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1 % ells with ili (mrke y A-Tu) Reltive Luiferse % ells with ili (mrke y Arl13) % ells with ili DOI: 1.138/n2259 A-Tuulin Hoehst % Cilite Non-ilite -Serum 9% 8% 7% 1 6% % 4% +Serum 1 3% 2% 1% % Serum: - + Dnh2+/+ Dnh2-/- Cilite Non-ilite Cilite Non-ilite Dnh2: +/+ -/- Dnh2: +/+ -/- NCl LiCl A-Tuulin Hoehst 15μm μm Averge ili length NCl LiCl e LiCl: Dnh2+/+ Dnh2-/- Figure S1 Cili quntifition in MEFs.. Stining for ili (etylte tuulin, re, rrow) in serum strve MEFs with repplition of serum. These results re quntifie t the right for t lest 2 ells. P<.5, Chi-squre test. Nulei re lele with Hoehst (lue).. Stining for the primry ilium (etylte tuulin, re, rrow) in Dnh2 MEFs revels loss of ili in Dnh2-/- MEFs. These results re quntifie in the pnel on the right for t lest 2 ells. P<.5, Chi-squre test.. Quntifition of perent ilite Dnh2 mutnt MEFs using n ntioy for n lterntive ili mrker Arl13. P<.5, Chi-squre test.. Stining for ili (etylte tuulin, re, rrows) in MEFs serum strve n trete with NCl or LiCl. Averge ili length ws quntifie from over 3 ells from three regions of the well for eh tretment. e. Luiferse tivity in Dnh2 MEFs with tivtion of the pthwy with lithium (LiCl). P<.5, n=3 inepenent experiments, Stuent s t-test. Error rs represent S.E.M. 1
2 % ells with ili 75 kd Kif3 sirna Kif3A α-tuulin WB A-Tuulin Hoehst Cilite Non-ilite % 9% 8% 7% 6% 1 % 4% 3% 2% Kif3 sirna 1 1% % Kif3 sirna β-tenin A-Tuulin β-t Tu Hoehst Untrete ilite nonilite 5μm 5 Figure S2 Kif3 knokown n quntifition of ilition.. Western lot nlysis of whole ell lystes from 293Ts trnsfete with Kif3A sirna. Alph-tuulin is shown s loing ontrol.. Stining for ili (etylte tuulin, re) in MEFs trnsfete with Kif3 sirna #3. Arrows point to ili in ontrol trnsfete ells. Hoehst (lue) lels nulei. Results re quntifie t the right from t lest 2 ells for eh. P<.5, Chi-squre test.. β-tenin-gfp (green) loliztion in untrete ilite (etylte tuulin, re) n nonilite MEFs. Arrow points to sl oy lolize β-tenin in ilite ell. Hoehst (lue) lels nulei. 2
3 Nuler β-tenin (men grey vlue) β-tenin A-Tuulin Hoehst Merge Cilite Non-ilite Cytosol/memrne Nuleus Dnh2: +/+ -/- -/- +/+ Wnt3: β-tenin Jn m-414 WB Dnh2: +/+ -/- Tuulin Wnt3: Jn Tuulin Figure S3 β-tenin n Jn re sequestere in the presene of ili.. Stining for enogenous β-tenin (green) in ilite (tylte tuulin, re) n nonilite (rrow) IMCDs reveling inrese nuler (Hoehst, lue, outline) loliztion of β-tenin in nonilite ells ompre with ilite neighoring ells.. Quntifition of nuler β-tenin stining in ilite n nonilite IMCDs. Men grey vlues were lulte using ImgeJ softwre (NIH) to rete inry msk from Hoehst stining s nuler ounry for mesurement of β-tenin levels. P<.5, n=2 nonilite n n=48 ilite ells, Stuent s t-test. Error rs represent S.E.M.. Western lot (WB) for β-tenin n Jn from nuler preps of Dnh2+/+ n -/- MEFs trete with Wnt3 onitione mei. The inrese in nuler β-tenin levels in Dnh2-/- ells is more pronoune ompre with +/+ ells. Aitionlly, Jn exhiits inrese nuler levels in Dnh2 -/- ells. M414 is shown s nuler loing ontrol n Alph-tuulin is ytosoli ontrol.. Western lot for Jn from totl ell lystes from Dnh2 mutnt n ontrol MEFs trete with Wnt3 onitione or L ell onitione mei. Alph-tuulin is shown s loing ontrol. 3
4 Reltive Luiferse -tuulin Jn-GFP Merge A-Tuulin Arl13 5 µm 1 µm 1 µm β-ctδn: EV Jn EV Jn Kif3 sirna Wil-type RVxP -Tu Jn-GFP 15 µm 15 µm e 1 kd WBL WCL Sup. Sup. + Txol Pellet Pellet + Txol Jn f Dh2 RNAi: Con sirna 1 sirna 2 sirna 3 DCX 2 Dnh2 α-tuulin terk 2 Dnh1 Figure S4 Loss of ili potentites Jn s role in the Wnt pthwy.. 293T ells stine for ili with ntioy to etylte tuulin (re) isply ler ili with Jn-GFP (green) lolize to the sl oy similr to previously esrie in other ilite ells 2. Hoehst ws use to stin the nuleus (lue).. Cili stining of 293T ells with two inepenent mrkers: etylte tuulin n Arl13. Arl13 revels greter numer of ili (44% of ells) thn etylte tuulin stining (1% of ells).. Luiferse tivity in MEFs trnsfete with Kif3 sirna n overexpresse Jn or EV with tivtion of the pthwy with otrnsfete β-tδn. P<.5, n=3 inepenent experiments, Stuent s t-test. Error rs represent S.E.M.. Loliztion of wil-type n ΔRVxP muttion (GFP tgge onstruts, green) to primry ili (lele y etylte tuulin, re) of MEFs. Hoehst (lue) lels nulei. Arrows point to ili. Arrowhes point to sl oy loliztion of Jn wil-type onstrut. e. Mirotuule ssoition ssy in P5 mouse ereellum lystes followe y western lotting revels enogenous Jn ssoite with repolymerize mirotuules in the Pellet n Pellet + Txol frtions. Blots were proe for Douleortin (DCX) s positive ontrol, n totl ERK s negtive ontrol. α-tuulin is enrihe in pellet frtions. f. Western lot nlysis of whole ell lystes from 3T3s trnsfete with Dnh2 sirna onstruts. Dnh2 levels were speifilly erese in sirna-1 n sirna-2 trnsfete ells without n effet on ynein hevy hin 1 (Dnh1) whih is lso shown s loing ontrol. 4
5 Reltive Luiferse % ells with ili Nonilite MEFs (+ serum) 3 N.S Dnh2 sirna: LCM WCM Low ose High ose A-Tuulin Hoehst 6% % 4% 3% 2% 1% % Low ose High ose % ells with 2 ili Aphiiolin A-Tuulin Merge Aphiiolin: - + Figure S5 Dnh2 sirna n phiiolin tretment effet on ilition.. Luiferse tivity in MEFs without serum strvtion n trnsfete with 5 pmol Dnh2 sirna n trete with WCM or LCM. N.S.=not signifint, n=3 inepenent experiments, Stuent s t-test. Error rs represent S.E.M.. Stining for ili (etylte tuulin, re, rrow) in MEFs trnsfete with low ose n high ose (3-fol higher) Dnh2 sirna. Hoehst (lue) lels nulei. These results re quntifie in the pnel on the right for t lest 2 ells. P<.5, Chi-squre test.. Stining for ili (etylte tuulin, re, rrows) in serum strve MEFs trete with 1 μg/ ml phiiolin (APH) or vehile.. Quntifition of perent of ells with two ili from t lest 2 ells for eh tretment. P<.5, Chisqure test. 5
6 Supplementry Figure 6 Dnh2 mutnt BATgl- Mesnephros BATgl+ E9.5 1 mm 1 mm β-gltosise Hoehst 3 μm 3 μm Lung Dnh2 mutnt Lim u Dnh2 mutnt Dnh2 mutnt Arl13 β-gl Hoehst β-gltosise Arl13 2 μm 2 μm 2 μm 2 μm e β-ctenin Hoehst β-ctenin Arl13 Hoehst Metnephros Dnh2 mutnt 2 μm 2 μm Arl13 Hoehst 2 μm 2 μm 2 μm 2 μm Figure S6 Dnh2 loss les to vrying effets on ili n Wnt signling.. Whole mount imges of X-gl stine E9.5 ontrol n Dnh2 mutnt emryos reveling inrese Wnt tivity in the mi-hinrin region n nsl fols (rrows).. β-gltosise stining (green) of E9.5 BATgl+ n BATgl- ontrol mesonephros (outline). Hoehst (lue) lels nulei.. Wnt reporter stining (β-gltosise, green) in representtive E11.5 lung n lim u of Dnh2 mutnt n ontrol littermte. Arl13 (re) stins ili in these tissues. Cili (rrows) re retine in lung n lim u. Hoehst lels nulei (lue).. High mgnifition imge reveling ili (re, Arl13 stining) in ontrol n Dnh2 mutnt emryos. Hoehst lels nulei (lue). Arrows point to ili, while rrowhe points to pprently ulous ili of Dnh2 mutnt emryo. e. β-tenin stining (re) in E11.5 metnephros (outline) of littermte ontrol n Dnh2 mutnt emryos reveling erese nuler stining (rrows) in mutnts ompre with ontrols. Ajent setions (ottom pnels) were lso stine for ili (Arl13, green). Hoehst stining (lue) lels nulei. 6
7 Figure 5 Jouerin Ki67 α-tuulin Figure S7 Full western lot sns. 7
Cos7 (3TP) (K): TGFβ1(h): (K)
IP#2: IP#1: Totl Lystes luiferse tivity (K): 6-4 - (K): luiferse tivity luiferse tivity (K): 2 1 RL-: - + + + + + Sm4-3F: + - + + + + MYC-Sm3: - - - - + + TβRI-HA(T204D): - - - + - + α-ha Luiferse Ativity
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{ OI: 1.138/n31 Srifie n nlyze APs on week 1 s of iet 1 4 6 High-ft iet BrU High-ft iet BrU 4 High-ft iet BrU 6 High-ft iet BrU Lin - Lin - : C34 + : C9 + 1 1 3 1 4 1 5 C45 1 C34 1 1 1 1 3 1 4 1 5 S-1
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doi: 1.138/nture862 humn hr. 21q MRPL39 murine Chr.16 Mrpl39 Dyrk1A Runx1 murine Chr. 17 ZNF295 Ets2 Znf295 murine Chr. 1 COL18A1 -/- lot: nti-dscr1 IgG hevy hin DSCR1 DSCR1 expression reltive to hevy
Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome
correction notice Nt. Med. 17, 726 731 (2011) Defective Wnt-dependent cereellr midline fusion in mouse model of Jouert syndrome Mdeline A Lncster, Dipik J Gopl, Joon Kim, Shr N Sleem, Jennifer L Silhvy,
Alimonti_Supplementary Figure 1. Pten +/- Pten + Pten. Pten hy. β-actin. Pten - wt hy/+ +/- wt hy/+ +/- Pten. Pten. Relative Protein level (% )
Alimonti_Supplementry Figure 1 hy 3 4 5 3 Neo 4 5 5 Proe 5 Proe hy/ hy/ /- - 3 6 Neo β-tin d Reltive Protein level (% ) 15 1 5 hy/ /- Reltive Gene Expr. (% ) 15 1 5 hy/ /- Supplementry Figure 1 Chrteriztion
nestin ironetin p75 s1 CNS SKPs Dermo-1 +ve SKPs CNS H2O SCGs Skin Di. SKPs TH SHOX2 GAPDH NCAM D H Figure S1, Immunoytohemil nlysis o SKP spheres ulture rom neontl mouse (nestin, ironetin, S-1) or rt
Supplementary Figure S1_Cottini
Supplementry Figure S1_Cottini γ-h2a.x Krp OCIMy5 KMS11 Krps62 RPMI8226 INA6-1 µm Cleve C3 γ-h2a.x DAPI Merge OCIMy5 H929 JJN3 UTMC2 KMS11 KMS12PE KMS18 KMS2 RPMI8226 INA6 U266 KMS34 Krps62 1 2 3 4 5 6
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DOI:.38/n83 k Mouse Ch8 lous 8 9 Stop CHD8L 75 CHD8L Chromoomins Helise/ATPse omin DNA ining omin 5 kd NIH 3T3 MEF 93T HeL HCT UOS SOS.. CHD8L IB: CHD8 8 5 L S Reltive mrna mount 3... Reltive mrna mount.8.
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DOI: 1.138/n2977 Numer of ells per field 6 4 2 P =.1 Orthotopi eum Normlized ventrl photon flux 1E7 1E6 1E5 1E4 1E3 1E2 n=8 n=9 1 2 3 4 5 6 Dys Dy54 1.5E5 2.4E7 d Mie with lymph node metstsis (%) 1 8 6
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2 weeks high holesterol diet 2 weeks high holesterol diet 2 weeks high holesterol diet 2 μm Mrophges Crystls Hoehst μm Mrophges Crystls Hoehst Hoehst Crystls Mrophges 2 μm 2 μm Supplementry Fig. 1: Erly
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DOI: 1.13/n7 Reltive Pprg mrna 3 1 1 Time (weeks) Interspulr Inguinl Epididyml Reltive undne..1.5. - 5 5-51 51-1 1-7 7 - - 1 1-1 Lipid droplet size ( m ) 1-3 3 - - - 1 1-1 1-1 1-175 175-3 3-31 31-5 >5
LHb VTA. VTA-projecting RMTg-projecting overlay. Supplemental Figure 2. Retrograde labeling of LHb neurons. a. VTA-projecting LHb
SUPPLEMENTARY INFORMATION Supplementl Figure 1 doi:10.1038/nture09742 Lterl 1.0 mm from midline mpfc BNST mpfc BNST Lterl 2.1 mm from midline LHA LHA Lterl 2.7 mm from midline SUPPLEMENTAL INFORMATION
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DOI:./n BJ RAS:ER Herrnz et l Supplementry Figure HFFF RAS:ER.. mrna Expression..... ILα ILβ IL IL CCL INH VEGF mrna Expression..... ILα ILβ IL IL CCL INH VEGF + OHT Torin NVP-BEZ + OHT shmtor. shmtor.
DOI: 10.1038/nc2331 PCre;Ros26R 12 h induction 48 h induction Vegfr3 i EC c d ib4 24 h induction VEGFR3 e Fold chnge 1.0 0.5 P < 0.05 Vegfr3 i EC Vegfr3 Figure S1 Cre ctivtion leds to genetic deletion
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doi:.8/nture98 : hr NEMO :5 hr IKK IKK NF-κB p65 p5 p65/-rel NF-κB p65 p5 p65/-rel Cytoplsm Cytoplsm p65/p5 Nuleus Nuleus NEMO IKK IKK d : hr > : hr p65/-rel NF- p65 p5 Cytoplsm Cytoplsm p65/p5 p65/-rel
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DOI:.3/n95 Thymus Kiney (kd) TA T7 T TA T7 T Hert TA T7 T: +Dox Cylin B (kd) Thymus Kiney Hert TA T5 T TA T5 T TA T5 T: +Dox Cylin B Poneu S Poneu S CnB T7 CnB T Thymus (kd) + Liver Colon + + (kd) Thymus
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DOI: 1.138/n358 TLR2 nd MyD88 expression in murine mmmry epithelil supopultions. CD24 min plus MRU Myo-epithelil Luminl progenitor (CD61 pos ) Mture luminl (CD61 neg ) CD49f CD61 Reltive expression Krt5
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Supplementary Figure 1. Scheme of unilateral pyramidotomy used for detecting compensatory sprouting of intact CST axons.
() BDA 2 weeks fter Py () AAVs Cre or GFP t P1 BDA 2 weeks fter Py CSMN CST () Py t P7 or 2 months () Py t 2 months Supplementry Figure 1. Sheme of unilterl pyrmidotomy used for deteting ompenstory sprouting
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oi:1.138/nture1138 Supplementl Figure 1 Inflmmtory Monoytes Host ells CCR2 CCL2 Disseminting Tumor Cells Metstsis Assoite Mrophges VEGF Extrvstion & Metstti Seeing Supplementl Figure 1 The t from this
Supplementary Figure S1
Supplementry Figure S1 - UTR m - 3HA - 2-1 hgh - 1 Uiquitin *! *! lk distl promoter m K3R/ K121R-3HA UTR hgh founder lines - HA - - founder lines TG- E1 L A2 B1 F9 G6 H4 H6 B C D2 G1 H3 J2 L - 7 IP: lk
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Supplementary Figure S1
Supplementry Figure S Connexin4 TroponinI Merge Plsm memrne Met Intrcellulr Met Supplementry Figure S H9c rt crdiomyolsts cell line. () Immunofluorescence of crdic mrkers: Connexin4 (green) nd TroponinI
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Prentl doi:.8/nture57 Figure S HPMECs LM Cells Cell lines VEGF (ng/ml) Prentl 7. +/-. LM 7. +/-.99 LM 7. +/-.99 Fold COX induction 5 VEGF: - + + + Bevcizum: - - 5 (µg/ml) Reltive MMP LM mock COX MMP LM+
Supplementary Information
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Supplementary Figure S1
Supplementry Figure S1 d MAP2 GFAP e MAP2 GFAP GFAP c f Clindin GFAP Supplementry Figure S1. Neuronl deth nd ltered strocytes in the rin of n ffected child. Neuron specific MAP2 ntiody stining in the hippocmpus
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doi:1.138/nture1794 BR EPFs BRI1? ERECTA TMM BSKs YDA PP2A BSU1 BIN2 pbzr1/2 BZR1/2 MKK4/5/7/9 MPK3/6 SPCH Cell growth Stomtl production Supplementry Figure 1. The model of BR nd stomtl signling pthwys.
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100 μm. Axon growth cones. Tubulin (red) + scr (green)
Supplementary Figures mirorna-9 regulates axon extension an ranhing y targeting Map1 in mouse ortial neurons Dajas-Bailaor, F., Bonev, B., Garez, P., Stanley, P., Guillemot, F., Papalopulu, N. a 2 μm 1
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Supplementary Figure 1
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X p -lu c ct ivi ty doi:.8/nture8 S CsA - THA + DAPI Merge FSK THA TUN Supplementry Figure : A. Ad-Xp luc ctivity in primry heptocytes exposed to FSK, THA, or TUN s indicted. Luciferse ctivity normlized
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Supplemental Figures and Legends
Supplementl Figures n Legens Epigeneti trgeting of Hegehog trnsriptionl output through BET romoomin inhiition Yujie Tng 1,2, Shrreh Gholmin 2, Simone Shuert 1,2, Mine I. Willrson 3, Alex Lee 4, Prtiti
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doi: 10.1038/nture07679 Emryonic Stem (ES) cell Hemngiolst Flk1 + Blst Colony 3 to 3.5 Dys 3-4 Dys ES differentition Sort of Flk1 + cells Supplementry Figure 1. Chrcteristion of lst colony development.
NappHS. rrna. transcript abundance. NappHS relative con W+W 0.8. nicotine [µg mg -1 FM]
![NappHS. rrna. transcript abundance. NappHS relative con W+W 0.8. nicotine [µg mg -1 FM]](/thumbs/92/110177253.jpg "NappHS. rrna. transcript abundance. NappHS relative con W+W 0.8. nicotine [µg mg -1 FM]")
(A) W+OS 3 min 6 min con L S L S RNA loding control NppHS rrna (B) (C) 8 1 k NppHS reltive trnscript undnce 6 4.5 *** *** *** *** 3 k. + + + line 1 line (D) nicotine [µg mg -1 FM] 1..8.4. con W+W Supplementl
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DOI: 10.1038/nc2824 Hcn4 Tx5 Mlc2 c Hcn4- ISH d Tx5- ISH e Mlc2-ISH Hcn4-ISH f e Tx5-ISH f -ISH Figure S1 Section in situ hyridistion nlysis of crescent stge mouse emryos (E7.5). () More nterior section
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oi:1.138/nture1134 CS+ CS- MCH 3 OCT OCT 3 MCH CS- CS+ OCT MCH 3 MCH OCT 3 OCT vs MCH OCT vs MCH ppetitive memory (PI) A 1-1 Unpire onitioning DDC-GAL4/UAS-Trp UAS-Trp/+ -2 MCH OCT OCT MCH sugr OCT MCH
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AMPK maintains energy homeostasis and survival in cancer cells via. regulating p38/pgc-1α-mediated mitochondrial biogenesis
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DOI: 10.1038/nc2089 H3K4me1 H3K4me1 H3K4me1 H3K4me1 H3K4me1 H3K4me1 5 PN N1-2 PN H3K4me1 H3K4me1 H3K4me1 2-cell stge 2-c st cell ge Figure S1 Pttern of loclistion of H3K4me1 () nd () during zygotic development
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N6-methyladenosine (m6a) is the most prevalent messenger
https://oi.org/8/s556-8-7- m 6 A mrna methyltion regultes tivity to promote the prolifertion n tumorigeniity of enometril ner Jun Liu,,, Mrk A. Ekert,, Bryn T. Hr,,, Song-Mei Liu,, Zhike Lu,, Kngkng Yu,,5,
Fates-shifted is an F box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos
ARTICLES Ftes-shifted is n F ox protein tht trgets Bioid for degrdtion nd regultes developmentl fte determintion in Drosophil emryos Juno Liu 1 nd Jun M 1,2,3 Bioid (Bd) is morphogeneti protein tht instruts
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DOI:.38/nc393 Nnog DAPI Nnog/DAPI c-jun DAPI c-jun/dapi c e Reltive expression to Gpdh mescs ( Feeder free) mescs ( Feeder) MEFs.5 MEFs ipscs ESCs..5 p=.24 p=.483 p=.22. JunB JunD Fos Fr Fr2 ATF2 ATF3
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regulates stem cells through Wnt/β-catenin signalling
LETTERS O regultes stem ells through Wnt/β-tenin signlling Jolly Mzumdr,,7, W. Timothy O Brien, Rndll S. Johnson, Joseph C. LMnn, Jun C. Chvez 5, Peter S. Klein nd M. Celeste Simon,, Stem ells reside in
% cells forming Neurospheres 81 ± 6 % 0 % 2.6 ± 0.7 % 76 ± 8 % 0 % 3.4 ± 0.6 % 83 ± 5 % 0 % 2.4 ± 0.9 % 89 ± 5 % 3 ± 1.5 % Total 10, ± 6 % 0 %
Bo et l., Suppl. Tle 1 Supplementl Tle 1. Neurosphere formtion nd tumorigencity is enriched within the tumour cell popultions derived from humn primry glioms nd gliom xenogrfts. GBM smples or Gliom xenogrfts
Supplementary Figure 1
doi: 1.138/nture6188 SUPPLEMENTARY INFORMATION Supplementry Figure 1 c CFU-F colonies per 1 5 stroml cells 14 12 1 8 6 4 2 Mtrigel plug Neg. MCF7/Rs MDA-MB-231 * * MCF7/Rs-Lung MDA-MB-231-Lung MCF7/Rs-Kidney
Copy Number ID2 MYCN ID2 MYCN. Copy Number MYCN DDX1 ID2 KIDINS220 MBOAT2 ID2
Copy Numer Copy Numer Copy Numer Copy Numer DIPG38 DIPG49 ID2 MYCN ID2 MYCN c DIPG01 d DIPG29 ID2 MYCN ID2 MYCN e STNG2 f MYCN DIPG01 Chr. 2 DIPG29 Chr. 1 MYCN DDX1 Chr. 2 ID2 KIDINS220 MBOAT2 ID2 Supplementry
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doi:1.138/nture17 Men tumour dimeter (mm) 2 Rg2-/- 2 1 2 2 1 Control IgG!-CD8!-CD4 1 2 3 1 2 3 c Men tumour dimeter (mm) 2 2 1 d Ifnr1-/- Rg2-/- 2 2 1 Ifngr1-/- d42m1!ic 1 2 3 Dys post trnsplnt 1 2 3 Supplementry
Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models
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ARTICLE NUMBER: 164 DOI: 1.138/NMICROBIOL.216.4 MERS coronvirus induces poptosis in kidney nd lung y upregulting Smd7 nd FGF2 Mn-Lung Yeung, Ynfeng Yo, Lilong Ji, Jsper F. W. Chn, Kwok-Hung Chn, Kwok-Fn
Roquin binds inducible costimulator mrna and effectors of mrna decay to induce micrornaindependent post-transcriptional repression
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Dietologi (213) 56:1174 1182 DOI 1.17/s125-13-2835-y ARTICLE Role of the EGF reeptor in PPARγ-meite soium n wter trnsport in humn proximl tuule ells S. S & J. Zhng & R. Yong & D. Yghoin & M. G. Wong &
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SUPPLEMENTARY INFORMATION doi: 1.138/nnno.211.41 Sili nd titnium dioxide nnoprtiles use pregnny omplitions in mie Kohei Ymshit, Ysuo Yoshiok, Kzum Higshisk, Kzuy Mimur, Yuki Morishit, Mstoshi Nozki, Tokuyuki
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doi:10.1038/nture10754 Supplementry note 1 To ompre our dt with previous studies, we mesured the width of spikes from identified dopminergi neurons nd unidentified neurons from DATCre mie. Previous studies
Supplementary figure 1
Supplementry figure 1 Dy 8 post LCMV infection Vsculr Assoc. Prenchym Dy 3 post LCMV infection 1 5 6.7.29 1 4 1 3 1 2 88.9 4.16 1 2 1 3 1 4 1 5 1 5 1.59 5.97 1 4 1 3 1 2 21.4 71 1 2 1 3 1 4 1 5 1 5.59.22
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doi:.38/nture277 d 25 25 2 Time from sound onset (ms) 25 25 2 Time from sound onset (ms) Firing rte (spikes/s) Firing rte (spikes/s).8.6..2 e f g h.8.6..2 Frtion of neurons Frtion of neurons N = 53 2 2
b-sitosterol activates Fas signaling in human breast cancer cells
ARTICLE IN PRESS Phytomeiine 14 (2007) 747 754 www.elsevier.e/phyme -Sitosterol tivtes Fs signling in humn rest ner ells A.B. Aw,, M. Chinnm, C.S. Fink, P.G. Brfor Deprtment of Exerise n Nutrition Sienes
Abortion frequency (%) Ovary position on ear Ovary volume (mm 3 )
ortion frequeny (%) 5 1 Ovry position on er 3 1 WW WD pex Bse Ovry volume (mm 3 ) Figure S1. Ovry volume (thik lines) n ortion frequeny (thin lines) s funtion of position long the er, 15 ys fter silk emergene
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Supplementary Information
Supplementry Informtion Cutneous immuno-surveillnce nd regultion of inflmmtion y group 2 innte lymphoid cells Ben Roediger, Ryn Kyle, Kwok Ho Yip, Nitl Sumri, Thoms V. Guy, Brin S. Kim, Andrew J. Mitchell,
Erucin Exerts Anti-Inflammatory Properties in Murine Macrophages and Mouse Skin: Possible Mediation through the Inhibition of NFκB Signaling
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Supplementary information for: Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage
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doi:.3/nture93 d 5 Rttlesnke DRG (reds) Rttlesnke TG (reds) c 3 TRPV1 other TRPs 1 1 3 Non-pit snke TG (reds) SFig. 1 5 5 3 other TRPs TRPV1 1 1 3 Non-pit snke DRG (reds) 5 Antomy of the pit orgn nd comprison
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SUPPEMENTARY INFORMATION DOI: 1.138/ncb956 Norml CIS Invsive crcinom 4 months months b Bldder #1 Bldder # Bldder #3 6 months (Invsive crcinom) Supplementry Figure 1 Mouse model of bldder cncer. () Schemtic
The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression
Reserh Artile The Hippo/ pthwy interts with EGFR signling nd HPV onoproteins to regulte ervil ner progression Chuno He 1,, Dgn Mo 1,3, Guohu Hu 1,, Xingmin Lv 1, Xingheng Chen, Peter C Angeletti 5, Jixin
LETTER. A restricted cell population propagates glioblastoma growth after chemotherapy
oi:1.138/nture11287 A restrite ell popultion propgtes glioblstom growth fter hemotherpy Jin Chen 1, Ynjio Li 1, Tzong-Shiue Yu 1,2 {, Renée M. MKy 1, Dennis K. Burns 3, Steven G. Kernie 1,2 { & Luis F.
Supplementary Materials. Viral delivery of mir-196a ameliorates the SBMA phenotype via the silencing of CELF2
Supplementry Mterils Virl delivery of mir-96 meliortes the SBMA phenotype vi the silencing of CELF2 Yu Miyzki, Hiroki Adchi, Mshis Ktsuno, Mkoto Minmiym, Yue-Mei Jing, Zhe Hung, Hideki Doi, Shinjiro Mtsumoto,
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doi:10.1038/nture09663 Scrmle shnlrp3 shcsp1 IL-1β (p17) IL-1β (pg/ml) 2000 1500 1000 500 Wt Nlrp3-/- Ipf-/- 0 APDC IL-1β (p17) Supplementl Figure 1. Mitochondril ROS cn trigger NLRP3 inflmmsome ctivtion,
Title of Experiment: Author, Institute and address:
Title of Experiment: Trsfetion of murine mrophge RAW264.7 ells with METAFECTENE PRO. Author, Institute n ress: Ptrizi Pellegtti n Frneso Di Virgilio. Deprtment of Experimentl n Dignosti Meiine, Setion
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RLU Events 1 1 1 Luciferin (μm) T-cells T-ALL 1 1 Time (min) T-cells T-ALL 1 1 1 1 DCF-DA Reltive ATP content....1.1.. T-cells T-ALL RLU 1 1 T-cells T-ALL Luciferin (μm) 1 1 Time (min) c d Control e DCFH-DA
WesternBright Quantum
WesternBright Quntum Quntify hemiluminesent Western lots over wie ynmi rnge WesternBright Quntum is new hemiluminesent regent speilly formulte for CCD imging. This novel Horserish peroxise (HRP) sustrte
INTRODUCTION. Ji-Hye Lee 1, Seon-Mi Yu 1, Eun-Kyung Yoon, Won-Kil Lee, Jae-Chang Jung*, Song-Ja Kim
J Koren Me Si 27; 22: 89-7 ISSN -8934 Copyright The Koren emy of Meil Sienes 2,4 5-Deoxy- -ProstglninJ2 Regultes Deifferentition through Peroxisome Prolifertor-tivte Reeptor- -Depenent Pthwy ut Not Expression
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DOI: 1.138/nc286 Figure S1 e f Medium DMSO AktVIII PP242 Rp S6K1-I Gr1 + + + + + + Strvtion + + + + + IB: Akt-pT38 IB: Akt K-pT389 K IB: Rptor Gr1 shs6k1-a shs6k1-b shs6k1-c shrictor shrptor Gr1 c IB:
FAK integrates growth-factor and integrin signals to promote cell migration
integrtes growth-ftor nd integrin signls to promote ell migrtion rtiles Dvid J. Sieg*, Christof R. Huk*, Dusko Ili, Cndie K. Klingeil*, Erik Shefer, Croline H. Dmsky nd Dvid D. Shlepfer* *Deprtment of
Effects of exercise training on hepatic steatosis in high fat diet-induced obese mice
Effets of exerise trining on hepti stetosis in high ft diet-indued oese mie Hyunsik Kng, PhD Sungkyunkwn University Non-Aloholi Ftty Liver Disese (NAFLD) A reversile ondition tht is hrterized y hepti lipid
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doi:1.138/nture1228 Totl Cell Numer (cells/μl of lood) 12 1 8 6 4 2 d Peripherl Blood 2 4 7 Time (d) fter nti-cd3 i.p. + TCRβ + IL17A + cells (%) 7 6 5 4 3 2 1 Totl Cell Numer (x1 3 ) 8 7 6 5 4 3 2 1 %
LETTER. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
doi:.8/nture98 Impired hydroxyltion of -methylytosine in myeloid ners with mutnt TET Myunggon Ko {, Yun Hung {, Ann M. Jnkowsk, Utz J. Ppe,, Mmt Thilini, Hozef S. Bndukwl, Jungeun An {, Edwrd D. Lmperti,
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doi:0.08/nture078 RNse VifHA VifHA βctin 6 Cell lyste IP: ntiha MG VifHA VifHA β ctin 6 7 Cell lyste IP: ntiha Supplementry Figure. Effect of RNse nd MG tretment on the Vif interction., RNse tretment does
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. Norml Physiologicl Conditions. SIRT1 Loss-of-Function S1. Model for the role of SIRT1 in the regultion of memory nd plsticity. () Our findings suggest tht SIRT1 normlly functions in coopertion with YY1,
Control vector. HA-Elfn2. HA-Elfn1
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Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells
Reeive 27 Mr 215 Aepte 25 My 215 Pulishe 2 Jul 215 DOI: 1.138/nomms8629 Frnesoi X reeptor inhiits glugon-like peptie-1 proution y enteroenorine L ells Mohme-Smi Trelsi 1,2,3,4, Mehi Doui 1,2,3,4, Jnne
Provider How To. Software Process Service Results
Softwre Proess Servie Results Provier How To Copyright Glenwoo Systems LLC 2010. The informtion herein remins the property of Glenwoo Systems LLC. This informtion my not e reprinte or uplite, n is governe
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doi:10.1038/nture09973 Plsm Memrne Phgosome TLR1/2/4 ROS Mitochondrion ROS OXPHOS Complex I ROS TRAF6 NADPH Oxidse Supplementry Figure 1 Model detiling the roles of mitochondril ROS in mcrophge cteril