Forward Looking Statements
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1 Antiviral Therapies
2 Forward Looking Statements This presentation contains forward-looking statements, including the timing of our drug development programs. Risks include delays in manufacturing created by third parties and the ability of clinical research organizations to recruit patients. Forwardlooking statements also are prefaced by words such as "expect," "plan," "intend," "anticipate," and similar words. Forward-looking statements are based on our current expectations and assumptions regarding our business, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict. Our actual results may differ materially from those contemplated by the forward-looking statements for a variety of reasons, including those contained in our Form 10-K, as amended, for the year ended December 31, We caution you, therefore, against relying on any of these forward-looking statements. They are neither statements of historical fact nor guarantees or assurances of future performance. We do not undertake any duty to update these forward-looking statements. 2
3 Company Highlights Leading antiviral company with several compounds entering the clinic within 2 years 3 Proprietary Technologies Modeling and crystallography Small molecule like antiviral nucleosides CRISPR/Cas9 Multiple Opportunities in Different Viral Diseases Influenza (PB-2 inhibitors, PB-1 Inhibitors, PA Inhibitors) Hepatitis C (nucleoside inhibitors, helicase inhibitors, NS5A inhibitors, non-nucleoside inhibitors) Hepatitis B Norovirus (nucleoside inhibitors, non-nucleoside inhibitors) Human Papilloma Virus Company Board and Leadership Have Proven Track Record Dr. Roger Kornberg and Dr. Raymond Schinazi lead R&D team 3
4 Cocrystal Drug Discovery Process X-ray quality crystal production Drug pocket selection Hit-to-lead process Lead optimization Proprietary ARTIST fragment libraries 4-8 fragments/cocktail Soaked with protein crystals Drug candidates Cocrystals (protein crystals complexed with fragments) 4
5 Crystallography Technology Platform Fragment E Fragment hits Fragment D Fragment A Fragment B Fragment C Photo highlights fragments binding to novel binding sites Identifies novel binding sites unique targets previously undetected by Big Pharma with high-throughput screening Provides 3D structure of inhibitor complexes at near-atomic resolution provides immediate insight to guide structure-activity relationships (SAR) Only company with drug resistant crystals Rapid turnaround of structural information through highly automated X-ray data processing and refinement Ability to quickly grow ultra-high resolution crystals 5
6 Technology Platform Focuses on Viral Replication Drug Targets Through Cocrystalization Building a foundation with high resolution X-ray data (<2Å) >800 cocrystal structures Avg resolution <2Å Photographs of crystals 6
7 Opportunities There exists significant market opportunity across a large variety of viral infections including Influenza A & B Seasonal and pandemic 3-5 million chronic infections/year Estimated economic impact of seasonal flu in US: $50 to $150B Hepatitis B & C Leading cause of liver failure and liver cancer Chronic infections >100 million HCV >400 million HBV Opportunity for shorter duration in HCV and a cure in HBV Norovirus Chronic (potentially orphan indications) as well as Acute gastroenteritis >250 million acute cases/year Economic cost in the US alone is >$5 Billion NO MARKETED DRUG 7
8 Company Pipeline Viral Disease Influenza Lead Discovery Lead Optimization Preclinical IND Phase I/II Lead selection 2016 Hepatitis C (pan-genotypic) CC (NS5B-NNI) CC-1845 (NS5B-Nuc) CC-2069 (NS5A) Helicase Program IND Filing 1H 2016 Lead selection 2016 IND enabling studies Lead selection 2016 Norovirus Hepatitis B 8
9 Influenza Program Influenza leads: PB2, PB1 and PA Inhibitors Focus on three different classes of influenza polymerase inhibitors: PB2 (cap-binding), PB1 (polymerase), and PA (endonuclease) Novel, potent structure-based PB2 inhibitor developed (expect to complete PB2 lead selection in 1H 2016) IND-enabling study of PB2 inhibitor scheduled for 2017 Influenza polymerase complex 9
10 Influenza Program Leads bind to highly conserved binding pocket Selected influenza A PB2 crystals Influenza PB2 inhibitor H1N Virginia H1N Spanish H7N Zhejiang H5N Guangdong H1N H5N H7N H1N
11 HCV Program Highlights IND expected in 1H 2016 for highly potent, pan-genotypic NNI Initiating IND-enabling studies for potential best-in-class NS5A Potential novel first-ever helicase inhibitor Potent series of nucleoside inhibitors in development Several value-inflection opportunities 11
12 HCV Program Combinations Multiple opportunities in developing combination ultra-short, all oral pan-genotypic cure. Multiple possibilities for De-risked near-term approach creating multiple Shots on Goal Pan-genotypic NS5B NNI Pan-genotypic NS5A Inhibitor Pan-genotypic NS5B Nuc Pan-genotypic Helicase Inhibitor combination drugs 12
13 CC-31244: Pan-genotypic NNI Highly potent NS5B polymerase inhibitor (EC 50 = 7 nm) Pan-genotypic activity against all genotypes (1-6) No off-target activities and favorable in vitro ADMET properties No cytotoxicity Excellent activity against common drug resistant variants (IC 50 fold change < 5-fold) Favorable PK properties Liver targeting IND-enabling studies completed 13
14 CC-31244: Pan-genotypic NNI Binding to a highly-conserved drug binding site (NNI-4) (A) HCV NS5B polymerase (B) Highly conserved NNI-4 site among HCV genotypes NNI-4 Ser365 GDD Motif Asn/Cys 316 CC GT-1a GT-1b GT-2a GT-4a GT-6a 14
15 CC-1845: HCV Nuc Chain Terminator CC-1845 terminates HCV RNA replication: X-ray data confirms highly efficient mechanism of action MP-1 NTP-3 NTP-2 NTP-1 HCV RNA Cocrystal s high resolution X-ray structure 15
16 CC-1845: Nucleoside Polymerase Inhibitor Search for next generation backbone for combination therapy To speed-up process, scalable chemistry for CC-1845 (HCV Nucleoside Polymerase Inhibitor) diastereomer separation and additional nucleoside analogs are also being developed towards an IND to select best candidate in Characterization of both diastereomers of CC-1845 will be compared to other drug candidates simultaneously for selection of best, next generation nucleotide prodrug 16
17 CC-2069: Pan-genotypic NS5A Novel, highly potent, pan-genotypic, NS5A inhibitor (GT1b EC 50 < 10 pm) CC-2069 produces a second active metabolite (also a pm HCV inhibitor) No cytotoxicity observed Favorable PK properties Favorable in vitro ADMET properties Potentially an excellent combination drug candidate with Nuc and/or NNI IND-enabling studies in progress 17
18 HCV Helicase Program Provides unique opportunities for drug combinations, especially for salvage therapy Creates a new option for HCV combination therapy First-in-class pan-genotypic inhibitors (new mechanism of action) Highly conserved drug binding mode demonstrated in all genotype crystals developed (1-6) Potentially an ideal combination candidate with HCV NS5B Nuc, NNI, NS5A, and/or protease inhibitors Inhibits essential viral RNA unwinding process 18
19 HCV Pan-genotypic NS3 Helicase Inhibitors HCV genotype crystals (1-6) developed GT1b GT1a GT1b FL GT2a GT3a GT4a GT5a GT6a Pan-genotypic binding mode of HCV helicase inhibitor Genotype 1-6 overlay cocrystal structures 19
20 Norovirus Program Unmet & underappreciated medical need Acute (foodborne) Chronic (Immunocompromised) Chronic (transplant patients) million illness each year (1 in 14 Americans become ill each year) 20
21 Norovirus Program Broad spectrum Noro Polymerase Inhibitors Noro polymerase Highly conserved NNI site NNI Human Noro Human Norwalk Murine Noro Human Norwalk Human Noro Murine Noro GDD Motif 21
22 CRISPR/Cas9 Technologies In-licensed from Duke University and Emory University for Hepatitis B and Human Papilloma Virus Technology allows for editing of viral DNA Potential cure for chronic HBV Next steps: optimization of small Type II Cas9 proteins to continue this work in a humanized mouse model using AAV-mediated transduction of Cas9 and two sgrnas. 22
23 Hepatitis B market There is no approved cure at this time HBV is estimated to have 400M chronically infected globally. The prevalence is still significant with as many as 2M infected with chronic HBV in US alone. Overall prevalence is increased due to immigration from countries where HBV is endemic. Current therapies for HBV are limited and in the majority of cases not finite. There is a significant unmet need to offer a therapy that can eliminate HBV in infected people. 23
24 Transformational Year: 2016 Influenza Select lead PB-2 inhibitor compound Initiate IND-enabling studies of lead PB-2 inhibitor HCV File IND for CC (NS5B-NNI) Complete Phase 1/POC for CC IND-enabling studies of CC-2069 (NS5A) Select lead nucleoside inhibitor for IND-enabling studies Select lead helicase inhibitor for IND-enabling studies 24
25 Financials 4th Quarter 2015 (in millions) R&D Cash Expense $2.7 SG&A Cash Expense $2.0 Cash Balance (12/31/15) $9.3 25
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