Biorisk Management = Assessment, Mitigation, Performance

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1 Session 2 Page 1 of 57 Biorisk Management = Assessment, Mitigation, Performance April 2012

2 Group Exercise 1, Step 1 Page 2 of 57 Consider this scenario: A two-year-old child is left alone in a kitchen while there is boiling water on the stove. Take 10 min to answer the following questions: What could go wrong? List all the possibilities Choose the single most important risk for this scenario Identify the hazard for that risk Report out to the class

3 Page 3 of 57 What is a hazard?

4 Hazard Page 4 of 57 Hazard is a source or object that can cause harm Hazard is not a risk without a specific environment or situation

5 Page 5 of 57 What affects whether or not an incident may occur? How likely is an incident?

6 Page 6 of 57 How severe could an incident be? What affects the consequences of the incident?

7 Page 7 of 57 What is risk?

8 Risk Page 8 of 57 Risk is the likelihood of an event with a hazard that has consequences

9 Risk Page 9 of 57 Time Likelihood X Incident Consequences Factors that affect whether or not the incident happens Factors that affect the severity of the incident

10 Small Group Exercise 1, Step 2 Page 10 of 57 Consider again the two-year-old in the kitchen scenario: Risk: child being burned by the boiling water Hazard: pot of boiling water on the stove Take 15 min to: Identify the factors that influence the likelihood and consequences of the risk; use post-it notes for each factor Evaluate the risk (low, moderate, high) Report your results to the class

11 Page 11 of 57 What would be different if the risk were the child being injured by an older brother, whose toy had just been broken by the two-year-old? What is the hazard (threat) now?

12 Page 12 of 57 What is the difference between a hazard and a threat?

13 Hazard, Threat, and Risk Page 13 of 57 A hazard is a source or object that can cause harm In security terms, a threat is associated with a person who has intent to cause harm to other people, animals, or the institution A risk can be based on either a hazard, or a hazard and a threat

14 Page 14 of 57 How can we define risk, likelihood, and consequences?

15 Risk, Likelihood, and Consequences Page 15 of 57 Risk is the likelihood of an event with a hazard (or a hazard and threat) that has consequences Likelihood is the probability an event occurring Consequences is the severity of an event

16 Page 16 of 57 How can we define risk as an equation?

17 The Risk Equation Page 17 of 57 R = f (L, C)

18 Risk Graph I Page 18 of 57 Very High Likelihood Low Moderate High Very Low Consequences

19 Risk Graph II Page 19 of 57 Large amount of boiling water on front of stove, step stool next to stove, child not restrained Very High Likelihood Low Moderate High Very Low Consequences

20 Risk Graph III Page 20 of 57 Large amount of boiling water, no step stool, child strapped in a high chair Very High Likelihood Low Moderate High Very Low Consequences

21 Risk Graph IV Page 21 of 57 Small amount of cold water in the pan over a hot stove, step stool next to stove, child not restrained Very High Likelihood Low Moderate High Very Low Consequences

22 Risk Graph V Page 22 of 57 Small amount of cold water over a hot stove, no step stool, child strapped in a high chair Very High Likelihood Low Moderate High Very Low Consequences

23 Individual reflection Page 23 of 57 How do you assess risk in your own labs? Write down your own answers, and then share with others at your table If you wish, share with the class

24 Group Exercise 2, Step 1 Page 24 of 57 Consider the first biological scenario (HIV): Take 15 min to: Identify the risks in this scenario Report out to the class

25 Page 25 of 57 What aspect of biorisk did you focus on?

26 Group Exercise 2, Step 2 Page 26 of 57 Return to the the HIV scenario: In 5 min: Choose one risk to assess Define the hazard and/or threat Can you evaluate the risk of this scenario? If so, what is it (low/moderate/high)? Capture answers on a flip chart, and report to the class

27 Group Exercise 2, Step 3 Page 27 of 57 Using the HIV scenario: Take 20 min to answer the following questions: What different type of information do you need to do a risk assessment? List all questions that you think need to be asked. Use small post-it notes, one per question, and place your post-it notes on a flip chart.

28 Group Exercise 2, Step 4 Page 28 of 57 Categorize the criteria: Take 15 min to: Put the questions, or criteria, into four or five general categories. Place the small post-it notes on top of larger post-it notes that represent the four or five general categories.

29 Risk Assessment Categories of information needed Page 29 of 57 Agent properties (Morbidity, mortality, treatment and prevention, routes of transmission, communicability, agent stability) Laboratory itself (infrastructure, such as floors, walls, cabinets, benches, and other existing elements that contribute to risk, such as animals) People Mitigation measures (four categories) Environment (including the community) Financial aspects

30 Group Exercise 2, Step 5 Page 30 of 57 Using the HIV scenario: Categorize the questions, or criteria, according to Likelihood Consequences Which of these criteria are relatively more important than the others? Capture the results on a flip chart

31 Debrief Page 31 of 57 How might the result of your risk assessment change using this process (compared to your earlier method)? How has your risk assessment improved? Think about how you assessed the risk of the two-year-old in the kitchen and how you assessed the HIV scenario the first time.

32 Page 32 of 57 What are the benefits of a robust risk assessment?

33 Benefits of a Robust Risk Assessment Page 33 of 57 Facilitates a risk assessment process; repeatable/reproducible Facilitates risk mitigation decisions Provides quality control documentation

34 Page 34 of 57 What might be missing from this technical risk assessment?

35 Page 35 of 57 What is 'acceptable risk'?

36 Risk Appreciation Page 36 of 57

37 Risk Appreciation Page 37 of 57

38 Risk Appreciation Page 38 of 57

39 Risk Appreciation Page 39 of 57

40 Individual reflection Page 40 of 57 What was new today? What insights have you had? What implications are there for you? What will you change when you return to your home institute? If you wish, share your thoughts with the class

41 Summary I Page 41 of 57 Hazard (threat) is a source or object that can cause harm Risk is the likelihood of an event with a hazard (or a hazard and threat) that has consequences R = f (L, C) Likelihood is the probability of an event occurring Consequences is the severity of an event

42 Summary II Page 42 of 57 Benefits of a robust risk assessment Facilitates risk assessment process; repeatable/reproducible Facilitates risk mitigation decisions Provides quality control documentation

43 Summary III Page 43 of 57 Technical risk assessments generally do not include perceived social, cultural, political and ethical concerns Risk acceptance will depend on the owner of the risk: risk averse or risk tolerant

44 Day Two Page 44 of 57 Review Exercise 30 min

45 BioRAM Page 45 of 57 Biosafety risk assessment model Biosecurity risk assessment model Both have relied extensively on external experts from the international community BioRAM Lite is the version that was created for this WHO training course The BioRAM models are available through the following website:

46 BioRAM Lite Page 46 of 57 BioRAM Lite is the version that was created for this WHO training course Very simplified; many critical questions and details have been omitted It has limitations, and should not be used to make actual lab safety/security decisions BioRAM Lite asks a series of questions If the question contributes to risk, the score is 0-4 If the question mitigates risk, the score is 4-0 BioRAM Lite has embedded weights for the questions, and the categories of the questions

47 Risk Visualization Page 47 of 57 BioSafety Risk to Lab Worker Inhalation Percutaneous Likelihood 2.00 Contact Ingestion Consequences

48 Group Exercise Page 48 of 57 Divide into groups Refer to your group s scenario Conduct a risk assessment using the BioRAM Lite model

49 Group Exercise 3, Step 1 Page 49 of 57 For each scenario Conduct a safety risk assessment If there is not adequate information to answer the question, assume the risk mitigation is NOT in place Determine risk; plot those risks on the graphs Identify four (~one/page) key risk drivers Take 60 min and be ready to present and explain your risk assessment results to the class

50 Group Exercise 3, Step 2 Page 50 of 57 For each scenario Conduct a security risk assessment If there is not adequate information to answer the question, assume the risk mitigation is NOT in place Determine risk; plot those risks on the graphs Identify four (~one/page) key risk drivers Take 60 min and be ready to present and explain your risk assessment results to the class

51 Scenario A Page 51 of 57 A basic research project uses wild type pablo virus for immune response studies using an animal model. Less than 1 liter volume of material is handled at any time. Researchers conduct necropsies on mice post euthanasia. Personnel wear lab coats over their own clothes. Gloves are worn sporadically. No face shields are in use. The laboratory has a sink, which is used for hand washing, and the washing of glassware. Isolates are kept in a freezer in the hallway next to the laboratory. Laboratory notebooks maintain a log of isolates, and are kept on top of the freezer.

52 Scenario B Page 52 of 57 A laboratory is culturing MDR-Titan Blue for drug susceptibility testing. MDR-TB isolates are grown and exposed to a variety of drugs to determine susceptibility. Open window ventilation, humid environment. Lab coats, surgical masks, gloves worn occasionally. No vaccination available. Lab waste is hauled away for offsite treatment. Open campus with no locks on doors. Cultures not secured or inventoried. No personnel reliability program.

53 Scenario C Page 53 of 57 Researchers are conducting Funny Mutton Disease vaccine challenge studies. Bovines are used for this vaccine challenge. Animals are exposed to FMD via intranasal exposure. Both control and challenge animals are housed in sealed environments, which are isolated from each other, with directional and HEPA filtered exhaust air. Liquid waste is routed through open pipes. Solid waste is sent to public trash disposal. Persons are required to don coveralls and rubber boots prior to entering animal pens; upon leaving animal pens, the coveralls and rubber boots are rinsed with a decontamination solution for reuse. Vaccines being tested have been imported from another country. Lyophilized FMD isolates are stored in a lock box located in the common area of the animal warehouse. Periodically, FMD isolates are grown and lyophilized; this work is done in a laboratory area located at another building.

54 Plenary Discussion Page 54 of 57 What are critical pieces of information you need to conduct a risk assessment? Who should be responsible for conducting this type of risk assessment, and why?

55 Biorisk Management Page 55 of 57 Biorisk Management = Assessment, Mitigation, Performance Risk identification Hazard/threat identification Likelihood evaluation Consequences evaluation

56 Identification of Biorisks Page 56 of 57 Identification of Biorisks Biosafety Risk Assessment Biosecurity Risk Assessment

57 Individual Reflection Page 57 of 57 Imagine you are going back to your labs and have to brief your colleagues about this workshop What are the 10 key messages you would share with them about risk assessment? Be prepared to share your answers with the class

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