Clinico-epidemiological profile of malaria: Analysis from a primary health centre in Karnataka, Southern India GJMEDPH 2012; Vol.

Transcription

1 GLOBAL JOURNAL OF MEDICINE AND PUBLIC HEALTH Clinico-epidemiological profile of malaria: Analysis from a primary health centre in Karnataka, Southern India GJMEDPH 2012; Vol. 1 issue 6 Ramachandra Kamath 1, Sneha Gaitonde 2 *, Pooja Tripathi 2, Dhritiman Das 2, Mayuri Banerjee 2, Myna Shetty 2, Sandeep Kumar Nayak 2, Md. Asadullah 2 ABSTRACT Malaria continues to be a major public health problem in India and worldwide. The present study was based on records from a primary health centre in Karnataka. Morbidity patterns and important features of malaria transmission specific to Udupi district were investigated. The incidence of malaria and various morbidity patterns during 2010 and 2011 were compared and analyzed. Factors such as rapid urbanization, increased construction activities and influx of migratory workers were highlighted as the leading causes for the advent of malaria in the area. Recommendations have been provided for implementation in the near future. INRTRODUCTION 1 Head of Department 2 Postgraduate Student Department of Public Health, Manipal University, Manipal , Karnataka, India *Corresponding Author Department of Public Health, Manipal University, Manipal , Karnataka, India sneha.gaitonde@gmail.com Funding none Conflict of Interest none Malaria continues to be a heavy social and health burden in India, with an estimated 1.52 million cases reported in 2009 that accounted for 60% of cases in the SEAR 1. With nearly 95% of its population residing in malaria-endemic areas, India is battling the burden through implementation of the National Vector Borne Disease Control Program (NVBDCP). Through continuous efforts of the NVBDCP, malaria is now on a declining trend but P. falciparum cases are increasin 3. The states severely inflicted include Uttar Pradesh, Bihar, Karnataka, Orissa, Rajasthan, Madhya Pradesh and Pondicherry 2. Karnataka, in particular is witnessing an increasing incidence of malaria cases over the past 5 years due to increase influx of migrant population. Manipal is a small, rapidly urbanizing geographical unit of Udupi District; part of the coastal belt of Karnataka with higher levels of average annual rainfall and humidity. A study done by Kamath et al. (2009) in Udupi comparing the malaria situation between 2008 and 2009 in the district reported a rapidly increasing prevalence of malaria in the district. Another hospital based study done in Manipal indicated high prevalence of P. falciparum and P. vivax among the subjects inflicted with malaria 2. In the present study, we assess the various factors influencing the rise in malaria cases reported in areas under Primary Health Centre - Hiriadka in Udupi District, Karnataka. Our study aims to determine the burden of malaria in the area, assess morbidity patterns as well as identify barriers to access to prevention and treatment. MATERIALS AND METHODS A retrospective record based study was undertaken and case records over a period of 2 years ( ) were reviewed at Primary Health Centre Hiriadka in Udupi district. Udupi District is a coastal district of Karnataka state with an area of 8,441 km2 with 29% covered by forest area and has a population density of people/km 2. The summer season is from March to May followed by rainy season in the months of June to September, with an average annual rainfall of 3,940 mm and relative humidity of 55 60% 5. This study included confirmed cases of malaria reported from 1st January 2010 to 30th September 2010 and 1st January 2011 to 30th September Vol. 1, No

2 All patients were tested positive for malaria parasite via either blood smear test or rapid diagnostic test were included in this study. Patient records were retrieved from Primary Health Centre - Hiriadka. The number of malaria cases reported in Hiriadka, Udupi district during 2010 and 2011 were compared and analyzed using SPSS 16.0 software. RESULTS The following figures display data as reported by PHC - Hiriadka from the months of January September in years 2010 and 2011, respectively. A total of 3614 slides were collected from January September 2010, out of which 136 were positive (22.8% P.f.; 77.2% P.v.). In 2011, a total of 6917 slides were collected, out of which 186 were positive (16.1% P.f.; 83.9% P.v.). Rainfall is one of the most important natural factors that influence the transmission and distribution of malaria4. Positive cases were more frequent in rainy seasons (June-Sept) with a steady increase in the number of cases starting in April. In 2010, the highest number of cases was reported in June (32; 23.5%). In 2011, number of positive cases started increasing in May and the highest number of cases were reported in September (52; 28.0%). Demographic Analysis In both 2010 and 2011, majority of positive cases were male (83.8% and 81.7%, respectively). Majority of positive cases were in the age group of years (40.44% and 36.56%, respectively), followed by years (34.56% and 27.42%, respectively) in both years. Figure 1: Distribution of Malaria Cases According to Place In 2010, out of 136 cases, 110 (80.88%) were reported from construction sites and only 26 (19.12%) cases reported from other sites (Figure 1). In 2011, out of 186 cases, 170 (91.4%) were reported from construction sites and only 16 (8.6%) cases reported from other sites (Figure 1). Please note: Other in Figure 1 refers to any place other than Construction Site. Treatment Analysis In both years, majority of positive cases were P. vivax (76.47% and 84.85%), followed by P. falciparum (20.6% and 14.52%) and mixed (2.94% and 0.54%) types. 2 Vol. 1, No

3 Figure 2: Post-Treatment Result Following radical treatment, majority of cases (90.4% and 54.5%, respectively) tested negative. However in 2011, nearly half (42.5%) of cases were reported absent on the follow-up 6th day, resulting in lack of posttreatment results (Figure 2). 3 Vol. 1, No

4 Figure 3: Incidence of Malaria as reported by Hiriadka PHC from Jan. to Aug (N=124) and 2011 (N=134) Figure 4: Incidence of Malaria as reported by Hiriadka PHC in Aug (N=10) and 2011 (N=35) DISCUSSION From the months of January to August, there was an overall 8.1% increase in reported malaria cases from 2010 to While the number of P. falciparum cases remained constant, a significant 12.5% increase in P. vivax cases were observed (Figure 3). There was a significant increase in the number of malaria cases in the month of August from 2010 to For the month of August alone, there were three fold greater cases in 2011 than the prior year (Figure 4). Malaria continues to be a major public health problem in South India with majority of cases observed during the period of monsoon and the time immediately following the end of monsoon (June to October), when water logging helps mosquito breeding and hence the transmission of the disease. In 2011, majority of cases were reported in September (28%) while in 2010, majority of cases (23.5%) were reported in June. Kamath et al. (2009) found majority of cases in the month of July and August in the same district 6. The peak in September 2011 may be a result of climate change and delayed onset of the monsoon season or the steady increase in urbanization in the area bringing in greater numbers of migratory workers. An overall increase in positive cases was found from 2010 to Demographic Analysis The place-wise distribution of malaria in 2010 and 2011 in the area under PHC Hiriadka, Udupi district reveals that majority of positive cases are reported at construction sites. This may be due to growing urbanization and 4 Vol. 1, No

5 construction activities taking place in the surrounding area. Poor management at construction sites provides ideal breeding conditions (such as stagnant water) for the Anopheles mosquito. Factors such as poor living conditions, overcrowding, high man-tomosquito contact and limited or lack of health seeking behavior contributes to accelerated transmission of the disease. Our results show that the majority of positive cases were male in the age group of years, which is consistent with previous studies.2,3,5 Majority of cases appeared to be young construction workers who also happened to be migrants. Constant travel between high-malaria endemic regions puts migrant workers at increased risk for acquiring the disease. Treatment Analysis The present results are consistent with the incidence pattern as reported by earlier workers in different parts of India 3-5. While the overall incidence of P. falciparum is less in 2011 compared to 2010, P. vivax appears to be on an upward trend. There was a significant difference in the post-treatment results from 2010 to In 2011, nearly half of positive cases were absent for the followup resulting in no data of the post-treatment result. This may be due to an increase in migratory population in the area. These findings highlight the barriers to addressing the malaria situation among migratory populations. From the months of January to August, there was an overall 8.1% increase in reported malaria cases from 2010 to While the number of P. falciparum cases remained constant, a significant 12.5% increase in P. vivax cases was observed. In the month of August alone, a significant increase of more than three-fold malaria cases was observed from 2010 to RECOMMENDATIONS Awareness of malaria and preventive measures in the community (promote use of bed nets, mosquito coils etc.) Effective communication between health care professionals and employers to reach common goals There should be regular monitoring of the collection of water, cement or debris; and stagnant water reserves should be frequently cleared off before the onset of breeding of mosquitoes. Labourers, staying at the site should be provided with hygienic accommodation Labourers should be provided with insecticide impregnated nets in order to repel mosquitoes Pre-placement examination of labourers to screen whether they are carrying the parasite from their native place. CONCLUSION Overall, our findings suggest that rapid urbanization, increase in construction work and the influx of migratory populations are the main causes for the advent of malaria in the area surrounding PHC Hiriadka in Udupi district. The numerous construction sites in the region are providing ideal conditions for mosquito breeding. Migrant laborers mostly from West Bengal, Bihar and neighboring districts reside at these sites, putting them at greatest risk. Our results also show that the increase in migratory populations may be a leading cause for loss to follow-up after treatment. This poses a great challenge for healthcare professionals as well as greater 5 Vol. 1, No

6 concern for reducing the burden of the disease in the community. Though it lies beyond the scope of our study, steps should be taken to ensure effective monitoring and tracking of migratory workers. A step that is crucial to combat this major public health issue. referral centre in South Canara. Journal of Vector Borne Diseases. 2006;43: Kamath R, Pattanshetty S, Durgad K. A study on malaria situation in South India- A retrospective analysis AUTHOR S DISCLAIMER The opinions expressed in this paper are those of the authors and may not reflect the position of their employing organizations. ACKNOWLEDGEMENTS We acknowledge Dr. Leonard Machado for his valuable guidance. We also acknowledge the support of Primary Health Centre Hiriadka, Udupi district. REFERENCES 1. World Malaria Report Available from URL: a_report_2011/en/index.html. Accessed on 01/11/ Gurang B, Bairy I, Jagadishchandra, Manohar C. Evaluation of Falcivax against Quantitative Buffy Coat (QBC) for the Diagnosis of Malaria. International Journal of Collaborative Research on Internal Medicine & Public Health. 2010;2(5): Chowta MN, Chowta KN. Study of Clinical Profile of Malaria at KMC Hospital, Attavar, India. Journal of Clinical and Diagnostic Research. 2007;1(3): Talawar AS, Pujar S. Epidemiological situation of malaria in irrigated areas: A case study of Raichur district, Karnataka. Karnataka Journal of Agricultural Sciences. 2011;24(2): Muddaiah M, Prakash PS. A study of clinical profile of malaria in a tertiary 6 Vol. 1, No