Systematic reviews and meta-analyses of observational studies (MOOSE): Checklist.
|
|
- Preston Arnold
- 5 years ago
- Views:
Transcription
1 Systematic reviews and meta-analyses of observational studies (MOOSE): Checklist. MOOSE Checklist Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease: a systematic review and meta analysis. Criteria Brief description of how the criteria were handled in the meta analysis Reporting of background should include Problem definition Hospitalization and surgery are markers of inflammatory bowel disease (IBD) severity and significantly contribute to the high economic burden of IBD. Hypothesis statement Infliximab therapy was suggested to reduce the rate of serious complications in IBD (hospitalization and surgery rate). Description of study outcomes We aimed to perform a systematic review and meta analysis of all studies (observational and experimental) that evaluated patients with IBD treated with infliximab and incidence of hospitalizations and surgery. Secondary outcome described in Methods section. Type of exposure or intervention used Infliximab (any dose or regimen) Type of study designs used All studies (observational and experimental) Study population Adult patients (aged 18 years or older) with IBD, irrespective of IBD severity, baseline diseases and risk factors. Reporting of search strategy should include Qualifications of searchers The credentials of investigators are indicated in the author list. 1
2 Search strategy, including time period included in the synthesis and keywords PubMed, from inception April Cochrane Library, from inception April Web of Science with Conference Proceedings, from inception April Databases and registries searched Search strings are supplied in appendix Medline through PubMed, CENTRAL at Cochrane Library and Web of Science with Conference Proceedings. Search software used, name and version, including special features No software was involved in search method Use of hand searching We performed handsearch of references from obtained studies. List of citations located and those excluded, including justifications Method of addressing articles published in languages other than English Method of handling abstracts and unpublished studies Description of any contact with authors Present in the flowchart. No language restrictions were applied. Abstracts contained pretended data. We did not contact any author. Reporting of methods should include Description of relevance or appropriateness of studies assembled for assessing the hypothesis to be tested Rationale for the selection and coding of data Detailed inclusion and exclusion criteria were described in the Methods section. Authors extracted data from study design, location, timeframe of study, patients characteristics, drugs used and its assessment, studies primary outcome, data of required outcomes and estimates adjustments. Assessment of confounding We made subgroup analysis according to IBD type and we explored different sources of heterogeneity. 2
3 Assessment of study quality, including blinding of quality assessors; stratification or regression on possible predictors of study results Quality of reporting was analyzed using a qualitative classification according to risk of bias (high, unclear or low risk). For observational studies we used a 6 items classification based on MOOSE, QATSO and STROBE. This system was adapted from previous published systematic review. For RCTs we adopted Cochrane Collaboration s Tool for assessing risk bias. Assessment of heterogeneity Statistical heterogeneity was evaluated using I 2 statistics. Description of statistical methods in sufficient detail to be replicated Provision of appropriate tables and graphics Description of methods of meta analyses, subgroup analyses, NNT calculations and assessment of publication bias are present in Methods section. We provided 1 flowchart figure and 2 figures with forest plots of outcomes. For supplementary section we provided 4 figures with quality appraisal graphs (2 for RCTs and 2 for observational studies). We supplied 2 tables with studies characteristics: one for RCTs and one for observational studies. Reporting of results should include Graph summarizing individual study estimates and overall estimate Table giving descriptive information for each study included Results of sensitivity/subgroup testing Figure 2 and 3. Table 1 and 2. Figure 2 and 3. Indication of statistical uncertainty of findings 95% confidence intervals were presented with all summary estimates and I 2 values. Reporting of discussion should include Quantitative assessment of bias Quality of studies and the potential impact of bias in results were discussed. Subgroups analyses for surgery rate indicate that CD patients are more likely to benefit with infliximab 3
4 treatment. Justification for exclusion We excluded studies that did not evaluate pretended outcomes or infliximab therapy, studies that included pediatric population and case series studies or studies with a sample size population smaller that pre established. Assessment of quality of included studies Overall quality of included studies was considered to be good. The higher risk of bias was found for potential selective reporting and failure to describe withdrawals in RCTs and presentation of unadjusted risk estimates in observational studies. Reporting of conclusions should include Consideration of alternative explanations for observed results We discussed the limitations inherent to individual studies (selective reporting, unadjusted risk estimates) and metaanalysis (pooling data of studies with different designs, settings and baseline morbidities and heterogeneous risk for hospitalizations and surgery) that could bias observed results. Generalization of the conclusions Our results suggest an important role of infliximab treatment in hospitalization and surgery (at least for CD patients) risk reduction. Guidelines for future research Specific designed prospective long term effectiveness studies are required to establish definite conclusions and to better estimate the true magnitude of this impact. Future studies should also use active controls to inform comparative effectiveness. Disclosure of funding source Disclosure of funding source was made. 4
5 Systematic reviews and meta-analyses of randomized controlled trials (PRISMA): Checklist. PRISMA Checklist Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease: a systematic review and meta-analysis. Section/topic # Checklist item Page TITLE Title 1 Identify the report as a systematic review, meta-analysis, or both. Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease: a systematic review and meta-analysis. 1 ABSTRACT Structured summary 2 Provide a structured summary including, as applicable: background; objectives; data sources; study eligibility criteria, participants, and interventions; study appraisal and synthesis methods; results; limitations; conclusions and implications of key findings; systematic review registration number. OBJECTIVE: To systematically review interventional and observational studies evaluating patients with inflammatory bowel disease (IBD) treated with infliximab to estimate their risk of hospitalizations and surgery. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Medline through PubMed, Cochrane Library and Web of Science with Conference Proceedings from inception to April Systematic reviews and references of retrieved articles were comprehensively searched. STUDY SELECTION: Two reviewers independently selected clinical trials and observational studies evaluating IBD patients treated with infliximab and reporting on hospitalization and/or surgery rate, and retrieved studies characteristics and data estimates. DATA SYNTHESIS: Primary and secondary outcomes were incidence of hospitalization and surgery. Analyses were carried according to study design (randomized clinical trials RCTs, and observational studies) and IBD type (Crohn s 5 2, 3
6 INTRODUCTION disease [CD] and ulcerative colitis [UC]). Random-effects meta-analysis was used to derive pooled and 95% confidence intervals estimates of odds ratios (OR). Heterogeneity was assessed with I 2 test. RESULTS: Twenty-seven eligible studies were included (9 RCTs and 18 observational studies). Infliximab significantly reduced hospitalization risk, both in pooled RCTs (OR 0.51, 95% CI ; I 2 =0%) and observational studies results (OR 0.29, 95% CI ; I 2 =87%), without differences between CD and UC patients. Infliximab also significantly reduced surgery risk in pooled RCTs results (OR 0.36, 95% CI ; I 2 =65%), both in CD and UC patients. Pooled estimate from observational studies favored infliximab for CD (OR 0.30, 95% CI ; I 2 =78%), but not for UC patients. CONCLUSIONS: The best evidence available points towards a reduction of the risk of hospitalization and surgery requirement in IBD patients treated with infliximab. This impact is clinically and economically relevant because hospitalization and surgery are considered to be markers of disease severity and significantly contribute to the total direct costs associated with IBD. Rationale 3 Describe the rationale for the review in the context of what is already known. The requirement for hospitalization and surgery are both currently thought to be markers of IBD severity. Furthermore, medical and surgical hospitalizations positivity impact significantly on the globally high economic burden of IBD. In IBD, infliximab therapy has been claimed to be associated with a reduction of serious complications, such as hospitalization and surgery rate. However, contradictory findings have been reported and uncertainty exists regarding the true magnitude of this putative impact. 5, 6 Objectives 4 Provide an explicit statement of questions being addressed with reference to participants, interventions, comparisons, outcomes, and study design (PICOS). We aimed to perform a systematic review and meta-analysis of all studies (experimental and observational) evaluating IBD patients treated with infliximab and providing data on the rate of serious complications (hospitalizations and/or surgery). PICOS: Participants: Adult patients (aged 18 years or older) with IBD, irrespective of IBD severity, baseline diseases and risk factors. 6 6
7 Interventions: Infliximab. Comparison: Infliximab vs. placebo, no treatment or other active non-biologic drug, adherence vs. non-adherence to infliximab therapy and schedule/persistence maintenance vs. episodic/nonpersistence infliximab therapy. Outcomes: Hospitalization related to IBD (primary) and global (abdominal and/or anal) surgery rate, colectomy rate and hospitalization length (secondary). Study designs: longitudinal studies (RCTs, cohort, case-control and pre-post exposure to infliximab studies). METHODS Protocol and registration 5 Indicate if a review protocol exists, if and where it can be accessed (e.g., Web address), and, if available, provide registration information including registration number. Not a registered systematic review. - Eligibility criteria 6 Specify study characteristics (e.g., PICOS, length of follow-up) and report characteristics (e.g., years considered, language, publication status) used as criteria for eligibility, giving rationale. We considered both experimental (RCTs) and observational studies (prospective or retrospective cohorts including retrospective analyses of medical claims, case-control or pre-post exposure to infliximab). All types of studies participants were allowed irrespective of IBD severity, baseline diseases and risk factors. Only studies evaluating adult patients (aged 18 years or older) were considered. Accepted comparisons included infliximab (any dose and/or regime) vs. placebo, no treatment or other active non-biologic drug, adherence vs. non-adherence to infliximab therapy and schedule/persistence maintenance vs. episodic/nonpersistence infliximab therapy. Cohort studies could be based on ambulatory or institution/hospital population and had to follow patients to determine hospitalization or surgery outcomes. In case-control studies, cases had to be defined as IBD patients with pretended outcomes identified through clinical or by database codes. Controls should be matched to cases, and they should not have any of those outcomes. 6, 7 We included published studies retrieved in databases from inception until April Information sources 7 Describe all information sources (e.g., databases with dates of coverage, contact with study authors to identify additional studies) in the search and date last searched. 7
8 Medline through PubMed (inception-april 2012) CENTRAL at Cochrane Library (inception-april 2012) Web of Science with Conference Proceedings (inception-april 2012) 7 Handsearch of references from obtained studies. Search 8 Present full electronic search strategy for at least one database, including any limits used, such that it could be repeated. Appendix. Study selection 9 State the process for selecting studies (i.e., screening, eligibility, included in systematic review, and, if applicable, included in the meta-analysis). Studies were identified through computerized database searches. Titles and abstract of obtained records were screened. Selected studies were assessed in full-text to determine its appropriateness for inclusion in the review. Flowchart presented in Figure 1. 7, Figure 1 Data collection process 10 Describe method of data extraction from reports (e.g., piloted forms, independently, in duplicate) and any processes for obtaining and confirming data from investigators. Three authors independently extracted data from study. Data items 11 List and define all variables for which data were sought (e.g., PICOS, funding sources) and any assumptions and simplifications made. Investigators extracted data from study design, location, time-frame of study, patients characteristics, drugs used and its assessment, studies primary outcome, data of required outcomes and estimates adjustments. 7 6, 7, 9 Assumptions/simplifications: 8
9 Our primary outcome was hospitalization related to IBD, independently of its goal. Cases of hospitalization were extracted irrespectively of having been reported as pre-specified outcome or not. We did not aim to evaluate hospitalizations resulting from adverse effects, such as serious infections. Global gastrointestinal surgery rate was our secondary outcome. This was defined as abdominal and/or anal surgery. To perform meta-analysis raw data was firstly converted to OR through classic methods or through Peto s method if one arm had zero-count cell. Risk of bias in individual studies 12 Describe methods used for assessing risk of bias of individual studies (including specification of whether this was done at the study or outcome level), and how this information is to be used in any data synthesis. For observational studies: We used a 6-items classification based on MOOSE, QATSO and STROBE. This system was adapted from previous published systematic review and took the following items into consideration: participants (if any justification was given for the cohort and study reported appropriate inclusion and exclusion criteria), intervention (if participants drugs use was adequately assessed, and not based on self-report), disease (if IBD was assessed by clinical, laboratory, radiologic and endoscopic criteria or through databases codes, and not based on self-report), outcome (if pre-specified) and adjustment for potential prognostic confounders. For RCTs: We adapted Cochrane Collaboration s Tool for assessing risk bias to evaluate reporting quality: randomisation method, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, selective reporting (if pneumonia was a pre-specified outcome) and description of withdrawals. 8 Risk of bias graphs were done using these tools. Summary measures 13 State the principal summary measures (e.g., risk ratio, difference in means). Forest plot were generated to show results of individual studies and combined analysis. These were expressed as OR with 95% CI and stratified according with studies design. 8, 9 9
10 Synthesis of results 14 Describe the methods of handling data and combining results of studies, if done, including measures of consistency (e.g., I 2 ) for each meta-analysis. Forest plot were generated to show results of individual studies and combined analysis. These were expressed as OR with 95% CI and stratified according with studies design. Statistical heterogeneity was evaluated using I 2 statistics. 8, 9 10
SUPPLEMENTARY DATA. Supplementary Figure S1. Search terms*
Supplementary Figure S1. Search terms* *mh = exploded MeSH: Medical subject heading (Medline medical index term); tw = text word; pt = publication type; the asterisk (*) stands for any character(s) #1:
More informationThe QUOROM Statement: revised recommendations for improving the quality of reports of systematic reviews
The QUOROM Statement: revised recommendations for improving the quality of reports of systematic reviews David Moher 1, Alessandro Liberati 2, Douglas G Altman 3, Jennifer Tetzlaff 1 for the QUOROM Group
More informationNetwork Meta-Analysis of the Efficacy of Acupuncture, Alpha-blockers and Antibiotics on
Network Meta-Analysis of the Efficacy of Acupuncture, Alpha-blockers and Antibiotics on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Zongshi Qin, Jiani Wu, Jinhui Tian, Jing Zhou, Yali Liu, Zhishun
More informationEffect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A
Supplementary Information for: Effect of Intermittent versus Chronic Calorie Restriction on Tumor Incidence: A Systematic Review and Meta-Analysis of Animal Studies Running title: Intermittent vs. chronic
More informationStandards for the reporting of new Cochrane Intervention Reviews
Methodological Expectations of Cochrane Intervention Reviews (MECIR) Standards for the reporting of new Cochrane Intervention Reviews 24 September 2012 Preface The standards below summarize proposed attributes
More informationWorkshop: Cochrane Rehabilitation 05th May Trusted evidence. Informed decisions. Better health.
Workshop: Cochrane Rehabilitation 05th May 2018 Trusted evidence. Informed decisions. Better health. Disclosure I have no conflicts of interest with anything in this presentation How to read a systematic
More informationAsthma and Current Intestinal Parasite Infection: Systematic Review and
Asthma and Current Intestinal Parasite Infection: Systematic Review and Meta-Analysis, David Pritchard, John Britton Online Data Supplement Additional Information on Methods Search strategy For the electronic
More informationZhengtao Liu 1,2,3*, Shuping Que 4*, Lin Zhou 1,2,3 Author affiliation:
Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: AMeta-analysis of Prospective Studies Zhengtao Liu 1,2,3*, Shuping Que 4*, Lin Zhou
More informationGATE CAT Intervention RCT/Cohort Studies
GATE: a Graphic Approach To Evidence based practice updates from previous version in red Critically Appraised Topic (CAT): Applying the 5 steps of Evidence Based Practice Using evidence about interventions
More informationAlcohol interventions in secondary and further education
National Institute for Health and Care Excellence Guideline version (Draft for Consultation) Alcohol interventions in secondary and further education NICE guideline: methods NICE guideline Methods
More informationGRADE. Grading of Recommendations Assessment, Development and Evaluation. British Association of Dermatologists April 2018
GRADE Grading of Recommendations Assessment, Development and Evaluation British Association of Dermatologists April 2018 Previous grading system Level of evidence Strength of recommendation Level of evidence
More informationCONSORT 2010 checklist of information to include when reporting a randomised trial*
CONSORT 2010 checklist of information to include when reporting a randomised trial* Section/Topic Title and abstract Introduction Background and objectives Item No Checklist item 1a Identification as a
More informationTable S1- PRISMA 2009 Checklist
Table S1- PRISMA 2009 Checklist Section/topic TITLE # Checklist item Title 1 Identify the report as a systematic review, meta-analysis, or both. 1 ABSTRACT Structured summary 2 Provide a structured summary
More informationMeta Analysis. David R Urbach MD MSc Outcomes Research Course December 4, 2014
Meta Analysis David R Urbach MD MSc Outcomes Research Course December 4, 2014 Overview Definitions Identifying studies Appraising studies Quantitative synthesis Presentation of results Examining heterogeneity
More informationCochrane Breast Cancer Group
Cochrane Breast Cancer Group Version and date: V3.2, September 2013 Intervention Cochrane Protocol checklist for authors This checklist is designed to help you (the authors) complete your Cochrane Protocol.
More informationSYSTEMATIC REVIEW: AN APPROACH FOR TRANSPARENT RESEARCH SYNTHESIS
SYSTEMATIC REVIEW: AN APPROACH FOR TRANSPARENT RESEARCH SYNTHESIS A Case Study By Anil Khedkar, India (Masters in Pharmaceutical Science, PhD in Clinical Research Student of Texila American University)
More informationDatabase of Abstracts of Reviews of Effects (DARE) Produced by the Centre for Reviews and Dissemination Copyright 2017 University of York.
A comparison of the cost-effectiveness of five strategies for the prevention of non-steroidal anti-inflammatory drug-induced gastrointestinal toxicity: a systematic review with economic modelling Brown
More information5-ASA for the treatment of Crohn s disease DR. STEPHEN HANAUER FEINBERG SCHOOL OF MEDICINE, NORTHWESTERN UNIVERSITY, CHICAGO, IL, USA
5-ASA for the treatment of Crohn s disease DR. STEPHEN HANAUER FEINBERG SCHOOL OF MEDICINE, NORTHWESTERN UNIVERSITY, CHICAGO, IL, USA Background RCTs investigating the efficacy of aminosalicylates for
More informationRobert M. Jacobson, M.D. Department of Pediatric and Adolescent Medicine Mayo Clinic, Rochester, Minnesota
How to Conduct a Systematic Review: A Workshop 24 th Annual Primary Care Research Methods & Statistics Conference, San Antonio, Texas Saturday, December 3, 2011 Robert M. Jacobson, M.D. Department of Pediatric
More informationSystematic Review & Course outline. Lecture (20%) Class discussion & tutorial (30%)
Systematic Review & Meta-analysisanalysis Ammarin Thakkinstian, Ph.D. Section for Clinical Epidemiology and Biostatistics Faculty of Medicine, Ramathibodi Hospital Tel: 02-201-1269, 02-201-1762 Fax: 02-2011284
More informationPROSPERO International prospective register of systematic reviews
PROSPERO International prospective register of systematic reviews Closed reduction methods for acute anterior shoulder dislocation [Cochrane Protocol] Kanthan Theivendran, Raj Thakrar, Subodh Deshmukh,
More informationSystematic Reviews and Meta- Analysis in Kidney Transplantation
Systematic Reviews and Meta- Analysis in Kidney Transplantation Greg Knoll MD MSc Associate Professor of Medicine Medical Director, Kidney Transplantation University of Ottawa and The Ottawa Hospital KRESCENT
More informationPROSPERO International prospective register of systematic reviews
PROSPERO International prospective register of systematic reviews High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents and young adults with first
More informationSurveillance report Published: 9 January 2017 nice.org.uk
Surveillance report 2017 Caesarean section (2011) NICE guideline CG132 Surveillance report Published: 9 January 2017 nice.org.uk NICE 2017. All rights reserved. Contents Surveillance decision... 3 Reason
More informationSupplementary Online Content
Supplementary Online Content Stewart LA, Clarke M, Rovers M, et al; PRISMA-IPD Development Group. Preferred reporting items for a systematic review and meta-analysis of individual participant data: the
More informationGATE CAT Case Control Studies
GATE: a Graphic Approach To Evidence based practice updates from previous version in red Critically Appraised Topic (CAT): Applying the 5 steps of Evidence Based Practice Using evidence about aetiology/risk/interventions
More informationAllergen immunotherapy for the treatment of allergic rhinitis and/or asthma
ril 2014 Allergen immunotherapy for the treatment of allergic rhinitis and/or asthma FINAL COMPREHENSIVE RESEARCH PLAN June 2015 Study Team: Systematic Review Unit FINAL COMPREHENSIVE RESEARCH PLAN: Systematic
More informationSystematic Reviews. Simon Gates 8 March 2007
Systematic Reviews Simon Gates 8 March 2007 Contents Reviewing of research Why we need reviews Traditional narrative reviews Systematic reviews Components of systematic reviews Conclusions Key reference
More informationProblem solving therapy
Introduction People with severe mental illnesses such as schizophrenia may show impairments in problem-solving ability. Remediation interventions such as problem solving skills training can help people
More informationGRADE. Grading of Recommendations Assessment, Development and Evaluation. British Association of Dermatologists April 2014
GRADE Grading of Recommendations Assessment, Development and Evaluation British Association of Dermatologists April 2014 Previous grading system Level of evidence Strength of recommendation Level of evidence
More informationNeuRA Sleep disturbance April 2016
Introduction People with schizophrenia may show disturbances in the amount, or the quality of sleep they generally receive. Typically sleep follows a characteristic pattern of four stages, where stage
More informationCombination therapy compared to monotherapy for moderate to severe Alzheimer's Disease. Summary
Combination therapy compared to monotherapy for moderate to severe Alzheimer's Disease Summary Mai 17 th 2017 Background Alzheimer s disease is a serious neurocognitive disorder which is characterized
More informationResults. NeuRA Hypnosis June 2016
Introduction may be experienced as an altered state of consciousness or as a state of relaxation. There is no agreed framework for administering hypnosis, but the procedure often involves induction (such
More informationTraumatic brain injury
Introduction It is well established that traumatic brain injury increases the risk for a wide range of neuropsychiatric disturbances, however there is little consensus on whether it is a risk factor for
More informationGATE CAT Diagnostic Test Accuracy Studies
GATE: a Graphic Approach To Evidence based practice updates from previous version in red Critically Appraised Topic (CAT): Applying the 5 steps of Evidence Based Practice Using evidence from Assessed by:
More informationSchool of Dentistry. What is a systematic review?
School of Dentistry What is a systematic review? Screen Shot 2012-12-12 at 09.38.42 Where do I find the best evidence? The Literature Information overload 2 million articles published a year 20,000 biomedical
More information18/11/2013. An Introduction to Meta-analysis. In this session: What is meta-analysis? Some Background Clinical Trials. What questions are addressed?
In this session: What is meta-analysis? An Introduction to Meta-analysis Geoff Der Unit Statistician MRC/CSO Social and Public Health Sciences Unit, University of Glasgow When is it appropriate to use?
More informationPROSPERO International prospective register of systematic reviews
PROSPERO International prospective register of systematic reviews The effect of probiotics on functional constipation: a systematic review of randomised controlled trials EIRINI DIMIDI, STEPHANOS CHRISTODOULIDES,
More informationAppendix A: Literature search strategy
Appendix A: Literature search strategy The following databases were searched: Cochrane Library Medline Embase CINAHL World Health organisation library Index Medicus for the Eastern Mediterranean Region(IMEMR),
More informationMeta-Analysis. Zifei Liu. Biological and Agricultural Engineering
Meta-Analysis Zifei Liu What is a meta-analysis; why perform a metaanalysis? How a meta-analysis work some basic concepts and principles Steps of Meta-analysis Cautions on meta-analysis 2 What is Meta-analysis
More informationData extraction. Specific interventions included in the review Dressings and topical agents in relation to wound healing.
Systematic reviews of wound care management: (2) dressings and topical agents used in the healing of chronic wounds Bradley M, Cullum N, Nelson E A, Petticrew M, Sheldon T, Torgerson D Authors' objectives
More informationCHECK-LISTS AND Tools DR F. R E Z A E I DR E. G H A D E R I K U R D I S TA N U N I V E R S I T Y O F M E D I C A L S C I E N C E S
CHECK-LISTS AND Tools DR F. R E Z A E I DR E. G H A D E R I K U R D I S TA N U N I V E R S I T Y O F M E D I C A L S C I E N C E S What is critical appraisal? Critical appraisal is the assessment of evidence
More informationMeta-analysen Methodik für Mediziner
Kardiolunch, 11.2.2014 Meta-analysen Methodik für Mediziner PD Dr Matthias Briel Basel Institute for Clin Epi & Biostats, Switzerland McMaster University, Hamilton, Canada Agenda SystematischeReviews &
More informationMINDFULNESS-BASED INTERVENTIONS IN EPILEPSY
03 March 2016; v.1 MINDFULNESS-BASED INTERVENTIONS IN EPILEPSY AIM This review aimed to evaluate the effectiveness of mindfulness as a therapeutic intervention for people with epilepsy. METHODS Criteria
More informationPROGRAMMA DELLA GIORNATA
PROGRAMMA DELLA GIORNATA si riprendono i concetti della volta precedente compiti dati da fare a casa si richiama il programma del corso 1.1.1. Studi integrativi 1.1.2. Revisioni sistematiche 1.1.4.1. TEST
More informationLearning from Systematic Review and Meta analysis
Learning from Systematic Review and Meta analysis Efficacy and Safety of Antiscabietic Agents: A Systematic Review and Network Meta analysis of Randomized Controlled Trials KUNLAWAT THADANIPON, MD 4 TH
More informationResults. NeuRA Worldwide incidence April 2016
Introduction The incidence of schizophrenia refers to how many new cases there are per population in a specified time period. It is different from prevalence, which refers to how many existing cases there
More informationCritical appraisal: Systematic Review & Meta-analysis
Critical appraisal: Systematic Review & Meta-analysis Atiporn Ingsathit MD.PhD. Section for Clinical Epidemiology and biostatistics Faculty of Medicine Ramathibodi Hospital Mahidol University What is a
More informationClinical Epidemiology for the uninitiated
Clinical epidemiologist have one foot in clinical care and the other in clinical practice research. As clinical epidemiologists we apply a wide array of scientific principles, strategies and tactics to
More informationResults. NeuRA Motor dysfunction April 2016
Introduction Subtle deviations in various developmental trajectories during childhood and adolescence may foreshadow the later development of schizophrenia. Studies exploring these deviations (antecedents)
More informationMeta-analyses: analyses:
Meta-analyses: analyses: how do they help, and when can they not? Lee Hooper Senior Lecturer in research synthesis & nutrition l.hooper@uea.ac.uk 01603 591268 Aims Systematic Reviews Discuss the scientific
More informationControlled Trials. Spyros Kitsiou, PhD
Assessing Risk of Bias in Randomized Controlled Trials Spyros Kitsiou, PhD Assistant Professor Department of Biomedical and Health Information Sciences College of Applied Health Sciences University of
More informationResults. NeuRA Treatments for internalised stigma December 2017
Introduction Internalised stigma occurs within an individual, such that a person s attitude may reinforce a negative self-perception of mental disorders, resulting in reduced sense of selfworth, anticipation
More informationWhat is the Cochrane Collaboration? What is a systematic review?
1 What is the Cochrane Collaboration? What is a systematic review? Archie Cochrane (1909-1988) It is surely a great criticism of our profession that we have not organised a critical summary, by specialty
More informationPROSPERO International prospective register of systematic reviews
PROSPERO International prospective register of systematic reviews Prophylactic cranial irradiation in patients with non-small-cell lung cancer: a systematic review and meta-analysis of randomized controlled
More informationPROSPERO International prospective register of systematic reviews
PROSPERO International prospective register of systematic reviews Drug-eluting balloon angioplasty versus non-stenting balloon angioplasty for peripheral arterial disease of the lower limbs [Cochrane Protocol]
More informationWeb Annex 3.1. Adult hepatitis C virus treatment systematic review
Web Annex 3.. Adult hepatitis C virus treatment systematic review Michael Zoratti, Hamilton, Canada In: Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection
More informationIntroduction to systematic reviews/metaanalysis
Introduction to systematic reviews/metaanalysis Hania Szajewska The Medical University of Warsaw Department of Paediatrics hania@ipgate.pl Do I needknowledgeon systematicreviews? Bastian H, Glasziou P,
More informationResults. NeuRA Mindfulness and acceptance therapies August 2018
Introduction involve intentional and non-judgmental focus of one's attention on emotions, thoughts and sensations that are occurring in the present moment. The aim is to open awareness to present experiences,
More informationImproving reporting for observational studies: STROBE statement
Improving reporting for observational studies: STROBE statement Technical meeting on the reporting of human studies submitted for the scientific substantiation of health claims EFSA Parma 20 November 2013
More informationDistraction techniques
Introduction are a form of coping skills enhancement, taught during cognitive behavioural therapy. These techniques are used to distract and draw attention away from the auditory symptoms of schizophrenia,
More informationTitle 1 Descriptive title identifying the study design, population, interventions, and, if applicable, trial acronym
SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents* Section/item Item No Description Addressed on page number Administrative information Title 1 Descriptive
More informationOutcomes assessed in the review
The effectiveness of mechanical compression devices in attaining hemostasis after removal of a femoral sheath following femoral artery cannulation for cardiac interventional procedures Jones T Authors'
More informationAnimal-assisted therapy
Introduction Animal-assisted interventions use trained animals to help improve physical, mental and social functions in people with schizophrenia. It is a goal-directed intervention in which an animal
More informationEvidence Based Medicine
Course Goals Goals 1. Understand basic concepts of evidence based medicine (EBM) and how EBM facilitates optimal patient care. 2. Develop a basic understanding of how clinical research studies are designed
More informationResults. NeuRA Treatments for dual diagnosis August 2016
Introduction Many treatments have been targeted to improving symptom severity for people suffering schizophrenia in combination with substance use problems. Studies of dual diagnosis often investigate
More informationDownloaded from:
Arnup, SJ; Forbes, AB; Kahan, BC; Morgan, KE; McKenzie, JE (2016) The quality of reporting in cluster randomised crossover trials: proposal for reporting items and an assessment of reporting quality. Trials,
More informationManagement of new onset atrial fibrillation McNamara R L, Bass E B, Miller M R, Segal J B, Goodman S N, Kim N L, Robinson K A, Powe N R
Management of new onset atrial fibrillation McNamara R L, Bass E B, Miller M R, Segal J B, Goodman S N, Kim N L, Robinson K A, Powe N R Authors' objectives To synthesise the evidence that exists to guide
More informationThe Effect of Vocational Rehabilitation on Return-to-Work Rates in Adults with Stroke
The Effect of Vocational Rehabilitation on Return-to-Work Rates in Adults with Stroke Prepared by: Pauline Koh (email address: pauline.koh@alumni.ubc.ca) Date: 8 March 2018 Review date: 8 March 2020 CLINICAL
More informationAppendix 2 Quality assessment tools. Cochrane risk of bias tool for RCTs. Support for judgment
Appendix 2 Quality assessment tools Cochrane risk of bias tool for RCTs Item Judgment (H/L/Unclear) Random sequence generation (selection bias) Allocation concealment (selection bias) Blinding of participants
More informationInstrument for the assessment of systematic reviews and meta-analysis
Appendix II Annex II Instruments for the assessment of evidence As detailed in the main body of the methodological appendix (Appendix II, "Description of the methodology utilised for the collection, assessment
More informationResults. NeuRA Forensic settings April 2016
Introduction Prevalence quantifies the proportion of individuals in a population who have a disease during a specific time period. Many studies have reported a high prevalence of various health problems,
More information1. Draft checklist for judging on quality of animal studies (Van der Worp et al., 2010)
Appendix C Quality appraisal tools (QATs) 1. Draft checklist for judging on quality of animal studies (Van der Worp et al., 2010) 2. NICE Checklist for qualitative studies (2012) 3. The Critical Appraisal
More informationComponent of CPG development ILAE Recommendation Document Identifying topic and developing clinical. S3 research question
S1: Summary of recommendations for developing Clinical Practice Guidelines Minimum CPG development requirements (where resources are more limited) are bolded. When full resources are available, every recommendation
More informationAppendix Document A1: Search strategy for Medline (1960 November 2015)
Appendices: Appendix Document A1: Search strategy for Medline (1960 November 2015) Appendix Table A1: Detailed Risk of Bias Table Appendix Figure A1: Funnel plot Appendix Figure A2: Sensitivity analysis
More informationResearch Synthesis and meta-analysis: themes. Graham A. Colditz, MD, DrPH Method Tuuli, MD, MPH
Research Synthesis and meta-analysis: themes Graham A. Colditz, MD, DrPH Method Tuuli, MD, MPH Today Course format Goals, competencies Overview of themes for the class SRMA M19-551 Course Format Lectures»
More informationRandomized Controlled Trial
Randomized Controlled Trial Training Course in Sexual and Reproductive Health Research Geneva 2016 Dr Khalifa Elmusharaf MBBS, PgDip, FRSPH, PHD Senior Lecturer in Public Health Graduate Entry Medical
More informationA Systematic Review of the Efficacy and Clinical Effectiveness of Group Analysis and Analytic/Dynamic Group Psychotherapy
A Systematic Review of the Efficacy and Clinical Effectiveness of Group Analysis and Analytic/Dynamic Group Psychotherapy Executive summary Aims of the review The main aim of the review was to assess the
More informationMonth/Year of Review: September 2012 Date of Last Review: September 2010
Copyright 2012 Oregon State University. All Rights Reserved Drug Use Research & Management Program Oregon State University, 500 Summer Street NE, E35, Salem, Oregon 97301-1079 Phone 503-947-5220 Fax 503-947-1119
More informationSystematic review with multiple treatment comparison metaanalysis. on interventions for hepatic encephalopathy
Systematic review with multiple treatment comparison metaanalysis on interventions for hepatic encephalopathy Hepatic encephalopathy (HE) is a reversible neuropsychiatric syndrome associated with severe
More informationSystematic Reviews and Meta-analysis in Aquatic therapy
Systematic Reviews and Meta-analysis in Aquatic therapy Prof. Daniel Daly Ben Waller PT, MSc 2nd European Congress on Evidence Based Aquatic Therapy Wednesday 15th April 2015 Systematic Review A systematic
More informationThe Cochrane Collaboration, the US Cochrane Center, and The Cochrane Library
The Cochrane Collaboration, the US Cochrane Center, and The Cochrane Library Kay Dickersin, PhD Association for Population/Family Planning Libraries & Information Centers International Boston, Ma 30 March
More informationBackground: Traditional rehabilitation after total joint replacement aims to improve the muscle strength of lower limbs,
REVIEWING THE EFFECTIVENESS OF BALANCE TRAINING BEFORE AND AFTER TOTAL KNEE AND TOTAL HIP REPLACEMENT: PROTOCOL FOR A SYSTEMATIC RE- VIEW AND META-ANALYSIS Background: Traditional rehabilitation after
More informationCochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library)
A systematic review of smoking cessation and relapse prevention interventions in parents of babies admitted to a neonatal unit (after delivery) Divya Nelson, Sarah Gentry, Caitlin Notley, Henry White,
More informationACR OA Guideline Development Process Knee and Hip
ACR OA Guideline Development Process Knee and Hip 1. Literature searching frame work Literature searches were developed based on the scenarios. A comprehensive search strategy was used to guide the process
More informationAppendices. Appendix A Search terms
Appendices Appendix A Search terms Database Search terms Medline 1. Ipilimumab; 2. MDX-010; 3. MDX-101; 4. Yervoy; 5. BMS-734016; 6. Nivolumab; 7. ONO-4538; 8. BMS-936558; 9. MDX-1106; 10. Opdivo; 11.
More informationA systematic review of treatments for severe psoriasis Griffiths C E, Clark C M, Chalmers R J, Li Wan Po A, Williams H C
A systematic review of treatments for severe psoriasis Griffiths C E, Clark C M, Chalmers R J, Li Wan Po A, Williams H C Authors' objectives To compare the effectiveness of currently available treatments
More informationUSDA Nutrition Evidence Library: Systematic Review Methodology
USDA Nutrition Evidence Library: Systematic Review Methodology Julie E. Obbagy, PhD, RD USDA Center for Nutrition Policy & Promotion Meeting #2 October 17, 2016 The National Academies of Sciences, Engineering,
More informationThe treatment of postnatal depression: a comprehensive literature review Boath E, Henshaw C
The treatment of postnatal depression: a comprehensive literature review Boath E, Henshaw C Authors' objectives To evalute treatments of postnatal depression. Searching MEDLINE, PsycLIT, Sociofile, CINAHL
More informationCritical Appraisal of a Meta-Analysis: Rosiglitazone and CV Death. Debra Moy Faculty of Pharmacy University of Toronto
Critical Appraisal of a Meta-Analysis: Rosiglitazone and CV Death Debra Moy Faculty of Pharmacy University of Toronto Goal To provide practitioners with a systematic approach to evaluating a meta analysis
More informationThe objective of this systematic review is to assess the impact of migration on the risk of developing gastric cancer.
Review title The effect of migration on gastric cancer risk: A systematic review protocol Reviewers Haejin In, MD, MBA, MPH 1 Marisa Langdon-Embry, MS 2 1 Albert Einstein College of Medicine, haejin.in@einstein.yu.edu
More informationMSc Programme in International Health Epidemiology and Statistics. Before lecture exercise. Aims of the lecture
MSc Programme in International Health Epidemiology and Statistics Why was the advert for Actimel banned by the ASA? Lecture 9 1 Before lecture exercise Select 10 red tiles and 10 blue tiles at random from
More informationMeta-analysis: Methodology
Meta-analysis: Methodology Example: Assessment of cardiovascular safety profile of new generation BCR-ABL TKIs in patients with CML Haguet Hélène 04/03/2016 Meta-analysis = statistical combination of results
More informationCochrane Pregnancy and Childbirth Group Methodological Guidelines
Cochrane Pregnancy and Childbirth Group Methodological Guidelines [Prepared by Simon Gates: July 2009, updated July 2012] These guidelines are intended to aid quality and consistency across the reviews
More informationMeta-Analyses: Considerations for Probiotics & Prebiotics Studies
Meta-Analyses: Considerations for Probiotics & Prebiotics Studies Daniel J. Tancredi, PhD Associate Professor in Residence Department of Pediatrics UC Davis School of Medicine Objectives Provide an overview
More informationRecent developments for combining evidence within evidence streams: bias-adjusted meta-analysis
EFSA/EBTC Colloquium, 25 October 2017 Recent developments for combining evidence within evidence streams: bias-adjusted meta-analysis Julian Higgins University of Bristol 1 Introduction to concepts Standard
More informationSystematic reviews and meta-analyses are essential tools. Academia and Clinic
Annals of Internal Medicine Academia and Clinic The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: and Elaboration Alessandro Liberati,
More informationAmerican Journal of Internal Medicine
American Journal of Internal Medicine 2016; 4(3): 49-59 http://www.sciencepublishinggroup.com/j/ajim doi: 10.11648/j.ajim.20160403.12 ISSN: 2330-4316 (Print); ISSN: 2330-4324 (Online) The Effect of Dose-Reduced
More informationSystematic Review of RCTs of Haemophilus influenzae Type b Conjugate Vaccines: Efficacy and immunogenicity
Supplementary text 1 Systematic Review of RCTs of Haemophilus influenzae Type b Conjugate Vaccines: Efficacy and immunogenicity Review protocol Pippa Scott, Shelagh Redmond, Nicola Low and Matthias Egger
More informationPrinciples of meta-analysis
Principles of meta-analysis 1 The popularity of meta-analyses Search on 22 October 2015 10000 9000 8156 8875 8000 7000 6554 6000 5000 4852 4000 3000 2000 1000 0 1 1 1 272 334 371 323 386 429 482 596 639
More information