Objectives. Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions. Case 1. Dengue Introduction 10/15/2018
|
|
- Gordon Smith
- 5 years ago
- Views:
Transcription
1 Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions Wayne Ghesquiere MD FRCPC Infectious Diseases Consultant Clinical Assistant Prof, UBC Victoria, BC Objectives Discuss common Arbovirus infections Dengue Chikungunya Japanese Encephalitis Zika Virus Case presentations Learn some medicine Have fun Case 1 62 year male returns from Puerto Vallarta, Mexico where he been on vacation for 3 weeks Two days prior to leaving he has fatigue and fever He returned home 5 days ago, now he has headaches, rash on his trunk and extremities, His major complaint is muscle pains Dengue Introduction Dengue is also known as Breakbone fever Mortality is 1-5% without treatment With adequate treatment <1% Severe disease carries a mortality of 26% Dengue is endemic in over 110 countries worldwide Dengue Map CDC: Distribution and Outbreaks (Past 6 months) Dengue Cases in the America
2 Dengue Dengue fever virus (DENV) is an RNA virus of the family Flaviviridae: genus Flavivirus Most are transmitted by arthropods (mosquitoes or ticks) and are therefore referred to as arboviruses (arthropodborne viruses) Dengue- Serotypes There are four TYPES of virus which are called serotypes and these are referred to as DENV-1, DENV-2, DENV-3, DENV-4 Hence you can get dengue multiple times All four serotypes can cause the full spectrum of disease Infection with one serotype is believed to produce lifelong immunity to that serotype but only short term immunity against the others Dengue- Vector Dengue virus is primarily transmitted by Aedes mosquitoes particulaily A. aegypti yet also seen in A. albopictus These mosquitoes usually live between the latitudes of 35 N and 35 S below the elevation of 1000 meters (3300 ft.). They bite primarily during the day, around your ankles and knees Humans are the primary host but it also circulates in nonhuman primates Dengue Incubation period is 3-12 days from bite to the onset of symptoms This is very important especially when sorting out the cause of Fever in the Returning Traveller The virus is not contagious and cannot be spread from person to person It s an acute illness of sudden onset that usually follows a benign course with symptoms such as headache, fever, exhaustion, severe muscle and joint pains, Lymphadenopathy Rash Clinical Symptoms Clinical Signs 2
3 Laboratory Diagnosis Lymphopenia Thrombocytopenia Serology for Dengue IgM and IgG If there is a decrease in Hgb and albumin then this is a severe case i.e. DHF Treatment or Prevention There is no antiviral therapy for Dengue There is no tested and approved vaccine Treatment consists of symptomatic control and support with close monitoring of lab data and vitals Watch for the development of DHF Update: Lancet Feb 2018 However, after reassessment of data from the clinical trials, Sanofi warned on Nov 29, 2017, that the vaccine can increase the risk of severe dengue in patients who have never had Dengue. Studies have shown that giving the vaccine to people who have never been infected before can leave them vulnerable to a severe reaction if they are subsequently infected. WHO April 19, recommended it only be used in people who have previously been infected with the disease. Symptoms Dengue HF Lab Findings Thrombocytopenia Anemia Neutropenia Differential Diagnosis Case 2 Malaria Chikungunya Leptospirosis Typhoid fever Meningococcal disease Other viral infections, Parvovirus B19, Measles, EBV, CMV, HIV Drug fever A 56 year old female presents to you with an acute illness She was in Jamaica for two weeks on vacation. Upon returning home, seven days ago, she got fever, headache, rash on her legs and now has swollen and tender ankles and wrists 3
4 Case 2 What further info would you like to know? Lab Platelets 100 ( ) WBC 4.9 with lymphopenia CRP 100 Mosquito vectors Predominantly Aedes aegypti and Aedes albopictus Same mosquitoes that transmit dengue Widely distributed throughout the World Aggressive daytime biters Aedes aegypti Aedes albopictus Chikungunya virus infection Majority (72%-92%) of infected people develop clinical symptoms Incubation period usually 3-7 days (range 1-12 days) Primary clinical symptoms are fever and polyarthralgia Fever and Polyarthralgia Fever Abrupt onset Typically >39.0 C Joint pain Often severe and debilitating Involves multiple joints Usually bilateral and symmetric Most common in hands and feet Other Clinical Signs & Symptoms Headache Myalgia Arthritis Conjunctivitis Nausea/vomiting Maculopapular rash Clinical Lab Findings Lymphopenia Thrombocytopenia Elevated creatinine Elevated liver enzymes- ALT, AST 4
5 Clinical Outcome Acute symptoms typically resolve in 7-10 days Mortality is rare Some patients have relapse or persistent rheumatologic symptoms for months or years Polyarthragia, Polyarthritis Tenosynovitis Raynaud's syndrome Diagnostic Testing Serology for IgM and confirmatory neutralizing antibodies Serology for >4-fold rise in virus-specific quantitative antibodies titers on paired sera Culture of virus or PCR for viral RNA Treatment of Chikungunya No specific antiviral therapy Supportive care with rest and fluids NSAIDS for acute fever and pain Persistent joint pain is the single major problem. Patients may benefit from use of NSAIDs, corticosteroids, hydroychloroquine or physiotherapy. What is Zika Virus Zika is a flavivirus, related to dengue, yellow fever, West Nile and JE Discovered in 1947 in the Zika forest of Uganda Transmitted by Aedes mosquitoes Incubation period 3-12 days 5
6 Zika Clinical Symptoms occur in 20-25% of infections Fever, rash, arthralgia, conjunctivitis, HA x~1 week GBS recognized in French Polynesia Virus detected in serum and saliva for ~7 d urine for ~10 d, semen for >60 days ZIKV Diagnosis Diagnosed by RT-PCR or serology IgM Serology is a pan-flavivirus done at BCCDC Serology is not 100% accurate No treatment or vaccine available Why is Zika a Problem Huge increase (>20 fold) in microcephaly coinciding with Zika outbreak in Brazil >1.5 M Zika infections since Feb 2015 >5000 cases microcephaly in Brazil Associations also reported in Latin America Zika and Fetus Anomalies Several affected fetuses/infants positive for Zika in brain, CSF Viral loads in amniotic fluid 4 logs higher than in blood of acutely infected adults Ocular involvement, hydrops, fetal death Pregnancy Outcomes after ZIKA Infection in French Territories in the Americas Hoen et al NEJM, March 15, 2018 Among pregnant women, PCR confirmed ZIKA infection, birth defects were present in 7% Defects were more likely if infection was early in pregnancy 1 st trimester 12.7% 2 nd trimester 3.6% 3 rd trimester 5.3% Zika Virus Shedding in Semen of Symptomatic Infected Men Mead et al, NEJM, April12, 2018 Conclusion ZIKA RNA was commonly present in the semen of men with symptomatic ZIKA infection and persisted for > 6 months Shedding of infectious ZIKA appeared to be much less ie <1 month 6
7 Persistence of Zika Virus in Body Fluids Final Report NEJM, Sept 27, 2018 In 95% of the men in this study, ZIKV RNA was cleared from semen after approximately 4 months. Answers to Common Questions Q: How long should you wait to try to become pregnant after traveling to an area with Zika? A: Women who have had symptoms of the virus or tested positive for it should wait at least eight weeks after their symptoms first appeared before trying to get pregnant, Men- Canada recommended that men who had symptoms should wait 6 months before having unprotected sex. Yet CDC in USA states 3 months (Updated August 2018) Common questions about Zika Q: Is the Zika test accurate? A: Asymptomatic patients: Routine testing is not currently recommended for nonpregnant women and men who have possible exposure to Zika virus but no clinical illness. No test is 100% accurate Questions about Zika Q: Do travellers who do not plan on conceiving need to be worried about Zika virus infection? A: Symptoms consist of fever, rash, arthralgia, conjunctivitis, HA x~1 week and a low risk of Guillain Barre Syndrome Can you get Infected in Canada with Zika Virus? Zika Virus infection is not acquired in Canada. The mosquitos that transmit Zika Virus and Dengue do not exist in Canada due to the climate. Canadian Results CMAJ March 6, 2017 Over 1 year- Oct 2015-Sept visits to CanTravNet sites 41 patients (3.7%) with Zika Dx & 41 with Dengue. First half of the period primarily from VFRs to South America Second half from tourists to the Caribbean Islands 7
8 Canadian Data 40 patients from Mosquito bites One from sexual transmission Congenital transmission occurred in 2 of 3 pregnancies. Two (5%) of those with Zika had symptoms resembling those of Guillain Barré syndrome, 1 of whom also had Zika viral meningitis. Summary Dengue On the rise throughout the world especially in South and Central America and Caribbean Incubation period 2-12 days Associated with fever, rash, reduced WBC & platelets, No vaccine for travellers, Travellers need to use DEET and personal protection measures Summary Chikungunya Seen throughout the world yet decreased incidence especially in the Caribbean Fever, rash and significant almost debilitating polyarthralgia, associated with decreased WBC and Platelets No Vaccine Travellers need to use DEET and personal protection measures Summary Zika Virus Reduced incidence in South and Central America and Caribbean Associated with fever and rash yet 70% of patients who get infected have minimal to no symptoms. Birth defects can occur if infection during pregnancy ~3.4-12% incidence Women who visit endemic areas should not conceive for 8 weeks, Men should not conceive for 3-4 months (CDC) but 6 months may be safer ( Health Canada) 8
Public Health Image Library. CDC/ Cynthia Goldsmith. Image #
Zika Virus Fredrick M. Abrahamian, D.O., FACEP, FIDSA Clinical Professor of Medicine UCLA School of Medicine Director of Education Department of Emergency Medicine Olive View-UCLA Medical Center Sylmar,
More informationWhen infections go viral Zika Virus
When infections go viral Zika Virus John Fangman, MD Associate Professor of Medicine (Infectious Diseases) Senior Medical Director of Ambulatory, Medical College Physicians Medical College of Wisconsin
More informationZika Virus. ZIKA VIRUS & PREGNANCY Stephen Champlin, M.D. FLAVIVIRIDAE VIRUS SPECTRUM. Virus family Flaviviridae
ZIKA VIRUS & PREGNANCY Stephen Champlin, M.D. Zika Virus Virus family Flaviviridae Positive sense, single-stranded RNA virus FLAVIVIRIDAE VIRUS SPECTRUM Arbovirus - spread by arthropods to mammals Flaviviridae
More informationZIKA VIRUS. John J. Russell MD May 27, 2016
John J. Russell MD May 27, 2016 HISTORY Discovered 1947 Zika Forest of Uganda in rhesus monkeys, thus the name Found in humans in Africa in 1952 Not considered a public health threat until outbreak in
More informationWhat s Lurking out there??????
What s Lurking out there?????? Dave Warshauer, PhD, D(ABMM) Deputy Director, Communicable Diseases Wisconsin State Laboratory of Hygiene david.warshauer@slh.wisc.edu WISCONSIN STATE LABORATORY OF HYGIENE
More informationZika Virus: The Olympics and Beyond
Zika Virus: The Olympics and Beyond Alice Pong, MD Pediatric Infectious Diseases Rady Children s Hospital-San Diego University of California, San Diego Disclosures I have no disclosures to report 1 Objectives
More informationZika Virus Update for Emergency Care Providers
Zika Virus Update for Emergency Care Providers What is this Zika Virus? Jeff Doerr Epidemiologist Southeastern Idaho Public Health Zika Virus Single stranded RNA virus Genus Flavivirus, Family Flaviviridae
More informationZika Virus. Centers for Disease Control and Prevention
Centers for Disease Control and Prevention Zika Virus Ingrid Rabe Medical Epidemiologist Arboviral Diseases Branch Centers for Disease Control and Prevention February 1, 2016 Zika Virus Single stranded
More informationZika Virus. Maternal & Fetal Effects. John P. Elliott, MD Medical Director, Valley Perinatal Services Phoenix, Arizona
Zika Virus Maternal & Fetal Effects John P. Elliott, MD Medical Director, Valley Perinatal Services Phoenix, Arizona Objective of Presentation Sneeka Peeka at Zika Disclosure I have nothing to disclose
More informationTHE ZIKA VIRUS. August 3, Sonia G. Pandit, MPH MBA Chief Executive Officer The Pandit Group
THE ZIKA VIRUS August 3, 2016 Sonia G. Pandit, MPH MBA Chief Executive Officer The Pandit Group sonia@thepanditgroup.com 443-990-1372 www.thepanditgroup.com What Makes Zika Unique? Viral disease (Flavi
More informationZIKA VIRUS OUTBREAK. JANET B. EDDY M.D. KU-WICHITA PGY2 OBSTETRICS AND GYNECOLOGY RESIDENCY Dominican Republic 2016
ZIKA VIRUS OUTBREAK JANET B. EDDY M.D. KU-WICHITA PGY2 OBSTETRICS AND GYNECOLOGY RESIDENCY Dominican Republic 2016 Zika time line 1947: 1 st isolated in rhesus monkey in Zika forest of Uganda 1 12/2013:
More informationEverything you ever wanted to know about Zika Virus Disease
Everything you ever wanted to know about Zika Virus Disease (in 14 slides) Jon Temte, MD/PhD University of Wisconsin School of Medicine and Public Health 28 January 2016 Zika Virus mosquito-borne flavivirus
More informationZika: Deet, There It Is. Anna Powell, MD Reproductive Infectious Disease Fellow THEGOS
Zika: Deet, There It Is Anna Powell, MD Reproductive Infectious Disease Fellow THEGOS Disclosure I have no financial disclosures or conflicts of interest Lessons from Rubella At peak of rubella epidemic
More informationZika. Nicole Evert, MS Zoonosis Control Branch Department of State Health Services Austin, Texas
Zika Nicole Evert, MS Zoonosis Control Branch Department of State Health Services Austin, Texas Family Flaviviridae, genus Flavivirus Vectors: Aedes aegypti and Aedes albopictus Maintained in a human-mosquito-human
More informationZika Virus and Control Efforts in Arizona
Zika Virus and Control Efforts in Arizona Irene Ruberto, MPH, PhD Epidemiologist Office of Infectious Disease Services Arizona Department of Health Services November 10, 2016 Goal by Humbletree (cc by-nc
More informationZika Virus. Lee Green Vector-Borne Epidemiologist Indiana State Department of Health. April 13, 2016
Zika Virus Lee Green Vector-Borne Epidemiologist Indiana State Department of Health April 13, 2016 What Is It? Flavivirus WNV Dengue St. Louis Encephalitis Yellow Fever Tick Borne Encephalitis Single stranded
More informationZIKA: is South Africa at risk? Lucille Blumberg National Institute for Communicable Diseases South Africa
ZIKA: is South Africa at risk? Lucille Blumberg National Institute for Communicable Diseases South Africa 18 th April 1947; Rhesus macaque (no 766) with fever Filtrable transmissable agent The absence
More informationUpdates in Infectious Diseases. Kelley Struble, DO, MS St. John Physicians Infectious Disease September 30, 2016
Updates in Infectious Diseases Kelley Struble, DO, MS St. John Physicians Infectious Disease September 30, 2016 Disclosures No financial relationships or affiliations to disclose Overview Activity Pre-Test
More informationZika Virus and Prevention in Mississippi
Mississippi State Department of Health Mississippi Morbidity Report Volume 32, Number 1 July 2016 Background: Zika Virus and Prevention in Mississippi Key Messages: Zika virus infection during pregnancy
More informationOutbreaks of Zika Virus: What Do We Know? Presented by Dr Jonathan Darbro Mosquito Control Lab, QIMR Berhgofer 15 September 2016
Outbreaks of Zika Virus: What Do We Know? Presented by Dr Jonathan Darbro Mosquito Control Lab, QIMR Berhgofer 15 September 2016 Overview History Distribution Modes of Transmission Symptoms Some Causal
More informationThis memo is intended to provide information to NC clinicians and laboratories regarding diagnosis, management and reporting of Zika virus infection.
May 18, 2016 (replaces version dated March 31, 2016) To: From: North Carolina Health Care Providers and Laboratories Megan Davies, MD, State Epidemiologist Scott Zimmerman, DrPH, MPH, HCLD (ABB), State
More informationWhat is Zika virus? What are the symptoms and complications of Zika virus infection? Are cases expected in Canada?
What is Zika virus? Zika Virus Update for Healthcare Professionals Updated June 22, 2016; italicized text indicates clarification of wording contained in previous versions. Zika virus is a Flavivirus transmitted
More informationGeneral Description. Significance
General Description The Zika virus is a member of the Flavivirus family, and is a small, enveloped virus (easy to kill with a hospital disinfectant). Zika virus is an emerging mosquito-borne virus that
More informationEuropean Centre for Disease Prevention and Control. Zika virus disease
European Centre for Disease Prevention and Control Zika virus disease Stockholm, 19 February 2016 Background information Zika virus is a member of the Flaviviridae family and transmitted by mosquitoes
More informationZika Virus Basics. Flaviviridae Flavivirus Disease Vector Vaccine *Dengue (serotypes 1-4) Zika Virus Basics. Zika Virus Transmission Cycle
Zika: Infection,, and Protection Roxanne P. Liles, Ph.D., MLS(ASCP) CM Assistant Professor of Biology Louisiana State University at Alexandria 318-473-6518 rliles@lsua.edu Zika Virus Basics Virion: Enveloped
More informationZika virus: a new global threat for Dr Gina McAllister Clinical Scientist, Virology
Zika virus: a new global threat for 2016 Dr Gina McAllister Clinical Scientist, Virology Moritz U. G. Kraemer and others The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus
More informationZika Virus Dr Conor Doherty
Zika Virus Dr Conor Doherty Zika Virus Single stranded RNA enveloped icosahedral virus Flavivirus (e.g. dengue, yellow feve er) First described in Zika forest in Uganda in 1947 Initial enzootic monkey
More information10/6/2016. Outline. Zika, Dengue, and Chikungunya Viruses in the Americas Oh My! Some Mosquito-Borne Arboviruses
Zika, Dengue, and Chikungunya Viruses in the Americas Oh My! Geoffrey A. Weinberg, M.D., FAAP, FIDSA, FPIDS Professor of Pediatrics Director, Pediatric HIV Program Division of Pediatric Infectious Diseases
More informationEpidemiology and entomology of the Zika virus outbreak
Epidemiology and entomology of the Zika virus outbreak M A T T H E W B A Y L I S I N S T I T U T E O F I N F E C T I O N A N D G L O B A L H E A L T H U N I V E R S I T Y O F L I V E R P O O L Zika in
More informationAn Introduction to Dengue, Zika and Chikungunya Viruses
An Introduction to Dengue, Zika and Chikungunya Viruses Natalie Marzec, MD, MPH Zoonoses Epidemiologist 2017 Global Health and Disasters Course Objectives Arbovirus Overview Public Health Activities Clinical
More informationGuidance for Investigation and Management of Zika Virus Infection
Guidance for Investigation and Management of Zika Virus Infection Update: February 11, 2016 Public Health Agency of Canada has issued recommendations from the Committee to Advise on Tropical Medicine and
More informationZika virus: Interim guidance information for LMCs (midwives), GPs and other health professionals dealing with Zika virus in pregnancy 5 February 2016
Zika virus: Interim guidance information for LMCs (midwives), GPs and other health professionals dealing with Zika virus in pregnancy 5 February 2016 This interim guidance is the result of consultation
More informationGeographic distribution ZIKV
Shelley M. Wood, RN, BSN, CEN March 16, 2016 Geographic distribution ZIKV 1947 2007 http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2819875/ 1 Current Active Zika transmission WHO declared global health threat
More informationWelcome All. Western Australia Oncology Menopause Endometriosis New Mothers
Welcome All Western Australia ZIKA VIRUS What s the latest? Dr Clay Golledge COUNTRIES WITH ONGOING ZIKA CIRCULATION American Samoa Curacao Guyana Nicaragua Tonga Barbados Dominican Republic Haiti Panama
More informationZika virus infection Interim clinical guidance for Primary Care
Zika virus infection Interim clinical guidance for Primary Care Zika virus infection is a notifiable disease in Ireland under the Infectious Diseases (Amendment) Regulations 2016 (S.I.. 276 of 2016). All
More informationZika Virus Update. Partner Webinar 05/12/2016
Zika Virus Update Partner Webinar 05/12/2016 Today s presenters Patricia Quinlisk, MD, MPH, Medical Director /State Epidemiologist Ann Garvey, DVM, MPH, MA, State Public Health Veterinarian/ Deputy State
More informationA RELOOK AT ZIKA VIRAL INFECTION AND ITS LATEST OUTBREAK IN INDIA
24 th December 2018 A RELOOK AT ZIKA VIRAL INFECTION AND ITS LATEST OUTBREAK IN INDIA BACKGROUND Zika virus infection, which erupted on a large scale in 2015-2016, has infected more than 1.5 million people.
More informationZIKA VIRUS. Causes, Symptoms, Treatment and Prevention
ZIKA VIRUS Causes, Symptoms, Treatment and Prevention Introduction Zika virus is spread to people through mosquito bites. The most common symptoms of Zika virus disease are fever, rash, joint pain, and
More informationCarol M. Smith, M.D., M.P.H. Commissioner of Health and Mental Health Ulster County Department of Health and Mental Health May 20, 2016
Carol M. Smith, M.D., M.P.H. Commissioner of Health and Mental Health Ulster County Department of Health and Mental Health May 20, 2016 Michael Hein County Executive Zika virus was first discovered in
More informationTravel: Chikungunya, Zika,.. New worries
Travel: Chikungunya, Zika,.. New worries McGill Family Physician Refresher Course Dec 6, 2016 Makeda Semret, MD FRCP(C) Infectious Diseases/ Medical Microbiology Disclosures Funding from PHAC/CIHR/GSK/Novartis
More informationZIKA Jordan H. Perlow MD Banner University Medical Center Division of Maternal Fetal Medicine Phoenix Perinatal Asoociates
ZIKA Jordan H. Perlow MD Banner University Medical Center Division of Maternal Fetal Medicine Phoenix Perinatal Asoociates Disclosures I have no relevant financial relationships to disclose or conflicts
More informationWrapping Our Heads Around the Outbreak
Wrapping Our Heads Around the Outbreak An Update on the Zika Virus P. Zach White, PharmD PGY1 Pharmacy Resident Mayo Eugenio Litta Children s Hospital Pharmacy Grand Rounds June 7, 2016 2015 MFMER slide-1
More informationZika Virus. Robert Wittler, MD
Zika Virus Robert Wittler, MD Disclosure I have no relevant financial relationships with the manufacturers(s) of any commercial products(s) and/or provider of commercial services discussed in this CME
More informationZika Virus. Disclosure. Zika Virus 8/26/2016
Zika Virus Robert Wittler, MD Disclosure I have no relevant financial relationships with the manufacturers(s) of any commercial products(s) and/or provider of commercial services discussed in this CME
More informationFIRST CONFIRMED CASE OF IMPORTED ZIKA VIRUS IN HOUSTON, TEXAS. Preventing Transmission
FIRST CONFIRMED CASE OF IMPORTED ZIKA VIRUS IN HOUSTON, TEXAS Preventing Transmission Objectives Discuss the epidemiology of Zika virus Describe the Zika case investigation of the first confirmed case
More informationFocus. International #57. Dengue Fever, Chikungunya and the Zika Virus. Chikungunya
Dengue Fever, Chikungunya and the Zika Virus Arboviruses are a group of virus that can be transmitted between animals and humans, and they are common to humans and many vertebrates (mammals, birds, reptiles,
More informationZIKA VIRUS. Epic and aspects of management
ZIKA VIRUS Epic and aspects of management Classification - Belong to the family Flaviviridae which are mosquitoes borne viruses such as Dengue virus ( DEN V ), West Nile virus ( WN V ), Yellow fever Virus
More informationVector-Borne Diseases Update: Maricopa County
Vector-Borne Diseases Update: Maricopa County Craig Levy, Epizoologist, Office of Epidemiology WeArePublicHealth.org twitter.com/maricopahealth facebook.com/mcdph Emerging Arboviruses Zika Virus Chikungunya
More informationThe Zika Crisis: Where, What and USG/WHO? Brian R. Moyer BRMoyer & Associates, LLC Bedford, NH
2016 National Biotechnology Conference, Boston, May 18th The Zika Crisis: Where, What and USG/WHO? Brian R. Moyer BRMoyer & Associates, LLC Bedford, NH 03110 bmoyernh@gmail.com 2016 National Biotechnology
More informationModule Three About Zika Virus: What is Known and Not Known
Module Three About Zika Virus: What is Known and Not Known HOUSEKEEPING For educational and quality improvement purposes, this TeleECHO Clinic will be recorded By participating in this clinic, you are
More informationZika Virus. Division of Infectious Disease Department of Internal Medicine Global Health Program Conference Dora Lebron, MD Alexandra Stang, MD
Zika Virus Division of Infectious Disease Department of Internal Medicine Global Health Program Conference Dora Lebron, MD Alexandra Stang, MD Zika Virus ZIKV is a mosquito-borne ssrna flavivirus from
More informationZika Virus Outbreak in the Americas. J. David Beckham MD Associate Professor of Medicine Division of Infectious diseases University of Colorado SOM
Zika Virus Outbreak in the Americas J. David Beckham MD Associate Professor of Medicine Division of Infectious diseases University of Colorado SOM Learning Objectives Understand the pathogenesis of West
More informationKILLER BITES: Mosquito-Borne Viruses Jon Mark Hirshon, MD, MPH, PhD
KILLER BITES: Mosquito-Borne Viruses Jon Mark Hirshon, MD, MPH, PhD Professor, Department of Emergency Medicine University of Maryland School of Medicine Disclosures Conflicts of Interest: Pfizer consultant
More informationZIKA VIRUS. Annanya Gangopadhyay*, Shubhrajit Mantry, Abhinay Chhetri, Sudip das
ZIKA VIRUS Annanya Gangopadhyay*, Shubhrajit Mantry, Abhinay Chhetri, Sudip das, Himalayan Pharmacy Institute, Majhitar, Rangpo, E. Sikkim 737136, INDIA ARTICLE INFO: Article history: Received: 02 December
More informationZika Virus in the Primary Care Setting
Zika Virus in the Primary Care Setting Monica McArthur, MD PhD Assistant Professor of Pediatrics Center for Vaccine Development University of Maryland School of Medicine Maryland Chapter ACP Meeting 17
More informationZika virus: clinical and epidemiological features
Zika virus: clinical and epidemiological features Dominic Dwyer Medical Virologist, Westmead Hospital Director, ICPMR and Pathology West NSW Health Pathology dominic.dwyer@sydney.edu.au, Zika virus Flavivirus
More informationZIKA COLLABORATION MEETING: CLINICAL PERSPECTIVE. Julius L. Tonzel Vector-borne Diseases Epidemiologist Louisiana Office of Public Health
ZIKA COLLABORATION MEETING: CLINICAL PERSPECTIVE Julius L. Tonzel Vector-borne Diseases Epidemiologist Louisiana Office of Public Health DISCLOSURE STATEMENT The speakers, the speakers spouses, and the
More informationThe problem with TORCH screening
: Beyond TORCHeS TORCH or STORCH-a helpful mnemonic? Toxoplasma Other Rubella CMV HSV (HIV) Syphilis 3 The problem with TORCH screening TORCH-first proposed by Nahmias et.al. (Pediatr Res 1971) Toxo, Rubella,
More informationMercer MRC A Newsletter for and about our volunteers
Mercer MRC A Newsletter for and about our volunteers May 2017 Volume 1, Issue 5 Brian Hughes, County Executive Marygrace Billek, Director, Dept. of Human Services Lyme Disease Awareness Month May is Lyme
More informationZika and Emerging Infectious Diseases. Clifford T. Mauriello, MD, FAAP Assistant Clinical Professor May 31, 2016
Zika and Emerging Infectious Diseases Clifford T. Mauriello, MD, FAAP Assistant Clinical Professor May 31, 2016 Famous Last Words The time has come to close the book on infectious diseases. We have basically
More informationPresentation Overview
Presentation Overview Characteristics of Zika virus Characteristics of Zika virus infection Epidemiology and outbreaks Vector and transmission Clinical symptoms Diagnosis and testing Treatment and prevention
More informationZika Virus Guidance for Medical Providers. Denise Smith, PHN, MPA Director of Disease Control Kern County Public Health Services Department
Zika Virus Guidance for Medical Providers Denise Smith, PHN, MPA Director of Disease Control Kern County Public Health Services Department Kern Perinatal Symposium March 3, 2017 CME DISCLOSURE The Planners,
More informationARIZONA ARBOVIRAL HANDBOOK FOR CHIKUNGUNYA, DENGUE, AND ZIKA VIRUSES
ARIZONA ARBOVIRAL HANDBOOK FOR CHIKUNGUNYA, DENGUE, AND ZIKA VIRUSES 7/31/2017 Arizona Department of Health Services P a g e 1 Arizona Arboviral Handbook for Chikungunya, Dengue, and Zika Viruses OBJECTIVES...
More informationClinical Policy: Diagnostic Testing for Zika Virus Reference Number: CP.MP.111 Effective Date: 06/16
Clinical Policy: Diagnostic Testing for Zika Virus Reference Number: CP.MP.111 Effective Date: 06/16 Last Review Date: 05/16 Revision Log See Important Reminder at the end of this policy for important
More informationZika Virus Identifying an Emerging Threat. Florida Department of Health in Miami-Dade County Epidemiology, Disease Control, & Immunization Services
Zika Virus Identifying an Emerging Threat Florida Department of Health in Miami-Dade County Epidemiology, Disease Control, & Immunization Services What is Zika Virus? Zika virus is a vector-borne disease
More informationZika Virus Outbreak An Update and Overview of the New York State Response
Zika Virus Outbreak An Update and Overview of the New York State Response Elizabeth Dufort, MD, FAAP Medical Director Division of Epidemiology New York State Department of Health Zika Virus- The Basics
More informationMosquito Control Update. Board of County Commissioners Work Session February 16, 2016
Mosquito Control Update Board of County Commissioners Work Session February 16, 2016 1 Presentation Overview Mosquito Control Division Mosquito-borne Diseases Control Techniques Outlook 2 Mosquito Control
More informationZika Outbreak Discussion
Zika Outbreak Discussion May 10, 2016 2016 Zurich Healthcare Customer Symposium Speakers Krishna Lynch Senior Healthcare Risk Consultant Zurich Clayton Shoup Business Director, Workers Compensation Zurich
More informationZIKA PRESENTED BY DENNIS QUERTERMOUS, DIANNA HUNTER, MERCEDES RUTLEDGE, AND DRE'ANDRIA THOMPSON
ZIKA PRESENTED BY DENNIS QUERTERMOUS, DIANNA HUNTER, MERCEDES RUTLEDGE, AND DRE'ANDRIA THOMPSON ZIKA OVERVIEW Family: Flaviviridae Genus: Flavivirus Enveloped, single-stranded RNA virus First identified
More informationUPDATE ON ZIKA VIRUS INFECTION
IMPORTANCE UPDATE ON ZIKA VIRUS INFECTION Robert A. Broughton, M.D. Professor of Pediatrics Division of Infectious Diseases E-mail: rbrough@uky.edu WHO declared Zika a Public Health Emergency of International
More informationFY 2017 President s Budget Request Overview for the National Center on Birth Defects and Developmental Disabilities
National Center on Birth Defects and Developmental Disabilities FY 2017 President s Budget Request Overview for the National Center on Birth Defects and Developmental Disabilities Sascha Chaney Associate
More informationZika Virus What Every Woman Needs to Know
Zika Virus What Every Woman Needs to Know Carrie L. Byington, MD The Jean and Thomas McMullin Professor and Dean of Medicine Senior Vice President Health Science Center Vice Chancellor for Health Services
More informationFact Sheet. Zika Virus
Fact Sheet Zika Virus The following provides information on the use and containment of Zika virus (ZIKV). Investigators should use these guidelines as part of their risk assessment when planning experiments
More informationJan Byrne, M.D. Cortesia Maisa Wanderley
Jan Byrne, M.D. University of Utah Maternal-Fetal Medicine Clinical Genetics National Birth Defects Prevention Network Utah Fetal Center at Primary Children s Cortesia Maisa Wanderley Dr. Byrne has no
More informationTown of Wolfeboro New Hampshire Health Notice Wolfeboro Public Health Officer Information Sheet Zika Virus
Aedes Zika Virus Information Sheet Town of Wolfeboro New Hampshire Health Notice Wolfeboro Public Health Officer Information Sheet Zika Virus The Zika Virus is a mosquito borne illness spread by the Aedes
More information*This response is constantly evolving and recommendations in this presentation may change over time, please call your district epidemiologist or a
*This response is constantly evolving and recommendations in this presentation may change over time, please call your district epidemiologist or a GDPH epidemiologist 404-657-2588, 8-5 pm M-F for current
More informationWhat You Need to Know ZIKA VIRUS
What You Need to Know ZIKA VIRUS What is Zika Virus? Zika virus is a flavivirus related to dengue, West Nile, yellow fever and Japanese encephalitis Zika virus first identified in 1947 and named for the
More informationZIKA VIRUS DISEASE: What every clinician should know
11/12/2016 1 ZIKA VIRUS DISEASE: What every clinician should know Francisco García, MD, MPH Director & Chief Medical Officer Objectives Zika virus epidemiology Diagnoses and testing Zika and pregnancy
More informationZika Virus A Public Health Emergency of Olympic Proportions
Zika Virus A Public Health Emergency of Olympic Proportions Carrie L. Byington M.D.** HA and Edna Benning Presidential Professor Division of Pediatric Infectious Diseases ** With Thanks to Andrew Pavia,
More informationARIZONA ARBOVIRAL HANDBOOK FOR CHIKUNGUNYA, DENGUE, & ZIKA VIRUSES
ARIZONA ARBOVIRAL HANDBOOK FOR CHIKUNGUNYA, DENGUE, & ZIKA VIRUSES 3/3/2016 Arizona Department of Health Services P age 1 Arizona Arboviral Handbook for Chikungunya, Dengue, & Zika Viruses OBJECTIVES...
More informationZIKA Virus and Mosquito Management. ACCG Rosmarie Kelly, PhD MPH 30 April 16
ZIKA Virus and Mosquito Management ACCG Rosmarie Kelly, PhD MPH 30 April 16 What is Zika Virus? Zika virus (ZIKV) is a flavivirus related to yellow fever, dengue, West Nile, and Japanese encephalitis viruses.
More informationWhat is Zika virus (Zika)?
Zika Virus Basics What is Zika virus (Zika)? Viral infection caused by the bite of an infected mosquito Linked to serious birth defects and other poor pregnancy outcomes in babies of mothers who were infected
More informationCenters for Disease Control and Prevention Zika Diagnosis: Challenges and Opportunities
Centers for Disease Control and Prevention Zika Diagnosis: Challenges and Opportunities Jorge L. Muñoz-Jordán, Ph.D. Chief, Surveillance and Research Laboratory Centers for Disease Control and Prevention
More informationSPECIALIZED FAMILY CARE Provider Training
SPECIALIZED FAMILY CARE Provider Training Category: Health Issue Title: Zika Virus Materials: Centers for Disease Control Fact Sheet on Zika Virus Goal: Specialized Family Care Provider to learn the risks,
More informationMosquito Threats in LA County West Nile virus & Zika
Mosquito Threats in LA County West Nile virus & Zika The District at a Glance An independent special district formed under authority of the CA State Health and Safety Code Formed in 1952 and governed by
More informationZIKA UPDATE NOVEMBER Ministry of Health, Barbados
ZIKA UPDATE NOVEMBER 2016 Ministry of Health, Barbados Zika Virus Disease Objectives By the end of this presentation you should be able: To recount the track of the current global Zika virus epidemic To
More informationRelevant Communicable Diseases in HCT/Ps
Relevant Communicable Diseases in HCT/Ps Phyllis I. Warkentin, MD Professor of Pathology and Pediatrics University of Nebraska Medical Center FACT Chief Medical Officer Relevant Communicable Diseases in
More informationFollowing the bite of a mosquito infected with CHIKV, most individuals will
3. CLINICAL 3A. Clinical Presentation of Acute Disease Following the bite of a mosquito infected with CHIKV, most individuals will present with symptomatic disease after an incubation period of 3-7 days
More informationZika Virus. Public Information Update/phone script. Date: March 28, 2016 Time: 11:00 a.m.
Zika Virus Public Information Update/phone script Date: March 28, 2016 Time: 11:00 a.m. ** Highlighted text indicates new, revised or updated information Note to operators: When people call asking questions
More informationZIKA VIRUS: INFORMATION FOR CLINICIANS
CDC S Response to Zika ZIKA VIRUS: INFORMATION FOR CLINICIANS Updated July 27, 2017 These slides provide clinicians with information about Zika virus epidemiology Diagnoses and testing Case reporting Zika
More informationAs suggested by one fellow student, please consider the CDC's "Final Rules for Control of Communicable Diseases: Interstate and Foreign
As suggested by one fellow student, please consider the CDC's "Final Rules for Control of Communicable Diseases: Interstate and Foreign http://www.cdc.gov/quarantine/ aboutlawsregulationsquarantineisolatio
More informationZika: Updates and Lessons Learned for Primary Care Clinicians
Zika: Updates and Lessons Learned for Primary Care Clinicians Kirsten Salmeen, MD Assistant Professor UCSF Obstetrics, Gynecology & Reproductive Sciences Maternal-Fetal Medicine I have no financial disclosures.
More informationCHIKUNGUNYA VIRUS INFECTION. Cesar Ponce S. Medical Microbiologist and Parasitologist. Epidemiologist ADC Medical Microbiology Department Director
CHIKUNGUNYA VIRUS INFECTION Cesar Ponce S. Medical Microbiologist and Parasitologist. Epidemiologist ADC Medical Microbiology Department Director Curacao, Aug. 2014 TOPICS: Definition History Epidemiology
More informationNorth Carolina Department of Health and Human Services Division of Public Health
North Carolina Department of Health and Human Services Division of Public Health Pat McCrory Governor February 8, 2016 (replaces version dated January 28, 2016) Richard O. Brajer Secretary Daniel Staley
More informationWhat s Hot in Pediatric Infectious Diseases Soren Gantt UBC Peds ID
What s Hot in Pediatric Infectious Diseases 2015-16 Soren Gantt UBC Peds ID ZIKA VIRUS!!! What is ZIKV? ZIKV is a flavivirus, related to dengue, yellow fever, West Nile and Japanese encephalitis Discovered
More informationZika Preparedness: Lessons for the U.S. Public Health System
Zika Preparedness: Lessons for the U.S. Public Health System Jeffrey Duchin, MD Health Officer, Public Health - Seattle & King County Professor in Medicine, Division of Infectious Diseases Adjunct Professor,
More informationZika Virus. It may be devastating, But we might just get one step ahead of it. Learning in Retirement Winter 2017 Daniel Burnside. photo: Newsweek.
Zika Virus It may be devastating, But we might just get one step ahead of it Learning in Retirement Winter 2017 Daniel Burnside photo: Newsweek.com INTRODUCTION TO VIRUSES STRUCTURE GENOME LIFE CYCLE
More informationWaiting in the Wings: Emergence, Impact and Control of Mosquito-Borne Viruses
International Center for Enterprise Preparedness (InterCEP) Waiting in the Wings: Emergence, Impact and Control of Mosquito-Borne Viruses Web Forum On April 14, 2016, Kathryn A. Hanley, Professor in the
More informationZIKA VIRUS TESTING GUIDANCE, UPDATED 7/20/2016
Section 1: Which patients should be offered testing? SUMMARY OF CATEGORIES OF PATIENTS WHO SHOULD BE TESTED FOR ZIKA 1) Pregnant women who traveled to a Zika-affected area (see link to current list in
More informationCenters for Disease Control and Prevention Zika Virus in Pregnancy What Midwives Need To Know
Centers for Disease Control and Prevention Zika Virus in Pregnancy What Midwives Need To Know Margaret A. Lampe, RN, MPH Pregnancy and Birth Defects Surveillance Team Zika Virus Emergency Response U.S.
More information