AIMS FELLOWSHIP CURRICULUM TS I TRANSFUSION SCIENCE Core Module

Size: px
Start display at page:

Download "AIMS FELLOWSHIP CURRICULUM TS I TRANSFUSION SCIENCE Core Module"

Transcription

1 Module Code: TS 1 Module Title: Module Convenor: Patient Based Transfusion Science Dr T Cobain Discipline Committee: Ms Dianne Grey Dr D Roxby Ms D Stern Date Module Outline last reviewed: January 2016 Date Module Outline last modified January 2016

2 A. Objectives AIMS FELLOWSHIP CURRICULUM TS I This Module is designed to provide the candidate with a sound working knowledge of Transfusion Science as it pertains to the transfusion support of patients, and the investigation of immunohaematological states. The Module assumes a basic knowledge of immunohaematological techniques and principles. B. Interrelationship of the Module to Other Modules This Module provides the immunohaematological basis and management principles relating to the clinical use of blood products and a foundation for extending knowledge of the resolution of difficult immunohaematological problems. ModuleTS 2 Module TS3 Production, Clinical Use and Management of Blood and Blood Products. Reference Laboratory Immunohaematology C. Brief Description This Module will provide a sound working knowledge of the immunohaematological and management basis for the operations of a hospital transfusion laboratory. D. Content 1. Immune Response Mechanisms. 1.1 The functions of T cells & interaction between T cells, antigen presenting cells and B cells. 1.2 Role of associated chemokines & immune response genes. 1.3 Self recognition/tolerance and mechanisms of autoimmunity. 1.4 Factors influencing interaction between antigens, antibodies & complement. 1.5 The immunomodulatory effects of transfusion. Objective: To understand broadly the immune response mechanisms and impact of transfusion 2. Biochemical, Molecular and Genetic aspects and Nomenclature of blood group systems 2.1 Structural and functional features of the antigens of the major blood group systems. 2.2 The key biochemical features of the ABO, P, Le, Ii and MNSs blood group systems 2.3 The genetic basis for the major antigens of the identified red cell blood group systems, including their gene frequencies. 2.4 Molecular structure forming the basis for DNA based methods used for determining the commonly used phenotypes of the ABO, Rh, Kell, Fy, Jk, MNS systems

3 Objective: To establish a sound working knowledge of the established blood group systems, 3 Transfusion Laboratory Techniques 3.1 The principles and technical requirements of current methodology formats for blood grouping, phenotyping, antibody screening, crossmatching, including electronic. 3.2 The quality control and quality assurance requirements for the above serology testing. 3.3 The physicochemical properties of non serological reagents used in transfusion serology. 3.4 The principles, and technical requirements of methodologies and procedures for complex antibody identification, and blood grouping/typing problems. 3.5 Available automated systems for processing pretransfusion testing. Objective: To gain a comprehensive understanding of the technical and quality requirements for the performance of the full range of transfusion and blood group serological testing. 4 Blood Group Antibodies 4.1 The typical serological properties and assessment of the likely clinical significance of the antibodies directed at the major antigens of the known blood group systems. 4.2 The cellular assays used for assessing clinical significance of blood group antibodies. Objective: To be thoroughly familiar with the parameters that characterise blood group antibodies and their clinical significance in various clinical settings. 5 Investigation of Clinical States Transfusion Reactions 5.1 The serological, haematological and biochemical procedures which may be used to investigate suspected haemolytic transfusion reactions. 5.2 The causes of febrile non haemolytic transfusion reactions, relevant investigations that can be conducted and strategies to minimise recurrence. 5.3 The current concepts of the clinical and immunological basis for the occurrence of TRALI. Be able to briefly outline test procedures which can be applied to the investigation of this phenomenon. 5.4 The transfusion implications of IgA deficiency. test methods currently used for the quantitation of IgA and the detection of IgA antibodies.

4 5 (cont d) Investigation of Clinical States (cont d) Haemolytic Disease of the Newborn 5.5 The immunological basis for HDN & the factors that may influence the severity of the disease. 5.6 The antibody specificities most commonly responsible. Cellular assays and serological parameters that may be used to assess the clinical significance of implicated antibodies. 5.7 Techniques for antenatal determination of the blood group antigen status of the foetus. 5.8 Appropriate antenatal testing protocols for patients with and without known clinically significant antibodies. 5.9 Be familiar with current protocols for the administration of anti-d gammaglobulin, and test procedures for determining foetal cell numbers in maternal blood. Autoimmune Haemolytic Anaemias 5.10 The pathogenesis of autoimmune haemolytic anaemias & known triggers initiating these conditions The serological presentations of AHA, & techniques and procedures used for serological investigation, and for providing blood for transfusion. Drug induced haemolytic anaemia 5.12 Be familiar with the drugs most commonly implicated in drug induced haemolytic anaemia The mechanisms by which the different drugs induce haemolysis Techniques used to demonstrate the implication of drugs. Bone marrow / stem cell transplantation 5.15 The serological anomalies resulting from transplantation Selection of appropriate blood group for blood products transfused to patients transplanted from donors of different ABO group. Objective: To ensure a thorough knowledge of the diagnostic and investigative procedures and techniques surrounding immunohaematological and transfusion related disorders 6 Computing systems 6.1 The functional requirements for a comprehensive hospital based transfusion software programme. 6.2 Validation requirements for software.

5 Objective: To be able to evaluate and validate the function and integrity of transfusion software. 7 Transfusion Laboratory Management 7.1 Be familiar with the NPAAC Requirements for Transfusion Laboratory Practice and ANZSBT Guidelines for Pretransfusion Laboratory Practice. 7.2 Review and audit processes for monitoring blood and blood product usage and transfusion related practises. 7.3 Haemovigilance, and adverse event monitoring procedures. 7.4 Blood and blood product inventory management processes. 7.5 Workload management practises. 7.6 Hospital Transfusion Committee membership and functions. Objective: To gain a sound knowledge of regulatory requirements and transfusion service management principles and practice. E. Rationale for Content A comprehensive understanding of the scientific and management principles surrounding the operations of a hospital transfusion laboratory provides the foundation for the provision of an efficient, high quality transfusion service. F. Examination Under the Fellowship Regulations, a 3-hour written examination will be held at the completion of each Module. Each examination will contain a mixture of short answer questions and essay style questions. In some examinations, clinical and laboratory management case based scenarios will be include in the question mix. Examination for this Module will focus on an overall understanding of the principles and procedures across the major topic themes : Immune Response Mechanisms Biochemical, Molecular and Genetic aspects of blood group system Transfusion Laboratory Techniques Blood Group Antibodies Investigation of Clinical States Computing Systems Transfusion Laboratory Management The examination will consist of: Two essay questions, each with a total value of 35 marks; suggested time allocation, 30 minutes per essay total 60 minutes. Twenty short answer questions, each worth five marks total value 100 marks; suggested time allocation five minutes per question total 100 minutes. Twenty minutes for re-reading and review.

6 There will be an initial reading time of 15 minutes during which no writing will be permitted G. Texts and Supporting Material The following texts and reviews are recommended. In addition current volumes of the recommended journals should be consulted for relevant articles. 1 Issitt PD, Anstee DJ., Applied Blood Group Serology. Montgomery Scientific Publications 4 th Edition Technical Manual American Association of Blood banks current Edition 3 Guidelines for Pretransfusion Laboratory Practice. Australian & New Zealand Society of Blood Transfusion 5 th Edition Requirements for Transfusion Laboratory Practice. NPAAC ( National Pathology Accreditation Advisory Council), Australian Government Department of Health and Ageing, Canberra. 2 nd Edition Male D, Brostoff J, Roth D, Roitt I. Immunology, Elsevier, 8 th Edition, Klein HG, Anstee DJ, Mollison s Blood Transfusion in Clinical Medicine, Blackwell Publishing. 12 th Edition Texts and Supporting Material (cont d) Recommended Journals: Transfusion Vox Sanguinis Transfusion Medicine Transfusion Medicine Reviews Immunohaematology H. Appointment of a Mentor Each candidate is required to nominate a member for the Module at the time of application for entry and into the Fellowship Program. If a candidate is unable to nominate a mentor then the candidate should contact the Module Convenor for assistance. The appointment of a mentor is made by the Examinations Council.

7 I. Module Communications Module Convenor: Dr T Cobain trevor.cobain@health.nsw.gov.au Discipline Committee: Ms Dianne Grey Dr D Roxby Ms D Stern J. Candidate Feedback Immediately following notification of the examination result each candidate will be asked to complete a feedback questionnaire on the Module. However, feedback at anytime during the study of the Module is encouraged through the mentor or directly to the Module Convenor.

AIMS FELLOWSHIP CURRICULUM HAEMATOLOGY III

AIMS FELLOWSHIP CURRICULUM HAEMATOLOGY III AIMS FELLOWSHIP CURRICULUM HAEMATOLOGY III Module Title: Module Code: Module Convenor: Discipline Committee: Advanced Cellular Haematology HAEM III Haematology Department St Vincent's Hospital Darlinghurst

More information

Page 1. Principles of Human Immunology. Discipline Committee: Professor Allan Cripps Dr Karla Lemmert Emeritus Professor Jennifer Rolland

Page 1. Principles of Human Immunology. Discipline Committee: Professor Allan Cripps Dr Karla Lemmert Emeritus Professor Jennifer Rolland Module Code: Module Title: Module Convenor: Discipline Committee: IMM I Principles of Human Immunology Dr Karla Lemmert Emeritus Professor Jennifer Rolland Date Module Outline reviewed: November 14, 2006

More information

FAIMS Advanced Haemostasis Module

FAIMS Advanced Haemostasis Module Module Title: Module Code: Module Convenor: Advanced Haemostasis HAEM IV Mr Robert Short Haematology Department St Vincent's Hospital Darlinghurst NSW 2010 Email: rshort@stvincents.com.au Discipline Committee:

More information

Autoimmunity and Principles of Transplantation Immunology

Autoimmunity and Principles of Transplantation Immunology Module Code: Module Title: IMM III Autoimmunity and Principles of Transplantation Immunology Module Convenors: Emeritus Professor Jennifer Rolland and Dr Karla Lemmert Discipline: Professor Allan Cripps

More information

Duration: 12 months May to April

Duration: 12 months May to April SPECIALIST CERTIFICATE IN TRANSFUSION SCIENCE PRACTICE PROGRAMME OF STUDY OVERVIEW Example only Duration: 12 months May to April This document serves as a general programme overview only. To ensure you

More information

Antibody identification. Antibody specificity

Antibody identification. Antibody specificity Red blood cell (RBC) transfusions are frequently used in sickle-cell anaemia (SCA) patients to treat and prevent the complications of their disease. Acute simple transfusions are usually used to treat

More information

Module Convenors: Professor Allan Cripps and Emeritus Professor Jennifer Rolland

Module Convenors: Professor Allan Cripps and Emeritus Professor Jennifer Rolland Module Code: Module Title: IMM IV Infectious Disease and Tumor Immunology Module Convenors: Professor Allan Cripps and Emeritus Professor Jennifer Rolland Discipline Committee: Professor Allan Cripps Dr

More information

Provision of Red Cell Transfusion Support for Transfusion Dependent Patients

Provision of Red Cell Transfusion Support for Transfusion Dependent Patients 1.0 Definition Transfusion dependent patients are those who require frequent and long-term transfusion support to sustain life. Most such patients have been diagnosed with one of the following conditions:

More information

SICKLE CELL AWARENESS. The Sickle Cell Society has produced the following information leaflets available at sicklecellsociety.org

SICKLE CELL AWARENESS. The Sickle Cell Society has produced the following information leaflets available at sicklecellsociety.org sickle cell disease in the UK Sickle cell disease (SCD) affects around 15,000 people in the UK People with Sickle Cell Disease have Sickle haemoglobin (HbS) which can make red blood cells rigid and sickle-shaped

More information

CURRENT COURSE OFFERINGS

CURRENT COURSE OFFERINGS The American Red Cross offers regular educational opportunities as a convenient way for healthcare providers to receive relevant blood banking and transfusion medicine information. The bi-monthly sessions,

More information

Essentials of Blood Group Antigens and Antibodies

Essentials of Blood Group Antigens and Antibodies Essentials of Blood Group Antigens and Antibodies Non-Medical Authorisation of blood Components Nov 2017 East Midlands Regional Transfusion Committee Transfusion Terminology Antigens and Antibodies Antibodies

More information

Other Blood group systems

Other Blood group systems Other Blood group systems Blood group systems Dean, L (2005) Blood Group systems Blood group systems can be divided into: 1- Carbohydrate based systems such as Lewis, P and Ii (ABO system also belong to

More information

AIHA The Laboratory Perspective on Testing. Tom Bullock Joint UK NEQAS (BTLP) & BBTS BBT SIG Annual Meeting 20 th November 2018

AIHA The Laboratory Perspective on Testing. Tom Bullock Joint UK NEQAS (BTLP) & BBTS BBT SIG Annual Meeting 20 th November 2018 AIHA The Laboratory Perspective on Testing Tom Bullock Joint UK NEQAS (BTLP) & BBTS BBT SIG Annual Meeting 20 th November 2018 Auto Immune Haemolytic Anaemia (AIHA) BSH guideline (Hill et al. 2017): AIHA

More information

ALL Blood Transfusion samples must be hand-written in accordance with the Trust's Blood Administration Protocol

ALL Blood Transfusion samples must be hand-written in accordance with the Trust's Blood Administration Protocol Blood Transfusion Routine Investigations ALL Blood Transfusion samples must be hand-written in accordance with the Trust's Blood Administration Protocol Full Group & Screen 2ml EDTA Can be stored at 2-8C

More information

Immunohematology Case Studies

Immunohematology Case Studies Immunohematology Case Studies 2016-2 Nicole Thornton International Blood Group Reference Laboratory (IBGRL) NHS Blood and Transplant Bristol, United Kingdom nicole.thornton@nhsbt.nhs.uk Clinical History

More information

Dr Rock LEUNG Transfusion Safety Officer Queen Mary Hospital, Hong Kong West Cluster

Dr Rock LEUNG Transfusion Safety Officer Queen Mary Hospital, Hong Kong West Cluster Dr Rock LEUNG Transfusion Safety Officer Queen Mary Hospital, Hong Kong West Cluster HOSPITAL TRANSFUSION SERVICE IN HK Single supplier for the territory: HK Red Cross Blood Transfusion Service Public

More information

BLOOD TRANSFUSION. Dr Lumka Ntabeni

BLOOD TRANSFUSION. Dr Lumka Ntabeni BLOOD TRANSFUSION Dr Lumka Ntabeni Blood transfusion definition SAFE transfer of BLOOD COMPONENTS from a DONOR to a RECEPIENT CONTENT Brief history of blood transfusion How is safety guaranteed? How do

More information

Transfusion Awareness

Transfusion Awareness Transfusion Awareness Learning Outcomes By the end of this you should be able to: Explain sample validity and the importance of the group check sample (2 sample rule) Discuss the significance of the ABO

More information

Transfusion in Sickle Cell Disease What the guidelines [are likely to] say. Dr Bernard Davis Whittington Hospital, London

Transfusion in Sickle Cell Disease What the guidelines [are likely to] say. Dr Bernard Davis Whittington Hospital, London Transfusion in Sickle Cell Disease What the guidelines [are likely to] say Dr Bernard Davis Whittington Hospital, London Background to BCSH Guideline Rationale Current guidance in disparate publications

More information

Immunohematology (Introduction) References: -Blood Groups and Red Cell Antigens (Laura Dean) -Cellular and molecular immunology, 8 th edition

Immunohematology (Introduction) References: -Blood Groups and Red Cell Antigens (Laura Dean) -Cellular and molecular immunology, 8 th edition Immunohematology (Introduction) References: -Blood Groups and Red Cell Antigens (Laura Dean) -Cellular and molecular immunology, 8 th edition Introduction to replace blood lost by hemorrhage or to correct

More information

Documentation of Changes to EFI Standards: v 5.6.1

Documentation of Changes to EFI Standards: v 5.6.1 Modified Standard B - PERSONNEL QUALIFICATIONS B1.000 The laboratory must employ one or more individuals who meet the qualifications and fulfil the responsibilities of the Director/Co-Director, Technical

More information

Immunohematology (Introduction)

Immunohematology (Introduction) Modified from Serotonin version Immunohematology (Introduction) References: -Blood Groups and Red Cell Antigens (Laura Dean) -Cellular and molecular immunology, 8 th edition Introduction to replace blood

More information

Antibody Information

Antibody Information Antibody Information Rh Blood Group System Anti-D is an IgG antibody directed against the D antigen in the Rh blood group system. Anti-D is Newborn. Patients with Anti-D should receive D- blood (Rh negative).

More information

Implementation of the Stem Cell Therapeutic and Research Act of 2005

Implementation of the Stem Cell Therapeutic and Research Act of 2005 Implementation of the Stem Cell Therapeutic and Research Act of 2005 The 6 th Annual Somatic Cell Therapy Symposium Bethesda, MD September 26, 2006 James F. Burdick, M.D. U.S. Department of Health and

More information

Medical Laboratory Accreditation Programme

Medical Laboratory Accreditation Programme Client Client Number 7551 Address Pathlab Lakes Ltd - Rotorua, PO Box 130, Seventh Avenue, Tauranga, 3140 Rotorua Hospital, Pukeroa Street, Rotorua, 3010 Telephone 07 349-7907 URL Authorised Representative

More information

CTYOMEGALOVIRUS (CMV) - BACKGROUND

CTYOMEGALOVIRUS (CMV) - BACKGROUND CTYOMEGALOVIRUS (CMV) - BACKGROUND PURPOSE The flowing information provides guidance on the use of CMV negative blood components provided by the blood bank at the Royal Children s Hospital (RCH) including

More information

All institutions that transfuse blood components and products should implement national and local policies and written procedures for:

All institutions that transfuse blood components and products should implement national and local policies and written procedures for: 5.0 GENERAL GUIDE TO GOOD TRANSFUSION PRACTICE Blood and the various components prepared or manufactured from it are biologic (in the case of blood cells, living human tissues) products intended for use

More information

Significance of Antibodies and appropriate selection of red cells for transfusion Chris Elliott Haematology Service manager

Significance of Antibodies and appropriate selection of red cells for transfusion Chris Elliott Haematology Service manager Significance of Antibodies and appropriate selection of red cells for transfusion Chris Elliott Haematology Service manager James Cook University Hospital Friarage Hospital Over the next 30 minutes Bit

More information

Blood transfusion. Dr. J. Potgieter Dept. of Haematology NHLS - TAD

Blood transfusion. Dr. J. Potgieter Dept. of Haematology NHLS - TAD Blood transfusion Dr. J. Potgieter Dept. of Haematology NHLS - TAD General Blood is collected from volunteer donors >90% is separated into individual components and plasma Donors should be: healthy, have

More information

Database on Blood Safety 2009 in ECO Member States

Database on Blood Safety 2009 in ECO Member States Database on Blood Safety 2009 in ECO Member States Section 1: Administrative Information Information provided by: 1.1 Name: 1.2 Title: 1.3 Position: 1.4 Organization: 1.5 Address: 1.6 Country: 1.7 Tel.

More information

Guide to the preparation, use and quality assurance of blood components

Guide to the preparation, use and quality assurance of blood components Contents Foreword...3 Members of the European Committee (Partial Agreement) on Blood Transfusion... 8 Members of the GTS working group... 22 Members of the TS066 working group... 30 Recommendation No.

More information

Blood Component Testing and Labeling

Blood Component Testing and Labeling Blood Component Testing and Labeling Each donor unite must be tested and properly labeled before its release for transfusion. Required Tests: In most blood banks, pretransfusion testing involves determining

More information

Measuring IgG anti-a/b titres using dithiothreitol (DTT)

Measuring IgG anti-a/b titres using dithiothreitol (DTT) Measuring IgG anti-a/b titres using dithiothreitol (DTT) R. C. KNIGHT From the Department of Haematology, St Thomas's Hospital, London SEJ Journal of Clinical Pathology, 1978, 31, 283-287 SUMMARY In comparing

More information

Title: Blood Transfusion Laboratory User Handbook

Title: Blood Transfusion Laboratory User Handbook Title: Blood Transfusion Laboratory User Handbook No.of copies : 1 Location of copies : 1. Web site 2. Contents Introduction 2 High risk specimens 2 Referred work 2 Location of the laboratory 2 Transportation

More information

Red Cell Immunohaematology

Red Cell Immunohaematology Red Cell Immunohaematology USER GUIDE 2008 User Guide Author(s): Vanessa Winfield Page 1 of 23 Contents This guide NHS Blood and Transplant Management of Red Cell Immunohaematology Quality statement Complaints

More information

RHESUS BLOOD GROUP SYSTEM (Author: Alvine Janse van Rensburg; ND Biomedical Technology-Microbiology, Haematology, Chemistry)

RHESUS BLOOD GROUP SYSTEM (Author: Alvine Janse van Rensburg; ND Biomedical Technology-Microbiology, Haematology, Chemistry) RHESUS BLOOD GROUP SYSTEM (Author: Alvine Janse van Rensburg; ND Biomedical Technology-Microbiology, Haematology, Chemistry) Introduction The term Rh refers to a complex blood group system that comprised

More information

Passenger Lymphocyte Syndrome (case presentation) Dr. Namal Bandara Kings College Hospital

Passenger Lymphocyte Syndrome (case presentation) Dr. Namal Bandara Kings College Hospital Passenger Lymphocyte Syndrome (case presentation) Dr. Namal Bandara Kings College Hospital Case history 24year Female Known Patient with Wilsons Disease DBD donor Liver Transplantation done on 15/08/2016

More information

Co-dominance. Dr.Shivani Gupta, Department of Zoology, PGGCG-11, Chandigarh

Co-dominance. Dr.Shivani Gupta, Department of Zoology, PGGCG-11, Chandigarh Co-dominance Dr.Shivani Gupta, Department of Zoology, PGGCG-11, Chandigarh Blood groups and Rhesus factor History of Blood Groups and Blood Transfusions Experiments with blood transfusions have been carried

More information

Blood transfusion as a management strategy for Haemoglobinopathy. Corrina McMahon Our Lady s Children s Hospital, Dublin, Ireland

Blood transfusion as a management strategy for Haemoglobinopathy. Corrina McMahon Our Lady s Children s Hospital, Dublin, Ireland Blood transfusion as a management strategy for Haemoglobinopathy Corrina McMahon Our Lady s Children s Hospital, Dublin, Ireland Rationale for BT Sickle cell Disease Reduce the production of Hb Significant

More information

Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK

Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Department of Haematology and Blood Transfusion 3 rd Floor Pathology Directorate Darent Valley Hospital Darenth Wood Road Dartford Kent DA2

More information

POSTGRADUATE INSTITUTE OF MEDICINE UNIVERSITY OF COLOMBO POSTGRADUATE DIPLOMA IN CLINICAL HAEMATOLOGY EXAMINATION - JUNE 2014 PAPER I - ESSAY

POSTGRADUATE INSTITUTE OF MEDICINE UNIVERSITY OF COLOMBO POSTGRADUATE DIPLOMA IN CLINICAL HAEMATOLOGY EXAMINATION - JUNE 2014 PAPER I - ESSAY POSTGRADUATE INSTITUTE OF MEDICINE UNIVERSITY OF COLOMBO POSTGRADUATE DIPLOMA IN CLINICAL HAEMATOLOGY EXAMINATION - JUNE 2014 Date :- 23 rd June 2014 Time 1.00 p.m. - 4.00 p.m. Answer four questions only.

More information

It s not just allo-antibodies that a red cell transfusion can stimulate

It s not just allo-antibodies that a red cell transfusion can stimulate It s not just allo-antibodies that a red cell transfusion can stimulate Associate Professor Ralph Green Laboratory Medicine RMIT University Melbourne, Australia Transfusion practice Minimise risk of transmitting

More information

Kidd Blood Group System

Kidd Blood Group System Kidd Blood Group System Qun Lu, MD Assistant Professor Division of Transfusion Medicine Department of Pathology and Laboratory Medicine UCLA, School of Medicine Los Angeles, California 02-05-2009 History

More information

Transfusion Guidelines in AIHA; Indications, Compatibility Testing and Administration.

Transfusion Guidelines in AIHA; Indications, Compatibility Testing and Administration. Transfusion Guidelines in AIHA; Indications, Compatibility Testing and Administration. Lawrence D. Petz, M.D. Emeritus Professor University of California Los Angeles, California, U.S.A.; Medical Director

More information

Guidelines for the Management of Urgent Red Cell Transfusion and Situations when Serological Compatibility cannot be Assured

Guidelines for the Management of Urgent Red Cell Transfusion and Situations when Serological Compatibility cannot be Assured 1. Aim This document aims to provide guidance on the selection of the most appropriate red cells when the urgency of the need for transfusion dictates that serologically compatible blood will not be available.

More information

CURRICULUM OUTLINING COMPETENCIES REQUIRED FOR INTERNS TO ATTAIN HPCSA REGISTRATION AS MEDICAL SCIENTISTS CATEGORY

CURRICULUM OUTLINING COMPETENCIES REQUIRED FOR INTERNS TO ATTAIN HPCSA REGISTRATION AS MEDICAL SCIENTISTS CATEGORY CURRICULUM OUTLINING COMPETENCIES REQUIRED FOR INTERNS TO ATTAIN HPCSA REGISTRATION AS MEDICAL SCIENTISTS CATEGORY Medical Biological Science DISCIPLINE Genetics This document serves to provide a framework

More information

IMMUNOHEMATOLOGY. Bio-Rad Laboratories. 2014/2015 Catalog. The Complete Solution for Safe Transfusion. ID-System

IMMUNOHEMATOLOGY. Bio-Rad Laboratories. 2014/2015 Catalog. The Complete Solution for Safe Transfusion. ID-System Bio-Rad Laboratories IMMUNOHEMATOLOGY ID-System 2014/2015 Catalog The Complete Solution for Safe Transfusion ID-System 2014/2015 Catalog The Complete Solution for Safe Transfusion Bibliography [1] Issitt,

More information

EUROPEAN COMMISSION HEALTH AND FOOD SAFETY DIRECTORATE-GENERAL

EUROPEAN COMMISSION HEALTH AND FOOD SAFETY DIRECTORATE-GENERAL Ref. Ares(2015)2319265-03/06/2015 EUROPEAN COMMISSION HEALTH AND FOOD SAFETY DIRECTORATE-GENERAL Directorate D - Health systems and products D4 Substances of Human Origin and Tobacco Control Brussels,

More information

HEADACHES AFTER Bone Marrow Transplant

HEADACHES AFTER Bone Marrow Transplant HEADACHES AFTER Bone Marrow Transplant This is the first slide Peter Russell, Supervising Scientist, Transfusion Haematology, Queensland Pathology Central RBWH, Herston Rd, HERSTON, QLD. 4029, Australia.

More information

Principles of In Vitro Diagnostic (IVD) Medical Devices Classification

Principles of In Vitro Diagnostic (IVD) Medical Devices Classification Technical Reference: TR-006 Date of Issue: 1 Dec. 2009 Principles of In Vitro Diagnostic (IVD) Medical Devices Classification Technical Reference: TR-006 Department of Health The G overnment of the Hong

More information

BCSH Appropriate Use of O Neg. Dr Megan Rowley Consultant In Transfusion Medicine SNBTS at the Royal Infirmary of Edinburgh

BCSH Appropriate Use of O Neg. Dr Megan Rowley Consultant In Transfusion Medicine SNBTS at the Royal Infirmary of Edinburgh BCSH Appropriate Use of O Neg Dr Megan Rowley Consultant In Transfusion Medicine SNBTS at the Royal Infirmary of Edinburgh http://www.b-sh.org.uk/guidelines/ Good Practice Paper Used to recommend good

More information

All you wanted to know about transfusion support for transplants

All you wanted to know about transfusion support for transplants All you wanted to know about transfusion support for transplants Dr Dora Foukaneli NHSBT and Addenbrooke s Hospital Cambridge When / why / why not? What ABO group? Do other groups matter? Transplantation

More information

Blood Banking in India: Ten Years Later

Blood Banking in India: Ten Years Later Blood Banking in India: Ten Years Later Sue Johnson, MSTM, MT(ASCP)SBB Director, Clinical Education BloodCenter of Wisconsin Milwaukee, WI Objectives Describe the Indian Immunohematology Initiative. Explain

More information

Blood Banking in India: Ten Years Later. Sue Johnson, MSTM, MT(ASCP)SBB Director, Clinical Education BloodCenter of Wisconsin Milwaukee, WI

Blood Banking in India: Ten Years Later. Sue Johnson, MSTM, MT(ASCP)SBB Director, Clinical Education BloodCenter of Wisconsin Milwaukee, WI Blood Banking in India: Ten Years Later Sue Johnson, MSTM, MT(ASCP)SBB Director, Clinical Education BloodCenter of Wisconsin Milwaukee, WI Objectives Describe the Indian Immunohematology Initiative. Explain

More information

Immunohematology. Done by : Zaid Al-Ghnaneem

Immunohematology. Done by : Zaid Al-Ghnaneem Immunohematology Done by : Zaid Al-Ghnaneem Hello everyone, in this sheet we will talk mainly about immunohematology which is the reactions between our immune system with Antigens found mainly within blood

More information

Transfusion Reactions. Directed by M-azad March 2012

Transfusion Reactions. Directed by M-azad March 2012 Transfusion Reactions Directed by M-azad March 2012 Transfusion Reactions are Adverse reactions associated with the transfusion of blood and its components Transfusion reactions Non-threatening to fatal

More information

EUROPEAN COMMISSION DIRECTORATE GENERAL FOR HEALTH AND FOOD SAFETY

EUROPEAN COMMISSION DIRECTORATE GENERAL FOR HEALTH AND FOOD SAFETY Ref. Ares(2016)5909621-13/10/2016 EUROPEAN COMMISSION DIRECTORATE GENERAL FOR HEALTH AND FOOD SAFETY Directorate B - Health systems, medical products and innovation B4 Medical products: quality, safety

More information

Dr.Rajeshwari Basavanna, Dr.Biju George, Dr.Dolly Daniel Transfusion Medicine and Immunohaematology Department of Haematology CMC Vellore

Dr.Rajeshwari Basavanna, Dr.Biju George, Dr.Dolly Daniel Transfusion Medicine and Immunohaematology Department of Haematology CMC Vellore Dr.Rajeshwari Basavanna, Dr.Biju George, Dr.Dolly Daniel Transfusion Medicine and Immunohaematology Department of Haematology CMC Vellore Background Clinical Severity of disease Autoimmune Haemolytic anaemia

More information

W A Flegel Florianopolis 11 Nov General aspects and advances in RH and other blood groups. RHCE: ancestral position RHD is the duplicated gene

W A Flegel Florianopolis 11 Nov General aspects and advances in RH and other blood groups. RHCE: ancestral position RHD is the duplicated gene General aspects and advances in RH and other blood groups Florianopolis 17h15-17h45 W. A. Flegel, MD Professor Transfusion Medicine Chief, Laboratory Services Section, Dept. Transfusion Medicine, Center

More information

Transfusion Medicine (Comprehensive, Limited) J, J1

Transfusion Medicine (Comprehensive, Limited) J, J1 www.cap.org Transfusion Medicine Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS). Transfusion Medicine (Comprehensive, Limited)

More information

Significance of Antibodies and appropriate selection of red cells for transfusion. Divis ion of Pat hology

Significance of Antibodies and appropriate selection of red cells for transfusion. Divis ion of Pat hology Significance of Antibodies and appropriate selection of red cells for transfusion Bit of basic immunology Serological red cell transfusion reactions Testing and sample timing Problems Coping strategies

More information

IMMUNOLOGICAL REACTIONS TO BLOOD AND BLOOD PRODUCTS

IMMUNOLOGICAL REACTIONS TO BLOOD AND BLOOD PRODUCTS Br.J. Anaesth. (1979), 51, 45 IMMUNOLOGICAL REACTIONS TO BLOOD AND BLOOD PRODUCTS P. HlLGARD It is estimated that approximately one-third of all blood transfusions are given during anaesthesia (Van Dijk

More information

Candidates must answer ALL questions

Candidates must answer ALL questions Time allowed: Three hours. Part 1 examination Haematology: First paper Tuesday 22 March 2016 Candidates must answer ALL questions Question 1: General Haematology A 16 year old non-european is referred

More information

Warm Reactive Autoantibodies Clinical and Serologic Correlations

Warm Reactive Autoantibodies Clinical and Serologic Correlations Coagulation and Transfusion Medicine / CHARACTERISTICS OF WARM AUTOANTIBODIES Warm Reactive Autoantibodies Clinical and Serologic Correlations Christine A. Wheeler, MD, * Loni Calhoun, MT(ASCP)SBB, and

More information

Supporting solid organ transplants: Challenges for Blood Transfusion Labs

Supporting solid organ transplants: Challenges for Blood Transfusion Labs Supporting solid organ transplants: Challenges for Blood Transfusion Labs Dora Foukaneli Consultant in Haematology and Transfusion Medicine NHSBT Cambridge and Addenbrooke s Hospital Addenbrooke s Blood

More information

Blood Transfusions in Children with Haemoglobinopathies

Blood Transfusions in Children with Haemoglobinopathies Blood Transfusions in Children with Haemoglobinopathies Version: 2 Date: 22 nd April 2010 Authors: Responsible committee or Director: Review date: Target audience: Stakeholders/ committees involved in

More information

NLBCP-017 INDIRECT ANTIGLOBULIN CROSSMATCH TUBE METHOD. Issuing Authority

NLBCP-017 INDIRECT ANTIGLOBULIN CROSSMATCH TUBE METHOD. Issuing Authority Government of Newfoundland and Labrador Department of Health and Community Services Provincial Blood Coordinating Program INDIRECT ANTIGLOBULIN CROSSMATCH TUBE METHOD Office of Administrative Responsibility

More information

Significance of Antibodies and appropriate selection of red cells for transfusion

Significance of Antibodies and appropriate selection of red cells for transfusion Significance of Antibodies and appropriate selection of red cells for transfusion James Cook University Hospital Friarage Hospital Bit of basic immunology Serological red cell transfusion reactions Testing

More information

DIAGNOSTIC SERVICES MANITOBA

DIAGNOSTIC SERVICES MANITOBA DIAGNOSTIC SERVICES MANITOBA YEAR IN REVIEW JANUARY DECEMBER 2012 CANADIAN BLOOD SERVICES MANITOBA DIAGNOSTIC SERVICES SENIOR STAFF AND CONTACT INFORMATION MEDICAL DIRECTOR Debra Lane MD, FRCPC 204.789.1079

More information

2. Blood group antigens are surface markers on the red blood cell membrane

2. Blood group antigens are surface markers on the red blood cell membrane 2. Blood group antigens are surface markers on the red blood cell membrane Before the 1900s, it was thought that all blood was the same, a misunderstanding that led to frequently fatal transfusions of

More information

The establishment of well-organized, nationally-coordinated blood transfusion services with quality systems in all areas

The establishment of well-organized, nationally-coordinated blood transfusion services with quality systems in all areas Blood Safety Global Database on Blood Safety (GDBS) 2013 The World Health Organization (WHO) programme on Blood Transfusion Safety would appreciate your kind cooperation in completing this data collection

More information

APPENDIX 2. Appendix 2 MoU

APPENDIX 2. Appendix 2 MoU APPENDIX 2 THIS APPENDIX CONTAINS BOTH THE TEXT OF THE CURRENT MEMORANDUM OF UNDERSTANDING BETWEEN JCSTD, THE GDC AND COPDEND ABOUT THEIR JOINT WORKING ARRANGEMENTS AND THE WORKING NOTES DRAFTED BY PROF

More information

Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK

Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Haematology & Blood Transfusion Contact: Neil Wrathall The Christie Tel: +44 (0) 161 918 7264 Wilmslow Road Fax: +44 (0) 161 446 8549 Manchester

More information

Quality Assurance in Immunohaematology for Bhutan, India and Maldives

Quality Assurance in Immunohaematology for Bhutan, India and Maldives SEA-HLM-367 Distribution: General Quality Assurance in Immunohaematology for Bhutan, India and Maldives Report of a Sub-regional Training Course Mumbai, India, 23-27 September 2002 WHO Project No: ICP

More information

Qualifications that are substantially equivalent demonstrate evidence for each of the five requirements:

Qualifications that are substantially equivalent demonstrate evidence for each of the five requirements: The Australian Physiotherapy Council provides advice to the Physiotherapy Board of Australia regarding qualifications that are substantially equivalent to an approved Australian physiotherapy qualification.

More information

Human Blood Groups. ABO Blood Grouping 5/1/12. Dr Badri Paudel Landsteiner s Rule

Human Blood Groups. ABO Blood Grouping 5/1/12. Dr Badri Paudel  Landsteiner s Rule Human Blood Groups ABO Blood Grouping Dr Badri Paudel www.badripaudel.com RBC membranes have glycoprotein an:gens on their external surfaces These an:gens are: Unique to the individual Recognized as foreign

More information

APPENDIX -1 LIST OF TABLES. 01 The blood group systems Blood group collections

APPENDIX -1 LIST OF TABLES. 01 The blood group systems Blood group collections APPENDIX -1 LIST OF TABLES Table 01 The blood group systems. 014 005 02 Blood group collections. 016 008 03 Low frequency antigens: the 700 series. 017 009 04 Frequencies of low frequency antigens. 017

More information

Direct Antiglobulin Test (DAT)

Direct Antiglobulin Test (DAT) Exercise 8 Direct Antiglobulin Test (DAT) Objectives 1. State the purpose for performing the DAT. 2. State what a positive DAT indicates. 3. List the reagents which are used for performing the DAT. 4.

More information

Dr Rosline Hassan Haematology Department, School of Medical Sciences, Universiti Sains Malaysia, Kelantan

Dr Rosline Hassan Haematology Department, School of Medical Sciences, Universiti Sains Malaysia, Kelantan Dr Rosline Hassan Haematology Department, School of Medical Sciences, Universiti Sains Malaysia, Kelantan THE FIRST ASEAN FEDERATION OF HAEMATOLOGY AND THE VIIITH MALAYSIAN NATIONAL HAEMATOLOGY SCIENTIFIC

More information

DIAGNOSTIC SERVICES MANITOBA YEAR IN REVIEW JANUARY DECEMBER 2017

DIAGNOSTIC SERVICES MANITOBA YEAR IN REVIEW JANUARY DECEMBER 2017 DIAGNOSTIC SERVICES MANITOBA YEAR IN REVIEW JANUARY DECEMBER 2017 Diagnostic Services Year in Review statistics are based on a January to December calendar year. The calendar year provides better correlation

More information

Specific Requirements

Specific Requirements Specific Requirements AIMS Specific requirements your patients have for transfusion and how this is managed Classify which patients require: Irradiated components CMV negative components Washed components

More information

Fifty ways to fail your patient. Haemolytic transfusion reactions

Fifty ways to fail your patient. Haemolytic transfusion reactions Fifty ways to fail your patient Haemolytic transfusion reactions Nearly Fifty ways to fail your patient Haemolytic transfusion reactions Acute haemolytic transfusion reaction (AHTR): definition Fever and

More information

Transfusion Errors in Transplant Recipients. Paula Bolton-Maggs Alison Watt Debbi Poles Serious Hazards of Transfusion

Transfusion Errors in Transplant Recipients. Paula Bolton-Maggs Alison Watt Debbi Poles Serious Hazards of Transfusion Transfusion Errors in Transplant Recipients Paula Bolton-Maggs Alison Watt Debbi Poles Serious Hazards of Transfusion BBTS September 2016 Transfusion risks in transplantation Patients receiving transplants,

More information

Careers in Haematology

Careers in Haematology Careers in Haematology A guide for medical students and junior doctors About haematology: Haematology is the medical speciality concerned with blood disorders. Your non-medical friends however will always

More information

European actions in the field of transplantation & blood transfusion

European actions in the field of transplantation & blood transfusion European actions in the field of transplantation & blood transfusion Andrzej Rys Director Directorate Health Systems and Products Madrid, 27 June 2013 1 Blood Tissues and cells Organs 2 Blood transfusion

More information

CHAPTER 10 BLOOD GROUPS: ABO AND Rh

CHAPTER 10 BLOOD GROUPS: ABO AND Rh CHAPTER 10 BLOOD GROUPS: ABO AND Rh The success of human blood transfusions requires compatibility for the two major blood group antigen systems, namely ABO and Rh. The ABO system is defined by two red

More information

Guidelines for Requesting Type and Screen Testing for Elective Surgical Adult Patients within the WRHA Surgery Program

Guidelines for Requesting Type and Screen Testing for Elective Surgical Adult Patients within the WRHA Surgery Program Guidelines for Requesting Type and Screen Testing for Elective Surgical Adult Patients within the WRHA Surgery Program BACKGROUND Request for preoperative blood testing, specifically Type and Screen (T&S)

More information

Title: SECTION 7.0 NZBMDR STANDARDS PROCESS FOR DONOR IDENTIFICATION

Title: SECTION 7.0 NZBMDR STANDARDS PROCESS FOR DONOR IDENTIFICATION Title: SECTION 7.0 NZBMDR STANDARDS PROCESS FOR DONOR IDENTIFICATION Authorised by: Executive Officer Contributing Authors: ABMDR Scientific Expert Advisory Committee Sally Gordon Dr Hilary Blacklock Raewyn

More information

UK NEQAS Low Level Leucocyte Enumeration Programme. Mr Matthew Fletcher Advanced Biomedical Scientist UK NEQAS for Leucocyte Immunophenotyping

UK NEQAS Low Level Leucocyte Enumeration Programme. Mr Matthew Fletcher Advanced Biomedical Scientist UK NEQAS for Leucocyte Immunophenotyping UK NEQAS Low Level Leucocyte Enumeration Programme Mr Matthew Fletcher Advanced Biomedical Scientist UK NEQAS for Leucocyte Immunophenotyping Content Results of the UKNEQASLI flow cytometry survey Analysis

More information

Meeting the Challenging Transfusion Needs of a Diverse Patient Population

Meeting the Challenging Transfusion Needs of a Diverse Patient Population Presented by: Christy P. Beal Manager, Immunohematology Reference Laboratory American Red Cross Blood Services Southern Region, Douglasville, GA Southeastern Area Blood Bankers Meeting March 24, 2017 Objectives

More information

Maintaining a Safe and Adequate Blood Supply in the Event of Pandemic Influenza. Guidelines for National Blood Transfusion Services

Maintaining a Safe and Adequate Blood Supply in the Event of Pandemic Influenza. Guidelines for National Blood Transfusion Services Maintaining a Safe and Adequate Blood Supply in the Event of Pandemic Influenza Guidelines for National Blood Transfusion Services 19 May 2006 1 Rationale Current global concern that an occurrence of pandemic

More information

25/10/2017. Clinical Relevance of the HLA System in Blood Transfusion. Outline of talk. Major Histocompatibility Complex

25/10/2017. Clinical Relevance of the HLA System in Blood Transfusion. Outline of talk. Major Histocompatibility Complex Clinical Relevance of the HLA System in Blood Transfusion Dr Colin J Brown PhD FRCPath. October 2017 Outline of talk HLA genes, structure and function HLA and immune complications of transfusion TA-GVHD

More information

Non-Medical Authorisation Course

Non-Medical Authorisation Course Non-Medical Authorisation Course November 2017 Authorising, Prescribing & Sampling Janice Smith Matron Transfusion Specialist Aims of this session To discuss and understand: Authorising blood / blood components

More information

HUNGARIAN NATIONAL BLOOD TRANSFUSION SERVICE. Dr. Klara Baroti-Tóth, PhD IPFA/PEI 19 th International Workshop Budapest, May, 2012.

HUNGARIAN NATIONAL BLOOD TRANSFUSION SERVICE. Dr. Klara Baroti-Tóth, PhD IPFA/PEI 19 th International Workshop Budapest, May, 2012. HUNGARIAN NATIONAL BLOOD TRANSFUSION SERVICE Dr. Klara Baroti-Tóth, PhD IPFA/PEI 19 th International Workshop Budapest, 23-24 May, 212. BLOOD DONATION G I V I N G I S G O O D ORGAN COORDINATION OFFICE

More information

Immunohaematology: a branch of immunology that deals with the immunologic properties of blood.

Immunohaematology: a branch of immunology that deals with the immunologic properties of blood. 1 Immunohaematology: a branch of immunology that deals with the immunologic properties of blood. The red blood cells have on their surface hundreds of antigens and according to the antigen on their surface

More information

PILOT STUDY OF ANTIGEN MATCHING FOR AUTOIMMUNE HEMOLYTIC ANEMIA

PILOT STUDY OF ANTIGEN MATCHING FOR AUTOIMMUNE HEMOLYTIC ANEMIA PILOT STUDY OF ANTIGEN MATCHING FOR AUTOIMMUNE HEMOLYTIC ANEMIA Sharon Rice & Fred Plapp Saint Luke s Hospital Kansas City, MO CENTRALIZED TRANSFUSION SERVICE Antibody identification Antibody titer Antigen

More information

Frequency & specificity of RBC alloantibodies in patients due for surgery in Iran

Frequency & specificity of RBC alloantibodies in patients due for surgery in Iran Indian J Med Res 138, August 2013, pp 252-256 Frequency & specificity of RBC alloantibodies in patients due for surgery in Iran Khademi Reyhaneh 1, Gharehbaghian Ahmad 2, Karimi Gharib 1, Vafaiyan Vida

More information

Information for patients with Sickle Cell Disease who may need a blood transfusion. Patient information

Information for patients with Sickle Cell Disease who may need a blood transfusion. Patient information Information for patients with Sickle Cell Disease who may need a blood transfusion Patient information This information leaflet answers some of the questions you may have about having a blood transfusion

More information

Peer mentoring in higher education: a reciprocal route to student success

Peer mentoring in higher education: a reciprocal route to student success Peer mentoring in higher education: a reciprocal route to student success Robin Clark* and Jane Andrews, Aston University * r.p.clark@aston.ac.uk Engineering Education Research Group School of Engineering

More information