The Gut Microbiome: 101 Justin Carlson University of Minnesota
|
|
- Jack Maxwell
- 6 years ago
- Views:
Transcription
1 The Gut Microbiome: 101 Justin Carlson University of Minnesota Where are we now? 360 B.C Human Gut Microbes Associated With Obesity Ley et al., Nature
2 Consumer Driven Science For Better of For Worse? (Google Analytics, 2016) Microbiome Trends Relative Frequency: Probiotic Searches Relative Frequency: Microbiome Searches (Google Analytics, 2016)
3 Probiotic Market $50 B Market Worldwide Exponential Growth in U.S (1998) 34% T.V. Ads Target Gut Health (Google Analytics, 2016) What are the worst assumptions we can make about gut bacteria? There are good and bad bacteria Probiotics always improve health Probiotics help you lose weight All probiotics are safe
4 Term Definition Probiotics Prebiotics Dietary Fiber live cultures that you eat Example: live bacteria in solution substrate that beneficial bacteria feed on Example: beta-glucans, inulin non-digestible carbohydrates Example: cellulose, hemicellulose Relative Frequency: Microbiome gut microbial Searches genome Gut Microbiome This includes bacteria, metabolites, (Like an organ) substrates, proteins, etc. Gut Microflora bacteria within the distal intestine Example: Bifidobacteria Not all fibers are prebiotics! (Carlson et al., 2016) Fermented Foods vs. Probiotics (Hill et al., Nature Reviews )
5 Bacteria Where Are They? (Appleby, 2008) Taxonomic Classification: 101 Classification Phylum Class Order Family Genus Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Relative Bifidobacterium Frequency: Microbiome Searches Species B. breve, B. bifidum, etc. (Nixon, 2007)
6 Humans: Diverse Hind-Gut Fermenters Relative Frequency: Microbiome Searches (Holmes et al., Cell Metabolism) Intervention Effect on Microbiota Effect on Metabolism Prebiotics Increase Bifidobacteria and Lactobacillus Increase SCFA production Probiotics Balance microbial diversity Increase SCFA production Fiber Carbohydrates Inversely associated with Bacteroides and Actinobacteria and associated with Firmicutes and Proteobaccteria Negatively associated with Bacteroides and positively associated with Prevotella Increase SCFA production Involved in glycolysis Fats Protein Caloric Restriction Positively associated with Bacteroides and Actinobacteria and negatively associated with Firmicutes and Proteobacteria Positively associated with Bacteroides and negatively associated with Prevotella Relative Frequency: Microbiome Searches Higher percentage of proteobacteria in malnutrition Altered Fatty Acids and Triglycerides Increased BCAA Changes in microbiota which are known to be proinflammatory Iron Depletion Increased Lactobacilli and Enterobacteriaceae and decreased Roseburia spp. and E. rectal group Lower cecal butyrate and propionate GI-Surgery Promote growth of Gammaproteobacteria Altered host-microbial cometabolites and amines Choline-Deficient Diet Gammaproteobacteria higher in cholinedeficient diet Homocysteine increased (Holmes et al., Cell Metab.)
7 The Evolution of Symbionts Relative Frequency: Microbiome Searches (Genius, 2009) Are We 10% Human? 100 g of substrate yield 30 g of bacterial biomass Average weight of bacterial biomass production in a lifetime (American Museum of Natural History, Meet Your Microbiome)
8 How is The Gut Microflora Established? (Yatsunenko et al., Nature. 2014) Establishment of the Microflora 10 Things We Know 1. ~80% if the adult microbiome is established by age Breast milk is very rich in Lactobacilli and Bifidobacteria 3. C-section formula-fed babies = less diverse microflora 4. Interactions between the microbiota and host immune system start at birth 5. Share about 10% of the microbial genes with the person next to you % of total diet energy comes from fermentation 7.. Lactobacilli and Bifidobacteria negatively associated with nearly all diseases 8. Changes in the microflora have been correlated with numerous diseases 9. C. dif can be effectively treated with FMT (usually) 10. Average adults carries 3 pounds of bacteria
9 Antibiotics What Do We Blame? Relative Frequency: Microbiome Searches (Blaser et al., Nature Reviews. 2009) (CDC, 2015)
10 Four Daily Choices To Promote Gut Health Ten Most Common Probiotics Worldwide Bifidobacterium Lactobacillus B. adolescentis L. acidophilus B. animalis L. casei B. animalis subsp. animalis L. crispatus B. animalis supsp. lactis L. fermentum B. bifidum L. gasseri B. breve L. johnsonii B. infantis L. plantarum B. lactis L. reuteri B. longum L. rhamnosus B. thermophilum L. salivarius (Carlson et al., 2016)
11 Species Eligible Claims/Purpose Conditions Bifidobacteria adolescentis Bifidobacteria animalis subsp. animalis Bifidobacteria animalis subsp. lactis Bifidobacteria bifidum Bifidobacteria breve Bifidobacteria I nfantis Bifidobacteria longum Lactobacillus acidophilus Lactobacillus casei Lactobacillus fermentum Lactobacillus gasseri Lactobacillus johnsonii Lactobacillus paracasei Lactobacillus plantarum Lactobacillus rhamnosus Lactobacillus salivarius Probiotic that forms/contributes to a natural healthy gut flora Probiotic to benefit health and/or to confer a health benefit Provides live microorganisms that form part of a natural healthy gut flora/that contribute to a natural healthy gut flora/benefit health/confer a health benefit 1.0 x 10^7 to 1.0 x 10^11 CFU of one or more eligible microorganisms/day Lactobacillus Rhamnosus GG Helps to manage acute infectious diarrhea Helps to manage/reduce anti-biotic associated diarrhea 6.0 x 10^9 to 1.2 x 10^10 CFU/day 1.0 x 10^10 to 2.0 x 10^10 CFU/day Lactobacillus johnsonii La1/Lj1/NCC533 Saccharomyces boulardii Saccharomyces cerevisiae An adjunct to physiciansupervised antibiotic therapy in patients with H. pylori infections Helps to reduce the risk of antibiotic-associated diarrhea 1.25 x 10^8 to 3.6 x 10^9 CFU/day 1.0 x 10^10 to 3.0 x 10^10 CFU/day (Carlson et al., 2016) How Do We Analyze The Microflora? (NPR 2014)
12 FMT: Coming To A Clinic Near You Fecal Microbiota Transplants (FMT)
13 The Microbiome: Implications For Diabetes Care Rat Models to Clinical Studies Decreased risk for diabetes onset in populations with very high Lactobacillus concentrations. (Germ-free rats) Mucin-producing bacteria may aid in gut strength. Butyrate production may offer decreased risk for TID. (n=8) MGWAS in China (n=345) found mild dysbiosis in T2D patients and decreased amounts of butyrate-producing bacteria (Brown et., 2011; Qin et al., 2012; Brugman et al., 2006)
14 One Possible Mechanism of Action Lactic Acid Bacteria (Lactobacillus & Bifidobacterium) Lactate Butyrate Producing Bacteria Non-Butyrate Producing Bacteria Butyrate Propionate, Acetate, Etc. Increased mucin synthesis Tighter junctions Decreased Mucin Synthesis Leaky Junctions Increased Gut Integrity Permeable Gut Healthy Individual Autoimmune Individual (Brown et al., ONE. 2011) Current Clinical Studies (Clinicaltrials.gov) Probiotics and Diabetes 17 clinical trials starting or in progress FMT and Diabetes 2 clinical trials enrolling (3/30/16) Prebiotics and Diabetes 4 clinical trials (U.S. and Canada) (Clinicaltrials.gov, 2016)
השפעת חיידקים פרוביוטיים
השפעת חיידקים פרוביוטיים החיים בחלל )המעי(... על רון שאול יחידת גסטרו ילדים מרכז רפואי רמב"ם Introduction The intestinal microflora primarily in the large bowel consists mostly on benign bacterial species
More informationThe role of nutrition in optimum gastrointestinal health
The role of nutrition in optimum gastrointestinal health Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor University Distinguished Teacher-Scholar University of Illinois
More informationThe impact of the microbiome on brain and cognitive development
The Gut-Brain Axis The impact of the microbiome on brain and cognitive development Diane Stadler, PhD, RD Oregon Health & Sciences University, Portland, Oregon Lao-American Nutrition Institute With acknowledgements
More informationHMF Probiotics PROFESSIONAL PRODUCT GUIDE
HMF Probiotics PROFESSIONAL PRODUCT GUIDE NEW Research-driven Proprietary, human-sourced strains Visit wwwseroyalcom/genestrabrands to view the entire GENESTRA BRANDS line Scientifically sound, quality
More informationMore than a gut feeling: How the microbiota improves health
More than a gut feeling: How the microbiota improves health Amanda Ramer-Tait, PhD Harold and Esther Edgerton Assistant Professor of Immunology and Microbiology Department of Food Science, University of
More informationTHE HEALTHY GUT FOR AGING WELL
THE HEALTHY GUT FOR AGING WELL Aging A focus on health and aging always produces the same statement Things just do not work as well when we are older The question is why? If we were a car replace the parts
More informationSlide 1 THE HEALTHY GUT FOR AGING WELL. Slide 2 Aging. Slide 3 Aging
Slide 1 THE HEALTHY GUT FOR AGING WELL Slide 2 Aging A focus on health and aging always produces the same statement Things just do not work as well when we are older The question is why? If we were a car
More informationEED INTERVENTIONS: PRE- AND PRO-BIOTIC SAFETY
EED INTERVENTIONS: PRE- AND PRO-BIOTIC SAFETY Produced by: Dietrich, C.; Kidane, L.; Babigumira, J. Agenda Agenda Timeline Project Background and Objectives Key Takeaways Approach & Rationale Methods Results
More informationEFFECTS OF ALETA IN PROMOTING THE GROWTH OF PROBIOTIC BACTERIA: IN VITRO STUDY
2 Senoko Drive 758 200 Singapore tel: +65.6755.633 www.kemin.com EFFECTS OF ALETA IN PROMOTING THE GROWTH OF PROBIOTIC BACTERIA: IN VITRO STUDY Lakshmibai Vasanthakumari Bindhu. Ph.D Abstract: It is well
More informationHMP is lead by NIH but is an International Consortium.
Human Microbiome The Human Microbiome Project was one of the spin offs of the Human Genome Project. The HMP project started in 2007 with the overall goal of Characterizing the Human Microbiome and determine
More informationPREBIOTIC MECHANISMS OF ACTION
PREBIOTIC MECHANISMS OF ACTION Seema Hooda, Kelly S. Swanson, George C. Fahey, Jr. Department t of Animal Sciences Division of Nutritional Sciences University of Illinois at Urbana-Champaign Institute
More informationThe Intestinal Microbiota and the Developing Immune System
The Intestinal Microbiota and the Developing Immune System 4 Feb 2016 The Intestinal Microbiota 10 fold more bacterial cells than human cells 100-1000 fold more bacterial genes than human genes Why does
More informationThe Gut Factor. Probiotics, the gut microbiome and human health. Thursday November 10, 2016 l 12:00 pm
The Gut Factor Probiotics, the gut microbiome and human health Thursday November 10, 2016 l 12:00 pm Dr. Elena Comelli is an Assistant Professor and holds the Lawson Family Chair in Microbiome Nutrition
More informationEmerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice
Emerging Probiotic Research: A Guide to the Use of Probiotics in Clinical Practice Donald Brown, ND April 13, 2010 Probiotics WHO Definition: Live microorganisms, which when administered in adequate amounts,
More informationOBESITY AND THE CONNECTION TO THE GUT
OBESITY AND THE CONNECTION TO THE GUT Weight Loss Most weight loss programs are based on calorie in = calorie out Does not matter how they are dressed up Most of these plans being healthier foods to people
More informationGUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH?
GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH? Corrie Whisner, PhD School of Nutrition and Health Promotion Arizona State University Center for Research on Ingredient Safety Annual Meeting
More informationThe role of intestinal microbiota in metabolic disease-a novel therapeutic target.
Michael Connolly Department of Food Biosciences, The University of Reading The role of intestinal microbiota in metabolic disease-a novel therapeutic target. University of Reading 2008 www.reading.ac.uk
More information9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives
The Physiological Roles of the Intestinal Microbiota Kelly A. Tappenden, Ph.D., R.D., FASPEN Professor and Head, Kinesiology and Nutrition University Distinguished Teacher-Scholar University of Illinois
More informationThe Gut Microbiota: Evidence For Gut Microbes as Contributors to Weight Gain
The Gut Microbiota: Evidence For Gut Microbes as Contributors to Weight Gain Michael T. Bailey, Ph.D. Center for Microbial Pathogenesis The Research Institute, Nationwide Children s Hospital Department
More informationChoosing the Right Probiotic
Choosing the Right Probiotic Robert Dadd Master Herbalist : Flora Health Canada What is the Microbiome? The community of microorganisms that inhabits our bodies Skin, mouth, nose, digestive tract, and
More informationHealth Benefits of Prebiotic Dietary Fiber
Health Benefits of Prebiotic Dietary Fiber JENNIFER ERICKSON, PhD, RD Objectives Provide some background on dietary fiber To define the term "prebiotic dietary fiber" To discuss potential health effects
More informationProbiotics: Their Role in Medicine Today. Objectives. Probiotics: What Are They? 11/3/2017
Probiotics: Their Role in Medicine Today Viki Barr Pharm.D., BCPS AQ ID Assistant Professor, Pharmacy Practice Rosalind Franklin University of Medicine and Science Clinical Pharmacist, Infectious Diseases
More informationShifts in the Intestinal Microbiota
Shifts in the Intestinal Microbiota Therapeutic Opportunities for Pre- and Probiotics? Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor Editor-in-Chief, Journal of
More informationTHE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME?
THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME? ALTERNATIVEMEDICINE.COM SUBCONSCIOUS SUGGESTION: WE TRY HYPNOTHERAPY The Color Run: 5 TIPS TO BEAT THE BUGS HORSES THAT
More informationProbiotic. Prebiotics:
Probiotic This product has been formulated using a blend of select prebiotics with a wide array of probiotics, designed to naturally strengthen the immune system. The organisms in this formula are synergistic
More informationProbiotics in Pediatric Health. AANP Annual Convention
Probiotics in Pediatric Health AANP Annual Convention Don Brown, ND July 12, 2017 Human Microbiome Richness and Metabolic Markers Human gut microbial composition was studied in 292 Danish adults Individuals
More informationThe number of microorganisms residing in our intestines is 10 times the number of our somatic and germ cells.
The number of microorganisms residing in our intestines is 10 times the number of our somatic and germ cells. The number of microorganisms residing in our intestines is 10 times the number of our somatic
More informationProbiotics and Prebiotics: Frequently Asked Questions
1. What are probiotics? Our intestines contain over 100 trillion bacteria. This is 1,000 times the number of cells that make up the entire human body. Many of these bacteria play an important role in protecting
More informationPROBIOTICS. The Ultimate Flora Difference
In the Refrigerator Section! PROBIOTICS High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion * The ReNew Life
More informationStudy summaries L. casei 431
This binder provides you with summaries of selected publications on Lactobacillus paracasei subsp. paracasei L. casei 431. The publications are clinical studies performed in humans documenting the effects
More informationObesity and microbiota: an example of an intricate relationship
Duranti et al. Genes & Nutrition (2017) 12:18 DOI 10.1186/s12263-017-0566-2 REVIEW Obesity and microbiota: an example of an intricate relationship Sabrina Duranti 1, Chiara Ferrario 1, Douwe van Sinderen
More informationMark Manary MD. International Symposium on Understanding Moderate Malnutrition in Children for Effective Interventions
Possible role of the microbiome in the development of acute malnutrition and implications for food-based strategies to prevent and treat acute malnutrition International Symposium on Understanding Moderate
More informationNatural and Holistic Medicine Approach in Evaluation and Treatment of Vaginal and Urinary Tract Health
Natural and Holistic Medicine Approach in Evaluation and Treatment of Vaginal and Urinary Tract Health By Dr. Michael John Badanek, BS, DC, CNS, CTTP, DACBN, DCBCN, MSGR./CHEV While the gut has an estimated
More informationIncreasing barrier function with multispecies probiotics
Increasing barrier function with multispecies probiotics Elsbeth Pekelharing, MSc Science Liaison We strive for the most effective microbiome management solutions with our evidence-based & indication-specific
More informationPROBIOTIC RESEARCH REVIEW
Probiotics in the Prevention of Eczema: A Randomised Controlled Trial (Allen at al. 2014) The probiotic formula that is used in GENESTRA BRANDS HMF Baby B and HMF Baby F was found to safely and effectively
More informationThe role of gut microbiome in IBS
The role of gut microbiome in IBS Chung Owyang, MD H. Marvin Pollard Professor of Internal Medicine Professor of Molecular and Integrative Physiology Chief, Division of Gastroenterology Director, Pollard
More informationThe Infant Gut Microbiome: Evidence for Obesity Risk and Dietary Intervention
Nutrients 2015, 7, 2237-2260; doi:10.3390/nu7042237 Review OPEN ACCESS nutrients ISSN 2072-6643 www.mdpi.com/journal/nutrients The Infant Gut Microbiome: Evidence for Obesity Risk and Dietary Intervention
More informationHOW THE MICROBIOME AFFECTS OUR HEALTH
HOW THE MICROBIOME AFFECTS OUR HEALTH THE INTESTINAL BARRIER AND INTESTINAL PERMEABILITY Intestinal Barrier: a functional body Defense from translocation of dietary antigens, bacteria or bacterial endotoxins
More informationHMF Probiotics PROFESSIONAL PRODUCT GUIDE
HMF Probiotics PROFESSIONAL PRODUCT GUIDE NEW New products inside Research-driven, proprietary, human-sourced strains Visit www.seroyal.com/genestrabrands to view the entire GENESTRA BRANDS line Dedicated
More informationVITAMINS, MINERALS AND THE GUT
VITAMINS, MINERALS AND THE GUT Nutrients Looking at individual nutrients that are involved with gut health can be misleading This is not about taking individual nutrients It supports more a whole food
More information9/25/2018 COPE WEBINAR SERIES FOR HEALTH PROFESSIONALS DID YOU USE YOUR PHONE TO ACCESS THE WEBINAR?
COPE WEBINAR SERIES FOR HEALTH PROFESSIONALS DID YOU USE YOUR PHONE TO ACCESS THE WEBINAR? September 26, 2018 The Gut Microbiome-Diabetes Connection Moderator: Lisa Diewald MS, RD, LDN Program Manager
More informationPROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND)
PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT Karen Jensen, (Retired ND) Today many people are aware of the benefits of maintaining a healthy gut. As a result, probiotic use is becoming ever more popular.
More informationIMMUNE TOLERANCE, ALLERGIES & THE GUT
IMMUNE TOLERANCE, ALLERGIES & THE GUT Foods and Sensitivity The food is not the issue No food is more susceptible to being an allergy or sensitivity than any other food There are three factors: 1.Frequency
More informationPROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora.
PROBIONA Probiotic supplement for adults PROBIOTICS with 5 bacterial strains Suitable during and after the use of antibiotics to restore intestinal microflora. 2.850 billion cfu per capsule guaranteed
More informationSlide 1 IMMUNE TOLERANCE, ALLERGIES & THE GUT. Slide 2 Foods and Sensitivity. Slide 3
Slide 1 IMMUNE TOLERANCE, ALLERGIES & THE GUT Slide 2 Foods and Sensitivity The food is not the issue No food is more susceptible to being an allergy or sensitivity than any other food There are three
More informationManipulating the gut microbiome
Manipulating the gut microbiome William DePaolo, PhD Associate Professor Medicine Director Center for Microbiome Sciences & Therapeutics University of Washington Microbiota The actual bugs that reside
More informationDysbiosis & Inflammation
MASTERING THE MICROBIOME: Dysbiosis & Inflammation 2017 Tom Fabian, PhD It is reasonable to propose that the composition of the microbiome and its activities are involved in most, if not all, of the biological
More information4/17/2019 DISCLOSURES OBJECTIVES GI MICROBIOME & HEALTH: A REVIEW. Nancy C. Kois, MD, FCAP Contemporary Pathology Services. There are no disclosures
GI MICROBIOME & HEALTH: A REVIEW Nancy C. Kois, MD, FCAP Contemporary Pathology Services DISCLOSURES There are no disclosures OBJECTIVES Definitions: GI microbiota, GI microbiome, probiotic, prebiotic
More informationFIBER HEALTH BENEFITS
FIBER FIBER HEALTH BENEFITS Normal Laxation: Increase stool weight from fiber, water retained by fiber and bacterial mass Eases defecation and prevents or relieves constipation Cereal fibers are best;
More informationPRODUCT PROSPECTUS. Probiotics and Prebiotics
PRODUCT PROSPECTUS Probiotics and Prebiotics 2 PURITY POTENCY PERFORMANCE PROBIOTICS AND PREBIOTICS Table of Contents The Klaire Labs Story 4-5 Section 1: Probiotics Reference Guide 6-7 Section 2: Probiotics
More informationTable S1. Overview of most studies on impact of ingested bacteria on human gut microbiota using methodologies not based on sequencing approaches
Supplementary Material Fate, activity, and impact of ingested bacteria within the human gut microbiota Muriel Derrien and Johan E.T. van Hylckama Vlieg Danone Nutricia Research, RD 128 Avenue de la Vauve,
More informationSeppo Salminen Mimi Tang
Koletzko B. (ed): Pediatric Nutrition in Practice. Basel, Karger, 2008, pp 80 84 1 General Aspects of Childhood Nutrition 1.8 Gut Microbiota in Infants Seppo Salminen Mimi Tang Key Words M i c r o b i
More informationNext generation of probiotics
Session: Evaluating next generation ingredients to support digestive health Wednesday 23 rd November 2016 Next generation of probiotics Louise R Wilson RD PhD Assistant Science Manager, Yakult UK Ltd LWilson@yakult.co.uk
More informationToday s talk 21/05/2017. Microbiota: the consequence of evolution! Probiotics and mucosal immunity interactions in early life.
Europe Probiotics and mucosal immunity interactions in early life Almere, 09 Mei, 2017 Today s talk The dynamics of the microbiota The required signals from the environment Not all signals (probiotics!)
More informationMicrobiome in You: Optimizing Gut Bacteria for Better IBD Management
Microbiome in You: Optimizing Gut Bacteria for Better IBD Management KT Park, M.D., M.S. Assistant Professor Co-Director, Stanford Children s Inflammatory Bowel Disease Center Stanford University School
More informationMICROBIOM AND OBESITY HEINZ GYAKY 2018 BUDAPEST
MICROBIOM AND OBESITY HEINZ GYAKY 2018 BUDAPEST HUMAN MICROBIOM 10 Billion bacterias are building a 1,5 2 kg heavy human microbiom It is located mainly in the human gut There is a intestinal controlled
More informationSYNBIOTIC EFFECTS DO THEY MAKE A DIFFERENCE?
SYNBIOTIC EFFECTS DO THEY MAKE A DIFFERENCE? Gail Cresci, PhD, RD, LD, CNSC Associate Staff Departments of Gastroenterology/Nutrition/Pathobiology Cleveland Clinic Cleveland, OH Objectives Discuss rationale
More informationAnalysis of the effect of probiotics on shaping human gut microbiota
Analysis of the effect of probiotics on shaping human gut microbiota Masahira HATTORI Center for Omics and Bioinformatics, The University of Tokyo http://www.cb.k.u-tokyo.ac.jp/hattorilab
More informationQ What are Probiotics?
Q What are Probiotics? The word PROBIOTIC was originated from Latin and means For Life. Probiotics are good bacteria usually found in food products or supplements which play very important roles in regulating
More informationTrend and Innovation of Pro and Prebiotics in Dairy Industry
Emerging Dairy Ingredients: Innovation, Safety & Functionality Bogor, 9 June 2011 Trend and Innovation of Pro and Prebiotics in Dairy Industry Lilis Nuraida Southeast Asia Food and Agricultural Science
More informationExamining the effects of pre and probiotics on gut microbiota during the ageing process
Session: Reviewing key ingredients shaping nutrition for healthy ageing Tuesday 22 nd November 2016 Examining the effects of pre and probiotics on gut microbiota during the ageing process Louise R Wilson
More informationINDEX. THT company history Your bacteria producer Probiotics - pure culture Probiotics - formulations and finished products...
1 INDEX THT company history... 03 Your bacteria producer... 04 Probiotics - pure culture... 05 Probiotics - formulations and finished products... 06 Packaging services... 06 Tailor made... 07 Prolactys...
More information11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic?
A Consumer s Guide to Probiotics and Health Wellness Wednesday November 2, 2016 Wendy Dahl RD PhD FDC Associate Professor, Food Science and Human Nutrition, UF/IFAS Objectives To outline current evidence
More informationPrebiotics, probiotics and synbiotics: An update
Prebiotics, probiotics and synbiotics: An update Natalie Schellack Professor, School of Pharmacy, Sefako Makgatho Health Sciences University Yolanda Combrinck Former academic intern, School of Pharmacy,
More informationHygiene Hypothesis: 10 years later. Christina Ciaccio MD, MSc Assistant Professor The University of Chicago
Hygiene Hypothesis: 10 years later Christina Ciaccio MD, MSc Assistant Professor The University of Chicago none Disclosures Definitions Microbe: Microscopic organism Microbiota: Microbial community Definition
More informationModule Four: The GI System Module Five: The Gut Microbiome. The GI System. LLiana Shanti, CN
Module Four: The GI System Module Five: The Gut Microbiome The GI System LLiana Shanti, CN www.healthmasteryinstitute.com Review Review Review The Gut Hippocrates has been quoted as saying death sits in
More informationMicrobiome GI Disorders
Microbiome GI Disorders Prof. Ram Dickman Neurogastroenterology Unit Rabin Medical Center Israel 1 Key Points Our gut microbiota Were to find them? Symbiosis or Why do we need them? Dysbiosis or when things
More informationUNDERSTANDING PROBIOTIC SUPPLEMENTS
UNDERSTANDING PROBIOTIC SUPPLEMENTS Probiotics Health Canada Definition: Probiotics are considered to be live microorganisms which, when administered in adequate amounts, confer a health benefit on the
More informationThe Enigma of the Infant Microbiome
The Enigma of the Infant Microbiome 3 rd Microbiome R&D and Business Collaboration Forum Europe London, April 2016 David J. Kyle, CEO, Evolve Biosystems Inc Microbiome diversity is a good thing. Modern
More informationUNDERSTANDING PROBIOTIC SUPPLEMENTS
Slide 1 UNDERSTANDING PROBIOTIC SUPPLEMENTS Slide 2 Probiotics Health Canada Definition: Probiotics are considered to be live microorganisms which, when administered in adequate amounts, confer a health
More information7/30/2018. Nutricia North America 1. Learning Objectives
Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease Kelly Tappenden, Ph.D, R.D. Kelly Tappenden, Ph.D, R.D. Professor and Department Head Department of
More informationResearch and development new symbiotic product and its clinical effect
Research and development new symbiotic product and its clinical effect Almagul Kushugulova, DMSc, akushugulova@nu.edu.kz Center for Life Sciences, Nazarbayev University, Astana, Kazakhstan First stage:
More informationHealthy Gut, Healthy Body
September 2018 Healthy Gut, Healthy Body Science tells us that the bacteria in our bodies outnumber our cells 10 to 1. And it s supposed to be that way. Research has shown that the human microbiome, an
More informationProbiotics. NOW Guide to Probiotics
Probiotics NOW Guide to Probiotics The Health Benefits of Probiotics Microorganisms for Health Did you know that you have trillions of microorganisms, including bacteria and yeast, living in and on your
More informationLactobacillus bulgaricus
probiotic Lactobacillus bulgaricus Danone " : : * * * * * Bifidobacterium (LactobacillusCG) (Saccharomyce) (Bifidobacterium) (Antibiotic related diarrhea) GG L (Cytoprotection) B IgA lgg Probiotics -
More informationThe vital role of the microbiome in human health
The vital role of the microbiome in human health abandoning hygiene is not the way to a healthy microbiome Colin Hill APC Microbiome Institute University College Cork @colinhillucc Mixed messages? We live
More informationFactors Influencing the Vaginal Microbiome and its Impact on Feminine Health and Wellness
Factors Influencing the Vaginal Microbiome and its Impact on Feminine Health and Wellness Lindsay Peed, Ph.D. Cindy Korir-Morrison, Ph.D. Rebecca Vongsa, Ph.D. David Koenig, Ph.D. Corporate Research &
More informationGovernment Gazette Staatskoerant
Government Gazette Staatskoerant REPUBLIC OF SOUTH AFRICA REPUBLIEK VAN SUID AFRIKA Regulation Gazette No. 10177 Regulasiekoerant Vol. 629 14 November November 2017 No. 41248 N.B. The Government Printing
More informationUnderstanding probiotics and health
Understanding probiotics and health Gemma Laws MSc Student Microbiology and Immunology Department The gut microbiota The name given to the total microbial population living in our intestine Bacteria, fungi,
More informationModule Outline. 1. Microbiome overview: getting a sense of the microbiome, research, what we know
Module Outline 1. Microbiome overview: getting a sense of the microbiome, research, what we know 2. Bacteria: features, functions, communities & taxonomy 3. Other microbes: archaea, fungi, viruses, parasites
More informationGut Lung Axis Implication of the Gut Microbiota beyond its niche
Gut Lung Axis Implication of the Gut Microbiota beyond its niche Reema Subramanian PhD Candidate (4 th year) Supervisor: Prof. Margaret Ip Department of Microbiology, CUHK Joint Graduate Student Seminar
More informationProbiotics in the ICU. Who could benefit? Nadia J van Rensburg RD(SA) Groote Schuur Hospital, Cape Town
Probiotics in the ICU. Who could benefit? Nadia J van Rensburg RD(SA) Groote Schuur Hospital, Cape Town Outline Introduction: a brief overview Probiotics: Current guidelines Reviews and Meta-analyses IBD
More informationTOP 10 LEAKY GUT SUPPLEMENTS
TOP 10 LEAKY GUT SUPPLEMENTS HEALING LEAKY GUT Leaky Gut Supplements Leaky gut syndrome is a condition where undigested proteins like gluten, toxins and microbes can pass into the bloodstream. Another
More informationTher-Biotic Complete. Broad-spectrum synergistic multispecies probiotic formula. Supporting essential intestinal microdiversity
Ther-Biotic Complete Broad-spectrum synergistic multispecies probiotic formula Supporting essential intestinal microdiversity Ther-Biotic Complete Broad-spectrum synergistic multispecies probiotic formula
More informationAnything You Can Do I Can Do Better: Divergent Mechanisms to Metabolize Milk Oligosaccharides by Two Bifidobacterial Species. David A.
Anything You Can Do I Can Do Better: Divergent Mechanisms to Metabolize Milk Oligosaccharides by Two Bifidobacterial Species David A. Sela IMGC 2013 This is not our planet Bacteria present by 3.9 bya Archaea
More informationINTESTINAL MICROBIOTA EXAMPLES OF INDIVIDUAL ANALYSES
EXAMPLES OF INDIVIDUAL ANALYSES INTESTINAL MICROBIOTA Microbiota in the animal or human intestine has evolved together with the host. Consequently, the gastrointestinal tract could be considered a metacommunity,
More informationProbiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease. Kelly Tappenden, Ph.D, R.D.
Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease Kelly Tappenden, Ph.D, R.D. Kelly Tappenden, Ph.D, R.D. Professor and Department Head Department of
More informationProbiotics and Health
Probiotics and Health March 2015 TABLE OF CONTENTS EXECUTIVE SUMMARY... 2 BACKGROUND AND DEFINITIONS... 4 FUNCTIONAL GASTROINTESTIINAL DISORDERS... 5 Irritable bowel syndrome... 5 Constipation... 6 INFLAMMATORY
More informationMicrobiome. The Gut Microbiome function 3/6/2018. Use of probiotics for management of various GI conditions
Use of probiotics for management of various GI conditions Lina Kay PA-C Arizona Gastroenterology Associates Scottsdale, AZ Microbiome Human GI tract hosts countless microbes (estimate 100 trillions bacteria
More informationSlide 1. Slide 2 Learning outcomes. Slide 3. Year 1 MBChB Lecture 15 Introduction to the Gut Microbiota. The importance of microbiota
Slide 1 Year 1 MBChB Lecture 15 Introduction to the Gut Microbiota Professor Barry Campbell Gastroenterology Research Unit Cellular & Molecular Physiology, Institute of Translational Medicine bjcampbl@liv.ac.uk
More informationROLE OF THE GUT BACTERIA
ROLE OF THE GUT BACTERIA Our Good Bacteria In a perfect world, we would all have a proper ratio of good bacteria And what could this proper ratio do for us? The knowledge of the connections between our
More informationProbiotics. Wide spectrum of important health benefits
Probiotics Part 1: What Are Probiotics? Probiotics are live microorganisms that inhabit the respiratory and gastrointestinal tracts and the skin. They are often referred to as friendly bacteria as they
More informationMegaSporeBiotics Probiotics. Linda Wilbert - Stewart, FDN, HHP, HC 1/28/
MegaSporeBiotics Probiotics www.exclusivelyholistic.com Linda Wilbert - Stewart, FDN, HHP, HC 1/28/2015 111 MegaSporeBiotic is the first, all spore, carotenoid rich, probiotic consortium formulation on
More informationDiet, Microbiome and Health Cindy D. Davis
Diet, Microbiome and Health Cindy D. Davis davisci@mail.nih.gov OFFICE OF DIETARY SUPPLEMENTS 1 Outline 1.What is the microbiome? 2.How does it vary over the lifespan? 3.What is the evidence that diet
More informationMicrobiome and liver diseases
Klinik und Poliklinik für Innere Medizin I Microbiome and liver diseases Bernd Schnabl, M.D. Department of Medicine I have no financial relationship relevant to my presentation AND my presentation does
More informationLaboratory report. Test: Leaky gut test. Sample material: stool. John Doe Main St 1 Anytown
1 / 5 Verisana LAB John Doe Main St 1 Anytown Surname, First name Doe, John DOB 02/13/1980 Sex male Laboratory # 20020181 Date collected 01/25/2018 Date received 02/01/2018 Report date 02/13/2018 Laboratory
More informationMicrobial Fermentation, SCFA Absorption and Further Metabolism by Host. Karen Scott
Microbial Fermentation, SCFA Absorption and Further Metabolism by Host Karen Scott SCFA metabolism section Contributors Bert Groen Gilles Mithieux Elaine Vaughan Karen Scott Functions of the gut microbiota
More information6/19/2017 OBJECTIVES. Describe the proposed mechanism(s) between the gut microbiome and psychiatric disease.
OBJECTIVES Describe the proposed mechanism(s) between the gut microbiome and psychiatric disease. List psychiatric diseases that have been associated with alterations in gut microbiota. Describe the strength
More informationULTIMATE FLORA PROBIOTICS
ULTIMATE FLORA PROBIOTICS In the Refrigerator Section! High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion*
More informationProbiotics: Implications for Pediatric Health
Probiotics: Implications for Pediatric Health PREFACE It is no longer questioned that the interplay between our genes, nutrition, and our environment hold the keys to growth, development, and health.
More information