The Fiji Pneumococcal Project. Kim Mulholland,, Fiona Russell
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1 The Fiji Pneumococcal Project Kim Mulholland,, Fiona Russell
2 Overall objectives To provide the Government of Fiji with all the information needed to make an informed decision about the inclusion of pneumococcal conjugate vaccine in their national schedule To define a regimen, or regimens, using both conjugate and polysaccharide vaccines, for effective pneumococcal immunization of young children in remote areas of developing countries
3 Ethical Oversight Fiji National Research Ethics Committee University of Melbourne Ethical Committee
4 Epidemiological component (part funded by NIAID) Burden of ear disease in young children Burden of Hospitalized pneumonia in adults and children national study Burden of radiological pneumonia in children in the area served by the main hospital in Suva, Fiji Burden of meningitis retrospective study prospective study outcome of meningitis, including neurological and quality of life assessments Studies of nasopharyngeal carriage serotypes and resistance Cost effectiveness study
5 Epidemiology - highlights Incidence of invasive pneumococcal disease (IPD) /10 5 children under 5/year Pneumococcal meningitis Incidence in Melanesian Fijians > Indo-Fijians (RR 22) Case fatality rate: 20% for IPD, 26.9% for meningitis Quality of life was reduced in survivors Currently assessing disability rate Serotype 1 commonest IPD isolate (23%) The 7vPCV covers ~50% of IPD isolates in U5s Incidence of CXR-confirmed pneumonia is 428 cases per U5s Melanesian Fijian > Indo-Fijian children CFR 6.8%
6 Other research activities by the same group Group A Streptococcal disease burden study (including skin disease, glomerulonephritis, acute rheumatic fever, rheumatic heart disease) Rotavirus disease burden
7 Pnc isolates from carriage studies
8 Summary of carriage study 31% of isolates covered by the 7-valent conjugate vaccine 46% of isolates covered by the 23-valent polysaccharide vaccine 68% of isolates covered by the 23-V PS vaccine + 7-V conj. vaccine + related, cross reactive serotypes
9 Immunogenicity following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine and booster response of the 23- valent pneumococcal polysaccharide vaccine at 12 months of age Russell FM, Carapetis JR, Tang M, Balloch A, Colquhoun S, Nelson J, Pryor J, Tikoduadua L, Waqatakirewa L, Byrnes G, Mulholland EK
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12 Vaccine trial Original plan: 0,1,2 or 3 doses of conjugate followed by polysaccharide (PS) vaccine at 6 or 9 months All children to get a micro-dose of PS at 15 months Endpoints: Immune responses to conjugate series Immune responses to polysaccharide Immune responses to micro-dose PS Impact of different regimens on carriage
13 Safety concerns raised after 230 infants enrolled: Concerns raised about the safety of PS vaccine in infants under 12 months There were a number of publications of use of PS as young as 3 months, but these were old The theoretical risk of hyporesponsiveness was raised Based mainly on the finding that meningococcal C PS vaccine leads to later hyporesponsiveness to subsequent doses
14 Revised study design Conjugate vaccine 0,1,2 or 3 doses as before: 14 weeks 6 and 14 weeks 6, 10 and 14 weeks PS vaccine or nothing at 12 months Micro-dose PS vaccine at 18 months Antibody assays to all 23 serotypes in the 23V PS vaccine, + functional OP assays to 8 serotypes
15 Geometric mean antibody concentrations 4 weeks after the primary series of 7V conjugate vaccine (µg/ml) serotype 3 doses (n=59) 2 doses (n=44) 1 dose (n=43) 0 doses (n=34) B V C F F
16 Proportion of infants with IgG specific antibody titers >0.35μg/ml following 0, 1, 2 or 3 doses of conjugate vaccine % PCV 2 PCV 1 PCV 0 PCV B 9V 14 18C 19F 23F Serotypes
17 Did those children who had received prior conjugate vaccine have more severe reactions to the polysaccharide vaccine? 0 PCV (n=31) 1 PCV (n=23) 2 PCV (n=18) 3 PCV (n=21) Severe AEs Tenderness Erythema Induration Fever
18 Responses to 12 mths PS vaccine GMT (µg/ml) - Serotype weeks 12 mths 13 mths PCV 1 PCV 2 PCV 3 PCV
19 Serotype 6B weeks 12 mths 13 mths PCV 1 PCV 2 PCV 3 PCV
20 Serotype 9V weeks 12 mths 13 mths PCV 1 PCV 2 PCV 3 PCV
21 Serotype weeks 12 mths 13 mths PCV 1 PCV 2 PCV 3 PCV
22 Serotype 18C weeks 12 mths 13 mths PCV 1 PCV 2 PCV 3 PCV
23 Serotype 19F weeks 12 mths 13 mths PCV 1 PCV 2 PCV 3 PCV
24 Serotype 23F weeks 12 mths 13 mths PCV 1 PCV 2 PCV 3 PCV
25 Other serotypes included in PS GMT µg/ml vaccine mths 13 mths F 8 9N 10A 11A 12F 15B 17F 19A 20 22F 33F
26 Serotype 9N mths 13 mths PCV 1 PCV 2 PCV 3 PCV
27 Serotype 19A mths 13 mths PCV 1 PCV 2 PCV 3 PCV
28 Serotype 19A PCV 1 PCV 2 PCV 3 PCV 12 mths 13 mths
29 Analyses to come Full data set for above analyses Responses to micro-ps dose at 18 mths Avidity assays for all groups Functional assays to 8 serotypes Impact on carriage of VT and non-vt pneumococci in various groups
30 Preliminary conclusions Based on ELISA assays 3 doses of Pnc conjugate are not superior to 2 doses Pnc polysaccharide vaccine given at 12 months is safe and immunogenic Combination of polysaccharide with conjugate vaccine will cover 68% of isolates in Fiji
31 Future of pneumococcal vaccination in Fiji Applied to PneumoADIP for early introduction effectiveness study Options to Government of Fiji: 2 nd phase of vaccine studies to address earlier PS vaccine and alternative PCV formulation Early introduction of Prevenar/PS based on FiPP results
32 Acknowledgements Funding agencies DMID/NIAID, NHMRC (Australia) FiPP Project Sam Colquhoun, Adam Jenney, Viema Kunabuli, Jane Nelson, Fiona Russell (PI), Anna Seduadua Fiji School of Medicine Jan Pryor, Lisi Tikoduadua, Sharon Biribo Fiji Ministry of Health Lepani Waqatakirewa University of Melbourne Amy Auge, Graham Byrnes, Jonathan Carapetis, Katherine Gilbert, Amanda O Brien (Project Manager), Karen Stephenson Murdoch Children s Research Institute Immunology Lab Anne Balloch, Paul Licciardi Mimi Tang, International collaborators Moon Nahm (U Birmingham), Helena Kayhty, Anu Nuurka (KTL Finland),
33 Thanks to the families of Fiji for their enthusiastic support for this project
Polysaccharide and conjugate vaccine responses
Hyporesponsiveness Kim Mulholland Murdoch Childrens Research Institute, Melbourne London School of Hygiene and Tropical Medicine, UK University of Melbourne, Australia Hyporesponsiveness Reduced or absent
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