2018 Research Recap. Moving the Needle Pycnogenol Update Robuvit Update Advocate Insight

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1 REPORT ISSUE LOOK, FEEL AND LIVE BETTER 2018 Research Recap Moving the Needle Pycnogenol Update Robuvit Update Sp ec ia le di tio n Advocate Insight

2 feature story 2018 Research Recap To say it s been a banner year in research is an understatement! Here are some of the most significant new research studies of Update Moving the Needle 40+ Years of Research Pycnogenol Helps with Travel Health Recent published research shows that Pycnogenol is beneficial for travel health, with proven benefits for reducing lower leg swelling and jet lag symptoms often associated with long-haul flights. Researchers found that participants who supplemented with Pycnogenol resulted in greater reduction of ankle circumference and lower leg swelling and also reported less leg pain after flights. The extract also helped alleviate jet lag symptoms like fatigue, visual impairment and inability to sleep. This study builds on previous research on Pycnogenol 's benefits for reducing venous conditions and managing jet lag symptoms. Travel Health / Ankle Circumference 160+ Clinical Studies Ankle Circumference (Moderate Risk Subjects) Control Group 420+ Scientific Publications Stockings Group Pycnogenol Group ,000+ Product formulations worldwide in 80 Countries ,000+ Subjects tested Ankle Circumference (cm) 150 mg/day N=295 p<0.05 vs both controls Belcaro, G., et al. (2018). Minerva Cardioangiol 66(2): Pycnogenol Effective in Improving MCI Symptoms New published research shows the cognitive health benefits of natural super antioxidant Pycnogenol for reducing symptoms associated with Mild Cognitive Impairment (MCI) a potential risk factor for early onset dementia and other degenerative cognitive conditions. Findings show the extract significantly enhances the ability to remember friends and family, improves ability to remember where things are and the ability to manage finances. This study builds upon previous research supporting the benefits of Pycnogenol for cognitive health improvement including brain health functions like memory, decision-making and focus. Cognitive Function / Moderate Cognitive Impairement MMSE Score at 8 weeks (Minimal Mental Stage Examination) Improvement IQCODE Score (Informant Questionnaire on Cognitive Decline in the Elderly) Travel Health / Jet-Lag Jet-Lag Score / Long-Haul Fligths (Moderate Risk Subjects) Control Group Hosoi, M., et al. (2018). J Neurosurg Sci 62(3): % Pycnogenol Group % Stockings Group Jet Lag 150 mg/day N=295 p<0.05 vs both controls Belcaro, G., et al. (2018). Minerva Cardioangiol 66(2):

3 feature story Intestinal Health / Irritable Bowel Syndrome (IBS) Pycnogenol Improves IBS Irritable bowel syndrome (IBS) affects the large intestine. Signs and symptoms include cramping, abdominal pain, bloating, gas, and diarrhea or constipation. In a recent study, Pycnogenol was shown to improve IBS symptoms by 75% and performed better than Buscopan and Antispamsmina Colica Forte. In addition, Pycnogenol helped decrease the need for rescue medication. Pycnogenol Reduces Post thrombotic Syndrome & Recurrent Thrombosis Risk Pycnogenol may reduce the incidence of post-thrombotic syndrome (PTS) and recurrent thrombosis, a potentially lifethreatening condition that may occur as a long-term complication of deep vein thrombosis (DVT), caused by a blood clot forming in the lower leg. More than one third of people who have DVT then develop PTS, and symptoms include redness, swelling, ulcers, and chronic leg pain. The new peer-reviewed study followed 815 patients over the course of six years. Daily supplementation with Pycnogenol was shown to perform better than aspirin, ticlopidine and sulodexide in the treatment of DVT and PTS symptoms. Recurrent abdominal pain Altered bowel movement and distenstion -4 Meteorism -4% -1-41% -42% Cramps All symptoms -13% -21% -27% -38% -41% -41% -46% -48% -5-54% -6-59% -6-69% -7-8 Buscopan -75% Pycnogenol Antispasmina colica forte + decreased need for rescue medication Belcaro, G., et al. (2018). Panminerva Med 60(2): Venous Health / Post-thrombotic syndrome and Deep Vein Thrombosis 35.0 Pycnogenol in prevention of post-thrombotic syndrome and DVT at 6 years Controls Aspirin Pycnogenol years Occurrenceof recurrent DVT 200 mg/day N=424 Pycnogenol Improves BPH Urinary Symptoms Benign Prostate Hypertrophy (BPH) is a common benign tumor that develops in men and is bothersome in elderly patients. The prevalence of lower urinary tract symptoms in the general population increases with aging. In this new study, Pycnogenol was shown to improve multiple urinary BPH symptoms such as frequency with statistically significant results after 8 weeks. Abdominal pain at pressure 6 years Incidence of PTS % p<0.05 R-DVT+PTS Belcaro, G., et al. (2018). Minerva Cardioangiol 66(3): Prostate / Benign Prostate Hypertrophy Improvement % of urinary BPH symptoms after 8 weeks Emptying Frequency Intermittency -6% -5% -1-12% -15% -6% -37% -42% Pycnogenol Controls -18% -24% -35% Nocturia -6% -17% -24% Straining -19% -25% -45% Weak flow -14% -4 Urgency Dudasteride + finasteride Ledda, A., et al. (2018). Minerva Med 109(4):

4 feature story Update It s been a busy summer for Horphag s new proprietary French oak wood extract Robuvit with several new research studies published on the extract s health properties. Robuvit is a caffeine-free natural energizer shown to support detoxification and liver function, boost energy in those with fatigue and chronic fatigue syndrome and support sports performance. Innovative product formulations can be found at Robuvit Shown to Reduce Symptoms of Workplace Burnout New research shows daily supplementation with Robuvit French oak wood extract can help curb workplace burnout symptoms, including fatigue, low tolerance levels and lack of job satisfaction. Robuvit was shown to help individuals with high-stress jobs feel better at work because its antioxidant properties cut down on oxidative stress which can lead to fatigue. This study builds upon a growing catalogue of research on Robuvit for its natural energy and detoxification benefits % improvement of Burnout scoring in 4 weeks in surgery students 29% Robuvit / Burnout Syndrome in Young Surgeons 1 Effective dealing with patients problems Robuvit Controls 68% Feeling of a positive influence on other people 57% -6% -4% Happy working with patients 55% 5% Satisfied for being a doctor Hosoi M., et al. To be submitted N= mg/day p< 0.05 Robuvit Shown to Improve Recovery from the Flu Recent research demonstrates Robuvit provides flu recovery support. With few flu convalescence products on the market, this research provides the first evidence that Robuvit s natural antioxidant properties help to support the body s defenses after the immune system is weakened from fighting the virus. Supplementation with Robuvit was shown to help patients recover faster from the flu by increasing postflu strength, boosting recovery after exerting effort, enhancing sleep quality and more % decrease of main signs/symptoms of convalescence in 3 weeks -6-85% Weakness [0-5] Robuvit / Post-flu Convalescence -48% -64% Recovery after effort [0-5] Alterations in attention [0-5] -59% -82% -83% -82% Sleep patterns [0-3] Alterations in working and concentration capacity [0-5] Controls Robuvit Ippolito, E., et al. (2018). J Sports Med Phys Fitness 58(5): N= mg/day p<0.05

5 quotes What the Advocates are Saying It s hard to believe I have been educating my radio listeners for more than two decades about Pycnogenol. From skin to heart health, this clinically proven nutraceutical from French maritime pine bark extract is ideal for addressing vascular health and wellness. With my busy travel schedule, Pycnogenol is the perfect solution for reducing jet lag and improving leg circulation when on long flights. It continues to be one of the most successful stories in branding history for a single, natural supplement and for its impact on human health. -Danielle Lin, CN Syndicated Radio host The Danielle Lin Show The Art of Living and Science of Life I m a strong advocate for Pycnogenol and regularly recommend it to most patients because of its versatility as a healthy aging ingredient. Pycnogenol is important for aging and looking and feeling younger, longer because it works directly with the collagen and elastin in your body which prevents us from having wrinkles, protects our blood vessels and supports our muscles and joints. If I m stranded on a desert island and could only choose a handful of supplements, Pycnogenol would definitely be one of them. -Dr. Fred Pescatore, best-selling author and renowned natural health physician If only trees could talk The sheer amount of science on Pycnogenol more than 25 years ago led me to discover and start researching this supplement myself. The more research I did on it, the more it made sense to me how this ingredient works to not only prevent illness but to modify common disorders such as varicose veins, hypertension, and elevated cholesterol and be an important building block of wellness. Pycnogenol is one of my go to recommendations for my patients that are looking to enhance their level of wellness with one product. -Dr. Steven Lamm, Medical Director of NYU Langone Center for Men s Health

6 welcome featuring... I 2018 RESEARCH RECAP recently sat down with our science team and we collectively counted more than fifteen Pycnogenol publications on Medline thus far in 2018 a pivotal moment for all of us! As our partners and colleagues, you understand how deeply rooted our company is in research and we are proud of each study and article that educates and elevates Pycnogenol as a gold standard ingredient, positively impacting how well people live every day. We are grateful to be the guides that navigate this extraordinary ingredient as it moves the needle in groundbreaking scientific discoveries. MOVING THE NEEDLE PYCNOGENOL UPDATE ROBUVIT UPDATE ADVOCATE INSIGHT Enjoy this special science edition of the Report! Best Regards, follow us on Pycnogenol, French maritime pine bark extract, is a registered trademark Victor Ferrari Chief Executive Officer Horphag Research of Horphag Research Ltd and is protected by U.S. patents #5,720,956 and #6,372,266 and other international patents.