Corporate Leadership Forum March Briefing March 11, 2015
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1 Center for Infectious Disease Research and Policy University of Minnesota Corporate Leadership Forum March Briefing March 11, 2015
2 Michael T. Osterholm, PhD, MPH McKnight Presidential Endowed Chair in Public Health Director, Center for Infectious Disease Research & Policy Distinguished University Teaching Professor, Division of Environmental Health Sciences, School of Public Health Professor, Technological Leadership Institute College of Science and Engineering Adjunct Professor, Medical School University of Minnesota
3 Global infectious disease risk and preparedness Ebola virus disease Middle East respiratory syndrome coronavirus infection (MERS-CoV) Avian influenza Influenza vaccine effectiveness Chikungunya Other infectious disease issues
4 Global infectious disease risk and preparedness Ebola virus disease Middle East respiratory syndrome coronavirus infection (MERS-CoV) Avian influenza Influenza vaccine effectiveness Chikungunya Other infectious disease issues
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10 Global infectious disease risk and preparedness Ebola virus disease Middle East respiratory syndrome coronavirus infection (MERS-CoV) Avian influenza Influenza vaccine effectiveness Chikungunya Other infectious disease issues
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22 Global infectious disease risk and preparedness Ebola virus disease Middle East respiratory syndrome coronavirus infection (MERS-CoV) Avian influenza Influenza vaccine effectiveness Chikungunya Other infectious disease issues
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27 The MERS Transmission Model
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32 MERS More data gaps than knowledge Transmission Prevention Treatment Similar to SARS but different Air travel has changed significantly
33 Global infectious disease risk and preparedness Ebola virus disease Middle East respiratory syndrome coronavirus infection (MERS-CoV) Avian influenza Chikungunya Other infectious disease issues
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35 Cases Deceased Cases Alive Source: WHO, Flutrackers, news reports
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37 Location of H7N9 Influenza in China (3/7/15)* Russia HEILONGJIANG Mongolia *626 total cases/153 deaths Province/ City Number of Cases Anhui 25 Beijing 6 Fujian 58 INNER MONGOLIA JILIN Guangdong 195 XINJIANG BEIJING LIAONING North Korea Guizhou 1 Pakistan QINGHAI NINGXIA SHANXI TIANJIN HEBEI SHANDONG South Korea Guangxi 3 Hebei 1 GANSU SHAANXI HENAN JIANGSU Henan 4 India Nepal XIZANG Bhutan Bangladesh SICHUAN YUNNAN SHANGHAI ANHUI HUBEI ZHEJIANG CHONGQING HUNAN JIANGXI GUIZHOU FUJIAN Taiwan GUANGXI GUANGDONG Hunan 24 Jiangsu 68 Jiangxi 10 Jilin 2 Burma Vietnam Shandong 4 Laos HAINAN Philippines Shanghai 44 Thailand Kilometers 500 Miles Xinjiang 9 Zhejiang 160
38 Infection of Poultry with H7N9 Influenza Virus Study conducted to evaluate the possible route of transmission in poultry Minnesota CEIRS group worked with SEPRL/USDA Study Design Chickens, quail and pigeons infected with A/Anhui/1/2013 H7N EID 50 given intranasally; evaluated on Day 2 and 4 Specimens collected via OP or CS and evaluated via real time RT PCR using H7 specific primers Contact transmission studies also performed
39 CT Values from Infected Poultry Day 4 Post Infection Inoculation Dose Group # birds infected OP values CL values 10 2 Quail 2/ Quail 5/ Quail 11/ Pigeons 0/5 neg neg 10 4 Pigeons 0/5 neg neg 10 6 Pigeons 1/11 31 neg 10 6 Chicken 10/ CT value 29 is strongly positive for H7 HA CT value moderate levels of H7 HA CT value low levels of H7 HA
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49 Global infectious disease risk and preparedness Ebola virus disease Middle East respiratory syndrome coronavirus infection (MERS-CoV) Avian influenza Influenza vaccine effectiveness Chikungunya Other infectious disease issues
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55 Global infectious disease risk and preparedness Ebola virus disease Middle East respiratory syndrome coronavirus infection (MERS-CoV) Avian influenza Influenza vaccine effectiveness Chikungunya Other infectious disease issues
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57 Aedes albopictus Female
58 Charrel R et al. N Engl J Med 2007;356: World Distribution of the Aedes albopictus Mosquito World Distribution of the Aedes albopictus Mosquito
59 Aedes aegypti
60 Aedes aegypti Distribution in the Americas
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66 Global infectious disease risk and preparedness Ebola virus disease Middle East respiratory syndrome coronavirus infection (MERS-CoV) Avian influenza Influenza vaccine effectiveness Chikungunya Other infectious disease issues
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74 If you don t know where you re going, any road will get you there. - Lewis Carroll
75 Are these the shadows of the things that Will be, or are they shadows of things that May be, only? Ebenezer Scrooge
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