Report on virological surveillance of influenza activity in the Romania 2014/15 season
|
|
- Mabel Roberta West
- 5 years ago
- Views:
Transcription
1 National Institute for Research Cantacuzino National Influenza Centre, Laboratory for Respiratory Viruses Spl.Independentei 103, sector 5, Bucuresti Romania Report on virological surveillance of influenza activity in the Romania 2014/15 season Summary In Romania, the influenza epidemic of 2014/15 season started in the week 4/2015, when more than 10% of samples tested were positive for influenza. The influenza activity was higher than in previous season and characterised by co-circulation of influenza A(H3N2), A(H1N1)pdm09 and B viruses. First influenza virus from sentinel system was detected in week 49/2014, a significant rise of positive specimens started in week 3/2015, and the highest number of influenza positive specimens were detected in week 9. Last positive detections were registered during week 18/ In ILI sentinel and non-sentinel system, 931 specimens collected were tested by real-time RT- PCR out of which 500 (54.8%) were positive for influenza virus: 290 (58%) influenza A and 210 (42%) influenza B, including two coinfections of A(H3N2) and B influenza. Of the influenza A cases subtyped, 110 (38%) were H1N1 pdm09 and 180 (62%) were H3N2. In SARI sentinel system 407 specimens collected were tested by real-time RT-PCR and 164 (41%) were positive for influenza virus: 99 (60.4%) influenza A and 65 (39.6%) influenza B, including two coinfections (H3N2 and B; H1N1 and B). Of the influenza A cases, 52 (52.5%) were subtyped as H1N1 pdm09 and 47 (47.5%) as H3N2. From a total of 243 negative influenza virus samples, 55 were tested for other respiratory viruses and 34 of them were positive (including four coinfections). A total of 111 strains were isolated on MDCK or MDCK SIAT1 cells (31 strains H1N1 pdm09, 18 strains H3N2 and 62 strains type B Yamagata lineage). With available antisera all A(H1N1)pdm09 viruses were antigenically characterized as A/California/7/2009, but a higher heterogeneity was observed for subtype H3N2 and type B, indicating a mismatch between circulating and vaccine strains. Thirty five strains were tested for antiviral sensitivity, oseltamivir and zanamivir, by phenotypic method. Genetically, all A(H1N1)pdm09 viruses fall in group 6, subgroup B (A/South Africa/3626/2013). All B type viruses belonged to clade 3 (B/Phuket/3073/2013). The A(H3N2) strains belonged to clades 3C.2 and 3C.3. 1
2 Methods In Romania, the influenza surveillance is coordinated by the National Institute for Public Health (INSP) in close collaboration with the National Influenza Centre located in Cantacuzino Institute in Bucharest. In this season the sentinel system was based on 193 general practitioner doctors (GPs) distributed across 15 counties and Bucharest. Severe acute respiratory infection (SARI) surveillance was based on twenty hospitals (emergency hospitals, infectious diseases, pulmonary and paediatric hospitals) from 6 counties and Bucharest Municipality. From week 46 until the onset of influenza activity samples from the first 3 detected SARI cases in each sentinel hospital were tested for influenza; after that, one sample from the first detected SARI case. Throat swabs were collected randomly from ILI/SARI patients. These specimens were examined for the presence of influenza viruses (IV). The following genes are targeted by rrt-pcr tests: type A and B influenza matrix gene; haemagglutinin gene specific for influenza A subtypes: H1N1 pdm09 virus (formerly pandemic A(H1N1) and A(H3N2). When influenza A viruses were detected, a second rrt-pcr analysis was performed on the HA gene for determination of H1N1 pdm09 or H3N2 subtype. When influenza B viruses were detected, a second rrt-pcr analysis was performed for lineage determination (Yamagata or Victoria lineages). Other respiratory viruses were tested by Multiplex RT-PCR SEEPLEX RV 15 ONE-STEP Kit (Seegene.Inc., Seoul, Koreea), based on classic RT-PCR according with the manufactured work protocol. In house classic RT-PCR will be used as an alternative test for CoV, ADV or RSV. The selection method for virus isolation/sequencing use as criteria: Specimens in balance number of each type/subtype during all influenza season. Selected influenza vaccinated and nonvaccinated cases. Ct value under 30 Influenza virus isolation was performed on MDCK (ATCC/CCL 34) and MDCK SIAT1 for influenza virus A(H3N2). The presence of multiplied virus is revealed by hemagglutination with 0.5% turkey red blood cells (type A, subtype H1N1 pdm09 and type B) and 0.75% guinea pig erythrocytes (type A, subtype H3N2). Influenza virus isolates were characterized antigenically with haemagglutination inhibition (HI) assay using turkey/guinea pig red blood cells. For influenza A(H3N2) characterization we employ a modified HI assay with guinea pig erythrocytes in the presence of 20nM oseltamivir. HI test is performed in U bottom 96-well microtiter plates. Two-fold serial dilutions of standard ferret sera (25 µl system) are mixed with an equal volume of diluent containing each influenza virus isolate or standard antigen at 4 HA units/25 µl. After incubation minutes at room temperature (15-30ºC), 50 µl of erythrocytes suspension is then added to every well on all plates 2
3 and incubated for minutes at room temperature (15-30ºC). Plates are then tilted and read for agglutination. We are using the traditional sequencing technique ( the Sanger reaction ) to monitor influenza evolution for at least 10% of original specimens detected positive, for whole HA gene. The phylogenetic trees are constructed using FastTree version 2.1.7with GTRGAMMA substitution model and bootstraps. Trees were drawn using FigTree and Inkscape as scalable vector graphics editor. SNP genotyping is used to screen for H275Y substitution in NA gene of H1N1 pdm09. Results Influenza Virus (IV) detections in ILI cases Since the beginning of the season, 913 clinical specimens, representing ILI suspected cases, collected from sentinel and non-sentinel sources, have been tested by real-time RT-PCR. Thirty eight percent of specimens were collected from non-sentinel system. The positivity rate began to rise in the second week of January (27%), while the highest rates were in weeks 7-9 (more than 70%). Last positive detection was at the end of April, albeit with very few specimens after early April and May. Second part of the epidemic was characterized by a dominance of type B. Distributions by type/subtype in ILI cases from sentinel and non-sentinel systems is presented in table 1. Table 1. Distributions of influenza virus detections by type/subtype in ILI cases sentinel and non-sentinel systems. 559 ILI from sentinel system primary care (61.2%) 354 ILI from nonsentinel system (38.8%) Total samples N = 913 ILI % Total pos A&B (54.2%) 197 (55.6) type A (62.4) 101 (51.3) A/H1 pdm (38.1) 38 (37.6) A/H (61.9) 63 (62.4) type B (37.6) 96 (48.7) Neg (45.8) 157 (44.4) A mixed virological aspect was noticed, with a slight dominance of type A over type B and a dominance of subtype H3N2 over H1N1 pdm09, both in the primary care system and among non-sentinel patients (generally hospitalized patients). Two mixed infections were detected: A (H3N2) and B. The weekly distribution of positive samples are presented figure 1. 3
4 * Influenza and non-influenza viruses detections in SARI cases Since the beginning of the season, 407 clinical specimens collected from sentinel sources have been tested by real-time RT-PCR, out of which 164 (40.3%) were positive for influenza virus: 99 specimens type A (52 H1N1 pdm09, 47 H3N2) and 65 type B. Weekly distribution and their proportion weight are presented in figure 2 and 3. From a total of 243 influenza virus negative samples, 55 (22.6%) were tested for other respiratory etiology. Thirty four of them were positive for other respiratory viruses, of which 18 (53%) for RSV. We found four non influenza virus coinfections, as follows: RSV&EV, RSV&AdV, RSV&RhV and AdV&EV. Figure 1. Weekly distribution of influenza virus detection in in ILI and SARI ILI GPs: Total = Neg: 256 (45.8%) - Pos: 303 (54.2%) - H3: 117 (38.6%) - H1: 72 (23.8%) - B: 114 (37.6%) ILI hospitalized: Total = Neg: 157 (44.4%) - Pos: 197 (55.6%) - H3: 63 (32%) - H1: 38 (19.3%) - B: 96 (48.7%) SARI: Total = Neg: 209 (51.4%) Total Pos: 198 (48.6%) Influenza: H3: 47 (28.7%) - H1: 52 (31.7%) - B: 65 (39.6%) - Pos Non-influenza : H3 H1pdm09 B Others 4
5 # detections 40 Figure 2. Weekly distribution of SARI cases ' 8*# ^ H1N1pdm09 A/H3N2 B RSV hmpv PIV 1 PIV3 PIV 2 PIV 4 Corona ADV Rhino Boca HEV Figure 3. Distribution of respiratory viruses in SARI samples 9% 8% 26% 33% 24% IV H1pdm09 IV H3 IV type B RSV Other Regarding groups of age, the smallest percentage of positive influenza virus specimens was registered for 0-4 years old (16.2%) but a high percentage of other respiratory viruses was registered within this group (Table 2 and Figure 4). All positive specimens for other respiratory viruses were from children 5 year old. Type A influenza virus was dominant, except groups 5-14 and years, where 50% were type B. Subtype H3 was dominant in extreme age groups (0-4 and 64) and subtype H1 pdm09 in subjects belonging to years. 5
6 No. of samples Table 2. Distribution by age groups of influenza virus detection in SARI patients. Group of Total % % pos./age % pos. # % pos. age specimens specimens # pos # H1 H1 H3 H3 # B % pos. B * Unknown Total *one coinfection H1 pdm09&b, one coinfection H3&B Figure 4. Distribution of positive detection in SARI cases by age groups H1 H3 B Pos. other resp. viruses * >64 Unknown Antigenic characterization: Influenza virus isolation on MDCK (ATCC/CCL 34) and MDCK SIAT1 for influenza virus A(H3N2) was performed for 16% of positive specimens, usually after 1-2 passages. The presence of multiplied virus is revealed by hemagglutination with 0.5% turkey red blood cells 6
7 (type A, subtype H1N1 pdm09 and type B) and 0.75% guinea pig erythrocytes (type A, subtype H3N2). The weekly distribution of influenza virus isolates is presented in Figure 5. It was very difficult to isolate influenza A (H3N2) viruses compared with type B and A(H1N1 pdm09). A (H3N2) strains have multiplied at low titer and it was difficult to be characterized by HI assay. However, a total of 111 strains were isolated: - 31 strains H1N1 pdm09, A/California/7/09-like - 18 strains H3N2: o 6 strains A/Texas/50/ like and o 12 strains A/Switzerland/ /2013 like - 62 strains type B (B/Yamagata/16/88 lineage): o 9 strains B/Massachusetts/02/2012-like o 53 strains B/Phuket/3073/2013-like. Forty two were from hospitalized patients (ILI or SARI). Thirty three isolates were sent to WHO Collaborating Center for Reference and Research on Influenza, Medical Research Council National Institute for Medical Research (NIMR), London. A total of 35 strains of influenza virus isolates were tested by phenotypic method (NA-Star assay) to oseltamivir and zanamivir. All investigated influenza A and B strains were susceptible to neuraminidase inhibitors. Figure 5. Weekly distribution of influenza virus isolation in in ILI/SARI sentinel and nonsentinel Romania H3 B H1pdm09 week 7
8 Genetic characterization: Sequencing of HA gene was performed for 54 of original samples or isolates figures 6, 7 and 8. Full hemagglutinin H1pdm09 gene was sequenced from 19 original specimens (including an influenza B and H1N1 coinfection), out of which 14 were collected from patients hospitalized with SARI. Four of them had fatal evolution, although one patient had been vaccinated. All characterized viruses fell into clade A/California/7/2009, subgroup 6B, A/South Africa/3626/2013 (figure 6). Twenty H3 subtype strains clustered into three different clades, 3C.2a and 3C.3a or 3C.3b: o Eight strains falling in clade representative A/Perth/16/2009 A/HongKong/5738/2014 group (3C.2a) o Seven strains falling in clade representative A/Perth/16/2009 A/Switzerland/ /2013 (3C.3a); o Five strains falling in clade representative A/Perth/16/2009 A/Newcastle/22/2014 (3C.3b) Of note: most of the viruses sequenced last season (2013/2014) belonged to clade 3C.3 (figure 7). Sixteen type B viruses fell into clade 3 (B/Phuket/3073/2013) figure 8, four from vaccinated patients and three deaths. In addition, all influenza B positive specimens tested for lineage differentiation by SNP belonged to B/Yamagata lineage. 8
9 Figure 6. Phylogenetic analysis of influenza H1N1 pdm09 HA genes compared to vaccine strain and previous season strains 9
10 Figure 7. Phylogenetic analysis of influenza A(H3N2) HA genes compared to vaccine strain and previous season strains 10
11 Figure 8. Phylogenetic analysis of influenza B HA genes compared to vaccine strain and previous season strains 11
12 Acknowledgements. We acknowledge the technical work performed by Luiza Ustea, Emilia Dobre, Nuti Enache and Mirela Ene. Special thanks to George Necula and Sorin Dinu, who gave us valuable advice in the field of genetic analysis. Special thanks to Odette Popovici, MD, senior epidemiologist, National Institute of Public Health, Romanian CDC, focal point for SARI surveillance and Rodica Popescu, MD, senior epidemiologist, National Institute of Public Health, Romanian CDC, focal point for ILI surveillance. We acknowledge the hard work performed by sentinel physicians and their patients and other contributors in influenza surveillance. Report prepared by Alina Elena Ivanciuc, Mihaela Lazãr, Cristina Tecu, Maria Elena Mihai, Carmen Maria Cherciu, Daniela Pitigoi and Emilia Lupulescu 12
WHO NIC at Research Institute of Influenza and D.I. Ivanovsky Institute of Virology INTEGRATED DATA OF INFLUENZA MORBIDITY AND DIAGNOSIS
WHO NIC at Research Institute of Influenza and D.I. Ivanovsky Institute of Virology 1 of 7 Year: 2018 Week: 6 Period: 05.02.2018-11.02.2018 Influenza and ARI morbidity data Epidemiological data show increase
More informationMASSACHUSETTS DEPARTMENT OF PUBLIC HEALTH WEEKLY INFLUENZA UPDATE January 26, 2018
MASSACHUSETTS DEPARTMENT OF PUBLIC HEALTH WEEKLY INFLUENZA UPDATE January 26, 2018 All data in this report are preliminary and subject to change as more information is received. Sentinel Provider Surveillance:
More informationSummary. Primary care data. Week 49/2014. Season
Summary Week 49/2014 In week 49/2014, influenza activity remained low across the WHO European Region. Twenty countries reported sporadic influenza activity and nine reported increasing trends in consultations
More informationMASSACHUSETTS DEPARTMENT OF PUBLIC HEALTH WEEKLY INFLUENZA UPDATE January 4, 2019
MASSACHUSETTS DEPARTMENT OF PUBLIC HEALTH WEEKLY INFLUENZA UPDATE January 4, 2019 All data in this report are preliminary and subject to change as more information is received. Sentinel Provider Surveillance:
More informationSummary. Week 11/2017 (13 19 March 2017) Season overview
Summary Week 11/2017 (13 19 March 2017) Influenza activity across the region continued to decrease with the great majority of countries reporting low intensity. The proportion of influenza virus detections
More informationChinese Influenza Weekly Report
Chinese Influenza Weekly Report (All data are preliminary and may change as more reports are received) Summary During week 5, influenza activity is at intra-seasonal levels both in southern and northern
More informationAnnual Epidemiological Report DRAFT
December 2018 Annual Epidemiological Report DRAFT Key Facts - 2017/2018 Influenza Season Influenza and Other Seasonal Respiratory Viruses in Ireland, 2017/2018 Key Facts 2017/2018 Influenza Season The
More informationWeekly influenza surveillance overview
SURVEILLANCE REPORT Weekly influenza surveillance overview 7 February 2014 Main surveillance developments in week 5/2014 (27 January 2014 2 February 2014) This first page contains the main developments
More informationWHO NIC at Research Institute of Influenza and D.I. Ivanovsky Institute of Virology INTEGRATED DATA OF INFLUENZA MORBIDITY AND DIAGNOSIS
WHO NIC at Research Institute of Influenza and D.I. Ivanovsky Institute of Virology 1 of 7 Year: 2019 Week: 8 Period: 18.02.2019-24.02.2019 Influenza and ARI morbidity data Epidemiological data show decrease
More informationTECHNICAL DOCUMENT. Influenza virus characterisation. Influenza A(H3N2) virus analysis. Summary Europe, December Summary
Community Network of Reference Laboratories (CNRL) for Human Influenza in Europe Influenza virus characterisation Summary Europe, December 2011 Summary Since week 40/2011, influenza A(H1N1)pdm09, influenza
More informationSummary. Week 15/2018 (9 15 April 2018) season overview
Summary Week 15/2018 (9 15 April 2018) Influenza viruses continued to circulate in the Region with 26% of the individuals sampled from primary healthcare settings testing positive, while all countries
More informationChinese Influenza Weekly Report
Chinese Influenza Weekly Report (All data are preliminary and may change as more reports are received) Summary During week 10, influenza activity was still a little high in southern and northern China
More informationChinese Influenza Weekly Report
Chinese Influenza Weekly Report (All data are preliminary and may change as more reports are received) Summary During week 13, influenza activity was still a little high in mainland China, and it was increasing
More informationInfluenza Global Epidemiologic Update
Influenza Global Epidemiologic Update November 10 th, 2017 1. GLOBAL WHO SUMMARY based on data up to 15 October 2017 North America: Overall influenza virus activity remained low, with detections of predominantly
More informationInfluenza Surveillance in Ireland Weekly Report Influenza Week (22 nd 28 th January 2018)
Influenza Surveillance in Ireland Weekly Report Influenza Week 4 218 (22 nd 28 th January 218) Summary Overall, influenza activity in Ireland remained widespread and at high levels during week 4 218 (week
More informationInfluenza Surveillance in Ireland Weekly Report Influenza Weeks 13 & (26 th March 8 th April 2018)
Influenza Surveillance in Ireland Weekly Report Influenza Weeks 13 & 14 218 (26 th March 8 th April 218) Summary All indicators of influenza activity continued to decrease during weeks 13 and 14 218 (week
More informationInfluenza Surveillance in Ireland Weekly Report Influenza Week (12 th 18 th March 2018)
Influenza Surveillance in Ireland Weekly Report Influenza Week 11 218 (12 th 18 th March 218) Summary Overall, during week 11 218 (week ending 18 th March 218), all indicators of influenza activity have
More informationQuestions and Answers
Questions and Answers Recommended composition of influenza virus vaccines for use in the southern hemisphere 2016 influenza season and development of candidate vaccine viruses for pandemic preparedness
More informationSummary. Week 13/2018 (26 31 March 2018) season overview
Summary Week 13/2018 (26 31 March 2018) Influenza viruses continued to circulate in the Region, while all countries reported low or medium intensity of activity of respiratory infections. Influenza continued
More informationInfluenza Update N 157
Influenza Update N 157 13 April 2012 Summary In most areas of the northern hemisphere temperate regions, influenza activity appears to have peaked and is declining. In North America, influenza indicators
More informationInfluenza Activity Update
Influenza Activity Update Tiffany D Mello, MPH, MBA Influenza Surveillance and Outbreak Response Team Epidemiology and Prevention Branch Influenza Division National Adult and Influenza Immunization Summit
More informationSummary. Week 4/2018 (22 28 January 2018) season overview
Summary Week 4/2018 (22 28 January 2018) Influenza activity was widespread in the majority of reporting countries and while activity was increasing, intensity in most countries was reported as low to medium.
More informationWeekly Influenza & Respiratory Illness Activity Report
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending February
More informationGlobal Influenza Virus Surveillance and WHO Influenza Vaccine Virus Recommendations for the Northern Hemisphere Influenza Season
Global Influenza Virus Surveillance and WHO Influenza Vaccine Virus Recommendations for the Northern Hemisphere 2015-16 Influenza Season Jacqueline Katz, Ph. D. Deputy Director (acting), Influenza Division
More informationRisk assessment of seasonal influenza - Update, EU/EEA, January 2017
RAPID RISK ASSESSMENT Risk assessment of seasonal influenza - Update, EU/EEA, 2016-2017 24 January 2017 Conclusions and options for response Most countries with high influenza activity have reported severe
More informationInfluenza Weekly Surveillance Bulletin
Influenza Weekly Surveillance Bulletin Northern Ireland, Weeks 17-18 (25 April 216 8 May 216) Summary In Northern Ireland, as of weeks 17-18 216, the 215/16 influenza season has seen low community influenza
More informationInfluenza Surveillance in Ireland Weekly Report Influenza Week (11 th 17 th December 2017)
Influenza Surveillance in Ireland Weekly Report Influenza Week 5 217 (11 th 17 th December 217) Summary Most indicators of influenza activity in Ireland have continued to increase during week 5 217 (week
More informationTexas Influenza Summary Report, Season (September 28, 2008 April 11, 2009)
Texas Influenza Summary Report, 2008 2009 Season (September 28, 2008 April 11, 2009) Background Influenza and influenza-like illnesses (ILI) were last reportable by law in any county in Texas in 1993 (1).
More informationCommunity and Hospital Surveillance
6SSN 2324-497 Community and Hospital Surveillance ILI, SARI, Influenza and Respiratory Pathogens 217 Influenza Season, Week 3, ending 3 July 217 SUMMARY Influenza-like illness (ILI) consultation rates
More informationSeasonal Influenza Report
Key findings for the 218 219 flu season Current Week (Week 2) Current Season Summary January 6 January 12, 219 ICU cases under 65 years: Deaths September 3, 218 January 12, 219 3 ICU cases under 65 years:
More informationSeasonal Influenza Report
Seasonal Influenza Report 218 219 CDC Disease Week 45 (November 4 November 1, 218) Updated November 13, 218 Key findings for the 218 219 flu season Current Week (Week 45) Current Season Summary November
More informationSARI, Influenza and Respiratory Pathogens
ISSN 2324-3589 Hospital Surveillance SARI, Influenza and Respiratory Pathogens Monthly Report, November 15 SUMMARY During weeks 45-48 (2 November 29 November 15), influenza activity decreased in hospital
More informationvirus characterisation
SURVEILLANCE REPORT Influenza Influenza virus virus characterisation Summary Europe, July 2012 Summary Europe, May 2014 Summary During the 2013 14 season A(H1N1)pdm09, A(H3N2), B/Victoria- and B/Yamagata-lineage
More informationSurveillance Overview
Number of Positive Specimens Percent Positive Number of Positive Specimens National Center for Immunization & Respiratory Diseases 2016-17 Surveillance Overview Lynnette Brammer, MPH Epidemiologist, Influenza
More informationCommunity and Hospital Surveillance
ISSN 2324-497 Community and Hospital Surveillance ILI, SARI, Influenza and Respiratory Pathogens 15 Influenza Season, Week 27, ending 5 July 15 SUMMARY During week 27 (29 June 5 July 15), influenza activity
More informationDecember 3 to 9, 2017 (Week 49)
Hanks you December 3 to 9, 2017 (Week 49) Overall Summary Overall, Influenza activity continues to increase across Canada; however many indicators such as hospitalizations, outbreaks and geographic spread
More informationChinese Influenza Weekly Report
National Institute for Viral Disease Control and Prevention, China CDC Chinese Weekly Report (All data are preliminary and may change as more reports are received) Summary During week 17, influenza activity
More information12 to 18 January, 2014 (Week 03)
Hanks you 12 to 18 January, 2014 (Week 03) Overall Summary In week 03, overall laboratory detections of influenza decreased slightly, reflecting decreased activity in some regions that experienced an earlier
More informationApril 8 to April 14, 2012 (Week 15)
Hanks you April 8 to April 14, 212 (Week 15) Overall Influenza Summary The peak of activity for the 211-212 influenza season in Canada has passed as most indicators of influenza activity continue to decline.
More informationInfluenza Weekly Surveillance Bulletin
Influenza Weekly Surveillance Bulletin Northern Ireland, Week 3 (12 January 215 18 January 215) Summary GP Influenza activity in Northern Ireland has slightly decreased while virological detections have
More informationSARI, Influenza and Respiratory Pathogens
ISSN 2324-3589 Hospital Surveillance SARI, Influenza and Respiratory Pathogens Monthly Report, April 15 SUMMARY During weeks 14-17 ( March 26 April 15), influenza activity remained low in hospital surveillance
More informationMinnesota Influenza Geographic Spread
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending February
More informationInfluenza Weekly Surveillance Bulletin
Influenza Weekly Surveillance Bulletin Northern Ireland, Week 14 (4 April 216 1 April 216) Summary In Northern Ireland, as of week 14 216, the 215/16 influenza season has seen low community influenza activity,
More informationNovember 5 to 11, 2017 (Week 45)
Hanks you Overall Summary November 5 to 11, 2017 (Week 45) Influenza activity crossed the seasonal threshold in week 45, indicating the beginning of the influenza season at the national level. The number
More informationWeekly Influenza & Respiratory Illness Activity Report
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending March
More informationMinnesota Influenza Geographic Spread
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending March
More informationOntario Respiratory Pathogen Bulletin I
Ontario Respiratory Pathogen Bulletin I 2017-2018 SURVEILLANCE WEEK 3 (January 14, 2018 January 20, 2018) This issue of the Ontario Respiratory Pathogen Bulletin provides information on the surveillance
More informationMinnesota Influenza Geographic Spread
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending February
More informationInfluenza Surveillance in Ireland Weekly Report Influenza Week (12 th 18 th November 2018)
Influenza Surveillance in Ireland Weekly Report Influenza Week 46 2018 (12 th 18 th November 2018) Summary All indicators of influenza activity in Ireland were at low levels during week 46 2018 (week ending
More informationSurveillance of Influenza in Northern Ireland
Surveillance of Influenza in Northern Ireland 2016 2017 Contents Summary... 1 Introduction... 3 Enhanced influenza surveillance systems... 3 In-hours Sentinel GP Practice surveillance... 3 GP Out-of-Hours
More informationInfluenza Surveillance in Ireland Weekly Report Influenza Week (1 st 7 th October 2018)
Influenza Surveillance in Ireland Weekly Report Influenza Week 40 2018 (1 st 7 th October 2018) Summary This is the first influenza surveillance report of the 2018/2019 influenza season. All indicators
More informationMain conclusions and options for response
RAPID RISK ASSESSMENT Risk assessment of seasonal influenza, EU/EEA, 2017-2018 19 December 2017 Main conclusions and options for response The influenza season started in week 48/2017 with 11 EU/EEA countries
More informationSeasonal Influenza Report
Key findings for the 2017 2018 flu season Seasonal Influenza Report 2017 2018 Influenza activity remains elevated throughout California. As of 2018 week 9 (February 25 March 3, 2018), the statewide geographic
More informationMinnesota Influenza Geographic Spread
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending January
More informationVirological Surveillance of Influenza in Belgium
Virological Surveillance of Influenza in Belgium Season 2017-2018 VIRAL DISEASES National Influenza Centre (WHO) Isabelle Thomas, Cyril Barbezange, Steven Van Gucht Jeannine Weyckmans, Ilham Fdillate,
More informationREPORT. Early risk assessment: What to expect of the 2017/18 influenza season in Norway
2017 REPORT Early risk assessment: What to expect of the 2017/18 influenza season in Norway Early risk assessment: What to expect of the 2017/18 influenza season in Norway Department of Influenza 2 Published
More informationMinnesota Influenza Geographic Spread
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending April
More informationTable 1: Summary of Texas Influenza (Flu) and Influenza-like Illness (ILI) Activity for the Current Week Texas Surveillance Component
Texas Surveillance Report 2017 2018 Season/2018 MMWR Week 03 (Jan. 14, 2018 Jan. 20, 2018) Report produced on 1/27/2018 Summary activity remains high across the state of Texas. Compared to the previous
More informationMinnesota Influenza Geographic Spread
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending December
More informationSeasonal Influenza Report
Key findings for the 2017 2018 flu season Seasonal Influenza Report 2017 2018 Influenza activity is widely circulating in California. As of week 52 (December 24 30, 2017), the statewide geographic distribution
More informationMinnesota Influenza Geographic Spread
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending March
More informationInfluenza Weekly Surveillance Bulletin
Influenza Weekly Surveillance Bulletin Northern Ireland, Week 1 (2 January 217 8 January 217) Summary At this point in the 216/17 influenza season, activity has increased in week 1 (week commencing 9 th
More informationMinnesota Influenza Geographic Spread
Weekly Influenza & Respiratory Illness Activity Report A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control Week Ending October
More informationCenters for Disease Control and Prevention U.S. INFLUENZA SEASON SUMMARY*
1 of 6 11/8/2012 1:35 PM Centers for Disease Control and Prevention 2004-05 U.S. INFLUENZA SEASON SUMMARY* NOTE: This document is provided for historical purposes only and may not reflect the most accurate
More informationInfluenza Surveillance Summary: Denton County Hospitals and Providers 17.51% 15.95% 10.94% 7.41% 9.01% 8.08%
DENTON COUNTY PUBLIC HEALTH 2016 2017 INFLUENZA SURVEILLANCE PROGRAM CDC WEEK 13, WEEK ENDING APRIL 7, 2017 Epidemiologic Overview Denton County Low influenza activity was reported in Denton County for
More informationNovember 9 to 15, 2014 (week 46)
Hanks you November 9 to 15, 2014 (week 46) Overall Summary In week 46, overall influenza activity increased from the previous week with sporadic activity reported in six provinces and one territory. Low-level
More informationAntiviral-resistant B viruses with a novel mutation detected by antiviral resistance surveillance in Japan
6thMeeting of NICs in the WPR and SEAR 29-31 May, 2012 Hanoi VN Antiviral-resistant B viruses with a novel mutation detected by antiviral resistance surveillance in Japan Masaki Imai WHO Collaborating
More informationRAPID RISK ASSESSMENT. Risk assessment of seasonal influenza, EU/EEA, Conclusions and options for response. Update, 25 January 2017
RAPID RISK ASSESSMENT Risk assessment of seasonal influenza, EU/EEA, 2016 2017 Update, 25 January 2017 Conclusions and options for response Most countries with high influenza activity have reported appreciable
More informationSeasonal Influenza Report
Key findings for the 2017 2018 flu season October 1 st, 2017 (CDC Disease Week 40) marked the beginning of the 2017 2018 influenza season. Influenza activity is increasing in California. As of November
More informationvirus characterisation
SURVEILLANCE REPORT Influenza Influenza virus virus characterisation Summary Europe, March July 2012 2013 Summary During the 2012 13 season, A(H1N1)pdm09, A(H3N2) and B/Victoria- and B/Yamagata-lineage
More informationREAGENTS FOR THE TYPING OF HUMAN INFLUENZA ISOLATES 2017
REAGENTS FOR THE TYPING OF HUMAN INFLUENZA ISOLATES 2017 This product was developed by the Victorian Infectious Diseases Reference Laboratory (VIDRL) in its capacity as a WHO Collaborating Centre for Reference
More informationUpdate on influenza monitoring and vaccine development
Update on influenza monitoring and vaccine development Annette Fox WHO Collaborating Centre for Reference and Research on Influenza at The Peter Doherty Institute for Infection and Immunity 1 Outline Why
More informationRESPIRATORY VIRUS SURVEILLANCE REPORT
RESPIRATORY VIRUS SURVEILLANCE REPORT Week Ending January 20, 2018 Wisconsin Department of Health Services Division of Public Health Bureau of Communicable Diseases Communicable Diseases Epidemiology Section
More informationGIHSN-China s experience & Results of season Beijing, China
GIHSN-China s experience & Results of season 2015-2016 Beijing, China 1. Chinese Center for Disease Control and Prevention 2.WHO Collaborating Centre for Infectious Disease Control and Epidemiology, School
More informationWeek 11 (Mar.13 19, 2016)
Manitoba Health, Healthy Living and Seniors (MHHLS) Influenza Surveillance `Week 215 216 53: Dec 28, 214 Jan 3, 215 Week 11 (Mar.13 19, 216) Data extracted Mar. 24, 216 at 11: am Laboratory-confirmed influenza
More informationChinese Influenza Weekly Report
Chinese Influenza Weekly Report (All data are preliminary and may change as more reports are received) Summary During week 26, influenza activity level in mainland China was very low, only a few A(H1N1)pdm09
More informationWhat to expect of the 2018/19 influenza season in Norway
REPORT 2019 EARLY RISK ASSESSMENT: What to expect of the 2018/19 influenza season in Norway Karoline Bragstad Kristian Waalen Trine Hessevik Paulsen Torstein Aune Brigitte Klüwer Kjersti Rydland Olav Hungnes
More informationInfluenza Weekly Surveillance Bulletin
Influenza Weekly Surveillance Bulletin Northern Ireland, Week 6 (8 February 216 14 February 216) Summary In Northern Ireland, as of week 6 215, the 215/16 influenza season has seen low community influenza
More informationInfluenza Weekly Surveillance Bulletin
Influenza Weekly Surveillance Bulletin Northern Ireland, Week 16 (18 April 216 24 April 216) Summary In Northern Ireland, as of week 16 216, the 215/16 influenza season has seen low community influenza
More informationAustralian National Influenza Centres Activity
Australian National Influenza Centres Activity 2011-12 Professor Dominic Dwyer Medical Virologist Director ICPMR and WHO NIC Westmead Hospital Sydney, NSW 2145, Australia dominic.dwyer@sydney.edu.au WHO
More informationIncorporating virologic data into seasonal and pandemic influenza vaccines
Incorporating virologic data into seasonal and pandemic influenza vaccines Kanta Subbarao WHO Collaborating Centre for Reference and Research on Influenza & Department of Microbiology and Immunology, University
More informationReagents for the Typing of Human Influenza Isolates 2011
Reagents for the Typing of Human Influenza Isolates 2011 This product was developed by the Victorian Infectious Diseases Reference Laboratory (VIDRL) in its capacity as a WHO Collaborating Centre for Reference
More informationNORWAY: NATIONAL INFLUENZA CENTRE:
REPORT 2018 NORWAY: NATIONAL INFLUENZA CENTRE: prepared for the WHO Informal Meeting on Strain Composition for Inactivated Influenza Vaccines for use in the Season 2018-19 Geneva, February 2018 NORWAY:
More informationChinese Influenza Weekly Report
Chinese Influenza Weekly Report (All data are preliminary and may change as more reports are received) Summary During week 23, influenza activity level in mainland China was very low, only a few influenza
More informationChinese Influenza Weekly Report
Chinese Influenza Weekly Report (All data are preliminary and may change as more reports are received) Summary During week 27, influenza activity level in mainland China was very low, only a few influenza
More informationInfluenza Activity in Indiana
Objectives of Influenza Surveillance Influenza Activity in Indiana 2014-2015 Reema Patel, MPH Respiratory Epidemiologist Epidemiology Resource Center Indiana State Department of Health Monitor influenza-like
More informationph1n1 H3N2: A Novel Influenza Virus Reassortment
ph1n1 H3N2: A Novel Influenza Virus Reassortment Jonathan Gubbay Medical Microbiologist Public Health Laboratory Public Health Ontario June 16, 2011 ph1n1 H3N2 Reassortment: Talk Overview Explain strain
More informationPublic Health Wales CDSC Weekly Influenza Surveillance Report Wednesday 21 st January 2015 (covering week )
The The Influenza B in certain countries8 Public Health Wales CDSC Weekly Influenza Surveillance Report Wednesday 21 st January 215 (covering week 3 215) Current level of activity: Low Trend: Decreased
More informationINFLUENZA WEEKLY UPDATE 2014/27: 30 June 6 July 2014
ILI per population INFLUENZA WEEKLY UPDATE 14/27: 3 June 6 July 14 The national influenza surveillance system in New Zealand is an essential public health component for assessing and implementing strategies
More informationManitoba Influenza Surveillance Report
Manitoba Influenza Surveillance Report 212/213 Season Summary: Week 47: Nov 18-24, 212 The influenza-like-illness rate was 4.8% with 5% of sentinel physician sites reporting. There was one case of influenza
More informationInfluenza Update N 159
Influenza Update N 159 10 May 2012 Summary The seasonal peak for influenza has passed in most countries in the temperate regions of the northern hemisphere. Different viruses have predominated in different
More informationINFLUENZA WEEKLY UPDATE 2014/25: June 2014
ILI per 1 population INFLUENZA WEEKLY UPDATE 14/25: 16 22 June 14 The national influenza surveillance system in New Zealand is an essential public health component for assessing and implementing strategies
More informationInfluenza Surveillance Report
Influenza Surveillance Report www.infectiousdisease.dhh.la.gov Week 5: 12/23/18-12/29/18 Influenza activity increased this week in Louisiana. Rhino/Enteroviruses, RSV, and Coronaviruses represent the majority
More informationHPS Monthly National Seasonal Respiratory Report
HPS Monthly National Seasonal Respiratory Report Week ending 18 March 218 week 11 1 Overall assessment In week 11, the overall assessment remains green (below baseline activity). GP consultation rate for
More informationvirus characterisation
SURVEILLANCE REPORT Influenza Influenza virus virus characterisation Summary Europe, July 2012 Summary Europe, July 2015 Summary Over the course of the 2014 15 influenza season, influenza A(H3N2), A(H1N1)pdm09
More informationThis product was developed by the Victorian Infectious Diseases Reference Laboratory (VIDRL) in its capacity as a WHO Collaborating Centre for
This product was developed by the Victorian Infectious Diseases Reference Laboratory (VIDRL) in its capacity as a WHO Collaborating Centre for Reference and Research on Influenza, with material provided
More informationTECHNICAL DOCUMENT Community Network of Reference Laboratories (CNRL) for Human Influenza in Europe. Influenza virus characterisation
Community Network of Reference Laboratories (CNRL) for Human Influenza in Europe Influenza virus characterisation Summary Europe, January 2010 A(H1N1pdm) viruses have continued to predominate. Surveillance
More informationManitoba Health, Healthy Living and Seniors (MHHLS) Week 9 (Feb.28 Mar.5, 2016) == Severe outcomes associated with. == Cases and cumulative incidence
Manitoba Health, Healthy Living and Seniors (MHHLS) Influenza Surveillance `Week 215 216 53: Dec 28, 214 Jan 3, 215 Week 9 (Feb.28 Mar.5, 216) Data extracted Mar. 11, 216 at 11: am Laboratory-confirmed
More information