The Role of Surgery in Pancreatic Pseudocyst
|
|
- Giles Gallagher
- 6 years ago
- Views:
Transcription
1 Pncres The Role of Surgery in Pncretic Pseudocyst Wen-Yo Yin, Hw-Tzong Chen 3, Shih-Ming Hung 3, Chih-Wen Lin 1, Shih-Pin Lin, Dh-Wen Shyu, Chng-Kuo Wei, Ming-Che Lee 3, An-Ling Chou 2, Kuo-Chih Tseng 2, Yo-Jen Chng 3 Deprtment of Surgery, 1 Rdiology, nd 2 Medicine, Buddhist Dlin Tzu Chi Generl Hospitl, Chiyi; 3Deprtment of Surgery, Buddhist Tzu Chi Buddhist Generl Hospitl, Hulien, Tiwn Corresponding Author: Dr. Wen-Yo Yin, Deprtment of Surgery, Buddhist Dlin Tzu Chi Generl Hospitl 2, Min Sheng Rod, Dlin, Chiyi, Tiwn Tel: Ext. 5906/5242, Fx: , E-mil: Yowen@mil.tcu.edu.tw Originl Pper ABSTRACT Bckground/Aims: Surgery hs een the only option ville for mny yers for treting pseudocyst of the pncres. Recently, new methods, such s percutneous dringe, endoscopic trnsenteric dringe nd trnsppillry dringe, egn to e used for tretment of the pseudocyst. But we hve to gree tht no single technique offers the desired comintion of 100% success nd no complictions. We'd like to present our surgicl experience in the pst 14 yers. Methodology: A totl of 22 ptients were treted for pncretic pseudocyst (PP) in our deprtments in Dlin nd Hulien Tzu-Chi Generl Hospitl within the lst 14 yers. They were retrospectively reviewed nd followed up until recently. Results: There were 14 (63.6%) mles nd 8 (36.4%) femles ged etween 15 nd 79 yers old (men ge 38.2 yers). Dominting symptoms in most ptients were epigstric pin, plple mss, nuse, vomiting, fever nd leukocytosis, nd persistent elevtion of serum mylse. Imging studies, such s ultrsound, computed tomogrphy (CT) scn, nd endoscopic retrogrde cholngiopncretogrphy (ERCP), were helpful in estlishing dignosis. In ddition to symptomtic persistent lrge (>6cm) pseudocyst, vrious types of compliction including infection, gstrointestinl (GI) ostruction, rupture into GI trct, peritonitis, GI leeding, internl leeding, nd pncretic scites were indictions for surgery in our cses. Opertive procedures composed of externl dringe (ED, 9 cses), internl dringe using cystojejunostomy (CJ, 4 cses) nd cystogstrostomy (CG, 8 cses), nd distl pncretectomy (1 cse). Ten complictions (45.5%) included recurrence of cyst (1 in ED nd 1 in CJ), recurrence with pncreticopleurl fistul (1 in ED), colon perfortion (1 in ED), delyed mssive leeding (1 in CG), pncretic fistul (3 in ED), pncretic scess (1 in CJ) nd persistent pin (1 in CG). Reopertion ws needed for check leeding (1 in CG) nd proximl colostomy for colon injury (1 in ED). A cse received CJ for recurrence of pseudocyst 9 yers lter (1 in CJ). Percutneous dringe with wide ore tue ws effective for pncretic scess (1 in CJ) nd trnsppillry dringe with stent ws used to relieve pleurl effusion with respirtory filure (1 in ED). No mortlity occurred in this series. Conclusions: We elieve tht surgery, though without flws, still plys n importnt role in the mngement of selected cses of pseudocyst of the pncres. Surgicl intervention, endoscopic dringe, nd percutneous dringe were complementry rther thn conflicting lterntives oth for the simple nd complicted pseudocysts. KEY WORDS: Pncretic pseudocyst; Internl dringe; Externl dringe; Percutneous dringe; Trnsppillry dringe ABBREVIATIONS: Pncretic Pseudocyst (PP); Computed Tomogrphy (CT); Endoscopic Retrogrde Cholngiopncretogrphy (ERCP); Externl Dringe (ED); Cystojejunostomy (CJ); Cystogstrostomy (CG); Gstrointestinl (GI); Common Bile Duct (CBD) INTRODUCTION In 1862, Le Dentu (1) proclimed tht cysts of the pncres "should e relegted to the list of ffecttions for which the heling id is impotent". Fortuntely, for the ptient in whom pseudocyst develops s compliction of pncretitis, this prediction hs een proved incorrect. Despite more thn 100 yers of surgicl experience with this disese entity, controversy continues to surround the timing of opertive intervention s well s indictions for specific procedures. Surgery ws the only option ville for mny yers. In the opinions of most surgeons nd mny senior gstroenterologists, surgicl dringe is still the tretment of choice. It hs een minsty for the mngement of the pseudocyst ecuse of recurrent or persistent pseudocyst, presenting s complictions such s rupture of cyst, comintion with common ile Hepto-Gstroenterology 2005; 52: H.G.E. Updte Medicl Pulishing S.A., Athens-Stuttgrt duct (CBD) or duodenl stenosis, ssocition with dilted pncretic duct, nd suspicion of neoplsm. Recently, new methods, such s percutneous dringe, endoscopic cystoenterostomy, nd endoscopic trnsppillry dringe hve een developed to tret the pseudocyst. However it is not widely used for its technicl demnd s well s indequcy of endoscopic internl dringe (10-50% with men of 23% require surgery) (2), nd percutneous dringe (50-60% of ptients treted needed further tretment) (3). But we hve to gree tht no single technique offers the desired comintion of 100% success nd no compliction. We reviewed the results of surgicl therpy for pncretic pseudocysts including vrious complictions t our institutions y the sme surgicl tem over the lst 14 consecutive yers. Only few ppers in this field hve een pulished in this fshion
2 1268 Hepto-Gstroenterology 52 (2005) W-Y Yin, H-T Chen, S-M Hung, et l. FIGURE 1 Both the sonogrphic nd CT were eqully good for dignosis of PP. () Sonogrphic finding of huge pseudocyst. () A ig cyst t the til of pncres in CT scn. FIGURE 2 Sonogrphy ws s good s CT in postopertive followup. () Shrinkge of the cyst seen in sonogrphy. () No definite cyst ws seen ehind the stomch. during lst two decdes (4-7). One of the most importnt resons is tht such cses were not so common in our surgicl prctice. The im of this pper is to shre our surgicl experience with this disese entity with our collegues. METHODOLOGY A totl of 22 ptients treted for pncretic pseudocyst presenting with different mnifesttions in surgicl deprtments oth in Hulien nd Dlin Tzu Chi Generl hospitls in the pst 14 yers since 1989 through 2003, were collected retrospectively. Pncretic pseudocysts were confirmed y their lck of epithelil lining in the cyst wll iopsy, the high concentrtion of pncretic enzymes, nd their formtion t lest 4 weeks fter n episode of cute pncretitis or pncretic trum. Only the ptients who needed opertion due to cute compliction such s infection, peritonitis, scites, or leeding nd symptomtic PP, were included in this study. The sizes of the PPs were recorded from opertive findings or mesurement of the PPs in CT imge. Pertinent dt included ge, sex, ssocited diseses, clinicl findings, opertive procedures performed, nd postopertive course. Durtion of follow-up ws 2 months to 14 yers with the verge of 5.91 yers RESULTS From 1989 through 2000, 17 ptients with pncretic pseudocysts in Hulien Tzuchi Generl Hospitl, nd from 2001 through 2003, 5 ptients in Dlin Tzuchi Genrel Hospitl, were treted y the sme Generl Surgicl tem. Mle to femle rtio ws 14:8. The men ge ws 38.2 yers (rnge yers). The etiology is listed in Tle 1 nd lcoholism ws the most common cuse for pseudocyst. Regrding clinicl mnifesttions, dominl pin or fullness existed for 95.5% (n=21) nd fever nd leukocytosis ws detected in most of the complicted cses nd few uncomplicted cysts (n=10, 45.5%), nd seven cses presented with plple mss in the domen (31.8%). There were lso some nonspecific GI symptoms such s nuse nd vomiting in nerly hlf of the cses. Ojective documenttion of pncretic pseudocyst ws otined y ultrsonogrphy (n=17, 77.2%) (Figure 1), computed xil tomogrphy (n=18, 81.8%) (Figure 1) or endoscopic retrogrde pncretogrphy (n=5, 22.7%). Most of the PPs resolved nd were followed y sonogrphy (Figure 2) nd CT (Figure 2). The indictions for surgery nd the procedure performed re summrized in Tles 2 nd 3 respectively. The sizes of the PP could e recorded for 13 elective cses nd 7 emergency cses. All of the PP mesured more thn 6cm in size nd the verge size ws 8.2cm. 11 cses showed more thn 10cm in size. The lrgest one mesured 40x30x15cm in size nd occupyed more thn hlf of the domen including the TABLE 1 Presumed Cuse of Pncretic Pseudocyst Cuse Numer (%) Alcohol 10 (45.5%) Biliry 2 (9.1%) Alcoholic nd trum 2 (9.1%) Trum 3 (13.6%) Hyperlipidemi 1 (4.5%) Idiopthic 4 (18.2%) Totl 22 (100%)
3 Pncretic Pseudocyst Hepto-Gstroenterology 52 (2005) 1269 pelvic cvity. ERCP ws performed in 5 cses nd four were done preopertively. One of them ws done for ptient with recurrent cyst complicted with respirtory filure from mssive pleurl effusion secondry to pncreticopleurl fistul. The prolem ws solved y trnsppillry dringe y n endoscopist. The cyst ws infected in cse following ERCP nd urgent lprotomy with externl dringe ws performed. Percutneous dringe under sonogrphy or CT ws done in 4 cses nd hlf of them were used in postopertive pncretic scess nd recurrent pseudocyst respectively. Preopertive usge in one cse ws unfortuntely complicted with lekge of pncretic juice round the ctheter leding to diffuse peritonitis. Opertive procedures used in these ptients re listed in Tle 3. All of the complicted cysts except one infected cyst were operted y externl dringe. Internl dringe ws crried out in nother 12 symptomtic mtured pseudocysts nd distl pncretectomy ws done in ptient with PP t the til. CG ws performed in more thn hlf of the ptients (66.6%, Figure 3). Suture ligtion outside the cyst for leeding pseudoneurysm ws done in two cses nd prtil gstrectomy ws dded for cse presenting with cyst perfortion into the stomch Significnt moridity occurred in 10 of 22 ptients (45.5%) nd six of them (60%) hppened in ptients with externl dringe: Three cses with pncreticocutneous fistul, 2 cses with recurrence of pseudocyst, nd one cse of colon perfortion occurred in the ED group. All three fistuls closed spontneously with conservtive mngement including totl prenterl nutrition followed y enterl feeding. One of the recurrent pseudocysts ws treted first with percutneous dringe. Endoscopic stenting t initil ttempt filed. Unfortuntely, it recurred (Figure 4-c) nd ws complicted with pncreticopleurl fistul ssocited mssive pleurl effusion nd respirtory filure eight months lter (Figure 5-c). However, it finlly responded well to the successful trnsppillry stent insertion (Figure 5d). Urgent proximl colostomy ws done for colon perfortion nd reconstruction ws crried out hlf yer lter. Two recurrences occurred in the CJ group nd only one of them needed second internl enteric dringe gin 9 yers lter ecuse of iliry ostruction. The other ptient didn't need opertion fter spirtion percutneously. A delyed TABLE 2 Indictions for Surgery Type of Presenttion Numer 1. Symptomtic, persistent lrge pseudocyst (>6cm) Vrious types of compliction. Infected cyst 6. Free rupture with peritonitis 1 c. Rupture into stomch with peritonitis 1 d. Ruptured pseudoneurysm (gstroduodenl) 2 into duodenum or peritonel cvity e. Pncretic scites 1 Totl 22 TABLE 3 Opertive Procedures Procedures Numer (%) 1. Externl dringe 9 (40.9%) 2. Internl dringe Cystogstrostomy 8 (36.4%) Cystojejunostomy 4 (18.2%) 3. Distl pncretectomy 1 (4.5%) Totl 22 (100%) mssive leeding ws found in the CG group. He ws prompted to hve n opertion for cesstion of nstomotic leeding on the seventh postopertive dy. A cse with gint cyst (Figure 6) treted y CJ technique ws complicted with pncretic scess formtion nd it ws finlly solved y percutneous dringe with lrge ore drin tue (Figure 6 nd c). No opertive deth occurred. DISCUSSION Acute destructive pncretitis cn led to the formtion nd development of pseudocysts (8-10). A pncretic pseudocyst is n extrvsted collection of exocrine pncretic juice surrounded y firous memrne mde of djcent viscer nd prietl wll devoid of n epithelil lining. Surgicl tretment of pncretic pseudocysts is still controversil regrding the optiml time for intervention, the choice of surgicl technique nd the choice of mngement in cses of complictions. In ddition to the surgicl pproch, pproprite usge of the dignostic imging studies nd nonopertive techniques re the fundmentls of success in the mngement of the pncretic pseudo- FIGURE 3 Cystogstrostomy. () Locliztion of the PP y trnsgstric pproch. () Cystogstrostomy ws done y nonsorle interlocking sutures.
4 1270 Hepto-Gstroenterology 52 (2005) W-Y Yin, H-T Chen, S-M Hung, et l. cyst. Pncretic pseudocysts re recognized in over 10% of cses of pncretitis. They occur s result of pncretic inflmmtion, trum, or duct ostruction. As is the cse with most series, lcohol-relted pncretitis ws the entity most commonly ssocited with pseudocysts in our series (5). Although we hve two cses llocted in comined etiology of lcohol nd trum, they sustined dominl trum one to four yers efore the opertion. Pncretic pseudocyst should e suspected in ptients with cute pncretitis whose symptoms fil to resolve within 7 to 10 dys or in ptients with chronic pncretitis who complin of persistent pin, nuse, or vomiting. As in the most series in the literture, epigstric pin or fullness ccounted for 95.5%. But less percentge (n=7, 31.8%) of plple dominl mss ws noted in our series. The most relile wy of mking dignosis is y ultrsound or CT scnning. Hessel found ultrsound to e 90% ccurte nd 98% specific when the pncres could e visulized. Unfortuntely gs oscures the pncres in nerly one third of the ptients. CT scn hve incresed sensitivity nd specificity nd provided dditionl informtion out retroperitonel extension nd the reltionship etween cyst nd djcent enteric lumen (11). Computed xil tomogrphy (CT) nd ultrsound re eqully ccurte for cysts in our cses s most of them were >5cm in dimeter (Figure 1). But they were used only in 80% of our cses for dignosis nd cses in emergency sitution were immeditely operted. An initil preopertive CT scn with correlted sonogrphy followed y seril sonogrphic exmintions ws noted to e very effective for oservtion of the cyst condition efore nd fter the opertive tretment. We used this method in our cses nd most of them could clerly demonstrte the resolution (Figure 2) or recurrence of the cyst (Figure 4). Routine use of ERCP is still controversil. ERCP demonstrtes normlities of the pncretic duct in up to 90% of the ptients with pseudocyst nd nerly two-thirds of the pseudocysts communicte with the pncretic duct. So ERCP my provide vlule informtion concerning the nturl course of pseudocysts nd selection of suitle cndidtes for nonopertive mngement. Severl studies suggest tht routine ERCP should e considered in ll ptients with pseudocysts to optimize tretment strtegy (8,12). Neolon et l. (8) reported tht routine ERCP chnged the opertive mngement in nerly 60% of their ptients nd improved their outcome. But it is still ssocited with excertion of cute pncretitis, infection of pseudocyst, nd other endoscopic relted complictions. A cse in our series contrcted infection of the pseudocyst with sepsis severl hours following investigtion. We use ERCP only in elective symptomtic cses ut mturtion of the wll in CT ws not enough for cyst-enteric nstomosis, s the mngement will vry ccording to the findings. In such cses, percutneous dringe my e considered if ERCP showed no communiction etween the cyst nd pncretic duct. Trnsppillry pncretic stenting my e plnned for cses with connection. We my lso rrnge it in ptients with suspected pncretic cncer nd reluctnce for opertion. Otherwise, pproprite opertive procedure ws chosen stright forwrd for mture nd uncomplicted cses. Therefore, ERCP ws not routinely done y us nd ws performed only in selected cses. If done, it should e performed within hours efore plnned dringe procedure under the umrell of ntiiotics. Angiogrphy is generlly not useful for dignosis of pseudocyst. We elieve tht using these modlities only in complementry fshion my give us the est result with ggregte specificity pproching 100%. The dvent of sonogrphy nd CT scn of the domen in the 1970s hs clerly estlished tht pproximtely 50% of pseudocysts resolve spontneously (6,13-15). A review of the literture lso revels tht up to 40% of ptients with untreted pseudocyst develop complictions lthough some previous studies were predicted on ptients who were identified ecuse of symptoms (11). Resolution of pncretic pseudocyst nd development of complictions were therefore thought to e function of time. As mtter of fct, it is gret chllenge for surgeon to decide when to operte on the ptient with PP in order to void unnecessry consequences. However, there re few longitudinl studies of pseudocysts. The Myo clinic experience reported y Vits nd Srr (6) review 68 ptients with symptomtic pncretic pseudocysts. At men follow-up of 51 months, 63% remined symptomtic. In 6 ptients (9%) significnt c FIGURE 4 Recurrence of PP. () Sonogrphic finding fter ED. () CT finding fter ED. (c) CT finding fter percutneous dringe.
5 Pncretic Pseudocyst Hepto-Gstroenterology 52 (2005) 1271 FIGURE 5 Pncreticopleurl fistul following ED. () Mssive pleurl effusion. () CT finding of mrkedly collpsed right lung. (c) ERCP showed pncretic ductl lekge. (d) Resolution of PP fter trnsppillry dringe. c d complictions developed, including intrcystic hemorrhge, perfortion, nd infection. Of the 35% who required therpy, five cses were emergent nd the remining were elective, with either pin, cyst enlrgement, or gstric or iliry ostruction. The men size of the pseudocyst ws less thn 6cm, nd only surgicl therpy ws used. A similr study y Yeo et l. (15) t Johns Hopkins University included 36 ptients with pncretic pseudocysts. Spontneous resolution occurred in 69% of the cses t 1-yer follow-up. In 40% of the cses, pncretic pseudocysts were stle or smller. These ppers encourged expectnt tretment of the pncretic pseudocysts. However oth studies were short in follow-up durtion (1 to 4 yers) nd the PP were smll in verge size. In Vits series, there were significnt mount of cse with the cyst ge of <6 weeks (31%) nd indeterminte durtion (41%) in his group II who were ssigned to undergo nonopertive noninterventionl expectnt mngement. In ddition, only 24 of 43 ptients were followed completely y rdiogrphic surveillnce nd the risk of eventul opertion tretment incresed in prllel with incresing size of PP (28 to 57%). In the Myo series, they still encountered significnt mount of cses with complictions necessry for emergent opertion. On the other hnd, Brdley et l. (16) hve ffirmed the vlue of witing period. Their dt suggested tht spontneous resolution occured in 40% of the cute pncretitis cses with durtion less thn 6 weeks, nd the compliction rte ws only 20%. A witing period greter thn 7 weeks, however, ws ssocited with 56% compliction rte nd spontneous resolution ws oserved in only 1 of 25 ptients from 7-18 weeks. But current review of recent studies y Pitchumoni nd Agrwl (17) pointed tht one solute, n dge of surgicl trining tht 6-cm pseudocyst present for 6 weeks or more requires surgery, is solutely untrue. We hve 50% (11/22) of complicted cses in our series either preopertively or postopertively. Although there ws no mortlity, they were often ssocited with severe moridity. As they ll were dignosed t the first visit, we could not know the ge of the PP efore tht episode. Even in the elective cses, those with lrger pseudocysts were finlly involved with some complictions. Two cses with huge PP (>15cm) sustined pncretic infection following ERCP in one cse nd lekge of pncretic juice round the dringe ctheter with diffuse peritonitis following percutneous dringe in the other ptient. The third cse contrcted severe hemodynmic chnge nd pncretic scess following internl dringe due to sudden mssive fluid loss with indequte replcement nd poor dringe respectively. So we should keep in mind tht huge PP my e more difficult to hndle thn n verge sized PP (6cm to 10cm) in every step of tretment. The other fctor we could trce in our ptients is tht the complicted cses were much more relted with lcoholic history (7/11). Therefore, we would like to ssume tht incresed wreness nd erly intervention should e crried out in cses presenting with huge PP especilly with n lcoholic history. We lso hve pinful experience of opertion in symptomtic ptient with n immture cyst wll who ended up with recurrence
6 1272 Hepto-Gstroenterology 52 (2005) W-Y Yin, H-T Chen, S-M Hung, et l. fter externl dringe (Figure 4-c) nd severe pulmonry effusion due to pncreticopulmonry fistul even fter percutneous dringe ws done (Figure 5-c). It ws ultimtely treted uneventfully y trnsppillry dringe (Figure 5d). So we do gree tht Pitchumoni's considertion is resonle nd rtionl ut the old 6cm-6 weeks criteri for intervention should still e reltive indictor rther thn n solute one. Surgicl dringe hs een the gold stndrd for mnging PP. However, it is ssocited with significnt moridity nd mortlity s mentioned ove. Despite reltively limited experience with percutneous dringe nd despite recurrence nd filure rtes rnging s high s 25% to 79%, these methods re recommended incresingly s the first line of tretment (3,18-22). vonsonnenerg et l. reported 94% cure rte of 51 ptients with infected PP treted y percutneous dringe. The fistul usully closed in less thn 30 dys (21). Adms nd Anderson (22) reviewed 52 ptients who underwent CT-guided dringe. All ptients hd pncretic fistuls nd hd n verge hospitl sty of 40 dys. The verge durtion of fistul dringe ws 42.1 dys, nd in 48% of the ptients it ws further prolonged y drin trct infection. Sometimes these ptients filed to respond to conservtive tretment nd required opertive intervention (23). Roert Ro in his interesting pper concluded tht filed nonopertive dringe is ssocited with protrcted illness nd cries risk of incresed moridity fter opertive intervention. They lso pointed out tht 39% of their ptients undergoing pncretic duct dringe for chronic pncretitis hd PP. So they suggested these two coexisting prolems e treted t the sme time whenever possile. We used percutneous dringe in ptient crrying lrge infected PP with systemic toxemi including fever nd leukocytosis. But it ws complicted with lekge round the ctheter with diffuse peritonitis. It, on the hnd, relly helped to control postopertive pncretic scess with sepsis y effective dringe through wide ore drin tue. Theoreticlly, endoscopic dringe of PP more closely mimics opertive internl dringe. But n inherent prolem with endoscopic dringe is tht not ll the PP re continuous with stomch or duodenum. In ddition, it is techniclly demnding nd widely known for initil success ut erly recurrence (24). Similrly, cse in the ED group who sustined recurrent PP complicted with pncreticopleurl fistul even fter postopertive percutneous dringe ws relieved y trnsppillry dringe lter nd it remined stle until recent follow-up. We therefore stick to the surgicl intervention s n initil tretment of choice in generl for cses with indiction s well s eing fit for nesthesi nd opertion. For selected cses such s those with infected PP nd with frile thin wll, unstle clinicl condition, or suspect mlignncy, we my rrnge percutneous dringe to control the cute episode. Then further imging study will e followed efore definitive surgicl tretment. For the ptients, who re dignosed incidentlly, they re put on list for regulr follow-up especilly for lrge PP. Appernce of symptoms or increse in the size of PP will e n indictor for the intervention. Percutneous or endoscopic trnsppillry pproch my lso e chosen for the symptomtic cses with thin wll or reluctnce to c FIGURE 6 Clinicl course of gint PP. () A huge PP occupying hlf of the domen including pelvis. () Percutneous dringe with pigtil ctheter in pncretic scess. (c) Multiple drins including wide ore tue in different loctions for etter dringe.
7 Pncretic Pseudocyst Hepto-Gstroenterology 52 (2005) 1273 TABLE 4 Postopertive Moridity nd Mngement with Different Opertive Methods Procedures Complictions Numer (%) Mngement 1. Externl dringe 1. Recurrence 1 Aspirtion 2. Recurrence with pncreticopleurl fistul 1 Trnsppillry dringe 3. Colon perfortion 1 Colostomy 4. Pncretic fistul 3 Conservtive Sutotl 6 (60%) 2. Internl dringe Cystogstrostomy (CG) 1. Internl leeding 1 Reopen one week lter 2. Persistent pin 1 Conservtive Cystojejunostomy (CJ) 1. Recurrence 1 Cystojejunostomy 2. Pncretic scess 1 Percutneous dringe 3. Resection Sutotl 4 (40%) Distl pncretectomy Nil Nil Totl 10 (100%) undergo opertive procedures t their first ttempt. Complete dependent dringe is criticl in ny internl dringe procedure nd solid mteril lining pseudocyst should e thoroughly derided t the time of internl dringe. Cystogstrostomy ws chosen when the cyst wll ws dherent to the posterior gstric wll (Figure 4). If the cyst wll is dherent to the duodenl wll, cystoduodenostomy should e performed. Cystojejunostomy ws used when the cyst ws not closely dherent to the upper gstrointestinl trct nd ws locted t the se of the trnsverse mesocolon. It is lso suggested for extremely lrge PP (>15cm) so s to chieve dependent dringe (11,17). An infected pseudocyst presents s secondry infection of previously sterile pseudocyst. The chnce of progression from sterile to n infected pseudocyst increses with time nd occurs in pproximtely 10-15% of PP (16). Infection my e due to trnsloction of cteri from the GI trct, secondry infection of n intrcystic hemtom or my e itrogenic fter puncture or ERCP (25). Externl dringe is the trditionl surgicl therpy for infected pseudocyst nd is thought to e preferle to cystoenterostomy, since the cretion of nstomosis in n infected field is thought to e unsfe with the risk of postopertive scess formtion. But development of pncreticocutneous fistul hs een descried to occur in 12-20% of ptients fter externl dringe (26). Djmil Boerm (27) proved in his series tht surgicl internl dringe is sfe nd effective in selected cses tht hd firm cyst wll nd could hold nstomosis well. We used this technique only in one ptient out of 5 cses with infected PP ecuse of diffuse peritonitis or ssocited systemic toxemi in other 4 ptients. The ptient who used ID recovered uneventfully in the postopertive period. In contrst, out of the remining 4 cses, one ended up with colon perfortion in nd two with prolonged hospitl sty for pncretic fistul. So we would lso like to encourge the use of ID in those cses tht possess mture cyst wll ut do not revel systemic toxemi nor diffuse peritonitis. The mortlity nd recurrence rte for ED nd ID re 10% vs. 3% nd 18% vs. 8% respectively (17). 10% of persistent pncretic fistul in ED my necessitte distl pncretectomy or dringe into Roux lim of owel. In our series, ID ws ssocited with higher moridity thn internl dringe (n=6, 66.6% vs. n=3, 25%) if the cses tht got persistent pin, proly due to chronic pncretitis precipitted y continued lcoholic drinking, were excluded (Tle 4). It is significntly higher thn the 23% y Blfour (28) nd quite similr to 72.7% nd 61% noted in Brin et l. (4) nd Shtney's (29) series respectively. But we elieve tht opertive technique should not e the sole responsile fctor for this negtive result. We used this procedure in most of the emergency nd complicted ptients. It might e siclly due to complex stte of the disese itself t the time of opertion nd lck of the chnce of evlution of the pncretic ductl condition preopertively in such emergent nd cutely ill ED ptients. Fortuntely, only one cse in ech group needed reopertion in the sme dmission due to leeding nd indvertent colon injury with perfortion respectively. Endoscopic intervention (trnsppillry dringe) of ptient with pncreticopleurl fistul in the ED group nd rdiologic intervention (percutneous dringe) in ptient with postopertive pncretic scess in the ID group prevented oth of them from undergoing reopertion. Therefore multidisciplinry pproch y well-experienced tem composed of surgeon, endoscopist, nd rdiologist is fundmentl for the est outcomes % of the fistuls will close spontneously within 4 months. But high output (>200cc/dy) ppers to extend the durtion of closure (30). Three in our ED group confronted pncretic fistul nd they were mnged y totl prentl nutrition (TPN) in the erly dys followed y jejunostomy feeding in ll ptients. Noody needed reopertion or prolonged TPN. All fistuls closed within 1-2 months. Consequently, less intervention ws needed in the ID group (33.3%) in contrst to the ID group (50%) (AUTHOR plese specify which should e ID nd which should e ED). If ll need for reoper-
8 1274 Hepto-Gstroenterology 52 (2005) W-Y Yin, H-T Chen, S-M Hung, et l. tion ws included, significntly lower incidence of only 16.6% (one out of 6 cses) in the ED group compred to 75% (3 out of 4) in the ID group ws found. So erly TPN comined with routine use of erly jejunostomy feeding my e the most importnt strtegy for this result. A well-orgnized surgicl nutrition tem should e grnted gret credit for this wonderful gin. We encountered mssive leeding from nstomosis of cystogstrotomy 7 dys fter opertion nd needed emergency reopertion for hemostsis. It is quite common to find few cses s in our studies nd most series (31) with higher incidence of up to 50% (32) though there re lso few studies without this life-thretening compliction (4). This hs een ttriuted to reflux of digestive juices with enzymtic ctivtion (33). Use of sorle suture might e the cuse for such trgedy. Non-sorle sutures with interlocking suturing method my secure hemostsis etter long the cyst-enteric nstomosis. No such compliction occurred in our lter cses. Interestingly, recurrence of pseudocyst hppened in one cse 9 yers fter initil opertion with cystojejunostomy nd it ws ssocited with iliry ostruction. Adominl discomfort nd repeted jundice prompted him to receive second cystojejunostomy. It might e due to the stenotic chnge of the initil cystoenteric nstomosis nd persistent ductl lekge. Another prolem we met in our ptients pertining to the opertive technique ws the mngement of relly huge nd widely situted gint PP. It ws universlly greed tht gint cyst should e dependently drined y ID (11,17). But it led to severe complictions with sudden hemodynmic chnge nd pncretic scess in the erly postopertive dys (Figure 6, ). Mssive fluid loss nd indequte dringe with contmintion of the PP y drop of intestinl content from the disfunctioning lim of the Roux loop into the cvity should explin this unplesnt compliction. Such sorrowful dverse outcome ws reported y Johnson et l. in their four ptients with gint PP (>15cm). Three of four ptients hd life-thretening postopertive complictions s result of incomplete emptying of the cyst, nd two ptients died. They concluded tht CG my not e n pproprite tretment for the gint PP ecuse it filed to provide dependent dringe (34). Actully, it is impossile to drin internlly for such widely situted gint PP. Usge of trnsppillry dringe in comintion with percutneous dringe my e good lterntive in such cses if we cn prove presence of communiction etween the PP nd pncretic duct. It might hve precluded such severe dverse effect s mentioned ove. If we choose surgery, externl dringe rther thn internl dringe should e plced on first priority for such prticulr condition. Opertive mortlity ws high in erly times (8.6% to 16%) nd reduces significntly in recent yers with the rnge of 0% to 5% (35,36). We didn't hve ny mortlity in our series though complicted cses with emergency opertion were included. In summry, we treted 22 symptomtic cses of pseudocyst of the pncres including ptients with complictions y surgicl intervention s primry tretment from 1989 through 2003 t our hospitls nd most of them recovered uneventfully. The clinicl findings re vrile nd most of them presented with dominl pin or fullness. Ultrsonogrphy nd CT were eqully effective for dignosis ut sonogrphy ws noninvsive, chep nd useful for follow-up. Computed tomogrphic scnning ws lso helpful for evlution of locliztion, extent, correltion with surrounding structures, nd n imge guide to drin the cyst. Externl dringe of the PP ws ssocited with higher moridity thn ID. But only one in ech group needed to undergo reopertion. Percutneous dringe or endoscopic dringe my e good tool oth in the preopertive nd postopertive period. All these techniques for investigtion nd definitive tretment should e crried out coordintely s in n orchestr y tem pproch for the est outcomes. Although there ws some moridity, there ws no mortlity in our whole series. REFERENCES 1 LeDentu C: Rpport sur I'oservtion precedente. Bull Soc Ant Pris 1865; 40: Vitle GC, Lwhon JC, Lrson GM, Hrrell DJ, Red DN Jr, McLeods: Endoscopic dringe of the pncretic pseudocyst. Surgery 1999; 1264: Heider R, Meyer AA, Glnko JA, Behrns KE: Percutneous dringe of pncretic pseudocysts is ssocited with higher filure rte thn surgicl tretment in unselected ptients. Ann Surg 1999; 229: Boggs BR, Potts JR 3rd, Postier RG: Five yer experience with pncretic pseudocysts. Am J Surg 1982; 144: Mullins RJ, Mlngoni MA, Bergmini TM, Csey JM, Richrdson JD: Controversies in the mngement of pncretic pseudocysts. Am J Surg 1998; 155: Vits GJ, Srr MG: Selected mngement of pncretic pseudocysts: Opertive versus expectnt mngement. Surgery 1992; 111: Pvlovsky M, Perejslov A, Chooklin S, Dovgn: Current mngement of pncretic pseudocysts. Heptogstroenterology 1998; 45: Nelon WH, Townsend CM Jr, Thompson JC: Preopertive endoscopic retrogrde cholngiopncretogrphy (ERCP) in ptients with pncretic pseudocyst ssocited with resolving cute nd chronic pncretitis. Ann Surg 1989; 209: Kozrek RA, Bll TJ, Pterson DJ, Freeny PC, Ryn JA, Trverso LW: Endoscopic trnsppillry therpy for disrupted pncretic duct nd peripncretic fluid collection. Gstroenterology 1991; 100: Deviere J, Bueso H, Bize M, et l: Complete disruption of the min pncretic duct: Endoscopic mngement. Gstrointest Endosc 1995; 42: Andrew LW, Crlos FC, Dvid WR: Pncretic cysts, pseudocysts, nd fistuls. In: Michel JZ, Seymour IS, Hrold E (Eds.). Minogt's dominl opertions. 10th Edition. London: Appleton & Lnge, 2000; pp Sugw C, Wlt AJ: Endoscopic retrogrde pncretogrphy in the surgery of pncretic pseudocysts. Surgery 1979; 86: Arnh GV, Prinz RA, Esguerr AC, Greenlee HB: The nture nd course of cystic pncretic lesions dignosed y ultrsound. Arch Surg 1983; 118: Beee DS, Bururick MP, Onstd GR, et l: Mnge-
9 Pncretic Pseudocyst Hepto-Gstroenterology 52 (2005) 1275 ment of pncretic pseudocysts. Surg Gynecol Ostet 1989; 159: Yeo CJ, Bstides JA, Lynch-Nyhn A, Fishmn EK, Zinner MJ, Cmeron JL: The nturl history of pncretic pseudocysts documented y computed tomogrphy. Surg Gynecol Ostet 1990; 170: Brdley EL III, Clemcnrs JL, Gonzlez AC: The nrurl history of pncretic pseudocysts: A unified concept of mngement. Am J Surg 1979; 137: Pitchumoni CS, Agrwl N: Pncretic pseudocysts. When nd how should dringe e performed. Gstroenterol Clin North Am 1999; 28: Torres WE, Evert MB, Bumgrtner BR, Berndino ME: Percutneous spirtion nd dringe of pncretic pseudocysts. AJR 1986; 147: Aurell Y, Forserg L, Hederstrom E, Anderson R: Percutneous puncture nd dringe of pncretic pseudocysts. A retrospective study. Act Rdiol 1990; 31: Adms DB, Hrvey TS, Anderson ML: Percutneous ctheter dringe of pncretic pseudocysts. Am Surg 1991; 57: Vn Sonnenurg E, Wittich GR, Csol G, et l: Percutneous dringe of infected nd noninfected pncretic pseudocysts: Experience in 101 cses. Rdiology 1989; 170: Adms DB, Anderson MC: Percutneous ctheter dringe compred with internl dringe in the mngement of pncretic pseudocyst. Ann Surg 1992; 215: Ro R, Fedork I, Prinz RA: Effect of filed computed tomogrphy-guided nd endoscopic dringe on pncretic pseudocyst mngement. Surgery 1993; 114: Cremer M, Deviere J, Engelholm L: Endoscopic mngement of cysts nd pseudocysts in chronic pncretitis: Long-term flow-up fter 7 yers of experience. Gstrointest Endosc 1989; 35: Fedork IJ, Ko TC, Djuricin G, McMhon M, Thompson K, Prinz RA: Secondry Pncretic infections: Are they distinct clinicl entities? Surgery 1992; 112: Mrtin EW, Ctlno P, Coopermn M, Hecht C, Crey LC: Surgicl decision-mking in the tretment of pncretic pseudocysts: Internl versus externl dringe. Am J Surg 1979; 138: Boerm D, vn Gulik TM, Oertop H, Goum DJ: Internl dringe of infected pncretic pseudocysts: Sfe or sorry? Dig Surg 1999; 16: Blfour JH: Pncretic pseudocysts: Complictions nd their reltionship to the timing of tretment. Surg Clin North Am 1970; 50: Shtney CH, Lillihei RC: Surgicl tretment of pncretic pseudocysts. Ann Surg 1797; 189: Zinner MJ, Brker RR, Cmeron JL: Pncretic cutneous fistuls. Surg Gynecol Ostet 1974; 138: Rosenerg IK, Khn JA, Wlt AJ: Surgicl experience with pncretic pseudocysts. Am J Surg 1969; 117: Huston DG, Zepp R, Wrren WD: Prevention of postopertive hemorrhge fter pncretic cystogstrostomy. Ann Surg 1973; 193: Mroutti RA, Spin GP, Znnini P, et l: Current mngement of pncretic pseudocysts. Int Surg 1982; 67: Johnson LB, Rttner DW, Wrshw AL: The effect of size of gint pncretic pseudocysts on the outcome of internl dringe procedures. Surg Gynecol Ostet 1991; 173: Becker WF, Prtt HS, Gnji H: Pseudocysts of the pncres. Surg Gynecol Ostet 1968; 127: Thomford NR, Jesseph JE: Pseudocyst of the pncres. A review of fifty cses. Am J Surg 1969; 118: AUTHOR PLEASE CHECK HIGHLIGHTED AREA IN DISCUSSION SECTION
BENIGN ulceration along the greater curvature of the pars media of the
BENIGN ULCERS OF THE GREATER CURVATURE OF THE STOMACH Report of Two Cses CHARLES H. BROWN, M.D. Deprtment of Gstroenterology nd ANTHONY D. INTRIERE, M.D.* BENIGN ulcertion long the greter curvture of the
More informationComputed Tomography for Localization of Intra- Abdominally Dislocated Intrauterine Devices
Act Rdiologic ISSN: 0284-1851 (Print) 1600-0455 (Online) Journl homepge: https://www.tndfonline.com/loi/ird20 Computed Tomogrphy for Locliztion of Intr- Adominlly Dislocted Intruterine Devices Esjörn Hederström,
More informationPancreatic Adenocarcinoma Presenting as Acute Large Bowel Obstruction: Case Report
IMAGES IN CLINICAL MEDICINE Surg. Gstroenterol. Oncol. 2018;23(3):204-208 DOI: 10.21614/sgo-23-3-204 Pncretic Adenocrcinom Presenting s Acute Lrge Bowel Ostruction: Cse Report Inês Cmpos Gil 1, Din Prente
More informationFindings in spontaneous intramural intestinal hematoma imaging
Brief report Findings in spontneous intrmurl intestinl hemtom imging F. Mirs Azcón, A. Mrtínez Mrtínez, A. Sntigo Chinchill*, A. Medin Benítez, E. Ochndo Pulido nd M.A. Pérez Rosillo Imging deprtment,
More informationPNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :
PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged
More informationEmerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data
Emerging Options for Thromboprophylxis After Orthopedic Surgery: A Review of Clinicl Dt Bob L. Lobo, Phrm.D. In four rndomized, controlled studies of ptients undergoing orthopedic surgery, the ntithrombotic
More informationC reactive protein: an aid to assessment and
C rective protein: n id to ssessment nd monitoring of cute pncretitis J Clin Pthol 1984;37:27-211 AD MAYR,* MJ McMAHON,* MARGART BOWN,t H COOPRt From the *University Deprtment ofsurgery, Generl Infrmry,
More informationGeneral Microscopic Changes
Generl Microscopic Chnges 2 This chpter covers collection of microscopic chnges tht lck dignostic specificity ut occur in different specific diseses, s will ecome pprent in susequent chpters. Almost ll
More informationColonoscopic decompression of childhood sigmoid and cecal volvulus
CASE REPORT Colonoscopic decompression of childhood sigmoid nd cecl volvulus Irj Shhrmin 1, Ali Bzi 1,2, Dnil Edti 3, Krim Rostmi 3, Mojt Delrmns 1,2 1 Peditric Digestive nd Heptic Reserch Center, Zol
More informationThe Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report
Hiroshim J. Med. Sci. Vol. 65, No. 1, 13~17, Mrch, 2016 HIJM 65 3 13 The Selective Arteril Clcium Injection Test is Vlid Dignostic Method for Invisile Gstrinom with Duodenl Ulcer Stenosis: A Cse Report
More informationEFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE
Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.
More informationXII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV
XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies
More informationLipase and Pancreatic Amylase Activities in Tissues and in Patients with Hyperamylasemia
CLINICAL CHEMISTRY Originl Article Lipse nd Pncretic Amylse Activities in Tissues nd in Ptients with Hypermylsemi FRED APPLE, PH.D, PETER BENSON, M.D., LYNNE PREESE, MT, M.B.A., STEVEN EASTEP, M.D., LAURA
More informationInput from external experts and manufacturer on the 2 nd draft project plan Stool DNA testing for early detection of colorectal cancer
Input externl experts nd mnufcturer on the 2 nd drft project pln Stool DNA testing for erly detection of colorectl cncer (Project ID:OTJA10) All s nd uthor s replies on the 2nd drft project pln Stool DNA
More informationPerforation Following Colorectal Endoscopy: What Happens Beyond the Endoscopy Suite?
credits vilble for this rticle see pge 88. Originl RESEARCH & CONTRIBUTIONS Perfortion Following Colorectl Endoscopy: Wht Hppens Beyond the Endoscopy Suite? Michel S Tm, MD; Mher A Abbs, MD, FACS, FASCRS
More informationA Case of Intraductal Papillary Mucinous Carcinoma in the Head of the Pancreas Associated With Absence of the Duct of Wirsung
CASE REPORT A Cse of Intrductl Ppillry Mucinous Crcinom in the Hed of the Pncres Associted With Asence of the Duct of Wirsung Ismu Mkino, Tkhis Ymguchi, Mitsuyoshi Okzki, Tomohru Miyshit, Hidehiro Tjim,
More informationThe effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel
Gut, 1971, 12, 11-15 The effects of diversion of intestinl contents on the progress of Crohn's disese of the lrge owel J. H. BURMAN, H. THOMPSON, W. T. COOKE, AND J. ALEXANDER WILLIAMS From the Nutritionl
More informationComputed Tomography after Modified Whipple Procedure with Pancreatic Duct Occlusion
Act Rdiologic ISSN: 0284-1851 (Print) 1600-0455 (Online) Journl homepge: https://www.tndfonline.com/loi/ird20 Computed Tomogrphy fter Modified Whipple Procedure with Pncretic Duct Occlusion A. Aildgrd,
More informationUsing Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids
Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress
More informationOptimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality
Optimistion of diets for Atlntic cod (Gdus morhu) roodstock: effect of rchidonic cid on egg & lrvl qulity Dr Gordon Bell, Ms. An Blnco, Dr Bill Roy, Dr Derek Roertson, Dr Jim Henderson nd Mr Richrd Prickett,
More informationDiagnostic peritoneal fluid aspiration: a simple maneuver to diagnose a major question: a prospective study surgical point of view
Interntionl Surgery Journl Mohmed AHH et l. Int Surg J. 2017 Sep;4(9):2952-2956 http://www.ijsurgery.com pissn 2349-3305 eissn 2349-2902 Originl Reserch Article DOI: http://dx.doi.org/10.18203/2349-2902.isj20173680
More informationBiliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan
J Heptoiliry Pncret Surg (2009) 16:1 7 DOI 10.1007/s00534-008-0015-0 TOPICS Biliry trct cncer sttistics registry in Jpn Biliry trct cncer tretment: 5,584 results from the Biliry Trct Cncer Sttistics Registry
More informationFundamentals of Spine MRI and Essential Protocols
Fundmentls of Spine MRI nd Essentil Protocols A. C. Dougls-Akinwnde, MD Octoer 13, 2009 Fundmentls of Spine MRI Lerning Ojectives: 1. List the essentil sequences for Spine MRI exmintion 2. Discuss the
More informationAnus,Rectum and Colon
JOURNAL OF THE Anus,Rectum nd Colon http://journl-rc.jp CASE REPORT Anl Cnl Dupliction Associted with Prescrl Cyst in n Adult Tkyuki Toyong 1), Hiromitsu Mtsud 1), Ryuichi Miu 1), Yohei Toming 1), Keiji
More informationBright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit
Bright Futures Medicl Reference Tle 2 to 5 Dy (First Week) Visit Universl Action Metolic nd Verify documenttion of neworn metolic screening results, pproprite rescreening, nd needed follow-up. Document
More informationAnalysis of Risk Factors for the Development of Incisional and Parastomal Hernias in Patients after Colorectal Surgery
Originl Article Journl of the Koren Society of J Koren Soc Coloproctol 2012;28(6):299-303 http://dx.doi.org/10.3393/jksc.2012.28.6.299 pissn 2093-7822 eissn 2093-7830 Anlysis of Risk Fctors for the Development
More informationSummary of Package Insert 1
Summry of Pckge Insert 1 For Sttes with Non-Published Policies Indictions Non-infected prtil nd full-thickness skin ulcers due to VSU 2 of greter thn 1 month durtion nd which hve not dequtely responded
More informationBioactive milk components to secure growth and gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM
Bioctive milk components to secure growth nd gut development in preterm pigs ESTER ARÉVALO SUREDA PIGUTNET FA1401 STSM STSM Pigutnet FA1401 STSM 03/Septemer 30/Novemer/2017 (3 months) Host: Home: Thoms
More informationLocalized IgG4-related Cholecystitis Mimicking Gallbladder Cancer
CASE REPORT Loclized IgG4-relted Cholecystitis Mimicking Gllldder Cncer Tdhis Inoue 1, Fumihiro Okumur 1, Tkshi Mizushim 1, Hirotd Nishie 1, Hiroysu Iwski 1, Kiki Ane 1, Tknori Ozeki 1, Kent Kchi 1, Shigeki
More informationThe Dynamics of Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus
Chpter 2 The Dynmics of Vricell-Zoster Virus Epithelil Kertitis in Herpes Zoster Ophthlmicus The morphology of n individul VZV lesion reflects sequence of events triggered y the virus impct on cornel epithelil
More informationThallium-201 chloride scintigraphy in soft tissue tumors
136 ORIGINAL Thllium-201 chloride scintigrphy in soft tissue tumors Hideki Otsuk, Kori Terzw, Nomi Morit, Yoichi Otomi, Shoichiro Tko, Seiji Iwmoto, Kyosuke Oski, Msfumi Hrd, nd Hiromu Nishitni Deprtment
More informationPROVEN ANTICOCCIDIAL IN NEW FORMULATION
PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules
More informationResults of the Tokyo Consensus Meeting Tokyo Guidelines
J Heptobiliry Pncret Surg (2007) 14:114 121 DOI 10.1007/s00534-006-1163-8 Results of the Tokyo Consensus Meeting Tokyo Guidelines Toshihiko Myumi 1, Tdhiro Tkd 2, Yoshifumi Kwrd 3, Yuji Nimur 4, Mshiro
More informationBreast carcinomas: why are they missed?
O r i g i n l A r t i c l e Singpore Med J 2006; 47(10) : 851 Brest crcinoms: why re they missed? Muttrk M, Pojchmrnwiputh S, Chiwun B ABSTRACT Introduction: Mmmogrphy hs proven to e n effective modlity
More informationimri 2015;19:
pissn 2384-1095 eissn 2384-1109 imri 2015;19:241-247 http://dx.doi.org/10.13104/imri.2015.19.4.241 Pncretic Arteriovenous Mlformtion s n Unusul Cuse of Chronic Gstrointestinl Bleeding in Ptient with Erly
More informationCYSTIC TUMORS OF THE PANCREAS
gstrointestinl trct nd domen CYSTIC TUMORS OF THE PANCREAS Nichols J. Zyromski, MD Cystic tumors (neoplsms) of the pncres re fr more common thn once thought, developing in up to 10% of the generl popultion.
More informationSupplementary Online Content
Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern
More informationStudy of Stress Distribution in the Tibia During Stance Phase Running Using the Finite Element Method
Ksetsrt J. (Nt. Sci.) 48 : 729-739 (2014) Study of Stress Distriution in the Tii During Stnce Phse Running Using the Finite Element Method Thepwchr Ruchirh 1, Tumrong Puttpitukporn 1, * nd Siriporn Ssimontonkul
More informationTHE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS
THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS THE EVALUATION OF DEHULLED CANOLA MEAL IN THE DIETS OF GROWING AND FINISHING PIGS John F. Ptience nd Doug Gillis SUMMARY
More informationUtility of 128-slice Multi-detector Spiral Computed Tomography in Detecting Spectrum of Involvement in Acute Pancreatitis
Originl Article Print ISSN: 2321-6379 Online ISSN: 2321-595X DOI: 10.17354/ijss/2017/353 Utility of 128-slice Multi-detector Spirl Computed Tomogrphy in Detecting Spectrum of Involvement in Acute Pncretitis
More informationSevere Gummy Smile with Class II Malocclusion Treated with LeFort I Osteotomy Combined with Horseshoe Osteotomy and Intraoral Vertical Ramus
2013 67 1 5560 Severe Gummy Smile with Clss II Mlocclusion Treted with LeFort I Osteotomy Comined with Horseshoe Osteotomy nd Introrl Verticl Rmus Osteotomy * 56 Shimo et l. Act Med. Okym Vol. 67, No.
More informationChapter 02 Crime-Scene Investigation and Evidence Collection
Nme: Clss: Dte: Chpter 02 Crime-Scene Investigtion nd Evidence Collection 1. The terms grid, liner, qudrnt, zone, nd spirl re typiclly used to descrie dtum points... Flse Flse 2. An evidence log nd chin
More informationMeat and Food Safety. B.A. Crow, M.E. Dikeman, L.C. Hollis, R.A. Phebus, A.N. Ray, T.A. Houser, and J.P. Grobbel
Met nd Food Sfety Needle-Free Injection Enhncement of Beef Strip Loins with Phosphte nd Slt Hs Potentil to Improve Yield, Tenderness, nd Juiciness ut Hrm Texture nd Flvor B.A. Crow, M.E. Dikemn, L.C. Hollis,
More informationHilar cholangiocarcinoma accompanied by pancreaticobiliary maljunction without bile duct dilatation 20 years after cholecystectomy : report of a case
169 CASE REPORT Hilr cholngiocrcinom ccompnied y pncreticoiliry mljunction without ile duct dilttion 20 yers fter cholecystectomy : report of cse Shinichiro Ymd, Mitsuo Shimd, Tohru Utsunomiy, Yuji Morine,
More informationCord Injuries. on admission, and intermittent catheterization. (IC) was carried out until spontaneous voiding occurred.
JOURNAL OF CLINICAL MICROBIOLOGY, Nov. 1982, P. 856-860 0095-1137/82/110856-05$02.00/0 Copyright 1982, Americn Society for Microbiology Vol. 16, No. 5 Pseudomons eruginos Coloniztion in Ptients with Spinl
More informationSafety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA
Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,
More informationArthroscopic Anatomy of Shoulder
Arthroscopic Antomy of Shoulder Murt Bozkurt, Mehmet Emin Simsek, nd Hlil İrhim Açr 2 2.1 Introduction In the lst 30 yers, shoulder rthroscopy hs ecome of greter importnce in the dignosis nd tretment of
More informationCheck your understanding 3
1 Wht is the difference etween pssive trnsport nd ctive trnsport? Pssive trnsport is the movement of prticles not requiring energy. Movement of prticles in ctive trnsport uses energy. 2 A gs tp in the
More informationPerforative Peritonitis caused by Appendicitis in a Patient on Peritoneal Dialysis
CASE REPORT Perfortive Peritonitis cused y Appendicitis in Ptient on Peritonel Dilysis Msshi Mizuno 1,2, Ysuhiro Suzuki 1,2, Keisuke Nonk 2,YumiSei 2, Shoichi Mruym 2, Seiichi Mtsuo 2 nd Ysuhiko Ito 1,2
More informationOriginal Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:
Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute
More informationRadiographic evaluation of the technical quality of undergraduate endodontic competence cases in the Dublin Dental University Hospital: an audit
Rdiogrphic evlution of the technicl qulity of undergrdute endodontic competence cses in the Dulin Dentl University Hospitl: n udit Précis: An udit exmining the technicl qulity of undergrdute endodontic
More informationMultiple sclerosis (MS) affects approximately. Triaging Patients with Multiple Sclerosis in the Emergency Department. Room for Improvement
Systemtic Review of Tools for Anxiety in MS MS CARE DELIVERY: CHALLENGES AND INVATIONS Triging Ptients with Multiple Sclerosis in the Emergency Deprtment Room for Improvement Heshm Abboud, MD, PhD; Krin
More informationSupplementary Online Content
Supplementry Online Content Rieckmnn N, Kronish IM, Shpiro PA, Whng W, Dvidson KW. Serotonin reuptke inhibitor use, depression, nd long-term outcomes fter n cute coronry : prospective cohort study. JAMA
More informationSYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT
Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of
More informationClinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number
EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess
More informationWSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265;
FINAL REPORT WTFRC Project # AH-1-5 WSU Project # 13C-355-3 Project title: PI: Orgniztion: Coopertors: of Sunburn in Apples with RAYNOX Lrry Schrder, Horticulturist WSU Tree Fruit Reserch nd Extension
More informationUltrasound-guided antegrade access during laparoscopic pyeloplasty in infants less than one year of age: A point of technique
How I Do It Differently Ultrsound-guided ntegrde ccess during lproscopic pyeloplsty in infnts less thn one yer of ge: A point of technique Arvind Gnpule, Amit Bhttu, Shshiknt Mishr, Mhesh R Desi Deprtment
More informationA Rare Manifestation of Solitary Primary Bone Lymphoma of the Finger: a Case Report
pissn 2384-1095 eissn 2384-1109 imri 2018;22:240-244 A Rre Mnifesttion of Solitry Primry Bone Lymphom of the Finger: Cse Report Jeong A Yeom 2, You Seon Song 1 *, In Sook Lee 1, Kyung Un Choi 3, Jeung
More informationInvasive Pneumococcal Disease Quarterly Report July September 2018
Invsive Pneumococcl Disese Qurterly Report July Septemer Introduction Since 17 Octoer 2008, invsive pneumococcl disese (IPD) hs een notifile to the locl Medicl Officer of Helth under the Helth Act 1956.
More informationEVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1
Swine Dy 2001 Contents EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 C. W. Hstd, S. S. Dritz 2, J. L. Nelssen, M. D. Tokch, nd R. D. Goodbnd Summry Two trils were
More informationEffects of physical exercise on working memory and prefrontal cortex function in post-stroke patients
Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei
More informationAccuracy of Rotator Cuff Tears and Tendinosis Diagnoses on Shoulder Ultrasound Performed by a Short-experienced Operator
ORIGINAL ARTICLE Accurcy of Rottor Cuff Ters nd Tendinosis Dignoses on Shoulder Ultrsound Performed y Short-experienced Opertor Hrshd Arvind Vnjre, Jyoti Pnwr Deprtment of Rdiology, Christin Medicl College
More informationClinical manifestations in patients with alpha-fetoprotein producing gastric cancer
Curr Oncol, Vol. 21, pp. e394-399; doi: http://dx.doi.org/10.3747/co.21.1768 CLINICAL MANIFESTATIONS IN AFP PRODUCING GASTRIC CANCER ORIGINAL ARTICLE Clinicl mnifesttions in ptients with lph-fetoprotein
More informationIdentical twins with borderline lepromatous leprosy mimicking extensive alopecia areata: A rare presentation
Lepr Rev (2018) 89, 301 305 CASE REPORT Identicl twins with orderline lepromtous leprosy mimicking extensive lopeci ret: A rre presenttion RUBINA JASSI*, KRISHNA DEB BURMAN**, BHAVYA SWARNKAR** & RADHIKA
More informationNot for Citation or Publication Without Consent of the Author
Not for Cittion or Puliction Without Consent of the Author AN AUTOMATED SEX PHEROMONE TRAP FOR MONITORING ADULT CM AND OFM AND THE INFLUENCE OF TRAP COLOR ON MOTH AND NON-TARGET CAPTURES Brin L. Lehmn
More informationAddendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years)
Addendum to the Evidence Review Group Report on Aripiprzole for the tretment of schizophreni in dolescents (ged 15-17 yers) Produced by Authors Correspondence to Southmpton Helth Technology Assessments
More informationHealth-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery
Oesity Surgery, 15, 3-39 Helth-Relted Qulity of Life nd Symptoms of Depression in Extremely Oese Persons Seeking Britric Surgery Anthony N. Frictore, PhD; Thoms A. Wdden, PhD; Dvid B. Srwer, PhD; Myles
More informationAbnormalities of total serum magnesium concentration
J Vet Intern Med 2002;16:217 221 Prevlence nd Incidence of Serum Mgnesium Anormlities in Hospitlized Cts Jeffrey Toll, Hollis Er, Nichole Birnum, nd Thoms Schermerhorn Totl serum mgnesium concentrtion
More informationbuild Firm, sexy arms
w uild Firm, sexy rms Wnt toned, strong rms tht crown you pushup queen t oot cmp? Wnt to rock tnk top? These four moves re wht you need. Achieve Totl Arm Envy Mny women zero in on the show-off muscles,
More informationCase Report Surgical Resection of a Leiomyosarcoma of the Inferior Vena Cava Mimicking Hepatic Tumor
Cse Reports in Medicine Volume 2013, Article ID 235698, 5 pges http://dx.doi.org/10.1155/2013/235698 Cse Report Surgicl Resection of Leiomyosrcom of the Inferior Ven Cv Mimicking Heptic Tumor Junji Ued,
More informationSeeding Metastasis of Chromophobe Renal Cell Carcinoma after Robot-Assisted Laparoscopic Partial Nephrectomy
pissn 2384-1095 eissn 2384-1109 imri 2017;21:119-124 https://doi.org/10.13104/imri.2017.21.2.119 Seeding Metstsis of Chromophoe Renl Cell Crcinom fter Root-Assisted Lproscopic Prtil Nephrectomy Knghun
More informationThe potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens
The potentil future of trgeted rdionuclide therpy: implictions for occuptionl exposure? Introduction: Trgeted Rdionuclide Therpy (TRT) Systemic tretment Molecule lbelled with rdionuclide delivers toxic
More informationCopy Number ID2 MYCN ID2 MYCN. Copy Number MYCN DDX1 ID2 KIDINS220 MBOAT2 ID2
Copy Numer Copy Numer Copy Numer Copy Numer DIPG38 DIPG49 ID2 MYCN ID2 MYCN c DIPG01 d DIPG29 ID2 MYCN ID2 MYCN e STNG2 f MYCN DIPG01 Chr. 2 DIPG29 Chr. 1 MYCN DDX1 Chr. 2 ID2 KIDINS220 MBOAT2 ID2 Supplementry
More informationFindings Regarding an Intracranial Hemorrhage on the Phase Image of a Susceptibility-Weighted Image (SWI), According to the Stage, Location, and Size
pissn 2384-1095 eissn 2384-1109 imri 2015;19:107-113 http://dx.doi.org/10.13104/imri.2015.19.2.107 Findings Regrding n Intrcrnil Hemorrhge on the Phse Imge of Susceptiility-Weighted Imge (SWI), According
More informationEfficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis
Efficcy of Pembrolizumb in Ptients With Advnced Melnom With Stble Brin Metstses t Bseline: A Pooled Retrospective Anlysis Abstrct 1248PD Hmid O, Ribs A, Dud A, Butler MO, Crlino MS, Hwu WJ, Long GV, Ancell
More informationT.S. Kurki a, *,U.Häkkinen b, J. Lauharanta c,j.rämö d, M. Leijala c
Europen Journl of Crdio-thorcic Surgery 20 (2001) 1183 1187 www.elsevier.com/locte/ejcts Evlution of the reltionship between preopertive risk scores, postopertive nd totl length of stys nd hospitl costs
More informationEffect of 1-Methylcyclopropene on the Physiology and Yield of Cotton. Derrick Oosterhuis Eduardo Kawakami and Dimitra Loka University of Arkansas
Effect of 1-Methylcyclopropene on the Physiology nd Yield of Cotton Derrick Oosterhuis Edurdo Kwkmi nd Dimitr Lok University of Arknss Cotton Crop Gossypium hirsutum Unique out cotton Perennil grown s
More informationFluoroscopy Guided Percutaneous Transpedicular Biopsy for Thoracic and Lumbar Vertebral Body Lesion: Technique and Safety in 23 Consecutive Cases.
Fluoroscopy Guided Percutneous Trnspediculr Biopsy for Thorcic nd Lumr Verterl Body Lesion: Technique nd Sfety in 23 Consecutive Cses. Shresth D, Shresth R, Dhoju D ABSTRACT Bckground Deprtment of Orthopedic
More informationAgilent G6825AA MassHunter Pathways to PCDL Software Quick Start Guide
Agilent G6825AA MssHunter Pthwys to PCDL Softwre Quick Strt Guide Wht is Agilent Pthwys to PCDL? Fetures of Pthwys to PCDL Agilent MssHunter Pthwys to PCDL converter is stnd-lone softwre designed to fcilitte
More informationReducing the Risk. Logic Model
Reducing the Risk Logic Model ETR (Eduction, Trining nd Reserch) is nonprofit orgniztion committed to providing science-bsed innovtive solutions in helth nd eduction designed to chieve trnsformtive chnge
More informationImaging-guided Percutaneous Large-Bore Suprapubic Cystostomy, a Safe Bladder Diversion Alternative AJIR
CASE SERIES Imging-guided Percutneous Lrge-Bore Suprpuic Cystostomy, Sfe Bldder Diversion Alterntive Jesse Chen 1, Elliot Lndu 2, Noor Ahmd 2, Christopher Giordno 2, Jonthn Scheiner 2, Nchum Ktlowitz 3,
More informationComparative effectiveness of the tumour diagnostics,
Gut, 1987, 28, 323-329 Comprtive effectiveness of the tumour dignostics, C 19-9, C 125 nd crcinoembryonic ntigen in ptients with diseses of the digestive system K SKMOTO, Y HG, R YOSHIMR, H GMI, Y YOKOYM,
More informationCommunication practices and preferences between orthodontists and general dentists
Originl rticle ommuniction prctices nd preferences between orthodontists nd generl dentists Kevin ibon ; hvn Shroff b ; l M. est c ; Steven J. Linduer d STRT Objective: To evlute similrities nd differences
More informationInvasive Pneumococcal Disease Quarterly Report. July September 2017
Invsive Pneumococcl Disese Qurterly Report July September 2017 Prepred s prt of Ministry of Helth contrct for scientific services by Rebekh Roos Helen Heffernn October 2017 Acknowledgements This report
More informationInfluence of lateral cephalometric radiography in orthodontic diagnosis and treatment planning
Originl Article Influence of lterl cephlometric rdiogrphy in orthodontic dignosis nd tretment plnning An Reis Durão ; Ali Alqerbn b ; Afonso Pinhão Ferreir c ; Reinhilde Jcobs d ABSTRACT Objective: To
More informationCase Report Acute Zonal Occult Outer Retinopathy with Atypical Findings
Cse Reports in Medicine Volume 24, Article ID 29696, 7 pges http://dx.doi.org/.55/24/29696 Cse Report Acute Zonl Occult Outer Retinopthy with Atypicl Findings Dimitrios Krginnis, Georgios A. Kontdkis,
More informationProducts for weaners Benzoic acid or the combination of lactic acid and formic acid
Products for weners Benzoic cid or the comintion of lctic cid nd formic cid Tril report no.: 490 Novemer, 000 Hnne Mrio, Lrs Egelund Olsen, Bent Borg Jensen 1 nd Nuri Miquel 1 The Ntionl Committee for
More information(Received for publication February 17, 1944) Since, as has been demonstrated by Enders (3),
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XII. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PREVENTION
More informationAnalysis of alternatives for insulinizing patients to achieve glycemic control and avoid accompanying risks of hypoglycemia
284 Anlysis of lterntives for izing ptients to chieve glycemic control nd void ccompnying risks of hypoglycemi JIALIN GAO 1,2*, QIANYIN XIONG 1,2*, JUN MIAO 1*, YAO ZHANG 2,3, LIBING XIA 1, MEIQIN LU 1,
More informationMagnetic Resonance Imaging (MRI) in Syringomyelia
Act Neurochir (Wien)(1995) 134:93-99 :Act. _ N urochlrurgc 9 Springer-Verlg t995 Printed in Austri Mgnetic Resonnce Imging (MRI) in Syringomyeli H. L. J. Tnghe Deprtment of Rdiodignostics, University Hospitl
More informationMassive Pulmonary Embolism Thrombolysis: Early Clinical Markers of Treatment Efficacy
Originl Article 17 Mssive Pulmonry Emolism Thromolysis: Erly Clinicl Mrkers of Tretment Efficcy Elie Portnoy 1 Vihor Wdhw 2 Mrin de Crvlho Bros 3 Clifford R. Weiss 1 Brin Holly 1 Mrk L. Lessne 1,4 Kelvin
More informationEffect on Glycemic, Blood Pressure, and Lipid Control according to Education Types
Originl Article http://dx.doi.org/10.4093/dmj.2011.35.6.580 pissn 2233-6079 eissn 2233-6087 D I A B E T E S & M E T A B O L I S M J O U R N A L Effect on Glycemic, Blood Pressure, nd Lipid Control ccording
More informationOpioid Use and Survival at the End of Life: A Survey of a Hospice Population
532 Journl of Pin nd Symptom Mngement Vol. 32 No. 6 December 2006 NHPCO Originl Article Opioid Use nd Survivl t the End of Life: A Survey of Hospice Popultion Russell K. Portenoy, MD, Un Sibircev, BA,
More information308 nm excimer lamp in combination with topical tacrolimus: A retrospective study of its efficacy and safety in childhood vitiligo
ORIGINAL ARTICLE 308 nm excimer lmp in comintion with topicl tcrolimus: A retrospective study of its efficcy nd sfety in childhood vitiligo BS Chndrshekr, N Shoh, P Deprtment of Dermtology, Cutis, Acdemy
More informationTales of the Unexpected: Incidental Findings in Ophthalmic Imaging
62 The Journl of Ophthlmic Photogrphy Volume 35, Numer 2 Fll 2013 ORIGINAL ARTICLE Angel J Chppell B.App.Sci, CRA, OCT-C Jmie E Crig MBBS(hons), D.Phil., FRANZCO Ophthlmology Deprtment Flinders Medicl
More informationImpact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting
Impct of Phrmcist Intervention on Dibetes Ptients in n Ambultory Setting Julie Stding, PhrmD, CDE, Jmie Herrmnn, PhrmD, Ryn Wlters, MS, Chris Destche, PhrmD, nd Aln Chock, PhrmD Dibetes is the seventh-leding
More informationDebra A. Ignaut, R.N., B.S., C.D.E., and Haoda Fu, Ph.D.
Journl of Dietes Science nd Technology Volume 6, Issue 2, Mrch 2012 Dietes Technology Society TECHNOLOGY REPORT Comprison of Insulin Diluent Lekge Postinjection Using Two Different Needle Lengths nd Injection
More informationSuccessful Diagnosis of a Thymoma by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: A Report of Two Cases
CASE REPORT Successful Dignosis of Thymom y Endoronchil Ultrsound-guided Trnsronchil Needle Aspirtion: A Report of Two Cses Ysushi Yoshid 1, Msto Singyoji 1, Hironori Ashinum 1, Meiji Itkur 1, Toshihiko
More informationComparison of three simple methods for the
J. clin. Pth. (1967), 2, 5 Comprison of three simple methods for the ssessment of 'free' thyroid hormone T. M. D. GIMLETTE1 From the Rdio-Isotope Lbortory, St. Thoms's Hospitl, London SYNOPSIS A dilysis
More informationCheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer
CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn
More information