Medication-Related Osteonecrosis of the Jaws

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1 Medication-Related Osteonecrosis of the Jaws

2

3 Sve n O t to Editor Medication-Related Osteonecrosis of the Jaws Bisphosphonates, Denosumab, and New Agents

4 Editor Sven Otto, MD, DMD, FEBOMFS Department of Oral and Maxillofacial Surgery Ludwig-Maximilians-University of Munich Munich Germany ISBN ISBN (ebook) DOI / Springer Heidelberg New York Dordrecht London Library of Congress Control Number: Springer-Verlag Berlin Heidelberg 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (

5 Foreword What began as a link between intravenous bisphosphonates in cancer patients and osteonecrosis of the jaw has greatly expanded to a definitive causation from two intravenous bisphosphonates as well as several oral bisphosphonates for osteoporosis patients and a RANK ligand inhibitor for either cancer patients or osteoporosis patients. Furthermore, the route of administration for the RANK ligand inhibitors is subcutaneous rather than intravenous or oral. Adding to the complexity of jaw osteonecrosis are more rare reports from drugs which inhibit the vascular endothelial growth factor and others which inhibit certain tyrosine kinase receptors as their main mechanism of action. The textbook Medication-Related Osteonecrosis of the Jaws : Bisphosphonates, Denosumab, and New Agents by Sven Otto explores the science, pharmacodynamics, diagnosis, and treatment options in a complete and comprehensive manner. Each chapter contains extensive evidence-based as well as experience-based data designed to help the reader fully understand the nuances of this complex and interesting disease as well as how it can be managed and many times resolved. Sven Otto himself has been one of the pioneers and leaders internationally that brought to clinicians a clearer understanding of this complex pathophysiology. Together with the experience and expertise of each chapter author, this text becomes a required read and one that serves as a reference that helps everyone in the treatment of osteonecrosis of the jaw. As a recognized disease entity in the published literature, osteonecrosis of the jaw was unheard of prior to In just a few years, it has become a condition seen in nearly every dental office throughout the world. While this book thoroughly prepares the reader related to the current drugs causing osteonecrosis of the jaw, new targeted drugs are coming to the marketplace with similar and profound effects on normal cellular functions. Only the naïve would think we have seen the last of jaw osteonecrosis. FL, USA Robert E. Marx, DDS v

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7 Contents 1 Pharmacological Aspects of Antiresorptive Drugs: Bisphosphonates and Denosumab Reiner Bartl and Emmo von Tresckow 2 Bisphosphonate and Denosumab Therapy: Fields of Application Cornelia Then, Emmo von Tresckow, Reiner Bartl, and Fuat S. Oduncu 3 Risk Factors for Medication-Related Osteonecrosis of the Jaw Tae-Geon Kwon 4 Defi nition, Clinical Features and Staging of Medication- Related Osteonecrosis of the Jaw Sven Otto, Tae-Geon Kwon, and Alexandre Th. Assaf 5 Epidemiology of Medication-Related Osteonecrosis of the Jaw Towy Sorel Lazarovici and Tal Yoffe 6 Imaging Modalities and Characteristics in Medication-Related Osteonecrosis of the Jaw Florian A. Probst, Monika Probst, and Sotirios Bisdas 7 Treatment of Medication-Related Osteonecrosis of the Jaw Christoph Pautke 8 Local and Microvascular Free Flaps in Patients with Medication-Related Osteonecrosis of the Jaw Thomas Mücke and David A. Mitchell 9 Adjuvant Treatment Options in the Management of Medication-Related Osteonecrosis of the Jaw Paolo Vescovi, Maddalena Manfredi, and Elisabetta Merigo vii

8 viii Contents 10 New and Innovative Treatment Strategies for Medication-Related Osteonecrosis of the Jaw Riham M. Fliefel and Pit J. Voss 11 Microbiology and Antibiotics in the Context of Medication-Related Osteonecrosis of the Jaw Sebastian Hoefert 12 Histopathology of Medication-Related Osteonecrosis of the Jaw Risa Chaisuparat and Bruno C. Jham 13 Pathogenesis of Medication-Related Osteonecrosis of the Jaw Sven Otto, Jose Ignacio Aguirre, Ezher Dayisoylu, and Thomas Ziebart 14 Risk Reduction of Medication-Related Osteonecrosis of the Jaw Noam Yarom and Stefano Fedele 15 Animal Models of Medication-Related Osteonecrosis of the Jaw Matthew R. Allen 16 Dental Rehabilitation in Patients Receiving Antiresorptive Drugs Sebastian Hoefert, Feraydoon Sharghi, and Eva Engel 17 Dental Implants in the Context Antiresorptive Drugs and Medication-Related Osteonecrosis of the Jaw Yorck Alexander Zebuhr 18 Osteonecrosis of the Jaw in Association with Targeted Therapy Matthias Troeltzsch, Markus Troeltzsch, Christoph Pache, and Timothy Woodlock 19 History of Osteonecrosis of the Jaw Sebastian Hoefert, Claudia Sade Hoefert, and Martin Widmann 20 Future Perspectives of Bisphosphonates in Maxillofacial, Dental, and Medical Practice Ralf Smeets, Henning Hanken, Ole Jung, and Max Heiland Index

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