Jessica Philpott MD PhD Digestive Diseases Institute Cleveland Clinic
|
|
- April Stone
- 5 years ago
- Views:
Transcription
1 Jessica Philptt MD PhD Digestive Diseases Institute Cleveland Clinic
2 Objectives Review the Crhn s and Clitis Fundatin Challenges t Research Gals 2018 Review data in envirnment and genetics as cntributing t disease develpment Review rle f bacterial flra in IBD Discuss new paradigms in assessing therapeutic utcmes Discuss nvel technlgies
3 Challenges in IBD Research 2018* Preclinical human factrs Envirnmental factrs Nvel technlgies Precisin Medicine Clinical Research Gal: Identify unmet areas f knwledge t imprve utcmes fr patients
4 Challenges in IBD Research 2018* Preclinical human factrs What makes sme peple get IBD and makes their IBD severe? Genetics Immunlgy Envirnmental factrs-culd we change what we eat r are expsed t in rder t cure r avid IBD? Diet Intestinal flra Fd additives Nvel technlgies-what else d we need t better treat IBD? Unmet needs Precisin Medicine Hw can we best tailr treatment t each individual patient? Clinical Research-Hw can we make sure studies are dne that we can quickly apply t ur patients? Pragmatic studies
5 Interactin f multiple factrs impact develpment f IBD
6 Preclinical Factrs: Genetics Ye et al,expert Rev Clin Immunl Oct; 12(10):
7 Preclinical factrs: envirnment Csnes, Gastr Vlume 140, Issue 6, Pages e4 (May 2011)
8 Suspects Diet Hygiene thery Tbacc use Vaccines Change in micrbita
9 Randmized cntrlled trials
10 Envirnment: Diet Exclusive enteral nutritin has been shwn t reduce inflammatin in children with Crhn s disease, but is inferir t sterids The Specific Carbhydrate Diet (SCD) is ne that restricts all carbhydrates except mnsaccarides Uncntrlled study in children shwed imprvement in mucsal healing with SCD Other carbhydrate restricted diets such as the AIP (Autimmune prtcl-pale) have been studied in small grups already n ther treatment with imprvement but few with strictures suffered frm bwel bstructin In 2018 we dn t have adequate evidence t recmmend a diet t treat inflammatin but we hpe t sn CARBs prbably key ***Lewis and Abreu, Gastrenterlgy 152: Knijieti, Inflamm Bwel Dis Nv; 23(11):
11 Envirnment: bacteria in the intestines Dysbisis: an unfavrable alteratin f the cmpsitin and gut micrbita Rle f bacteria in the intestines Nutrient synthesis and delivery Immune system regulatin and develpment Hst defense Nishida et al Clinical Jurnal f Gastrenterlgy February 2018, Vlume 11, Issue 1, pp 1 10
12 Davenprt et al, Inflamm Bwel Dis Apr; 20(4):
13 Shuld we try t change the bacterial micrbita and if s, hw? Are the bacteria altered because the gut is injured/the immune system dysfunctinal r d the altered flra CAUSE disease?(chicken r the egg) Antibitics: n data suggesting strng effect t directly treat Crhn s and Ulcerative clitis Prbitics: insufficient data,? Rle in additin t traditinal therapy in UC Fecal micrbacteritherapy (FMT) Diet
14 Precisin medicine An emerging apprach fr disease treatment and preventin that takes int accunt individual variability in genes, envirnment, and lifestyle fr each persn Tailr IBD therapy t each individual patient t ptimize their clinical utcmes Predict risk f medicines used and risk f disease prgressin Predict respnse t medicatin Detect respnse t medicatin and detect when medicatin change in needed
15 What is ur treatment target? What shuld be ur gal: nt just treat symptms but als attempt t heal mucsal inflammatin Mucsal healing has been shwn t be assciated with lwer risk f need fr sterids, surgery and cancer Treating t target is a attempt at using bjective data t guide therapy and t adjust therapy based n evidence f inflammatin Neurath, Gut, / Vlume 61, Issue 11;Buguen, Clinical Gastrenterlgy and Hepatlgy 2015;13:
16 CALM study Attempt t cmpare escalatin f therapy n schedule based n lab parameters suggesting nging inflammatin cmpared t adjusting therapy based n clinical symptms The primary utcme is mucsal healing and sterid free remissin is a secndary utcme at 48 mnths. We dn t knw hw these patients will d lng term. What makes these patients different that the average Crhn s patient They have never been treated with bilgics r immunsuppressives befre
17 CALM study Clumbel et al Lancet Dec 23;390(10114):
18
19 Nvel technlgies Bimarkers: when can we d a stl r bld test t avid endscpy t find ut if the disease is effectively treated? Endscpic therapy fr IBD: when can we safely intervene endscpically t avid a surgery -Dysplasia in UC-can precancerus areas be resected? -Strictures in CD and puchitis Use f drug level mnitring
20 FDA apprvals fr IBD meds
21 Many pathways t target Valatas AJP Gastr Liver Phys 2013
22 Multitude f pathways targeted by new medicatins JAK/STAT Anti IL23/ p19 (psriasis) Tfacitinib (Xeljanz) Brazikumab (CD) Filgtinib (CD) Risankizumab (CD) Upadacitinib Mirikizumab (UC) Upadacitinib Sphingsine-1- Cell trafficking/antiintegrin phsphate receptr inhibitin Finglimd Etrlizumab Ozanimd Etrasimd Befre 2014 the nly FDA apprved bilgics we had targeted just ne pathway: TNF-alpha
23 Rates f Primary and Majr Secndary End Pints at 8 Weeks in the Mdified Intentin-t-Treat Ppulatin, Accrding t Study Grup. Sandbrn WJ et al. N Engl J Med 2012;367:
24 Thank yu!
Health Science Ch. 16 Cancer Lecture Outline
Cancer Leading cause f disease-related death amng peple under age 75 Secnd leading cause f death Evidence supprts that mst cancers culd be prevented by simple lifestyle changes Tbacc is respnsible fr abut
More informationEXECUTIVE SUMMARY INNOVATION IS THE KEY TO CHANGING THE PARADIGM FOR THE TREATMENT OF PAIN AND ADDICTION TO CREATE AN AMERICA FREE OF OPIOID ADDICTION
EXECUTIVE SUMMARY INNOVATION IS THE KEY TO CHANGING THE PARADIGM FOR THE TREATMENT OF PAIN AND ADDICTION TO CREATE AN AMERICA FREE OF OPIOID ADDICTION The Bitechnlgy Innvatin Organizatin (BIO) and ur member
More informationALCAT FREQUENTLY ASKED QUESTIONS
1. Is fasting required befre taking the Alcat Test? N. It is recmmended t drink water and t avid stimulants like caffeine prir t the test. 2. With regard t testing children, must a child be a certain age
More informationSocial Learning Theories
Scial Learning Theries - Careful scientific prcedures and methdlgy that characterize the behaviurist apprach Albert Bandura - Brn in small twn Alberta - Plish decent - Only sn with 5 sisters - Interested
More informationReferral Criteria: Inflammation of the Spine Feb
Referral Criteria: Inflammatin f the Spine Feb 2019 1 5.7. Inflammatin f the Spine Backgrund Ankylsing spndylitis and axial spndylarthrpathy are fund in arund 0.3-1.2% f the ppulatin. Spndylarthritis encmpasses
More informationRelated Policies None
Medical Plicy MP 3.01.501 Guidelines fr Cverage f Mental and Behaviral Health Services Last Review: 8/30/2017 Effective Date: 8/30/2017 Sectin: Mental Health End Date: 08/19/2018 Related Plicies Nne DISCLAIMER
More informationSignificance of Chronic Kidney Disease in 2015
1 Significance f Chrnic Kidney Disease in 2015 There is still a requirement within QOF t keep a register f peple with CKD stages 3-5. The ther CKD QOF targets have been retired. This is because CKD care
More informationSwindon Joint Strategic Needs Assessment Bulletin
Swindn Jint Strategic Needs Assessment Bulletin Swindn Diabetes 2017 Key Pints: This JSNA gives health facts abut peple with diabetes r peple wh might get diabetes in Swindn. This helps us t plan fr medical
More informationUS Public Health Service Clinical Practice Guidelines for PrEP
Webcast 1.3 US Public Health Service Clinical Practice Guidelines fr PrEP P R E S ENTED BY: M A R K T H R U N, M D A S S O C I AT E P R O F E S S O R, U N I V E R S I T Y O F C O L O R A D O, D I V I S
More informationOsteoporosis Fast Facts
Osteprsis Fast Facts Fast Facts n Osteprsis Definitin Osteprsis, r prus bne, is a disease characterized by lw bne mass and structural deteriratin f bne tissue, leading t bne fragility and an increased
More informationFrequently Asked Questions: IS RT-Q-PCR Testing
Questins 1. What is chrnic myelid leukemia (CML)? 2. Hw des smene knw if they have CML? 3. Hw is smene diagnsed with CML? Frequently Asked Questins: IS RT-Q-PCR Testing Answers CML is a cancer f the bld
More informationThe principles of evidence-based medicine
The principles f evidence-based medicine By the end f this mdule yu shuld be able t: Describe what evidence based medicine is Knw where t find quality evidenced based medicine n the internet Be able t
More informationHuman papillomavirus (HPV) refers to a group of more than 150 related viruses.
HUMAN PAPILLOMAVIRUS This infrmatin may help answer sme f yur questins and help yu think f ther questins that yu may want t ask yur cancer care team; it is nt intended t replace advice r discussin between
More informationDATA RELEASE: UPDATED PRELIMINARY ANALYSIS ON 2016 HEALTH & LIFESTYLE SURVEY ELECTRONIC CIGARETTE QUESTIONS
DATA RELEASE: UPDATED PRELIMINARY ANALYSIS ON 216 HEALTH & LIFESTYLE SURVEY ELECTRONIC CIGARETTE QUESTIONS This briefing has been specifically prepared fr the Ministry f Health t prvide infrmatin frm this
More informationESCHERICHIA COLI. By: Breana Williams
ESCHERICHIA COLI By: Breana Williams DISEASE OVERVIEW Escherichia cli (E. cli) are bacteria that can be fund in the intestines f humans and animals alng with in the envirnment and in fd. There are many
More informationCONTACT: Amber Hamilton TYPE 2 DIABETES AND OBESITY: TWIN EPIDEMICS OVERVIEW
FACT SHEET CONTACT: Amber Hamiltn 212-266-0062 TYPE 2 DIABETES AND OBESITY: TWIN EPIDEMICS OVERVIEW Type 2 diabetes accunts fr 90-95% f the 29.1 millin diabetes cases in the U.S. 1 Obesity is a majr independent
More informationYear 10 Food Technology. Assessment Task 1: Foods for Special Needs. Name: Teacher:
Year 10 Fd Technlgy Assessment Task 1: Fds fr Special Needs Name: Teacher: Due Date: Term 2, Week 1 Type f Task: Design Task Planning Fd Requirements Cllectin f Assessment: Submit in Class Assessment Plicy:
More informationUNIT 2: mapping bananas
Oxfam Educatin www.xfam.rg.uk/educatin UNIT 2: mapping bananas Age range: 7-11 years Outline Learners will investigate sme f the cuntries where the bananas we eat in the UK are grwn. They will first lcate
More informationCommissioning Policy: South Warwickshire CCG (SWCCG)
Cmmissining Plicy: Suth Warwickshire CCG (SWCCG) Treatment Indicatin Criteria FreeStyle Libre Flash Cntinuus Glucse Mnitring System Type I Diabetes Prir apprval must be requested frm the Individual Funding
More informationService Change Process. Gateway 1 High-level Proposition. Innovation project name: Patient Self-Monitoring/Management of Warfarin
Service Change Prcess Gateway 1 High-level Prpsitin Innvatin prject name: Patient Self-Mnitring/Management f Warfarin NHS Bury Please describe the service change being prpsed. Please describe what service(s)
More informationAnnex III. Amendments to relevant sections of the Product Information
Changes t the Prduct infrmatin as apprved by the CHMP n 13 Octber 2016, pending endrsement by the Eurpean Cmmissin Annex III Amendments t relevant sectins f the Prduct Infrmatin Nte: These amendments t
More informationVolume Measurement at CT
Vlume Measurement at CT Staging and Assessment f Respnse with Quantitative CT Lawrence Schwartz, MD Department f Radilgy Clumbia University Cllege f Physicians and Surgens LSCHWARTZ@COLUMBIA.EDU Recmmendatins
More informationUnderstanding Your Total-Cholesterol-to-HDL Ratio
Understanding Yur Ttal-Chlesterl-t-HDL Rati Yur ttal-chlesterl-t-hdl rati is measured during a bld test called a lipid prfile. This wrksheet will help yu learn mre abut this rati. It will als help yu:
More informationIndividual Assessments for Couples Treatment with HFCA
Individual Assessments fr Cuples Treatment with HFCA Jennifer S. Ripley, Ph.D. Many appraches t cuples therapy include an individual assessment whenever a cuple cmes fr treatment. Therapists shuld be aware
More informationHealth Consumers Queensland submission
Health Cnsumers Queensland submissin Inquiry int Public Health (Medicinal Cannabis) Bill 2016 Queensland Parliament Health, Cmmunities, Disability Services and Family Vilence Preventin Cmmittee Cntact:
More informationRheumatoid Arthritis Learning Collaborative Sponsored by AMGF and AbbVie
1 Rheumatid Arthritis Learning Cllabrative Spnsred by AMGF and AbbVie August 12-14, 2015 Ochsner Medical Center Best Practices in Managing patients with Rheumatid Arthritis 2 Medical Grup Prfile When was
More informationNFS284 Lecture 3. How much of a nutrient is required to maintain health? Types and amounts of foods to maintain health
NFS284 Lecture 3 Chapter 2: Nutritin: Guidelines: Applying the Science f Nutritin 2.1 Nutritin Recmmendatin fr the Canadian Diet Nutrient-based apprach Hw much f a nutrient is required t maintain health?
More informationFOUNDATIONS OF DECISION-MAKING...
Table f Cntents FOUNDATIONS OF DECISION-MAKING... Errr! Bkmark nt Describe the decisin-making prcess pp.62-66... Errr! Bkmark nt Explain the three appraches managers can use t make decisins pp.67-70 Errr!
More informationQ 5: Is relaxation training better (more effective than/as safe as) than treatment as usual in adults with depressive episode/disorder?
updated 2012 Relaxatin training Q 5: Is relaxatin training better (mre effective than/as safe as) than treatment as usual in adults with depressive episde/disrder? Backgrund The number f general health
More informationGlaucoma Interviews: Due Tuesday, May 22 nd
Glaucma Interviews: Due Tuesday, May 22 nd 1) Read the glaucma article well! It will explain what it is, plus tell yu sme symptms and risk factrs. Yu may want t use a highlighter r pen t mark imprtant
More informationCDC Influenza Division Key Points MMWR Updates February 20, 2014
CDC Influenza Divisin Key Pints MMWR Updates In this dcument: Summary Key Messages Seasnal Influenza Vaccine Effectiveness: Interim Adjusted Estimates Influenza Surveillance Update: September 29, 2013-February
More informationMeeting the Nutritional Requirements of Individuals with Dementia
Unit 15: Understanding and Meeting the Nutritinal Requirements f Individuals with Dementia Unit reference number: D/616/7124 Level: 3 Unit type: Optinal Credit value: 3 Guided learning hurs: 26 Unit summary
More informationRisk factors in health and disease
Risk factrs in health and disease Index 1 Intrductin 2 Types f risk factrs 2.1 Behaviural risk factrs 2.2 Psychlgical risk factrs 2.3 Demgraphic risk factrs 2.4 Envirnmental risk factrs 2.5 Genetic risk
More information2017 Optum, Inc. All rights reserved BH1124_112017
1) What are the benefits t clients f encuraging the use f MAT? Withut MAT, 90% f individuals with Opiid Use Disrder (OUD) will relapse within ne year. With MAT, the relapse rate fr thse with OUD decreases
More informationARLA FOOD FOR HEALTH 4 th ANNUAL CALL FOR EXPRESSIONS OF INTEREST
ARLA FOOD FOR HEALTH 4 th ANNUAL CALL FOR EXPRESSIONS OF INTEREST 7 th July 2017 Cntent 1 Intrductin 2 Tpics fr EOI in the 4 th call 3 The applicatin prcess and imprtant dates 4 Guideline fr EOIs Deadline
More informationSUBSPECIALIST TRAINING PROGRAMME in GYNAECOLOGICAL ONCOLOGY
EUROPEAN SOCIETY OF GYNAECOLOGICAL ONCOLOGY SUBSPECIALIST TRAINING PROGRAMME in GYNAECOLOGICAL ONCOLOGY Sme 50% f cancers that affect wmen are lcated in the breast r in the genital rgans. Gynaeclgical
More informationThe Interface Between Theory of Mind and Language Impairment
The Interface Between Thery f Mind and Language Impairment By Lauren Lwry Hanen Certified SLP and Clinical Staff Writer When mst f us hear the term thery f mind we usually think abut children with autism
More informationCLINICAL MEDICAL POLICY
Plicy Name: Plicy Number: Respnsible Department(s): CLINICAL MEDICAL POLICY Supervised Exercise Therapy fr Peripheral Artery Disease (PAD) MP-077-MD-DE Medical Management Prvider Ntice Date: 01/15/2019
More informationUnderstanding your thumb osteoarthritis
Understanding yur thumb stearthritis Intrductin The CMC jint is ne f the mst imprtant jints f the thumb and hand due t its wide range f mtin. Over time, the CMC jint is subject t large and repeated frces
More informationAP Biology Immune System. Pathogens: agents that cause disease Immunity: the ability to avoid disease when invaded by a pathogen
AP Bilgy Pathgens: agents that cause disease Immunity: the ability t avid disease when invaded by a pathgen Innate Immunity: nnspecific First line f defense Barriers such as skin Hard fr bacteria t penetrate
More informationImpacts of State Level Dental Hygienist Scope of Practice on Oral Health Outcomes in the U.S. Population
Impacts f State Level Dental Hygienist Scpe f Practice n Oral Health Outcmes in the U.S. Ppulatin Building Trust in Peple and Places C-spnsred by: Prfessinal Standards Authrity Centre fr Trust, Peace and
More informationCDC Influenza Technical Key Points February 15, 2018
CDC Influenza Technical Key Pints In this dcument: Summary Key Pints U.S. Vaccine Effectiveness U.S. Flu Activity Update Summary Key Pints On Thursday, tw influenza-related reprts appeared in the Mrbidity
More informationImproving Surveillance and Monitoring of Self-harm in Irish Prisons
HSE Mental Health Divisin Stewart s Hspital, Palmerstwn, Dublin 20 Tel: 01 6201670 Email: inf@nsp.ie www.nsp.ie Imprving Surveillance and Mnitring f Self-harm in Irish Prisns Prject Scpe Dcument 8 th June
More informationObesity/Morbid Obesity/BMI
Obesity/mrbid besity/bdy mass index (adult) Obesity/Mrbid Obesity/BMI Definitins and backgrund Diagnsis cde assignment is based n the prvider s clinical judgment and crrespnding medical recrd dcumentatin
More informationMEASURE #10: PLAN OF CARE FOR MIGRAINE OR CERVICOGENIC HEADACHE DEVELOPED OR REVIEWED Headache
MEASURE #10: PLAN OF CARE FOR MIGRAINE OR CERVICOGENIC HEADACHE DEVELOPED OR REVIEWED Headache Measure Descriptin All patients diagnsed with migraine headache r cervicgenic headache wh had a headache management
More informationThe policy was formulated through consultation between members of staff, governors, parents and pupils.
VALENCE PRIMARY SCHOOL Fd and Drink Plicy INTRODUCTION Valence Primary Schl is dedicated t prmting healthy lifestyles and prviding an envirnment that prmtes healthy eating and drinking, enabling pupils
More informationModule 6: Goal Setting
Mdule 6: Gal Setting Objectives T understand the cncept f gal setting in Brief CBT T acquire skills t set feasible and apprpriate gals in Brief CBT What is gal setting, and why is it imprtant t set gals
More informationA Phase I Study of CEP-701 in Patients with Refractory Neuroblastoma NANT (01-03) A New Approaches to Neuroblastoma Therapy (NANT) treatment protocol.
SAMPLE INFORMED CONSENT A Phase I Study f CEP-701 in Patients with Refractry Neurblastma NANT (01-03) A New Appraches t Neurblastma Therapy (NANT) treatment prtcl. The wrd yu used thrughut this dcument
More information23/11/2015. Introduction & Aims. Methods. Methods. Survey response. Patient Survey (baseline)
Intrductin & Aims Drug and Alchl Cnsultatin Liaisn (AOD CL) services aim t imprve identificatin and treatment f patients with AOD mrbidity. The csts and cnsequences f targeting AOD patients presenting
More informationBRCA1 and BRCA2 Mutations
BRCA1 and BRCA2 Mutatins ROBERT LEVITT, MD JESSICA BERGER-WEISS, MD ADRIENNE POTTS, MD HARTAJ POWELL, MD, MPH COURTNEY LEVENSON, MD LAUREN BURNS, MSN, RN, WHNP OBGYNCWC.COM v Cancer is a cmplex disease
More informationCONSENT FOR KYBELLA INJECTABLE FAT REDUCTION
CONSENT FOR KYBELLA INJECTABLE FAT REDUCTION INSTRUCTIONS This is an infrmed cnsent dcument which has been prepared t help yur Dctr infrm yu cncerning fat reductin with an injectable medicatin, its risks,
More informationContinuous Quality Improvement: Treatment Record Reviews. Third Thursday Provider Call (August 20, 2015) Wendy Bowlin, QM Administrator
Cntinuus Quality Imprvement: Treatment Recrd Reviews Third Thursday Prvider Call (August 20, 2015) Wendy Bwlin, QM Administratr Gals f the Presentatin Review the findings f Treatment Recrd Review results
More informationIrritable Bowel Syndrome
Irritable Bwel Syndrme Questins & Answers GLASGOW COLORECTAL CENTRE Rss Hall Hspital 221 Crkstn Rad Glasgw G52 3NQ e-mail: inf@clrectalcentre.c.uk Ph: Main hspital switchbard - 0141 810 3151 Ph. General
More informationDiabetes Canada Pre-Budget Consultation Submission. Standing Committee on Finance and Economic Affairs. Government of Ontario.
Diabetes Canada 2018 Pre-Budget Cnsultatin Submissin Standing Cmmittee n Finance and Ecnmic Affairs Gvernment f Ontari January 17, 2018 1 Executive Summary Tday, abut 4.4 millin Ontarians, r 29 per cent
More informationFTD RESEARCH: The Value of Studies and Opportunities for Involvement
FTD RESEARCH: The Value f Studies and Opprtunities fr Invlvement Sarah Lawrence, MS Research Prgram Manager Ann Fishman, MBA Sr. Research Crdinatr Weiyi Mu, ScM Genetic Cunselr Suzanne Dana Spuse/Caregiver
More informationApproaches to the Care and Support of Individuals with Dementia
Unit 14: Persn-centred Appraches t the Care and Supprt f Individuals with Dementia Unit reference number: H/601/2879 Level: 2 Unit type: Optinal Credit value: 2 Guided learning hurs: 17 Unit summary Understanding
More informationUNIT 6. DEVELOPING THREAT/HAZARD-SPECIFIC ANNEXES
UNIT 6. DEVELOPING THREAT/HAZARD-SPECIFIC ANNEXES This page intentinally left blank. UNIT INTRODUCTION Visual 6.1 This unit presents infrmatin n annexes that shuld be included in a schl emergency peratins
More informationLEVEL OF CARE GUIDELINES: INTENSIVE BEHAVIORAL THERAPY/APPLIED BEHAVIOR ANALYSIS FOR AUTISM SPECTRUM DISORDER HAWAII MEDICAID QUEST
OPTUM LEVEL OF CARE GUIDELINES: INTENSIVE BEHAVIORAL THERAPY / APPLIED BEHAVIOR ANALYSIS FOR AUTISM SPECTRUM DISORDER HAWAII MEDICAID QUEST LEVEL OF CARE GUIDELINES: INTENSIVE BEHAVIORAL THERAPY/APPLIED
More informationPackage leaflet: Information for the user. Fragmin Graduated Syringe 10,000 IU/ml Solution for Injection dalteparin sodium
Package leaflet: Infrmatin fr the user Fragmin Graduated Syringe 10,000 IU/ml Slutin fr Injectin dalteparin sdium Read all f this leaflet carefully befre yu start using this medicine because it cntains
More informationTOP TIPS Lung Cancer Update Dr Andrew Wight Consultant respiratory Physician - WUTH
Tpic Circulatin list In case f query please cntact Executive Summary TOP TIPS Lung Cancer Update Dr Andrew Wight Cnsultant respiratry Physician - WUTH All Wirral GP s JaneFletcher2@nhs.net Dear Clleagues,
More informationDiabetes: HbA1c Poor Control (NQF 0059)
Diabetes: HbA1c Pr Cntrl (NQF 0059) EMeasure Name Diabetes: HbA1c Pr Cntrl EMeasure Id Pending Versin Number 1 Set Id Pending Available Date N infrmatin Measurement January 1, 20xx thrugh Perid December
More informationTreatment of Achalasia. Dr. Javad Mikaeli Professor of medicine Digestive Disease Research Center Tehran University of medical sciences
Treatment f Achalasia Dr. Javad Mikaeli Prfessr f medicine Digestive Disease Research Center Tehran University f medical sciences Treatment f Achalasia There is n cure fr the disease Treatment is fcused
More informationMedication Assisted Treatment for Opioid Use Disorder in Rural Colorado
Medicatin Assisted Treatment fr Opiid Use Disrder in Rural Clrad Why is piid use disrder getting s much attentin? Opiid Use Disrder (OUD) has seen an epidemic rise in the United States ver the past decade.
More informationEDPS 475: Instructional Objectives for Midterm Exam Behaviorism
EDPS 475: Instructinal Objectives fr Midterm Exam Behavirism 1. Given a nvel example t chse frm, identify the characteristics f classical cnditining. General mdel: Stimulus (S) elicits >Respnse (R) Based
More informationICT4LIFE. Final Conference. ICT4Life field work - tailored solutions in diverse regional context Ariane Girault, E-Seniors Association
ICT4LIFE Final Cnference ICT4Life field wrk - tailred slutins in diverse reginal cntext Ariane Girault, E-Senirs Assciatin 10/22/2018 1 Why a field wrk with users in a research prject? The bjectives f
More informationFDA Dietary Supplement cgmp
FDA Dietary Supplement cgmp FEBRUARY 2009 OVERVIEW Summary The Fd and Drug Administratin (FDA) has issued a final rule regarding current gd manufacturing practices (cgmp) fr dietary supplements that establishes
More informationMy Symptoms and Medical History for Adult Chronic Immune Thrombocytopenia (ITP)
My Symptms and Medical Histry fr Adult Chrnic Immune Thrmbcytpenia (ITP) Call t talk t a registered nurse 1-855-7Nplate (1-855-767-5283), Mnday Friday, 9:00 AM 9:00 PM ET Indicatin Nplate is a man-made
More informationYou may have a higher risk of bleeding if you take warfarin sodium tablets and:
MEDICATION GUIDE Warfarin (WAR-far-in) Sdium (SO-dee-um) Tablets USP The 7.5 mg tablets cntain FD&C Yellw N. 5 (tartrazine), which may cause allergic-type reactins (including brnchial asthma) in certain
More informationFood information to consumers - Commission proposal - COM (2008) 40 final 2008/0028 (COD) The European Heart Network s position in a nutshell
Fd infrmatin t cnsumers - Cmmissin prpsal - COM (2008) 40 final 2008/0028 (COD) The Eurpean Heart Netwrk s psitin in a nutshell Summary On 30 January 2008 the Eurpean Cmmissin published its prpsal fr a
More informationBedfordshire and Hertfordshire DRAFT Priorities forum statement Number: Subject: Prostatism Date of decision: January 2010 Date of review:
Bedfrdshire and Hertfrdshire DRAFT Pririties frum statement Number: Subject: Prstatism Date f decisin: January 2010 Date f review: Referral criteria Mst men with lwer urinary tract symptms due t benign
More informationVaccine Information Statement: LIVE INTRANASAL INFLUENZA VACCINE
Vaccine Infrmatin Statement: LIVE INTRANASAL INFLUENZA VACCINE Many Vaccine Infrmatin Statements are available in Spanish and ther languages. See www.immunize.rg/vis. Hjas de Infrmacián Sbre Vacunas están
More informationTASKFORCE REPORT AIMS TO BOOST CANCER SURVIVAL AND TRANSFORM PATIENT EXPERIENCE
Sunday 19 July, 2015 TASKFORCE REPORT AIMS TO BOOST CANCER SURVIVAL AND TRANSFORM PATIENT EXPERIENCE SIX STRATEGIC pririties have tday (Sunday) been recmmended by the Independent Cancer Taskfrce t help
More informationINTERIM REPORT JANUARY SEPTEMBER 2017
INTERIM REPORT JANUARY SEPTEMBER 2017 TELEPHONE CONFERENCE NO ONE SHOULD HAVE TO DIE WAITING FOR A NEW ORGAN Octber 27, 2017 MAGNUS NILSSON, CEO CHRISTOFFER ROSENBLAD, CFO NASDAQ OMX Stckhlm (mid cap):
More informationΥποτροπιάζουσες Περικαρδίτιδες: Τι νεότερο; Γεώργιος Λάζαρος Επιμελητής Α Α Πανεπιστημιακή Καρδιολογική Κλινική Ιπποκράτειο Γ.Ν.
Υποτροπιάζουσες Περικαρδίτιδες: Τι νεότερο; Γεώργιος Λάζαρος Επιμελητής Α Α Πανεπιστημιακή Καρδιολογική Κλινική Ιπποκράτειο Γ.Ν. Αθηνών Recurrent pericarditis after an initial episde f pericarditis ranges
More informationVaccine Information Statement: PNEUMOCOCCAL CONJUGATE VACCINE
Vaccine Infrmatin Statement: PNEUMOCOCCAL CONJUGATE VACCINE Many Vaccine Infrmatin Statements are available in Spanish and ther languages. See www.immunize.rg/vis. Hjas de Infrmacián Sbre Vacunas están
More informationSmoking Cessation Improvement in SFHN Primary Care,
Smking Cessatin Imprvement in SFHN Primary Care, 2015-16 David Silven, PhD, Supervising Psychlgist, SFHN Primary Care Behaviral Health Ellen Chen, MD, Directr f Quality, SFHN Primary Care Why smking assessment
More informationThe effects of a two-school. school-year. back education program. in elementary schoolchildren
IEA Maastricht - 12 July 2006 The effects f a tw-schl schl-year multi-factrial back educatin prgram in elementary schlchildren Drs Elisabeth Geldhf Prf Dr D De Clercq Prf Dr I De Burdeaudhuij Prf Dr G
More informationNational Programme on Technology Enhanced Learning (Phase II)
Lecture 22: Dialectical and Dialgic Theries f Relatinal Cmmunicatin The previus lecture discussed sme theries that explain the rle f cmmunicatin in the frmatin f interpersnal relatinships. This lecture
More informationA pre-conference should include the following: an introduction, a discussion based on the review of lesson materials, and a summary of next steps.
NAU Mdel Observatin Prtcl The mdel prtcl was develped with supprt and expertise frm the Natinal Institute fr Excellence in Teaching (NIET) and is based in great part n NIET s extensive experience cnducting
More informationTrust Protocol for the prevention and treatment of Fat Malabsorption in Adults with Cystic Fibrosis.
Trust Prtcl fr the preventin and treatment f Fat Malabsrptin in Adults with Cystic Fibrsis. A Clinical Plicy Nrflk and Nrwich University Hspital Fr Use in: Fundatin Trust Cystic Fibrsis (CF) team including
More informationCompleting the NPA online Patient Safety Incident Report form: 2016
Cmpleting the NPA nline Patient Safety Incident Reprt frm: 2016 The infrmatin cntained within this dcument is in line with the current Data Prtectin Act (DPA) requirements. This infrmatin may be subject
More informationEXPLORING THE PROCESS OF ASSESSMENT AND OTHER RELATED CONCEPTS
1 SECTION 1 INTRODUCTION: EXPLORING THE PROCESS OF ASSESSMENT AND OTHER RELATED CONCEPTS The Nature Of Assessment The Definitin Of Assessment The Difference Between Testing, Measurement And Evaluatin Characteristics
More informationInfluenza (Flu) Fact Sheet
Influenza (Flu) Fact Sheet What is the flu? The flu is a cntagius respiratry illness caused by influenza viruses. It can cause mild t severe illness, and at times can lead t death. Sme peple, such as lder
More informationHSC 106 Personal Health Plan for Learning Activities & Assessment linked to Michigan Teacher Preparation Standards
HSC 106 Persnal Health Plan fr Learning Activities & Assessment linked t Michigan Teacher Preparatin Standards Standard 1 Cmpetency 1.1 Understand basic health cntent as it relates t schl health educatin.
More informationHead and neck cancers are often treated with radiotherapy. Radiotherapy can lead to faster rates of tooth decay and poor healing in the mouth.
DENTAL EXTRACTION This infrmatin aims t help yu understand the peratin, what is invlved and sme cmmn cmplicatins that may ccur. It may help answer sme f yur questins and help yu think f ther questins that
More informationPET FORM Planning and Evaluation Tracking ( Assessment Period)
Divisin f: Behaviral Studies PET FORM Planning and Evaluatin Tracking (2010 2011 Assessment Perid) Persn Respnsible fr this Divisin: Jerry Mller Department f: Behaviral Sciences Persn Respnsible fr this
More informationVITAPRO. Detoxification properties of Apple pectin formulation, PROPECTIN. CENTRE D ETUDE ET DE VALORISATION DES ALGUES FINAL REPORT.
CENTRE D ETUDE & DE VALORISATION DES ALGUES 2400 Detxificatin prperties f Apple pectin frmulatin, PROPECTIN. VITAPRO FINAL REPORT PrPectin July 2015 CENTRE D ETUDE ET DE VALORISATION DES ALGUES PRESQU
More informationWhat You Need to Know About ZIKA VIRUS
What Yu Need t Knw Abut ZIKA VIRUS Refugee and Immigrant Health Seminar Tuesday, Nvember 1, 2016 Malaya Fletcher, MPH Glbal Migratin & Mnitring Crdinatr PDPH Divisin f Disease Cntrl 1 Backgrund n Zika
More informationPain Management Learning Plan
Pain Management Learning Plan Overriding Gal T imprve the quality f patient care available fr patients living with chrnic pain. Learning Outcmes By the end f the implementatin, participants will be able
More informationTop 10 Causes of Disability
Tp 10 Causes f Disability Disability can happen t anyne, f any age. Thugh sme may be the result f accidents r injuries that are unavidable, many disabilities are the result f diseases and health cnditins
More informationPatterns of Cholesterol Distribution in the Participants of a Screening Project
Patterns f Chlesterl Distributin in the Participants f a Screening Prject Abdul Hamid Shaikh, S With guidelines similar t thse recmmended by the Natinal Chlesterl Educatin Prgram (NCEP), 3,3 individuals
More informationSolid Organ Transplant Benefits to Change for Texas Medicaid
Slid Organ Transplant Benefits t Change fr Texas Medicaid Infrmatin psted February 13, 2015 Nte: All new and updated prcedure cdes and their assciated reimbursement rates are prpsed benefits pending a
More informationInterpretation. Historical enquiry religious diversity
Name: Year 8 Histry Prject 3: D The Cmmnwealth Games Still Matter In The 21 st Century? Mdule: Date Set: Deadline: Descriptin f the task: The prject is split int three separate parts: The prject is split
More informationState Health Improvement Plan Choosing Priorities, Creating a Plan. DHHS DPH - SHIP Priorities (Sept2016) 1
State Health Imprvement Plan 2017-2021 Chsing Pririties, Creating a Plan DHHS DPH - SHIP Pririties (Sept2016) 1 Creating a Plan: 2017-2021 SHIP Welcme! Wh s here? What is the State Health Imprvement Plan
More informationEVALUATION OF POVERTY AND STIGMA SESSIONS
Questin 1 As a result f participating in this sessin, my awareness f pverty has: Numbers lt 43 37 6 Ttal 86 lt Qutes / Cmments Already wrk clsely with emplyability pipeline and welfare rights Very infrmative
More informationPrevention Checklist for Men
Page 1 f 5 Preventin Checklist fr Men A lt f prgress has been made in cancer research, but we still dn t understand exactly what causes mst cancers. We d knw that many factrs put us at higher risk fr different
More informationUniversity College Hospital. Pump school Starting on an insulin pump. Children and Young People s Diabetes Service
University Cllege Hspital Pump schl Starting n an insulin pump Children and Yung Peple s Diabetes Service 2 If yu wuld like this dcument in anther language r frmat, r require the services f an interpreter,
More informationTick fever is a cattle disease caused by any one of the following blood parasites:
Tick fever Tick fever is a cattle disease caused by any ne f the fllwing bld parasites: Babesia bvis Babesia bigemina Anaplasma marginale These parasites are all transmitted by the cattle tick (Bphilus
More informationAccess to Heme Treatment in Canada - Survey 2018
Access t Heme Treatment in Canada - Survey 2018 The Canadian Assciatin fr Prphyria/Assciatin Canadienne de Prphyrie (CAP/ACP) asserts that patients with acute prphyria shuld have access t Hemin treatment,
More informationChronic Fatigue Syndrome
Chrnic Fatigue Syndrme (Als knwn as Myalgic encephalmyelitis/encephalmyelpathy) What is CFS/ME? CFS/ME cmprises a range f symptms that include fatigue, malaise, headaches, sleep disturbances, difficulties
More information