Programme for Global Health and Vaccination Research - GLOBVAC. Kå rstein M å seide, programme coordinator

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1 Programme for Global Health and Vaccination Research - GLOBVAC Kå rstein M å seide, programme coordinator

2 The Research Council of Norway Adviser to the government on research- policy issues Finance and stimulate public and private R&D Create arenas for cooperation and knowledge distribution

3 The Council distributes about 30 % of public expenditures on R&D in Norway Public funding of R&D in Norway 42% Ministry of Education and Research The Research Council Other Ministries Higher education sector Institutes Industry

4 GLOBVAC Program for Global Health and Vaccination Research Background Global burden of disease (10 mill. children <5 years die each year) 10/90- gap i funding of health research Norway s international commitments: UN MDGs (4,5,6), EDCTP, Norwegian-Indian collaboration on vaccinat ion research, GAVI et c. Building Norwegian expertise is timely and in line with international efforts GLOBVAC Global Health (2004) and Vaccination Research (2006)

5 GLOBVAC Aim s and objectives Strengthen and expand research that can contribute to sustainable improvements in health in low- and middle- income countries developing knowledge and tools to combat the major disease burden in these countries developing and strengthening of sustainable Norwegian public and private research groups and institutions developing and strengthening of international collaboration developing and strengthening of partnerships with research groups and institutions in low- and middleincome countries to secure capacity building GLOBVAC programme plan, April 2007, globvac

6 GLOBVAC Priority research areas Poverty- related infectious diseases Global health research: New and existing methods for prevention, diagnosis, treatment, care Health policy and systems research: Equity, accessibility, affordability Vaccination research: Epidemiology, diagnostic tools, vaccine R&D, im m une correlates, outcome ( efficacy, effectiveness, surveillance), availability and coverage Stimulation of technology transfer to low- and middle- income countries

7 GLOBVAC Budget and projects

8 GLOBVAC projects Global health research 17 PROJECTS, 90 mill. NOK Respiratory Development of a subunit vaccine for prevention of reactivation of tuberculosis Improving diagnosis, treatment and control of childhood tuberculosis The dual role of macrophages in mycobacterial- and HIV disease: host cell and generator of protective mediators with therapeutic potential Tuberculosis in the 21st century; an emerging pandemic Indoor air pollution. A neglected poverty related cause of global ill health. Implications for health and society of promoting clean fuels in China Norwegian University of Science and Technology (NTNU) GLOBVAC project database, globvac

9 GLOBVAC projects Global health research 17 PROJECTS, 90 mill. NOK (continued) STD Alternative treatment strategies in HIV infection - research platform with integrated biological and clinical objectives Searching for effective HIV-prevention and care in sub-saharan Africa: focusing on local contexts (2 project periods) Phase III double blind placebo-controlled trial of infant periexposure prophylaxis with 3TC to prevent HIV-1 transmission by breastfeeding HIV vulnerability and HIV prevention needs among men who have sex with men in Tanzania GLOBVAC project database, globvac

10 GLOBVAC projects Global health research 17 PROJECTS, 90 mill. NOK (continued) Other Accessibility to health services among people with disabilities in southern Africa Evaluation of the impact of the Integrated Management of Neonatal and Childhood Illness Strategy on Neonatal and Infant Mortality Focus on nutrition and child health: Intervention Studies in lowincome countries Pectin products from Malian medicinal plants, can they combat ailments related to the immune system? Right to health through litigation? Can court enforced health rights improve health policy and priority setting in poor countries? Strenghtening human resources for health. A study of health worker availability and performance in Tanzania Type 2 diabetes and lifestyle in ethnic minorities in Oslo, and in populations in Pakistan, Bangladesh and China SINTEF Norwegian Institute of Public Health Chr. Michelsen institute GLOBVAC project database, globvac

11 GLOBVAC projects Vaccination research 15 PROJECTS, 127 mill. NOK Respiratory 2nd generation Vaccibodies for infectious diseases Immunity towards mycobacteria - identification of avirulent vaccine strains and therapeutic targets Preparing for tuberculosis vaccine efficacy trials: Baseline epidemiology, improved diagnosis, markers of protection and phase I/II trials Norwegian University of Science and Technology (NTNU) Impact of a new and affordable conjugate meningococcal vaccine on carriage of serogroup A Neisseria meningitidis and disease transmission Norwegian Institute of Public Health The Immunogenicity and Protective Efficacy of Plant- Derived Influenza H5N1 Vaccine in Preclinical Models. GLOBVAC project database, globvac

12 GLOBVAC projects Vaccination research 15 PROJECTS, 127 mill. NOK (continued) STD Phase IIb-Test of Concept Clinical Trial of the Peptidebased HIV-1 Therapeutic Vaccine Candidate Vacc-4x Novel vaccine candidates and delivery systems for HIV and influenza Further developments of new immunogenic peptidebased HIV vaccines targeting dendrittic cells Bionor Immuno AS Enteric New rotavirus vaccines: targeting childhood morbidity and mortality in low- and middle-income countries in Central Asia Comparison of Safety and Immunogenicity of Refrigerator Stable and Frozen Formulation of 116E Live Attenuated Oral Rotavirus Vaccine Developing vaccines against diarrhea caused by Escherichia coli and Shigella Norwegian Institute of Public Health Norwegian Institute of Public Health GLOBVAC project database, globvac

13 GLOBVAC projects Vaccination research 15 PROJECTS, 127 mill. NOK (continued) Other Integrated health information systems for vaccination in developing countries LAYVAC: Lay health worker programmes for vaccine uptake in low and middle income countries: Developing a global knowledge-base Multi-disciplinary approach to Explaining Differential Immunization Coverage OMEVAC (Open Mobile Electronic Vaccine Trials), an interdisciplinary project to improve quality of vaccine trials in low-resource settings SINTEF GLOBVAC project database, globvac

14 GLOBVAC strategic collaboration Norwegian- Indian collaboration on vaccination research Aim Strengthen vaccine related R&D Foster innovation, problem solving and global commitment Explore potential synergy effects Platforms for private sector Activities Joint calls for proposals Conferences and activities of mutual interest 4 PROJECTS, 40 mill. NOK Comparison of Safety and Immunogenicity of Refrigerator Stable and Frozen Formulation of 116E Live Attenuated Oral Rotavirus Vaccine Developing vaccines against diarrhea caused by Escherichia coli and Shigella Novel vaccine candidates and delivery systems for HIV and influenza Preparing for tuberculosis vaccine efficacy trials: Baseline epidemiology, improved diagnosis, markers of protection and phase I/II trials Norwegian Institute of Public Health

15 GLOBVAC strategic collaboration European and Developing Countries Clinical Trials Partnership (EDCTP) Mission: To accelerate the development of new or improved drugs and vaccines against HIV, TB, and malaria, with focus on phase II and III clinical trials and on sub- Saharan Africa GLOBVAC contributions Representative to European Network of National Programmes (ENNP) 50 mill. NOK co-funding available for EDCTP calls on vaccination in 2007/ PROJECT, 15 mill. NOK Phase III double blind placebo-controlled trial of infant periexposure prophylaxis with 3TC to prevent HIV-1 transmission by breastfeeding

16 Aim Promote high quality research and training aiming at improving health and health care for marginalized population groups in low- and middle-income countries Current activities Establishment of a national research school in global health Organizing conferences Advocacy for improved funding and better co-ordination of global health research Advocacy for improved funding for implementation/intervention research

17 GLOBVAC Challenges Build and strengthen research capacity in global health and vaccination research in Norway Support high quality research Long term research collaboration with low- and middle- income countries Global health research: Increased and sustained funding Vaccination research: Mobilize research groups and institutions

18 GLOBVAC calls for proposals: Applications and allocations GLOBAL HEALTH VACCINATION Amount (mill. NOK) Number Amount (mill. NOK) Number YEAR YEAR Amount applied for (mill. NOK) Allocated funding (mill. NOK) # proposals received

19 GLOBVAC Types of support Researcher projects Biotech/ industry ( user- driven innovation projects) Career development for young scientists Center support (research institution- based strategic project) Project establishment support Conferences (support for events)

20 GLOBVAC Who can apply? Eligible applicants are public and private Norwegian institutions. The programme will support researchers working on global health and vaccination research and with the potential of being in the international forefront in this field. Research collaboration between Norway and India is part of this programme, and joint calls will follow special guidelines....developing and strengthening of international collaboration...developing and strengthening of partnerships with research groups and institutions in low- and middle-income countries to secure capacity building

21 GLOBVAC Conferences Nov. 2006: Norwegian research for the Millennium Developm ent Goals 4 and Oct. 2007: Engaging in global health research: Building capacity in Norway and in low- and middle- income countries 5-6 March 2008: Building partnerships in vaccination research Oct. 2008: Research for im proved im plem entation

22 GLOBVAC Programme board Ann-Mari Svennerholm, Chair University of Gothenburg Marianne Bergsaker The Norwegian Institute of Public Health Finn Trunk Black Skejby Hospital, Aarhus Paul Fife The Norwegian Agency for Development Cooperation (Norad) Tore Godal (observer) Office of the Prime Minister Geir Gogstad Rikshospitalet-Radiumhospitalet Medical Center Edward B. Messelt Mona Møller Axial Biotech Consulting Helle Samuelsen University of Copenhagen Elisabete Weiderpass Vainio Cancer Registry of Norway Birgitta Åsjø Helga Fogstad (deputy) The Norwegian Agency for Development Cooperation (Norad) Secretariat Kårstein Måseide programme coordinator Mona Renolen executive officer

23 globvac

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