Clinical Follow-up of 96 Patients Affected by Irritable Bowel Syndrome Treated with a Novel Multi-strain Symbiotic

Size: px
Start display at page:

Download "Clinical Follow-up of 96 Patients Affected by Irritable Bowel Syndrome Treated with a Novel Multi-strain Symbiotic"

Transcription

1 Columbia International Publishing Journal of Contemporary Immunology doi: /jci Research Article Clinical Follow-up of 96 Patients Affected by Irritable Bowel Syndrome Treated with a Novel Multi-strain Symbiotic Renato Rossi 1, Lucilla Rossi 2, and Filippo Fassio 2* Received 25 February 2015; Published online 18 April 2015 The author(s) Published with open access at Abstract Irritable bowel syndrome (IBS) is a very common chronic functional disorder of the lower gastrointestinal tract. It tipically includes chronic and/or recurrent abdominal pain/discomfort, which can be relieved by defecation, and alteration of stool form or frequency. Probiotics have been proposed as a therapeutic approach in several pathologic conditions of the gastrointestinal tract associated with dysbiosis, including IBS. In this observational study we investigated the efficacy of a symbiotic formulation (SynGut TM ), composed of four probiotic strains and the prebiotic inulin, in the treatment of adult subjects affected by IBS. Seventy-one out of 96 patients reported an improvement of IBS symptoms, 19 of them reporting a substantial improvement. Two patients discontinued the treatment after a few days because of worsening of symptoms, but no serious adverse effects were reported. In the subgroup of patients (n = 18) who underwent faecal calprotectin dosage, this marker of gut inflammation was significantly decreased (127,3 vs 78,6, p < 0,0001) after two months of treatment respect to baseline. Our data confirm that this multi-strain symbiotic is well tolerated, and support the hypothesis that this symbiotic could improve IBS symptoms. Further studies and randomized trials with larger patient populations are needed to confirm this positive effect with particular focus on strain-specific outcomes, usefulness of concomitant prebiotic and probiotic supplementation, dose optimization, and other relevant manufacturing specifications. Keywords: Irritable bowel syndrome; Treatment; Probiotics; Prebiotics; Symbiotics 1. Introduction Irritable bowel syndrome (IBS) is a chronic functional disorder of the lower gastrointestinal tract. It is one of the most common gastrointestinal conditions worldwide, predominantly affecting younger people (symptoms frequently date back to childhood) and women (female/male ratio of 2:1) (Ford *Corresponding fassio.filippo@gmail.com 1 Vita-Salute San Raffaele University, Milan, Italy 2 Medicine Unit, ASL 3 Pistoia, Pistoia, Italy 49

2 and Talley 2012). Its prevalence, according to a systematic review, ranges from 7% in South East Asia to 21% in South America; in Europe, it is estimated that IBS affects around 12% of the population (Lovell and Ford 2012). It tipically includes chronic/recurrent abdominal pain/discomfort, which can be relieved by defecation, and alteration of stool form or frequency. Abdominal bloating can also be associated (Ford and Talley 2012). A patient without lower gastrointestinal alarm symptoms (which include weight loss, abdominal mass, rectal bleeding, heme positive stools or iron deficiency anemia, family history of colon cancer or age >50 years with no previous colon cancer screening), who shows longstanding typical symptoms of IBS can be diagnosed on clinical grounds with routine laboratory tests without the need of invasive investigative techniques (Ford and Talley 2012). Symptoms-based diagnostic criteria, known as Rome criteria, have been developed for this purpose and updated in 2006 (Longstreth et al. 2006) (Table 1). These criteria divide IBS patients according to the predominant stool form: patients are classified as constipation-predominant (IBS-C), diarrhea-predominant (IBS- D), or mixed (IBS-M). It must be underlined that not every patient can be classified according to these criteria (IBS-U, unclassified) and that stool form can change over time (Longstreth et al. 2006). Table 1 Rome criteria for diagnosis of IBS (Longstreth et al. 2006). Diagnostic Criteria* for Irritable Bowel Syndrome Recurrent abdominal pain or discomfort** for at least 3 days per month in the last 3 months associated with 2 or more of the following: 1. Improvement with defecation 2. Onset associated with a change of frequency of stool 3. Onset associated with a change in form (appearance) of stool * Criteria fulfilled for the last 3 months with symptom onset at least 6 months prior to diagnosis ** Discomfort means an uncomfortable sensation not described as pain. In pathophysiology research and clinical trials, a pain/discomfort frequency of al least 2 days a week during screening evaluation for subject eligibility. Quite often, as diagnosis remains uncertain, patients are referred to allergy clinics for a suspected food allergy/intolerance. Sometimes, IBS symptoms begin suddenly after a gastroenteritis and is therefore termed post-infectious IBS (PI-IBS) (Schwille-Kiuntke et al., 2011). PI-IBS has been reported after Campylobacter, Salmonella and Shigella infections of the gastroenteric tract (Spiller 2007). Biopsy specimens of the intestinal mucosa, obtained during a Campylobacter jejuni infection, showed an inflammatory infiltrate, with intraepithelial lymphocytes, calprotectin-positive macrophages and increase of enterochromaffin cells which in most cases persisted for the following six months (Spiller, 2007; Spiller et al., 2000). In these cases, it has also been documented an increase of interleukin (IL)-1β mrnas and of mucosal permeability. 50

3 Recent studies have demonstrated mast cell infiltration in the colic mucosa, with degranulation in proximity of mucosal nerve terminations. This could contribute to abdominal pain in IBS patients (Barbara et al., 2004). A direct association between IBS symptoms and psychological stress or psychiatric conditions has been observed (Mayer, Craske, and Naliboff 2001); given the frequent responsiveness of symptoms to neurotrophic therapies, IBS is often referred to as a brain-gut disorder, although its pathophysiology remains uncertain (Mayer and Paulley 2008). In a subject affected by IBS, accepting reported symptoms and distress as real while not minimizing them as a manifestation of anxiety and somatization, usually facilitates the establishment of a positive patient doctor relationship and the patient s compliance to proposed therapies (Mayer and Paulley 2008). Currently available drugs for the management of IBS usually target the management of individual symptoms, such as constipation, diarrhea, and abdominal pain (Mayer and Paulley 2008). The gut microbiota is a metabolically active complex ecosystem that plays an important role in health and in the pathogenesis of several diseases, not limited to the gastrointestinal tract (Whelan and Quigley 2013). Its composition varies significantly among individuals, being influenced by several factors including age, diet, and disease (Claesson et al. 2011). An increasing number of diseases is being associated to dysbiosis, from gastrointestinal diseases such as IBS and inflammatory bowel disease to extra-intestinal diseases such as obesity and diabetes (Shanahan 2013). Probiotics are live micro-organisms which produce a health benefit when administered in certain amounts to the host (Sanders et al. 2013). Prebiotics are dietary non-digestible ingredients that selectively stimulate the growth and activity of one or a limited number of bacterial species of the intestinal flora. Symbiotic is a combination of probiotic and prebiotic. This formulation allows an increase in the survival of the probiotic organisms, because it immediately makes its substrate available for fermentation (Manzotti, Heffler, Fassio, et al. 2014; Manzotti, Heffler, and Fassio 2014). In recent years, probiotics have been investigated in several pathologic conditions as an approach to modulate the gastrointestinal microbiota (O Mahony et al. 2005; Rousseaux et al. 2007; Meltzer et al. 2004; Wald and Rakel; Astegiano et al. 2008; Mitsuyama and Sata 2008; Seksik et al. 2008; Guandalini, Cernat, and Moscoso 2014). In this observational study we investigated the efficacy of a symbiotic formulation (SynGut TM, Allergy Therapeutics Italia, Milan, Italy), composed of four probiotic strains (Bifidobacterium lactis W51, Lactobacillus acidophilus W22, Lactobacillus plantarum W21, Lactococcus lactis W19) and the prebiotic inulin, in the treatment of adult subjects affected by IBS. 51

4 2. Materials and Methods The aim of this observational study was to evaluate the effect of the administration of a novel symbiotic multi-strain mixture for the management of IBS. An industrial combination of Bifidobacterium lactis W51 3.3x10 8 UFC/sachet, Lactobacillus acidophilus W UFC/sachet, Lactobacillus plantarum W21 3.3x10 8 UFC/sachet, Lactococcus lactis W19 3.3x10 8 UFC/sachet and inulin gr/sachet (SynGut TM, marketed by Allergy Therapeutics Italia, Milan, Italy; manufactured by Winclove Probiotics, Amsterdam, The Netherlands) was used in this study. This content is in agreement with the guidelines of the Italian Ministry of Health on probiotics (Italian Ministry of Health, 2013). A total of 96 adult subjects (54 females, mean age 34.8 years, range) affected by IBS according to Rome criteria (Longstreth et al. 2006), attending a single outpatient allergy clinic for a suspected food allergy/intolerance for the period of April 2013 to December 2015 were enrolled in the study. Each subject used 1 sachet per day for a period of two months. Patients were instructed to record improvement, persistence and/or worsening of IBS symptoms such as diarrhea, constipation, bloating, and abdominal pain/discomfort during the study period. A follow-up evaluation took place at the end of the two-month period, and patients underwent an oral interview during which they were asked if they experienced worsening, no significant improvement, partial improvement or substantial improvement of their IBS symptoms. In a subgroup of 18 patients, faecal calprotectin has been measured before and after symbiotic supplementation as a marker of gut inflammation(däbritz, Musci, and Foell 2014). Statistics were conducted using Excel Microsoft Office. 3. Results Of the 96 subjects evaluated, 94 took the symbiotic formulation once daily for two months, as the schedule prescribed, without reporting any adverse effect. Subjective evaluation of IBS symptoms after two months of SynGut TM supplementation in our study population is showed in Figure 1. Seventy-one patients reported an improvement of IBS symptoms, with 19 of them reporting a substantial improvement. Two patients discontinued the treatment after a few days because of worsening of symptoms, but no serious adverse effects were reported. In the subgroup of patients (n = 18) who underwent faecal calprotectin dosage, this marker of gut inflammation was significantly decreased (127,3 vs 78,6, p < 0,0001) after two months of SynGut TM supplementation in respect to the baseline (Figure 2). 52

5 Fig. 1. Subjective evaluation of IBS symptoms after 2 months of SynGut TM treatment. Fig. 2. Faecal calprotectin dosage at baseline and after 2 months of SynGut TM treatment. 53

6 4. Discussion Renato Rossi, Lucilla Rossi, and Filippo Fassio / Journal of Contemporary Immunology Bacterial fermentation has been associated with many IBS symptoms such as flatulence, abdominal distension, and bloating. Moreover, qualitative changes in the microbiota have been described in IBS, but the contribution of the microbiota to the pathogenesis of IBS is not completely understood (Ford, Quigley, et al. 2014). Nonetheless, recent studies have brought a greater understanding of probiotics mechanism of action in IBS. Some probiotics have considerable metabolic activity, including: capability of fermentation of nondigested carbohydrates and their conversion into short-chain fatty acids, modulation of the inflammatory response to some enteropathogens, vitamin synthesis and deconjugation of bile salts (Whelan and Quigley 2013). It has been demonstrated that some probiotics are capable of producing and secreting neurotransmitters and neuromodulators that modify some gastrointestinal functions, such as motility or visceral sensation. Finally, they can also modulate inflammation and enhance mucosal barrier function (Whelan and Quigley 2013). Use of probiotics in patients affected by IBS has been investigated by several Authors (Moayyedi et al. 2010)(Kajander et al. 2005)(Kim et al. 2003)(Brigidi et al. 2001)(Brenner et al. 2009)(Whorwell et al. 2006), with encouraging results. A recent systematic review on the management of IBS by the Task Force on the Management of Functional Bowel Disorders of the American College of Gastroenterology (Ford, Moayyedi, et al. 2014) concluded that probiotics are effective in reducing IBS symptoms, bloating, and flatulence. In the same review, no recommendations were made regarding the use of prebiotics and symbiotics, due to the low number of trials available (2 for a total of 198 patients). Lactobacillus plantarum (L. plantarum v299) has been tested in a recent clinical trial in patients affected by IBS; a four week treatment provided effective symptoms relief, with particular efficacy on bloating and abdominal pain (Ducrotté, Sawant, and Jayanthi 2012). In the context of the same disease, Lactobacillus acidophilus (L. acidophilus SDC 2012, 2013) was associated with reduced scores for abdominal pain and discomfort after a four week treatment (Sinn et al. 2008). At least two clinical trials assessed the efficacy of Bifidobacterium lactis in the management of IBS. In the first trial, B. lactis DN was demonstrated to improve symptoms and gastrointestinal transit in 34 patients who were treated for four weeks (Agrawal et al. 2009). In the second trial, a B. lactis-enriched yoghurt, consumed twice daily for 8 weeks, was shown to improve symptoms in a group of 130 patients (Min et al. 2012). In this observational study, a four-week dietary supplementation of SynGut TM multi-strain symbiotic, composed of Bifidobacterium lactis W51, Lactobacillus acidophilus W22, Lactobacillus plantarum W21, Lactococcus lactis W19 and inulin, has been associated with an improvement of symptoms, with respect to the baseline, in 71 of the 96 adult IBS patients (Figure 1). Of these, 19 reported a substantial improvement, while 52 reported a partial improvement. Twenty-three 54

7 patients reported no improvement, while only 2 patients discontinued therapy after a few days because of a worsening of IBS symptoms (mainly constipation). No serious adverse effects were reported. Faecal calprotectin dosage was performed to assess gut inflammation in a subgroup of the patients. In these subjects, faecal calprotectin was significantly decreased after two months of SynGut TM supplementation with respect to the baseline (Figure 2). Our data, obtained from an observational study of 96 adult patients, confirms that the multi-strain symbiotic, composed of Bifidobacterium lactis W51, Lactobacillus acidophilus W22, Lactobacillus plantarum W21, Lactococcus lactis W19 and inulin, is well tolerated and supports the hypothesis that this symbiotic improves IBS symptoms. An increase of dosage or duration of the supplementation could be taken into account, at least for those patients who reported a partial improvement of symptoms with the standard dosage of one sachet/day for two months. As far as we known, possible explanation for the group of 23 patients who did not report any significant improvement of symptoms rely on the fact that IBS is multifactorial syndrome and that changes in the microbiota are just one of the involved pathogenic mechanisms. The main limitations for this study include observational design without a control group and the lack of a standardized tool and/or scoring system for subjective evaluation of symptoms. Further studies and randomized trials with larger patient populations are needed to confirm this positive effect with particular focus on strain-specific outcomes, usefulness of concomitant prebiotic and probiotic supplementation, dose optimization, and other relevant manufacturing specifications. Conflict of Interests Filippo Fassio is a medical consultant for Allergy Therapeutics Italia s.r.l; Renato Rossi received consultancy fees from Allergy Therapeutics Italia s.r.l. References Agrawal, A. et al "Clinical Trial: The Effects of a Fermented Milk Product Containing Bifidobacterium Lactis DN on Abdominal Distension and Gastrointestinal Transit in Irritable Bowel Syndrome with Constipation." Alimentary pharmacology & therapeutics 29(1): Astegiano, M. et al "2008 Clinical Approach to Irritable Bowel Syndrome." Minerva gastroenterologica e dietologica 54(3): Barbara, Giovanni et al "Activated Mast Cells in Proximity to Colonic Nerves Correlate with Abdominal Pain in Irritable Bowel Syndrome." Gastroenterology 126: Brenner, Darren M., Matthew J. Moeller, William D. Chey, and Philip S. Schoenfeld "The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review." The American journal of gastroenterology 104(May 2008): ; quiz

8 Brigidi, Patrizia, Beatrice Vitali, Erwin Swennen, Gabriele Bazzocchi, and Diego Matteuzzi "Effects of Probiotic Administration upon the Composition and Enzymatic Activity of Human Fecal Microbiota in Patients with Irritable Bowel Syndrome or Functional Diarrhea." Research in Microbiology 152: Claesson, Marcus J. et al "Composition, Variability, and Temporal Stability of the Intestinal Microbiota of the Elderly." Proceedings of the National Academy of Sciences of the United States of America 108 Suppl : Däbritz, Jan, Jason Musci, and Dirk Foell "Diagnostic Utility of Faecal Biomarkers in Patients with Irritable Bowel Syndrome." World journal of gastroenterology : WJG 20(2): Ducrotté, Philippe, Prabha Sawant, and Venkataraman Jayanthi "Clinical Trial: Lactobacillus Plantarum 299v (DSM 9843) Improves Symptoms of Irritable Bowel Syndrome." World journal of gastroenterology : WJG 18(30): Ford, Alexander C., Paul Moayyedi, et al "American College of Gastroenterology Monograph on the Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation." The American Journal of Gastroenterology 109(S1):S Ford, Alexander C., Eamonn M. M. Quigley, et al "Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-Analysis." The American journal of gastroenterology (April): Ford, Alexander C. and Nicholas J. Talley "Irritable Bowel Syndrome." BMJ 345(September): Guandalini, S., E. Cernat, and D. Moscoso "Prebiotics and Probiotics in Irritable Bowel Syndrome and Inflammatory Bowel Disease in Children." Beneficial microbes Kajander, K., K. Hatakka, T. Poussa, M. Färkkilä, and R. Korpela "A Probiotic Mixture Alleviates Symptoms in Irritable Bowel Syndrome Patients: A Controlled 6-Month Intervention." Alimentary pharmacology & therapeutics 22(5): Kim, H. J. et al "A Randomized Controlled Trial of a Probiotic, VSL#3, on Gut Transit and Symptoms in Diarrhoea-Predominant Irritable Bowel Syndrome." Alimentary pharmacology & therapeutics 17(7): Longstreth, George F. et al "Functional Bowel Disorders." Gastroenterology 130: Lovell, Rebecca M. and Alexander C. Ford "Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-Analysis." Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 10(7): e4. Manzotti, Giuseppina, Enrico Heffler, and Filippo Fassio "Multi-Strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis." Journal of Contemporary Immunology 1(2): Manzotti, Giuseppina, Enrico Heffler, Filippo Fassio, and on behalf of the PANATAD Study Group "Probiotics as a Novel Adjuvant Approach to Atopic Dermatitis." J Contemp Immunol 1(2):

9 Mayer, E. A., M. Craske, and B. D. Naliboff "Depression, Anxiety, and the Gastrointestinal System." The Journal of clinical psychiatry 62 Suppl 8:28 36; discussion 37. Mayer, Emeran A. and J. W. Paulley "Clinical Practice. Irritable Bowel Syndrome." The New England journal of medicine 358(16): Meltzer, Eli O. et al "Rhinosinusitis: Establishing Definitions for Clinical Research and Patient Care." The Journal of allergy and clinical immunology 114(6 Suppl): Min, Yang Won et al "Effect of Composite Yogurt Enriched with Acacia Fiber and Bifidobacterium Lactis." World journal of gastroenterology : WJG 18(33): Mitsuyama, Keiichi and Michio Sata "Gut Microflora: A New Target for Therapeutic Approaches in Inflammatory Bowel Disease." Expert opinion on therapeutic targets 12(3): Moayyedi, P. et al "The Efficacy of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review." Gut 59: O'Mahony, Liam et al "Lactobacillus and Bifidobacterium in Irritable Bowel Syndrome: Symptom Responses and Relationship to Cytokine Profiles." Gastroenterology 128: Rousseaux, Christel et al "Lactobacillus Acidophilus Modulates Intestinal Pain and Induces Opioid and Cannabinoid Receptors." Nature medicine 13(1): Sanders, Mary Ellen et al "An Update on the Use and Investigation of Probiotics in Health and Disease." Gut 62(5): Schwille-Kiuntke, J., J. S. Frick, P. Zanger, and P. Enck "Post-Infectious Irritable Bowel Syndrome--a Review of the Literature." Zeitschrift für Gastroenterologie 49(8): Seksik, Philippe, Xavier Dray, Harry Sokol, and Philippe Marteau "Is There Any Place for Alimentary Probiotics, Prebiotics or Synbiotics, for Patients with Inflammatory Bowel Disease?" Molecular nutrition & food research 52(8): Shanahan, Fergus "The Colonic Microbiota in Health and Disease." Current opinion in gastroenterology 29(1): Sinn, Dong Hyun et al "Therapeutic Effect of Lactobacillus Acidophilus-SDC 2012, 2013 in Patients with Irritable Bowel Syndrome." Digestive diseases and sciences 53(10): Spiller, RC et al "Increased Rectal Mucosal Enteroendocrine Cells, T Lymphocytes, and Increased Gut Permeability Following Acute Campylobacter Enteritis and in Post-Dysenteric Irritable Bowel Syndrome." Gut 47(6): Spiller, Robin C "Role of Infection in Irritable Bowel Syndrome." Journal of Gastroenterology 42:

10 Wald, Arnold and David Rakel. "Behavioral and Complementary Approaches for the Treatment of Irritable Bowel Syndrome." Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 23(3): Whelan, Kevin and Eamonn M. M. Quigley "Probiotics in the Management of Irritable Bowel Syndrome and Inflammatory Bowel Disease." Current opinion in gastroenterology 29(2): Whorwell, Peter J. et al "Efficacy of an Encapsulated Probiotic Bifidobacterium Infantis in Women with Irritable Bowel Syndrome." American Journal of Gastroenterology 101(7):

The role of gut microbiome in IBS

The role of gut microbiome in IBS The role of gut microbiome in IBS Chung Owyang, MD H. Marvin Pollard Professor of Internal Medicine Professor of Molecular and Integrative Physiology Chief, Division of Gastroenterology Director, Pollard

More information

Probiotics. Wide spectrum of important health benefits

Probiotics. Wide spectrum of important health benefits Probiotics Part 1: What Are Probiotics? Probiotics are live microorganisms that inhabit the respiratory and gastrointestinal tracts and the skin. They are often referred to as friendly bacteria as they

More information

Clinically proven to quickly relieve symptoms of common gastrointestinal disorders. TERRAGASTRO - Good health starts in the gut

Clinically proven to quickly relieve symptoms of common gastrointestinal disorders. TERRAGASTRO - Good health starts in the gut Clinically proven to quickly relieve symptoms of common gastrointestinal disorders GASTROINTESTINAL DISEASE Referred to as gastrointestinal diseases, they are common disorders which affect the esophagus,

More information

Probiotics in IBS. Dr. Partha Pratim Das Associate Professor Dhaka Medical college

Probiotics in IBS. Dr. Partha Pratim Das Associate Professor Dhaka Medical college Probiotics in IBS Dr. Partha Pratim Das Associate Professor Dhaka Medical college Definitions Probiotics: Live microorganisms that confer a health benefit on the host when administered in adequate amounts.

More information

SIMPOSIO Il microbiota intestinale e la sua modulazione nelle patologie dell asse intestino cervello. Microbiota e IBS.

SIMPOSIO Il microbiota intestinale e la sua modulazione nelle patologie dell asse intestino cervello. Microbiota e IBS. SIMPOSIO Il microbiota intestinale e la sua modulazione nelle patologie dell asse intestino cervello Microbiota e IBS Cesare Cremon Policlinico S. Orsola Malpighi Azienda Ospedaliero - Universitaria di

More information

Irritable Bowel Syndrome Now. George M. Logan, MD Friday, May 5, :35 4:05 PM

Irritable Bowel Syndrome Now. George M. Logan, MD Friday, May 5, :35 4:05 PM Irritable Bowel Syndrome Now George M. Logan, MD Friday, May 5, 2017 3:35 4:05 PM Dr. Logan indicated no potential conflict of interest to this presentation. He does not intend to discuss any unapproved/investigative

More information

Understanding probiotics and health

Understanding probiotics and health Understanding probiotics and health Gemma Laws MSc Student Microbiology and Immunology Department The gut microbiota The name given to the total microbial population living in our intestine Bacteria, fungi,

More information

ROME IV CRITERIA FOR IBS

ROME IV CRITERIA FOR IBS PRACTICAL CONSIDERATIONS IN THE MANAGEMENT OF IBS BRENDA HORWITZ MD PROFESSOR OF CLINICAL MEDICINE LEWIS KATZ SCHOOL OF MEDICINE AND TEMPLE UNIVERSITY HEALTH SCIENCES CENTER OR THINGS I ALWAYS WANTED TO

More information

Probiotics : What we Know and Where we are Going Next

Probiotics : What we Know and Where we are Going Next Probiotics : What we Know and Where we are Going Next Neerja Hajela, Ph.D. General Manager - Science and Regulatory Affairs Yakult Danone India Pvt. Ltd. Functional Food Market Probiotics an important

More information

This is an author produced version of Symbiotics in irritable bowel syndrome - better than probiotics alone?.

This is an author produced version of Symbiotics in irritable bowel syndrome - better than probiotics alone?. This is an author produced version of Symbiotics in irritable bowel syndrome - better than probiotics alone?. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/97333/ Article:

More information

Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial

Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial BOWEL Ahmet Baştürk, Reha Artan, Aygen Yılmaz Department of Pediatric

More information

Formulations and Availability 900 BILLION 5,319 HIGH POTENCY PROBIOTIC PEDIATRIC ADULT GERIATRIC PROVEN BY RESEARCH. HIGH-POTENCY. NO SHORTCUTS.

Formulations and Availability 900 BILLION 5,319 HIGH POTENCY PROBIOTIC PEDIATRIC ADULT GERIATRIC PROVEN BY RESEARCH. HIGH-POTENCY. NO SHORTCUTS. Formulations and Availability S TU D I E S PE R D I S E A S E 39 LIVER Liver Disease, Cirrhosis, Liver Failure, Hepatic Encephalopathy S TU D I E S PE R AG E G RO U P Visbiome Regular Product Code: 693-0412-01

More information

PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND)

PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND) PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT Karen Jensen, (Retired ND) Today many people are aware of the benefits of maintaining a healthy gut. As a result, probiotic use is becoming ever more popular.

More information

Modulation of abdominal pain by probiotics. Anna Lyra, PhD DuPont Nutrition & Health

Modulation of abdominal pain by probiotics. Anna Lyra, PhD DuPont Nutrition & Health Modulation of abdominal pain by probiotics Anna Lyra, PhD DuPont Nutrition & Health Functional gastrointestinal (GI) wellbeing Up to 70% suffer from functional GI symptoms - ¾ do not seek medical care

More information

The role of nutrition in optimum gastrointestinal health

The role of nutrition in optimum gastrointestinal health The role of nutrition in optimum gastrointestinal health Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor University Distinguished Teacher-Scholar University of Illinois

More information

Ever wonder what s really happening on the inside?

Ever wonder what s really happening on the inside? For Practitioners Ever wonder what s really happening on the inside? Are your patients suffering from diarrhea, constipation, bloating, gas or indigestion? Rocky Mountain Analytical is now offering Gut-Well

More information

Microbiome GI Disorders

Microbiome GI Disorders Microbiome GI Disorders Prof. Ram Dickman Neurogastroenterology Unit Rabin Medical Center Israel 1 Key Points Our gut microbiota Were to find them? Symbiosis or Why do we need them? Dysbiosis or when things

More information

Xifaxan, Lotronex and Viberzi Prior Authorization and Quantity Limit Program Summary

Xifaxan, Lotronex and Viberzi Prior Authorization and Quantity Limit Program Summary Xifaxan, Lotronex and Viberzi Prior Authorization and Quantity Limit Program Summary FDA APPROVED INDICATIONS DOSAGE 1,2 Lotronex (alosetron) a Indication For women with severe diarrheapredominant irritable

More information

ROLE OF THE GUT BACTERIA

ROLE OF THE GUT BACTERIA ROLE OF THE GUT BACTERIA Our Good Bacteria In a perfect world, we would all have a proper ratio of good bacteria And what could this proper ratio do for us? The knowledge of the connections between our

More information

The Role of Food in the Functional Gastrointestinal Disorders

The Role of Food in the Functional Gastrointestinal Disorders The Role of Food in the Functional Gastrointestinal Disorders H. Vahedi, MD. Gastroentrologist Associate professor of medicine DDRI 92.4.27 vahedi@ams.ac.ir Disorder Sub-category A. Oesophageal disorders

More information

Gut microbiota in IBS and its modification by diet: probiotics, prebiotics and low FODMAP diet

Gut microbiota in IBS and its modification by diet: probiotics, prebiotics and low FODMAP diet Gut microbiota in IBS and its modification by diet: probiotics, prebiotics and low FODMAP diet Kevin Whelan PhD RD FBDA Professor of Dietetics Department of Nutritional Sciences King s College London Nutritional

More information

Bio Pro 365. Product Summary. Ingredients. Prebiotic Probiotic Blend. Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend

Bio Pro 365. Product Summary. Ingredients. Prebiotic Probiotic Blend. Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend Bio Pro 365 Prebiotic Probiotic Blend Product Summary Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend specifically designed to protect and enhance all aspects of the digestion

More information

Unlocking the mysteries of gut comfort

Unlocking the mysteries of gut comfort Priority Research Programme Foods for improving gut function and comfort Unlocking the mysteries of gut comfort Nicole Roy, Professor AgResearch and Riddet Institute Host institution Foods for gut function

More information

A Randomized Open Label Comparative Clinical Study of a Probiotic against a Symbiotic in the Treatment of Acute Diarrhoea in Children

A Randomized Open Label Comparative Clinical Study of a Probiotic against a Symbiotic in the Treatment of Acute Diarrhoea in Children International Journal of Medical Research & Health Sciences Available online at www.ijmrhs.com ISSN No: 2319-5886 International Journal of Medical Research & Health Sciences, 2017, 6(9): 96-100 I J M R

More information

Irritable Bowel Syndrome. Mustafa Giaffer March 2017

Irritable Bowel Syndrome. Mustafa Giaffer March 2017 Irritable Bowel Syndrome Mustafa Giaffer March 2017 Introduction First described in 1771. 50% of patients present

More information

IBS - Definition. Chronic functional disorder of GI generally characterized by:

IBS - Definition. Chronic functional disorder of GI generally characterized by: IBS - Definition Chronic functional disorder of GI generally characterized by: 3500 3000 No. of Publications 2500 2000 1500 1000 Irritable Bowel syndrome Irritable Bowel Syndrome 500 0 1968-1977 1978-1987

More information

The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 22 June 2011

The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 22 June 2011 The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 22 June 2011 SPASFON, film-coated tablets B/30 (CIP code: 309 860-8) SPASFON, suppositories B/10 (CIP code: 309 861-4)

More information

Gut Microbiota and IBD. Vahedi. H M.D Associate Professor of Medicine DDRI

Gut Microbiota and IBD. Vahedi. H M.D Associate Professor of Medicine DDRI Gut Microbiota and IBD Vahedi. H M.D Associate Professor of Medicine DDRI 1393.3.1 2 GUT MICROBIOTA 100 Trillion Microbes - 10 times more than cells in our body Collective weight of about 1kg in human

More information

Mashhad University of Medical Sciences. Azita Ganji MD, MPH

Mashhad University of Medical Sciences. Azita Ganji MD, MPH Mashhad University of Medical Sciences Azita Ganji MD, MPH 30.2.95 CD Food sensitivity (NCGS, ) Food intolerance IBS Gluten translocate through the epithelial mucosa via increased tight junction (TJ)

More information

PROSPERO International prospective register of systematic reviews

PROSPERO International prospective register of systematic reviews PROSPERO International prospective register of systematic reviews The effect of probiotics on functional constipation: a systematic review of randomised controlled trials EIRINI DIMIDI, STEPHANOS CHRISTODOULIDES,

More information

The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 6 April 2011

The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 6 April 2011 The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 6 April 2011 METEOXANE, capsules B/60 (CIP code: 306 693-3) Applicant: IPRAD Simethicone Hydrated phloroglucinol ATC

More information

The long-term impact of the low-fodmap diet for management of irritable bowel syndrome. Dr Miranda Lomer RD.

The long-term impact of the low-fodmap diet for management of irritable bowel syndrome. Dr Miranda Lomer RD. The long-term impact of the low-fodmap diet for management of irritable bowel syndrome Dr Miranda Lomer RD Email: miranda.lomer@kcl.ac.uk What is IBS - ROME IV Criteria A functional bowel disorder in which

More information

ESPEN Congress Vienna Networking with your microbiota Specific evidence-based indications. H. Lochs (Germany)

ESPEN Congress Vienna Networking with your microbiota Specific evidence-based indications. H. Lochs (Germany) ESPEN Congress Vienna 2009 Networking with your microbiota Specific evidence-based indications H. Lochs (Germany) Probiotics Evidence based indications H. Lochs Medizinische Klinik mit Schwerpunkt Gastroenterologie,

More information

Dietitian Connection Webinar: Dietary management of IBS the low FODMAP diet & other adjunct therapies. Presented by Shirley Webber and Dr Jane Varney

Dietitian Connection Webinar: Dietary management of IBS the low FODMAP diet & other adjunct therapies. Presented by Shirley Webber and Dr Jane Varney Dietitian Connection Webinar: Dietary management of IBS the low FODMAP diet & other adjunct therapies Presented by Shirley Webber and Dr Jane Varney Q. When doing the challenges, does the patient have

More information

Diagnosis and Management of Irritable Bowel Syndrome (IBS) For the Primary Care Provider

Diagnosis and Management of Irritable Bowel Syndrome (IBS) For the Primary Care Provider Diagnosis and Management of Irritable Bowel Syndrome (IBS) For the Primary Care Provider Elizabeth Coss, MD General Gastroenterologist Audie Murphy Veterans Hospital UT Health This presentation does not

More information

Alimentary Pharmacology and Therapeutics SUMMARY

Alimentary Pharmacology and Therapeutics SUMMARY Alimentary Pharmacology and Therapeutics Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life a double-blind, placebo-controlled

More information

Probiotics. Gastrointestinal Health & Disease. in conjunction with American College of Gastroenterology Annual Scientific Meeting

Probiotics. Gastrointestinal Health & Disease. in conjunction with American College of Gastroenterology Annual Scientific Meeting X E C U E T I V E P R O C E E D I N G S Symposium in conjunction with American College of Gastroenterology Annual Scientific Meeting Probiotics Applications in Gastrointestinal Health & Disease Made Possible

More information

Q What are Probiotics?

Q What are Probiotics? Q What are Probiotics? The word PROBIOTIC was originated from Latin and means For Life. Probiotics are good bacteria usually found in food products or supplements which play very important roles in regulating

More information

השפעת חיידקים פרוביוטיים

השפעת חיידקים פרוביוטיים השפעת חיידקים פרוביוטיים החיים בחלל )המעי(... על רון שאול יחידת גסטרו ילדים מרכז רפואי רמב"ם Introduction The intestinal microflora primarily in the large bowel consists mostly on benign bacterial species

More information

Unlocking the mysteries of gut comfort

Unlocking the mysteries of gut comfort Priority Research Programme Foods for improving gut function and comfort Unlocking the mysteries of gut comfort Nicole Roy, Professor AgResearch and Riddet Institute Host institution Foods for gut function

More information

WEBINAR Microbial Metabolism Associated with Health. 12 April 2018; CET

WEBINAR Microbial Metabolism Associated with Health. 12 April 2018; CET WEBINAR Microbial Metabolism Associated with Health 12 April 2018; 15.00-16.30 CET PROGRAMME Brief Introduction of Both Organisations and Scientific Background Dr Bettina Schelkle (ILSI Europe, BE) Dr

More information

NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd.

NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd. NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd. What we already know. Functional Foods - foods that provide a health benefit beyond the traditional nutrients it contains.. American Dietetics

More information

... SELECTED ABSTRACTS...

... SELECTED ABSTRACTS... ... SELECTED ABSTRACTS... The following abstracts, from medical journals containing literature on irritable bowel syndrome, were selected for their relevance to this supplement. A Technical Review for

More information

Presenter. Irritable Bowel Syndrome. Objectives. Introduction. Rome Criteria. Irritable Bowel Syndrome 2/28/2018

Presenter. Irritable Bowel Syndrome. Objectives. Introduction. Rome Criteria. Irritable Bowel Syndrome 2/28/2018 Presenter Irritable Bowel Syndrome Current evidence for diagnosis & management Julie Daniels DNP, CNM Assistant Professor Course Coordinator of Primary Care of Women Faculty at Frontier Nursing University

More information

JMSCR Vol 05 Issue 11 Page November 2017

JMSCR Vol 05 Issue 11 Page November 2017 www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 71.58 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i11.139 The Effect of Synbiotics on the Duration

More information

The Gut Microbiome: 101 Justin Carlson University of Minnesota

The Gut Microbiome: 101 Justin Carlson University of Minnesota The Gut Microbiome: 101 Justin Carlson University of Minnesota Where are we now? 360 B.C. 2003 Human Gut Microbes Associated With Obesity Ley et al., Nature. 2006. Consumer Driven Science For Better of

More information

ULTIMATE FLORA PROBIOTICS

ULTIMATE FLORA PROBIOTICS ULTIMATE FLORA PROBIOTICS In the Refrigerator Section! High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion*

More information

PROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora.

PROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora. PROBIONA Probiotic supplement for adults PROBIOTICS with 5 bacterial strains Suitable during and after the use of antibiotics to restore intestinal microflora. 2.850 billion cfu per capsule guaranteed

More information

Clinical Report: Probiotics and Prebiotics in Pediatrics

Clinical Report: Probiotics and Prebiotics in Pediatrics www.medscape.com Authors and Disclosures Author(s) Dan W. Thomas, MD Professor of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California; Head, Division of Gastroenterology

More information

INTRODUCING YOUR GUT BACTERIA

INTRODUCING YOUR GUT BACTERIA INTRODUCING YOUR GUT BACTERIA Microflora Intestinal flora 1.5 kg We would die with 5 years of birth if we did not have them as we would not develop a proper immune system 1000 species and 5000 strains

More information

2/3/2011. Adhesion of Bifidobacterium lactis HN019 to human intestinal

2/3/2011. Adhesion of Bifidobacterium lactis HN019 to human intestinal PROBIOTICS LEARNING THE WHY AND WHEN PROBIOTICS DEFINITION live micro-organisms organisms that are beneficial to the host organism WHO: Live organisms which, when administered in adequate amounts, confer

More information

Dietary fiber is defend as the edible parts of plant or analogous carbohydrates

Dietary fiber is defend as the edible parts of plant or analogous carbohydrates Chengcheng Jia NUTR 417 Supplement Paper The Soluble Dietary Fiber: Inulin Introduction and Supplement Background: Dietary fiber is defend as the edible parts of plant or analogous carbohydrates that are

More information

CHAPTER 11 Functional Gastrointestinal Disorders (FGID) Mr. Ashok Kumar Dept of Pharmacy Practice SRM College of Pharmacy SRM University

CHAPTER 11 Functional Gastrointestinal Disorders (FGID) Mr. Ashok Kumar Dept of Pharmacy Practice SRM College of Pharmacy SRM University CHAPTER 11 Functional Gastrointestinal Disorders (FGID) Mr. Ashok Kumar Dept of Pharmacy Practice SRM College of Pharmacy SRM University 1 Definition of FGID Chronic and recurrent symptoms of the gastrointestinal

More information

Quick Guide to Probiotics for Digestive Health

Quick Guide to Probiotics for Digestive Health Quick Guide to Probiotics for Digestive Health The following are some commercially available probiotic single-strain or multi-strain products with evidence from human clinical trials (see references) for

More information

GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH?

GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH? GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH? Corrie Whisner, PhD School of Nutrition and Health Promotion Arizona State University Center for Research on Ingredient Safety Annual Meeting

More information

Disorders in which symptoms cannot be explained by the presence of structural or tissue abnormalities Irritable bowel syndrome Functional heartburn Functional dyspepsia Functional constipation Functional

More information

9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives

9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives The Physiological Roles of the Intestinal Microbiota Kelly A. Tappenden, Ph.D., R.D., FASPEN Professor and Head, Kinesiology and Nutrition University Distinguished Teacher-Scholar University of Illinois

More information

Fecal microbiota transplantation: The When,the How and the Don t. By Dr Rola Hussein

Fecal microbiota transplantation: The When,the How and the Don t. By Dr Rola Hussein Fecal microbiota transplantation: The When,the How and the Don t By Dr Rola Hussein Introduction Fecal microbiota transplantation (FMT) involves administration of fecal material containing distal gut microbiota

More information

THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME?

THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME? THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME? ALTERNATIVEMEDICINE.COM SUBCONSCIOUS SUGGESTION: WE TRY HYPNOTHERAPY The Color Run: 5 TIPS TO BEAT THE BUGS HORSES THAT

More information

What Are Probiotics? PROBIOTICS

What Are Probiotics? PROBIOTICS PROBIOTICS What Are Probiotics? Probiotics are living, microscopic (very small) organisms that can help your gut health. Most often, probiotics are bacteria, but they may also be other organisms, such

More information

11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic?

11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic? A Consumer s Guide to Probiotics and Health Wellness Wednesday November 2, 2016 Wendy Dahl RD PhD FDC Associate Professor, Food Science and Human Nutrition, UF/IFAS Objectives To outline current evidence

More information

Breaking New Research on the Effects of Symbiotic Fermented Soy and Inflammatory Bowel Disease (IBD) September 2018

Breaking New Research on the Effects of Symbiotic Fermented Soy and Inflammatory Bowel Disease (IBD) September 2018 Breaking New Research on the Effects of Symbiotic Fermented Soy and Inflammatory Bowel Disease (IBD) September 2018 Digestive Health System of the body known for silent diseases Conditions are mostly asymptomatic

More information

Fonterra Probiotics: From guts to glory

Fonterra Probiotics: From guts to glory Fonterra Probiotics: From guts to glory James Dekker April 16, 2015 Host Institution Probiotic bacteria Live micro-organisms which, when administered in adequate amounts, confer a health benefit on the

More information

Gut Lung Axis Implication of the Gut Microbiota beyond its niche

Gut Lung Axis Implication of the Gut Microbiota beyond its niche Gut Lung Axis Implication of the Gut Microbiota beyond its niche Reema Subramanian PhD Candidate (4 th year) Supervisor: Prof. Margaret Ip Department of Microbiology, CUHK Joint Graduate Student Seminar

More information

!Microbiology Profile, stool

!Microbiology Profile, stool LAB #: F000000-0000-0 PATIENT: Sample Patient ID: P12345 SEX: Female AGE: 37 CLIENT #: 12345 DOCTOR: Doctor's Data, Inc. 3755 Illinois Ave. St. Charles, IL 60174!Microbiology Profile, stool BACTERIOLOGY

More information

VITAMINS, MINERALS AND THE GUT

VITAMINS, MINERALS AND THE GUT VITAMINS, MINERALS AND THE GUT Nutrients Looking at individual nutrients that are involved with gut health can be misleading This is not about taking individual nutrients It supports more a whole food

More information

Irritable bowel syndrome (IBS) and chronic idiopathic constipation

Irritable bowel syndrome (IBS) and chronic idiopathic constipation CLINICAL AND SYSTEMATIC S nature publishing group 1547 see related editorial on page 1563 CME Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation:

More information

Probiotics. NOW Guide to Probiotics

Probiotics. NOW Guide to Probiotics Probiotics NOW Guide to Probiotics The Health Benefits of Probiotics Microorganisms for Health Did you know that you have trillions of microorganisms, including bacteria and yeast, living in and on your

More information

David Leff, DO. April 13, Disclosure. I have the following financial relationships to disclosure:

David Leff, DO. April 13, Disclosure. I have the following financial relationships to disclosure: David Leff, DO AOMA 94 th Annual Convention April 13, 2016 Disclosure I have the following financial relationships to disclosure: Speaker s Bureau: Allergan Labs, Takeda Pharmaceutical, Valeant Pharmaceutical

More information

Study summaries L. casei 431

Study summaries L. casei 431 This binder provides you with summaries of selected publications on Lactobacillus paracasei subsp. paracasei L. casei 431. The publications are clinical studies performed in humans documenting the effects

More information

PROBIOTICS. The Ultimate Flora Difference

PROBIOTICS. The Ultimate Flora Difference In the Refrigerator Section! PROBIOTICS High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion * The ReNew Life

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Fecal Analysis in the Diagnosis of Intestinal Dysbiosis File Name: Origination: Last CAP Review: Next CAP Review: Last Review: fecal_analysis_for_intestinal_dysbiosis 5/2001 5/2018

More information

The effect of probiotics on animal health: a focus on host s natural intestinal defenses

The effect of probiotics on animal health: a focus on host s natural intestinal defenses The effect of probiotics on animal health: a focus on host s natural intestinal defenses Guillaume Tabouret Animal Health Dept. Joint Unit 1225 Host Pathogens Interactions History of probiotics and definition

More information

Lavanya Nutankalva,MD Consultant: Infectious Diseases

Lavanya Nutankalva,MD Consultant: Infectious Diseases Lavanya Nutankalva,MD Consultant: Infectious Diseases Introduction The word Probiotic was derived from the Greek phrase meaning for life." was first coined in the 1960s by Lilly and Stillwell. Probiotics

More information

Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis

Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis Online Submissions: http://www.wjgnet.com/esps/ wjg@wjgnet.com doi:10.3748/wjg.v18.i33.4563 World J Gastroenterol 2012 September 7; 18(33): 4563-4569 ISSN 1007-9327 (print) ISSN 2219-2840 (online) 2012

More information

Manipulating the gut microbiome

Manipulating the gut microbiome Manipulating the gut microbiome William DePaolo, PhD Associate Professor Medicine Director Center for Microbiome Sciences & Therapeutics University of Washington Microbiota The actual bugs that reside

More information

Bringing Synbiotic Interventions in Cancer to Practice: from bench to bedside The UC Davis Foods for Health Institute

Bringing Synbiotic Interventions in Cancer to Practice: from bench to bedside The UC Davis Foods for Health Institute Bringing Synbiotic Interventions in Cancer to Practice: from bench to bedside The UC Davis Foods for Health Institute Jennifer T. Smilowitz, PhD Associate Director, Human Studies Research jensm@ucdavis.edu

More information

PRE AND PROBIOTICS PRACTICAL APPLICATIONS FOR VNS IN PRACTICE

PRE AND PROBIOTICS PRACTICAL APPLICATIONS FOR VNS IN PRACTICE Vet Times The website for the veterinary profession https://www.vettimes.co.uk PRE AND PROBIOTICS PRACTICAL APPLICATIONS FOR VNS IN PRACTICE Author : Linda Matthewman, Karin Allenspach Categories : RVNs

More information

Chronic Abdominal Pain. Dr. Robert B. Smith Tupelo Digestive Health Specialists August 26, 2016

Chronic Abdominal Pain. Dr. Robert B. Smith Tupelo Digestive Health Specialists August 26, 2016 Chronic Abdominal Pain Dr. Robert B. Smith Tupelo Digestive Health Specialists August 26, 2016 Disclosures Speaker Bureau for Allergan Pharmaceuticals Abdominal Pain - Definitions Acute occurring for several

More information

COMPLETE DIGESTIVE STOOL ANALYSIS - (CDSA) Level 4

COMPLETE DIGESTIVE STOOL ANALYSIS - (CDSA) Level 4 Macroscopic Appearance Colour Brown Consistency Semi-formed Fibres 0-2 Food Remnants 0-2 2 3 Brown Formed Microscopic Appearance Starch Cells 0 0Ref 0 Fat Globules 0 0 0 Meat Fibres 0 Ref Vegetable Fibres

More information

Structure/Function Claims for Soil-Based Organisms Manufactured by Life Science Products, Inc., Houston, Texas

Structure/Function Claims for Soil-Based Organisms Manufactured by Life Science Products, Inc., Houston, Texas Structure/Function Claims for Soil-Based Organisms Manufactured by Life Science Products, Inc., Houston, Texas Consumer Summary Soil-Based Organism (SBOs ) products consist of a mixture of eight (8) species

More information

Does The Use Of Probiotics Treat Abdominal Pain In Children Between The Ages Of 4 And 18 With Irritable Bowel Syndrome?

Does The Use Of Probiotics Treat Abdominal Pain In Children Between The Ages Of 4 And 18 With Irritable Bowel Syndrome? Philadelphia College of Osteopathic Medicine DigitalCommons@PCOM PCOM Physician Assistant Studies Student Scholarship Student Dissertations, Theses and Papers 2018 Does The Use Of Probiotics Treat Abdominal

More information

What GI Physicians Need to Know About Probiotics

What GI Physicians Need to Know About Probiotics Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/gi-insights/what-gi-physicians-need-to-know-about-probiotics/3844/

More information

Is one of the most common chronic disorders. causing patients to seek medical treatment.

Is one of the most common chronic disorders. causing patients to seek medical treatment. ILOs After this lecture you should be able to : Define IBS Identify causes and risk factors of IBS Determine the appropriate therapeutic options for IBS Is one of the most common chronic disorders causing

More information

Mark Manary MD. International Symposium on Understanding Moderate Malnutrition in Children for Effective Interventions

Mark Manary MD. International Symposium on Understanding Moderate Malnutrition in Children for Effective Interventions Possible role of the microbiome in the development of acute malnutrition and implications for food-based strategies to prevent and treat acute malnutrition International Symposium on Understanding Moderate

More information

Presented by Megan R. Sanctuary, MS University of California at Davis

Presented by Megan R. Sanctuary, MS University of California at Davis Effects of supplementation with Bifidobacterium infantis in combination with bioactive milk components on gastrointestinal symptoms in children with autism Presented by Megan R. Sanctuary, MS University

More information

Tenapanor for irritable bowel syndrome with constipation

Tenapanor for irritable bowel syndrome with constipation NIHR Innovation Observatory Evidence Briefing: February 2018 Tenapanor for irritable bowel syndrome with constipation NIHRIO (HSRIC) ID: 6704 NICE ID: 9736 LAY SUMMARY Irritable bowel syndrome with constipation

More information

LET S TALK BUGS! THE ROLE OF PROBIOTICS IN PATIENT HEALTH AND DISEASE PREVENTION. Dragana Skokovic-Sunjic RPh BScPhm NCMP

LET S TALK BUGS! THE ROLE OF PROBIOTICS IN PATIENT HEALTH AND DISEASE PREVENTION. Dragana Skokovic-Sunjic RPh BScPhm NCMP LET S TALK BUGS! THE ROLE OF PROBIOTICS IN PATIENT HEALTH AND DISEASE PREVENTION Dragana Skokovic-Sunjic RPh BScPhm NCMP OUTLINE After the presentation, pharmacists will be able to: 1. Review and discuss

More information

Bloating, Flatulence, and

Bloating, Flatulence, and A 45-Year-Old Man With Recurrent Abdominal Pain, Bloating, Flatulence, and Intermittent Loose Stools Anthony J. Lembo, MD Associate Professor of Medicine Harvard Medical School Director, GI Motility Laboratory

More information

PELVIC PAIN : Gastroenterological Conditions

PELVIC PAIN : Gastroenterological Conditions PELVIC PAIN : Gastroenterological Conditions Departman Tarih Prof. A. Melih OZEL, MD Department of Gastroenterology Anadolu Medical Center Hospital Gebze Kocaeli - TURKEY Presentation plan 15 min. Introduction

More information

Mastertitelformat bearbeiten. consulting & clinical research

Mastertitelformat bearbeiten. consulting & clinical research Mastertitelformat bearbeiten consulting & clinical research a&r Mastertitelformat bearbeiten Examining the impact of changing regulatory environment on the digestive health market Food Matters Live 2015,

More information

Nicholas J. Talley, MD University of Newcastle Callaghan, NSW Australia. Mark Pimentel, MD Cedars-Sinai Medical Center Los Angeles, CA

Nicholas J. Talley, MD University of Newcastle Callaghan, NSW Australia. Mark Pimentel, MD Cedars-Sinai Medical Center Los Angeles, CA Lin Chang, MD David Geffen School of Medicine at UCLA Los Angeles, CA Mark Pimentel, MD Cedars-Sinai Medical Center Los Angeles, CA Nicholas J. Talley, MD University of Newcastle Callaghan, NSW Australia

More information

Do Probiotics Provide Adequate Relief From Overall Symptoms, Including Abdominal Pain and Bloating, in Adults With Irritable Bowel Syndrome?

Do Probiotics Provide Adequate Relief From Overall Symptoms, Including Abdominal Pain and Bloating, in Adults With Irritable Bowel Syndrome? Philadelphia College of Osteopathic Medicine DigitalCommons@PCOM PCOM Physician Assistant Studies Student Scholarship Student Dissertations, Theses and Papers 2015 Do Probiotics Provide Adequate Relief

More information

Resistant Starch for a Healthy Gut

Resistant Starch for a Healthy Gut Resistant Starch for a Healthy Gut Experience Life Resistant Starch for a Healthy Gut Heather Rogers March 2016 Long underappreciated, resistant starch is a friendly carb component that delivers healthy

More information

Bacteriology. Mycology. Patient: SAMPLE PATIENT DOB: Sex: MRN: Rare. Rare. Positive. Brown. Negative *NG. Negative

Bacteriology. Mycology. Patient: SAMPLE PATIENT DOB: Sex: MRN: Rare. Rare. Positive. Brown. Negative *NG. Negative Patient: SAMPLE PATIENT DOB: Sex: MRN: 3.2 0.9-26.8 U/g 1.2 0.2-3.3 mg/g 2.2 1.3-8.6 micromol/g 1.1 1.3-23.7 mg/g 1.1 0.2-3.5 mg/g Rare 1.0 0.2-8.8 mg/g Rare 4.4 2.6-32.4 mg/g 64.6 >= 13.6 micromol/g Bacteriology

More information

Increasing barrier function with multispecies probiotics

Increasing barrier function with multispecies probiotics Increasing barrier function with multispecies probiotics Elsbeth Pekelharing, MSc Science Liaison We strive for the most effective microbiome management solutions with our evidence-based & indication-specific

More information

The ImmuneCare Guide to. Gluten Sensitivity

The ImmuneCare Guide to. Gluten Sensitivity The ImmuneCare Guide to Gluten Sensitivity Gluten Sensitivity Introduction Gluten sensitivity, also called non-coeliac gluten sensitivity (NCGS), is a condition related to gluten ingestion that can cause

More information

Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint

Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint Neerja Hajela, PhD General Manager-Science & Regulatory Affairs Yakult Danone India Pvt. Ltd. Outline of the Presentation Global Epidemiology

More information

Spectrum of Diverticular Disease. Outline

Spectrum of Diverticular Disease. Outline Spectrum of Disease ACG Postgraduate Course January 24, 2015 Lisa Strate, MD, MPH Associate Professor of Medicine University of Washington, Seattle, WA Outline Traditional theories and updated perspectives

More information

Complementary & Alternative Therapies in IBD

Complementary & Alternative Therapies in IBD Complementary & Alternative Therapies in IBD Laurie Rosales, APRN-CNP OSU Wexner Medical Center Division of Gastroenterology, Hepatology and Nutrition Complementary & Alternative Probiotics Cannabis Fish

More information