Barbara G. Wells, PharmD, FASHP, FCCP, BCPP Dean and Professor School of Pharmacy, The University of Mississippi Oxford, Mississippi
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1 Barbara G. Wells, PharmD, FASHP, FCCP, BCPP Dean and Professor School of Pharmacy, The University of Mississippi Oxford, Mississippi Joseph T. DiPiro, PharmD, FCCP Panoz Professor of Pharmacy, College of Pharmacy University of Georgia Clinical Professor of Surgery Medical College of Georgia Augusta, Georgia Terry L. Schwinghammer, PharmD, FCCP, FASHP, BCPS Professor of Pharmaceutical Sciences School of Pharmacy, University of Pittsburgh Pittsburgh, Pennsylvania Cindy W. Hamilton, PharmD Principal, Hamilton House Virginia Beach, Virginia Clinical Instructor Virginia Commonwealth University School of Pharmacy Richmond, Virginia McGraw-Hill Medical Publishing Division New York Chicago San Francisco Lisbon London Madrid Mexico City Milan Seoul New Delhi San Juan Singapore Sydney Toronto
2 CONTENTS Preface ix Acknowledgments xi To the Reader.,..,. xiii BONE AND JOINT DISORDERS 1. Gout and Hyperuricemia 1 2. Osteoarthritis 7 3. Osteoporosis Rheumatoid Arthritis 25 CARDIOVASCULAR DISORDERS 5. Arrhythmias Cardiopulmonary Resuscitation Heart Failure 56 8 Hyperlipidemia Hypertension'' Ischemic Heart Disease Myocardial Infarction Shock Stroke Venous Thromboembolism 142 DERMATOLOGIC DISORDERS 15. Acne Psoriasis :". 163 ENDOCRINOLOGIC DISORDERS 17. Diabetes Mellitus Thyroid Disorders 184 GASTROINTESTINAL DISORDERS (Edited by Joseph T. DiPiro) 19. Cirrhosis and Portal Hypertension Constipation 204 V
3 21. Diarrhea Gastroesophageal Reflux Disease Hepatitis, Viral Inflammatory Bowel Disease Nausea and Vomiting Pancreatitis Peptic Ulcer Disease 268 GYNECOLOGIC AND OBSTETRIC DISORDERS 28. Contraception Hormone Replacement Therapy Pregnancy and Lactation 300 HEMATOLOGIC DISORDERS 31. Anemias Sickle Cell Anemia 317 INFECTIOUS DISEASES (Edited by Joseph T. DiPiro) 33. Antimicrobial Regimen Selection Central Nervous System Infections Endocarditis Fungal Infections, Invasive "r Gastrointestinal Infections HIV/AIDS Intra-Abdominal Infections: Respiratory Tract Infections, Lower Respiratory Tract Infections, Upper Sepsis and Septic Shock Sexually Transmitted Diseases Skin and Soft Tissue Infections Surgical Prophylaxis Tuberculosis Urinary Tract Infections and Prostatitis Vaccines, Toxoids, and Other Immunobiologics 492
4 NEUROLOGIC DISORDERS 49. Epilepsy Headache: Migraine and Cluster Pain Management Parkinson's Disease ; Status Epilepticus 560 NUTRITIONAL DISORDERS 54. Assessment and Nutrition Requirements Enteral Nutrition Obesity Parenteral Nutrition 593 ONCOLOGIC DISORDERS 58. Agents for Cancer Treatment Breast Cancer Colorectal Cancer Lung Cancer Lymphomas Prostate Cancer. 643 OPHTHALMIC DISORDERS 64. Glaucoma 649 PSYCHIATRIC DISORDERS (Edited by Barbara G. Wells) 65. Alzheimer's Disease Anxiety Disorders Bipolar Disorder Depressive Disorders Schizophrenia 718 i 70. Sleep Disorders Substance-Related Disorders 739 vii
5 RENAL DISORDERS 72. Acid-Base Disorders Dialysis Drug Dosing in Renal Insufficiency Electrolyte Homeostasis Renal Failure: Acute Renal Failure: Chronic 802 RESPIRATORY DISORDERS 78. Allergic Rhinitis Asthma Chronic Obstructive Lung Disease 839 UROLOGIC DISORDERS 81. Male Sexual ysfunction Benign Prostatic Hyperplasia Urinary Incontinence 861 APPENDICES (Edited by Barbara G. Wells) Appendix 1. Allergic and Pseudoallergic Drug Reactions 867 Appendix 2. Drug-Induced Hematologic Disorders 872 Appendix 3. Drug-Induced Liver Disease 875 Appendix 4. Drug-Induced Pulmonary Disorders 877 Appendix 5. Drug-Induced Skin Disorders 883 Appendix 6. Drug-Induced Renal Disease 888 Index 891 viii
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