Pelvic Pain Tool Box NO FINANCIAL DISCLOSURES OBJECTIVES. Chronic Pelvic Pain. Treating Chronic Pelvic Pain 6/4/2018

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Pelvic Pain Tool Box Shanti Mohling, MD, FACOG Director of Gynecology Associate Director Fellowship in Minimally Invasive Gynecologic Surgery University of Tennessee College of Medicine, Chattanooga

1 Pelvic Pain Tool Box Shanti Mohling, MD, FACOG Director of Gynecology Associate Director Fellowship in Minimally Invasive Gynecologic Surgery University of Tennessee College of Medicine, Chattanooga NO FINANCIAL DISCLOSURES OBJECTIVES Define Chronic Pelvic Pain (CPP) Discuss Evidence based approaches to medical management Focus on 3 common pelvic pain conditions Chronic Pelvic Pain From UpToDate: Chronic pelvic pain is defined as pain that occurs below the umbilicus that lasts for at least 6 months. It may or may not be associated with menstrual periods. Also: It may be a symptom of another disease or may be a condition of its own. Treating Chronic Pelvic Pain Pelvic Pain as the disease, or Pelvic pain as a multifactorial entity 70% of cases of CPP are estimated to be non-gynecologic Reminding ourselves to remain compassionate and creative Howard FM. Chronic pelvic pain, Obstet Gynecol. 2003;101:

2 Characteristics of the Chronic Pain Syndrome Duration of 6 months or more Incomplete relief by previous treatments Pain out of proportion to tissue damage Loss of physical function Vegetative signs of depression Altered family dynamics Steege, Metzger, Levy. Chronic Pelvic Pain: An Integrated Approach, W.B. Saunders Co. 1998, p.9. Central Sensitization Chronic pain can result in Central Sensitization Maintains chronic pain pathways between peripheral body and CNS Management tailored to multimodal treatments and centrally acting medications: Treat both somatic and visceral body Adjunctive medications and modalities Howard, FM, Butrick, CW. Discordant urination and defecation as symptoms of pelvic floor dysfunction. Pelvic Pain: Diagnosis & Management, Lippincott Williams & Wilkins. Somato-visceral convergence Centralization of Pain Metabolic and neuropathic changes in the spinal cord, resulting from prolonged noxious stimuli to the spinal cord, that can result in persistent pain that is neurologically maintained even when the original insult has been eradicated. Howard, FM, Butrick, CW. Discordant urination and defecation as symptoms of pelvic floor dysfunction. Pelvic Pain: Diagnosis & Management, Lippincott Williams & Wilkins. Chronic Pelvic Pain Breakdown Gynecologic: Endometriosis, cysts, adenomyosis, vulvodynia, pudendal neuralgia, prolapse, adhesions... Urologic: Bladder Pain Syndrome/Interstitial cystitis GI: IBS, chronic constipation Myofascial pain: Abdominal wall trigger points, pelvic floor myalgia Psychiatric: PTSD, history of abuse Neurologic: eg. Pudendal Neuralgia Pelvic pain that does not respond to combined oral contraceptives: think endometriosis and consider referral OCP for pain Persistent pain Improvement High risk endometriosis Low risk endometriosis 2

3 Endometriosis 3

4 Cochrane Review: Non-surgical management of chronic pelvic pain Chronic pelvic pain is complex Up to 55% of women with CPP have no findings on laparoscopy (Howard, 1993) Up to 85% have dysfunction of musculoskeletal system CPP carries a significant mental, social and physical burden for the sufferer as well as the healthcare system Non-surgical interventions for the management of chronic pelvic pain. YC Cheong, Gsmotra, ACCWilliams, Cochraine Library, March 2014 Non-surgical interventions 13 RCT studies were included DMPA compared with placebo Treatment with DMPA improved pain >/= 50% reduction VAS pain scores DMPA associated with weight gain/bloating YC Cheong, Gsmotra, ACCWilliams, Non-surgical interventions for the management of chronic pelvic pain. Cochraine Library, March 2014 Gabapentin vs Amitriptyline Primary outcome: Pain VAS pain score favored gabapentin compared with amitriptyline at 24 months (95% CI -2.6 to -0.94) (Sator-Katzenschlager 2005) Authors reported no significant difference in rate of side effects Epidemiology of Endometriosis 6-22% of women at time of Tubal Ligation 15-80% of women with CPP 21-65% of women with infertility 7-10% of population YC Cheong, Gsmotra, ACCWilliams, Non-surgical interventions for the management of chronic pelvic pain. Cochraine Library, March 2014 Yeung PP Jr, Shwayder J, Pasic RP. Laparoscopic management of endometriosis: comprehensive review of best evidence. J Minim Invasive Gynecol. 2009;16(3):269. Medical management of Endometriosis EMPIRIC use of a gonadotropin-receptor hormone analogue (GnRH agonist) has been tested in a single randomized controlled trial (by Ling) in 100 women with clinically suspected endometriosis. After 12 weeks of therapy with Lupron 3.75 mg/mo, women had decreased dysmenorrhea and pelvic pain. Medical management of Endometriosis HOWEVER, GnRH agonist incorrectly predicted the presence or absence of endometriosis in 32% of patients. Yeung PP Jr, Shwayder J, Pasic RP. Laparoscopic management of endometriosis: comprehensive review of best evidence. J Minim Invasive Gynecol. 2009;16(3):269. Yeung PP Jr, Shwayder J, Pasic RP. Laparoscopic management of endometriosis: comprehensive review of best evidence. J Minim Invasive Gynecol. 2009;16(3):269. 4

Role of stress Studies on endometriosis have shown us that endometriosis is associated with increased levels of stress (actual increased levels of stress hormones) In animal model, the endometriotic

5 Role of stress Studies on endometriosis have shown us that endometriosis is associated with increased levels of stress (actual increased levels of stress hormones) In animal model, the endometriotic lesions actually seem to induce increased levels of stress. Stress management: counseling, acupuncture, massage, medications Lifestyle modifications: decreasing caffeine and alcohol Endometriosis alters brain electrophysiology: increased pain sensitization and anxiety in mice Acupuncture for pain in Endometriosis Cochrane review 24 studies reviewed: one met all criteria based on the Guideline for Clinical Research on New Chinese Medicine Auricular acupuncture significantly reduced pain in cases of severe dysmenorrhea Medical Management Does using a levonorgestrel IUD after conservative surgery for endometriosis improve pain? YES Randomized trial. Vercellini et al. 40 patients with stage III-IV endometriosis randomized to either LNG-IUS or expectant management after laparoscopic treatment. Significant reduction in pain (10% vs 45%). Need to treat 3 patients for 1 to benefit. Yeung PP Jr, Shwayder J, Pasic RP, Laparoscopic management of endometriosis: comprehensive review of best evidence. J Minim Invasive Gynecol. 2009;16(3):269. Hormonal suppression Routinely a first-line treatment for pelvic pain and dysmenorrhea Goal is to induce amenorrhea, oligomenorrhea or to decrease dysmenorrhea OCP, Levonorgestrel IUD, Nexplanon, etc. Endometriosis post surgery Hormonal suppression (Progestin-only therapy may be superior) Consideration of GnRH agonist Gabapentin or Amitriptyline Manage depression if present Acupuncture treatments Stress reduction strategy Carey ET, Till SR, As-Sanie S, Pharmacological Management of Chronic Pelvic Pain in Women, Drugs (2017) 77:

Interstitial cystitis/ Bladder Pain Syndrome Chronic inflammatory condition of bladder Classic symptoms: urgency, frequency, nocturia, pelvic pain and dyspareunia Absence of objective evidence of

Anesthetic Bladder Challenge Instillation of numbing medication in the bladder (Bladder instillation) Cystoscopy with hydrodistention Usually done in the operating room Filling it to capacity and

6 Interstitial cystitis/ Bladder Pain Syndrome Chronic inflammatory condition of bladder Classic symptoms: urgency, frequency, nocturia, pelvic pain and dyspareunia Absence of objective evidence of another disease Characteristic cystoscopic findings: Decreased bladder capacity Glomerulations in 4 quadrants after hydrodistention Hunner s ulcers (pathognomonic) Curtain sign Diagnostic tests Anesthetic Bladder Challenge Instillation of numbing medication in the bladder (Bladder instillation) Cystoscopy with hydrodistention Usually done in the operating room Filling it to capacity and maintain for 2 minutes Observe changes while emptying Refill and observe for glomerulations IC/BPS: First-line treatment Dietary: Eliminate caffeine, sodas, chocolate, alcohol first Increase intake of water Tobacco cessation Physical therapy Medications for IC/BPS Amitriptyline 25 mg oral at bedtime Hydroxyzine 25 mg oral at bedtime Cimetidine 400 mg oral daily Bladder instillations can be done in clinic: Solumedrol Heparin Sodium bicarbonate Bupivacaine Myofascial Pain Syndrome Pelvic floor myalgias Prospective analysis: Up to 73% of women with self-reported pelvic pain demonstrated pelvic floor tenderness on exam Vaginismus Involuntary contraction of perineal and levator muscles Fitzgeral CM, et al. Pelvic floor muscle examination in female chronic pelvic pain. J Reprod Med. 2011;56(304):

Myofascial Pain Frequently missed source of pelvic pain Should always be evaluated before doing hysterectomy for pelvic pain Most common somatic cause of pain when diagnostic laparoscopy is negative

7 Myofascial Pain Frequently missed source of pelvic pain Should always be evaluated before doing hysterectomy for pelvic pain Most common somatic cause of pain when diagnostic laparoscopy is negative Myofascial pain often mis-labled as psychosomatic Can overlap with visceral pain (neural cross-talk ) Carnett s test With single digit pressure, examine patient s abdomen for specific areas of pain Have the patient raise her head enough to tighten the abdominal wall. If the pain lessens with this, one can assume the pain is deep to the abdominal wall If the pain intensifies with this manoeuver, one can assume the pain is within the abdominal wall Abdominal Wall Trigger Points Early work by John Slocumb (1983) documents relationship between trigger points of abdominal wall fascia and coexistence of recurrent visceral dysfunction Afferent nerve supply to abdominal wall overlaps at dorsal root with afferent and efferent visceral nerves Single digit pressure exam Trigger Points in fascia or scar tissue do not have classic referred pain zones Slocumb, JC, Neurological factors in chronic pelvic pain: Trigger points and the abdominal pelvic pain syndrome, Am J Obstet. Gynecol. 149: Trigger Points Travell and Simons characterize trigger points as: focus of hyperirritability on a muscle or its fascia that is symptomatic with respect to pain Refers a pattern of pain at rest or in motion that is specific for the muscle Palpation of trigger points often reproduces the sensation of pain Can closely mimic visceral disorders Travell JG, Simons DG, Myofascial Pain and Dysfunction. The Trigger Point Manual, Vol 1 & 2. Baltimore, Williams & Wilkins, Electron micrograph of TP Iliopsoas muscle Most powerful hip flexor Often a history of aerobics or stairstepping exercise Laparoscopic surgery may have preceded pain Can cause low back, lower abdominal and anterior hip pain 7

Iliopsoas trigger points Referred pain pattern for trigger points in External Oblique Trigger Point Injections

anesthetic solution Lidocaine, bupivacaine with or without epinephrine are traditionally used.

Ilioinguinal-Iliohypogastric Nerve Block Point of injection is 2 cm superior and medial to the ASIS A blunt needle

8 Iliopsoas trigger points Referred pain pattern for trigger points in External Oblique Trigger Point Injections Myofascial Trigger Points with specific referred pain patterns Matrix points are injected with 3-5 cc of anesthetic solution Lidocaine, bupivacaine with or without epinephrine are traditionally used. Needle the TP to identify exact point that mimics the pain. Withdraw for blood. Inject anesthetic. Ilioinguinal-Iliohypogastric Nerve Block Point of injection is 2 cm superior and medial to the ASIS A blunt needle tip is ideal. The needle is inserted through the skin and through the aponeurosis of the external and internal oblique muscles. Ultrasound guidance may be helpful 8

Vaginal Trigger Point Injections May need to be done in the operating room with IV sedation Some patients tolerate this in clinic Patients need to be responsive enough to direct

floor spasm but still used and highly effective in select patients Block acetylcholine release from presynaptic neurons Pelvic Floor Physical Therapy Therapists specially trained

9 Vaginal Trigger Point Injections May need to be done in the operating room with IV sedation Some patients tolerate this in clinic Patients need to be responsive enough to direct injections Use Pudendal Nerve kit needle and Iowa Trumpet or similar guide Vaginal approach TPIs Vaginal Botox Injections Botox injections may be used Not FDA approved for pelvic floor spasm but still used and highly effective in select patients Block acetylcholine release from presynaptic neurons Pelvic Floor Physical Therapy Therapists specially trained to work on the muscles of the pelvic floor including transvaginal and trans-rectal work Muscles of the pelvic floor can be treated in much the same way neck and back muscles are treated. 9

PT: Vaginal Biofeedback Connects to a unit that senses pressure. Patients learn to relax muscles with biofeedback Tool box: Modalities reviewed Judicious use of pain medications (avoiding opiates)?

Gabapentin) Antidepressant medications Physical therapy pelvic floor, massage and acupuncture Trigger point injections Non-surgical interventions for the management of chronic pelvic pain.

10 PT: Vaginal Biofeedback Connects to a unit that senses pressure. Patients learn to relax muscles with biofeedback Tool box: Modalities reviewed Judicious use of pain medications (avoiding opiates)? Hormonal therapy Anti-convulsants (eg. Gabapentin) Antidepressant medications Physical therapy pelvic floor, massage and acupuncture Trigger point injections Non-surgical interventions for the management of chronic pelvic pain. YC Cheong, Gsmotra, ACCWilliams, Cochraine Library, March 2014 REFERENCES 1. FM Howard, Chronic Pelvic Pain, Am College Ob & Gyn, March 2003, Vol. 101, No. 3, pp Steege, Metzger, Levy. Chronic Pelvic Pain: An Integrated Approach, W.B. Saunders Co. 1998, p Howard, FM, Butrick, CW. Discordant urination and defecation as symptoms of pelvic floor dysfunction. Pelvic Pain: Diagnosis & Management, Lippincott Williams & Wilkins. 4. YC Cheong, Gsmotra, ACCWilliams, Non-surgical interventions for the management of chronic pelvic pain. Cochraine Library, March Yeung PP Jr, Shwayder J, Pasic RP. Laparoscopic management of endometriosis: comprehensive review of best evidence. J Minim Invasive Gynecol. 2009;16(3): Li T, Maillapalli R, et al. Endometriosis alters brain electro-physiology, gene expression and increased pain sensitiztion, anxiety, and depression in female mice. Biol Reprod Feb 7. doi: /biolre/ioy Dongfang X, Yi S, Xuefang L, Ear Acupunctue Therapy for 37 Cases of Dysmenorrhea Due to Endometriosis. Journal of Trad Chin Med 22 (4): , Carey ET, Till SR, As-Sanie S, Pharmacological Management of Chronic Pelvic Pain in Women, Drugs (2017) 77: REFERENCES (Cont.) 9. Fitzgeral CM, et al. Pelvic floor muscle examination in female chronic pelvic pain. J Reprod Med. 2011;56(304): Slocumb, JC, Neurological factors in chronic pelvic pain: Trigger points and the abdominal pelvic pain syndrome, Am J Obstet. Gynecol. 149: Travell JG, Simons DG, Myofascial Pain and Dysfunction. The Trigger Point Manual, Vol 1 & 2. Baltimore, Williams & Wilkins, Vercellini P, Trespidi L, Colombo A, Vendola N, Marchini M, Crosignani PG. A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Fertil Steril. 1993;60(1): Jones CA, Harris MA, Nyberg L. Prevalence of interstitial Cystitis in the United States, Proc Am Urol. Ass J Urol. 1994; 151 (Suppl):423A. 14. Theoharides TC. Hydroxyzine in the treatment of interstitial cystitis. Urol Clin North Am 1994;21(1): Thank you 10

Chronic Pelvic Pain. Bridget Kamen, MD Obstetrics and Gynecology, Confluence Health. I have no disclosures

Chronic Pelvic Pain. Bridget Kamen, MD Obstetrics and Gynecology, Confluence Health. I have no disclosures Chronic Pelvic Pain Bridget Kamen, MD Obstetrics and Gynecology, Confluence Health I have no disclosures Objectives A little epidemiology Understand there are both gynecologic and non-gynecologic causes