Mecadox. Improves pig performance in a wide range of health and growing conditions. (Carbadox) Talk With a Phibro Expert:

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1 SWINE (Crbdox) Improves pig performnce in wide rnge of helth nd growing conditions

2 The Advntge Over the yers, medicted feed dditive hs proven to be cost-effective mngement tool for improving pig performnce in wide rnge of helth nd mngement situtions. Numerous studies hve documented tht use improves rte nd efficiency of pig growth regrdless of helth sttus, genetic cpcity for len growth, niml density, fcility type or pig mngement prctices. Improve pig performnce, even in limited spce conditions. When niml flow schedules get pressured or during the lst weeks in the nursery, pig spce cn be limited. helps mintin pig performce in these situtions. Effect of in Nursery Pigs Rered in Limited or Adequte Floor Spce, g/ton Dy 0 to 28 Pen spce 0 50 Unit chnge Percentge chnge ADG (lb/dy) Limited % Adequte % F/G rtio Limited % Adequte % ADFI (lb/dy) Limited % effect significnt t P<.05. Adequte % Adpted by B.R. Grmm nd R.D. Nimmo from Yen, J.T. nd W.G. Pond Effect of Dietry Supplementtion with Vitmin C or Crbdox on Wenling Pigs Subjected to Crowding Stress. Journl of Animl Science. 64: After 28 dys, the crowded pigs (llowed only 1.4 sq ft/pig) fed were pproximtely 5.0 lb hevier nd hd 10% better feed conversion thn non-medicted pigs. With pigs llowed mple floor spce (2.7 sq ft/pig), use resulted in similr performnce improvements. The results of this study show tht is vitl to mintining performnce during the lte nursery period when verge dily gin (ADG) is greter nd feeder nd pig spce is limited. This is especilly importnt when you consider tht the ccelerted len growth tht tkes plce in the nursery cnnot be recovered lter in life. 2

3 Extended Feeding of pys. A 42-dy withdrwl llows to be used s growth mngement tool beyond the nursery. Wen-to-finish reserch concludes pigs fed step-down diets, ll the wy to 180 lb*, showed substntil improvement in growth rte nd feed utiliztion versus non-medicted pigs. Benefits in Wen-To-Finish Buildings Dy 0 to 128 Non-Medicted,, Unit chnge 50/25/10 b Unit chnge 50/50/25 b ADG (lb/dy) F/G rtio Dietry level in g/ton b tretment versus non-medicted; differences in ADG nd F/G were sttisticlly significnt (P<.05). * must be withdrwn from rtions 42 dys before slughter Adpted by B.R. Grmm nd R.D. Nimmo from Hoover, T.C Comprison of vs. Tyln in Step-Down Feeding Progrms from Wening to Mrket. Pfizer Animl Helth Technicl Bulletin MX Bottom line, cn help you mrket more pork. Pigs were 7.3 lb hevier on the 50/25/10 progrm nd 10.1 lb hevier on the 50/50/25 progrm. Improve performnce in pigs with high len growth potentil. Most pigs hve high genetic cpcity for len growth. is n effective growth-enhncing gent, which cn help improve the growth of your high len gin pigs. Improved feed efficiency llows pigs to mke more efficient use of some of the most costly components of their diet - mino cid sources like soyben mel nd synthetic lysine nd threonine. Using helps pigs mke better use of nutrients resulting in fster gins nd better feed conversion. 3

4 Reserchers t Iow Stte University found provided significnt improvement (F/G & ADG) in pigs with high genetic cpcity for len issue growth. Growth Response to in Pigs with Genetic Cpcity for Len Tissue Growth Item 13 to 75 lb BW ADG, lb b F/G rtio c 13 to 250 lb BW ADG, lb F/G rtio d Tenth rib, in e (Bckft) Loin eye, in e Muscle, (%) e Ft, (%t) e Genetic Cpcity, g/ton 0 50 Unit chnge fed from 13 to 75 lb. body weight b Genotype x effect, (P<.01) c Genotype x effect, (P <.13) d Genotype x effect t 250 lb significnt (P<.16) e Genotype x effect t 250 lb significnt (P<.09) Adpted by B.R. Grmm nd R.D. Nimmo from Sthly, T.S., N.H. Willims nd S.G. Swenson Growth Response to Crbdox in Pigs with or Genetic Cpcity for Len Tissue Growth. Iow Stte University Swine Reserch Report ASL-R1368. len gin pigs fed to 75 lb reched mrket weight (250 lb) in 7.2 fewer dys, required 33.2 lb less feed nd hd n bsolute improvement in crcss muscle content of 1.8%. The economic implictions re less feed use per pig nd fewer dys to mrket. 4

5 Improve performnce under respirtory disese chllenges. Every swine producer fces respirtory disese chllenges t some point. While does not specificlly tret respirtory disese, reserch conducted by Iow Stte University hs shown tht pigs chllenged by respirtory pthogens (Mycoplsm hyopneumoni, APP nd PRRSV) nd fed demonstrted better feed efficiency nd better ADG thn similrly chllenged, non-medicted pigs. Impct of on Pigs Chllenged With Respirtory Disese 12 to 250 lb BW ADG,lb F/G rtio,,b,c Tenth rib, b Loin Eye,in 2,b,c Muscle (%),,b,c Ft (%),,b Immune System Activtion, g/ton 0 50 Unit chnge effect t 250 lb significnt (P<.05), b effect (P<.05), c IS x effect (P<.15) Adpted by B.R. Grmm nd R.D. Nimmo from Sthly, T.S., N.H. Willims nd D.R. Zimmermn Impct of Crbdox on Rte nd Efficiency of Len Tissue Accretion in Pigs With or Level of Immune System Activtion. Iow Stte University Swine Reserch Report ASL-R1162. In this tril, ws fed from 12 to 75 lb t 0 or 50 g per ton. All pigs were fed the sme non-medicted rtion from 75 to 250 lb bodyweight. At slughter, the pigs possessed positive titers for Actinobcillus pleuropneumonie, Mycoplsm hyopneumoni s well s porcine reproductive nd respirtory syndrome (PRRS). fed to 75 lb bodyweight improved rte, efficiency nd composition of growth (reduced ft % nd incresed muscle %) when mesured t 250 lb bodyweight. 5

6 Effective Enteric Disese Control Enteric diseses pose costly threts to the swine industry through poor growth, deth loss nd mediction expense. in pig diets offers effective control of enteric pthogens including Slmonell choleresius, cuse of slmonellosis, nd Brchyspir hyodysenterie, cuse of swine dysentery. The following studies show how mintins growth in pigs fcing enteric disese chllenges. Enteric Chllenge Study 1, g/ton Dy 0 to Unit chnge ADG (lb/dy) F/G rtio ADFI (lb) effect significnt t (P<.05). 1 Adpted by B.R. Grmm nd R.D. Nimmo from Winkelmn, N.L. nd P.A. Hwkins Evlution of Crbdox nd Neomycin-Oxytetrcycline for Control of Prolifertive Enteropthy (Ileitis) in Swine. IPVS Proceedings. p Slmonell Chllenge Study 2, g/ton Dy 0 to Unit chnge ADG (lb/dy) F/G rtio Adpted by B.R. Grmm nd R.D. Nimmo from Olson, L.D., et l Comprison of Furzolidone nd Crbdox in the Feed for Tretment of Slmonell choleresuis in Swine. Am J Vet Res. Vol. 38, 10: No sttisticl differences reported for the dt presented. While is not lbeled for tretment of ileitis, pigs chllenged with ileitis nd fed rtions including were 9.7 lb hevier nd hd 11% better feed conversion thn non-medicted pigs. This study provides strong support tht improves growth performnce in pigs chllenged with ileitis. In the presence of clinicl slmonellosis, pigs fed diets including verged 7.9 lb more gin on 10.9% less feed per pound of gin throughout the study period. Morbidity nd mortlity rtes cused by bcteril enteritis (Slmonell choleresuis) were lso significntly reduced with use. 6

7 Exmple Progrms for Respirtory nd Enteric Disese Control nd Growth Enhncement Nursery Diets Rtion 1 Rtion 2 1 Rtion 3 Rtion 4 50 g/ton 25 g/ton Terrmycin 10 mg/lb body weight for 7 to 14 dys Grow/Finish Diets 50 g/ton 50 g/ton Rtion 1 1 Rtion 2 1 Rtion 3 Rtion g/ton Terrmycin 10 mg/lb body weight for 7 to 14 dys 25 g/ton Terrmycin 10 mg/lb body weight for 7 to 14 dys 25 or 10 g/ton Cost-effective control of respirtory nd enteric diseses while providing growth enhncement. 1 Additionl 7 to 14-dy pulse dosing of Terrmycin cn be used in herds encountering severe respirtory chllenges nytime to mrket weight. PRRS positive pigs chllenged with secondry respirtory infections should be pulsed 2 to 3 times. 2 Feed up to 180 lb bodyweight (withdrw 42 dys prior to slughter) Animl Drug Dosge Level Indictions (crbdox) g/ton ( %) For incresed rte of weight gin nd improvement of feed efficiency. Swine (crbdox) 50 g/ton (0.0055%) For control of swine dysentery (vibrionic dysentery, bloody scours or hemorrhgic dysentery); control of bcteril swine enteritis (slmonellosis or necrotic enteritis cused by Slmonell choleresuis); for incresed rte of weight gin nd improvement of feed efficiency. FDA Sttus: Feed mill license required if the source of crbdox contins more thn 2.5 g/lb. (0.55%). Regultion WARNING STATEMENT REQUIRED: Do not feed to swine within 42 dys before slughter. CAUTION: Do not use in feeds contining bentonite. Not for use in pregnnt swine or swine intended for breeding purposes Animl Drug Dosge Level Indictions Swine (crbdox) nd Terrmycin (oxytetrcycline) g/ton 10 mg/lb bodyweight For tretment of bcteril enteritis cused by Escherichi coli nd Slmonell choleresuis susceptible to oxytetrcycline. For tretment of bcteril pneumoni cused by Psteurell multocid susceptible to oxytetrcycline. For incresed rte of weight gin nd improved feed efficiency. FDA Sttus: Feed mill license required if the source of crbdox contins more thn 2.5 g/lb. (0.55%). Regultion WARNING STATEMENT REQUIRED: Do not feed to swine within 42 dys before slughter. Not for use in pregnnt swine or swine intended for breeding purposes. LIMITATIONS FOR USE: Feed continuously for 7 to 14 dys. Tlk to your veterinrin or niml helth supplier tody to discover the cost-effective dvntges of dding to your pig diets. 7

8 Discover The Advntge Improved pig performnce in wide rnge of helth nd growing conditions --Presence of enteric disese chllenges ---helth or low-helth sttus --SEW or conventionl nursery mngement --Crowded or dequte floor spce ---len genetic potentil --Wen-to-finish buildings --New or used fcilities Effective control of enteric pthogens Promotes growth while it fights disese Cn be used in nursery, grower nd erly finisher diets Multiple pproved dosges nd combintions MX17006USA1217 Phibro Animl Helth Corportion. Phibro, Phibro logo design, Helthy Animls. Helthy Food. Helthy World. nd re trdemrks owned by or licensed to Phibro Animl Helth Corportion or its ffilites. Terrmycin is registered trdemrk of Pfizer Inc, licensed to Phibro Animl Helth Corportion.

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