Evaluating the CT Diagnosis of Clostridium difficile Colitis: Should CT Guide Therapy?

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1 Iain D. C. Kirkpatrick 1 Howard M. Greenberg Received April 7, 2000; accepted after revision August 24, Both authors: Department of Radiology, University of Manitoba, Health Sciences Centre, 820 Sherbrook St., Winnipeg, Manitoba R3A 1R9, Canada. Address correspondence to I. D. C. Kirkpatrick. AJR 2001;176: X/01/ American Roentgen Ray Society Evaluating the CT Diagnosis of Clostridium difficile Colitis: Should CT Guide Therapy? OBJECTIVE. The purpose of this study was to further characterize the CT findings of Clostridium difficile colitis and to provide for the first time a diagnostic sensitivity, specificity, positive predictive value, and negative predictive value to help clinicians decide whether antibiotic treatment is warranted on the basis of CT findings while awaiting stool test results (which may take as long as 48 hr). MATERIALS AND METHODS. A retrospective review covering a 4-year period was performed of the charts and CT scans of 54 symptomatic patients with stool test results positive for C. difficile and of a control group of 56 patients with antibiotic-associated diarrhea with stool test results negative for C. difficile. RESULTS. At our institution, C. difficile colitis was explicitly diagnosed at CT in these patients with a sensitivity of 52%, specificity of 93%, positive predictive value of 88%, and negative predictive value of 67%. The sensitivity can be raised to 70% with no change in specificity with more rigid adherence to diagnostic criteria of colon wall thickening of greater than 4 mm combined with any one or more findings of pericolonic stranding, colon wall nodularity, the accordion sign, or otherwise unexplained ascites. CONCLUSION. Although routine CT screening of antibiotic-associated diarrhea is not advocated, the 88% positive predictive value of a diagnosis of C. difficile colitis in those who are scanned may merit consideration of treatment by clinicians on the basis of the CT results alone. A ntibiotic-associated diarrhea is a common problem, causing significant morbidity to patients. Although many cases have no determined infectious cause and are self-limited, a large number are due to the gram-positive anaerobe Clostridium difficile. C. difficile colitis is a condition in which an insult to normal gut flora within the previous 6 weeks, most commonly caused by antibiotics or chemotherapeutic agents, allows colonization of the colon by the organism and production of its characteristic toxins, A and B. These toxins have both cytotoxic and enterotoxic effects and produce a spectrum of clinical findings ranging from watery diarrhea and abdominal pain to fever, leukocytosis, sepsis, colonic perforation, and death [1 4]. Characteristic pseudomembranes composed of fibrin, inflammatory cells, and cellular debris seen in pathologic gross specimens and at endoscopy have earned this disease the name pseudomembranous colitis [2 4]. The availability of pharmacologic agents to treat this disease makes early diagnosis important in reducing morbidity and mortality. The gold standard for diagnosis is a microbiologic stool assay for C. difficile cytotoxin [1, 3]. Although this test has a high sensitivity and specificity, results are generally not available for 48 hr or longer. Other faster microbiologic assays are available but are not as sensitive [1, 3]. Endoscopy with biopsy has been used to make the diagnosis, but this method is also less sensitive, and mechanical manipulation of a diseased colon puts the patient at risk [2, 3]. CT has been increasingly studied as a noninvasive fast method of making the diagnosis of C. difficile colitis. Several recent articles have described CT findings in patients testing positive for C. difficile colitis on stool assay [4 9]. These CT findings include colonic wall thickening and nodularity, pericolonic stranding and edema, ascites, and the accordion sign, which describes the appearance of oral contrast material trapped between nodular thickened folds of bowel. In the largest study AJR:176, March

2 Kirkpatrick and Greenberg to date, Boland et al. [7] examined 64 patients and found that 85% showed some colonic abnormality on CT. Unfortunately, the most commonly seen abnormality, colonic wall thickening, is nonspecific and can be found in other colitides, although it is thought to be more pronounced in C. difficile colitis than in other causes of colitis [10]. The CT sensitivity and specificity for explicitly diagnosing C. difficile colitis have never been determined, to our knowledge. The purpose of our study was to evaluate for the first time how successfully the diagnosis of C. difficile colitis could be made with CT. We retrospectively reviewed the CT examinations of 54 patients with C. difficile disease and 56 control patients with C. difficile negative antibiotic-associated diarrhea. Materials and Methods The charts of 430 patients with antibiotic-associated diarrhea who tested positive for C. difficile toxin on a stool assay and 261 patients with antibiotic-associated diarrhea who tested negative for for C. difficile toxin were retrospectively reviewed. Between January 1, 1996, and November 1, 1999, 54 of the C. difficile positive group and 56 of the negative group underwent abdominal CT while symptomatic with diarrhea. All patients underwent stool testing within 7 days of CT (median, 1 day after CT). All tests were performed at the same institution. For the purposes of the study, the stool toxin assay was used as the gold standard for diagnosis. We retrospectively reviewed all charts, CT reports from the original time of scanning, and CT scans. We were not blinded to the clinical history or stool assay findings. Scans were examined for evidence of colonic wall thickening (defined as a wall thickness measured with calipers of greater than 4 mm), wall nodularity, pericolonic stranding, ascites (defined as intraperitoneal free fluid collecting in the dependent abdomen), and the accordion sign. The quantitative measurement of wall thickness, distribution of disease throughout the colon, and any coexistent lesions were all noted. At our center, the diagnosis of C. difficile colitis on CT was made at the time of scanning on the basis of a colon wall thickness of greater than 4 mm, a compatible clinical history, and one or more of the following findings: colon wall nodularity, pericolonic stranding, or otherwise unexplained ascites. Equivocal cases, in which the reporting radiologist thought the findings may be present but too subtle to explicitly diagnose C. difficile colitis with confidence, received the diagnosis of a nonspecific colitis. For the purposes of determining sensitivity, specificity, positive predictive value, and negative predictive value of the CT diagnosis of C. difficile at our institution, results used were the diagnoses made at the original time the scans were obtained, as recorded in the patients charts by radiologists blinded to the patient s C. difficile status. Results for the distribution and diagnostic value of CT findings, the findings themselves, and colon wall measurements in both groups were those determined at the time of the retrospective review. CT scans were obtained with one of two helical CT scanners (Somotom-R; Siemens Medical Systems, Iselin, NJ). Our standard axial CT protocol used either an 8- or 10-mm slice thickness and intervals from the diaphragm to the symphysis pubis. All patients were given oral contrast material, but only 74% of the C. difficile positive group and 79% of the control group received IV contrast material. Consequently, no comparisons of wall enhancement or halo effect were made. Results The diagnosis of C. difficile colitis was made in 28 (52%) of the 54 patients with positive stool assays at the time of scanning. In the 56 patients with negative stool assays, the diagnosis was made in four (7%). The results corresponded to a sensitivity of 52%, specificity of 93%, positive predictive value of 88%, and negative predictive value of 67%. Ten patients (19%) from the group with a positive stool assay and one patient (2%) from the negative control group were diagnosed with nonspecific colitis because CT findings were thought to be insufficient to make a more precise diagnosis at the time of scanning. The remaining patients in both groups were either diagnosed with a specific colonic disease other than C. difficile colitis, or the colon was thought to be unremarkable. At review of the CT scans, the distribution of the findings of colon wall thickening (Fig. 1), colon wall nodularity, the accordion sign (Fig. 2), pericolonic stranding, and ascites for the two groups was determined and is shown in Table 1. Of the patients in the assay-positive group with colon wall thickening, the mean thickness was 11 mm (range, 5 25 mm). For patients whose scans showed colon wall thickening, the sensitivity and specificity of each of the aforementioned signs and their combinations for the explicit diagnosis of C. difficile colitis are given in Table 2, as determined at the time of the retrospective review. Given the consensus that wall thickening is often more pronounced in patients with C. difficile colitis than in patients with other colitides, values were calculated first for all patients with colon wall measurements of greater than 4 mm and then for those with a thickness of 10 mm or greater. In the patients with positive stool assay tests who had colon wall thickening, the distribution of the thickening was pancolonic in 17 (41%). Involvement of only the right colon (i.e., no changes beyond the mid transverse colon) was seen in four (10%) of the patients, and left-sided involvement only was seen in 10 (24%). Findings were limited to the cecum in two patients (5%) and to the rectum in two patients (5%). Rectal sparing was seen in 13 patients (32%) and rectosigmoid sparing in nine (22%). The final diagnoses of the four patients with negative stool assays who were diagnosed at the time of scanning with C. difficile colitis were reviewed. Two patients underwent lower endoscopy with biopsy, which revealed cytomegalovirus colitis in one and ulcerative colitis in the other (Fig. 3). One patient was on multiple chemotherapeutic agents and IV antibiotics and was diagnosed clinically with a nonspecific drug induced diarrhea. The fourth patient, who had ab- Fig year-old woman with diarrhea and abdominal pain. Stool assay was positive for Clostridium difficile cytotoxin. Axial CT scan shows grossly thickened descending colon (arrow) with pericolonic stranding (solid arrowhead). Note ascites (open arrowhead) pooling in left paracolic gutter. 636 AJR:176, March 2001

3 CT Diagnosis of Clostridium difficile Colitis A B Fig year-old man with abdominal pain, fever, elevated WBC count, and diarrhea. Stool assay was positive for Clostridium difficile toxin. A, Axial CT scan shows extensive nodular wall thickening (arrows) throughout transverse colon. Lines of high attenuation are from oral contrast material trapped between nodular bowel wall folds that produce accordion sign. B, Axial CT scan through pelvis reveals nodular thickening (arrow) within sigmoid colon. TABLE 1 CT Findings and Stool Assay Results for Clostridium difficile Toxin in 110 Patients with Antibiotic-Associated Diarrhea CT Finding Stool Assay Results Positive (n = 54) Negative (n = 56) No. % No. % Colon wall thickening of greater than 4 mm Colon wall nodularity Accordion sign Pericolonic stranding Ascites TABLE 2 Value of CT Signs in Diagnosing Clostridium difficile Colitis in Patients with Colon Wall Thickening Sign Colon Wall Thickness >4 mm 10 mm Sensitivity (%) Specificity (%) Sensitivity (%) Specificity (%) Wall thickening Pericolonic stranding Ascites Wall nodularity a Pericolonic stranding and ascites Pericolonic stranding and wall nodularity Pericolonic stranding, ascites, and wall nodularity Any one or combination of pericolonic stranding, ascites, or wall nodularity Note. The combination of wall nodularity and ascites in the absence of pericolonic stranding was not seen. a Includes the accordion sign. dominal pain, fever, and diarrhea, never received a formal diagnosis and his symptoms resolved on antibiotic therapy. Of the other control patients with antibioticassociated diarrhea, CT abnormalities of the colon included ischemic colitis, neutropenic enterocolitis, colonic lymphoma, appendicitis, Crohn s disease, and colonic carcinoma. All cases were successfully diagnosed on the basis of clinical history and CT findings, and none was mistaken for C. difficile colitis. The use of IV contrast material caused no significant difference in CT sensitivity, with the diagnosis of C. difficile colitis correctly made at the time of scanning in 20 (50%) of the 40 patients who received IV contrast material and eight (57%) of the 14 who did not (p > 0.50). No significant differences in CT sensitivity could likewise be seen on the basis of the time of CT in relation to the time of stool assay testing. Of C. difficile positive patients scanned within 3 days of stool testing, 23 (51%) of 45 were correctly diagnosed, compared with three (60%) of five scanned more than 3 days before stool testing (p > 0.50), and two (50%) of four scanned more than 3 days after stool testing (p > 0.50). Discussion C. difficile colitis is a serious problem that causes significant morbidity and mortality, but one for which effective treatments exist AJR:176, March

4 Kirkpatrick and Greenberg Fig year-old man with bloody diarrhea and abdominal pain. Stool assay was negative for Clostridium difficile toxin. Note fairly symmetric wall thickening of ascending and descending colon (arrow), with only minimal pericolonic reaction (arrowhead) and no ascites. Although initial diagnosis on CT was C. difficile colitis, endoscopic biopsy showed ulcerative colitis. [3]. The incidence of disease at our institution in 1996 was 38 cases per 100,000 patient days, similar to the average national hospital incidence of and minimally less than the average of 40.3 cases per 100,000 patient days in hospitals of similar size (>500 beds) [11]. Stool test positivity rates at our center are also in line with other Canadian hospitals [11]. Ideally, patients should be treated as soon as possible to avoid progression of disease to the point of frank sepsis or bowel perforation. In many cases in which symptoms are severe, a patient with antibiotic-associated diarrhea undergoes CT of the abdomen before stool testing for C. difficile. To our knowledge, no controlled study exists on how well the diagnosis of C. difficile colitis can be made with CT, and clinicians are unsure of how to proceed when CT suggests the diagnosis. Confirmatory stool testing can be performed, but this may delay treatment by 48 hr or more. Also in question is the utility of CT as a quickly performed screen for the disease. Other studies have suggested that findings on abdominal CT scans may be absent in a significant number of patients [6, 7]. Fishman et al. [6] found that three (12%) of 26 patients with the disease showed no colon wall abnormality. Furthermore, Boland et al. [7] found that 25 (39%) of 64 patients with the disease showed no colonic abnormality. Our study found that at our center the sensitivity of CT for making the diagnosis of C. difficile colitis is 52%. Of the patients with positive findings for C. difficile, 13 (24%) showed no colonic abnormality on CT. Even in those who did show abnormalities, the findings were not always indicative of C. difficile colitis in particular. Clearly, this data suggests that CT would not be a test of choice for screening patients for the disease. That having been said, the specificity of CT was shown to be 93% by our study. Perhaps of more interest to clinicians is the positive predictive value of 88%. In other words, our study found that a patient who received a diagnosis of C. difficile colitis on the basis of a CT scan had an 88% probability of testing positive on a stool assay. We believe that given this finding, it would be reasonable to consider initiating treatment based on the CT results alone, while a stool assay for confirmation is pending. In our chart review, only one case could be found in which antibiotic therapy was initiated on the basis of the CT diagnosis. In examining the individual CT findings of the disease, our findings are similar to those described in previous studies with some exceptions [5 7]. The accordion sign was found in only 4% of our patients, compared with 19% in the study by Fishman et al. [6]. However, Boland et al. [7] found the sign in 5% of their patients, which resembles our findings. Ascites was also seen in a significantly higher number of our patients (52%) than those in the study by Boland et al., in which it was seen in only 17% of the patients. One contributing factor to this discrepancy is that six of the 28 C. difficile positive patients in our study who showed ascites had other findings seen on CT that could explain the free fluid: cirrhosis (two patients), pancreatitis (two patients), and metastatic ovarian carcinoma (two patients). Five of these patients had no other findings to suggest C. difficile colitis and represented false-negative diagnoses. Likewise, six patients in the control group who had ascites had clear coexistent diseases shown on CT that could explain this finding. Even taking these factors into account, the percentage of patients with C. difficile colitis who had ascites remains significantly higher (41%). Other possible explanations could include the imaging of patients in our study at a more advanced point in the disease, on average, or perhaps patients who are more prone to ascites to begin with be it caused by malnutrition or chronic disease (many patients imaged in our study were sent from either the intensive care unit or the oncology ward). Our study is similar to that performed by Boland et al. [7] in that although colon wall thickening was the most sensitive abnormality in C. difficile colitis, other findings such as wall nodularity, the accordion sign, and ascites were more specific. Wall thickening is the key CT finding in this disease, and, except for the five patients who showed ascites explained by other coexistent diseases on their scans, all the patients in the group with positive assay results showing any abnormality suggestive of C. difficile had thickened colon walls. As Table 2 shows, once colon wall thickening is identified, the ancillary findings of pericolonic stranding, ascites, and colon wall nodularity (including the accordion sign) increase the specificity of the diagnosis for C. difficile, with additive effects. A wall thickness of 10 mm or greater is by itself a specific finding for C. difficile colitis, but not a sensitive one. The combination of wall thickening of greater than 4 mm and any one or more of the ancillary findings described in Table 2 provides criteria that are still specific but that have a significantly increased sensitivity. At our center, the criteria used for diagnosis by our radiologists (based on prior studies) over the last 4 years have been a colon wall thickness of greater than 4 mm in conjunction with any findings of wall nodularity, the accordion sign, pericolonic stranding, or unexplained ascites [6, 7, 10]. In fact, on review these criteria were not always used. If these criteria had been rigidly applied, 10 patients initially diagnosed with nonspecific colitis would have been correctly labeled by CT as having C. difficile colitis. The sensitivity and specificity in this case would have, in fact, been 70% and 93%, respectively, with a positive predictive 638 AJR:176, March 2001

5 CT Diagnosis of Clostridium difficile Colitis value of 90% and negative predictive value of 76%. Using the criteria of either a wall thickness of 10 mm or greater or a wall thickness of greater than 4 mm and any of the more specific findings does not add significantly to the diagnosis based on our data (sensitivity, 72%; specificity, 91%) but gives equally satisfactory results. Of the 16 patients with positive stool assays who were not initially diagnosed with either C. difficile or nonspecific colitis, three patients showed colon wall thickening only, which was missed at the original time of scanning. The remaining 13 patients showed none of the previously described findings on their scans. The most likely explanation is that there is a spectrum of findings in this disease, and these patients were imaged before the disease was significant enough to show radiographic changes. Unlike CT, a stool assay for toxin is not as dependent on the severity and length of illness [1]. There are a number of limitations to our study. Patients imaged were predominantly those who showed more marked clinical symptoms, including abdominal pain, fever, and signs of sepsis. Many patients with diarrhea alone did not undergo diagnostic imaging. The sensitivity shown in our study is, therefore, likely more representative of testing in patients with more advanced disease. Results of our study are also representative of the radiologists in our CT department and could, thus, be expected to vary from center to center. This is compounded by the lack of clear CT diagnostic criteria for C. difficile colitis in the literature to date. Finally, we are using the stool cytotoxin assay as the microbiologic gold standard, and no allowance was made for microbiologic misdiagnosis. In conclusion, we found that at our center the CT diagnosis of C. difficile colitis was made with a sensitivity of 52%, specificity of 93%, positive predictive value of 88%, and negative predictive value of 67%. Although the sensitivity is not satisfactory for screening purposes, the positive predictive value is impressive. Sensitivity could have been improved to 70% with no change in specificity by adhering strictly to diagnostic guidelines of colon wall thickness of greater than 4 mm in conjunction with any one or more findings of colon wall nodularity, the accordion sign, pericolonic stranding, or otherwise unexplained ascites. We suggest that patients with antibiotic-associated diarrhea who have CT findings diagnostic of C. difficile colitis merit consideration for treatment on that basis. Acknowledgments We thank John Embil and Debbie Nichol of the Infection Control Department of the Winnipeg Health Sciences Centre for their assistance in providing stool assay data. References 1. Knoop FC, Owens M, Crocker IC. Clostridium difficile: clinical disease and diagnosis. Clin Microbiol Rev 1993;6: Counihan TC, Roberts PL. Pseudomembranous colitis. Surg Clin North Am 1993;5: Surawicz CM, McFarland LV. Pseudomembranous colitis: causes and cures. Digestion 1999;60: Ros PR, Buetow PC, Pantograg-Brown L, Forsmark CE, Sobin LH. Pseudomembranous colitis. Radiology 1996;198: Merine DS, Fishman EK, Jones B. Pseudomembranous colitis: CT evaluation. J Comput Assist Tomogr 1987;2: Fishman EK, Kavuru M, Jones B, et al. Pseudomembranous colitis: CT evaluation of 26 cases. Radiology 1991;180: Boland GW, Lee MJ, Cats AM, Gaa JA, Saini S, Mueller PR. Antibiotic-induced diarrhea: specificity of abdominal CT for the diagnosis of Clostridium difficile disease. Radiology 1994; 191: Blickman JG, Boland GWL, Cleveland RH, Bramson RT, Lee MJ. Pseudomembranous colitis: CT findings in children. Pediatr Radiol 1995; 25[suppl]:S157 S O Sullivan SG. The accordion sign. Radiology 1998;206: Philpotts LE, Heicken JP, Westcott MA, Gore RM. Colitis: use of CT findings in differential diagnosis. Radiology 1994;190: Alfa MJ, Du T, Beda G. Survey of incidence of Clostridium difficile infection in Canadian hospitals and diagnostic approaches. J Clin Microbiol 1998;36: AJR:176, March

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