YOU NEED CHOICES. Elanco now brings you a comprehensive line of cattle vaccine health management solutions for your operation.

Transcription

1 YOU NEED CHOICES. Elanco now brings you a comprehensive line of cattle vaccine health management solutions for your operation. Single-vaccine solution protects against BRD-causing viruses & bacteria at every stage of production* *Approved for cattle 6 days of age or older

2 Proven and trusted The portfolio of nine Titanium MLV vaccines provides proven protection against respiratory and reproductive viruses. Several combinations are now approved for use in pregnant cows and nursing calves (see product names below). The first BVD type 2 MLV vaccine, Titanium has become well-known for helping protect stocker and feeder cattle against respiratory disease. Research cited below shows Titanium brand vaccines: Did not affect feed intake 2 Did not cause post-vaccinal stress as measured by body temperature, feed intake, injection-site reaction and white blood cell counts 2,3,4,6 Are safe to use in nursing calves and during pregnancy 7 * Did not affect milk production 1 In fact, studies document that the portfolio of Titanium vaccines protects against BVD, types 1a and 2 (Figure 1), IBR, PI 3, BRSV and five strains of Leptospira, including L. hardjo-bovis common pathogens that cause costly respiratory and reproductive disease. 3,,8,9, * Clinical signs* mean score Figure 1. BVD type II challenge study clinical signs 8 Titanium L (intramuscular) Titanium L (subcutaneous) Unvaccinated controls Days post-challenge *Clinical signs monitored included depression, respiratory distress, nasal discharge, diarrhea, oral lesions, ocular discharge, appetite and coughing. Titanium s MLV combination vaccines provide this protection quickly by stimulating cell-mediated immunity (Figure 2). Now, the convenience of whole-herd protection With USDA s approval of four combination vaccines for nursing calves and pregnant cows, Titanium brand vaccines now can protect your whole herd against costly disease pathogens. Be sure to follow label and use directions. T-helper lymphocyte interleukin-2 receptor-level expression index (EI) 2 1 Figure 2. IBR study post-vaccinal cell-mediated immunity 9 Titanium L Unvaccinated controls Days post-vaccination *See reference guide on back cover Four Titanium combinations are now USDA-approved for use in pregnant cows and nursing calves: Titanium + PH-M Titanium L HB Titanium Titanium 4 L

3 Single vaccine with virus and bacteria protection Titanium + PH-M delivers a broad immune response against the bacteria and viruses most associated with bovine respiratory disease (BRD) in a single vaccine for cattle as young as 2 months of age. 11,12,13,14 Protects against the two bacteria most associated with BRD: 11,1 Mannheimia haemolytica the bacterium most frequently isolated from lungs of cattle with BRD Pasteurella multocida an important cause of bacterial pneumonia And five economically important virus strains: 12,13 BVD, types 1 and 2 PI 3 IBR BRSV Contains a research-proven M. haemolytica leukotoxoid and other antigens to stimulate an immune response to BRDcausing viruses and bacteria. Includes a low-reactive 14, water-soluble adjuvant, and is proven safe for cattle as young as 2 months of age. Survival Rate Figure 3. M. Haemolytica challenge study survival rate 11 % 8% Group 1: PH-M Group 2: Titanium + PH-M 6% Control 4% 2% % Day 1 Day 2 Day 3 Day 4 Proven effective and safe at every stage of production* Evaluated under USDA requirements, Titanium + PH-M was proven safe and effective for cattle at all stages of production, with no interference between the viral and bacterial components of the vaccine. Research comparing vaccinated calves to controls after infection with M. haemolytica showed Titanium + PH-M: 11 Reduced lung lesions by 82% (P <.1) Reduced clinical signs of infection significantly (P <.1) Studies also showed Titanium + PH-M: Provided the same viral protection (BVD, types 1 and 2, IBR, PI 3, BRSV) as Titanium 12,13 Protected against severe clinical signs of BRD 11,12,13 Resulted in no adverse events beyond minimal injection-site swelling 14 *Approved for cattle 6 days of age or older Mitigated fraction: the effect of a vaccine in reducing severity of disease Percent of animals Figure 4. Titanium + PH-M safety study injection-site evaluation 14 % 8% 6% 4% 2% % Injection-site swelling measurements <1. cm 1. - cm > cm Day 4-6 Day 21 Day 2-27 Day 42 Calves vaccinated on Day 1 and revaccinated on Day 21. Helping your cattle overcome the one-two punch of viruses and bacteria requires a vaccine solution that provides a broad immune response against the bacteria and viruses most associated with BRD.

4 Two combinations effective -way or -way plus Lepto protection Master Guard vaccines contain a unique combination of killed and MLV components to provide disease protection that s proven safe and effective in cattle including pregnant cows and nursing calves. Cow-calf and dairy producers alike depend on Master Guard brand vaccines to protect against common reproductive and respiratory pathogens in pregnant and open cattle.* To deliver effectiveness and reproductive safety, Master Guard features killed antigens for BVD, types 1a and 2, and IBR (see Figure for duration-of-immunity research). The two MLV components the same as found in Titanium enhance cattle s cell-mediated immune response for BRSV (Figure 6) and PI 3. Lepto antigens add even more reproductive protection Master Guard HB also provides protection against five species of Leptospira spirochetes, including L. hardjo-bovis, the most common species of Leptospira found in the United States. Master Guard vaccines:* Do not affect milk production 16 Can be given to cows and heifers at any stage of gestation Allow the convenience of whole-herd vaccination in cattle months of age and older Clinical signs mean score 2 1 Figure. IBR challenge study clinical signs Days post-vaccination IBR/BVD components in Master Guard Unvaccinated controls Day of IBR challenge. Clinical signs monitored included respiratory distress and rectal temperatures. Trust Master Guard brand vaccines to provide the reproductive safety you want, and the protection you need against key reproductive and respiratory pathogens.* No statistical difference during nine-day duration of study *See reference guide on back cover Gamma delta T-lymphocyte interleukin-2 receptor-level (EI) 2 1 Figure 6. BRSV study post-vaccinal cell-mediated immunity BRSV component in Master Guard & Titanium Unvaccinated controls Days post-vaccination Master Guard offers the safety of a killed vaccine (BVD types 1 and 2, IBR) with the performance of a modified-live vaccine (PI 3, BRSV).

5 General use guidelines When to use vaccines from Elanco are designed to offer the protection you need, when and where you need it. While following label directions, work with your veterinarian to determine the best way to incorporate these trusted vaccines into your herd-health protocols. Titanium + PH-M STOCKER Titanium Master Guard * Arrival Previously vaccinated Revaccinate (two to four weeks) Unknown history FEEDYARD Titanium + PH-M Titanium Titanium 4 L Titanium 3 LP Titanium 3 Titanium IBR Arrival Lightweight, high-risk cattle Revaccinate in two to four weeks Heavyweight, low-risk cattle Reimplanting COW-CALF Calves Heifers and cows Birth Branding/ Preweaning Weaning/ Preconditioning Prebreeding (3 to 6 days before) Breeding Pregnancy Calving Titanium + PH-M Titanium L HB Titanium Master Guard HB* Master Guard * Annual revaccination of cows is recommended When bringing cows and replacement heifers with an unknown health history into your herd: 1. Vaccinate upon arrival 2. Revaccinate in two to four weeks *May be used in calves at least months of age The full value of a true partnership Equipped with a full line of disease treatment, prevention and control solutions, you can count on your Full Value Beef experts at Elanco to help you make informed health management decisions. By establishing a strong foundation in data analytics and helping you identify the economic factors that have the biggest impact on your bottom line, you and your Elanco representative can work together to discover meaningful profit opportunities.

6 YOU NEED CHOICES ELANCO VACCINE REFERENCE GUIDE Titanium + PH-M dose / dose * Titanium L HB dose / dose / dose Titanium dose / dose Titanium 4 L dose Titanium BRSV 3 dose Titanium 3 LP dose Titanium 3 dose / dose Titanium IBR LP dose 3 3 Titanium IBR dose / dose 3 BVD subtype 1a BVD type 2 IBR PI 3 BRSV BVD subtype 1a BVD type 2 IBR Mannheimia haemolytica Pasteurella multocida Leptospira canicola L. grippotyphosa L. hardjo Master Guard 2 dose ** Master Guard HB dose / 2 dose ** * Approved for cattle 6 days of age or older **May be used in calves at least months of age MLV Killed L. hardjo-bovis L. icterohaemorrhagiae L. pomona Approved for pregnant cows, nursing calves For all products: The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions. Do not vaccinate within 21 days of slaughter. Precautions: Do not use Titanium BRSV 3, Titanium 3 LP, Titanium 3, Titanium IBR LP and Titanium IBR in pregnant cows or in calves nursing pregnant cows. Abortions may result. 1 Terhaar, B. 2. Effect of vaccination with Titanium on milk production in dairy cattle. Study No. TR-9. Published by Agri Laboratories Ltd. 2 Terhaar, B. 21. Evaluating the effects of vaccine-induced stress on productivity. Study No. TR-13. Published by Agri Laboratories Ltd. 3 Terhaar, B A comparison of Titanium L and Bovishield 4 L following virulent infectious bovine rhinotracheitis virus challenge. Study No. TR-4. Published by Agri Laboratories Ltd. 4 Terhaar, B Final report on field safety evaluation of Titanium L. Study No. TR-3. Published by Agri Laboratories Ltd. Data available upon request. 6 Terhaar, B. Effect of vaccination with Titanium. Study No. TR-11. Published by Agri Laboratories Ltd. 7 Field safety evaluation in pregnant cows. Study No Rev. No. 1. Published by Agri Laboratories Ltd. 8 Ohnesorge, W. C Immunogenicity of a modified live bovine viral diarrhea virus, type 1 and type 2, vaccine following BVDV 89 (type 2) challenge. Study No Endsley, J. J., M. J. Quade, B. Terhaar, and J. A. Roth. 22. Bovine viral diarrhea virus type 1- and type 2-specific bovine T lymphocyte-subset responses following modified-live virus vaccination. Vet. Ther. 3(4): Immune response of calves to MLV and killed vaccines at branding and weaning -- in the face of maternal antibodies. Study No. TR-2. Published by Agri Laboratories Ltd. 11 Milliken, G. A Mannheimia haemolytica efficacy studies demonstrating the absence of excessive interference of Titanium products with the Mannheimia haemolytica-pasteurella multocida bacterin-toxoid. 12 Demonstration of the compatibility of components between APHIS product codes (Establishment 213) and G93.4 (Establishment 31) APHIS product code 4B9.2. Study No. 2-1 Rev Efficacy study for BRSV fraction to demonstrate compatibility of the BRSV component in APHIS product code: 4B9.2 (unlicensed). Study No Rev Porter, M Field safety evaluation of bovine rhinotracheitis-virus diarrhea-parainfluenza3-respiratory syncytial virus vaccine, modified live virus, APHIS product code (establishment 213) in combination with Mannheimia haemolytica-pasteurella multocida bacterin-toxoid, APHIS product code: G93.4 (establishment 31). Protocol No , Rev The Merck Veterinary Manual. th ed. Respiratory diseases of cattle. p C. Kahn, ed. Merck & Co. Inc., Whitehouse Station, NJ. 16 Terhaar, B. 2. Master Guard Preg : Effect of vaccination on milk production in dairy cattle. Study No. TR-. Published by Agri Laboratories Ltd. 17 Sibbel, R. L., E. P. Bass, and P. C. Thomas How long will a killed IBR vaccine protect against challenge? Vet Medicine Elanco, Full Value Beef, Master Guard, Titanium and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates. 214 Elanco Animal Health. VAC USBBUMUL892