Influenza Vaccines: Giving the Right Dose at the Right Time. Agenda
|
|
- Wesley Carson
- 6 years ago
- Views:
Transcription
1 Influenza Vaccines: Giving the Right Dose at the Right Time Wednesday, December 9, :00 PM ET Agenda Agenda Welcome and Introduction William Schaffner, MD, NFID Medical Director Influenza Vaccines: Giving the Right Dose at the Right Time Kathleen M. Neuzil, MD, MPH, Professor, Department of Medicine, Director, Center for Vaccine Development, University of Maryland School of Medicine Open Discussion/Questions and Comments 1
2 General Information Please note that today s webinar is being recorded All phone lines will be placed on mute throughout the program To hear audio: Computer: Follow directions Phone: ; Access Code After the presentations, there will be a Question and Answer period Use the Chat box on the lower left side of your screen to type your question At the end of the webinar, participants will be directed to an online evaluation CME Credit/Webinar Evaluation The National Foundation for Infectious Diseases (NFID) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. NFID designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit TM. Online evaluation and post-test will be available following the webinar at: Certificate will be available for print or download following successful completion of online evaluation and post-test. 2
3 Disclosures Marla Dalton (NFID staff, content reviewer) owns stock, stock options, or bonds from Merck & Co., Inc. William Schaffner (NFID medical director, content reviewer) served as an advisor or consultant for Merck & Co., Inc., Pfizer Inc., and Novavax; and served as a speaker or member of a speaker s bureau for Merck & Co., Inc. All other faculty, activity planners/reviewers, and staff for this activity have no relevant financial relationships to disclose Learning Objectives At the conclusion of this webinar, participants will be able to: Evaluate the characteristics of influenza vaccines and the appropriateness of each for different populations Develop strategies to increase immunization coverage in clinical practice Provide patient education on the prevention and control of influenza 3
4 About NFID Non-profit 501(c)(3) organization dedicated to educating the public and healthcare professionals about causes, treatment, and prevention of infectious diseases across the lifespan Reaches consumers, health professionals, and media through: Coalition-building activities Public and professional educational program Scientific meetings, research, and training Longstanding partnerships to facilitate rapid program initiation and increase programming impact Flexible and nimble organization Influenza Vaccine: New Options, New Opportunities Kathleen M. Neuzil, MD, MPH Professor, Department of Medicine Director, Center for Vaccine Development University of Maryland School of Medicine December 9,
5 Influenza Vaccine: New Options, New Opportunities To review the characteristics of currently available influenza vaccines To provide the evidence and rationale for the current influenza vaccine recommendations To describe future directions for influenza vaccines and vaccination strategies Influenza A Virus Hemagglutinin (H) 17 subtypes (attachment, penetration) Neuraminidase (N) 10 subtypes (release) 8 viral genes (assembly, replication) M2 Protein (replication) Source: AS Fauci 5/13/2013 5
6 Reassortment of Influenza A Viruses Alpha 2,3 receptors in respiratory tract Alpha 2,6 receptors Non-human virus Alpha 2,6 & Alpha 2,3 receptors in respiratory tract Page 11 Reassortant virus 5/13/2013 Human Influenza - Clinical Acute febrile respiratory illness - Many influenza-like illness definitions - Fever or feverish - Cough and/or sore throat or other manifestations (otitis) - More serious pulmonary manifestations - Primary or secondary pneumonia, croup, bronchiolitis - Non-specific febrile illness - Extra-pulmonary manifestations - Neurologic Encephalitis, seizures - Myositis - Cardiac You will find what you look for! Page 12 5/13/2013 6
7 38-yo Fever, cough, myalgias 56 yo s/p BMT - primary influenza pneumonia 73 yo woman with primary influenza pneumonia 43 yo man S. aureus pneumonia Influenza Burden in US Infection rates are highest among children, with complications, hospitalizations, and deaths from seasonal influenza being greatest among persons aged 65 years, children aged <2 years, and persons of any age who have medical conditions that confer increased risk for complications from influenza Highly variable from year-to-year From through , deaths ranged from 3,000 to 49,000 annually From through , the estimated annual overall number of influenza-associated hospitalizations in the United States ranged from approximately 55,000 to 431,000 per annual epidemic (mean: 226,000) 7
8 8
9 Influenza: An epidemic respiratory disease associated with excess deaths Selwyn Collins, USA 9
10 10
11 Influenza Vaccine Recommendations, US, 2015 Routine annual influenza vaccination of all persons aged 6 months continues to be recommended No preferential recommendation is made for one influenza vaccine product over another for persons for whom more than one product is otherwise appropriate MMWR. August 7, Vol 64. No However it is most important for people at increased risk of complications and for those who care for them Highest risk Children 6 through 59 months Adults 65 years and over Persons of all ages with underlying conditions that predispose them to more severe disease Including pregnant women Healthcare workers and persons in close contact with any of the above 11
12 73-year-old retired professor presents for his annual influenza vaccine. He has heard that the flu shot may not work in older people. He knows that his grandson just received a nasal spray vaccine. After discussion and providing education to your patient, what influenza vaccine would you administer? Page 23 January 10, 2014 Influenza Vaccines, US, Type of Vaccine Trade Name Manufacturer Age Indications Route IIV3: Inactivated influenza vaccine; Trivalent Afluria Flucelvax CSL Limited Novartis Vaccines 9 years 18 years IM and needle-free jet injector IM Note: One vaccine is produced in cell culture; this is referred to as cciiv IIV4: Inactivated influenza vaccine; Quadrivalent Fluvirin Novartis Vaccines 4 years IM Fluzone Sanofi Pasteur 6 months IM Fluzone High-Dose (60mcg HA/strain/dose Sanofi Pasteur 65 years IM Fluarix Quadrivalent GlaxoSmithKline 3 years IM Fluzone Quadrivalent Sanofi Pasteur 6 months IM FluLaval ID Biomedical 3 years IM RIV3: Recombinant HA; Trivalent Fluzone Intradermal (9mcg HA/strain/dose) FluBlok (45mcg HA/strain/dose) Sanofi Pasteur 18 through 64 years Intradermal Protein Sciences > 18 years IM LAIV4: Live attenuated influenza vaccine; Quadrivalent FluMist Quadrivalent MedImmune 2 through 49 years Intranasal 12
13 Live Attenuated Standard Inactiv High dose Inactivated Recomb Inactiv. intradermal Route Intranasal IM IM IM ID Frequency Annual Annual Annual Annual Annual Approved risk groups and ages Healthy, 2 thru 49 yrs All, 6 months All,>65 years All, > 18 years All, 18 thru 64 years HA (mcg/strain) Common side effects Pregnant women? Use in close contacts of high risk/pregnant/ Immune compromised Sore throat nasal congest. Injection site rxn More injection site rxn Injection site rxns Erythema at inject site NO YES YES YES YES YES* YES YES YES YES * Except persons requiring a protected environment (e.g., hematopoietic stem cell transplant recipient). Influenza Vaccines for Older Persons While post-licensure observational studies are important tools for monitoring vaccine effectiveness, such studies relating to influenza vaccine in the elderly are particularly challenging to perform and interpret Confounding Inadequate adjustment for medical co-morbidities can affect effectiveness estimates Difficult to adjust for other characteristics of vaccinees versus non-vaccinees (vaccine-seeking behavior) Non-specific and limited outcome measures Influenza causes a range of non-specific clinical syndromes Many of the early observational studies did not include laboratory-confirmed outcomes Jackson LA, Jackson ML, Nelson JC, Neuzil KM, Weiss NS. Evidence of bias in estimates of influenza vaccine effectiveness in seniors. Int J Epidemiol 2006; 35: /13/
14 Re-analysis of randomized, controlled trial of influenza vaccine in persons 60 years and older Mortality benefits of influenza vaccination in elderly people. The Lancet. August 2008, Volume 8, page /13/
15 B. Flannery ACIP June 24, 2015 B. Flannery ACIP June 24,
16 High-Dose Influenza Vaccine in Adults 65 Years and Over A multicenter, randomized, double-blind controlled study was conducted to compare HD vaccine (which contains 60 mcg of HA per strain) with the licensed standard-dose (SD) vaccine (which contains 15 mcg HA per strain) in adults 65 years of age HD vaccine was administered to 2575 subjects, and SD vaccine was administered to 1262 subjects The immunogenicity of HD vaccine was assessed in terms of rates of seroconversion and ratio of GMTs for each virus strain, relative to the values obtained for the SD vaccine 5/13/2013 Falsey et al. JID 2009:200 (15 July). 5/13/
17 17
18 Randomized, Controlled Trial of High- Dose vs. Standard Dose Influenza Vaccine Presented at ACIP, October, Randomized, Controlled Trial of High-Dose vs. Standard Dose IIV Presented at ACIP, October,
19 Presented at ACIP, October,
20 20
21 Used data from the FIM12 head-to-head randomized controlled trial High dose cost US $31.82, standard dose $12.04 Incremental cost-effectiveness ratios (ICERs) Per-participant Costs by Resource Item (in US$ per vaccine) 21
22 Adjuvanted Influenza Vaccines Widely studied with pre-pandemic vaccines to enhance immunogenicity Increased cross-protection Enhanced antibody and cellular responses Seasonal MF-59 adjuvanted (FluAd) approved for 65+ in Europe since 1997 MF-59 and ASO3 used in monovalent vaccines during the pandemic Generally safe (Some countries have identified possible link between ASO3 and narcolepsy) Higher regulatory hurdles in the US Page 43 5/13/
23 Recombinant Influenza Vaccines Benefits (compared with current egg-based): Production not reliant on or limited by production in eggs Potentially shorter cycle from strain identification to vaccine availability Potential for closer match with circulating strains Challenges Market share and price 23
24 Many Unanswered Questions What is the effect of priming (original antigenic sin?) on future vaccine responses? What is the effect of vaccination over multiple years? What is the duration of vaccine protection? Will effects differ by type of vaccine (nonreplicating vs live attenuated?) How do we best measure indirect protection in different settings/environments? What are we looking for in a better vaccine? 24
25 What are we looking for in a better vaccine? More effective at preventing influenza illness? What are we looking for in a better vaccine? More effective at preventing influenza illness? More effective at preventing severe infection? 25
26 What are we looking for in a better vaccine? More effective at preventing influenza illness? More effective at preventing severe infection? More broadly protective? What are we looking for in a better vaccine? More effective at preventing influenza illness? More effective at preventing severe infection? More broadly protective? Longer lasting immunity? 26
27 What are we looking for in a better vaccine? More effective at preventing influenza illness? More effective at preventing severe infection? More broadly protective? Longer lasting immunity? Safer? What are we looking for in a better vaccine? More effective at preventing influenza illness? More effective at preventing severe infection? More broadly protective? Longer lasting immunity? Safer? Easier, more efficient manufacturing? 27
28 What are we looking for in a better vaccine? More effective at preventing influenza illness? More effective at preventing severe infection? More broadly protective? Longer lasting immunity? Safer? Easier, more efficient manufacturing? How much are we willing to pay for these improvements? 12/9/2015 Page 56 28
29 > 65 years: 66.7 % 29
30 Influenza Common respiratory illness accounting for substantial morbidity, mortality, lost productivity annually Influenza vaccines are safe and effective how effective varies by year and influenced by virus, vaccine, host Vaccination schedules will become more nuanced in regard to the use of specific vaccines for specific age and risk groups 30
31 Questions & Answers CME Credit/Webinar Evaluation The National Foundation for Infectious Diseases (NFID) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education (CME) for physicians. NFID designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit TM. Online evaluation and post-test will be available following the webinar at: Certificate will be available for print or download following successful completion of online evaluation and post-test 31
32 Join us for upcoming NFID CME Webinars Vaccination for Healthcare Professionals Wednesday, January 13, :00 PM ET Register: Subscribe for future updates: 32
The Expanding Rotavirus Vaccine Landscape: Lessons learned from Influenza Vaccines
The Expanding Rotavirus Vaccine Landscape: Lessons learned from Influenza Vaccines Kathleen Neuzil, MD, MPH Director, Center for Vaccine Development University of Maryland School of Medicine September
More informationWhat s New in Flu? An Update on Influenza Prevention and Treatment
What s New in Flu? An Update on Influenza Prevention and Treatment Kathryn M. Edwards MD Sarah H. Sell and Cornelius Vanderbilt Professor of Pediatrics Vanderbilt University Nashville, TN, USA Disclosures
More informationIn Case of Technical Difficulties
In Case of Technical Difficulties If you hear an echo: -- Make sure you are only logged in once on your computer -- Select one form of audio only (either computer speakers or telephone connection) If the
More informationDisclosures. No support One off-label recommendation
Seasonal Influenza John B. Murphy, MD Professor of Medicine and Family Medicine Warren Alpert Medical School of Brown University Executive Vice President for Physician Affairs, Lifespan 8/21/14 Disclosures
More informationTalkin Flu Mid-America Immunization Coalition August 18, William Atkinson, MD, MPH Immunization Action Coalition
Talkin Flu Mid-America Immunization Coalition August 18, 2016 William Atkinson, MD, MPH Immunization Action Coalition Disclosures William Atkinson has worked as a consultant to Merck and as a speaker for
More informationInfluenza: Virus, vaccines and vaccination strategies
Influenza: Virus, vaccines and vaccination strategies Kathleen Neuzil, MD, MPH Director, Vaccine Access and Delivery Global Program Clinical Professor, University of Washington May 20, 2014 Objectives
More informationRespiratory Syncytial Virus (RSV) in Older Adults: A Hidden Annual Epidemic. Webinar Agenda
Respiratory Syncytial Virus (RSV) in Older Adults: A Hidden Annual Epidemic Wednesday, November 2, 2016 12:00 PM ET Webinar Agenda Agenda Welcome and Introductions William Schaffner, MD, NFID Medical Director
More informationInfluenza Update. Lisa Grohskopf, MD, MPH Influenza Division, CDC. NAICP Call 6 October 2015
Influenza Update Lisa Grohskopf, MD, MPH Influenza Division, CDC NAICP Call 6 October 2015 National Center for Immunization and Respiratory Diseases Influenza Division Overview Surveillance update ACIP
More informationThese slides are the property of the presenter. Do not duplicate without express written consent.
Cancer Survivorship Protecting Against Vaccine Preventable Diseases Heidi Loynes BSN, RN Immunization Nurse Educator Michigan Department of health and Human Services (MDHHS) loynesh@michigan.gov Are Vaccine-Preventable
More informationKenneth McCall, BSPharm, PharmD Associate Professor UNE President Maine Pharmacy Association
Kenneth McCall, BSPharm, PharmD Associate Professor UNE President Maine Pharmacy Association Objectives Discuss the gap between current rates and Healthy People 2020 goals for vaccinations. Categorize
More informationFlu Vaccine Access Via Pharmacy Vaccine Network
Re: Flu Vaccine Access Via Pharmacy Vaccine Network Effective 9/15/2016, IEHP Medi-Cal and Medicare DualChoice Cal MediConnect (IEHP Direct) Members who are over 18 years old may obtain Flu Vaccines through
More informationMDPH Influenza Update
Massachusetts Department of Public Health Bureau of Infectious Disease and Laboratory Sciences MDPH Influenza Update 9-27-2017 Susan M. Lett, MD, MPH Medical Director, Immunization Program MA Department
More informationAddressing the Challenges of Serogroup B Meningococcal Disease Outbreaks on Campuses
Addressing the Challenges of Serogroup B Meningococcal Disease Outbreaks on Campuses Monday, November 17, 2014 12:00 PM ET This activity is supported by an unrestricted educational grant from Novartis
More informationIn Case of Technical Difficulties
Interview with Stanley A. Plotkin, MD: Greatest Vaccinology Discoveries of the Last Decade and Future Predictions Wednesday, February 15, 2017 12:00 PM ET In Case of Technical Difficulties If you hear
More informationHemagglutinin Neuraminidase
Evolving Vaccine Guidance: Influenza, Meningococcal & HPV Vaccines H. Cody Meissner, M.D. Professor of Pediatrics Tufts University School of Medicine Maine Chapter AAP Bar Harbor, Maine October 16, 2016
More informationInfluenza Virus. Influenza A virus. Influenza B virus. Influenza C virus
Outline Influenza Virus Population Data Vaccination Rates 2010-11 Influenza Vaccines Live Attenuated Influenza Vaccine (LAIV) High-Dose Trivalent Inactivated Vaccine (HD TIV) Influenza Virus Influenza
More informationKenneth McCall, BSPharm, PharmD Associate Professor UNE
Kenneth McCall, BSPharm, PharmD Associate Professor UNE Objectives Discuss the gap between current rates and Healthy People 2020 goals for vaccinations. Categorize each of the CDC recommended flu vaccines
More informationCONTAGIOUS COMMENTS Department of Epidemiology
VOLUME XXXIII NUMBER 4 September 2018 CONTAGIOUS COMMENTS Department of Epidemiology Influenza Vaccination Suchitra Rao, MBBS and Jason Child, PharmD New influenza vaccines have arrived. It is important
More informationNavigating Options for Influenza Immunization, What a difference a decade makes 2004
Navigating Options for Influenza Immunization, 2013-2014 What a difference a decade makes 2004 Disclosures No financial conflicts of interest May discuss off-label use of influenza vaccines during presentation
More informationInfluenza Clinical Bulletin # 3: October 8, 2009 Vaccination Guidelines for Patients for Influenza
The purpose of this document is to provide NYP providers with the most current recommendations regarding influenza vaccination for their patients. It is important to recognize that guidance reflects optimal
More informationUpdate on Influenza Vaccines, the Influenza Season, and the Impact of Vaccination on Influenza Disease Burden
National Center for Immunization & Respiratory Diseases Update on Influenza Vaccines, the 2017 2018 Influenza Season, and the Impact of Vaccination on Influenza Disease Burden Melissa Rolfes, PhD MPH Epidemiologist
More informationNeedle Facts: Immunization Update Mirada Wilhelm, PharmD Clinical Associate Professor SIUE School of Pharmacy
Needle Facts: Immunization Update 2015 Mirada Wilhelm, PharmD Clinical Associate Professor SIUE School of Pharmacy Objectives Pharmacists At the conclusion of this program, the pharmacist will be able
More informationIn Case of Technical Difficulties
The Role of Healthcare Professionals in Protecting Older Adults against Influenza Wednesday, September 6, 2017 12:00 PM ET In Case of Technical Difficulties If you hear an echo: Make sure you are only
More informationInfluenza Prevention Update
Influenza Prevention Update Dean A. Blumberg, MD, FAAP Disclosure speakers bureau: sanofi pasteur, Merck Discussion off label use of FDA approved vaccines Influenza Prevention Update Seasonal influenza
More information10/6/2014. INFLUENZA: Why Should We Take The Vaccine? OUTLINE INFLUNZA VIRUS INFLUENZA VIRUS INFLUENZA VIRUS
INFLUENZA: Why Should We Take The Vaccine? Baptist Hospital Baptist Children s Hospital Doctors Hospital J. Milton Gaviria, MD, FACP October 17, 2014 Homestead Hospital Mariners Hospital Baptist Cardiac
More informationMaking Life Better UNIVERSITY OF SOUTH FLORIDA
Making Life Better UNIVERSITY OF SOUTH FLORIDA MCOL UNIV Making Life Better CO UN Disclosures I have no financial, personal, or familial associations to disclose What is a Vaccine? Agent stimulates the
More information9/11/2018. Influenza and Influenza Vaccines. Influenza. Influenza Virus. Highly infectious viral illness. First pandemic in 1580
Centers for Disease Control and Prevention National Center for Immunization and Respiratory Diseases Influenza and Influenza Vaccines September 2018 Photographs and images included in this presentation
More informationImmunizations: An Overview. Sutter Health May 9, 2017 John Apostolo, PharmD, MBA Heidi Rens, PharmD
Immunizations: An Overview Sutter Health May 9, 2017 John Apostolo, PharmD, MBA Heidi Rens, PharmD Sutter Health: System Overview 2 Agenda Sutter Health Overview Sutter Health Vaccine overview Clinical
More informationFlu Vaccines for
This Clinical Resource gives subscribers additional insight related to the Recommendations published in October 2018 ~ Resource #341001 Flu Vaccines for 2018-2019 CDC has released recommendations for influenza
More informationImmunization Update Tamara Sheffield, MD, MPA, MPH
Immunization Update 2015 Tamara Sheffield, MD, MPA, MPH Disclosure I do not have any relevant financial relationships with any commercial interests I am a Medical Director employed by Intermountain Healthcare
More informationNational Immunization Update
National Immunization Update H. Cody Meissner, M.D. Professor of Pediatrics Tufts Medical Center Boston, MA October 18, 2018 23 rd MIAP Immunization Conference Framingham, MA Disclaimers/Disclosure I have
More informationNational Immunization Update
National Immunization Update H. Cody Meissner, M.D. Professor of Pediatrics Tufts Medical Center Boston, MA October 18, 2018 23 rd MIAP Immunization Conference Framingham, MA Disclaimers/Disclosure I have
More informationFDA Approved Recombinant Hemagglutinin Influenza Vaccine Protects Against Drift Influenza Viruses
FDA Approved Recombinant Hemagglutinin Influenza Vaccine Protects Against Drift Influenza Viruses 2 nd International conference on Flu October 31- November 02, 2016 San Francisco, California, USA Protein
More informationUpdate on Adult Immunization
Update on Adult Immunization Paul J. Carson, MD, FACP Sanford Health, Infectious Disease NDSU Master of Public Health Program UND School of Medicine and Health Sciences When meditating over a disease,
More informationImmunization Update 2016 Clinical Learning Day. Tamara Sheffield, MD, MPA, MPH
Immunization Update 2016 Clinical Learning Day Tamara Sheffield, MD, MPA, MPH Disclosure I do not have any relevant financial relationships with any commercial interests I am a Medical Director employed
More informationIn Case of Technical Difficulties
Maternal Immunization: Protecting Mother and Baby Thursday, August 10, 2017 12:00 PM ET In Case of Technical Difficulties If you hear an echo: Make sure you are only logged in once on your computer Select
More informationImmunization Update. William Atkinson, MD, MPH. Immunization Action Coalition
Immunization Update William Atkinson, MD, MPH Immunization Action Coalition Coordinated School Health Conference Lake Ozark, Missouri December 3, 2016 1 Disclosures William Atkinson has no financial relationships
More informationImmunization Update: What s New in 2013? Thursday, August 15, :30 a.m. 12:30 p.m.
Immunization Update: What s New in 2013? Thursday, August 15, 2013 11:30 a.m. 12:30 p.m. Presented by: Lynn Trefren, RN Nurse Manager, Tri-County Health Department Deb Zambrano, PHNC Vaccines for Children
More informationACCREDITATION Pharmacy
FACULTY Michael D. Hogue, PharmD, FAPhA, FNAP Associate Dean, Center for Faith and Health Samford University College of Health Sciences Professor, Pharmacy Samford University McWhorter School of Pharmacy
More information9/12/2018. Influenza and Influenza Vaccines. Influenza. Influenza Virus. Highly infectious viral illness. First pandemic in 1580
Centers for Disease Control and Prevention National Center for Immunization and Respiratory Diseases Influenza and Influenza Vaccines Adult Track Photographs and images included in this presentation are
More informationIn Case of Technical Difficulties
Addressing Challenges in Adult Vaccine Financing Thursday, June 8, 2017 12:00 PM ET In Case of Technical Difficulties If you hear an echo: Make sure you are only logged in once on your computer Select
More informationNothing to disclose. Influenza Update. Influenza Biology. Influenza Biology. Influenza A 12/15/2014
Influenza Update Nothing to disclose. Lisa Winston, MD UCSF / San Francisco General Hospital Divisions of Infectious Diseases and Hospital Medicine Influenza Biology Influenza Biology Influenza viruses
More informationInfluenza. Alan P. Agins, Ph.D Objectives. Influenza Update: Influenza. Disclosures. Influenza Virus.
Influenza Update: 2016 Alan P. Agins, Ph.D. President: PRN Associates, Ltd Continuing Medical Education Tucson, AZ Objectives Understand how antigenic drift and antigenic shift are related to epidemics,
More informationInfluenza vaccines. Cheryl Cohen
Influenza vaccines Cheryl Cohen cherylc@nicd.ac.za Overview Burden of influenza and risk groups Clinical presentation, diagnosis and treatment Influenza the virus Currently available influenza vaccines
More informationTransforming The Approach to Vaccines and Protein- Based Therapeutics. Alain Doucet, Ph.D. Manager, Process Development, Medicago
Transforming The Approach to Vaccines and Protein- Based Therapeutics Alain Doucet, Ph.D. Manager, Process Development, Medicago 2018-08-15 1 Medicago Overview 2 Novel Technologies 3 Robust Pipeline 2
More informationImmunization Update 2013 Across the Lifespan
Immunization Update 2013 Across the Lifespan Andrew Kroger M.D., M.P.H. Medical Officer, Centers for Disease Control and Prevention New York State Association of County Health Officials (NYSACHO) New York
More informationHealth Care Personnel Vaccination in the Long Term Care Setting
Health Care Personnel Vaccination in the Long Term Care Setting Jennifer Heath, DNP, MPH, RN Objectives Interpret current influenza recommendations as they pertain to health care personnel (HCP) in the
More informationAdult Immunization Update 2015
Adult Immunization Update 2015 Objectives Upon completion of this session, the pharmacist should be able to: Compare and contrast previous versions of the ACIP immunization schedules with the most recent
More informationSANOFI PASTEUR INFLUENZA VACCINES
SANOFI PASTEUR INFLUENZA VACCINES Dan DiVito Senior Director, Influenza Vaccines US Our Credo Sanofi Pasteur believes in a world in which no one suffers or dies from a vaccine-preventable disease. 2018
More informationImmunization Update 2013
Immunization Update 2013 Andrew Kroger M.D., M.P.H. Centers for Disease Control and Prevention American Academy of Pediatrics Connecticut Chapter December 3, 2013 National Center for Immunization & Respiratory
More informationPennsylvania Academy of Family Physicians Foundation & UPMC 43rd Refresher Course in Family Medicine CME Conference March 10 13, 2016
Pennsylvania Academy of Family Physicians Foundation & UPMC 43rd Refresher Course in Family Medicine CME Conference March 10 13, 2016 Disclosures: Immunizations Donald Middleton, MD & Richard Zimmerman,
More informationInfluenza: A recap of the season
Influenza: A recap of the 2012 2013 season March 22, 2013 Debra Blog MD, MPH Director Division of Epidemiology What are we going to talk about The 2012 13 Influenza Vaccine Influenza Activity and Surveillance
More informationInfluenza. Influenza vaccines (WHO position paper) Weekly Epid. Record (2005, 80: ) 287
Program Management 82_19 SAGE encouraged all countries to consider their preparedness for a potential influenza pandemic, recognizing that it would occur before strain-specific vaccine can be made in significant
More informationImmunization Update 2017 Peds Clinical Learning Day. Tamara Sheffield, MD, MPA, MPH
Immunization Update 2017 Peds Clinical Learning Day Tamara Sheffield, MD, MPA, MPH Highlighted Topics Influenza Vaccine Errors 2 Dose HPV Community protection Tdap in pregnancy Hepatitis B Meningococcal
More informationInfluenza Vaccines. Wilbur H. Chen, MD, MS Associate Professor of Medicine April 19, 2017 CVD
Influenza Vaccines Wilbur H. Chen, MD, MS Associate Professor of Medicine April 19, 2017 Overview 1) Biology & Epidemiology of Influenza (and other Respiratory Viruses) 2) Currently Approved Influenza
More informationIn Case of Technical Difficulties
Improving Healthcare Personnel Immunization Rates Thursday, April 5, 2018 12:00 PM ET In Case of Technical Difficulties If you hear an echo: Make sure you are only logged in once on your computer Select
More informationPREVENTIVE IMMUNIZATIONS. PREVENTIVE IMMUNIZATIONS These codes do not have a diagnosis code requirement for preventive benefits to apply.
An immunization that does not fall under one of the exclusions in the Certificate of Coverage is considered covered after the following conditions are satisfied: (1) FDA approval; (2) explicit ACIP recommendation
More informationDiclosures. Objectives 12/29/17
Kristy Brittain, PharmD, BCPS, CDE Associate Professor, MUSC College of Pharmacy Clinical Pharmacy Specialist, Medical University of SC Diclosures Kristy Brittain has no conflict of interest to report.
More informationPREVENTIVE IMMUNIZATIONS. PREVENTIVE IMMUNIZATIONS These codes do not have a diagnosis code requirement for preventive benefits to apply.
An immunization that does not fall under one of the exclusions in the Certificate of Coverage is considered covered after the following conditions are satisfied: (1) FDA approval; (2) explicit ACIP recommendation
More informationNeedle Facts: Immunization Update 2017
Needle Facts: Immunization Update 2017 Miranda Wilhelm, Pharm.D. Clinical Associate Professor Southern Illinois University Edwardsville (SIUE) School of Pharmacy Disclosure and Conflict of Interest Miranda
More informationKey Facts about Seasonal Flu Vaccine from the Centers for Disease Control and Prevention
Key Facts about Seasonal Flu Vaccine from the Centers for Disease Control and Prevention Why should people get vaccinated against the flu? Influenza is a serious disease that can lead to hospitalization
More informationMA Adult Immunization Coaltion Flu Update September 28, 2016
MA Adult Immunization Coaltion Flu Update September 28, 2016 Susan M. Lett, MD, MPH Medical Director, Immunization Program Division of Epidemiology and Immunization Massachusetts Department of Public Health
More informationOverview of seasonal Influenza Vaccines and Future Directions
Overview of seasonal Influenza Vaccines and Future Directions San Jose, Costa Rica January 2013 Joseph Bresee Epidemiology and Prevention Branch Influenza Division National Center for Immunization and
More informationNeedle Facts: Immunization Update 2016
Needle Facts: Immunization Update 2016 Miranda Wilhelm, Pharm.D. Clinical Associate Professor Southern Illinois University Edwardsville School of Pharmacy Disclosure / Conflict of Interest Miranda Wilhelm
More informationInfluenza Program 2018
Influenza Program 2018 Presented by Angela Newbound SA PHN Immunisation Hub Coordinator The Immunisation Hub thanks the Immunisation Section CDCB for preparing this presentation Objectives Better understanding
More informationImmunization Update 2017 Adult Clinical Learning Day. Tamara Sheffield, MD, MPA, MPH
Immunization Update 2017 Adult Clinical Learning Day Tamara Sheffield, MD, MPA, MPH Highlighted Topics Influenza Vaccine Errors 2 Dose HPV Community protection Tdap in pregnancy Meningococcal Future Recs
More informationHELP PREVENT THE FLU WITH FLUMIST QUADRIVALENT
HELP PREVENT THE FLU WITH FLUMIST QUADRIVALENT THE NEEDLE-FREE INTRANASAL QUADRIVALENT FLU VACCINE Inf luenza Vaccine Live, Attenuated, Intranasal TABLE OF CONTENTS 2 What is FluMist Quadrivalent? 3 How
More informationThe Virtual Immunization Communication (VIC) Network is a project of the National Public Health Information Coalition (NPHIC) and the California
The Virtual Immunization Communication (VIC) Network is a project of the National Public Health Information Coalition (NPHIC) and the California Immunization Coalition, funded through a cooperative agreement
More informationFear the flu not the flu shot. David Bronstein, M.D. Pediatric Infectious Disease
Fear the flu not the flu shot. David Bronstein, M.D. Pediatric Infectious Disease PICTURE OF SNAKES & SPIDERS GOES HERE Beliefs It s just the flu. Only old people need a flu shot. I can t get the flu
More informationDOC / FLU SHOT FOR SENIORS 2017 DOCUMENT
18 January, 2018 DOC / FLU SHOT FOR SENIORS 2017 DOCUMENT Document Filetype: PDF 358.27 KB 0 DOC / FLU SHOT FOR SENIORS 2017 DOCUMENT For more information on the flu vaccine go to the Better Health Channel.
More information#HowIRecommend Flu Vaccine: How to Make Recommendations that Matter to Patients
National Center for Immunization & Respiratory Diseases #HowIRecommend Flu Vaccine: How to Make Recommendations that Matter to Patients John Donovan, MPH Seasonal Flu Campaign Lead, NCIRD December 12,
More informationThe Advisory Committee on Immunization
Need-to-know information for the 2016-2017 flu season ACIP now advises against using the LAIV nasal spray. In addition, 2 new vaccines are available and 2 more may soon be approved. Doug Campos-Outcalt,
More informationHIV/AIDS: The forgotten epidemic? James G. Dobbins Ph.D.
HIV/AIDS: The forgotten epidemic? James G. Dobbins Ph.D. HIV/AIDS: The forgotten epidemic? James G Dobbins, PhD OK you know the drill... HIV/AIDS: The forgotten Epidemic? But first things first when
More informationPrevention and Treatment of Seasonal Influenza. What to expect. Objectives 11/5/14
Prevention and Treatment of Seasonal Influenza Jason M. Pogue, PharmD, BCPS-ID Clinical Pharmacist, Infectious Diseases Sinai-Grace Hospital; Detroit Medical Center 7 November 2014 What to expect http://www.michigan.gov/mdch
More informationStudy No.: Title: Rationale: Phase: Study Period: Study Design: Centers: Indication: Treatment: Objectives: Primary Outcome/Efficacy Variable:
The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.
More informationInfluenza in the pediatric population
Influenza in the pediatric population Annual attack rates 10%-40% in children Hospitalization Increased risk in children
More informationAndrew Kroger, MD, MPH National Center for Immunization and Respiratory Diseases MCH & Immunization Conference Anchorage, AK September 28, 2010
2010 Immunization Update Andrew Kroger, MD, MPH National Center for Immunization and Respiratory Diseases MCH & Immunization Conference Anchorage, AK September 28, 2010 Disclosures No financial conflict
More informationAcute respiratory illness This is a disease that typically affects the airways in the nose and throat (the upper respiratory tract).
Influenza glossary Adapted from the Centers for Disease Control and Prevention, US https://www.cdc.gov/flu/glossary/index.htm and the World Health Organization http://www.wpro.who.int/emerging_diseases/glossary_rev_sept28.pdf?ua=1
More informationFluzone High-Dose Vaccine and FIM12 Efficacy Trial Results
Fluzone High-Dose Vaccine and FIM12 Efficacy Trial Results Corey A. Robertson, MD, MPH Director, Scientific and Medical Affairs, Sanofi Pasteur 1 Older Adults Suffer Disproportionately from Influenza-related
More informationWEBINAR 1 CODING FOR FLUZONE VACCINATION CODING AND BILLING FOR VACCINATION WITH FLUZONE, INFLUENZA VACCINES CRACKING THE CODES: UPDATED for
UPDATED for 2016-2017 CRACKING THE CODES: CODING AND BILLING FOR VACCINATION WITH FLUZONE, INFLUENZA VACCINES Value transfers to licensed health care professionals by pharmaceutical companies may need
More informationNew Vaccine Schedules. Disclosure. Overview. Immunization Recommendations in Primary Care. Objectives Pharmacists. Objectives Pharmacy Technicians
Disclosure Immunization Recommendations in Primary Care I have nothing to disclose. Betsy Blake, PharmD, BCPS October 2017 Objectives Pharmacists Learning Objectives: At the completion of this activity,
More informationWhat if Sherlock Holmes had to prepare your facility for Influenza?
What if Sherlock Holmes had to prepare your facility for Influenza? Gregory Gahm, MD, MS, FACP Elizabeth Schulte Mullins, MSW, NHA - Program Specialist November 2, 2017 Employee-Owned Employee-Owned What
More informationUpdate on Adult Immunization Strategies: Understanding the Current Recommendations
Sunday CME Breakfast Update on Adult Immunization Strategies: Understanding the Current Recommendations Edward Dominguez, MD Medical Director, Organ Transplant Infectious Diseases Methodist Dallas Medical
More informationInfluenza Backgrounder
Influenza Backgrounder Influenza Overview Influenza causes an average of 36,000 deaths and 200,000 hospitalizations in the U.S. every year. 1,2 Combined with pneumonia, influenza is the seventh leading
More informationShould patients with diabetes receive an influenza vaccine yearly?
My Background Tomorrow s Prevention, Today Margaret Robinson, PharmD Virginia Commonwealth University Community Pharmacy Residency Program Hometown: New Kent, VA Virginia Tech Bachelors of Science, Human
More informationINFLUENZA VIRUS. INFLUENZA VIRUS CDC WEBSITE
INFLUENZA VIRUS INFLUENZA VIRUS CDC WEBSITE http://www.cdc.gov/ncidod/diseases/flu/fluinfo.htm 1 THE IMPACT OF INFLUENZA Deaths: PANDEMICS 1918-19 S p a n is h flu 5 0 0,0 0 0 U S 2 0,0 0 0,0 0 0 w o rld
More informationHot off the press, What s new for immunizations in 2017?
Hot off the press, What s new for immunizations in 2017? Jennifer Girotto, PharmD, BCPPS Faculty Disclosure Dr. Girotto has no actual or potential conflicts of interest associated with this presentation.
More informationInfluenza. Tim Uyeki MD, MPH, MPP, FAAP
Influenza Tim Uyeki MD, MPH, MPP, FAAP Influenza Division National Center for Immunization and Respiratory Diseases Coordinating Center for Infectious Diseases Centers for Disease Control and Prevention
More informationImmunization Update 2018
Immunization Update 2018 Keri Hurley-Kim, PharmD, MPH Assistant Professor, Department of Pharmacy Practice West Coast University School of Pharmacy Conflicts of Interest Keri Hurley-Kim declares no conflicts
More informationMedicago: transforming the approach to vaccines and protein-based therapeutics. Bruce D. Clark PhD President & CEO September 27, 2017
Medicago: transforming the approach to vaccines and protein-based therapeutics Bruce D. Clark PhD President & CEO September 27, 2017 Medicago Overview Focus Manufacturing technology Vaccine technology
More informationACIP Meeting June 22, 2016 Influenza Session: Key Points
Update: CDC s Advisory Committee on Immunization Practices (ACIP) voted in favor of an interim recommendation that live attenuated influenza vaccine (LAIV), also known as the nasal spray flu vaccine, should
More informationHIT ME WITH YOUR BEST SHOT: UPDATE ON IMMUNIZATIONS. Karen Hoang, PharmD Clinical Pharmacy Specialist, MTM Services UPMC Health Plan
HIT ME WITH YOUR BEST SHOT: UPDATE ON IMMUNIZATIONS Karen Hoang, PharmD Clinical Pharmacy Specialist, MTM Services UPMC Health Plan DISCLOSURES No financial or other conflicts to disclose LEARNING OBJECTIVES
More informationVaccine Preventable Diseases Among Adults
Vaccine Preventable Diseases Among Adults Stephanie Borchardt, MPH, PhD Wisconsin Immunization Program Division of Public Health Wisconsin Department of Health Services November 17, 2016 At a Glance Burden
More informationHuman Influenza. Dr. Sina Soleimani. Human Viral Vaccine Quality Control 89/2/29. November 2, 2011 HVVQC ١
Human Influenza Dr. Sina Soleimani Human Viral Vaccine Quality Control 89/2/29 November 2, 2011 HVVQC ١ Presentation outline 1. Introduction 2. Virology 3. Classification 4. Hosts 5. Antigenic Specifications
More informationCDC DIRECTOR JOINS NATION S TOP HEALTH EXPERTS TO URGE AMERICANS TO SEEK INFLUENZA AND PNEUMOCOCCAL VACCINATIONS THIS FALL AND WINTER
Contact: Jennifer Corrigan 732-382-8898 732-742-7148 (Cell phone) Victoria Amari 212-886-2248 718-413-6491 (Cell phone) CDC DIRECTOR JOINS NATION S TOP HEALTH EXPERTS TO URGE AMERICANS TO SEEK INFLUENZA
More informationTHIS ACTIVITY HAS EXPIRED. CME CREDIT IS NO LONGER AVAILABLE
THIS ACTIVITY HAS EXPIRED. CME CREDIT IS NO LONGER AVAILABLE The following content is provided for informational purposes only. PREVENTION AND CONTROL OF INFLUENZA Lisa McHugh, MPH Influenza can be a serious
More informationAdult Vaccines in 2018: Where do we start?
Adult Vaccines in 2018: Where do we start? Jeff Goad, Pharm.D., MPH, FAPhA, FISTM Professor and Chair, Department of Pharmacy Practice Chapman University School of Pharmacy Annual Meeting San Francisco
More informationInfluenza: Wrap- Up and Preview of the Upcoming Season. October 6, 2016 Anita Valiani, MPH
Influenza: 2015-2016 Wrap- Up and Preview of the Upcoming Season October 6, 2016 Anita Valiani, MPH Anita.valiani@dhhs.nc.gov NC SHARPPS Surveillance for Healthcare-Associated Infections and Resistant
More informationQuadrivalent Flu Vaccines: Four Means More Protection
Quadrivalent Flu Vaccines: Four Means More Protection By Keith Berman, MPH, MBA, and Luke Noll AHEAD OF EACH flu season, experts at the U.S. Food and Drug Administration (FDA) and the World Health Organization
More information