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1 This is a Sample version of the Irritable Bowel Syndrome Quality Of Life (IBS-QOL) - The full version of Irritable Bowel Syndrome - Quality Of Life (IBS-QOL) comes without sample watermark.. The full complete 21 page version includes IBS-QOL Overview information IBS-QOL Scoring/ Administration instructions IBS-QOL Complete Q uestionnaire/ Assessment ( 34 sets of question criteria) IBS-QOL Clinical Validity Buy full version here - for $7.00 Clicking the above buy now button will take you to the PayPal payment service website in which you can pay via credit card or your optional PayPal account. Once you have paid for your item you will receive a direct link to download your full complete e-book instantly. You will also receive an with a link to download your e-book. Each purchased product you order is available to download for 24 hours from time of purchase. Should you have any problems or enquiries please contact - info@agedcaretests.com

2 Evaluation of the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire in diarrheal-predominant irritable bowel syndrome patients David A Andrae 1*, Donald L Patrick 2, Douglas A Drossman 3 and Paul S Covington 1 Abstract Background: Diarrhea-predominant irritable bowel syndrome (IBS-d) significantly diminishes the health-related quality of life (HRQOL) of patients. Psychological and social impacts are common with many IBS-d patients reporting comorbid depression, anxiety, decreased intimacy, and lost working days. The Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire is a 34-item instrument developed and validated for measurement of HRQOL in non-subtyped IBS patients. The current paper assesses this previously-validated instrument employing data collected from 754 patients who participated in a randomized clinical trial of a novel treatment, eluxadoline, for IBS-d. Methods: Psychometric methods common to HRQOL research were employed to evaluate the IBS-QOL. Many of the historical analyses of the IBS-QOL validations were used. Other techniques that extended the original methods were applied where more appropriate for the current dataset. In IBS-d patients, we analyzed the items and substructure of the IBS-QOL via item reduction, factor structure, internal consistency, reproducibility, construct validity, and ability to detect change. Results: This study supports the IBS-QOL as a psychometrically valid measure. Factor analyses suggested that IBS-specific QOL as measured by the IBS-QOL is a unidimensional construct. Construct validity was further buttressed by significant correlations between IBS-QOL total scores and related measures of IBS-d severity including the historically-relevant Irritable Bowel Syndrome Adequate Relief (IBS-AR) item and the FDA s Clinical Responder definition. The IBS-QOL also showed a significant ability to detect change as evidenced by analysis of treatment effects. A minority of the items, unrelated to the IBS-d, performed less well by the standards set by the original authors. Conclusions: We established that the IBS-QOL total score is a psychometrically valid measure of HRQOL in IBS-d patients enrolled in this study. Our analyses suggest that the IBS-QOL items demonstrate very good construct validity and ability to detect changes due to treatment effects. Furthermore, our analyses suggest that the IBS-QOL items measure a univariate construct and we believe further modeling of the IBS-QOL from an item response theory (IRT) approach under both non-treatment and treatment conditions would greatly further our understanding as item-based methods could be used to develop a short form. Keywords: IBS-QOL, Patient-reported Outcomes, Psychometrics, HRQOL, Irritable Bowel Syndrome, Diarrhea, Eluxadoline This is the end of the SAMPLE IBS-QOL clinical validity.

3 What is the IBS-QOL? The Irritable Bowel Syndrome-Quality of Life Measure (IBS-QOL) Scoring and Administration The IBS-QOL is a self-report quality-of-life measure specific to Irritable Bowel Syndrome (IBS) that can be used to assess the impact of IBS and its treatment. The IBS-QOL was developed using a needs based model. How is the IBS-QOL administered? The IBS-QOL is designed to be self-administered, and takes an average of 10 minutes to complete. The IBS-QOL can be interviewer-administered if necessary. How is the IBS-QOL scored? The individual responses to the 34 items are summed and averaged for a The transformation formula used for the IBS-QOL total and scale scores is: There are also eight subscale scores for the IBS-QOL (Dysphoria, Interference with Activity, Body Image, Health Worry, Food Avoidance, Social Reaction, Sexual, Relationships). See the below table for IBS-QOL questions categorized in to their specific domains:- Domain Name Question Numbers Dysphoria 1, 6, 7, 9, 10, 13, 30 Interference with Activity 3, 18, 19, 22, 27, 29, 31 Body Image Health Worry s This is the end of the SAMPLE IBS-QOL scoring instructions.

4 PLEASE WRITE IN TODAY'S DATE: MONTH DAY YEAR PARTICIPANT ID: PLEASE READ THIS CAREFULLY ON THE FOLLOWING PAGES YOU WILL FIND STATEMENTS CONCERNING BOWEL PROBLEMS (IRRITABLE BOWEL SYNDROME) AND HOW THEY AFFECT YOU. FOR EACH STATEMENT, PLEASE CHOOSE THE RESPONSE THAT APPLIES BEST TO YOU AND CIRCLE THE NUMBER OF YOUR RESPONSE. IF YOU ARE UNSURE ABOUT HOW TO RESPOND TO A STATEMENT, PLEASE GIVE THE BEST RESPONSE YOU CAN. THERE ARE NO RIGHT OR WRONG RESPONSES. YOUR RESPONSES WILL BE KEPT STRICTLY CONFIDENTIAL. IF YOU HAVE ANY QUESTIONS, PLEASE CONTACT: **SITE ADDRESS AND PHONE NUMBER TO BE PLACED HERE**

5 About how you feel Please think about your life over the past month (last 30 days), and look at the statements below. Each statement has five different responses. For each statement, please circle the response that best describes your feelings. Q1. I feel helpless because of my bowel problems. (Please circle one number) Q2. I am embarrassed by the smell caused by my bowel problems. (Please circle one number) Q3. I am bothered by how much time I spend on the toilet. (Please circle one number) 5 A GREAT DEAL Q4. I feel vulnerable to other illnesses because of my bowel problems. (Please circle one number) This is the end of the SAMPLE IBS-QOL questionnaire.