Research in IBD at University of Colorado Denver
|
|
- Jessica Russell
- 5 years ago
- Views:
Transcription
1 Research in IBD at University of Colorado Denver Blair Fennimore, MD Assistant Professor of Medicine Division of Gastroenterology and Hepatology UCH Crohn s and Colitis Center Mucosal Inflammation Program
2 Epidemiology of PSC-IBD ~1.4 million with IBD in the US ~5% of UC with PSC Up to 90% of PSC with UC >50,000 with IBD in the Mountain West >12,000 along the front range Gastro 2004:126; NEJM 1995:332;
3 Major Regional IBD Centers Rochester, MN Chicago Denver Los Angeles
4 IBD Research Model at UCH Three highly collaborative clinical and basic science research arms Crohn s and Colitis Center Children s Hospital Colorado Pediatric Inflammatory Bowel Disease Center
5 4 P s Physical Proximity Promotes Partnership Mucosal Inflammation Program University of Colorado Hospital Crohn s & Colitis Center Children s Hospital Colorado Pediatric Inflammatory Bowel Disease Center Anschutz Medical Campus Aurora, Colorado
6 A multi-disciplinary center of excellence committed to the identification of novel targets for diagnosis and directed therapy of mucosal disease.
7
8 Cumulative Funding Funding, ($Direct + F&A), million million Mucosal Inflammation Program 2007 n= n=49 5 labs 7 specialties Private Donations Foundations 10% 7% 10% Other 7% Fiscal Year NIH 80% 80%
9 Inflammatory Bowel Disease Pathogenesis ~150 genes Complex heredity Genetics Immune System Cytokine Imbalance Immune Medications IBD Environment Gut Bacteria
10 Immunity of IBD Meta-analysis of GWAS (CD 2010, UC 2011) ~150 SNP s 99 total disease loci 28 shared loci >85% of IBD genes relate to Innate Immunity Nature 2011:474;307
11 Ongoing Work in Innate Immunity Autophagy Neutrophil Trafficking Angiogenesis Shifts in the Microbiome Nucleotide Metabolism Oxygen Metabolism
12 Hypoxia in IBD Hypoxia = Low Oxygen Normal Colitis
13 Hypoxia Inducible Factor - HIF α β + = α β HIF Normoxia Hypoxia O 2 O 2 α O 2 α HO α α Hypoxia α HO α α + β α β Gene Transcription DNA
14 HIF in Mouse Models of Colitis HIF Knockout Mice DSS Colitis Body weight Barrier Healthy Mice Control Colitis Mutant Colitis + - Colitis
15 Plasma EPO (miu/ml) % Initial Bodyweight TNF mrna (Fold-Increase) HIF in Mouse Models of Colitis FG4497 Treatment HIF Stabilizer ( HIF levels) Oral delivery benefit Decreases tissue TNF O 2 O 2 O 2 α βα α IV PO * * 4 3 * * * Vehicle FG4497 Ctl Veh FG-4497 (mg/kg) 0 Ctl Veh FG-4497 (mg/kg) Gastroenterology 134: , 2008
16 HIF in Mouse Models of Colitis Healthy Colitis Colitis + FG4497 Gastroenterology 134: , 2008 HIF is protective at many levels in colitis FG4497 (HIF mimetic) is a strong therapeutic option for oral delivery FG4592 in Phase III Clinical Trials for Anemia
17 Creatine Metabolism P ATP ADP Creatine Creatine Kinase P Phospho Creatine P ATP
18 Creatine as a Biomarker in Colitis Creatine Concentration TNBS Colitis Healthy Colitis Creatine Phospho Creatine PCr/Cr Ratio
19 Decreased Levels of CK in Human IBD Creatine Kinase Levels in IBD CK Staining in IBD Normal Normal Crohn s UC Abnormal Creatine/Phospho- Creatine Pathway in IBD Ulcerative Colitis PNAS 2013:110;
20 Creatine Supplements in Colitis Healthy Colitis Colitis + 2% Cr Creatine supplementation improved colitis severity in a mouse model
21 UCH Crohn s and Colitis Center Crohn s and Colitis Center
22 UCH Crohn s and Colitis Center
23 Clinical Research in IBD at UCH RESEARCH IBD Database Umbrella protocol Disease Phenotype Disease Activity Measures Biorepository: > 500 patients Serum Tissue Clinical Trials: CCFA Clinical Research Alliance - MERIT-UC - PUCCINI Industry-Sponsored studies - Placental Stem Cell infusions Investigator-Initiated studies - Creatine supplementation IBD Clinic POPULATION MGMT Evidence-Based Care QI Initiatives Performance Measurement - PQRS: AGA BTE Program
24 Clinical Research Trials MERIT-UC NIH funded study using Methotrexate in UC PUCCINI Study to clarify the risks associated with the use of IBD medications at the time of surgery Placental Stem Cell Infusion Study of placental stem cell infusions as adjunct therapy in severe/refractory Crohn s disease Creatine Supplementation in UC Study of Creatine supplementation in treatment of mild-moderate UC
25 IBD Research at UCH Exciting ongoing research through the MIP and UCH Crohn s and Colitis Center Basic science Translational research Clinical trials in new IBD therapies Quality improvement initiatives in patient care Multidisciplinary approach to clinical IBD care
26 Thank You
Understanding clinical aspects of Crohn s disease and ulcerative colitis: Implications for the basic scientist
Understanding clinical aspects of Crohn s disease and ulcerative colitis: Implications for the basic scientist Scott Plevy, MD Associate Professor of Medicine, Microbiology & Immunology UNC School of Medicine
More informationInnate immune regulation of T-helper (Th) cell homeostasis in the intestine
Innate immune regulation of T-helper (Th) cell homeostasis in the intestine Masayuki Fukata, MD, Ph.D. Research Scientist II Division of Gastroenterology, Department of Medicine, F. Widjaja Foundation,
More informationGenetic and Environmental Risks for IBD
Genetic and Environmental Risks for IBD CCFA April 26, 2014 Presented by: Name goes here April 30, 2014 TheoTheodore 1 Genetic and Environmental Risks for IBD Theodore M. Bayless, M.D. Director Emeritus
More informationGenetics of Pediatric Inflammatory Bowel Disease
Genetics of Pediatric Inflammatory Bowel Disease Judith Kelsen MD Assistant Professor of Pediatrics Division of Gastroenterology, Hepatology, and Nutrition IBD Education Day 2/9/2014 Objectives Brief overview
More informationGalapagos Mechelen, Belgium, and Romainville, France. Digestive Disease Week 2014 pres# 188 Saturday, May 3
Exploration of GLPG0634, the first selective JAK1 inhibitor, in Inflammatory Bowel Disease is supported by early clinical results and mouse DSS-colitis data René Galien, Didier Merciris, Frédéric Vanhoutte,
More informationThe enteric microbiota: Implications for IBD. Eugene B. Chang, M.D. University of Chicago
The enteric microbiota: Implications for IBD Eugene B. Chang, M.D. University of Chicago On a per cell basis, humans are mostly prokaryote 100 90 80 70 60 50 40 30 20 10 0 EuK ProK The microbial flora
More informationRecent Advances in the Management of Refractory IBD
Recent Advances in the Management of Refractory IBD Raina Shivashankar, M.D. Assistant Professor of Medicine Division of Gastroenterology and Hepatology Thomas Jefferson University Philadelphia, PA Outline
More informationIBD 101. Ronen Stein, MD Assistant Professor of Clinical Pediatrics Division of Gastroenterology, Hepatology, and Nutrition
IBD 101 Ronen Stein, MD Assistant Professor of Clinical Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Objectives Identify factors involved in the development of inflammatory bowel
More informationFaecalibacterium prausnitzii
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients PNAS 105(43): 16731-16736, 2008. Speaker: Ming-Cheng Chen Advisor:
More informationINFLAMMATORY BOWEL DISEASE. Jean-Paul Achkar, MD Center for Inflammatory Bowel Disease Cleveland Clinic
INFLAMMATORY BOWEL DISEASE Jean-Paul Achkar, MD Center for Inflammatory Bowel Disease Cleveland Clinic WHAT IS INFLAMMATORY BOWEL DISEASE (IBD)? Chronic inflammation of the intestinal tract Two related
More informationSupplemental Table 1. Primers used for RT-PCR analysis of inflammatory cytokines Gene Primer Sequence
Supplemental Table 1. Primers used for RT-PCR analysis of inflammatory cytokines Gene Primer Sequence IL-1α Forward primer 5 -CAAGATGGCCAAAGTTCGTGAC-3' Reverse primer 5 -GTCTCATGAAGTGAGCCATAGC-3 IL-1β
More informationPEDIATRIC INFLAMMATORY BOWEL DISEASE
PEDIATRIC INFLAMMATORY BOWEL DISEASE Alexis Rodriguez, MD Pediatric Gastroenterology Advocate Children s Hospital Disclosers Abbott Nutrition - Speaker Inflammatory Bowel Disease Chronic inflammatory disease
More informationResearch Update: Looking for the Answers
Research Update: Looking for the Answers Ted Denson, M.D. Schubert-Martin Inflammatory Bowel Disease Center Research Support: NIH/NIDDK, CCFA, BMRP Figure 2 Approach to Improve Outcomes for our IBD Patients
More informationHLA TYPING AND EXPRESSION: POTENTIAL MARKER FOR IDENTIFYING EARLY DYSPLASIA AND STRATIFYING THE RISK FOR IBD-CANCER
HLA TYPING AND EXPRESSION: POTENTIAL MARKER FOR IDENTIFYING EARLY DYSPLASIA AND STRATIFYING THE RISK FOR IBD-CANCER Megan Garrity, S. Breanndan Moore, M.D., William Sandborn, M.D., Vernon Pankratz, Ph.D.,
More informationIBD 101. Ronen Stein, MD Assistant Professor of Clinical Pediatrics Division of Gastroenterology, Hepatology, and Nutrition
IBD 101 Ronen Stein, MD Assistant Professor of Clinical Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Objectives Identify factors involved in the development of inflammatory bowel
More informationPersonalized Medicine. Selecting the Right First-line Biologic Agent. Gene Expression Profiles Crohn s Disease. The Right Treatment
Personalized Medicine Selecting the Right First-line Biologic Agent William Tremaine, M.D. Maxine and Jack Zarrow Professor Mayo Clinic Rochester, MN, USA The Right Treatment Pretreatment Genomic Analysis
More informationTolerance 2. Regulatory T cells; why tolerance fails. Abul K. Abbas UCSF. FOCiS
1 Tolerance 2. Regulatory T cells; why tolerance fails Abul K. Abbas UCSF FOCiS 2 Lecture outline Regulatory T cells: functions and clinical relevance Pathogenesis of autoimmunity: why selftolerance fails
More informationTreatment of Pediatric IBD: What is Different?
Treatment of Pediatric IBD: What is Different? January 13, 2017 Michael Kappelman MD, MPH University of North Carolina at Chapel Hill Overview Is Pediatric IBD the same disease? Treatment considerations
More informationGenetics. Environment. You Are Only 10% Human. Pathogenesis of IBD. Advances in the Pathogenesis of IBD: Genetics Leads to Function IBD
Advances in the Pathogenesis of IBD: Genetics Leads to Function Pathogenesis of IBD Environmental Factors Microbes Scott Plevy, MD Associate Professor of Medicine, Microbiology & Immunology UNC School
More informationGut Microbiota and IBD. Vahedi. H M.D Associate Professor of Medicine DDRI
Gut Microbiota and IBD Vahedi. H M.D Associate Professor of Medicine DDRI 1393.3.1 2 GUT MICROBIOTA 100 Trillion Microbes - 10 times more than cells in our body Collective weight of about 1kg in human
More informationIL-12 family members in experimental colitis. Markus F. Neurath I. Medical Clinic Johannes Gutenberg-University Mainz, Germany
IL-12 family members in experimental colitis Markus F. Neurath I. Medical Clinic Johannes Gutenberg-University Mainz, Germany IBD - Pathogenesis Genetic Predisposition Bacterial Antigens Activation of
More information10/11/2010. Jonathan Braun, MD, PhD David Geffen School of Medicine at UCLA CCFA National Scientific Advisory Committee
Jonathan Braun, MD, PhD David Geffen School of Medicine at UCLA CCFA National Scientific Advisory Committee 1 Crohn s Disease Chronic disease of the intestines Sores (ulceration), perforation, scaring,
More informationAli Keshavarzian MD Rush University Medical Center, Chicago, IL
Ali Keshavarzian MD Rush University Medical Center, Chicago, IL Ulcerative colitis Crohn s disease Optimize Quality of Life Induce remission [treat flare up] Maintain remission [avoid flare up] Prevent
More informationMedical Therapy for Pediatric IBD: Efficacy and Safety
Medical Therapy for Pediatric IBD: Efficacy and Safety Betsy Maxwell, MD Assistant Professor of Clinical Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Pediatric IBD: Defining Remission
More informationInnate immunity as a therapeutic target in IBD. Elke Cario Division of Gastroenterology & Hepatology University Hospital of Essen Essen, Germany
Innate immunity as a therapeutic target in IBD Elke Cario Division of Gastroenterology & Hepatology University Hospital of Essen Essen, Germany The intestinal mucosa must rapidly recognize luminal pathogens
More informationSignal Transduction in Inflammatory Bowel Disease
E v e n t s 0 6 4 Signal Transduction in Inflammatory Bowel Disease 0 1 2 3 4 1 0 1 0 1 0 1 0 1 0 F L 2 - H e ig h t Vineeta Khare Ph.D Overview Inflammatory Bowel Diseases 1. Epidemiology, Symptoms and
More informationEfficacy and Safety of Treatment for Pediatric IBD
Efficacy and Safety of Treatment for Pediatric IBD Andrew B. Grossman MD Co-Director, Center for Pediatric Inflammatory Bowel Disease Associate Professor of Clinical Pediatrics Division of Gastroenterology,
More informationTestimony Submitted by: Eric Zuckerman, DO Bloomfield Hill, MI Board Chairman, Pediatric IBD Foundation
Testimony Submitted by: Carlo Di Lorenzo, MD Nationwide Children s Hospital, Columbus, OH President, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Benjamin Gold, MD, Children's
More informationTolerance 2. Regulatory T cells; why tolerance fails. FOCiS. Lecture outline. Regulatory T cells. Regulatory T cells: functions and clinical relevance
1 Tolerance 2. Regulatory T cells; why tolerance fails Abul K. Abbas UCSF FOCiS 2 Lecture outline Regulatory T cells: functions and clinical relevance Pathogenesis of autoimmunity: why selftolerance fails
More informationDIVISION OF GASTROENTEROLOGY
DR. Lloyd Mayer T H E H E N R Y D. J A N O W I T Z DIVISION OF GASTROENTEROLOGY Mount Sinai is consistently ranked among the top five gastroenterology centers in the nation. The irresistible combination
More informationNature Immunology: doi: /ni Supplementary Figure 1
Supplementary Figure 1 NLRP12 is downregulated in biopsy samples from patients with active ulcerative colitis (UC). (a-g) NLRP12 expression in 7 UC mrna profiling studies deposited in NCBI GEO database.
More informationWhat Have We Learned About the Microbiome in Pediatric IBD?
What Have We Learned About the Microbiome in Pediatric IBD? Ted Denson, MD Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine Disclosures: NIH, CCF, AbbVie
More informationJAK-STAT Signaling and Disease Pathogenesis in RA and IBD
Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including
More informationNew Insights on the Structure of the Human Gut Microbiota. Chaysavanh Manichanh, PhD Vall d Hebron Research Institute Barcelona
New Insights on the Structure of the Human Gut Microbiota Chaysavanh Manichanh, PhD Vall d Hebron Research Institute Barcelona Sessio Societat Catalana Malalties Infecciosas i Microbiologia March 20th,
More informationTo help protect your privacy, PowerPoint prevented this external picture from being automatically downloaded. To download and display this picture,
To help protect your privacy, PowerPoint prevented this external picture from being automatically downloaded. To download and display this picture, click Options in the Message Bar, and then click Enable
More informationCaffeine Modulates Hyperoxia - Induced Angiogenesis in Newborn Mice
Caffeine Modulates Hyperoxia - Induced Angiogenesis in Newborn Mice Vikramaditya Dumpa, MD Lori C Nielsen, MS Huamei Wang, MD Vasanth HS Kumar, MD Supported by AAP Marshall Klaus Perinatal Research Grant
More informationIs there an anti-inflammatory diet in IBD?
CCFA North Texas Chapter IBD education symposium December 2, 2017, Dallas, TX Is there an anti-inflammatory diet in IBD? Themos Dassopoulos, MD Director, Baylor Scott and White Center for IBD Baylor University
More informationThe role of Surgery and Stomas in IBD
The role of Surgery and Stomas in IBD When do I need it? Can I avoid it? How do I live with it? Kyle G. Cologne, MD Assistant Professor of Surgery USC Division of Colorectal Surgery Topics Surgical Differences
More informationBUT ONLY MINIMALLY AFFECTS OTHER INDICATORS OF COLONIC INTEGRITY IN A RAT MODEL OF
EMU OIL INCREASES CRYPT DEPTH BUT ONLY MINIMALLY AFFECTS OTHER INDICATORS OF COLONIC INTEGRITY IN A RAT MODEL OF COLITIS SUZANNE MASHTOUB Discipline of Physiology, School of Molecular & Biomedical Science,
More informationNOD2 Activation promotes anti-inflammatory activity of human Umbilical cord blood MSCs against Inflammatory bowel disease
NOD2 Activation promotes anti-inflammatory activity of human Umbilical cord blood MSCs against Inflammatory bowel disease Prof. Kyung-Sun Kang, DVM, PhD. Adult Stem Cell Research Center Seoul National
More informationWhat is IBD and Why Me?
Johns Hopkins Symposium: An Integrative Medicine Approach to Inflammatory Bowel Disease (IBD) What is IBD and Why Me? Steven R. Brant, M.D. Associate Professor of Medicine Director, Meyerhoff Inflammatory
More informationEntrustable Professional Activity
Entrustable Professional Activity 1. EPA Title: Care of infants, children and adolescents with inflammatory bowel disease 2. Description of Activity Practicing subspecialists must be trained to care for
More informationInflammatory Bowel Diseases (IBD) Clinical aspects Nitsan Maharshak M.D., IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Soura
Inflammatory Bowel Diseases (IBD) Clinical aspects Nitsan Maharshak M.D., IBD Center, Department of Gastroenterology and Liver Diseases Tel Aviv Sourasky Medical Center Tel Aviv, Israel IBD- clinical features
More informationChronic Granulomatous Disease Managing GI Issues
Chronic Granulomatous Disease Managing GI Issues N I C H O L A S H A R T O G, M D D i r e c t o r o f P e d i a t r i c / A d u l t P r i m a r y I m m u n o d e f i c i e n c y C l i n i c A s s i s t
More informationNutritional Requirements for Inflammatory Bowel Disease. Dale Lee, MD, MSCE Assistant Professor of Pediatrics University of Washington
Nutritional Requirements for Inflammatory Bowel Disease Dale Lee, MD, MSCE Assistant Professor of Pediatrics University of Washington No disclosures Objectives 1) Review the biological mechanisms disturbed
More informationImproving outcome of Inflammatory Bowel Disease in children
Improving outcome of Inflammatory Bowel Disease in children Dinesh Pashankar, MD Pediatric Gastroenterologist Director- Pediatric IBD program Yale University School of Medicine Pediatric Gastroenterology
More informationIssues at Hand. Inflammatory Bowel Disease Paradigm. Diet changes the fecal microbiome. Experience with diet in IBD
Diet s Role in IBD David Suskind M.D. Professor of Pediatrics Director of Clinical Gastroenterology Division of Gastroenterology University of Washington Seattle Children s Hospital Issues at Hand Inflammatory
More informationJonathan Braun, MD, PhD David Geffen School of Medicine at UCLA CCFA National Scientific Advisory Committee
Jonathan Braun, MD, PhD David Geffen School of Medicine at UCLA CCFA National Scientific Advisory Committee 1 Program Objectives Provide an overview of Crohn s disease Highlight newly uncovered genes and
More informationMurine Models of. Inflammatory Bowel Disease. Outline. Laura P. Hale, M.D. Ph.D. Professor of Pathology Duke University Medical Center
Murine Models of Inflammatory Bowel Disease Laura P. Hale, M.D. Ph.D. Professor of Pathology Duke University Medical Center September 19, 2017 Outline Review of IBD in humans Murine models of IBD Tissue
More informationStepping in for Patients with Inflammatory Bowel Disease
21 APRIL THURSDAY Dinner Meeting: 6:00 8:00 PM Moscone West Convention Center, Room 3014-3016 San Francisco, CA Stepping in for Patients with Inflammatory Bowel Disease Held in conjunction with the AMCP
More informationNOVEL BIOMARKERS AS RISK FACTORS FOR CARDIOVASCULAR DISEASE
NOVEL BIOMARKERS AS RISK FACTORS FOR CARDIOVASCULAR DISEASE Amy Alman, PhD Assistant Professor of Epidemiology College of Public Health University of South Florida Causation is a concept central to epidemiology
More informationGut Microbes: Potential targets in the prevention and treatment of IBD. Neelendu Dey, MD Instructor Division of Gastroenterology
Gut Microbes: Potential targets in the prevention and treatment of IBD Neelendu Dey, MD Instructor Division of Gastroenterology Disclosure The following are my disclosures. Potential conflicts of interest
More informationPage 1. Is the Risk This High? Dysplasia in the IBD Patient. Dysplasia in the Non IBD Patient. Increased Risk of CRC in Ulcerative Colitis
Screening for Colorectal Neoplasia in Inflammatory Bowel Disease Francis A. Farraye MD, MSc Clinical Director, Section of Gastroenterology Co-Director, Center for Digestive Disorders Boston Medical Center
More informationWithdrawal of drug therapy in patients with quiescent Crohn s disease
Withdrawal of drug therapy in patients with quiescent Crohn s disease DR. JEAN-FRÉDÉRIC COLOMBEL DIRECTOR OF THE IBD CENTER, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, USA Withdrawal of drug therapy
More informationHistological and immunological characteristics of colitis associated with anti-ctla 4 antibody therapy
Histological and immunological characteristics of colitis associated with anti-ctla 4 antibody therapy M. Perdiki 2, G. Bamias 1, D. Pouloudi 2, H. Gogas 3, I. Delladetsima 2 1 Academic Dpt. of Gastroenterology,
More informationProject context and main objectives
Executive summary Inflammatory bowel disease (IBD) refers to the separate but related conditions Crohn s disease (CD) and Ulcerative colitis (UC). IBD can appear at any stage in life, but is becoming increasingly
More informationCan We Predict the Natural History of Ulcerative Colitis? Edward V Loftus, Jr, MD Professor of Medicine Mayo Clinic Rochester, Minnesota, USA
Can We Predict the Natural History of Ulcerative Colitis? Edward V Loftus, Jr, MD Professor of Medicine Mayo Clinic Rochester, Minnesota, USA Endpoints Overview Hospitalization Surgery Colorectal cancer
More informationABBVIE VENTURES VISION. Drive strategic returns to AbbVie as a key constituent of overall corporate strategy
ABBVIE VENTURES ABBVIE VENTURES VISION Drive strategic returns to AbbVie as a key constituent of overall corporate strategy Early access to external innovation with a long-term horizon to generate meaningful
More informationInflammatory Bowel Disease A model for translational medicine. D P Jewell Professor Emeritus of Gastroenterology University of Oxford
Inflammatory Bowel Disease A model for translational medicine D P Jewell Professor Emeritus of Gastroenterology University of Oxford Samuel Wilks 1859, Pathological Treatises of Guy s Hospital The London
More informationCathepsin S Inhibitors for the Treatment of Inflammatory Bowel Disease. Therapeutic Area Partnerships Presentation.
Inhibitors for the Treatment of Inflammatory Bowel Disease Therapeutic Area Partnerships Presentation November 29, 2012 Cathepsin Cysteine Proteinases Fibrosis Cathepsin O Cathepsin B Cathepsin C Cathepsin
More informationUpdate in Pediatric IBD: 2018
Update in Pediatric IBD: 2018 Jeffrey S. Hyams, MD Head, Division of Digestive Diseases, Hepatology and Nutrition Mandell-Braunstein Family Endowed Chair in Pediatric Inflammatory Bowel Disease Connecticut
More informationNew treatment options in IBD: today and the future. Silvio Danese Istituto Clinico Humanitas, Milan, Italy
New treatment options in IBD: today and the future Silvio Danese Istituto Clinico Humanitas, Milan, Italy Date of preparation: October 2014 GLO/EYV/2014-00010h Overview of the late-stage IBD drug pipeline*
More informationClinical Trials in IBD. Bruce Yacyshyn MD Professor of Medicine Division of Digestive Diseases
Clinical Trials in IBD Bruce Yacyshyn MD Professor of Medicine Division of Digestive Diseases Objectives Today s discussion will address the following topics: Similarities and differences between Crohn
More informationNaltrexone for the treatment of Crohn s disease
Naltrexone for the treatment of Crohn s disease DR. NILESH CHANDE COORDINATING EDITOR, IBD REVIEW GROUP; UNIVERSITY OF WESTERN ONTARIO, LONDON, ON CANADA Opioid receptors 3 major types kappa κ delta δ
More informationEfficacy and Safety of Treatment for Pediatric IBD
Efficacy and Safety of Treatment for Pediatric IBD Andrew B. Grossman MD Co-Director, Center for Pediatric Inflammatory Bowel Disease Assistant Professor of Clinical Pediatrics Division of Gastroenterology,
More informationLatest Endoscopic Guidelines for FAP, HNPCC, IBD, and the General Population
Latest Endoscopic Guidelines for FAP, HNPCC, IBD, and the General Population David T. Rubin, M.D. Assistant Professor of Medicine Inflammatory Bowel Disease Center MacLean Center for Clinical Medical Ethics
More informationCASE DISCUSSION: The Patient with Dysplasia: Surgery or Active Surveillance? Noa Krugliak Cleveland, MD David T. Rubin, MD
CASE DISCUSSION: The Patient with Dysplasia: Surgery or Active Surveillance? Noa Krugliak Cleveland, MD David T. Rubin, MD Disclosure Statement NKC: No relevant conflicts to disclose. DTR: No relevant
More informationMicrobiome, Inflammation and Cancer
Microbiome, Inflammation and Cancer Anita Afzali MD, MPH, FACG Medical Director, OSU Inflammatory Bowel Disease Center Abercrombie & Fitch Endowed Chair in Inflammatory Bowel Disease 4 th Annual Cancer
More informationNature Genetics: doi: /ng Supplementary Figure 1
Supplementary Figure 1 Replicability of blood eqtl effects in ileal biopsies from the RISK study. eqtls detected in the vicinity of SNPs associated with IBD tend to show concordant effect size and direction
More informationPregnancy in IBD CDDW 2014
Pregnancy in IBD CDDW 2014 Brian Bressler MD, MS, FRCPC Director, Advanced IBD Training Program Clinical Assistant Professor of Medicine Division of Gastroenterology University of British Columbia Bressler
More informationNutrition and IBD. IBD Talk. Presented by. Hannah Price, paediatric dietitian at RHH. Lauren Farquhar, adult dietitian at RHH
Nutrition and IBD IBD Talk Presented by Hannah Price, paediatric dietitian at RHH Hannah.price@ths.tas.gov.au Lauren Farquhar, adult dietitian at RHH Lauren.farquhar@ths.tas.gov.au Microbiota and IBD The
More informationChromoendoscopy - Should It Be Standard of Care in IBD?
Chromoendoscopy - Should It Be Standard of Care in IBD? John F. Valentine, MD, FACG Professor of Medicine Division of Gastroenterology, Hepatology and Nutrition University of Utah What is the point of
More informationPROGRESS: Beginning to Understand the Genetic Predisposition to PSC
PROGRESS: Beginning to Understand the Genetic Predisposition to PSC Konstantinos N. Lazaridis, MD Associate Professor of Medicine Division of Gastroenterology and Hepatology Associate Director Center for
More informationExtrapolation & Pediatric Development: A case study from pediatric Ulcerative Colitis Richard Strauss, MD
Extrapolation & Pediatric Development: A case study from pediatric Ulcerative Colitis Richard Strauss, MD Immunology Clinical Development Janssen Research and Development Agenda Rationale for extrapolation
More informationPersonalized Medicine in IBD
Personalized Medicine in IBD Anita Afzali MD, MPH Assistant Professor of Medicine Director, Inflammatory Bowel Diseases Program University of Washington Harborview Medical Center CCFA April 2 nd, 2016
More informationColorado Powder Classic March 13-15, 2015 Vail Cascade Resort & Spa
Colorado Powder Classic March 13-15, 2015 Vail Cascade Resort & Spa For information, to register or for sponsorship opportunities: Visit: ColoradoPowderClassic.com Contact: Jeremy Stern 303-639-9163 x2
More informationPosition of Biologics in IBD Circa 2006: Top Down vs. Step Up Therapy
Position of Biologics in IBD Circa 2006: Top Down vs. Step Up Therapy Stephen B. Hanauer, MD University of Chicago Potential Conflicts: Centocor/Schering, Abbott, UCB, Elan, Berlex, PDL Goals of Treatment
More informationUse of extrapolation in small clinical trials:
Use of extrapolation in small clinical trials: Infliximab for pediatric ulcerative colitis Jessica J. Lee, MD, MMSc Medical Officer Division of Gastroenterology and Inborn Errors Products CDER/ FDA 1 Learning
More informationIBD What s in it for you?
Addenbrooke s NHS Trust IBD What s in it for you? Dr Miles Parkes Consultant Gastroenterologist Cambridge What is IBD? - inflammatory bowel disease Ulcerative colitis + Crohn s disease = main forms Incidence
More informationEndpoints for Stopping Treatment in UC
Endpoints for Stopping Treatment in UC Jana G. Hashash, MD Assistant Professor of Medicine Inflammatory Bowel Disease Center Division of Gastroenterology, Hepatology, and Nutrition University of Pittsburgh
More informationCarcinogenesis in IBD
Oxford Inflammatory Bowel Disease MasterClass Carcinogenesis in IBD Dr Simon Leedham, Oxford, UK Oxford Inflammatory Bowel Disease MasterClass Carcinogenesis in Inflammatory Bowel Disease Dr Simon Leedham
More informationImmunological Tolerance
Immunological Tolerance Definition: Making sure antibodies or T cells recognizing self components are either eliminated or brought under tight control. Failure of tolerance can lead to autoimmunity. (Also
More informationInflammation in the clinic
Inflammation in the clinic Stephen T. Holgate MRC Clinical Professor of Immunopharmacology ILSI Europe Workshop, Seville, May 14-15 2012 The immune system acts in four general ways to ensure host defence
More informationTHE ROLE OF MICROBIOME IN IBD
Disclosures THE ROLE OF MICROBIOME IN IBD Janssen UCB No relevance to the talk Subra Kugathasan, MD Professor of Pediatrics & Human Genetics Marcus Professor of Pediatric Gastroenterology Emory University
More informationPristane Induced Lupus Model
Pristane Induced Lupus Model Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease of unknown etiology, and for which approved therapies are inadequate. Current treatments rely on the
More informationCancer Risk with IBD Therapies How to Discuss with your Patients?
Cancer Risk with IBD Therapies How to Discuss with your Patients? Douglas L Nguyen, MD Assistant Clinical Professor of Medicine University of California, Irvine Medical Center H.H. Chao Comprehensive Digestive
More informationCCFA. Crohns Disease vs UC: What is the best treatment for me? November
CCFA Crohns Disease vs UC: What is the best treatment for me? November 8 2009 Ellen J. Scherl,, MD, FACP,AGAF Roberts Inflammatory Bowel Disease Center Weill Medical College Cornell University New York
More informationImmunogenicity of Biologic Agents and How to Prevent Sensitization
Immunogenicity of Biologic Agents and How to Prevent Sensitization William J. Sandborn, MD Professor and Chief, Division of Gastroenterology Director, UCSD IBD Center La Jolla, California, USA Learning
More informationEscherichia coli Nissle 1917
Immunoregulation in Inflammatory Bowel Diseases New therapeutic approaches Probiotics Escherichia coli Nissle 1917 Andreas Sturm Medizinische Klinik m.s. Hepatologie, Gastroenterologie, Endokrinologie
More informationBridges to excellence quality indicators in inflammatory bowel disease (IBD): differences between IBD and non-ibd gastroenterologists
ORIGINAL ARTICLE Annals of Gastroenterology (2017) 30, 1-5 Bridges to excellence quality indicators in inflammatory bowel disease (IBD): differences between IBD and non-ibd gastroenterologists Mohammad
More informationSpeaker Introduction
Speaker Introduction Stephen B. Hanauer, MD Professor of Medicine and Clinical Pharmacology University of Chicago Pritzker School of Medicine Chief of Gastroenterology, Hepatology, and Nutrition University
More information1. SZAKMAI ÖNÉLETRAJZ
1. SZAKMAI ÖNÉLETRAJZ NÉV: MUNKAKÖR: MUNKAHELY: Richárd Kellermayer, M.D., Ph.D. Assistant Professor Section of Pediatric Gastroenterology Hepatology and Nutrition, Baylor College of Medicine, Houston,
More informationSER-287 Phase 1b topline study results in patients with mild-to-moderate Ulcerative Colitis October 2, 2017
SER-287 Phase 1b topline study results in patients with mild-to-moderate Ulcerative Colitis October 2, 2017 Leading the Microbiome Revolution Forward Looking Statements Some of the statements in this presentation
More informationGenes, Genes, Everywhere! The key to a cure for IBD
Genes, Genes, Everywhere! The key to a cure for IBD Dermot McGovern MD, PhD, FRCP Director, Translational Medicine Professor of Medicine Joshua L and Lisa Z Greer Endowed Chair in IBD Genetics F. Widjaja
More informationSarkis K Mazmanian, California Institute of Technology
Sarkis K Mazmanian, California Institute of Technology The human microbiota The human gut harbors 10 11-10 12 bacteria per gram colonic content (>10 14 total bacteria) Total bacteria outnumber human cells
More informationAnne Griffiths MD, FRCPC. SickKids Hospital, University of Toronto. Buenos Aires, August 16, 2014
Management and Medical Therapies for Crohn disease: strategies to enhance mucosal healing Anne Griffiths MD, FRCPC SickKids Hospital, University of Toronto Buenos Aires, August 16, 2014 New onset Crohn
More informationSurgery and Stomas in IBD When do I need it? Can I avoid it? How do I live with it?
Surgery and Stomas in IBD When do I need it? Can I avoid it? How do I live with it? Kyle G. Cologne, MD Assistant Professor of Surgery USC Division of Colorectal Surgery Topics Surgical Differences between
More informationAlcoholic hepatitis is a drug-induced disorder
Alcoholic hepatitis is a drug-induced disorder Gyongyi Szabo, MD, PhD Professor of Medicine University of Massachusetts Medical School Source: 2 Sobernation.com Clinical Progression of ALD Mortality Acute
More informationDisclosures. What Do I Do When Anti-TNF Therapy Is Not Working Anymore? Fadi Hamid, M.D. Saint Luke s GI Specialists
What Do I Do When Anti-TNF Therapy Is Not Working Anymore? Fadi Hamid, M.D. Saint Luke s GI Specialists Disclosures No financial relationships to disclose. 1 Learning Objectives Case 24M with ileocolonic
More informationKey uncertainties around the evidence or technology are that the test has only been validated in biochemical studies.
pat hways PredictSure-IBD for inflammatory bowel disease prognosis Medtech innovation briefing Published: 25 March 2019 nice.org.uk/guidance/mib178 Summary The technology described in this briefing is
More information