UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication

Size: px
Start display at page:

Download "UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication"

Transcription

1 UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication Citation for published version (APA): Amri, R. (2015). Clinical issues in the surgical treatment of colon cancer General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 24 Dec 2017

2 Part III: Surgical Safety and Complications

3

4 Chapter 10: The impact of adhesions on operations and postoperative recovery in colon cancer surgery Ramzi Amri Hannah C. den Boon Liliana G. Bordeianou Patricia Sylla David L. Berger American Journal of Surgery. 2013;206(2):

5 Chapter 10 Abstract Background Many surgeons assume that adhesions encountered during surgery negatively influence surgical outcomes. This article attempts to assess the role adhesions have on outcomes of colon cancer surgery. Methods Records of 1071 consecutive patients operated for colonic adenocarcinoma ( ) were reviewed. Patients were assigned to 3 groups: no adhesions, any adhesions, or dense adhesions. Multivariate regression assessed the association between adhesions and the duration of surgery and stay as well as laparoscopic conversion and complication rates. Results Adhesions were encountered in 329 (30.7%) patients; 138 (12.8%) had dense adhesions. After correction for age and comorbidities, having adhesions was associated with longer surgeries (P<0.001), longer hospital stays (P=0.029), a borderline significantly higher conversion rate (P=0.058), and a delayed return of bowel function (P=0.037). Dense adhesions had stronger associations with surgical duration (P<0.001), stay duration (P<0.001), and conversion (P<0.001). Conclusions Abdominal adhesions independently put patients at risk for a longer and more complicated perioperative stay after colon cancer surgery. 138

6 Impact of adhesions on surgery and recovery T he consequences of intra-abdominal adhesions encountered when performing colorectal surgery are difficult to quantify. Adhesions are a common surgical finding and have been reported to develop after up to 90% of major abdominal surgeries. 1 Reports estimate that between 14% 1,2 and up to 40% 3 of all bowel obstructions are related to adhesions. The risk of developing a small bowel obstruction related to adhesions after undergoing an open colectomy has been estimated at 9% 4 in previous literature. Adhesions are possibly a source of various intraoperative complications. In addition, adhesiolysis may cause a longer operative time, 5 may contribute to laparoscopic conversions, 6 and may lead to a longer postoperative stay. 7, 8 The clinical magnitude of adhesions is poorly researched, 7 and earlier research focused on the long-term complications caused by the formation of adhesions. In contrast, little is known about the risks for patients who have abdominal adhesions while undergoing colorectal surgery or, in particular, colon cancer patients. Patients who have dense adhesions may be particularly affected. The aim of this study is to investigate the role of (dense) adhesions in causing perioperative complications. Methods Patients Electronic and paper records for all patients operated on for colon cancer at Massachusetts General Hospital between January 1, 2004, and December 31, 2011, were reviewed. Patients were assigned to three groups: The first of these is the control group, which was formed by all patients without any intraoperative findings of adhesions. The second group comprised all patients who were reported to have adhesions. The third group includes only cases in which operative reports described extensively dense adhesions. Although the latter is essentially formed by reported observations during surgery, this approach is the only way to isolate the most stringent intraoperative adhesions for the lack of a systematically used objective score to use as a selection criterion. Tumor attachments to other structures and any other forms of tumor adherence were not considered to be adhesions. The main outcome measures were the duration of the operation, the conversion rate, the duration of stay, and 30-day postoperative morbidity and mortality. Secondary outcome measures were reoperation and readmission. The population was controlled for differences in baseline characteristics including age, race, sex, body mass index, American Society of Anesthesiologists (ASA) classification, and Charlson comorbidity score

7 Chapter 10 We also verified for any differences in smoking habits and the prevalence of symptomatic inflammatory bowel disease. Multivariate regression models were used to correct for any of the potential confounders caused by differences in baseline characteristics. Statistical analysis Statistical significance was assessed using the chi-square (χ 2 ) test or the Mann-Whitney U test for non-normally distributed variables and the t test for normally distributed variables. The Fisher's exact test was applied for binary outcomes with an expected frequency below 5. Multivariate analysis was performed using binary logistic and linear regression models for dependent variables that were binary and continuous, respectively. All analyses were performed using SPSS (IBM SPSS Statistics for Windows Version 20.0; IBM Corp, Armonk, NY); a P-value under 0.05 was considered statistically significant. Results From January 1, 2004, to December 31, 2011, 1071 patients underwent colon cancer surgery. Of those patients, 329 (30.7%) had intraoperative adhesions, and in 138 (12.8%) of these patients the adhesions were considered dense. The remaining 742 (69.3%) patients were not reported to have any adhesions. Population characteristics The baseline characteristics of the study population are shown in Table 1. Sex, race, or body mass index distributions were not significantly different. The presence of adhesions was related to age at the time of operation, with an increase of the mean age from 65 years in the absence of adhesions to 70.1 years in all patients with adhesions and 71.6 years in those with dense adhesions (P<0.001 for both). As expected, the presence of adhesions was strongly related to a history of abdominal surgery; 29.6% of patients without adhesions had previous abdominal surgery, whereas 72.3% of those patients with adhesions and 76.8% of those with dense adhesions (P<0.001 for both) had previous surgery. Patients with dense adhesions also had more comorbidities (mean Charlson comorbidity score of 3.29 vs. 3.19; P=0.009) and a higher ASA score (mean score=2.58 vs. 2.34; P<0.001). In the group including all patients with adhesions, only the ASA score was significantly higher (2.42 vs. 2.34, P=0.012). There were no significant differences in smoking rates and the number of patients with symptomatic inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis). 140

8 Impact of adhesions on surgery and recovery Table 1. Baseline population characteristics at surgery Adhesions None All P-value Dense P-value Total, N (%) 742 (69.3) 329 (30.7) (12.8) - Age, mean, years ± SD 65 ± ±12.4 < ±13 <0.001 BMI, mean, kg/m 2 ± SD 27.4 ± ± ± Race (white) (%) Sex (male) (%) Previous of abdominal surgery (%) < <0.001 Current smoking (%) History of smoking (%) Diagnosis of Crohn's disease (%) Diagnosis of ulcerative colitis (%) ASA score, mean, ± SD 2.34 ± ± ±0.58 <0.001 Charlson score, mean, ± SD 3.19 ± ± ± BMI = body mass index; SD = standard deviation. Surgery-related complications As seen in Table 2, the presence of adhesions led to longer operative times, increasing the mean duration of surgery from 128 to 164 minutes (P<0.001). The rate of conversion in laparoscopic and hand-assisted laparoscopic cases also increased from 10.8% at baseline to 19.3% in all adhesions (P=0.055) and 38.5% in dense adhesions (P<0.001). Table 2. Surgery characteristics None (n=742) All (n=329) Adhesions P-value Dense (n=138) P-value Surgery duration, minutes, mean ± SD 128 ± ±91 < ±92 <0.001 Conversion (laparoscopic and hand assisted) (%) <0.001 Conversion (laparoscopic only) (%) SD = standard deviation. The same pattern, albeit with lower statistical significance, appeared when excluding hand-assisted approaches. Conversion rates were 11.5%, 19.6% (P=0.14), and 36.8% (P=0.003), respectively. 141

9 Chapter 10 Postoperative stay and complications As shown in Table 3, adhesions contribute to a longer postoperative stay, adding approximately a day to the average stay (from 6.3 to 7.38 days [P=0.005]). In patients with dense adhesions, this mean difference in stay duration doubles to over 2 additional days with an average duration of 8.74 days (P<0.001). However, adhesions did not significantly increase mortality, readmission, or reoperation rates within 30 days of the operation. Table 3. Stay duration and complications None (n=742) All (n=329) Adhesions P-value Dense (n=138) P-value Stay duration (mean, days) 6.30 ± ± ±9.4 <0.001 In-stay death, N (%) 12 (1.6) 4 (1.2) (2.2) day readmission rate, N (%) 58 (7.8) 24 (7.3) (8.7) day reoperation rate, N (%) 19 (2.6) 10 (3) (5.1) 0.11 An evaluation of differences in all postoperative complications that could possibly relate to adhesions is shown in Table 4. The only significant difference found was an increase in the rate of prolonged or returning to nothing by mouth (NPO) status from 4.7% to 7.9% in patients with adhesions (P=0.038) and with a strong trend of 8.7% in those patients with dense adhesions (P=0.056). Table 4. Postoperative complication rates None (n=742) n (%) All (n=329) n (%) Adhesions P-value Dense (n=138) n (%) Prolonged ileus In-stay 6 (8.8) 38 (11.6) (6.5) 0.38 Post-release 6 (0.8) 2 (0.6) P-value Total 71 (9.6) 40 (12.2) (6.5) 0.25 Anastomotic leak In-stay 12 (1.6) 3 (0.9) (0.7) 0.43 Post-release 4 (0.5) 1 (0.3) 1 1(0.7) 0.58 Total 16 (2.2) 4 (1.2) (1.4) 1 Wound dehiscence In-stay 3 (0.4) 1 (0.3) 1 1(0.7) 0.5 Post-release 1 (0.3) 2 (0.6) (0.7) 0.29 Total 4 (0.5) 3 (0.9) (1.4) 0.48 Wound Infection In-stay 39 (5.3) 23 (7) (6.5) 0.55 Post-release 9 (1.2) 4 (1.2) 1 3(2.2) 0.42 Total 47 (6.3) 27 (8.2) (8.7)

10 Impact of adhesions on surgery and recovery Table 4. Postoperative complication rates (continued) None (n=742) n (%) All (n=329) n (%) P Adhesions Dense (n=138) n (%) Gastrointestinal Bleed In-stay 2 (0.3) 1 (0.3) 1 1 (0.7) 0.40 Post-release 3 (0.4) Total 5 (0.7) 1(0.3) (0.7) 1 ICU Transfer In-stay 22 (3) 12 (3.6) (5.1) 0.2 Post-release 1 (0.1) Total 23 (3.1) 12 (3.6) (5.1) 0.3 NGT replacement In-stay 68 (9.2) 39 (11.9) (10.1) 0.72 Post-release 8 (1.1) 1 (0.3) (0.7) 1 Total 76 (10.2) 40 (12.2) (10.9) 0.82 Unplanned TPN In-stay 15 (2) 6 (1.8) (2.2) 0.75 Post-release 7 (0.9) 3 (0.9) 1 1 (0.7) 1 Total 22 (3.0) 9 (2.7) (2.9) 1 Unplanned NPO In-stay 31 (4.2) 23 (7.3) (8.7) Post-release 4 (0.5) 2 (0.6) Total 35 (4.7) 26 (7.9) (8.7) Bowel perforation In-stay 3 (0.4) 2(0.6) (0.7) 0.5 Post-release 0 0 N/A 0 N/A Total 3 (0.4) 2 (0.7) (0.7).5 Bowel obstruction In-stay 3 (0.4) 2 (0.6) (1.4).18 Post-release 4 (0.5) 2 (0.6) Total 7 (0.9) 4 (1.4) (1.3) 0.64 Colitis In-stay 6 (0.8) 4 (1.2) (2.9) 0.57 Post-release 3 (0.4) Total 8 (1.1) 4 (1.2) (3.5) 0.1 Sepsis In-stay 11 (1.5) 3 (0.9) (1.4) 1 Post-release 0 2 (0.6) (0.7) 0.16 Total 11 (1.5) 5 (1.5) 1 3 (2.2) 0.47 ICU = intensive care unit; NGT = nasogastric tube; NPO = nothing by mouth; TPN = total parenteral nutrition. Multivariate analysis Using multivariate models correcting for any significant covariates, all initial findings were confirmed; after correction for age and comorbidities in linear regression, patients with adhesions still had significantly longer operation times (both P<0.001) and longer P 143

11 Chapter 10 hospitalizations (P=0.029 for all adhesions and P<0.001 for dense adhesions). Conversion rates and prolonged and resumed NPO status also had unchanged significance levels after binary logistic regression, which included a significant increase in odds of conversion in sense adhesions (odds ratio (OR)=5.15, P<0.001) and a significant increase in the odds of unexpected NPO status in overall adhesions (OR=1.75, P=0.037). Table 5 displays these results in further detail. Table 5. Multivariate regression between the presence of adhesions and dependent variables controlling for significant covariates All adhesions Dense adhesions Beta P-value Beta P-value Linear regression Surgery duration (age, Charlson) < <0.001 Stay duration (age, Charlson) <0.001 Odds ratio P-value Odds ratio P-value Logistic regression Conversion (none) <0.001 NPO complication (Charlson) NPO = Nil Per Os -nothing by mouth Comments The impact of postoperative adhesions on long-term outcomes has been widely studied. However, there are still questions about the implications for patients who are about to undergo abdominal surgery and are expected to have adhesions. Specific evidence for colon cancer patients is even sparser. Because colon cancer patients tend to be among the oldest groups of patients undergoing major abdominal surgery, they are expected to have a higher incidence of previous abdominal surgeries and a higher comorbidity burden. Our intent was to measure the impact of adhesions in the perioperative setting in a large population of surgically treated colon cancer patients. We did so by comparing outcomes and complication rates during surgery and up to 30 days postoperatively. We found that adhesions were more frequent in older patients and in patients with higher Charlson comorbidity and ASA scores. Our findings confirm what one intuitively thinks, which is that adhesiolysis drastically lengthens operation duration, adding 40 minutes on average to a surgery that has a mean duration of 2 hours, thereby lengthening an average colon cancer surgery by 33%. Adhesions 144

12 Impact of adhesions on surgery and recovery complicate minimally invasive resections by leading to a 2- to 3-fold increase of conversion rates. In terms of postoperative recovery, an extensive evaluation of all major postoperative complications revealed only increased odds of having a delayed postoperative bowel function. Patients with adhesions subsequently had a significantly longer hospital stay, with a doubling of this effect in patients with dense adhesions. The link between adhesions and longer operation times confirms earlier suggestions by Coleman et al. 10 and Beck et al., 11 whereas the increase in conversion rates reiterates several reports that described the finding in other abdominal surgeries No further differences in complication rates were identified. A longer stay without increased complication rates is an indication that patients with adhesions do not have longer hospitalizations because of complications during their recovery but rather because of delayed gastrointestinal function from adhesiolysis as supported by the finding of a higher incidence of prolonged or resumed NPO status. This finding confirms a previous report describing higher rates of parenteral nutrition use in patients with adhesion-related inadvertent enterotomy. 15 An important limitation of this type of study is that it carries the inherent burden of reporting bias. The data collected here is based on operation and discharge reports. Meanwhile, it is quite conceivable that individual surgeons have different considerations on whether to report adhesions and how to describe these. However, the subjective judgment of the individual surgeon is an inherent limitation of this type of retrospective research, and by including over 1000 patients, we attempted to contain this effect as much as realistically possible. Furthermore, the overwhelming majority of our operative notes are dictated by attending surgeons within 12 hours of the operation, which hopefully increases accuracy and decreases recall bias. It is also possible that surgical learning curves impacted outcomes particularly in laparoscopic procedures. However, our population spans a time period that starts many years after the introduction of laparoscopic colectomies for colon cancer at our center. Whether there was still bias related to the learning curve and dealing with adhesions laparoscopically is unknown but doubtful considering the level of experience of our surgeons with laparoscopic procedures at the start of this patient series in It has also already been reported that many complications are underreported in discharge reports. 16, 17 However, an important nuance to add is that this supposed underreporting will probably cause a reporting bias that would favor more detailed reporting of the most complex cases. This could actually make it more likely to find significantly higher 145

13 Chapter 10 complication rates in the adhesions group, especially because they have higher Charlson comorbidity and ASA scores. Despite finding this link between higher comorbidity scores and adhesions, complication rates did not significantly differ. Even with a possible underreporting of complication rates, our population remains large enough to draw reliable conclusions from our statistical outcomes. In other words, it allows us to show with a reasonable level of certainty that the impact of pre-existent adhesions on short-term postoperative complications is low. In conclusion, our findings prove that pre-existing adhesions increase the operative and postoperative burden by significantly lengthening the surgical procedure, by increasing conversion rates, and by extending stay duration by leading to delayed gastrointestinal motility. Conversely, we can also conclude that these pre-existing adhesions do not cause more complications in a patient's postoperative course in our colon cancer population. 146

14 Impact of adhesions on surgery and recovery References 1. Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 2001;18(4): Beck DE, Opelka FG, Bailey HR, Rauh SM, Pashos CL. Incidence of small-bowel obstruction and adhesiolysis after open colorectal and general surgery. Dis. Colon Rectum Feb;42(2): Meagher AP, Farouk R, Dozois RR, Kelly KA, Pemberton JH. J ileal pouch-anal anastomosis for chronic ulcerative colitis: complications and long-term outcome in 1310 patients. Br J Surg Jun;85(6): Barmparas G, Branco BC, Schnüriger B, Lam L, Inaba K, Demetriades D. The incidence and risk factors of post-laparotomy adhesive small bowel obstruction. J. Gastrointest. Surg Oct;14(10): Ehrenfeld JM, Seim AR, Berger DL, Sandberg WS. Implementation of a direct-fromrecovery-room discharge pathway: a process improvement effort. Surg Innov. 2009;16(3): Pandya S, Murray JJ, Coller JA, Rusin LC. Laparoscopic colectomy: indications for conversion to laparotomy. Arch Surg May;134(5): van Goor HH. Consequences and complications of peritoneal adhesions. Colorectal Dis Oct 1;9 Suppl 2: Binenbaum SJ, Goldfarb MA. Inadvertent enterotomy in minimally invasive abdominal surgery. JSLS Jul;10(3): Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5): Coleman MG, McLain AD, Moran BJ. Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Dis. Colon Rectum Sep;43(9): Beck DE, Ferguson MA, Opelka FG, Fleshman JW, Gervaz P, Wexner SD. Effect of previous surgery on abdominal opening time. Dis. Colon Rectum Dec;43(12): Schwartz ML, Drew RL, Chazin-Caldie M. Factors determining conversion from laparoscopic to open Roux-en-Y gastric bypass. Obes Surg Oct;14(9): Sokol AI, Chuang K, Milad MP. Risk factors for conversion to laparotomy during gynecologic laparoscopy. J Am Assoc Gynecol Laparosc Nov;10(4): Perrone JM, Soper NJ, Eagon JC, Klingensmith ME, Aft RL, Frisella MM, et al. Perioperative outcomes and complications of laparoscopic ventral hernia repair. Surgery Oct;138(4): discussion Van Der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, Reijnen MM, Schaapveld M, van Goor H. Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg Apr;87(4): Bertges DJ, Shackford SR, Cloud AK, Stiles J, Stanley AC, Steinthorsson G, et al. Toward optimal recording of surgical complications: concurrent tracking compared to the discharge data set. Surgery Jan;141(1): Wanzel KR, Jamieson CG, Bohnen JM. Complications on a general surgery service: incidence and reporting. Can J Surg Apr;43(2):

The impact of adhesions on operations and postoperative recovery in colon cancer surgery

The impact of adhesions on operations and postoperative recovery in colon cancer surgery The American Journal of Surgery (2013) -, - - The impact of adhesions on operations and postoperative recovery in colon cancer surgery Ramzi Amri, M.Sc., Hannah C. den Boon, B.Sc., Liliana G. Bordeianou,

More information

Citation for published version (APA): Bartels, S. A. L. (2013). Laparoscopic colorectal surgery: beyond the short-term effects

Citation for published version (APA): Bartels, S. A. L. (2013). Laparoscopic colorectal surgery: beyond the short-term effects UvA-DARE (Digital Academic Repository) Laparoscopic colorectal surgery: beyond the short-term effects Bartels, S.A.L. Link to publication Citation for published version (APA): Bartels, S. A. L. (2013).

More information

Inadvertent Enterotomy in Minimally Invasive Abdominal Surgery

Inadvertent Enterotomy in Minimally Invasive Abdominal Surgery SCIENTIFIC PAPER Inadvertent Enterotomy in Minimally Invasive Abdominal Surgery Steven J. Binenbaum, MD, Michael A. Goldfarb, MD ABSTRACT Background: Inadvertent enterotomy (IE) in laparoscopic abdominal

More information

UvA-DARE (Digital Academic Repository) Improving aspects of palliative care for children Jagt, C.T. Link to publication

UvA-DARE (Digital Academic Repository) Improving aspects of palliative care for children Jagt, C.T. Link to publication UvA-DARE (Digital Academic Repository) Improving aspects of palliative care for children Jagt, C.T. Link to publication Citation for published version (APA): Jagt, C. T. (2017). Improving aspects of palliative

More information

Prediction of toxicity in concurrent chemoradiation for non-small cell lung cancer Uijterlinde, W.I.

Prediction of toxicity in concurrent chemoradiation for non-small cell lung cancer Uijterlinde, W.I. UvA-DARE (Digital Academic Repository) Prediction of toxicity in concurrent chemoradiation for non-small cell lung cancer Uijterlinde, W.I. Link to publication Citation for published version (APA): Uijterlinde,

More information

UvA-DARE (Digital Academic Repository) An electronic nose in respiratory disease Dragonieri, S. Link to publication

UvA-DARE (Digital Academic Repository) An electronic nose in respiratory disease Dragonieri, S. Link to publication UvA-DARE (Digital Academic Repository) An electronic nose in respiratory disease Dragonieri, S. Link to publication Citation for published version (APA): Dragonieri, S. (2012). An electronic nose in respiratory

More information

Gezinskenmerken: De constructie van de Vragenlijst Gezinskenmerken (VGK) Klijn, W.J.L.

Gezinskenmerken: De constructie van de Vragenlijst Gezinskenmerken (VGK) Klijn, W.J.L. UvA-DARE (Digital Academic Repository) Gezinskenmerken: De constructie van de Vragenlijst Gezinskenmerken (VGK) Klijn, W.J.L. Link to publication Citation for published version (APA): Klijn, W. J. L. (2013).

More information

SCIENTIFIC PAPER ABSTRACT INTRODUCTION METHODS

SCIENTIFIC PAPER ABSTRACT INTRODUCTION METHODS SCIENTIFIC PAPER The Influence of Prior Abdominal Operations on Conversion and Complication Rates in Laparoscopic Colorectal Surgery Jan Franko, MD, PhD, Brendan G. O Connell, MD, John R. Mehall, MD, Steven

More information

UvA-DARE (Digital Academic Repository) Vascular factors in dementia and apathy Eurelings, Lisa. Link to publication

UvA-DARE (Digital Academic Repository) Vascular factors in dementia and apathy Eurelings, Lisa. Link to publication UvA-DARE (Digital Academic Repository) Vascular factors in dementia and apathy Eurelings, Lisa Link to publication Citation for published version (APA): Eurelings, L. S. M. (2016). Vascular factors in

More information

Clinimetrics, clinical profile and prognosis in early Parkinson s disease Post, B.

Clinimetrics, clinical profile and prognosis in early Parkinson s disease Post, B. UvA-DARE (Digital Academic Repository) Clinimetrics, clinical profile and prognosis in early Parkinson s disease Post, B. Link to publication Citation for published version (APA): Post, B. (2009). Clinimetrics,

More information

Characterizing scaphoid nonunion deformity using 2-D and 3-D imaging techniques ten Berg, P.W.L.

Characterizing scaphoid nonunion deformity using 2-D and 3-D imaging techniques ten Berg, P.W.L. UvA-DARE (Digital Academic Repository) Characterizing scaphoid nonunion deformity using 2-D and 3-D imaging techniques ten Berg, P.W.L. Link to publication Citation for published version (APA): ten Berg,

More information

University of Groningen. Colorectal Anastomoses Bakker, Ilsalien

University of Groningen. Colorectal Anastomoses Bakker, Ilsalien University of Groningen Colorectal Anastomoses Bakker, Ilsalien IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document

More information

Advances in Abdominal Aortic Aneurysm Care - Towards personalized, centralized and endovascular care van Beek, S.C.

Advances in Abdominal Aortic Aneurysm Care - Towards personalized, centralized and endovascular care van Beek, S.C. UvA-DARE (Digital Academic Repository) Advances in Abdominal Aortic Aneurysm Care - Towards personalized, centralized and endovascular care van Beek, S.C. Link to publication Citation for published version

More information

Citation for published version (APA): Diederen, K. (2018). Pediatric inflammatory bowel disease: Monitoring, nutrition and surgery.

Citation for published version (APA): Diederen, K. (2018). Pediatric inflammatory bowel disease: Monitoring, nutrition and surgery. UvA-DARE (Digital Academic Repository) Pediatric inflammatory bowel disease Diederen, K. Link to publication Citation for published version (APA): Diederen, K. (2018). Pediatric inflammatory bowel disease:

More information

Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R.

Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. UvA-DARE (Digital Academic Repository) Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. Link to publication Citation for published version

More information

Citation for published version (APA): van der Paardt, M. P. (2015). Advances in MRI for colorectal cancer and bowel motility

Citation for published version (APA): van der Paardt, M. P. (2015). Advances in MRI for colorectal cancer and bowel motility UvA-DARE (Digital Academic Repository) Advances in MRI for colorectal cancer and bowel motility van der Paardt, M.P. Link to publication Citation for published version (APA): van der Paardt, M. P. (2015).

More information

Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R.

Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. UvA-DARE (Digital Academic Repository) Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. Link to publication Citation for published version

More information

Citation for published version (APA): Wijkerslooth de Weerdesteyn, T. R. (2013). Population screening for colorectal cancer by colonoscopy

Citation for published version (APA): Wijkerslooth de Weerdesteyn, T. R. (2013). Population screening for colorectal cancer by colonoscopy UvA-DARE (Digital Academic Repository) Population screening for colorectal cancer by colonoscopy de Wijkerslooth, T.R. Link to publication Citation for published version (APA): Wijkerslooth de Weerdesteyn,

More information

UvA-DARE (Digital Academic Repository) Tick-host-pathogen interactions in Lyme borreliosis Hovius, J.W.R. Link to publication

UvA-DARE (Digital Academic Repository) Tick-host-pathogen interactions in Lyme borreliosis Hovius, J.W.R. Link to publication UvA-DARE (Digital Academic Repository) Tick-host-pathogen interactions in Lyme borreliosis Hovius, J.W.R. Link to publication Citation for published version (APA): Hovius, J. W. R. (2009). Tick-host-pathogen

More information

Identifying and evaluating patterns of prescription opioid use and associated risks in Ontario, Canada Gomes, T.

Identifying and evaluating patterns of prescription opioid use and associated risks in Ontario, Canada Gomes, T. UvA-DARE (Digital Academic Repository) Identifying and evaluating patterns of prescription opioid use and associated risks in Ontario, Canada Gomes, T. Link to publication Citation for published version

More information

Iron and vitamin D deficiency in children living in Western-Europe Akkermans, M.D.

Iron and vitamin D deficiency in children living in Western-Europe Akkermans, M.D. UvA-DARE (Digital Academic Repository) Iron and vitamin D deficiency in children living in Western-Europe Akkermans, M.D. Link to publication Citation for published version (APA): Akkermans, M. D. (2017).

More information

Anxiety disorders in children with autism spectrum disorders: A clinical and health care economic perspective van Steensel, F.J.A.

Anxiety disorders in children with autism spectrum disorders: A clinical and health care economic perspective van Steensel, F.J.A. UvA-DARE (Digital Academic Repository) Anxiety disorders in children with autism spectrum disorders: A clinical and health care economic perspective van Steensel, F.J.A. Link to publication Citation for

More information

UvA-DARE (Digital Academic Repository)

UvA-DARE (Digital Academic Repository) UvA-DARE (Digital Academic Repository) Brain training improves recovery after stroke but waiting list improves equally: A multicenter randomized controlled trial of a computer-based cognitive flexibility

More information

AMORE (Ablative surgery, MOulage technique brachytherapy and REconstruction) for childhood head and neck rhabdomyosarcoma Buwalda, J.

AMORE (Ablative surgery, MOulage technique brachytherapy and REconstruction) for childhood head and neck rhabdomyosarcoma Buwalda, J. UvA-DARE (Digital Academic Repository) AMORE (Ablative surgery, MOulage technique brachytherapy and REconstruction) for childhood head and neck rhabdomyosarcoma Buwalda, J. Link to publication Citation

More information

Fecal Microbiota Transplantation: Clinical and experimental studies van Nood, E.

Fecal Microbiota Transplantation: Clinical and experimental studies van Nood, E. UvA-DARE (Digital Academic Repository) Fecal Microbiota Transplantation: Clinical and experimental studies van Nood, E. Link to publication Citation for published version (APA): van Nood, E. (2015). Fecal

More information

Citation for published version (APA): Luijendijk, P. (2014). Aortic coarctation: late complications and treatment strategies.

Citation for published version (APA): Luijendijk, P. (2014). Aortic coarctation: late complications and treatment strategies. UvA-DARE (Digital Academic Repository) Aortic coarctation: late complications and treatment strategies Luijendijk, P. Link to publication Citation for published version (APA): Luijendijk, P. (2014). Aortic

More information

Gastrointestinal Feedings Post Op: What s the deal on beginning oral feedings?

Gastrointestinal Feedings Post Op: What s the deal on beginning oral feedings? Gastrointestinal Feedings Post Op: What s the deal on beginning oral feedings? Kate Willcutts, DCN, RD, CNSC University of Virginia Health System Charlottesville, VA kfw3w@virginia.edu Objectives 1. Discuss

More information

Building blocks for return to work after sick leave due to depression de Vries, Gabe

Building blocks for return to work after sick leave due to depression de Vries, Gabe UvA-DARE (Digital Academic Repository) Building blocks for return to work after sick leave due to depression de Vries, Gabe Link to publication Citation for published version (APA): de Vries, G. (2016).

More information

UvA-DARE (Digital Academic Repository) Functional defecation disorders in children Kuizenga-Wessel, S. Link to publication

UvA-DARE (Digital Academic Repository) Functional defecation disorders in children Kuizenga-Wessel, S. Link to publication UvA-DARE (Digital Academic Repository) Functional defecation disorders in children Kuizenga-Wessel, S. Link to publication Citation for published version (APA): Kuizenga-Wessel, S. (2017). Functional defecation

More information

Impact of Screening Colonoscopy on Outcomes in Colon Cancer Surgery

Impact of Screening Colonoscopy on Outcomes in Colon Cancer Surgery Impact of Screening Colonoscopy on Outcomes in Colon Cancer Surgery The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation

More information

Dual-therapy stent technology for patients with coronary artery disease Kalkman, D.N.

Dual-therapy stent technology for patients with coronary artery disease Kalkman, D.N. UvA-DARE (Digital Academic Repository) Dual-therapy stent technology for patients with coronary artery disease Kalkman, D.N. Link to publication Citation for published version (APA): Kalkman, D. N. (2018).

More information

Longterm Complications of Hand-Assisted Versus Laparoscopic Colectomy

Longterm Complications of Hand-Assisted Versus Laparoscopic Colectomy Longterm Complications of Hand-Assisted Versus Laparoscopic Colectomy Toyooki Sonoda, MD, Sushil Pandey, MD, Koiana Trencheva, BSN, Sang Lee, MD, Jeffrey Milsom, MD, FACS BACKGROUND: STUDY DESIGN: Hand-assisted

More information

UvA-DARE (Digital Academic Repository) The systemic right ventricle van der Bom, T. Link to publication

UvA-DARE (Digital Academic Repository) The systemic right ventricle van der Bom, T. Link to publication UvA-DARE (Digital Academic Repository) The systemic right ventricle van der Bom, T. Link to publication Citation for published version (APA): van der Bom, T. (2014). The systemic right ventricle. General

More information

UvA-DARE (Digital Academic Repository) The artificial pancreas Kropff, J. Link to publication

UvA-DARE (Digital Academic Repository) The artificial pancreas Kropff, J. Link to publication UvA-DARE (Digital Academic Repository) The artificial pancreas Kropff, J. Link to publication Citation for published version (APA): Kropff, J. (2017). The artificial pancreas: From logic to life General

More information

UvA-DARE (Digital Academic Repository)

UvA-DARE (Digital Academic Repository) UvA-DARE (Digital Academic Repository) Clinical studies and tissue analyses in the earliest phases of rheumatoid arthritis: In search of the transition from being at risk to having clinically apparent

More information

Use of the comprehensive geriatric assessment to improve patient-centred care in complex patient populations Parlevliet, J.L.

Use of the comprehensive geriatric assessment to improve patient-centred care in complex patient populations Parlevliet, J.L. UvA-DARE (Digital Academic Repository) Use of the comprehensive geriatric assessment to improve patient-centred care in complex patient populations Parlevliet, J.L. Link to publication Citation for published

More information

Fast Track Surgery and Surgical Carepath in Optimising Colorectal Surgery. R Sim Centre for Advanced Laparoscopic Surgery, TTSH

Fast Track Surgery and Surgical Carepath in Optimising Colorectal Surgery. R Sim Centre for Advanced Laparoscopic Surgery, TTSH Fast Track Surgery and Surgical Carepath in Optimising Colorectal Surgery R Sim Centre for Advanced Laparoscopic Surgery, TTSH Conventional Surgery Postop care Nasogastric tube Enteral feeds when ileus

More information

Citation for published version (APA): de Groof, E. J. (2017). Surgery and medical therapy in Crohn s disease: Improving treatment strategies

Citation for published version (APA): de Groof, E. J. (2017). Surgery and medical therapy in Crohn s disease: Improving treatment strategies UvA-DARE (Digital Academic Repository) Surgery and medical therapy in Crohn s disease de Groof, E.J. Link to publication Citation for published version (APA): de Groof, E. J. (2017). Surgery and medical

More information

Tobacco control policies and socio-economic inequalities in smoking cessation Bosdriesz, J.R.

Tobacco control policies and socio-economic inequalities in smoking cessation Bosdriesz, J.R. UvA-DARE (Digital Academic Repository) Tobacco control policies and socio-economic inequalities in smoking cessation Bosdriesz, J.R. Link to publication Citation for published version (APA): Bosdriesz,

More information

UvA-DARE (Digital Academic Repository) Outcome and treatment of acute diverticulitis Ünlü, Çada. Link to publication

UvA-DARE (Digital Academic Repository) Outcome and treatment of acute diverticulitis Ünlü, Çada. Link to publication UvA-DARE (Digital Academic Repository) Outcome and treatment of acute diverticulitis Ünlü, Çada Link to publication Citation for published version (APA): Ünlü, Ç. (2014). Outcome and treatment of acute

More information

Enzyme replacement therapy in Fabry disease, towards individualized treatment Arends, M.

Enzyme replacement therapy in Fabry disease, towards individualized treatment Arends, M. UvA-DARE (Digital Academic Repository) Enzyme replacement therapy in Fabry disease, towards individualized treatment Arends, M. Link to publication Citation for published version (APA): Arends, M. (2017).

More information

UvA-DARE (Digital Academic Repository) Genetic basis of hypertrophic cardiomyopathy Bos, J.M. Link to publication

UvA-DARE (Digital Academic Repository) Genetic basis of hypertrophic cardiomyopathy Bos, J.M. Link to publication UvA-DARE (Digital Academic Repository) Genetic basis of hypertrophic cardiomyopathy Bos, J.M. Link to publication Citation for published version (APA): Bos, J. M. (2010). Genetic basis of hypertrophic

More information

Enhanced Recovery after Surgery - A Colorectal Perspective. R Sim Centre for Advanced Laparoscopic Surgery, TTSH

Enhanced Recovery after Surgery - A Colorectal Perspective. R Sim Centre for Advanced Laparoscopic Surgery, TTSH Enhanced Recovery after Surgery - A Colorectal Perspective R Sim Centre for Advanced Laparoscopic Surgery, TTSH Conventional Surgery Postop care Nasogastric tube Enteral feeds when ileus resolves Opioid

More information

UvA-DARE (Digital Academic Repository)

UvA-DARE (Digital Academic Repository) UvA-DARE (Digital Academic Repository) Standaarden voor kerndoelen basisonderwijs : de ontwikkeling van standaarden voor kerndoelen basisonderwijs op basis van resultaten uit peilingsonderzoek van der

More information

Diagnostic research in perspective: examples of retrieval, synthesis and analysis Bachmann, L.M.

Diagnostic research in perspective: examples of retrieval, synthesis and analysis Bachmann, L.M. UvA-DARE (Digital Academic Repository) Diagnostic research in perspective: examples of retrieval, synthesis and analysis Bachmann, L.M. Link to publication Citation for published version (APA): Bachmann,

More information

Repeat Single Incision Laparoscopic Surgery after Primary Single Incision Laparoscopic Surgery for Colorectal Disease

Repeat Single Incision Laparoscopic Surgery after Primary Single Incision Laparoscopic Surgery for Colorectal Disease ORIGINAL ARTICLE pissn 2234-778X eissn 2234-5248 J Minim Invasive Surg 2018;21(1):38-42 Journal of Minimally Invasive Surgery Repeat Single Incision Laparoscopic Surgery after Primary Single Incision Laparoscopic

More information

Citation for published version (APA): van der Put, C. E. (2011). Risk and needs assessment for juvenile delinquents

Citation for published version (APA): van der Put, C. E. (2011). Risk and needs assessment for juvenile delinquents UvA-DARE (Digital Academic Repository) Risk and needs assessment for juvenile delinquents van der Put, C.E. Link to publication Citation for published version (APA): van der Put, C. E. (2011). Risk and

More information

Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R.

Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. UvA-DARE (Digital Academic Repository) Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. Link to publication Citation for published version

More information

Citation for published version (APA): van de Vijver, S. J. M. (2015). Cardiovascular disease prevention in the slums of Kenya

Citation for published version (APA): van de Vijver, S. J. M. (2015). Cardiovascular disease prevention in the slums of Kenya UvA-DARE (Digital Academic Repository) Cardiovascular disease prevention in the slums of Kenya van de Vijver, Steven Link to publication Citation for published version (APA): van de Vijver, S. J. M. (2015).

More information

UvA-DARE (Digital Academic Repository) Gastrointestinal consequences of bariatric surgery Boerlage, T.C.C. Link to publication

UvA-DARE (Digital Academic Repository) Gastrointestinal consequences of bariatric surgery Boerlage, T.C.C. Link to publication UvA-DARE (Digital Academic Repository) Gastrointestinal consequences of bariatric surgery Boerlage, T.C.C. Link to publication Citation for published version (APA): Boerlage, T. C. C. (2018). Gastrointestinal

More information

UvA-DARE (Digital Academic Repository) What tumor cells cannot resist Ebbing, E.A. Link to publication

UvA-DARE (Digital Academic Repository) What tumor cells cannot resist Ebbing, E.A. Link to publication UvA-DARE (Digital Academic Repository) What tumor cells cannot resist Ebbing, E.A. Link to publication Citation for published version (APA): Ebbing, E. A. (2018). What tumor cells cannot resist: Mechanisms

More information

Citation for published version (APA): Parigger, E. M. (2012). Language and executive functioning in children with ADHD Den Bosch: Boxpress

Citation for published version (APA): Parigger, E. M. (2012). Language and executive functioning in children with ADHD Den Bosch: Boxpress UvA-DARE (Digital Academic Repository) Language and executive functioning in children with ADHD Parigger, E.M. Link to publication Citation for published version (APA): Parigger, E. M. (2012). Language

More information

Thirty-Day Outcomes of Laparoscopic vs. Open Total Proctocolectomy with Ileoanal Anastomosis in Children

Thirty-Day Outcomes of Laparoscopic vs. Open Total Proctocolectomy with Ileoanal Anastomosis in Children Thirty-Day Outcomes of Laparoscopic vs. Open Total Proctocolectomy with Ileoanal Anastomosis in Children Jeremy D. Kauffman MD, Paul D. Danielson MD, Nicole M. Chandler MD Johns Hopkins All Children s

More information

Citation for published version (APA): Swank, H. A. (2012). Minimally invasive surgery for lower abdominal peritonitis

Citation for published version (APA): Swank, H. A. (2012). Minimally invasive surgery for lower abdominal peritonitis UvA-DARE (Digital Academic Repository) Minimally invasive surgery for lower abdominal peritonitis Swank, H.A. Link to publication Citation for published version (APA): Swank, H. A. (2012). Minimally invasive

More information

UvA-DARE (Digital Academic Repository) Marfan syndrome: Getting to the root of the problem Franken, Romy. Link to publication

UvA-DARE (Digital Academic Repository) Marfan syndrome: Getting to the root of the problem Franken, Romy. Link to publication UvA-DARE (Digital Academic Repository) Marfan syndrome: Getting to the root of the problem Franken, Romy Link to publication Citation for published version (APA): Franken, R. (2016). Marfan syndrome: Getting

More information

Risk factors for future repeat abdominal surgery

Risk factors for future repeat abdominal surgery Langenbecks Arch Surg (2016) 401:829 837 DOI 10.1007/s00423-016-1414-3 ORIGINAL ARTICLE Risk factors for future repeat abdominal surgery Chema Strik 1 & Martijn W. J. Stommel 1 & Laura J. Schipper 1 &

More information

Operational research on implementation of tuberculosis guidelines in Mozambique Brouwer, Miranda

Operational research on implementation of tuberculosis guidelines in Mozambique Brouwer, Miranda UvA-DARE (Digital Academic Repository) Operational research on implementation of tuberculosis guidelines in Mozambique Brouwer, Miranda Link to publication Citation for published version (APA): Brouwer,

More information

Functional abdominal pain disorders in children: therapeutic strategies focusing on hypnotherapy Rutten, J.M.T.M.

Functional abdominal pain disorders in children: therapeutic strategies focusing on hypnotherapy Rutten, J.M.T.M. UvA-DARE (Digital Academic Repository) Functional abdominal pain disorders in children: therapeutic strategies focusing on hypnotherapy Rutten, J.M.T.M. Link to publication Citation for published version

More information

Thyroid disease and haemostasis: a relationship with clinical implications? Squizzato, A.

Thyroid disease and haemostasis: a relationship with clinical implications? Squizzato, A. UvA-DARE (Digital Academic Repository) Thyroid disease and haemostasis: a relationship with clinical implications? Squizzato, A. Link to publication Citation for published version (APA): Squizzato, A.

More information

Kawasaki disease: Studies on etiology, treatment and long-term follow-up Tacke, C.E.A.

Kawasaki disease: Studies on etiology, treatment and long-term follow-up Tacke, C.E.A. UvA-DARE (Digital Academic Repository) Kawasaki disease: Studies on etiology, treatment and long-term follow-up Tacke, C.E.A. Link to publication Citation for published version (APA): Tacke, C. E. A. (2014).

More information

The role of media entertainment in children s and adolescents ADHD-related behaviors: A reason for concern? Nikkelen, S.W.C.

The role of media entertainment in children s and adolescents ADHD-related behaviors: A reason for concern? Nikkelen, S.W.C. UvA-DARE (Digital Academic Repository) The role of media entertainment in children s and adolescents ADHD-related behaviors: A reason for concern? Nikkelen, S.W.C. Link to publication Citation for published

More information

UvA-DARE (Digital Academic Repository) Falling: should one blame the heart? Jansen, Sofie. Link to publication

UvA-DARE (Digital Academic Repository) Falling: should one blame the heart? Jansen, Sofie. Link to publication UvA-DARE (Digital Academic Repository) Falling: should one blame the heart? Jansen, Sofie Link to publication Citation for published version (APA): Jansen, S. (2015). Falling: should one blame the heart?

More information

DIVERTICULAR DISEASE. Dr. Irina Murray Casanova PGY IV

DIVERTICULAR DISEASE. Dr. Irina Murray Casanova PGY IV DIVERTICULAR DISEASE Dr. Irina Murray Casanova PGY IV Diverticular Disease Colonoscopy Abdpelvic CT Scan Surgical Indications Overall, approximately 20% of patients with diverticulitis require surgical

More information

Antimicrobial drug resistance at the human-animal interface in Vietnam Nguyen, V.T.

Antimicrobial drug resistance at the human-animal interface in Vietnam Nguyen, V.T. UvA-DARE (Digital Academic Repository) Antimicrobial drug resistance at the human-animal interface in Vietnam Nguyen, V.T. Link to publication Citation for published version (APA): Nguyen, V. T. (2017).

More information

Citation for published version (APA): Lammers-van der Holst, H. M. (2016). Individual differences in shift work tolerance

Citation for published version (APA): Lammers-van der Holst, H. M. (2016). Individual differences in shift work tolerance UvA-DARE (Digital Academic Repository) Individual differences in shift work tolerance Lammers-van der Holst, H.M. Link to publication Citation for published version (APA): Lammers-van der Holst, H. M.

More information

ERAS. Presented by Timothy L. Beard MD, FACS, CPI Bend Memorial Clinic

ERAS. Presented by Timothy L. Beard MD, FACS, CPI Bend Memorial Clinic ERAS Presented by Timothy L. Beard MD, FACS, CPI Bend Memorial Clinic Outline Definition Justification Ileus Pain Outline Specifics Data BMC Data Worldwide Data Implementation What is ERAS? AKA Fast-track

More information

UvA-DARE (Digital Academic Repository) Genetic variation in Helicobacter pylori Pan, Z. Link to publication

UvA-DARE (Digital Academic Repository) Genetic variation in Helicobacter pylori Pan, Z. Link to publication UvA-DARE (Digital Academic Repository) Genetic variation in Helicobacter pylori Pan, Z. Link to publication Citation for published version (APA): Pan, Z. (1999). Genetic variation in Helicobacter pylori

More information

Citation for published version (APA): Sivapalaratnam, S. (2012). The molecular basis of early onset cardiovascular disease

Citation for published version (APA): Sivapalaratnam, S. (2012). The molecular basis of early onset cardiovascular disease UvA-DARE (Digital Academic Repository) The molecular basis of early onset cardiovascular disease Sivapalaratnam, S. Link to publication Citation for published version (APA): Sivapalaratnam, S. (2012).

More information

Bariatric Surgery as an Ambulatory Procedure

Bariatric Surgery as an Ambulatory Procedure CENTRO DE EXCELENCIA PARA EL ESTUDIO Y TRATAMIENTO DE LA OBESIDAD Bariatric Surgery as an Ambulatory Procedure Miguel-A. Carbajo Caballero Director del Centro de Excelencia de Cirugía de la Obesidad y

More information

Familial hypercholesterolemia in childhood: diagnostics, therapeutical options and risk stratification Rodenburg, J.

Familial hypercholesterolemia in childhood: diagnostics, therapeutical options and risk stratification Rodenburg, J. UvADARE (Digital Academic Repository) Familial hypercholesterolemia in childhood: diagnostics, therapeutical options and risk stratification Rodenburg, J. Link to publication Citation for published version

More information

UvA-DARE (Digital Academic Repository) Anorectal malformations and hirschsprung disease Witvliet, M.J. Link to publication

UvA-DARE (Digital Academic Repository) Anorectal malformations and hirschsprung disease Witvliet, M.J. Link to publication UvA-DARE (Digital Academic Repository) Anorectal malformations and hirschsprung disease Witvliet, M.J. Link to publication Citation for published version (APA): Witvliet, M. J. (2017). Anorectal malformations

More information

Further insights into inheritable arrhythmia syndromes: Focus on electrocardiograms Postema, P.G.

Further insights into inheritable arrhythmia syndromes: Focus on electrocardiograms Postema, P.G. UvA-DARE (Digital Academic Repository) Further insights into inheritable arrhythmia syndromes: Focus on electrocardiograms Postema, P.G. Link to publication Citation for published version (APA): Postema,

More information

Citation for published version (APA): Zeddies, S. (2015). Novel regulators of megakaryopoiesis: The road less traveled by

Citation for published version (APA): Zeddies, S. (2015). Novel regulators of megakaryopoiesis: The road less traveled by UvA-DARE (Digital Academic Repository) Novel regulators of megakaryopoiesis: The road less traveled by Zeddies, S. Link to publication Citation for published version (APA): Zeddies, S. (2015). Novel regulators

More information

UvA-DARE (Digital Academic Repository) Toothbrushing efficacy Rosema, N.A.M. Link to publication

UvA-DARE (Digital Academic Repository) Toothbrushing efficacy Rosema, N.A.M. Link to publication UvA-DARE (Digital Academic Repository) Toothbrushing efficacy Rosema, N.A.M. Link to publication Citation for published version (APA): Rosema, N. A. M. (2015). Toothbrushing efficacy. General rights It

More information

Citation for published version (APA): Von Eije, K. J. (2009). RNAi based gene therapy for HIV-1, from bench to bedside

Citation for published version (APA): Von Eije, K. J. (2009). RNAi based gene therapy for HIV-1, from bench to bedside UvA-DARE (Digital Academic Repository) RNAi based gene therapy for HIV-1, from bench to bedside Von Eije, K.J. Link to publication Citation for published version (APA): Von Eije, K. J. (2009). RNAi based

More information

UvA-DARE (Digital Academic Repository) Obesity, ectopic lipids, and insulin resistance ter Horst, K.W. Link to publication

UvA-DARE (Digital Academic Repository) Obesity, ectopic lipids, and insulin resistance ter Horst, K.W. Link to publication UvA-DARE (Digital Academic Repository) Obesity, ectopic lipids, and insulin resistance ter Horst, K.W. Link to publication Citation for published version (APA): ter Horst, K. W. (2017). Obesity, ectopic

More information

Citation for published version (APA): Bartels, S. A. L. (2013). Laparoscopic colorectal surgery: beyond the short-term effects

Citation for published version (APA): Bartels, S. A. L. (2013). Laparoscopic colorectal surgery: beyond the short-term effects UvA-DARE (Digital Academic Repository) Laparoscopic colorectal surgery: beyond the short-term effects Bartels, S.A.L. Link to publication Citation for published version (APA): Bartels, S. A. L. (2013).

More information

UvA-DARE (Digital Academic Repository)

UvA-DARE (Digital Academic Repository) UvA-DARE (Digital Academic Repository) Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort Bartha, I.; Assel, M.; Sloot, P.M.A.;

More information

Citation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle cell disease in Ghana: Towards tailor-made interventions

Citation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle cell disease in Ghana: Towards tailor-made interventions UvA-DARE (Digital Academic Repository) Malaria, HIV and sickle cell disease in Ghana Owusu, E.D.A. Link to publication Citation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle

More information

Colostomy & Ileostomy

Colostomy & Ileostomy Colostomy & Ileostomy Indications, problems and preference By Waleed Omar Professor of Colorectal surgery, Mansoura University. Disclosure I have no disclosures. Presentation outline Stoma: Definition

More information

UvA-DARE (Digital Academic Repository) Mucorales between food and infection Dolat Abadi, S. Link to publication

UvA-DARE (Digital Academic Repository) Mucorales between food and infection Dolat Abadi, S. Link to publication UvA-DARE (Digital Academic Repository) Mucorales between food and infection Dolat Abadi, S. Link to publication Citation for published version (APA): Dolatabadi, S. (2015). Mucorales between food and infection

More information

Citation for published version (APA): van Munster, B. C. (2009). Pathophysiological studies in delirium : a focus on genetics.

Citation for published version (APA): van Munster, B. C. (2009). Pathophysiological studies in delirium : a focus on genetics. UvA-DARE (Digital Academic Repository) Pathophysiological studies in delirium : a focus on genetics van Munster, B.C. Link to publication Citation for published version (APA): van Munster, B. C. (2009).

More information

UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication

UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication Citation for published version (APA): Amri, R. (2015). Clinical issues in the

More information

UvA-DARE (Digital Academic Repository) Treatment of osteochondral defects of the talus van Bergen, C.J.A. Link to publication

UvA-DARE (Digital Academic Repository) Treatment of osteochondral defects of the talus van Bergen, C.J.A. Link to publication UvA-DARE (Digital Academic Repository) Treatment of osteochondral defects of the talus van Bergen, C.J.A. Link to publication Citation for published version (APA): van Bergen, C. J. A. (2014). Treatment

More information

Citation for published version (APA): Donker, M. (2014). Improvements in locoregional treatment of breast cancer

Citation for published version (APA): Donker, M. (2014). Improvements in locoregional treatment of breast cancer UvA-DARE (Digital Academic Repository) Improvements in locoregional treatment of breast cancer Donker, Mila Link to publication Citation for published version (APA): Donker, M. (2014). Improvements in

More information

Moving the brain: Neuroimaging motivational changes of deep brain stimulation in obsessive-compulsive disorder Figee, M.

Moving the brain: Neuroimaging motivational changes of deep brain stimulation in obsessive-compulsive disorder Figee, M. UvA-DARE (Digital Academic Repository) Moving the brain: Neuroimaging motivational changes of deep brain stimulation in obsessive-compulsive disorder Figee, M. Link to publication Citation for published

More information

Outcomes of Patients with Preoperative Weight Loss following Colorectal Surgery

Outcomes of Patients with Preoperative Weight Loss following Colorectal Surgery Outcomes of Patients with Preoperative Weight Loss following Colorectal Surgery Zhobin Moghadamyeghaneh MD 1, Michael J. Stamos MD 1 1 Department of Surgery, University of California, Irvine Nothing to

More information

CLINICAL IMPACT OF SEPRAFILM SAFETY AND EFFICACY

CLINICAL IMPACT OF SEPRAFILM SAFETY AND EFFICACY CLINICAL IMPACT OF Post-surgical ADHESIONS SEPRAFILM SAFETY AND EFFICACY Clinical Reviews Clinical studies contents OVERVIEW 3. REDUCED INCIDENCE AND SEVERITY OF ADHESIONS 3.1 Becker JM et al. (1996) 3.2

More information

ORIGINAL ARTICLE. Risk of Complications From Enterotomy or Unplanned Bowel Resection During Elective Hernia Repair

ORIGINAL ARTICLE. Risk of Complications From Enterotomy or Unplanned Bowel Resection During Elective Hernia Repair ORIGINAL ARTICLE Risk of Complications From Enterotomy or Unplanned Bowel Resection During Elective Hernia Repair Stephen H. Gray, MD; Catherine C. Vick, MS; Laura A. Graham, MPH; Kelly R. Finan, MD, MSPH;

More information

Significance of radiologically determined prognostic factors for head and neck cancer Lodder, W.L.

Significance of radiologically determined prognostic factors for head and neck cancer Lodder, W.L. UvA-DARE (Digital Academic Repository) Significance of radiologically determined prognostic factors for head and neck cancer Lodder, W.L. Link to publication Citation for published version (APA): Lodder,

More information

UvA-DARE (Digital Academic Repository) Surgical treatment of perianal and rectal fistula van Koperen, P.J. Link to publication

UvA-DARE (Digital Academic Repository) Surgical treatment of perianal and rectal fistula van Koperen, P.J. Link to publication UvA-DARE (Digital Academic Repository) Surgical treatment of perianal and rectal fistula van Koperen, P.J. Link to publication Citation for published version (APA): van Koperen, P. J. (2010). Surgical

More information

UvA-DARE (Digital Academic Repository) Intraarterial treatment for acute ischemic stroke Berkhemer, O.A. Link to publication

UvA-DARE (Digital Academic Repository) Intraarterial treatment for acute ischemic stroke Berkhemer, O.A. Link to publication UvA-DARE (Digital Academic Repository) Intraarterial treatment for acute ischemic stroke Berkhemer, O.A. Link to publication Citation for published version (APA): Berkhemer, O. A. (2016). Intraarterial

More information

UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication

UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication Citation for published version (APA): Amri, R. (2015). Clinical issues in the

More information

Inflammation in chronic obstructive pulmonary disease : its assessment and the effects of corticosteroids Boorsma, M.

Inflammation in chronic obstructive pulmonary disease : its assessment and the effects of corticosteroids Boorsma, M. UvA-DARE (Digital Academic Repository) Inflammation in chronic obstructive pulmonary disease : its assessment and the effects of corticosteroids Boorsma, M. Link to publication Citation for published version

More information

UvA-DARE (Digital Academic Repository) Malaria during pregnancy in Rwanda Rulisa, S. Link to publication

UvA-DARE (Digital Academic Repository) Malaria during pregnancy in Rwanda Rulisa, S. Link to publication UvA-DARE (Digital Academic Repository) Malaria during pregnancy in Rwanda Rulisa, S. Link to publication Citation for published version (APA): Rulisa, S. (2014). Malaria during pregnancy in Rwanda General

More information

Feasibility of Emergency Laparoscopic Reoperations for Complications after Laparoscopic Surgery for Colorectal Cancer

Feasibility of Emergency Laparoscopic Reoperations for Complications after Laparoscopic Surgery for Colorectal Cancer ORIGINAL ARTICLE pissn 2234-778X eissn 2234-5248 J Minim Invasive Surg 2018;21(2):70-74 Journal of Minimally Invasive Surgery Feasibility of Emergency Laparoscopic Reoperations for Complications after

More information

Citation for published version (APA): Azaripour, A. (2016). Structure and function of the human periodontium: Science meets the clinician

Citation for published version (APA): Azaripour, A. (2016). Structure and function of the human periodontium: Science meets the clinician UvA-DARE (Digital Academic Repository) Structure and function of the human periodontium Azaripour, A. Link to publication Citation for published version (APA): Azaripour, A. (2016). Structure and function

More information

Chapter I 7. Laparoscopic versus open elective sigmoid resection in diverticular disease: six months follow-up of the randomized control Sigma-trial

Chapter I 7. Laparoscopic versus open elective sigmoid resection in diverticular disease: six months follow-up of the randomized control Sigma-trial Chapter I 7 Laparoscopic versus open elective sigmoid resection in diverticular disease: six months follow-up of the randomized control Sigma-trial Bastiaan R. Klarenbeek Roberto Bergamaschi Alexander

More information

Citation for published version (APA): Braakhekke, M. W. M. (2017). Randomized controlled trials in reproductive medicine: Disclosing the caveats

Citation for published version (APA): Braakhekke, M. W. M. (2017). Randomized controlled trials in reproductive medicine: Disclosing the caveats UvA-DARE (Digital Academic Repository) Randomized controlled trials in reproductive medicine Braakhekke, M.W.M. Link to publication Citation for published version (APA): Braakhekke, M. W. M. (2017). Randomized

More information

Comparison of Risk Factors for Unplanned Conversion from Laparoscopic and Robotic to Open Colorectal Surgery

Comparison of Risk Factors for Unplanned Conversion from Laparoscopic and Robotic to Open Colorectal Surgery Comparison of Risk Factors for Unplanned Conversion from Laparoscopic and Robotic to Open Colorectal Surgery Abdullah Wafa, M.D. General Surgery Resident, PGY2 St. Joseph Mercy Health System Ann Arbor

More information