Curriculum Vitae: PD Dr. med. Burkhard Pleger

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1 Curriculum Vitae: PD Dr. med. Burkhard Pleger Born July 15, 1970, D Münster (State of North Rhine-Westfalia, Germany) German Citizen, Married to Sonja Sellenmerten, One daughter: Linn Sophie Sellenmerten Currently held position Research Group Leader, Consultant (Oberarzt) Address (work) Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Stephanstr. 1A, Leipzig, Germany Tel FAX bpleger@cbs.mpg.de Address (Private) Wolfgang-Heinze-Str. 41, 0477 Leipzig, Germany Mobile Education and Training Education Elementary school, Münster High School, Münster High School, Gaienhofen, Lake of Constance, Graduation (Abitur) School for radiographers, Heidelberg Medical School, Ruhr-University M.D. Professional Resident, Neurology, Dept. Neurology, Ruhr-University (Director: Prof. Dr. J.-P. Malin) Medical Computer Scientist, MIBEG Institute Cologne Two year fellowship at Wellcome Trust Centre of Neuroimaging, Institute of Neurology, University College London, UK (Director and Supervisor: Prof. Dr. R.J. Dolan) 006 Board Exam, Neurology 007 Resident, Neurology, Dept. Neurology, University Duisburg- (Director: Prof. Dr. H.C. Diener) Habilitation at University Duisburg Research Group Leader, Consultant (Oberarzt), Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig (Director: Prof. Dr A. Villringer)

2 Memberships Deutsche Gesellschaft für Neurologie (German Neurological Society) Society for Neuroscience Reviewer Activities Peer Review Journals: Current Bilology, Brain, Journal of Neuroscience, Archives of Neurology, Neuroreport, Annals of Neurology, Brain Stimulation, Clinical Neurophysiology, Experimental Brain Research, Neuroscience Letters, European Journal of Neuroscience, Journal of Clinical Psychopharamcolgy, Journal of Pain, Pain, Neuroimage, Neurology, Neuroscience, Human Brain Mapping, Cerebral Cortex Editorial Activities Editorial Board Member: Frontiers Journal Series Funding / Grants Project Funding agency PI Duration Sum ( ) Functional Imaging of plasticity in Forschungsförderung, Pleger human somatosensory cortex BG-Kliniken Bergmannsheil, Improvement of cognition and tactile FoRUM of Ruhr- Pleger/Brüne discrimination in Alzheimer dementia using repetitive transcranial stimulation University Learning-dependent versus stimulationinduced plasticity and its consolidation in the human somatosensory system BMBF - Bernstein Fokus Learning Pleger

3 Publications 1) Dissertation: Pleger 1998 Inaugural-Dissertation, Prof. Dr. H.K. Beyer at Dept. Radiology, Ruhr-University Detection of liver lesions: magnetic resonance imaging using superparamagnetic iron particles (AMI-5, Endorem) as a contrast agent in comparison with ultrasound, computer tomography and CT portography. ) Habilitation: Pleger 007 Habilitationsschrift University Duisburg- Reorganisation of human somatosensory cortex. Peer-Review Articles [impact factor] 1. Pleger B, Dinse HR, Ragert P, Schwenkreis P, Malin JP, Tegenthoff M (001) Shifts in cortical representations predict human discrimination improvement. Proc. Natl. Acad. Sci. U S A 98: [10.700]. Pleger B, Beyer HK, Laufer U (001) Detection of liver lesions: magnetic resonance tomography using superparamagnetic iron particles (AMI-5, endorem) as a contrast medium in comparison with ultrasound diagnosis, computerized tomography and CT portography. Röntgenpraxis 53: Schwenkreis P, Pleger B, Höffken O, Malin JP, Tegenthoff M (001) Repetitive training of a synchronised movement induces short-term plastic changes in the human primary somatosensory cortex. Neurosci. Lett. 31: [1.898] 4. Schwenkreis P, Witscher K, Janssen F, Pleger B, Dertwinkel R, Zenz M, Malin JP, Tegenthoff M (001) Assessment of reorganization in the sensorimotor cortex after upper limb amputation. Clin. Neurophysiol. 11: [.64] 5. Pleger B, Foerster A-F, Ragert P, Dinse HR, Schwenkreis P, Malin JP, Nicolas V, Tegenthoff M (003) Functional imaging of perceptual learning in human primary and secondary somatosensory cortex. Neuron 40: [14.304] 6. Pleger B, Foerster AF, Widdig W, Henschel M, Nicolas V, Jansen A, Frank A, Knecht S, Schwenkreis P, Tegenthoff M (003) Functional magnetic resonance imaging mirrors recovery of visual perception after repetitive tachistoscopic stimulation in patients with partial cortical blindness. Neurosci. Lett. 335: [1.898] 3

4 7. Pleger B, Schwenkreis P, Dinse HR, Ragert P, Höffken O, Malin JP, Tegenthoff M (003) Pharmacological suppression of plastic changes in human primary somatosensory cortex after motor learning. Exp. Brain. Res. 148: [.118] 8. Dinse HR, Ragert P, Pleger B, Schwenkreis P, Tegenthoff M (003) Pharmacological modulation of perceptual learning and associated cortical reorganization. Science 301: [ 30.97] 9. Schwenkreis P, Janssen F, Rommel O, Pleger B, Völker B, Hosbach I, Dertwinkel R, Maier C, Tegenthoff M (003) Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand. Neurology 61: [4.947] 10. Ragert P, Dinse HR, Pleger B, Wilimzig C, Frombach E, Schwenkreis P, Tegenthoff M (003) Combination of 5 Hz repetitive transcranial magnetic stimulation (rtms) and tactile coactivation boosts tactile discrimination in humans. Neurosci. Lett. 348: [1.898] 11. Schwenkreis P, Pleger B, Cornelius B, Weyen U, Dertwinkel R, Zenz M, Malin JP, Tegenthoff M (003) Reorganization in the ipsilateral motor cortex of patients with lower limb amputation. Neurosci. Lett. 349: [1.898] 1. Schwenkreis P, Maier C, Pleger B, Mansourian N, Dertwinkel R, Malin JP, Tegenthoff M, Zenz M (003) NMDA-mediated mechanisms in cortical excitability changes after limb amputation. Acta. Neurol. Scand. 108: [1.98] 13. Dinse HR, Ragert P, Pleger B, Schwenkreis P, Tegenthoff M (003) GABAergic mechanisms gate tactile discrimination learning. Neuroreport 14: [1.995] 14. Widdig W, Pleger B, Rommel O, Malin, JP, Tegenthoff M (003) Repetitive visual stimulation: a neurophysiological approach to the treatment of cortical blindness. NeuroRehabilitation 18: 7-37 [1.558] 15. Pleger B, Tegenthoff M, Schwenkreis P, Janssen F, Ragert P, Dinse HR, Voelker B, Zenz M, Maier C (004) Mean sustained pain levels are linked to hemispherical side-to-side differences in the complex regional pain syndrome I. Exp Brain Res. 155: [.118] 16. Pleger B, Janssen F, Schwenkreis P, Voelker B, Maier C, Tegenthoff M (004) Repetitive transcranial magnetic stimulation of the motor cortex attenuates pain perception in complex regional pain syndrome I. Neurosci. Lett. 356(): [1.898] 17. Ragert P, Becker M, Tegenthoff M, Pleger B, Dinse HR (004) Sustained increase of somatosensory cortex excitability by 5 Hz repetitive transcranial magnetic stimulation studied by paired madian nerve stimulation in humans. Neurosci. Lett. 356(): [1.898] 18. Tegenthoff M, Cornelius B, Pleger B, Malin JP, Schwenkreis P (004) Amphetamine enhances traininginduced motor cortex plasticity. Acta Neurol. Scand. 109 (5): [1.98] 4

5 19. Pleger B, Schwenkreis P, Grünberg C, Malin JP, Tegenthoff M (004) Fluoxetine facilitates usedependent excitability of human primary motor cortex. Clin. Neurophysiol. 115: [.64] 0. Drager B, Jansen A, Bruchmann S, Forster AF, Pleger B, Zwitserlood P, Knecht S (004) How does the brain accommodate to increased task difficulty in word finding? A functional MRI study. NeuroImage. 3(3): [5.88] 1. Schwenkreis P, Witscher K, Pleger B, Malin JP, Tegenthoff M (005) The NMDA antagonist memantine affects training induced motor cortex plasticity - a study using transcranial magnetic stimulation. BMC Neurosci. 6(1):35. [.733]. Tegenthoff M, Ragert P, Pleger B, Schwenkreis P, Förster AF, Nicolas V, Dinse HR (005) Improvement of tactile performance and enlargement of cortical somatosensory maps after 5 Hz rtms. PLoS Biol. 3(11):e36. [14.67] 3. Pleger B, Blankenburg F, Bestmann S, Ruff C, Wiech K, Stephan KE, Friston K, Dolan R (006) Repetitive transcranial magnetic stimulation-induced changes in sensorimotor coupling parallel improvements of somatosensation in humans. J. Neurosci. 6(7): [7.506] 4. Pleger B, Ragert P, Schwenkreis P, Forster A-F, Wilimzig C, Dinse H, Nicolas V, Maier C, Tegenthoff M (006) Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in Complex Regional Pain Syndrome. NeuroImage. 3(): [5.88] 5. Pleger B, Ruff C, Blankenburg F, Bestmann S, Wiech K, Stephan KE, Capilla A, Friston K, Dolan R (006) Neural encoding of tactile decisions in human prefrontal cortex. J. Neurosci. 6(48): [7.506] 6. Wiech K, Kalisch R, Weiskopf N, Pleger B, Stephan KE, Dolan RJ (006) Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over pain. J. Neurosci. 6(44): [7.506] 7. Schwenkreis P, El Tom S, Ragert P, Pleger B, Tegenthoff M, Dinse HR (007) Assessment of sensorimotor cortical representation asymmetries and motor skills in violoine players. Eur. J. Neurosci. 6(11): [3.949] 8. Pleger B, Blankenburg F, Ruff C, Driver J, Dolan R (008) Reward facilitates tactile judgments and modulates hemodynamic responses in human primary somatosensory cortex. J. Neurosci. 8(33): [7.506] 9. Petrovic P, Pleger B, Seymour B, Klöppel S, De Martino B, Critchley H, Dolan R (008) Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses. J. Neurosci. 8(4): [7.506] 5

6 30. Lissek S, Wilimzig C, Stude P, Pleger B, Kalisch T, Maier C, Peters SA, Nicolas V, Tegenthoff M, Dinse HR (009) Immobilization Impairs Tactile Perception and Shrinks Somatosensory Cortical Maps. Curr. Biol. 19(10): [10.539] 31. Obermann M, Pleger B, de Greiff A, Stude P, Kaube H, Diener HC, Katsarava Z (009) Temporal summation of trigeminal pain in human anterior cingulate cortex.. NeuroImage 46(1): [5.88] 3. Pleger B, Ruff CC, Blankenburg F, Klöppel S, Driver J, Dolan R (009) Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making. PLoS. Biol. 7(7): e [13.500] 33. Schneider SA*, Pleger B*, Draganski B, Cordivari C, Rothwell JC, Bhatia KP, Dolan RJ (010) Modulatory effects of 5Hz rtms over the primary somatosensory cortex in focal dystonia-an fmri-tms study. Mov. Disord. 5(1): [3.898] (*contributed equally) 34. Lohmann G, Margulies DS, Horstmann A, Pleger B, Lepsien J, Goldhahn D, Schloegl H, Stumvoll M, Villringer A, Turner R (010) Eigenvector centrality mapping for analyzing connectivity patterns in FMRI data of the human brain. PLoS One 5(4):e103. [4.8] Brief Communications [impact factor] 35. Pleger B, Tegenthoff M, Ragert P, Förster AF, Dinse H, Schwenkreis P, Nicolas V, Maier C (005) Sensorimotor retuning in compex regional pain syndrome parallels pain reduction. Ann. Neurol. 57: [7.571] Case Reports [impact factor] 36. Ossege LM, Postler E, Pleger B, Muller KM, Malin JP (000) Neoplastic cells in the cerebrospinal fluid in intravascular lymphomatosis. J. Neurol. 47: [.844] 37. Pleger B, Foerster A-F, Schwenkreis P, Nicolas V, Malin JP, Frettloeh J, Maier C, Tegenthoff M (004) Untersuchung von Visusstörungen beim Tolosa-Hunt-Syndrom mittels der funktionellen Magnetresonanztomographie zur Abgrenzung psychogener Störungen ein Fallbericht [Functional imaging of the visual cortex in the tolosa-hunt-syndrome for the detection of a psychogenic disorder a case-report]. Schmerz. 18(3): [0.681] 6

7 Reviews 38. Pleger B, Ragert P (006) Pharmacological support of Neurorehabilitation. Curr. Drug Therapy. 1: Pleger B, Tegenthoff M, Dinse HR, Ragert P, Schwenkreis P (005) Pharmacology of motor and somatosensory skills in humans. Curr. Neuropharmacology. 3: Dinse HR, Kalisch T, Ragert P, Pleger B, Schwenkreis P, Tegenthoff M (005) Improving human haptic performance in normal and impaired human populations through unattended activationbased learning. Transactions on Applied Perception. : Teaching Semester Course Place Hrs/ Week SS 99 WS 99/000 SS 000 WS 000/01 SS 01 WS 01/0 SS 0 WS 0/03 SS 03 WS 03/04 SS 04 SS 0 SS 03 SS 04 Functional imaging in Neurology Functional imaging in Neurology Functional imaging in Neurology WS 07/08 WS 07/08 SS 08 WS 08/09 SS 09 WS 09/10 Course in Neurology/Neurological examination Headache Colloquium 3 6 7