EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT EE
|
|
|
- Benjamin Horatio Whitehead
- 5 years ago
- Views:
Transcription
1 Pathology report by BAKO PATHOLOGY SERVICES EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT EE Patient Information: 83-year-old female 68% increase in nerve fiber density Physician: Kevin F Sunshein, DPM Neurogenx NerveCenter of Centerville 6474 Centerville Business Pkwy Centerville, OH Before Neurogenx Treatment - 02/02/16 After Neurogenx Treatment - 09/09/16 A. SKIN, RIGHT CALF, PUNCH BIOPSY: Intra-epidermal nerve counts in normative range (10.30 Fibers/mm). Mild morphologic degenerative changes are seen among intra-epidermal nerve fibers. (See Comment 1). A. SKIN, RIGHT CALF, PUNCH BIOPSY: Intra-epidermal nerve counts in normative range (17.31 Fibers/mm). This study demonstrates an increase in epidermal nerve fiber density relative to this patient s previous study. (See comment 3). B. SKIN, LEFT CALF, PUNCH BIOPSY: Intra-epidermal nerve fiber density is borderline low (7.97 Fibers/mm). Papillary dermal nerve fibers atretic and slightly diminished. ( See Comment 2). B. SKIN, LEFT CALF, PUNCH BIOPSY: Intra-epidermal nerve counts in normative range (13.93 Fibers/mm). This study demonstrates an increase in epidermal nerve fiber density relative to this patients previous study. ( See Comment 3). Final Diagnosis performed by Wayne L. Bakotic D.O. Electronically signed 2/8/2016 Final Diagnosis performed by Wayne L. Bakotic D.O. Electronically signed 9/15/2016 BAKO PATHOLOGY SERVICES 6240 Shiloh Road, Alpharetta, GA Phone: Page 1 of 2
2 Pathology report by BAKO PATHOLOGY SERVICES EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT EE Patient Information: 83-year-old female 68% increase in nerve fiber density Physician: Kevin F Sunshein, DPM Neurogenx NerveCenter of Centerville 6474 Centerville Business Pkwy Centerville, OH COMMENT 1: Immunohistochemical studies using anti-pgp 9.5 antibodies; and subsequent morphometric analysis, disclose a density of epidermal nerve fibers that is well within the published normative range. This finding militates strongly against established small fiber neuropathy (sensitivity approaching 90%). This biopsy does, however, disclose degenerative changes within epidermal nerves. These changes are not entirely specific and may be seen in some normal subjects; however, these findings are often predictive of the future development of clinical neuropathy. Because there is no definitive evidence of established small fiber peripheral neuropathy in the current biopsy, but significant degenerative changes are seen, should symptoms persist, an additional biopsy in 6-12 months could be beneficial to assess for disease progression. COMMENT 2: Immunohistochemical studies and morphometric analysis disclose a low-normal number of all small myelinated (A-delta) and unmyelinated (C) nerve fibers within the epidermis. In addition, fibers within the papillary dermis are atretic and slightly diminished. The depressed number of fibers following immunohistochemical analysis using anti-pgp 9.5 antibodies could be indicative of early-evolving small fiber neuropathy. The published specificity below the fifth percentile, (less than 3.8 fibers/mm), is 97% (in the context of an appropriately fixated post-biopsy specimen). Reference: Ebenezer GJ, P Hauer, C Gibbons, et al. J Neuropathol Exp Neurol 66(12): , COMMENT 3: Immunohistochemical studies and morphometric analysis disclose a density of small myelinated (A-delta) and unmyelinated (C) nerve fibers that is within the published normative range. The presence a normal intra-epidermal nerve fiber density following immunohistochemical analysis using anti-pgp 9.5 antibodies militates strongly against advanced small fiber neuropathy; however, such cannot be entirely excluded (sensitivity 70-90%). Reference: Ebenezer GJ, P Hauer, C Gibbons, JC McArthur, M Polydefkis. Assessment of epidermal nerve fibers: a new diagnostic and predictive tool for peripheral neuropathy. J Neuropathol Exp Neurol 66(12): , BAKO PATHOLOGY SERVICES 6240 Shiloh Road, Alpharetta, GA Phone: Page 2 of 2
3 Pathology report by BAKO PATHOLOGY SERVICES EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT RS Patient Information: 79-year-old male An average increase of % in nerve fiber density. Physician: Kevin F Sunshein, DPM Neurogenx NerveCenter of Centerville 6474 Centerville Business Pkwy Centerville, OH Before Neurogenx Treatment - 12/03/15 After Neurogenx Treatment - 12/12/16 A. SKIN, RIGHT CALF, PUNCH BIOPSY: Intra-epidermal nerve fiber density is moderately decreased (2.24 Fibers/mm). Papillary dermal nerve fibers atretic and diminished. (See Comment 1). A. SKIN, RIGHT CALF, PUNCH BIOPSY: Intra-epidermal nerve density low-normal/borderline (7.51 Fibers/mm). Mild morphologic degenerative changes are seen among intra-epidermal nerve fibers. (See Comment 3) to 7.51 is an increase of % B. SKIN, LEFT CALF, PUNCH BIOPSY: Intra-epidermal nerve fiber density severely decreased (epidermis essentially devoid of fibers: 1.19 Fibers/mm). Papillary dermal nerve fibers profoundly diminished. ( See Comment 2). B. SKIN, LEFT CALF, PUNCH BIOPSY: Intra-epidermal nerve density within the normative range (10.21 Fibers/mm). Mild morphologic degenerative changes are seen among intra-epidermal nerve fibers. ( See Comment 4) to is an increase of % Final Diagnosis performed by Wayne L. Bakotic D.O. Electronically signed 12/15/2015 Final Diagnosis performed by Wayne L. Bakotic D.O. Electronically signed 12/16/2016 BAKO PATHOLOGY SERVICES 6240 Shiloh Road, Alpharetta, GA Phone: Page 1 of 2
4 Pathology report by BAKO PATHOLOGY SERVICES EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT RS Patient Information: 79-year-old male An average increase of % in nerve fiber density. Physician: Kevin F Sunshein, DPM Neurogenx NerveCenter of Centerville 6474 Centerville Business Pkwy Centerville, OH COMMENT 1: Immunohistochemical studies and morphometric analysis disclose a moderate decreased in the number of small myelinated (A-delta) and unmyelinated (C) nerve fibers within the epidermis. In addition, fibers within the papillary dermis are atretic and diminished in number. The depressed number of fibers following immunohistochemical analysis using anti-pgp 9.5 antibodies is indicative of established small fiber neuropathy**. The published specificity below the fifth percentile, (less than 3.8 fibers/mm), is 97% (in the context of an appropriately fixated post-biopsy specimen). Reference: Ebenezer GJ, P Hauer, C Gibbons, et al. J Neuropathol Exp Neurol 66(12): , COMMENT 2: Immunohistochemical studies and morphometric analysis disclose a severe loss of small myelinated (A-delta) and unmyelinated (C) nerve fibers within the epidermis. In addition, fibers within the papillary dermis are atretic and greatly diminished. The utter absence of fibers following immunohistochemical analysis using anti-pgp 9.5 antibodies is indicative of advanced small fiber neuropathy**. The published specificity below the fifth percentile, (less than 3.8 fibers/mm), is 97% (in the context of an appropriately fixated post-biopsy specimen). Reference: Ebenezer GJ, P Hauer, C Gibbons, et al. J Neuropathol Exp Neurol 66(12): , COMMENT 3: Immunohistochemical studies using anti-pgp 9.5 antibodies; and subsequent morphometric analysis, disclose a density of epidermal nerve fibers that is within the normative range for this anatomic location; however, it scarcely reaches that threshold (7.1 fibers/mm is the lower limit of normal range). In light of the clinical history in this case, this test suggests significant improvement from the patient s prior small fiber density status. We have found the persistence of degenerative changes in cases such as these to be commonplace. Their significance has not been adequately studied; however, could be a reflection of the patients overall medical status. COMMENT 4: Immunohistochemical studies using anti-pgp 9.5 antibodies; and subsequent morphometric analysis, disclose a density of epidermal nerve fibers that is within the normative range for this anatomic location (counts reach the threshold of 7.1 fibers/mm. The density in the current biopsy militates against the presence of established small fiber neuropathy (sensitivity approaching 90%) at this point in time. In light of the clinical history in this case, this analysis suggests significant improvement from the patient s prior small fiber density status. We have found the persistence of degenerative changes in cases such as these to be commonplace. Their significance has not been adequately studied; however, could be a reflection of the patients overall medical status. BAKO PATHOLOGY SERVICES 6240 Shiloh Road, Alpharetta, GA Phone: Page 2 of 2
5 Pathology report by Advanced Laboratory Services EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT JM Patient Information: Name: JM 66% increase in nerve fiber density Physician: Steven Weinshel, MD, JD Neurogenx NerveCenter of St. Petersburg th Avenue North St. Petersburg, FL Before Neurogenx Treatment - 10/21/15 After Neurogenx Treatment - 6/21/16 A. SPECIMEN PUNCH SITE LEFT DISTAL LEG: The epidermal nerve fiber density estimate is 2.5 fibers/mm (normal > 2.1 fibers/mm). A. SPECIMEN PUNCH SITE LEFT DISTAL LEG: The epidermal nerve fiber density estimate is 4.14 fibers/mm (abnormal < 2.5 fibers/mm; low normal value range = ). Advanced Laboratory Services Inc. 501 Elmwood Ave., Sharon Hill, PA Phone
6 Pathology report by Advanced Laboratory Services EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT LR Patient Information: 69-year old male Overall average increase in nerve fiber density of % Before Neurogenx Treatment - 02/22/16 Physician: Baker-Belscher, Carol, ARNP Neurogenx NerveCenter of St. Petersburg th Avenue North St. Petersburg, FL After Neurogenx Treatment - 01/16/17 A. SPECIMEN PUNCH SITE RIGHT DISTAL LEG: The epidermal nerve fiber density estimate is 0.1 fibers/mm (normal > 2.8 fibers/mm). A. SPECIMEN PUNCH SITE RIGHT DISTAL LEG: The epidermal nerve fiber density estimate is 6.73 fibers/mm (abnormal < 2.7 fibers/mm; low normal value range = ). 0.1 to 6.73 is an increase of 6630% B. SPECIMEN PUNCH SITE RIGHT DISTAL THIGH: The epidermal nerve fiber density estimate is 1.8 fibers/mm (normal > 7.0 fibers/mm). B. SPECIMEN PUNCH SITE RIGHT DISTAL THIGH: The epidermal nerve fiber density estimate is 2.69 fibers/mm (abnormal < 6.2 fibers/mm; low normal value range = ). 1.8 to 2.69 is an increase of 49.44% Case reviewed with generated report by Michael Stanton, MD at the University of Rochester 601 Elmwood Ave. Rochester, NY Case reviewed with generated report by Charles Shao, MD at Therapath Neuropathology 545 West 45th Street, New York, NY Advanced Laboratory Services Inc. 501 Elmwood Ave., Sharon Hill, PA Phone
7 Pathology report by Advanced Laboratory Services EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT SM Patient Information: 73-year-old male Overall average increase in nerve fiber density = 42.45% Physician: Steven Weinshel, MD, JD Neurogenx NerveCenter of St. Petersburg th Avenue North St. Petersburg, FL Before Neurogenx Treatment - 02/23/16 After Neurogenx Treatment - 08/15/16 A. RIGHT DISTAL LEG: The epidermal nerve fiber density estimate is 0.0 fibers/mm (normal > 2.1 fibers/mm). A. RIGHT DISTAL LEG: The epidermal nerve fiber density estimate is 0.34 fibers/ mm (abnormal < 2.5 fibers/mm; low normal value range = ). 33.9% increase in nerve fiber density. B. RIGHT DISTAL THIGH The epidermal nerve fiber density estimate is 4.0 fibers/mm (normal > 7.0 fibers/mm). B. RIGHT DISTAL THIGH: The epidermal nerve fiber density estimate is 6.04 fibers/ mm (abnormal < 6.2 fibers/mm; low normal value range = ). 51% increase in nerve fiber density. Case reviewed with generated report by David Herrmann, MD at the University of Rochester 601 Elmwood Ave. Rochester, New York Case reviewed with generated report by Codrin Lacob, MD at Therapath Neuropathology, 545 West 45th Street, New York, NY Advanced Laboratory Services Inc. 501 Elmwood Ave., Sharon Hill, PA Phone Page 1 of 2
8 Pathology report by Advanced Laboratory Services EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT SM Patient Information: 73-year-old male Overall average increase in nerve fiber density = 42.45% Physician: Steven Weinshel, MD, JD Neurogenx NerveCenter of St. Petersburg th Avenue North St. Petersburg, FL Before Neurogenx Treatment - 02/23/16 After Neurogenx Treatment - 08/15/16 DIAGNOSIS: (A, B) SKIN, RIGHT DISTAL LEG AND RIGHT DISTAL THIGH, BIOPSIES (PROCEDURE DATE 2/23/2016): CONSISTENT IN THE APPROPRIATE CLINICAL SETTING WITH A SEVERE LENGTH-DEPENDENT NEUROPATHY AFFECTING UNMYELINATED SENSORY FIBERS. CLINICAL HISTORY: Burning/tingling sensations GROSS DESCRIPTION: A Specimen received in cryoprotectant following Zamboni s fixation. Received in one vial labeled Right Distal Leg. It consists of a soft tan punch biopsy of skin measuring 3 mm in diameter by 3 mm. B. Specimen received in cryoprotectant following Zamboni s fixation. Received in one vial labeled Right Distal Thigh. It consists of a soft tan punch biopsy of skin measuring 3 mm in diameter by 3 mm. MICROSCOPIC DESCRIPTION: A) Right Distal Leg: Epidermal nerve fibers (PGP 9.5 immunostaining) are almost absent in these sections. The epidermal nerve fiber density estimate is 0.0 fibers/mm (normal > 2.1 fibers/mm). Morphologic analysis shows excessively segmented immunoreactivity of some remaining sub-epidermal nerve fibers. B) Right Distal Thigh: Epidermal nerve fiber density (PGP 9.5 immunostaining) is reduced. The epidermal nerve fiber density estimate is 4.0 fibers/mm (normal > 7.0 fibers/mm). Morphologic analysis shows a focal area of large axonal swellings. Positive controls for IHC were evaluated and are adequate for diagnosis. DIAGNOSIS: A. RT DISTAL LEG, SKIN BIOPSY: SKIN WITH SIGNIFICANTLY REDUCED EPIDERMAL NERVE FIBER DENSITY, CONSISTENT WITH SMALL FIBER NEUROPATHY. B. RT DISTAL THIGH, SKIN BIOPSY: COUNT ONLY. SEE COMMENT. C. RT PROXIMAL THIGH, SKIN BIOPSY: SKIN WITH SIGNIFICANTLY REDUCED EPIDERMAL NERVE FIBER DENSITY, CONSISTENT WITH SMALL FIBER NEUROPATHY. CLINICAL HISTORY: Numbness/paresthesias GROSS DESCRIPTION: A. Specimen received in cryoprotectant following Zamboni s fixation. Received in one vial labeled Right Distal Leg. It consists of a soft tan punch biopsy of skin measuring 3 mm in diameter by 1.5 mm. B. Specimen received in cryoprotectant following Zamboni s fixation. Received in one vial labeled Right Distal Thigh. It consists of a soft tan punch biopsy of skin measuring 3 mm in diameter by 2 mm. C. Specimen received in cryoprotectant following Zamboni s fixation. Received in one vial labeled Right Proximal Thigh. It consists of a soft tan punch biopsy of skin measuring 3 mm in diameter by 3 mm. MICROSCOPIC DESCRIPTION: A. Right Distal Leg: From the samples that have been tested, there is no evidence of vasculitis or other histological abnormalities based on the H&E stain. Many disorders, including vasculitis, are focal and this analysis does not exclude the diagnosis. There is almost complete depletion of nerve fibers in the subepithelial neural plexus. B. Right Distal Thigh: From the samples that have been tested, there is no evidence of vasculitis or other histological abnormalities based on the H&E stain. Many disorders, including vasculitis, are focal and this analysis does not exclude the diagnosis.there is almost complete depletion of nerve fibers in the subepithelial neural plexus. C. Right Proximal Thigh: From the samples that have been tested, there is no evidence of vasculitis or other histological abnormalities based on the H&E stain. Many disorders, including vasculitis, are focal and this analysis does not exclude the diagnosis. Advanced Laboratory Services Inc. 501 Elmwood Ave., Sharon Hill, PA Phone Page 2 of 2
EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT EE
Pathology report by BAKO PATHOLOGY SERVICES EPIDERMAL NERVE FIBER DENSITY ANALYSIS OF PATIENT EE Patient Information: 83-year-old female 68% increase in nerve fiber density Physician: Kevin F Sunshein,
Epidermal Nerve Fiber and Schwann cell densities in the distal leg of Nine-banded Armadillos with Experimental Leprosy neuropathy
Epidermal Nerve Fiber and Schwann cell densities in the distal leg of Nine-banded Armadillos with Experimental Leprosy neuropathy Gigi J Ebenezer 1 Richard Truman 2 David Scollard 2 Michael Polydefkis
Clinical Policy Title: Epidermal nerve fiber density testing
Clinical Policy Title: Epidermal nerve fiber density testing Clinical Policy Number: CCP.1263 Effective Date: January 1, 2017 Initial Review Date: October 19, 2016 Most Recent Review Date: October 2, 2018
University of Utah. Cutaneous Nerve Evaluation. Please read through all information BEFORE scheduling patient s biopsy
University of Utah Cutaneous Nerve Evaluation Please read through all information BEFORE scheduling patient s biopsy Now 1) Open the enclosed kit and FREEZE the cold pack for return shipment 2) Keep everything
Corporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: nerve_fiber_density_testing 2/2010 10/2016 10/2017 10/2016 Description of Procedure or Service Skin biopsy
UTILITY OF SKIN BIOPSY IN MANAGEMENT OF SMALL FIBER NEUROPATHY
UTILITY OF SKIN BIOPSY IN MANAGEMENT OF SMALL FIBER NEUROPATHY SCOTT A. BORUCHOW, MD, and CHRISTOPHER H. GIBBONS, MD, MMSc Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel
Diabetic Complications Consortium
Diabetic Complications Consortium Application Title: Cathepsin S inhibition and diabetic neuropathy Principal Investigator: Nigel A Calcutt 1. Project Accomplishments: We investigated the efficacy of cathepsin
Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy
Because the breeder pairs, which never produced myotonic offspring in the same colony, showed the same nucleotide substitutions in the ClC-1, we concluded that these nucleotide substitutions seen in the
Clinical Policy Title: Epidermal nerve fiber density testing
Clinical Policy Title: Epidermal nerve fiber density testing Clinical Policy Number: 09.01.12 Effective Date: January 1, 2017 Initial Review Date: October 19, 2016 Most Recent Review Date: October 19,
Diagnosis of Reflex Sympathetic Dystrophy/ Complex Regional Pain Syndrome and Small Fiber Neuropathy
PRINTER-FRIENDLY VERSION AT PAINMEDICINENEWS.COM Diagnosis of Reflex Sympathetic Dystrophy/ Complex Regional Pain Syndrome and Small Fiber Neuropathy TODD LEVINE, MD Clinical Associate Professor University
Clinical Policy Title: Epidermal nerve fiber density testing
Clinical Policy Title: Epidermal nerve fiber density testing Clinical Policy Number: 09.01.12 Effective Date: January 1, 2017 Initial Review Date: October 19, 2016 Most Recent Review Date: October 19,
Epidermal Nerve Fiber Length Density Estimation Using Global Spatial Sampling in Healthy Subjects and Neuropathy Patients
J Neuropathol Exp Neurol Copyright Ó 2013 by the American Association of Neuropathologists, Inc. Vol. 72, No. 3 March 2013 pp. 186Y193 ORIGINAL ARTICLE Epidermal Nerve Fiber Length Density Estimation Using
Thank you to: L Magy, L Richard, N Couade, F Maquin
«Crash course in the interpretation of peripheral nerve biopsies: which nerve to biopsy, tissue fixation: paraffin, semi thins, EM (common stains and immunos), identifying degenerating and regenerating
Nerve Fiber Density Testing. Description
Subject: Nerve Fiber Density Testing Page: 1 of 13 Last Review Status/Date: December 2014 Nerve Fiber Density Testing Description Skin biopsy is used to assess the density of epidermal (intraepidermal)
Nerve Fiber Density Measurement
Nerve Fiber Density Measurement Policy Number: Original Effective Date: MM.02.020 11/01/2013 Line(s) of Business: Current Effective Date: HMO; PPO; QUEST Integration 05/25/2018 Section: Medicine Place(s)
Nerve Fiber Density Testing
Applies to all products administered or underwritten by Blue Cross and Blue Shield of Louisiana and its subsidiary, HMO Louisiana, Inc.(collectively referred to as the Company ), unless otherwise provided
EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy
European Journal of Neurology 2005, 12: 747 758 EFNS TASK FORCE/CME ARTICLE EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy G. Lauria a, D. R. Cornblath b, O. Johansson
ORIGINAL CONTRIBUTION. Small-Fiber Neuropathy/Neuronopathy Associated With Celiac Disease
ORIGINAL CONTRIBUTION Small-Fiber Neuropathy/Neuronopathy Associated With Celiac Disease Skin Biopsy Findings Thomas H. Brannagan III, MD; Arthur P. Hays, MD; Steven S. Chin, MD, PhD; Howard W. Sander,
Nerve Fiber Density Testing
Nerve Fiber Density Testing Policy Number: Original Effective Date: MM.02.020 11/01/2013 Line(s) of Business: Current Effective Date: HMO; PPO; QUEST Integration 03/28/2014 Section: Medicine Place(s) of
Comparison of Sudomotor and Sensory Nerve Testing in Painful Sensory Neuropathies
138 Original Article Comparison of Sudomotor and Sensory Nerve Testing in Painful Sensory Neuropathies James M. Killian, MD,* Shane Smyth, MD,* Rudy Guerra, PhD, Ishan Adhikari, MD,* and Yadollah Harati,
ORIGINAL CONTRIBUTION
ORIGINAL CONTRIBUTION Epidermal Nerve Fiber Density Normative Reference Range and Diagnostic Efficiency Justin C. McArthur, MBBS, MPH; E. Adelaine Stocks, MS; Peter Hauer, BS; David R. Cornblath, MD; John
Nerve fibre and sensory end organ density in the epidermis and papillary dermis of the human hand
British Journal of Plastic Surgery (2005) 58, 774 779 Nerve fibre and sensory end organ density in the epidermis and papillary dermis of the human hand E.J. Kelly a,b,c, G. Terenghi d, A. Hazari d, M.
Nerve Fiber Density Testing
Nerve Fiber Density Testing Policy Number: Original Effective Date: MM.02.020 11/01/2013 Line(s) of Business: Current Effective Date: HMO; PPO; QUEST Integration 12/16/2016 Section: Medicine Place(s) of
Epidermal Nerve Fiber Density
Let us help YOU make the diagnosis of small fiber peripheral neuropathy Epidermal Nerve Fiber Density Bako Integrated Physician Solutions is a pioneer in the development and use of epidermal nerve fiber
An Open-Label Study of the Lidocaine Patch 5% in Painful Idiopathic Sensory Polyneuropathy
Blackwell Science, LtdOxford, UKPMEPain Medicine1526-2375American Academy of Pain MedicineSeptember/October 20056 5379384Original ArticleLidocaine Patch 5%Herrmann et al. PAIN MEDICINE Volume 6 Number
Increased Density of Cutaneous Nerve Fibres in the Affected Dermatomes After Herpes Zoster Therapy
Acta Derm Venereol 2014; 94: 168 172 INVESTIGATIVE REPORT Increased Density of Cutaneous Nerve Fibres in the Affected Dermatomes After Herpes Zoster Therapy Charalampos Zografakis 1, Dina G. Tiniakos 2,
Nerve Fiber Density Measurement
Nerve Fiber Density Measurement Policy Number: 2.04.58 Last Review: 12/2018 Origination: 12/2015 Next Review: 12/2019 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will provide coverage for
Histopathological findings in primary erythromelalgia show a decrease in small nerve fiber density.
Histopathological findings in primary erythromelalgia show a decrease in small nerve fiber density. Mark D. P. Davis, MD,a Roger H. Weenig, MD,a Joseph Genebriera, MD,a Gwen Wendelschafer-Crabb, MS,c William
Research Article Clinical Utility of Skin Biopsy in Differentiating between Parkinson s Disease and Multiple System Atrophy
Parkinson s Disease Volume 2015, Article ID 167038, 7 pages http://dx.doi.org/10.1155/2015/167038 Research Article Clinical Utility of Skin Biopsy in Differentiating between Parkinson s Disease and Multiple
The time course of epidermal nerve bre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy
DOI: 10.1093/brain/awh175 Brain (2004), 127, 1606±1615 The time course of epidermal nerve bre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy Michael Polydefkis,
Skin biopsy in t of peripheral n
92 PRACTICAL NEUROLOGY REVIEW Skin biopsy in t of peripheral n Giuseppe Lauria Consultant Neurologist, Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Via Celoria,
Nerve Fiber Density Measurement
Nerve Fiber Density Measurement Policy Number: 2.04.58 Last Review: 12/2017 Origination: 12/2015 Next Review: 12/2018 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will provide coverage for
An Evaluation of Xylene-free Processing of Tissues From the Central Nervous System Using the PelorisTM Dual Retort Rapid Tissue Processor
An Evaluation of Xylene-free Processing of Tissues From the Central Nervous System Using the PelorisTM Dual Retort Rapid Tissue Processor Geoffrey Rolls Leica Microsystems, iosystems Division, Melbourne,
Histological Spectrum of Pure Neuritic Leprosy:
Department of Histopathology Postgraduate Institute of Medical Education & Research Chandigarh,India Histological Spectrum of Pure Neuritic Leprosy: Experience at Tertiary Care Centre Dr Uma Nahar INTRODUCTION
Number: Policy *Please see amendment for Pennsylvania Medicaid at the end of this CPB.
Number: 0774 Policy *Please see amendment for Pennsylvania Medicaid at the end of this CPB. Aetna considers measurement of intra epidermal nerve fiber density (IENFD) by skin biopsy medically necessary
Quantification of sweat gland innervation A clinical pathologic correlation
Quantification of sweat gland innervation A clinical pathologic correlation Christopher H. Gibbons, MD, MMSc Ben M.W. Illigens, MD Ningshan Wang, PhD Roy Freeman, MD Address correspondence and reprint
Compound Action Potential, CAP
Stimulus Strength UNIVERSITY OF JORDAN FACULTY OF MEDICINE DEPARTMENT OF PHYSIOLOGY & BIOCHEMISTRY INTRODUCTION TO NEUROPHYSIOLOGY Spring, 2013 Textbook of Medical Physiology by: Guyton & Hall, 12 th edition
Update on 2015 WHO Classification of Lung Adenocarcinoma 1/3/ Mayo Foundation for Medical Education and Research. All rights reserved.
1 Our speaker for this program is Dr. Anja Roden, an associate professor of Laboratory Medicine and Pathology at Mayo Clinic as well as consultant in the Anatomic Pathology Laboratory and co-director of
Functional sensory function recovery of random-pattern abdominal skin flap in the repair of fingertip skin defects
830 Functional sensory function recovery of random-pattern abdominal skin flap in the repair of fingertip skin defects YA-DONG YU, YING-ZE ZHANG, WEI-DONG BI and TAO WU Department of Hand Surgery, The
السكري للداء مرافقة فقاعات diabeticorum= Bullosis
1 / 6 Bullosis diabeticorum Bullous disease of diabetes (bullosis diabeticorum) is a distinct, spontaneous, noninflammatory, blistering condition of acral skin unique to patients with diabetes mellitus.
Effect of Propecia on the Hair Follicle in Male Androgenetic Alopecia: A Confocal Laser Scanning Microscopy and Video Imaging Study
Effect of Propecia on the Hair Follicle in Male Androgenetic Alopecia: A Confocal Laser Scanning Microscopy and Video Imaging Study Investigators: Department of Dermatology, University of Minnesota, Minneapolis,
doi: /j x
European Journal of Neurology 2010, 17: 903 912 EFNS/PNS GUIDELINES doi:10.1111/j.1468-1331.2010.03023.x European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin
Case report: Intraneural perineurioma of the sciatic nerve in an adolescent strategies for revealing the diagnosis
CASE REPORT Case report: Intraneural perineurioma of the sciatic nerve in an adolescent strategies for revealing the diagnosis Lars B. Dahlin 1, Inger Nennesmo 2, Jack Besjakov 3, Istvan Ferencz 4, Gert
Neuropathology of Skin Denervation in Acrylamide-Induced Neuropathy
Neurobiology of Disease 11, 155 165 (2002) doi:10.1006/nbdi.2002.0537 Neuropathology of Skin Denervation in Acrylamide-Induced Neuropathy Miau-Hwa Ko,*, Wen-Pin Chen,* and Sung-Tsang Hsieh*,,1 *Department
Clinical and Electrophysiological Abnormalities amongst the Patients of Diabetic Truncal Polyneuropathy
Original Article GCSMC J Med Sci Vol (VI) No (II) July-December 2017 Clinical and Electrophysiological Abnormalities amongst the Patients of Diabetic Truncal Polyneuropathy Chilvana Patel*, Surya Murthy
Pathology of Nerve Terminal Degeneration in the Skin
Journal of Neuropathology and Experimental Neurology Vol. 59, No. 4 Copyright 2000 by the American Association of Neuropathologists April, 2000 pp. 297 307 Pathology of Nerve Terminal Degeneration in the
CONSULTATION DURING SURGERY / NOT A FINAL DIAGNOSIS. FROZEN SECTION DIAGNOSIS: - A. High grade sarcoma. Wait for paraffin sections results.
Pathology Report Date: 3/5/02 A, B. Biopsy right distal femur- high grade spindle cell sarcoma Immunohistochemistry studies are pending to further classify the nature of the tumor. CONSULTATION DURING
Neuropathological alterations in diabetic truncal neuropathy: evaluation by skin biopsy
762 Institute of Neurology, University of Ferrara, Italy G Lauria Neurology P E Hauer J C McArthur JWGriYn D R Cornblath Epidemiology J C McArthur Neuroscience, Johns Hopkins University, Baltimore, MD,
Guideline. Associated Documents ASCO CAP 2018 GUIDELINES and SUPPLEMENTS -
Guideline Subject: ASCO CAP 2018 HER2 Testing for Breast Cancer Guidelines - Recommendations for Practice in Australasia Approval Date: December 2018 Review Date: December 2022 Review By: HER2 testing
Diabetic Neuropathy. Nicholas J. Silvestri, M.D.
Diabetic Neuropathy Nicholas J. Silvestri, M.D. Types of Neuropathies Associated with Diabetes Mellitus p Chronic distal sensorimotor polyneuropathy p Focal compression neuropathies p Autonomic neuropathy
Training Issues for the Future of Muscle Pathology in the USA. Elizabeth Cochran, M.D. and Suzanne Powell, M.D.
Training Issues for the Future of Muscle Pathology in the USA Elizabeth Cochran, M.D. and Suzanne Powell, M.D. Training in Neuromuscular Pathology Suzanne Powell, M.D. Training in muscle, nerve and eye
Preparation and Analysis of the Peripheral Nervous System
Toxicologic Pathology, 39: 66-72, 2011 Copyright # 2011 by The Author(s) ISSN: 0192-6233 print / 1533-1601 online DOI: 10.1177/0192623310387618 Preparation and Analysis of the Peripheral Nervous System
Motor and sensory nerve conduction studies
3 rd Congress of the European Academy of Neurology Amsterdam, The Netherlands, June 24 27, 2017 Hands-on Course 2 Assessment of peripheral nerves function and structure in suspected peripheral neuropathies
Symptomatic pain treatments (carbamazepine and gabapentin) were tried and had only a transient and incomplete effect on the severe pain syndrome.
Laurencin 1 Appendix e-1 Supplementary Material: Clinical observations Patient 1 (48-year-old man) This patient, who was without a notable medical history, presented with thoracic pain and cough, which
Vascular Cognitive Impairment-- NEUROPATHOLOGIC ISSUES. VCI vs. IVD/DEMENTIA with VASCULAR DISEASE (IVD) advanced pathology
Vascular Cognitive Impairment-- NEUROPATHOLOGIC ISSUES VCI vs. IVD/DEMENTIA with VASCULAR DISEASE (IVD) advanced pathology HANDLING the BRAIN at AUTOPSY: What to FIX vs. what to FREEZE? --no need to be
Review Article Should Skin Biopsies Be Performed in Patients Suspected of Having Parkinson s Disease?
Hindawi Parkinson s Disease Volume 2017, Article ID 6064974, 6 pages https://doi.org/10.1155/2017/6064974 Review Article Should Skin Biopsies Be Performed in Patients Suspected of Having Parkinson s Disease?
Supplementary Figure 1 The ability to regenerate an ear hole is discontinuous with wound healing. Ear-hole closure at D85 for each sex within each
Supplementary Figure 1 The ability to regenerate an ear hole is discontinuous with wound healing. Ear-hole closure at D85 for each sex within each species observed. Data show a binary response to a 4 mm
Peripheral neuropathy is a common
Pathophysiology/Complications O R I G I N A L A R T I C L E The Relationship Among Pain, Sensory Loss, and Small Nerve Fibers in Diabetes LEA SORENSEN, RN, BHSC 1,2 LYNDA MOLYNEAUX, RN 1 DENNIS K. YUE,
The Neuropad test: a visual indicator test for human diabetic neuropathy
Diabetologia (2008) 51:1046 1050 DOI 10.1007/s00125-008-0987-y ARTICLE The Neuropad test: a visual indicator test for human diabetic neuropathy C. Quattrini & M. Jeziorska & M. Tavakoli & P. Begum & A.
Index. Note: Page numbers of article titles are in boldface type.
Neurol Clin N Am 20 (2002) 605 617 Index Note: Page numbers of article titles are in boldface type. A ALS. See Amyotrophic lateral sclerosis (ALS) Amyotrophic lateral sclerosis (ALS) active denervation
Lecture VIII. The Spinal Cord, Reflexes and Brain Pathways!
Reflexes and Brain Bio 3411! Monday!! 1! Readings! NEUROSCIENCE 5 th ed: Review Chapter 1 pp. 11-21;!!Read Chapter 9 pp. 189-194, 198! THE BRAIN ATLAS 3 rd ed:! Read pp. 4-17 on class web site! Look at
Repair of Stump Neuroma Using AxoGuard Nerve Protector and Avance Nerve Graft in the Lower Extremity
Repair of Stump Neuroma Using AxoGuard Nerve Protector and Avance Nerve Graft in the Lower Extremity Edgardo R. Rodriguez Collazo, DPM Jeffrey Weiland, DPM Department of Surgery Presence Health Saint Joseph
Fine Structure of the Normal Trigeminal Ganglion in the Cat and Monkey*
Fine Structure of the Normal Trigeminal Ganglion in the Cat and Monkey* DAVID S. MAXWELL, PH.D. Principal Contributor and Leader of Discussion HE inclusion of animal material m a y be justified as a means
Guide to the use of nerve conduction studies (NCS) & electromyography (EMG) for non-neurologists
Guide to the use of nerve conduction studies (NCS) & electromyography (EMG) for non-neurologists What is NCS/EMG? NCS examines the conduction properties of sensory and motor peripheral nerves. For both
Somatosensory System. Steven McLoon Department of Neuroscience University of Minnesota
Somatosensory System Steven McLoon Department of Neuroscience University of Minnesota 1 Course News Dr. Riedl s review session this week: Tuesday (Oct 10) 4-5pm in MCB 3-146B 2 Sensory Systems Sensory
Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy
Review Pathophysiology http://dx.doi.org/10.4093/dmj.2015.39.6.461 pissn 2233-6079 eissn 2233-6087 DIABETES & METABOLISM JOURNAL Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy
Cutaneous Structural and Biochemical Correlates of Foot Complications in High-Risk Diabetes
Pathophysiology/Complications O R I G I N A L A R T I C L E Cutaneous Structural and Biochemical Correlates of Foot Complications in High-Risk Diabetes ABD A. TAHRANI, MD 1,2 WEI ZENG, PHD 1 JAYADAVE SHAKHER,
Final Scientific Progress Report
CUREPSP Final Scientific Progress Report Tau in Peripheral Tissues of PSP and CBD. Brittany Dugger, PhD; University of California San Francisco Specific Aim: Using immunohistochemical methods on autopsy
Peripheral neuropathy has been reported
JOEM Volume 48, Number 6, June 2006 549 CME Available for this Article at ACOEM.org Reduced Epidermal Nerve Density Among Hand-Transmitted Vibration-Exposed Workers Huey-Wen Liang, MD, MSc Sung-Tsang Hsieh,
Bi/CNS/NB 150: Neuroscience. November 11, 2015 SOMATOSENSORY SYSTEM. Ralph Adolphs
Bi/CNS/NB 150: Neuroscience November 11, 2015 SOMATOSENSORY SYSTEM Ralph Adolphs 1 Menu for today Touch -peripheral -central -plasticity Pain 2 Sherrington (1948): senses classified as --teloreceptive
NERVOUS SYSTEM ANATOMY
INTRODUCTION to NERVOUS SYSTEM ANATOMY M1 - Gross and Developmental Anatomy Dr. Milton M. Sholley Professor of Anatomy and Neurobiology and Dr. Michael H. Peters Professor of Chemical and Life Science
TREATMENT WITH ORAL METAFOL L APPEARS TO PROMOTE RESTORATION OF LOST CUTANEOUS SENSATION IN DIABETIC PERIPHERAL NEUROPATHY
IJPSR (2017), Volume 8, Issue 7 (Research Article) Received on 14 December, 2016; received in revised form, 09 February, 2017; accepted, 17 February, 2017; published 01 July, 2017 TREATMENT WITH ORAL METAFOL
NERVOUS SYSTEM ANATOMY
NTRODUCTON to NERVOUS SYSTEM ANATOMY M1 - Gross and Developmental Anatomy Dr. Milton M. Sholley Professor of Anatomy and Neurobiology and Dr. Michael H. Peters Professor of Chemical and Life Science Engineering
Carcinoma of the Renal Pelvis and Ureter Histopathology
Carcinoma of the Renal Pelvis and Ureter Histopathology Reporting Proforma (NEPHROURETERECTOMY AND URETERECTOMY) Includes the International Collaboration on Cancer reporting dataset denoted by * Family
Skin biopsy. Sophia Otto SA Pathology
Skin biopsy Sophia Otto SA Pathology RCPA (Royal College of Pathologists of Australasia) The RCPA is the leading organisation representing pathologists in Australasia. Its mission is to train and support
Skin Biopsy Findings in Patients With CMT1A: Baseline Data From the CLN-PXT Study Provide New Insights Into the Pathophysiology of the Disorder
J Neuropathol Exp Neurol Vol., No., 218, pp. 1 8 doi: 1.193/jnen/nly1 ORIGINL RTICLE Skin iopsy Findings in Patients With CMT1: aseline Data From the CLN-PXT33-1 Study Provide New Insights Into the Pathophysiology
Disclosure. Entrapment Neuropathies - Overview. Common mononeuropathy sites. Definitions. Common mononeuropathy sites. Common mononeuropathy sites
Disclosure Entrapment Neuropathies - Overview I receive compensation from Wiley- Blackwell publishers for my work as Editor-in-Chief of Muscle & Nerve Lawrence H. Phillips, II, MD Definitions Mononeuropathy:
Morphometric Analysis of the Human Trigeminal Nerve
Okajimas Folia Anat. Jpn., 78(2-3): 49-54, August. 2001 Morphometric Analysis of the Human Trigeminal Nerve By Hiromitsu EZURE, Noboru GOTO, Naoko NONAKA, Jun GOTO and Hiroaki TANI Department of Anatomy,
ELASTIC GLOBES IN HUMAN SKIN* HERMANN PINKUS, MD., AMIR H. MEHREGAN, MD. AND RENATO G. STARICCO, MD.
THE JOURNAL OF NVESTOATVE DERMATOLOGY Copyright 1565 by The Williams & Wilkins Co. Vol. 45, No. 2 Printed in U.S.A. ELASTC GLOBES N HUMAN SKN* HERMANN PNKUS, MD., AMR H. MEHREGAN, MD. AND RENATO G. STARCCO,
Pinni Meedha Mojutho Ammanu Dengina Koduku Part 1 Kama Kathalu
Search for: Search Search Cpt code for punch biopsy of skin Pinni Meedha Mojutho Ammanu Dengina Koduku Part 1 Kama Kathalu Code this! Answers: CPT curetting, and using a skin punch. Biopsy codes are arranged
Microscopic study of the normal skin in cases of mycosis fungoides
Microscopic study of the normal skin in cases of mycosis fungoides M. El Darouti, S. Marzook, M. Bosseila, O. Abu Zeid, O. El- Safouri, A. Zayed, A. El-Ramly Egyptian Dermatology Online Journal 2 (1):
Nerve pathologic features differentiate POEMS syndrome from CIDP
Piccione et al. Acta Neuropathologica Communications (2016) 4:116 DOI 10.1186/s40478-016-0389-1 RESEARCH Nerve pathologic features differentiate POEMS syndrome from CIDP Ezequiel A. Piccione 1, Janean
Sheet Preparations Expose the Dermal Nerve Plexus of Human Skin and Render the Dermal Nerve End Organ Accessible to Extensive Analysis
Sheet Preparations Expose the Dermal Nerve Plexus of Human Skin and Render the Dermal Nerve End Organ Accessible to Extensive Analysis Erwin Tschachler, w 1 Christina M. Reinisch, 1 Christoph Mayer, Karin
Clinical Aspects of Peripheral Nerve and Muscle Disease. Roy Weller Clinical Neurosciences University of Southampton School of Medicine
Clinical Aspects of Peripheral Nerve and Muscle Disease Roy Weller Clinical Neurosciences University of Southampton School of Medicine Normal Nerves 1. Anterior Horn Cell 2. Dorsal root ganglion cell 3.
Kim Chong Hwa MD,PhD Sejong general hospital, Division of endocrine & metabolism
Kim Chong Hwa MD,PhD Sejong general hospital, Division of endocrine & metabolism st1 Classification and definition of diabetic neuropathies Painful diabetic peripheral neuropathy Diabetic autonomic neuropathy
Aortic depressor nerve unmyelinated fibers in spontaneously hypertensive rats
Am J Physiol Heart Circ Physiol 280: H1560 H1564, 2001. Aortic depressor nerve unmyelinated fibers in spontaneously hypertensive rats VALÉRIA PAULA SASSOLI FAZAN, 1 HELIO CESAR SALGADO, 2 AND AMILTON ANTUNES
Clinical Policy Bulletin: Nerve Fiber Density Measurement
Nerve Fiber Density Measurement Page 1 of 15 Clinical Policy Bulletin: Nerve Fiber Density Measurement Number: 0774 Policy Aetna considers measurement of intra-epidermal nerve fiber density (IENFD) by
A Human Model of Small Fiber Neuropathy to Study Wound Healing
A Human Model of Small Fiber Neuropathy to Study Wound Healing The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation Published
Skin biopsy: an emerging method for small nerve fiber evaluation
ANNALS OF CLINICAL NEUROPHYSIOLOGY REVIEW Ann Clin Neurophysiol 2018;20(1):3-11 Skin biopsy: an emerging method for small nerve fiber evaluation Eun Hee Sohn Department of Neurology, Chungnam National
Pathological changes in the vagus nerve in diabetes
Journal of Neurology, Neurosurgery, and Psychiatry 1987;50:1449-1453 Pathological changes in the vagus nerve in diabetes and chronic alcoholism Y-P GUO,* J G McLEOD, J BAVERSTOCK From the Department of
Histopathology of experimental ethambutol intoxication. SIMMONS LESSELL.
Reports- 765 Histopathology of experimental ethambutol intoxication. SIMMONS LESSELL. Ethambutol was administered to albino rats in their drinking water in doses of 105 to 2,500 mg. per kilogram per day
DIAGNOSIS OF DIABETIC NEUROPATHY
DIAGNOSIS OF DIABETIC NEUROPATHY Dept of PM&R, College of Medicine, Korea University Dong Hwee Kim Electrodiagnosis ANS Clinical Measures QST DIAGRAM OF CASUAL PATHWAYS TO FOOT ULCERATION Rathur & Boulton.
Retrospective 10 years review of 100 patients with psoriasis in the Kingdom of Saudi Arabia (KSA)
Retrospective 10 years review of 100 patients with psoriasis in the Kingdom of Saudi Arabia (KSA) Ahmed Abdullah Alhumidi King saud university, Riyadh, kingdom of Saudi Arabia Abstract Background: This
Kidney Case 1 SURGICAL PATHOLOGY REPORT
Kidney Case 1 Surgical Pathology Report February 9, 2007 Clinical History: This 45 year old woman was found to have a left renal mass. CT urography with reconstruction revealed a 2 cm medial mass which
Comparison of Somatic and Sudomotor Nerve Fibers in Type 2 Diabetes Mellitus
JCN Open Access pissn 1738-6586 / eissn 2005-5013 / J Clin Neurol 2017;13(4):366-370 / https://doi.org/10.3988/jcn.2017.13.4.366 ORIGINAL ARTICLE Comparison of Somatic and Sudomotor Nerve Fibers in Type
Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments
DOI: 10.1093/brain/awh180 Brain (2004), 127, 1593±1605 Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments Chia-Tung Shun, 1,4 Yang-Chyuan Chang, 2 Huey-Peir
Shalini Mahajan, M.D. Director, LA Neuromuscular Center (LANMC) Attune Health, Beverly Hills, CA
Shalini Mahajan, M.D. Director, LA Neuromuscular Center (LANMC) Attune Health, Beverly Hills, CA Business Address LA Neuromuscular Center Attune Health 8750 Wilshire Blvd, Ste 350, Beverly Hills, CA 90211
1/30/2019. Disclosures. Learning Objectives. An Approach to Small Fiber Neuropathies
An Approach to Small Fiber Neuropathies Disclosures A. Gordon Smith, MD C. Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research (Neurology) Professor and Chair of Neurology
Pain. Pain. Pain: One definition. Pain: One definition. Pain: One definition. Pain: One definition. Psyc 2906: Sensation--Introduction 9/27/2006
Pain Pain Pain: One Definition Classic Paths A new Theory Pain and Drugs According to the international Association for the Study (Merskey & Bogduk, 1994), Pain is an unpleasant sensory and emotional experience