Working Group Kevin Oeffinger 2013 (July) Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
19 Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Les Robison 1994-Present Co-Principal Investigator Melissa Hudson 2012-Present Project Director Greg Armstrong 2005-Present Cancer Control Working Group Chronic Disease Working Group Kevin Oeffinger 2013 Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
20 Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Les Robison 1994-Present Co-Principal Investigator Melissa Hudson 2012-Present Project Director Greg Armstrong 2005-Present Cancer Control Working Group Paul Nathan 2013 (July) Chronic Disease Working Group Kevin Oeffinger 2013 (July) Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
21 Future Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Les Robison 1994-Present Co-Principal Investigator Melissa Hudson 2012-Present Project Director Greg Armstrong 2005-Present Cancer Control Working Group Paul Nathan 2013 Chronic Disease Working Group Kevin Oeffinger 2013 Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
22 Future Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Les Robison Co-Principal Investigator Melissa Hudson 2012-Present Project Director Greg Armstrong 2005-Present Cancer Control Working Group Paul Nathan 2013 Chronic Disease Working Group Kevin Oeffinger 2013 Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
23 Future Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Mid Co-Principal Investigator Melissa Hudson 2012-Present Project Director Greg Armstrong 2005-Present Cancer Control Working Group Paul Nathan 2013 Chronic Disease Working Group Kevin Oeffinger 2013 Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
24 Future Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Greg Armstrong Mid Co-Principal Investigator Melissa Hudson 2012-Present Project Director 2014 Cancer Control Working Group Paul Nathan 2013 Chronic Disease Working Group Kevin Oeffinger 2013 Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
25 Future Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Greg Armstrong Mid Co-Principal Investigator Melissa Hudson 2012-Present Project Director To be identified 2014 Cancer Control Working Group Paul Nathan 2013 Chronic Disease Working Group Kevin Oeffinger 2013 Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
26 Future Transition of Leadership Position Current Individual(s) Tenure Principal Investigator Greg Armstrong Mid Co-Principal Investigator Melissa Hudson 2012-Present Project Director To be identified 2014 Cancer Control Working Group Paul Nathan 2013 Chronic Disease Working Group Kevin Oeffinger 2013 Epidemiology/Biostatistics Working Group (co-chairs) Ann Mertens Wendy Leisenring 1994-Present 2004-Present Genetics Working Group Smita Bhatia 2009-Present Psychology Working Group Kevin Krull 2008-Present Second Malignancy Working Group Joe Neglia 2008-Present
27 Founding Member of CCSS Chronic Disease Working Group Chair since 1994 Executive/Steering Committee since 1994 Institutional Principal Investigator since 1994 Author of 64 CCSS publications
CCSS Investigator Meeting Principal Investigator Report. June 10, 2015 Arlington, VA
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